Page last updated: 2024-08-25

bendamustine hydrochloride and melphalan

bendamustine hydrochloride has been researched along with melphalan in 27 studies

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.70)18.2507
2000's2 (7.41)29.6817
2010's17 (62.96)24.3611
2020's7 (25.93)2.80

Authors

AuthorsStudies
Doll, K; Harstrick, A; Hoffmann, B; Seeber, S; Strumberg, D1
Niederwieser, D; Pönisch, W1
Assmann, M; Bittrich, A; Dachselt, K; Freund, M; Friedrich, T; Grobe, N; Harksel, B; Helbig, W; Herold, M; Merkle, K; Mitrou, PS; Niederwieser, D; Pasold, R; Pönisch, W; Richter, P; Schirmer, V; Schulze, A; Schulze, M; Stelzer, E; Subert, R; Wilhelm, G1
Gust, R; Scheffler, H; Scutaru, AM; Wenzel, M; Wolber, G1
Gust, R; Scutaru, AM; Wenzel, M1
Caballero, MD; Capria, S; Cuberli, F; Falcioni, S; Ferrara, F; Galieni, P; Gaudio, F; Gherlinzoni, F; Giardini, C; Gobbi, M; Isidori, A; Malerba, L; Meloni, G; Ocio, EM; Rocchi, M; Santoro, A; Sarina, B; Specchia, G; Stefani, PM; Visani, G1
Ciavarella, S; Cives, M; Dammacco, F; De Matteo, M; Rizzo, FM; Silvestris, F1
Coleman, M; Gergis, U; Greenberg, J; Mark, TM; Mayer, S; Niesvizky, R; Pearse, R; Reid, W; Shore, T; Van Besien, K1
Amiot, M; Descamps, G; Le Gouill, S; Lemieux-Blanchard, E; Maïga, S; Moreau, P; Pellat-Deceunynck, C; Surget, S1
Borchmann, P; Engert, A; Monsef, I; Rancea, M; Skoetz, N; Will, A1
Argnani, L; Maglie, R; Pellegrini, C; Pileri, S; Zinzani, PL1
Nakaseko, C1
Caballero, MD; Capria, S; Ferrara, F; Galieni, P; Gaudio, F; Gherlinzoni, F; Gobbi, M; Gonella, R; Isidori, A; Loscocco, F; Malerba, L; Meloni, G; Ocio, EM; Rocchi, M; Santoro, A; Specchia, G; Stefani, PM; Visani, G1
Burckhardt, G; Hagos, Y; Hundertmark, P; Marada, VV; Shnitsar, V; Wulf, G1
Console, G; Gentile, M; Martino, M; Messina, G; Molica, S; Morabito, F; Recchia, AG; Tripepi, G; Vincelli, ID1
Hogan, JJ; Weiss, BM1
Alenxandrova, K; Arfi-Rouche, J; Bourhis, JH; Castilla-Llorente, C; Danu, A; Ghez, D; Khalife-Saleh, N; Koscielny, S; Lapierre, V; Lazarovici, J; Legoupil, C; Michot, JM; Pilorge, S; Ribrag, V; Saleh, K1
Fornecker, LM; Guffroy, A; Korganow, AS; Martin, M; Meyer, A1
Boehm, A; Keil, F; Koller, E; Menschel, E; Moestl, M; Noesslinger, T; Panny, M; Simanek, R1
Christos, PJ; Coleman, M; Gergis, U; Gomez-Arteaga, A; Greenberg, JD; Guarneri, D; Hsu, J; Mark, TM; Mayer, SA; Niesvizky, R; Pearse, RN; Phillips, AA; Rossi, A; Shore, TB; van Besien, K1
Abraham, J; Borel, C; Bouabdallah, K; Bouabdallah, R; Casasnovas, RO; Chantepie, S; Damaj, G; Delapierre, B; Delette, C; Durot, E; Fornecker, LM; Garciaz, S; Gastinne, T; Gressin, R; Gyan, E; Houot, R; Hueso, T; Ibrahim, A; Le Gouill, S; Lemal, R; Malak, S; Morello, R; Peyrade, F; Tchernonog, E; Tessoulin, B; Tournilhac, O1
Cartron, G; Casasnovas, O; Dalban, C; Ghesquières, H; Hernandez, C; Jardin, F; Le Bras, F; Le Gouill, S; Metzger, S; Nicolas-Virelizier, E; Pérol, D; Vizoso, S1
Boudreault, JS; Desjardins, A; Feng, X; Le-Nguyen, V; Rioux, JP; Turgeon-Mallette, L; Veilleux, A; Vo, C1
Bouabdallah, K; Casasnovas, RO; Costes-Tertrais, D; Damaj, G; Dartigeas, C; Delette, C; Fogarty, P; Fornecker, LM; Garciaz, S; Gastinne, T; Gressin, R; Houot, R; Hueso, T; Le Gouill, S; Malak, S; Oberic, L; Ribrag, V; Tchernonog, E; Thieblemont, C1
An, LC; Chen, LM; Chu, XX; Feng, XY; Li, KM; Liu, XQ; Liu, YH; Ma, JJ; Sui, JR; Wang, JY; Wei, RX; Xu, JQ1
Bashey, A; Brown, S; Holland, HK; Jackson, KC; Morris, LE; Shegda, N; Solh, M; Solomon, SR; Zhang, X1
Ahmad, I; Bambace, N; Bernard, L; Boisjoly, JA; Bouchard, P; Bourguignon, A; Chagnon, M; Cohen, S; Delisle, JS; Fleury, I; Kiss, T; Lachance, S; Mollica, L; Roy, DC; Roy, J; Sauvageau, G; Veilleux, O; Zehr, J1

Reviews

3 review(s) available for bendamustine hydrochloride and melphalan

ArticleYear
[Treatment of transplant-eligible symptomatic multiple myeloma].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Autografts; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Combined Modality Therapy; Consolidation Chemotherapy; Cyclophosphamide; Dexamethasone; Drug Discovery; Hematopoietic Stem Cell Transplantation; Humans; Induction Chemotherapy; Lenalidomide; Maintenance Chemotherapy; Melphalan; Multiple Myeloma; Neoplasm, Residual; Nitrogen Mustard Compounds; Pyrazines; Remission Induction; Thalidomide; Transplantation Conditioning

2014
Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies of Renal Significance.
    Clinical journal of the American Society of Nephrology : CJASN, 2016, 09-07, Volume: 11, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Bortezomib; Cyclophosphamide; Dexamethasone; Humans; Immunoglobulins; Immunosuppressive Agents; Kidney Diseases; Lenalidomide; Melphalan; Oligopeptides; Paraproteinemias; Pentostatin; Rituximab; Thalidomide; Vidarabine

2016
[Sinusoidal obstruction syndrome after BeAM conditioning regiment for autologous stem cell transplantation: Imputability of bendamustine? Report of two cases and literature review].
    La Revue de medecine interne, 2018, Volume: 39, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Melphalan; Middle Aged; Transplantation Conditioning; Transplantation, Autologous

2018

Trials

9 trial(s) available for bendamustine hydrochloride and melphalan

ArticleYear
Bendamustine in the treatment of multiple myeloma: results and future perspectives.
    Seminars in oncology, 2002, Volume: 29, Issue:4 Suppl 13

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Cyclophosphamide; Female; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Nitrogen Mustard Compounds; Prednisolone; Prednisone; Prospective Studies; Remission Induction; Survival Rate

2002
Treatment of bendamustine and prednisone in patients with newly diagnosed multiple myeloma results in superior complete response rate, prolonged time to treatment failure and improved quality of life compared to treatment with melphalan and prednisone--a
    Journal of cancer research and clinical oncology, 2006, Volume: 132, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Disease-Free Survival; Female; Germany, East; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Nitrogen Mustard Compounds; Prednisone; Quality of Life; Remission Induction; Survival Analysis; Time Factors; Treatment Failure

2006
BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients.
    Blood, 2011, Sep-22, Volume: 118, Issue:12

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Cytarabine; Drug Resistance, Neoplasm; Etoposide; Female; Follow-Up Studies; Graft Survival; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Nitrogen Mustard Compounds; Recurrence; Remission Induction; Salvage Therapy; Transplantation Conditioning; Transplantation, Autologous

2011
A phase 1 study of bendamustine and melphalan conditioning for autologous stem cell transplantation in multiple myeloma.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2013, Volume: 19, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Combined Modality Therapy; Dose-Response Relationship, Drug; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Nitrogen Mustard Compounds; Transplantation Conditioning; Transplantation, Autologous

2013
Bendamustine, etoposide, cytarabine, melphalan, and autologous stem cell rescue produce a 72% 3-year PFS in resistant lymphoma.
    Blood, 2014, Nov-06, Volume: 124, Issue:19

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Combined Modality Therapy; Cytarabine; Drug Resistance, Neoplasm; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Non-Hodgkin; Melphalan; Nitrogen Mustard Compounds; Transplantation, Autologous

2014
A phase II, single-arm, prospective study of bendamustine plus melphalan conditioning for second autologous stem cell transplantation in de novo multiple myeloma patients through a tandem transplant strategy.
    Bone marrow transplantation, 2016, Volume: 51, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Diarrhea; Female; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Male; Melphalan; Middle Aged; Mucositis; Multiple Myeloma; Transplantation Conditioning; Treatment Outcome; Vomiting

2016
High-dose bendamustine and melphalan conditioning for autologous stem cell transplantation for patients with multiple myeloma.
    Bone marrow transplantation, 2019, Volume: 54, Issue:12

    Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Female; Humans; Male; Melphalan; Middle Aged; Multiple Myeloma; Transplantation, Autologous; Young Adult

2019
BeEAM (bendamustine, etoposide, cytarabine, melphalan) prior to autologous stem cell transplant for chemosensitive relapses in patients with follicular lymphoma: a prospective multicentre phase II study in Lymphoma Study Association centres
    British journal of haematology, 2021, Volume: 192, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Cytarabine; Etoposide; Humans; Lymphoma, Follicular; Melphalan; Prospective Studies; Stem Cell Transplantation; Transplantation, Autologous

2021
High-Dose Bendamustine, Etoposide, Cytarabine, and Melphalan (BeEAM) Conditioning Before Autologous Transplantation for Patients With Multiple Myeloma.
    Transplantation and cellular therapy, 2022, Volume: 28, Issue:8

    Topics: Bendamustine Hydrochloride; Cytarabine; Drug Therapy, Combination; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Melphalan; Multiple Myeloma; Neoplasm Recurrence, Local; Transplantation, Autologous

2022

Other Studies

15 other study(ies) available for bendamustine hydrochloride and melphalan

ArticleYear
Bendamustine hydrochloride activity against doxorubicin-resistant human breast carcinoma cell lines.
    Anti-cancer drugs, 1996, Volume: 7, Issue:4

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Breast Neoplasms; Carmustine; Cisplatin; Cyclophosphamide; DNA Damage; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Melphalan; Nitrogen Mustard Compounds; Ovarian Neoplasms; Tumor Cells, Cultured

1996
Optimization of the N-lost drugs melphalan and bendamustine: synthesis and cytotoxicity of a new set of dendrimer-drug conjugates as tumor therapeutic agents.
    Bioconjugate chemistry, 2010, Oct-20, Volume: 21, Issue:10

    Topics: Antineoplastic Agents, Alkylating; Bendamustine Hydrochloride; Cell Line, Tumor; Dendrimers; Endocytosis; Humans; Inhibitory Concentration 50; Melphalan; Models, Molecular; Molecular Conformation; Nanoconjugates; Nitrogen Mustard Compounds; Particle Size; Permeability

2010
Bivalent bendamustine and melphalan derivatives as anticancer agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:5

    Topics: Antineoplastic Agents; Bendamustine Hydrochloride; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Melphalan; Molecular Structure; Nitrogen Mustard Compounds; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

2011
Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe.
    Cellular signalling, 2013, Volume: 25, Issue:5

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Aurora Kinase A; Aurora Kinases; Bendamustine Hydrochloride; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cyclin B1; Drug Resistance, Neoplasm; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Melphalan; Mitosis; Nitrogen Mustard Compounds; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins

2013
Bendamustine and melphalan kill myeloma cells similarly through reactive oxygen species production and activation of the p53 pathway and do not overcome resistance to each other.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:9

    Topics: Bendamustine Hydrochloride; Cell Death; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Humans; Melphalan; Multiple Myeloma; Nitrogen Mustard Compounds; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53

2014
Sixteenth biannual report of the Cochrane Haematological Malignancies Group: focus on Non-Hodgkin's lymphoma.
    Journal of the National Cancer Institute, 2014, Volume: 106, Issue:8

    Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Boronic Acids; Bortezomib; Carmustine; Cyclophosphamide; Cytarabine; Doxorubicin; Drug Administration Schedule; Etoposide; Hematologic Neoplasms; Humans; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Melphalan; Nitriles; Nitrogen Mustard Compounds; Prednisone; Primary Myelofibrosis; Pyrazines; Pyrazoles; Pyrimidines; Quality of Life; Randomized Controlled Trials as Topic; Rituximab; Vincristine

2014
Impressive response to pegylated liposomal doxorubicin after allogeneic transplantation in a multi-relapsed Hodgkin's lymphoma.
    Hematological oncology, 2016, Volume: 34, Issue:1

    Topics: Allografts; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Brentuximab Vedotin; Carmustine; Combined Modality Therapy; Cytarabine; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Immunoconjugates; Lenalidomide; Liposomes; Male; Melphalan; Polyethylene Glycols; Recurrence; Remission Induction; Salvage Therapy; Thalidomide; Transplantation, Autologous; Young Adult

2016
Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.
    American journal of physiology. Renal physiology, 2015, Feb-15, Volume: 308, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Bendamustine Hydrochloride; Cell Proliferation; Chlorambucil; Dose-Response Relationship, Drug; Estrone; HEK293 Cells; Humans; Jurkat Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, T-Cell; Melphalan; Nitrogen Mustard Compounds; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Transfection; Tumor Cells, Cultured

2015
A retrospective, matched paired analysis comparing bendamustine containing BeEAM versus BEAM conditioning regimen: results from a single center experience.
    Leukemia & lymphoma, 2018, Volume: 59, Issue:11

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Case-Control Studies; Cytarabine; Diarrhea; Disease-Free Survival; Drug Resistance, Neoplasm; Etoposide; Female; Hodgkin Disease; Humans; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Retrospective Studies; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Autologous; Young Adult

2018
High-dose Bendamustine-EAM followed by autologous stem cell rescue results in long-term remission rates in lymphoma patients, without renal toxicity.
    European journal of haematology, 2018, Volume: 101, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Combined Modality Therapy; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Male; Melphalan; Middle Aged; Survival Analysis; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome; Young Adult

2018
Bendamustine-EAM versus BEAM regimen in patients with mantle cell lymphoma undergoing autologous stem cell transplantation in the frontline setting: a multicenter retrospective study from Lymphoma Study Association (LYSA) centers.
    Bone marrow transplantation, 2020, Volume: 55, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Cytarabine; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Mantle-Cell; Melphalan; Prospective Studies; Retrospective Studies; Transplantation, Autologous

2020
Bendamustine-induced nephrogenic diabetes insipidus - A case report.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2022, Volume: 28, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Cytarabine; Diabetes Insipidus, Nephrogenic; Diabetes Mellitus; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Melphalan; Transplantation, Autologous

2022
Bendamustine-EAM versus R-BEAM after high-dose cytarabine-based induction in newly diagnosed patients with mantle cell lymphoma, a LYSA retrospective study.
    Bone marrow transplantation, 2022, Volume: 57, Issue:4

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Cytarabine; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma, Mantle-Cell; Melphalan; Retrospective Studies; Transplantation, Autologous

2022
[Safety and the short-term efficacy of bendamustine in the conditioning regimen for autologous stem cell transplantation in patients with lymphoma].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2022, Jan-14, Volume: 43, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Melphalan; Transplantation Conditioning; Transplantation, Autologous

2022
Impact of Implementing a Bendamustine-Based Conditioning Regimen on Outcomes of Autologous Stem Cell Transplantation in Lymphoma while Novel Cellular Therapies Emerge.
    Transplantation and cellular therapy, 2023, Volume: 29, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Bendamustine Hydrochloride; Carmustine; Cytarabine; Hematopoietic Stem Cell Transplantation; Humans; Lymphoma; Melphalan; Retrospective Studies; Transplantation, Autologous

2023