bemethyl and pumitepa

Complex research of the genetic activity of a new 2-mercaptobenzimidazole derivative bemythyl has shown that the drug failed to induce recessive, age-related lethal mutations in drosophila, dominant lethal mutations in germ mammalian cells and chromosomal damage in murine bone marrow cells and human peripheral blood cell cultures. The experiments on mice have demonstrated that therapeutic bemythyl doses caused a two-fold decrease in the level of aberrant cells induced by alkylating agents--fotrin and fopurin.

Topics: Animals; Aziridines; Benzimidazoles; Drosophila melanogaster; Humans; Mice; Mice, Inbred C57BL; Mutagenicity Tests; Mutation; Purines