bemethyl and 3-(2-2-2-trimethylhydrazine)propionate

For development of a pharmaceutical composition improving physical performance, effects of various drugs and their combinations on forced swimming test performance were studied on laboratory rats. Maximum increase in animal performance was produced by a 3-component composition asparcam+mildronate+metaprote in proportion of 5.0, 10.7, and 14.3 mg/kg, respectively. No changes in blood serum biochemistry and morphological composition of the peripheral blood were detected after single intragastric administration of the composition.

Topics: Adenosine Triphosphate; Animals; Antioxidants; Aspartic Acid; Athletic Performance; Benzimidazoles; Central Nervous System Stimulants; Drug Combinations; Drug Evaluation, Preclinical; Drug Synergism; Ecdysterone; Energy Metabolism; Methylhydrazines; Performance-Enhancing Substances; Phenytoin; Physical Endurance; Proteins; Rats; Swimming; Weight-Bearing

The method of the study of medical agent influence and biological active substances on duration of small laboratory animals swimming has been worked out excluding the air. For this purpose the animals were placed into altitude chamber, filled with water by 1/3 (one-third) of its volume being in antiorthostatic position on dipping into water. It has been established that at the altitude of 4000 (four thousand) meters high the rat swimming duration became shorter in comparison with their work under normal pressure in 2.5-4 times. Bemitil stimulating work in hypobaric hypoxia depresses it sharply. Bemitil stimulating influence on the rat efficiency did not appear with rising. Antioxidant substance ionol increased efficiency in normal conditions and in hypoxia AKS-85 adaptogenic compound increased swimming in the height duration to a greater degree, mildronat substance for efficiency restoration produced actoprotective influence.

Topics: Amphetamine; Animals; Antioxidants; Atmosphere Exposure Chambers; Atmospheric Pressure; Benzimidazoles; Butylated Hydroxytoluene; Cardiovascular Agents; Hypoxia; Methylhydrazines; Mice; Physical Endurance; Posture; Swimming