bekanamycin has been researched along with phosphoric-acid* in 1 studies
1 other study(ies) available for bekanamycin and phosphoric-acid
| Article | Year |
|---|---|
Chiral phosphoric acid-catalyzed desymmetrizative glycosylation of 2-deoxystreptamine and its application to aminoglycoside synthesis.
This work describes chiral phosphoric acid (CPA)-catalyzed desymmetrizative glycosylation of meso-diol derived from 2-deoxystreptamine. The chirality of CPA dictates the outcome of the glycosylation reactions, and the use of enantiomeric CPAs results in either C4-glycosylated (67 : 33 d.r.) or C6-glycosylated (86 : 14 d.r.) 2-deoxystreptamines. These glycosylated products can be converted to aminoglycosides, and the application of this strategy to the synthesis of protected iso-neamine and iso-kanamycin B with inverted connection at the C4 and C6 positions is described. Topics: Aminoglycosides; Catalysis; Framycetin; Glycosylation; Hexosamines; Kanamycin; Phosphoric Acids; Stereoisomerism | 2017 |