Page last updated: 2024-09-04

bdp 12 and piperidines

bdp 12 has been researched along with piperidines in 53 studies

Compound Research Comparison

Studies (bdp 12)	Trials (bdp 12)	Recent Studies (post-2010) (bdp 12)	Studies (piperidines)	Trials (piperidines)	Recent Studies (post-2010) (piperidines)
62	7	14	40,235	5,221	14,545

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (24.53)	18.2507
2000's	29 (54.72)	29.6817
2010's	9 (16.98)	24.3611
2020's	2 (3.77)	2.80

Authors

Authors	Studies
Larson, J; LeDuc, B; Lieu, T; Lynch, G; Ngo, H; Petchpradub, V; Rogers, GA	1
Ambros-Ingerson, J; Granger, R; Kessler, M; Lynch, G; Rogers, G; Schehr, RS	1
Arai, A; Kessler, M; Lynch, G; Rogers, G	1
Fricker, J	1
Ambros-Ingerson, J; Davis, CM; Granger, R; Kessler, M; Lynch, G; Schehr, R	1
LeDoux, JE; Rogan, MT; Stäubli, UV	1
Ambros-Ingerson, J; Davis, M; Granger, R; Ingvar, M; Kessler, M; Lynch, G; Rogers, GA; Schehr, RS	1
Vanover, KE	1
Arai, A; Davis, CM; Granger, R; Lynch, G; Moskovitz, B; Nguyen, MA; Tran, BB	1
Deadwyler, SA; Hampson, RE; Lynch, G; Rogers, G	2
Arai, A; Lynch, G	1
Arai, A; Herbst, TA; Johnson, SA; Knapp, R; Lutz, D; Luu, NT; Lynch, G; Rogers, GA	1
Blanchet, PJ; Chase, TN; Konitsiotis, S; Lamers, E; Verhagen, L	1
Black, MD; Hanak, SE; Schilp, DE; Sorensen, SM; Wettstein, JG; Wotanis, J	1
Bódi, I; Gueritaud, J; Kapus, G; Pataki, A; Székely, JI; Tarnawa, I	1
Bleakman, D; Gates, MR; Grabell, J; Gupta, A; Ho, K; Jarvie, KR; Miu, P; Ogden, A; Ornstein, PL; Peters, D; Radhakrishnan, V; Zarrinmayeh, H; Zimmerman, DM	1
Bond, A; Huff, K; Lodge, D; Vandergriff, J	1
Baumbarger, PJ; Muhlhauser, M; Nisenbaum, ES; Yang, CR; Zhai, J	1
Berman, I; Goff, DC; Herz, L; Johnson, SA; Leahy, L; Leon, AC; Lynch, G; Posever, T	1
Boxall, AR; Nagarajan, N; Quast, C; Rosenmund, C; Shahid, M	1
Cecil, A; Crites, G; Goldenberg, R; Knapp, RJ; Malatynska, E; Miller, C; Shuck, C; Watkins, J	1
Danysz, W	2
Egan, MF; Goldberg, TE; Knable, MB; Marenco, S; McClure, RK; Weinberger, DR; Winterer, G	1
Arai, AC; Kessler, M; Lynch, G; Rogers, G; Xia, YF	1
Bahr, BA; Munirathinam, S; Rogers, G	1
Baumbarger, P; Bleakman, D; Gates, M; Hicks, CA; Lodge, D; Murray, TK; Nisenbaum, ES; O'Neill, MJ; Ogden, AM; Robinson, CS; Siuda, E; Skolnick, P; Vandergriff, JL; Ward, MA; Whalley, K; Zimmerman, DM	1
Ballew, N	1
Arai, AC; Suzuki, E; Xia, YF	1
Ferguson, SM; Robinson, TE	1
Tiihonen, J; Tuominen, HJ; Wahlbeck, K	1
Arai, AC; Kessler, M; Xia, YF	1
Black, MD	1
Lynch, G	1
Didriksen, M; Kreilgaard, M; Olsen, CK	1
Berry-Kravis, E; Block, SS; Cogswell, J; Cook, E; Decle, P; Guter, S; Hagerman, R; Jardini, T; Johnson, SA; Krause, SE; Lara, R; Leurgans, S; Maino, D; Potanos, K; Salt, J; Weinberg, D; Wuu, J	1
Freudenreich, O; Goff, DC; Green, MF; Johnson, SA; Lamberti, JS; Leon, AC; Manschreck, T; Miller, AL; Patel, J	1
Barnes, CA; Burke, SN; Maurer, AP; Navratilova, Z; Yang, Z	1
Bahr, BA; Kanju, PM; Parameshwaran, K; Shonesy, BC; Sims, C; Suppiramaniam, V	1
Broberg, BV; Dias, R; Glenthøj, BY; Larsen, DB; Olsen, CK	1
Ballesteros, J; Rueda, JR; Tejada, MI	1
Damgaard, T; Grayson, B; Hansen, SL; Larsen, DB; Neill, JC; Plath, N	1
Begemann, MJ; Leucht, S; Sommer, IE; Temmerman, A	1
Frydenvang, K; Gajhede, M; Harpsøe, K; Kastrup, JS; Krintel, C; Peters, D; Pickering, DS; Zachariassen, LG	1
Le, AM; Lee, M; Su, C; Wang, J; Zou, A	1
Barker, GR; Benn, A; Robinson, ES; Roloff, EV; Stuart, SA; Teschemacher, AG; Warburton, EC	1
Abe, M; Abe, T; Amano, K; Itohara, S; Mazaki, E; Miyamoto, H; Sakimura, K; Shimohata, A; Suzuki, T; Tatsukawa, T; Yamakawa, K	1
Johnson, S; Lippa, AS; Purcell, R; Radin, DP	1
Hattori, S; Itohara, S; Mazaki, E; Miyakawa, T; Miyamoto, H; Montal, M; Ogiwara, I; Raveau, M; Tatsukawa, T; Yamakawa, K	1
Amano, K; Hensch, TK; Itohara, S; Kobayashi, K; Mazaki, E; Miyamoto, H; Oba-Asaka, A; Ogiwara, I; Raveau, M; Sakimura, K; Shimohata, A; Suzuki, T; Tatsukawa, T; Yamagata, T; Yamakawa, K	1
Chen, X; Lan, X; Liu, H; Shen, H; Wang, X; Wu, X; Yao, H; Yu, H; Zhang, D; Zhang, G	1
Blumenstock, S; Dudanova, I	1

Reviews

7 review(s) available for bdp 12 and piperidines

Article	Year
Positive modulators of AMPA receptors as a potential treatment for schizophrenia. Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:7 Topics: Animals; Clinical Trials as Topic; Dioxoles; Drug Industry; Excitatory Amino Acid Agonists; Humans; Piperidines; Receptors, AMPA; Schizophrenia	2002
CX-516 Cortex pharmaceuticals. Current opinion in investigational drugs (London, England : 2000), 2002, Volume: 3, Issue:7 Topics: Animals; Clinical Trials as Topic; Dioxoles; Drug Industry; Humans; Mental Disorders; Piperidines	2002
Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis. Schizophrenia research, 2005, Jan-01, Volume: 72, Issue:2-3 Topics: Clozapine; Cycloserine; Dioxoles; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Agents; Glycine; Humans; Hydro-Lyases; Molindone; Piperidines; Schizophrenia	2005
Therapeutic potential of positive AMPA modulators and their relationship to AMPA receptor subunits. A review of preclinical data. Psychopharmacology, 2005, Volume: 179, Issue:1 Topics: Alzheimer Disease; Animals; Benzothiadiazines; Cognition; Dioxoles; Humans; Long-Term Potentiation; Memory; Neuroprotective Agents; Piperidines; Protein Subunits; Receptors, AMPA; Schizophrenia	2005
Glutamate-based therapeutic approaches: ampakines. Current opinion in pharmacology, 2006, Volume: 6, Issue:1 Topics: Animals; Brain; Cognition Disorders; Dioxoles; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Humans; Memory; Mental Disorders; Nerve Growth Factors; Oxazines; Piperidines; Protein Conformation; Receptors, AMPA	2006
Systematic review of pharmacological treatments in fragile X syndrome. BMC neurology, 2009, Oct-13, Volume: 9 Topics: Acetylcarnitine; Dioxoles; Folic Acid; Fragile X Syndrome; Humans; Methylphenidate; Piperidines; Treatment Outcome	2009
Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review. Schizophrenia bulletin, 2012, Volume: 38, Issue:5 Topics: Antipsychotic Agents; Brief Psychiatric Rating Scale; Citalopram; Clozapine; Dioxoles; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fructose; Humans; Lamotrigine; Piperidines; Psychiatric Status Rating Scales; Psychotropic Drugs; Randomized Controlled Trials as Topic; Schizophrenia; Schizophrenic Psychology; Sulpiride; Topiramate; Treatment Outcome; Triazines	2012

Trials

6 trial(s) available for bdp 12 and piperidines

Article	Year
Psychological effects of a drug that facilitates brain AMPA receptors. International clinical psychopharmacology, 1996, Volume: 11, Issue:1 Topics: Adult; Affect; Blood Pressure; Dioxoles; Double-Blind Method; Humans; Male; Memory, Short-Term; Piperidines; Psychotropic Drugs; Receptors, AMPA	1996
Evidence that a positive modulator of AMPA-type glutamate receptors improves delayed recall in aged humans. Experimental neurology, 1997, Volume: 145, Issue:1 Topics: Aged; Aging; Blood Pressure; Dioxoles; Heart Rate; Humans; Male; Mental Recall; Nootropic Agents; Piperidines; Psychometrics; Receptors, AMPA; Time Factors	1997
A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia. Journal of clinical psychopharmacology, 2001, Volume: 21, Issue:5 Topics: Adult; Antipsychotic Agents; Attention; Clozapine; Cognition; Dioxoles; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Memory; Middle Aged; Pilot Projects; Piperidines; Psychological Tests; Schizophrenia	2001
Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series. Schizophrenia research, 2002, Oct-01, Volume: 57, Issue:2-3 Topics: Adult; Antipsychotic Agents; Dioxoles; Double-Blind Method; Female; Humans; Male; Middle Aged; Piperidines; Psychotic Disorders; Schizophrenia	2002
Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial. Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:5 Topics: Adolescent; Adult; Autistic Disorder; Child Behavior Disorders; Cognition Disorders; Dioxoles; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Female; Fragile X Syndrome; Humans; Long-Term Potentiation; Male; Neuronal Plasticity; Neuropsychological Tests; Personality Assessment; Piperidines; Receptors, AMPA; Synaptic Transmission; Treatment Outcome	2006
A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008, Volume: 33, Issue:3 Topics: Adult; Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Dioxoles; Double-Blind Method; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Olanzapine; Pilot Projects; Piperidines; Psychiatric Status Rating Scales; Psychomotor Performance; Risperidone; Sample Size; Schizophrenia; Schizophrenic Psychology	2008

Other Studies

40 other study(ies) available for bdp 12 and piperidines

Article	Year
Facilitation of olfactory learning by a modulator of AMPA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:12 Topics: Animals; Cues; Dioxoles; Discrimination, Psychological; Learning; Motor Activity; Odorants; Piperidines; Postural Balance; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Smell	1995
Effects of a memory-enhancing drug on DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor currents and synaptic transmission in hippocampus. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 278, Issue:2 Topics: Animals; Dioxoles; Dose-Response Relationship, Drug; Hippocampus; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission	1996
From mechanisms to drugs in Alzheimer's disease. Lancet (London, England), 1997, Feb-15, Volume: 349, Issue:9050 Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Humans; Indans; Memory, Short-Term; Piperidines; Rats; Tacrine	1997
AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Aug-01, Volume: 17, Issue:15 Topics: Animals; Conditioning, Psychological; Dioxoles; Dose-Response Relationship, Drug; Fear; Learning; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA	1997
Enhancement by an ampakine of memory encoding in humans. Experimental neurology, 1997, Volume: 146, Issue:2 Topics: Adult; Association Learning; Cues; Dioxoles; Humans; Male; Maze Learning; Memory; Mental Recall; Odorants; Pattern Recognition, Visual; Piperidines; Receptors, AMPA; Space Perception; Visual Perception	1997
Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion. European journal of pharmacology, 1997, Aug-06, Volume: 332, Issue:2 Topics: Amphetamine; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Dioxoles; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; Locomotion; Male; Mice; Piperidines; Receptors, AMPA	1997
A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors. Psychopharmacology, 1997, Volume: 133, Issue:2 Topics: Animals; Dioxoles; Male; Maze Learning; Motor Activity; Piperidines; Pyrrolidines; Rats; Receptors, AMPA	1997
Facilitative effects of the ampakine CX516 on short-term memory in rats: enhancement of delayed-nonmatch-to-sample performance. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Apr-01, Volume: 18, Issue:7 Topics: Animals; Conditioning, Psychological; Dioxoles; Dose-Response Relationship, Drug; Hippocampus; Male; Memory, Short-Term; Piperidines; Rats; Rats, Inbred Strains; Spatial Behavior; Time Factors	1998
Facilitative effects of the ampakine CX516 on short-term memory in rats: correlations with hippocampal neuronal activity. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Apr-01, Volume: 18, Issue:7 Topics: Action Potentials; Animals; Behavior, Animal; Conditioning, Psychological; Dioxoles; Electrophysiology; Hippocampus; Male; Memory, Short-Term; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, AMPA	1998
The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization. Brain research, 1998, Jul-20, Volume: 799, Issue:2 Topics: Animals; Benzothiadiazines; Dioxoles; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses; Synaptic Transmission	1998
Synergistic interactions between ampakines and antipsychotic drugs. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1 Topics: Animals; Antipsychotic Agents; Catalepsy; Central Nervous System Stimulants; Dioxoles; Drug Synergism; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Haloperidol; Male; Methamphetamine; Motor Activity; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA	1999
AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys. Neurology, 2000, Apr-25, Volume: 54, Issue:8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Benzodiazepines; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Female; Levodopa; Macaca fascicularis; Male; Motor Activity; Parkinson Disease, Secondary; Piperidines; Receptors, AMPA; Severity of Illness Index	2000
Effect of AMPA receptor modulators on hippocampal and cortical function. European journal of pharmacology, 2000, Apr-07, Volume: 394, Issue:1 Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dioxoles; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Male; Piperidines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, AMPA	2000
Differential modulation of the GYKI 53784-induced inhibition of AMPA currents by various AMPA-positive modulators in cerebellar Purkinje cells. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cells, Cultured; Cerebellum; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Membrane Potentials; Piperidines; Purkinje Cells; Pyrrolidinones; Rats; Receptors, AMPA	2000
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro. Neuropharmacology, 2001, Volume: 40, Issue:8 Topics: Allosteric Regulation; Antihypertensive Agents; Benzothiadiazines; Calcium; Cell Line; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Electrophysiology; Excitatory Amino Acid Agonists; Humans; Piperidines; Receptors, AMPA; Receptors, Glutamate; Recombinant Proteins; Sulfonamides; Thiophenes	2001
Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo. Neuropharmacology, 2001, Volume: 40, Issue:8 Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Agonists; Female; Hippocampus; Injections, Intravenous; Male; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Spinal Cord; Stereotaxic Techniques; Sulfonamides; Thiophenes	2001
Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1 Topics: Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Piperidines; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sulfonamides	2001
Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology, 2001, Volume: 41, Issue:6 Topics: Allosteric Regulation; Benzothiadiazines; Cell Line; Dioxoles; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Patch-Clamp Techniques; Piperidines; Receptors, AMPA; Synaptic Transmission	2001
Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model. European journal of pharmacology, 2002, Apr-05, Volume: 440, Issue:1 Topics: Animals; Antidepressive Agents; Competitive Behavior; Desipramine; Diazepam; Dioxoles; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Maze Learning; Models, Animal; Nootropic Agents; Piperidines; Piracetam; Pyrrolidinones; Rats; Rats, Sprague-Dawley	2002
Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3 Topics: Allosteric Regulation; Animals; Benzamides; Binding Sites; Dioxoles; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission	2002
Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptors elicits neuroprotection after trimethyltin exposure in hippocampus. Toxicology and applied pharmacology, 2002, Dec-01, Volume: 185, Issue:2 Topics: Animals; Calpain; Dioxoles; Excitatory Amino Acid Antagonists; Female; Hippocampus; In Vitro Techniques; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Spectrin; Trimethyltin Compounds	2002
LY503430, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor potentiator with functional, neuroprotective and neurotrophic effects in rodent models of Parkinson's disease. The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:2 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amides; Animals; Biphenyl Compounds; Cells, Cultured; Corpus Striatum; Dioxoles; Disease Models, Animal; Excitatory Amino Acid Agonists; GAP-43 Protein; Hippocampus; Humans; Male; Neurons; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Substantia Nigra	2003
Cortex Pharmaceuticals, Inc. Maintaining brain function goes a long way. Chemistry & biology, 2003, Volume: 10, Issue:11 Topics: Animals; Brain; Cognition Disorders; Dioxoles; Drug Industry; Humans; Piperidines; Receptors, AMPA; Schizophrenia	2003
Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus. Neuroscience, 2004, Volume: 123, Issue:4 Topics: Animals; Animals, Newborn; Benzothiadiazines; Cell Line; Central Nervous System Stimulants; Dioxoles; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Embryo, Mammalian; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kidney; Long-Term Potentiation; Neuronal Plasticity; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synapses; Time Factors; Transfection	2004
Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascade. Journal of neurochemistry, 2004, Volume: 91, Issue:2 Topics: Afferent Pathways; Amphetamine; Animals; Cell Count; Dioxoles; Enzyme Inhibitors; Gene Expression Regulation; Genes, Immediate-Early; Globus Pallidus; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Motor Activity; Neostriatum; Neurons; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger	2004
Positive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor modulators have different impact on synaptic transmission in the thalamus and hippocampus. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 313, Issue:1 Topics: Animals; Benzothiadiazines; Dioxoles; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission; Thalamus	2005
Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats. Pharmacology, biochemistry, and behavior, 2006, Volume: 84, Issue:2 Topics: Animals; Antipsychotic Agents; Avoidance Learning; Benzodiazepines; Clozapine; Conditioning, Psychological; Dioxoles; Drug Synergism; Isoxazoles; Male; Olanzapine; Paliperidone Palmitate; Piperidines; Pyrimidines; Rats; Rats, Wistar; Receptors, AMPA; Risperidone; Serine; Stereoisomerism	2006
Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats. Behavioral neuroscience, 2008, Volume: 122, Issue:3 Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Psychological; Dioxoles; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Male; Memantine; Memory Disorders; Movement; Neuronal Plasticity; Piperidines; Rats; Rats, Inbred F344; Receptors, Glutamate; Space Perception; Theta Rhythm	2008
Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Experimental neurology, 2008, Volume: 214, Issue:1 Topics: Animals; Dioxoles; Excitatory Postsynaptic Potentials; Hippocampus; Lysosomes; Miniature Postsynaptic Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Signal Processing, Computer-Assisted; Synaptic Transmission	2008
Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology, 2009, Volume: 206, Issue:4 Topics: Animals; Antipsychotic Agents; Attention; Dioxoles; Disease Models, Animal; Dose-Response Relationship, Drug; Imidazoles; Indoles; Male; Phencyclidine; Piperidines; Rats; Schizophrenia	2009
Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors reverses sub-chronic PCP-induced deficits in the novel object recognition task in rats. Behavioural brain research, 2010, Feb-11, Volume: 207, Issue:1 Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Dioxoles; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Hallucinogens; Memory Disorders; Motor Activity; Phencyclidine; Piperidines; Rats; Receptors, AMPA; Recognition, Psychology; Video Recording; Visual Perception	2010
Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain. Acta crystallographica. Section D, Biological crystallography, 2013, Volume: 69, Issue:Pt 9 Topics: Allosteric Regulation; Animals; Crystallography, X-Ray; Dioxoles; Ligands; Macromolecular Substances; Mutation; Oxazines; Piperidines; Protein Binding; Protein Interaction Mapping; Protein Structure, Tertiary; Rats; Receptors, AMPA	2013
AMPAkines have novel analgesic properties in rat models of persistent neuropathic and inflammatory pain. Anesthesiology, 2014, Volume: 121, Issue:5 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Behavior, Animal; Dioxoles; Inflammation; Male; Motor Activity; Neuralgia; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Swimming	2014
Optogenetic Stimulation of Prefrontal Glutamatergic Neurons Enhances Recognition Memory. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 05-04, Volume: 36, Issue:18 Topics: Animals; Dioxoles; Excitatory Postsynaptic Potentials; Glutamates; Male; Memory; Memory, Short-Term; Neurons; Optogenetics; Piperidines; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Psychomotor Performance; Pyridones; Rats; Receptors, Metabotropic Glutamate; Recognition, Psychology	2016
Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency. Human molecular genetics, 2017, 12-15, Volume: 26, Issue:24 Topics: Aggression; Animals; Brain; Dioxoles; Excitatory Postsynaptic Potentials; Haploinsufficiency; Intellectual Disability; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Munc18 Proteins; Neurodevelopmental Disorders; Neurons; Piperidines; Synapses; Synaptic Transmission	2017
Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 105 Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Dioxoles; Male; Nerve Growth Factors; Piperidines; Piriform Cortex; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger	2018
Molecular autism, 2019, Volume: 10 Topics: Animals; Anxiety; Autism Spectrum Disorder; Dioxoles; Gamma Rhythm; Haploinsufficiency; Male; Membrane Transport Modulators; Memory; Mice; Mice, Inbred C57BL; NAV1.2 Voltage-Gated Sodium Channel; Phenotype; Piperidines; Prefrontal Cortex; Psychomotor Agitation; Social Behavior	2019
Impaired cortico-striatal excitatory transmission triggers epilepsy. Nature communications, 2019, 04-23, Volume: 10, Issue:1 Topics: Action Potentials; Animals; Anticonvulsants; Corpus Striatum; Dioxoles; Electroencephalography; Epilepsy, Absence; Ethosuximide; Gene Expression Regulation; Haploinsufficiency; Interneurons; Mice; Mice, Knockout; Munc18 Proteins; NAV1.2 Voltage-Gated Sodium Channel; Neocortex; Neural Pathways; Piperidines; Receptors, AMPA; Seizures; Signal Transduction; Synaptic Transmission; Thalamus	2019
AMPAkine CX516 alleviated chronic ethanol exposure-induced neurodegeneration and depressive-like behavior in mice. Toxicology and applied pharmacology, 2022, 03-15, Volume: 439 Topics: Animals; Dioxoles; Ethanol; Hippocampus; Mice; Piperidines; Receptors, AMPA	2022
Balancing neuronal circuits. Science (New York, N.Y.), 2022, 09-23, Volume: 377, Issue:6613 Topics: Aging; Animals; Dioxoles; Huntington Disease; Mice; Mice, Transgenic; Nerve Net; Neurons; Piperidines; Synapses	2022