Page last updated: 2024-09-04

bcx 1812 and oseltamivir

bcx 1812 has been researched along with oseltamivir in 15 studies

Compound Research Comparison

Studies
(bcx 1812)
Trials
(bcx 1812)
Recent Studies (post-2010)
(bcx 1812)
Studies
(oseltamivir)
Trials
(oseltamivir)
Recent Studies (post-2010) (oseltamivir)
251123,3681862,014

Protein Interaction Comparison

ProteinTaxonomybcx 1812 (IC50)oseltamivir (IC50)
Neuraminidase Influenza A virus (A/Turkey/651242/2006(H5N1))0.1104
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))0.2616
Neuraminidase Influenza A virus (A/duck/Laos/25/2006(H5N1))2.0317
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))1.1344
NeuraminidaseInfluenza A virus (A/USSR/90/1977(H1N1))0.002
NeuraminidaseInfluenza B virus (B/Lee/1940)0.005
Acyl-CoA desaturase 1Mus musculus (house mouse)0.008
Neuraminidase Influenza A virus (A/chicken/Yogjakarta/BBVet-IX/2004(H5N1))0.0043
Neuraminidase Influenza A virus (A/Thailand/1(KAN-1)/2004(H5N1))0.0003
NeuraminidaseInfluenza A virus (A/Singapore/1/1957(H2N2))0.003
NeuraminidaseInfluenza A virus (A/Aichi/2/1968(H3N2))0.0016

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (26.67)29.6817
2010's8 (53.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Elliott, AJ; Hutchison, TL; Kotian, PL; Lin, TH; Montgomery, JA1
Chen, XG; Chen, YL; Hu, ZD; Liu, MC; Lü, WJ; Luan, F; Ma, WP; Zhang, XY1
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E1
Barr, IG; Holien, JK; Hurt, AC1
Demmler-Harrison, GJ; Deyde, VM; Gubareva, LV; Klimov, AI; Okomo-Adhiambo, M; Sheu, TG; Xu, X1
Chavas, LM; Dyason, JC; Fusi, P; Kato, R; Mann, MC; McKimm-Breschkin, J; Monti, E; Suzuki, N; Tettamanti, G; Thomson, RJ; Tringali, C; Venerando, B; von Itzstein, M; Wakatsuki, S1
Gubareva, LV; Klimov, AI; Mishin, VP; Nguyen, HT; Sheu, TG1
Barrett, S; McKimm-Breschkin, JL; Newman, J; Oakley, AJ; Peat, TS; Saito, T; Streltsov, VA; Tashiro, M; Waddington, L1
Boulanger, MJ; Brant, MG; Bromba, CM; Chan, T; Lunke, MD; Mason, JW; Petric, M; Wulff, JE1
Cheng, LP; Li, L; Pang, W; Wang, Z; Zhang, XH; Zhao, JL1
Cheng, TJ; Chiu, DC; Fang, JM; Huang, WI; Jan, JT; Li, TT; Tsai, KC; Tseng, YC; Wang, PC1
Cairo, CW; Guo, T; Hunter, CD; Richards, MR1
Bourguet, E; Figurska, S; Fra Czek, MM1
Aljohani, MA; Keil, JM; Rafn, GR; Sahebjam-Atabaki, R; Sun, XL; Turan, IM1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1

Reviews

2 review(s) available for bcx 1812 and oseltamivir

ArticleYear
Human Neuraminidases: Structures and Stereoselective Inhibitors.
    Journal of medicinal chemistry, 2022, 02-24, Volume: 65, Issue:4

    Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Models, Molecular; Neuraminidase; Stereoisomerism; Structure-Activity Relationship

2022
Sialidase Inhibitors with Different Mechanisms.
    Journal of medicinal chemistry, 2022, 10-27, Volume: 65, Issue:20

    Topics: Antiviral Agents; Biological Products; Enzyme Inhibitors; Humans; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Zanamivir

2022

Other Studies

13 other study(ies) available for bcx 1812 and oseltamivir

ArticleYear
Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.
    Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25

    Topics: Acids, Carbocyclic; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Cyclopentanes; Enzyme Inhibitors; Guanidines; Influenza A virus; Models, Molecular; Neuraminidase; Protein Binding; Stereoisomerism; Structure-Activity Relationship

2001
QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:3

    Topics: Enzyme Inhibitors; Linear Models; Models, Biological; Neuraminidase; Quantitative Structure-Activity Relationship

2008
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
    Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2

    Topics: Anti-Infective Agents; Antiviral Agents; Artificial Intelligence; Computer Simulation; Drug Evaluation, Preclinical; Molecular Structure; Quantitative Structure-Activity Relationship

2009
In vitro generation of neuraminidase inhibitor resistance in A(H5N1) influenza viruses.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:10

    Topics: Animals; Antiviral Agents; Cell Line; Dogs; Influenza A Virus, H5N1 Subtype; Mutagenesis, Site-Directed; Mutation; Neuraminidase; Orthomyxoviridae Infections; Reverse Transcriptase Polymerase Chain Reaction

2009
Detection of E119V and E119I mutations in influenza A (H3N2) viruses isolated from an immunocompromised patient: challenges in diagnosis of oseltamivir resistance.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:5

    Topics: Antiviral Agents; Cells, Cultured; Child, Preschool; Drug Resistance, Viral; Genetic Testing; Humans; Immunocompromised Host; Influenza A Virus, H3N2 Subtype; Influenza, Human; Male; Molecular Sequence Data; Neuraminidase; Oseltamivir; Point Mutation; Sequence Analysis, DNA

2010
Complexity in influenza virus targeted drug design: interaction with human sialidases.
    Journal of medicinal chemistry, 2010, Apr-08, Volume: 53, Issue:7

    Topics: Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Models, Molecular; Molecular Conformation; Neuraminidase; Orthomyxoviridae

2010
Assessment of pandemic and seasonal influenza A (H1N1) virus susceptibility to neuraminidase inhibitors in three enzyme activity inhibition assays.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Acids, Carbocyclic; Animals; Cell Line; Cyclopentanes; Dogs; Enzyme Assays; Enzyme Inhibitors; Guanidines; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Inhibitory Concentration 50; Neuraminidase; Oseltamivir; Zanamivir

2010
Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses.
    Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17

    Topics: Acids, Carbocyclic; Antiviral Agents; Crystallography, X-Ray; Cyclopentanes; Drug Resistance, Viral; Guanidines; Hydrogen Bonding; Influenza B virus; Models, Molecular; Molecular Structure; Mutation; Neuraminidase; Oseltamivir; Protein Binding; Zanamivir

2010
The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.
    Bioorganic & medicinal chemistry letters, 2011, Dec-01, Volume: 21, Issue:23

    Topics: Acids, Carbocyclic; Antiviral Agents; Crystallography, X-Ray; Cyclopentanes; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Guanidines; Humans; Influenza A virus; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Neuraminidase; Protein Binding; Recombinant Proteins; Zanamivir

2011
Design, synthesis and biological evaluation of novel oseltamivir derivatives as potent neuraminidase inhibitors.
    Bioorganic & medicinal chemistry letters, 2017, 12-15, Volume: 27, Issue:24

    Topics: Antiviral Agents; Binding Sites; Drug Design; Enzyme Inhibitors; Humans; Influenza A Virus, H5N1 Subtype; Influenza A Virus, H7N9 Subtype; Inhibitory Concentration 50; Molecular Docking Simulation; Neuraminidase; Oseltamivir; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship

2017
Peramivir conjugates as orally available agents against influenza H275Y mutant.
    European journal of medicinal chemistry, 2018, Feb-10, Volume: 145

    Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Cyclopentanes; Dogs; Dose-Response Relationship, Drug; Guanidines; HEK293 Cells; Humans; Influenza A virus; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Mutation; Rabbits; Structure-Activity Relationship

2018
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.
    Bioorganic & medicinal chemistry, 2018, 10-15, Volume: 26, Issue:19

    Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Neuraminidase; Sequence Alignment; Viral Proteins; Zanamivir

2018
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023