bcx 1812 has been researched along with 2-deoxy-2,3-dehydro-n-acetylneuraminic acid in 6 studies
| Studies (bcx 1812) | Trials (bcx 1812) | Recent Studies (post-2010) (bcx 1812) | Studies (2-deoxy-2,3-dehydro-n-acetylneuraminic acid) | Trials (2-deoxy-2,3-dehydro-n-acetylneuraminic acid) | Recent Studies (post-2010) (2-deoxy-2,3-dehydro-n-acetylneuraminic acid) |
|---|---|---|---|---|---|
| 25 | 1 | 12 | 149 | 0 | 44 |
| Protein | Taxonomy | bcx 1812 (IC50) | 2-deoxy-2,3-dehydro-n-acetylneuraminic acid (IC50) |
|---|---|---|---|
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | 0.753 | |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 9.3 | |
| Sialidase | Vibrio cholerae O1 biovar El Tor str. N16961 | 8.6 | |
| Sialidase A | Streptococcus pneumoniae | 7.4 | |
| Sialidase-4 | Homo sapiens (human) | 8.3 | |
| Sialidase-3 | Homo sapiens (human) | 6.6875 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ananth, SL; Babu, YS; Bantia, S; Chand, P; Dehghani, A; El-Kattan, Y; Elliott, AJ; Horn, LL; Hutchison, TL; Kotian, P; Laver, GW; Lin, TH; Montgomery, JA; Parker, CD | 1 |
| Chen, XG; Chen, YL; Hu, ZD; Liu, MC; Lü, WJ; Luan, F; Ma, WP; Zhang, XY | 1 |
| Chavas, LM; Dyason, JC; Fusi, P; Kato, R; Mann, MC; McKimm-Breschkin, J; Monti, E; Suzuki, N; Tettamanti, G; Thomson, RJ; Tringali, C; Venerando, B; von Itzstein, M; Wakatsuki, S | 1 |
| Cairo, CW; Guo, T; Hunter, CD; Richards, MR | 1 |
| Bourguet, E; Figurska, S; Fra Czek, MM | 1 |
| Aljohani, MA; Keil, JM; Rafn, GR; Sahebjam-Atabaki, R; Sun, XL; Turan, IM | 1 |
2 review(s) available for bcx 1812 and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
Human Neuraminidases: Structures and Stereoselective Inhibitors.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Models, Molecular; Neuraminidase; Stereoisomerism; Structure-Activity Relationship | 2022 |
Sialidase Inhibitors with Different Mechanisms.
Topics: Antiviral Agents; Biological Products; Enzyme Inhibitors; Humans; N-Acetylneuraminic Acid; Neuraminidase; Oseltamivir; Sialic Acids; Zanamivir | 2022 |
4 other study(ies) available for bcx 1812 and 2-deoxy-2,3-dehydro-n-acetylneuraminic acid
| Article | Year |
|---|---|
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Topics: Acids, Carbocyclic; Administration, Oral; Animals; Antiviral Agents; Catalytic Domain; Crystallography, X-Ray; Cyclopentanes; Drug Design; Enzyme Inhibitors; Guanidines; Influenza A virus; Influenza B virus; Mice; Models, Molecular; Neuraminidase; Orthomyxoviridae Infections; Protein Binding; Stereoisomerism; Structure-Activity Relationship | 2000 |
QSAR study of neuraminidase inhibitors based on heuristic method and radial basis function network.
Topics: Enzyme Inhibitors; Linear Models; Models, Biological; Neuraminidase; Quantitative Structure-Activity Relationship | 2008 |
Complexity in influenza virus targeted drug design: interaction with human sialidases.
Topics: Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H5N1 Subtype; Models, Molecular; Molecular Conformation; Neuraminidase; Orthomyxoviridae | 2010 |
Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.
Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Isoenzymes; Kinetics; Molecular Dynamics Simulation; Neuraminidase; Sequence Alignment; Viral Proteins; Zanamivir | 2018 |