bazedoxifene has been researched along with raloxifene in 7 studies
| Studies (bazedoxifene) | Trials (bazedoxifene) | Recent Studies (post-2010) (bazedoxifene) | Studies (raloxifene) | Trials (raloxifene) | Recent Studies (post-2010) (raloxifene) |
|---|---|---|---|---|---|
| 307 | 69 | 249 | 128 | 0 | 61 |
| Protein | Taxonomy | bazedoxifene (IC50) | raloxifene (IC50) |
|---|---|---|---|
| Phospholipase D2 | Homo sapiens (human) | 6.1333 | |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | 0.5 | |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | 2.08 | |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 1.178 | |
| Estrogen receptor | Homo sapiens (human) | 0.0416 | |
| Estrogen receptor | Rattus norvegicus (Norway rat) | 0.0032 | |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | 3.666 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.282 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 1.664 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 2 | |
| D(2) dopamine receptor | Homo sapiens (human) | 1.174 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 3.698 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.738 | |
| Substance-K receptor | Homo sapiens (human) | 3.989 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 3.864 | |
| Acetylcholinesterase | Homo sapiens (human) | 0.4 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.282 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.973 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 1.45 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 1.178 | |
| Adenosine receptor A2a | Homo sapiens (human) | 2.111 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 3.576 | |
| Mu-type opioid receptor | Homo sapiens (human) | 1.176 | |
| D(3) dopamine receptor | Homo sapiens (human) | 1.565 | |
| Delta-type opioid receptor | Homo sapiens (human) | 6.644 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 1.602 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.355 | |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | 0.008 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.869 | |
| Aldehyde oxidase | Homo sapiens (human) | 0.0055 | |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | 0.0003 | |
| Phospholipase D1 | Homo sapiens (human) | 4.9167 | |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | 0.5 | |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | 0.1584 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.3051 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 0.681 | |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | 1.1 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Abou-Gharbia, MA; Bender, RH; Collini, MD; Greenberger, LM; Harris, HA; Henderson, RA; Kharode, YP; Komm, BS; Lyttle, CR; Marzolf, JT; Miller, CP; Moran, RA; Tran, BD; Unwalla, RJ; Yardley, JP | 1 |
| Birzin, ET; Blizzard, TA; Chan, W; DaSilva, CA; Dininno, F; Hammond, ML; Hayes, EC; Morgan, JD; Mosley, RT; Pai, LY; Rohrer, SP; Yang, YT | 1 |
| Furukawa, T; Hosoya, K; Kadono, K; Moriguchi, H; Nakamori, F; Naritomi, Y; Teramura, T; Terashita, S; Tetsuka, K; Yamano, K | 1 |
| Jou, D; Kumari, V; Li, C; Li, H; Lin, J; Lin, L; Xiao, H | 1 |
| Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L | 1 |
| Chen, H; Dubrovyskyii, O; Dye, K; Gordon-Blake, J; Gutgesell, LM; He, D; Hollas, M; Huang, F; Lasek, AW; Lee, S; Li, Y; Lu, Y; Rosales, CI; Shen, Z; Thatcher, GRJ; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J | 1 |
| Anantpadma, M; Cheng, H; Cooper, L; Davey, RA; Dye, K; Li, Y; Medegan Fagla, B; Nowar, R; Rong, L; Schafer, A; Shen, Z; Thatcher, GRJ; Xiong, R | 1 |
7 other study(ies) available for bazedoxifene and raloxifene
| Article | Year |
|---|---|
Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.
Topics: Animals; Bone Density; Cell Line; Estradiol Congeners; Female; Indoles; Models, Molecular; Organ Size; Ovariectomy; Radioligand Assay; Rats; Structure-Activity Relationship; Transfection; Uterus | 2001 |
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Topics: Animals; Estrogen Receptor alpha; Ligands; Oxathiins; Rats; Selective Estrogen Receptor Modulators | 2005 |
Quantitative prediction of human intestinal glucuronidation effects on intestinal availability of UDP-glucuronosyltransferase substrates using in vitro data.
Topics: Administration, Oral; Biotransformation; Cell Membrane Permeability; Cytochrome P-450 Enzyme System; Glucuronides; Glucuronosyltransferase; Humans; Intestinal Absorption; Intestines; Isoenzymes; Kinetics; Metabolic Clearance Rate; Microsomes; Models, Biological; Pharmaceutical Preparations; Recombinant Proteins; Substrate Specificity | 2012 |
Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cytokine Receptor gp130; Drug Design; Drug Repositioning; Drug Screening Assays, Antitumor; Humans; Indoles; Interleukin-6; Ligands; Molecular Docking Simulation; Phosphorylation; Protein Interaction Domains and Motifs; Protein Multimerization; Raloxifene Hydrochloride; Signal Transduction; STAT3 Transcription Factor | 2014 |
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship | 2016 |
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.
Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors.
Topics: Antiviral Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; Filoviridae; Humans; Ligands; Membrane Fusion; Models, Biological; Receptors, Estrogen; Structure-Activity Relationship | 2020 |