bazedoxifene has been researched along with lasofoxifene in 21 studies
| Studies (bazedoxifene) | Trials (bazedoxifene) | Recent Studies (post-2010) (bazedoxifene) | Studies (lasofoxifene) | Trials (lasofoxifene) | Recent Studies (post-2010) (lasofoxifene) |
|---|---|---|---|---|---|
| 307 | 69 | 249 | 88 | 14 | 24 |
| Protein | Taxonomy | bazedoxifene (IC50) | lasofoxifene (IC50) |
|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | 0.0046 | |
| Estrogen receptor | Rattus norvegicus (Norway rat) | 0.0112 | |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | 0.0112 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.0077 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 15 (71.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Birzin, ET; Blizzard, TA; Chan, W; DaSilva, CA; Dininno, F; Hammond, ML; Hayes, EC; Morgan, JD; Mosley, RT; Pai, LY; Rohrer, SP; Yang, YT | 1 |
| Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L | 1 |
| Chaki, O | 1 |
| Ohta, H | 1 |
| Crabtree, JS; Harris, HA; Komm, BS; Peano, BJ; Winneker, RC | 1 |
| de Villiers, TJ | 1 |
| Lewiecki, EM | 1 |
| Bodine, PV; Chang, KC; Komm, BS; Nagpal, S; Wang, Y | 1 |
| Biserni, A; Caruso, D; Ciana, P; Horner, D; Komm, B; Maggi, A; Ramachandran, B; Rando, G | 1 |
| Silverman, SL | 1 |
| Schmidt, C | 1 |
| Archer, DF | 1 |
| Palacios, S | 1 |
| Chines, AA; Komm, BS | 1 |
| Hadji, P | 1 |
| Calaf Alsina, J; Coronado MartÃn, PJ | 1 |
| Pinkerton, JV; Stanczyk, FZ | 1 |
| Kumar, P; Song, ZH | 1 |
| Pinkerton, JV; Thomas, S | 1 |
| Andersson, A; Bernardi, AI; Carlsten, H; Islander, U; Nurkkala-Karlsson, M; Ohlsson, C; Stubelius, A | 1 |
| Austin-Muttitt, K; Chen, S; Lau, AJ; Mullins, JGL; Zhang, LH | 1 |
10 review(s) available for bazedoxifene and lasofoxifene
| Article | Year |
|---|---|
[Next generation selective estrogen receptor modulators].
Topics: Animals; Bone Density; Bone Density Conservation Agents; Cholesterol; Female; Humans; Indoles; Osteoporosis; Pyrrolidines; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Uterus | 2006 |
[Status of novel bone-targeting SERMs in development].
Topics: Animals; Bone and Bones; Bone Density; Clinical Trials as Topic; Drug Design; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Research; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2007 |
Clinical issues regarding cardiovascular disease and selective estrogen receptor modulators in postmenopausal women.
Topics: Cardiovascular Diseases; Female; Humans; Indoles; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Selective Estrogen Receptor Modulators; Stroke; Tamoxifen; Tetrahydronaphthalenes; Venous Thromboembolism | 2009 |
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health | 2009 |
New selective estrogen receptor modulators (SERMs) in development.
Topics: Bone Density Conservation Agents; Breast Neoplasms; Female; Humans; Indoles; Osteoporosis; Piperidines; Pyrrolidines; Risk Factors; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Thiophenes | 2010 |
An update on selective estrogen receptor modulators for the prevention and treatment of osteoporosis.
Topics: Bone Density Conservation Agents; Breast; Endometrium; Female; Fractures, Bone; Humans; Indoles; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2012 |
The evolution of selective estrogen receptor modulators in osteoporosis therapy.
Topics: Aged; Aged, 80 and over; Bone Density; Bone Density Conservation Agents; Breast Neoplasms; Endometrial Neoplasms; Female; Fractures, Bone; Hot Flashes; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Spinal Fractures; Tetrahydronaphthalenes | 2012 |
[Third generation selective estrogen receptor modulators: benefits beyond bone. II, endometrial action].
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation, Preclinical; Endometrial Neoplasms; Endometrium; Estradiol; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Menopause; Multicenter Studies as Topic; Organ Specificity; Osteoporosis, Postmenopausal; Piperidines; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Thromboembolism | 2013 |
Clinical effects of selective estrogen receptor modulators on vulvar and vaginal atrophy.
Topics: Atrophy; Estrogens; Estrogens, Conjugated (USP); Female; Humans; Indoles; Pelvic Organ Prolapse; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Treatment Outcome; Vagina; Vaginal Diseases; Vulva; Vulvar Diseases | 2014 |
Use of SERMs for treatment in postmenopausal women.
Topics: Breast Neoplasms; Clinical Trials as Topic; Dyspareunia; Estrogens, Conjugated (USP); Female; Hot Flashes; Humans; Indoles; Osteoporosis; Osteoporosis, Postmenopausal; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Toremifene | 2014 |
11 other study(ies) available for bazedoxifene and lasofoxifene
| Article | Year |
|---|---|
Estrogen receptor ligands. Part 14: application of novel antagonist side chains to existing platforms.
Topics: Animals; Estrogen Receptor alpha; Ligands; Oxathiins; Rats; Selective Estrogen Receptor Modulators | 2005 |
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts.
Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship | 2016 |
Effects of various selective estrogen receptor modulators with or without conjugated estrogens on mouse mammary gland.
Topics: Amphiregulin; Animals; Dose-Response Relationship, Drug; EGF Family of Proteins; Estrogens, Conjugated (USP); Female; Glycoproteins; Indoles; Intercellular Signaling Peptides and Proteins; Mammary Glands, Animal; Mice; Mice, Inbred C57BL; Organ Size; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Uterus | 2009 |
Gene expression profiling studies of three SERMs and their conjugated estrogen combinations in human breast cancer cells: insights into the unique antagonistic effects of bazedoxifene on conjugated estrogens.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cluster Analysis; Down-Regulation; Estradiol; Estrogen Antagonists; Estrogens, Conjugated (USP); Female; Gene Expression; Gene Expression Profiling; Humans; Indoles; Oligonucleotide Array Sequence Analysis; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Signal Transduction; Tetrahydronaphthalenes; Up-Regulation | 2010 |
An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals.
Topics: Animals; Blotting, Western; Estradiol; Estrogens, Conjugated (USP); Female; Indoles; Mice; Mice, Inbred C57BL; Ovariectomy; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Transcription, Genetic | 2010 |
Third-generation SERMs may face uphill battle.
Topics: Anticarcinogenic Agents; Bone Density Conservation Agents; Breast Neoplasms; Clinical Trials as Topic; Drug Approval; Drug Industry; Estradiol; Evidence-Based Medicine; Female; Fractures, Bone; Humans; Indoles; Osteoporosis, Postmenopausal; Patents as Topic; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Risk; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; United States; United States Food and Drug Administration | 2010 |
The gynecologic effects of lasofoxifene, an estrogen agonist/antagonist, in postmenopausal women.
Topics: Breast Neoplasms; Estrogen Antagonists; Estrogens; Female; Female Urogenital Diseases; Humans; Indoles; Osteoporosis, Postmenopausal; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes | 2011 |
Selective estrogen receptor modulators: the future in menopausal treatment.
Topics: Female; Forecasting; Humans; Indoles; Menopause; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes | 2011 |
CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene.
Topics: Benzoxazines; Cyclic AMP; Dronabinol; Drug Inverse Agonism; HEK293 Cells; Humans; Indoles; Morpholines; Naphthalenes; Pyrrolidines; Receptor, Cannabinoid, CB2; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes | 2014 |
Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis.
Topics: Animals; Area Under Curve; Arthritis, Experimental; Biomarkers; Collagen; Disease Models, Animal; Female; Flow Cytometry; Humans; Indoles; Interleukin-6; Mice; Mice, Inbred DBA; Osteoarthritis; Osteoporosis, Postmenopausal; Ovariectomy; Pyrrolidines; Random Allocation; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes; Treatment Outcome | 2016 |
In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues.
Topics: Aldehyde Oxidase; Binding Sites; Female; Humans; Indoles; Liver; Male; Molecular Docking Simulation; Protein Binding; Pyrrolidines; Selective Estrogen Receptor Modulators; Tetrahydronaphthalenes | 2019 |