Page last updated: 2024-09-04

bazedoxifene and fulvestrant

bazedoxifene has been researched along with fulvestrant in 6 studies

Compound Research Comparison

Studies (bazedoxifene)	Trials (bazedoxifene)	Recent Studies (post-2010) (bazedoxifene)	Studies (fulvestrant)	Trials (fulvestrant)	Recent Studies (post-2010) (fulvestrant)
307	69	249	2,712	207	1,196

Protein Interaction Comparison

Protein	Taxonomy	fulvestrant (IC50)
Estrogen receptor	Homo sapiens (human)	0.0061
Estrogen receptor	Rattus norvegicus (Norway rat)	0.0059
Progesterone receptor	Homo sapiens (human)	0.0002
Steroid hormone receptor ERR1	Homo sapiens (human)	0.002
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	0.006
Estrogen receptor beta	Homo sapiens (human)	0.0104
Bile acid receptor	Homo sapiens (human)	0.79
NAD-dependent protein deacylase sirtuin-5, mitochondrial	Homo sapiens (human)	2.6

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (83.33)	24.3611
2020's	1 (16.67)	2.80

Authors

Authors	Studies
Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L	1
Chen, H; Dubrovyskyii, O; Dye, K; Gordon-Blake, J; Gutgesell, LM; He, D; Hollas, M; Huang, F; Lasek, AW; Lee, S; Li, Y; Lu, Y; Rosales, CI; Shen, Z; Thatcher, GRJ; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J	1
Han, SJ; Liu, S; Smith, CL	1
Komm, BS; Pickar, JH	1
Brown, M; Buchwalter, G; Carlson, KE; Chandarlapaty, S; Dharmarajan, V; Fanning, SW; Fowler, CE; Greene, GL; Griffin, PR; Han, R; Hosfield, DJ; Houtman, R; Jeselsohn, R; Karimi, M; Katzenellenbogen, JA; Lainé, M; Martin, TA; Mayne, CG; Nettles, KW; Nowak, J; Nwachukwu, JC; Shen, Y; Tajkhorshid, E; Toy, W	1
Jeselsohn, RM	1

Reviews

1 review(s) available for bazedoxifene and fulvestrant

Article	Year
Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast. Post reproductive health, 2015, Volume: 21, Issue:3 Topics: Animals; Breast; Breast Neoplasms; Drug Therapy, Combination; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Conjugated (USP); Female; Fulvestrant; Humans; Indoles; Osteoporosis; Postmenopause; Protective Factors; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene	2015

Article

Year

Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast.

Post reproductive health, 2015, Volume: 21, Issue:3

Topics: Animals; Breast; Breast Neoplasms; Drug Therapy, Combination; Estradiol; Estrogen Antagonists; Estrogens; Estrogens, Conjugated (USP); Female; Fulvestrant; Humans; Indoles; Osteoporosis; Postmenopause; Protective Factors; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Toremifene

2015

Other Studies

5 other study(ies) available for bazedoxifene and fulvestrant

Article	Year
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship	2016
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer. Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24 Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Cooperative activation of gene expression by agonists and antagonists mediated by estrogen receptor heteroligand dimer complexes. Molecular pharmacology, 2013, Volume: 83, Issue:5 Topics: Cell Line, Tumor; DNA; Estradiol; Estrogen Antagonists; Estrogens; Fulvestrant; Gene Expression; HeLa Cells; Hep G2 Cells; Humans; Indoles; Ligands; Mutation; Promoter Regions, Genetic; Protein Multimerization; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Transcription, Genetic; Transcriptional Activation	2013
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. eLife, 2018, 11-29, Volume: 7 Topics: Breast Neoplasms; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Indoles; Ligands; MCF-7 Cells; Mutant Proteins; Mutation; Piperazines; Protein Binding; Protein Domains; Protein Structure, Secondary; Pyridines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Tamoxifen	2018
The evolving use of SERDs in estrogen receptor-positive, HER2-negative metastatic breast cancer. Clinical advances in hematology & oncology : H&O, 2021, Volume: 19, Issue:7 Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Indoles; Neoplasm Metastasis; Receptor, ErbB-2; Receptors, Estrogen; Selective Estrogen Receptor Modulators	2021