Page last updated: 2024-09-04

bazedoxifene and afimoxifene

bazedoxifene has been researched along with afimoxifene in 2 studies

Compound Research Comparison

Studies (bazedoxifene)	Trials (bazedoxifene)	Recent Studies (post-2010) (bazedoxifene)	Studies (afimoxifene)	Trials (afimoxifene)	Recent Studies (post-2010) (afimoxifene)
307	69	249	1,255	10	325

Protein Interaction Comparison

Protein	Taxonomy	afimoxifene (IC50)
Phospholipase D2	Homo sapiens (human)	6.5
Estrogen receptor	Homo sapiens (human)	0.0105
Estrogen-related receptor gamma	Homo sapiens (human)	0.0084
Phospholipase D1	Homo sapiens (human)	6.5
Estrogen receptor beta	Homo sapiens (human)	0.0102

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chen, H; Dubrovyskyii, O; Dye, K; Gordon-Blake, J; Gutgesell, LM; He, D; Hollas, M; Huang, F; Lasek, AW; Lee, S; Li, Y; Lu, Y; Rosales, CI; Shen, Z; Thatcher, GRJ; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J	1
Bolton, JL; Chandrasena, RE; Choi, J; Hemachandra, LP; Michalsen, BT; Patel, H; Piyankarage, SC; Scism, RA; Siklos, MI; Thatcher, GR; Thayer, EN; Wang, S; Wang, Y; Xiong, R	1

Other Studies

2 other study(ies) available for bazedoxifene and afimoxifene

Article	Year
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer. Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24 Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:5 Topics: Cell Transformation, Neoplastic; Cells, Cultured; Cytoprotection; Estradiol; Humans; Inactivation, Metabolic; Indoles; Mammary Glands, Human; MCF-7 Cells; Oxidants; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Up-Regulation	2014

Article

Year

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer.

Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24

Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2019

SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.

Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:5

Topics: Cell Transformation, Neoplastic; Cells, Cultured; Cytoprotection; Estradiol; Humans; Inactivation, Metabolic; Indoles; Mammary Glands, Human; MCF-7 Cells; Oxidants; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Up-Regulation

2014