Compounds > bay x 1005
Page last updated: 2024-09-03

bay x 1005 and leukotriene b4

bay x 1005 has been researched along with leukotriene b4 in 16 studies

Compound Research Comparison

Studies
(bay x 1005)		Trials
(bay x 1005)		Recent Studies (post-2010)
(bay x 1005)		Studies
(leukotriene b4)		Trials
(leukotriene b4)		Recent Studies (post-2010) (leukotriene b4)
58685,886232717

Protein Interaction Comparison

ProteinTaxonomybay x 1005 (IC50)leukotriene b4 (IC50)
Leukotriene B4 receptor 1Homo sapiens (human)0.0019

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (68.75)18.2507
2000's5 (31.25)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dahlén, SE; Jonsson, EW1
Fruchtmann, R; Goossens, J; Hatzelmann, A; Mohrs, KH; Müller-Peddinghaus, R; Raddatz, S1
Fruchtmann, R; Hatzelmann, A; Mohrs, KH; Müller-Peddinghaus, R; Raddatz, S2
Brink, C; Gardiner, PJ; Gascard, JP; Gorenne, I; Labat, C; Mohrs, KH; Müller-Peddinghaus, R; Norel, X; Taylor, WA1
Fruchtmann, R; Fugmann, B; Hatzelmann, A; Horstmann, H; Junge, B; Mohrs, KH; Müller-Peddinghaus, R; Raddatz, S1
Medvedeff, ED; Nickerson-Nutter, CL1
Amann, R; Lanz, I; Peskar, BA; Schuligoi, R1
Andrews, M; Cunningham, FM; Landoni, MF; Lees, P1
Fischer, AR; Israel, E; Jungerwirth, S; Loper, M; Rosenberg, MA; Roth, M1
Bell, RL; Bhatia, P; Bouska, JB; Brooks, CD; Carter, GW; Harris, RR; Hulkower, KI; Kalosa, T; Malo, PE; Moore, J1
Di Battista, JA; He, W; Laufer, S; Martel-Pelletier, J; Pelletier, JP1
Gompertz, S; Stockley, RA1
Lajeunesse, D; Laufer, S; Martel-Pelletier, J; Massicotte, F; Paredes, Y; Pelletier, JP1
Cirino, G; Distrutti, E; Fiorucci, S; Laufor, SA; Mencarelli, A; Morelli, A; Wallace, JL1
Adalsteinsdottir, AE; Agnarsson, U; Andersen, K; Andresdottir, M; Arnar, DO; Bjornsdottir, H; Einarsson, A; Gottskalksson, G; Gudbjartsson, D; Gudmundsdottir, H; Gudmundsson, K; Gulcher, J; Gurney, M; Hakonarson, H; Hardarson, T; Helgadottir, A; Jonsson, A; Kong, A; Kristinsson, A; Kristjansson, K; Manolescu, A; Sigurdsson, A; Stefansson, K; Thorgeirsson, G; Thorvaldsson, S; Topol, EJ; Zink, F1

Trials

3 trial(s) available for bay x 1005 and leukotriene b4

ArticleYear
Effect of a novel 5-lipoxygenase activating protein inhibitor, BAYx 1005, on asthma induced by cold dry air.
    Thorax, 1997, Volume: 52, Issue:12

    Topics: Adolescent; Adult; Analysis of Variance; Asthma; Bronchial Provocation Tests; Calcimycin; Cold Temperature; Cross-Over Studies; Double-Blind Method; Humans; Ionophores; Leukotriene B4; Lipoxygenase Inhibitors; Middle Aged; Quinolines

1997
A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD.
    Chest, 2002, Volume: 122, Issue:1

    Topics: Aged; Bronchitis, Chronic; Double-Blind Method; Female; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Male; Pulmonary Diffusing Capacity; Pulmonary Disease, Chronic Obstructive; Quinolines

2002
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial.
    JAMA, 2005, May-11, Volume: 293, Issue:18

    Topics: 5-Lipoxygenase-Activating Proteins; Aged; Biomarkers; Carrier Proteins; Coronary Artery Disease; Cross-Over Studies; Epoxide Hydrolases; Female; Humans; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Middle Aged; Myocardial Infarction; Peroxidase; Polymorphism, Single Nucleotide; Prospective Studies; Quinolines; Risk Factors

2005

Other Studies

13 other study(ies) available for bay x 1005 and leukotriene b4

ArticleYear
Leukotrienes and other mediators of the Schultz-Dale reaction in guinea-pig lung parenchyma.
    Advances in prostaglandin, thromboxane, and leukotriene research, 1995, Volume: 23

    Topics: Animals; Guinea Pigs; Inflammation; Leukotriene B4; Leukotrienes; Lung; Male; Metiamide; Ovalbumin; Pyrilamine; Quinolines

1995
Inversely-correlated inhibition of human 5-lipoxygenase activity by BAY X1005 and other quinoline derivatives in intact cells and a cell-free system--implications for the function of 5-lipoxygenase activating protein.
    Biochemical pharmacology, 1994, Jun-15, Volume: 47, Issue:12

    Topics: Binding Sites; Cell Membrane; Cell-Free System; Enzyme Activation; Fatty Acids; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Quinolines; Solubility; Structure-Activity Relationship

1994
Ca2+ ionophore A23187-stimulated secretion of azurophil granules in human polymorphonuclear leukocytes is largely mediated by endogenously formed leukotriene B4.
    Biochemical pharmacology, 1994, Jul-05, Volume: 48, Issue:1

    Topics: Calcimycin; Cell Degranulation; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinolines

1994
(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Bronchi; Bronchoconstriction; Female; Humans; Immunoglobulin E; In Vitro Techniques; Indoles; Indomethacin; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines

1994
In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis.
    Agents and actions, 1993, Volume: 38, Issue:3-4

    Topics: Animals; Arachidonic Acid; Calcimycin; Cells, Cultured; Humans; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Macrophages, Peritoneal; Methemoglobin; Mice; Mice, Inbred BALB C; Neutrophils; Quinolines; Rats; Rats, Wistar; Reactive Oxygen Species; Stereoisomerism; Xanthine Oxidase; Zymosan

1993
Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds.
    Biochemical pharmacology, 1993, Jan-07, Volume: 45, Issue:1

    Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cell-Free System; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Kinetics; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Quinolines; Rats; Structure-Activity Relationship; Subcellular Fractions

1993
The effect of leukotriene synthesis inhibitors in models of acute and chronic inflammation.
    Arthritis and rheumatism, 1996, Volume: 39, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chronic Disease; Disease Models, Animal; Drug Combinations; Exudates and Transudates; Female; Hydroxyurea; Inflammation; Leukotriene B4; Lipoxygenase; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Naproxen; Prostaglandin-Endoperoxide Synthases; Quinolines; Time Factors; Zymosan

1996
Effect of a 5-lipoxygenase inhibitor on nerve growth factor-induced thermal hyperalgesia in the rat.
    European journal of pharmacology, 1996, Jun-13, Volume: 306, Issue:1-3

    Topics: Animals; Hot Temperature; Hyperalgesia; Leukotriene B4; Lipoxygenase Inhibitors; Male; Nerve Growth Factors; Pain Threshold; Quinolines; Rats; Rats, Sprague-Dawley

1996
Pharmacology of the 5-lipoxygenase inhibitors BAY Y 1015 and BAY X 1005 in the horse.
    Journal of veterinary pharmacology and therapeutics, 1997, Volume: 20, Issue:4

    Topics: Administration, Oral; Animals; Calcimycin; Carrageenan; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Exudates and Transudates; Female; Horses; Injections, Intravenous; Leukotriene B4; Leukotriene C4; Lipoxygenase Inhibitors; Male; Neutrophils; Quinolines

1997
Characterization of A-93178, an iminoxy-quinoline inhibitor of leukotriene biosynthesis.
    Advances in experimental medicine and biology, 1997, Volume: 433

    Topics: Animals; Calcimycin; Dogs; Humans; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Metabolic Clearance Rate; Molecular Structure; Neutrophils; Quinolines

1997
Synthesis of interleukin 1beta, tumor necrosis factor-alpha, and interstitial collagenase (MMP-1) is eicosanoid dependent in human osteoarthritis synovial membrane explants: interactions with antiinflammatory cytokines.
    The Journal of rheumatology, 2002, Volume: 29, Issue:3

    Topics: Aged; Cells, Cultured; Dinoprostone; Eicosanoids; Fibroblasts; Humans; Interleukin-1; Leukotriene B4; Lipoxygenase Inhibitors; Matrix Metalloproteinase 1; Middle Aged; Osteoarthritis; Quinolines; Synovial Membrane; Tumor Necrosis Factor-alpha

2002
Study of the role of leukotriene B()4 in abnormal function of human subchondral osteoarthritis osteoblasts: effects of cyclooxygenase and/or 5-lipoxygenase inhibition.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:7

    Topics: Acetates; Alkaline Phosphatase; Blotting, Western; Cyclooxygenase Inhibitors; Dinoprostone; Female; Humans; In Vitro Techniques; Leukotriene B4; Lipoxygenase Inhibitors; Male; Middle Aged; Nitrobenzenes; Osteoarthritis; Osteoblasts; Osteocalcin; Pyrroles; Quinolines; Sulfonamides

2002
Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin.
    British journal of pharmacology, 2003, Volume: 139, Issue:7

    Topics: Acetates; Acetylation; Adhesiveness; Arachidonate 5-Lipoxygenase; Aspirin; CD11a Antigen; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; E-Selectin; Eicosanoids; Endothelial Cells; Endothelium, Vascular; Fatty Alcohols; Glycols; Humans; Isoenzymes; Leukocytes; Leukotriene B4; Lipopolysaccharides; Lipoxins; Lipoxygenase; Membrane Proteins; Neutrophils; Prostaglandin-Endoperoxide Synthases; Prostaglandins E; Pyrans; Pyrroles; Quinolines; Quinolones; Umbilical Cord; Up-Regulation

2003