Page last updated: 2024-09-03

bay x 1005 and l 663536

bay x 1005 has been researched along with l 663536 in 8 studies

Compound Research Comparison

Studies
(bay x 1005)
Trials
(bay x 1005)
Recent Studies (post-2010)
(bay x 1005)
Studies
(l 663536)
Trials
(l 663536)
Recent Studies (post-2010) (l 663536)
58684854138

Protein Interaction Comparison

ProteinTaxonomybay x 1005 (IC50)l 663536 (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.023
Prostaglandin E synthaseHomo sapiens (human)2.2274
Prostaglandin G/H synthase 1Ovis aries (sheep)8
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)0.57
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)0.005
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.023
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)0.025
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.023
Prostaglandin G/H synthase 2Homo sapiens (human)2.4
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.023
Leukotriene C4 synthaseHomo sapiens (human)3
Macrophage-expressed gene 1 proteinHomo sapiens (human)2.2
GABA theta subunitRattus norvegicus (Norway rat)0.023
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.023
Prostaglandin E synthase 2Homo sapiens (human)1.6

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (87.50)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brooks, CD; Summers, JB1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Carpenter, TG; Cuthbert, NJ; Fitzgerald, MF; Francis, HP; Gardiner, PJ; Mohrs, K; Müller-Peddinghaus, R; Newton, BB; Patel, UP; Thompson, AM1
Dahlén, SE; Jonsson, EW1
Brink, C; Gardiner, PJ; Gascard, JP; Gorenne, I; Labat, C; Mohrs, KH; Müller-Peddinghaus, R; Norel, X; Taylor, WA1
Fruchtmann, R; Hatzelmann, A; Mohrs, KH; Müller-Peddinghaus, R; Raddatz, S1
Alaoui, HS; Brink, C; De Montpreville, V; Gascard, JP; Gorenne, I; Labat, C; Norel, X1
Folco, G; Henson, PM; Murphy, RC; Sala, A1

Reviews

1 review(s) available for bay x 1005 and l 663536

ArticleYear
Modulators of leukotriene biosynthesis and receptor activation.
    Journal of medicinal chemistry, 1996, Jul-05, Volume: 39, Issue:14

    Topics: 5-Lipoxygenase-Activating Proteins; Animals; Carrier Proteins; Forecasting; Humans; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Membrane Proteins; Molecular Structure; Receptors, Leukotriene

1996

Other Studies

7 other study(ies) available for bay x 1005 and l 663536

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Inhibition of antigen-induced contraction of guinea-pig airways by a leukotriene synthesis inhibitor, BAY x1005.
    European journal of pharmacology, 1994, Jun-02, Volume: 258, Issue:1-2

    Topics: 5-Lipoxygenase-Activating Proteins; Administration, Oral; Animals; Benzoquinones; Bronchoconstriction; Carrier Proteins; Guinea Pigs; Hydroxyurea; In Vitro Techniques; Indoles; Injections, Intravenous; Leukotriene Antagonists; Lipoxygenase Inhibitors; Male; Membrane Proteins; Ovalbumin; Pyrans; Quinolines; Quinolones; Trachea

1994
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Ovalbumin; Platelet Activating Factor; Quinolines; Triazoles

1994
(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Bronchi; Bronchoconstriction; Female; Humans; Immunoglobulin E; In Vitro Techniques; Indoles; Indomethacin; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines

1994
Mode of action of the new selective leukotriene synthesis inhibitor BAY X 1005 ((R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl acetic acid) and structurally related compounds.
    Biochemical pharmacology, 1993, Jan-07, Volume: 45, Issue:1

    Topics: Animals; Arachidonic Acid; Binding Sites; Binding, Competitive; Cell-Free System; Humans; Hydroxyeicosatetraenoic Acids; Indoles; Kinetics; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophils; Platelet Activating Factor; Quinolines; Rats; Structure-Activity Relationship; Subcellular Fractions

1993
Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma.
    Life sciences, 1996, Volume: 59, Issue:13

    Topics: Humans; Immunoglobulin E; Indoles; Indomethacin; Kinetics; Leukotriene Antagonists; Leukotrienes; Lung; Protein Synthesis Inhibitors; Quinolines

1996
Pharmacological modulation of human platelet leukotriene C4-synthase.
    Biochemical pharmacology, 1997, Mar-21, Volume: 53, Issue:6

    Topics: Blood Platelets; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Indoles; Lipoxygenase Inhibitors; Neutrophils; Quinolines

1997