Compounds > bay x 1005
Page last updated: 2024-09-03

bay x 1005 and indomethacin

bay x 1005 has been researched along with indomethacin in 6 studies

Compound Research Comparison

Studies
(bay x 1005)		Trials
(bay x 1005)		Recent Studies (post-2010)
(bay x 1005)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
586829,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomybay x 1005 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (83.33)18.2507
2000's1 (16.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dahlén, SE; Jonsson, EW1
Brink, C; Gardiner, PJ; Gascard, JP; Gorenne, I; Labat, C; Mohrs, KH; Müller-Peddinghaus, R; Norel, X; Taylor, WA1
Alaoui, HS; Brink, C; De Montpreville, V; Gascard, JP; Gorenne, I; Labat, C; Norel, X1
Amann, R; Donnerer, J; Peskar, BA; Schuligoi, R1
Burchardt, ER; Müller-Peddinghaus, R1
Bara, J; Brink, C; de Montpreville, VT; Gascard, JP; Roger, P1

Other Studies

6 other study(ies) available for bay x 1005 and indomethacin

ArticleYear
Interactions between leukotrienes and histamine in the anaphylactic contraction of guinea pig lung parenchyma.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:2

    Topics: Anaphylaxis; Animals; Azepines; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Indomethacin; Leukotriene Antagonists; Leukotrienes; Lung; Male; Muscle Contraction; Ovalbumin; Platelet Activating Factor; Quinolines; Triazoles

1994
(R)-2-[4-(quinolin-2-yl-methoxy)phenyl]-2-cyclopentyl] acetic acid (BAY x1005), a potent leukotriene synthesis inhibitor: effects on anti-IgE challenge in human airways.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:2

    Topics: Bronchi; Bronchoconstriction; Female; Humans; Immunoglobulin E; In Vitro Techniques; Indoles; Indomethacin; Leukotriene B4; Leukotriene E4; Lipoxygenase Inhibitors; Male; Quinolines

1994
Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma.
    Life sciences, 1996, Volume: 59, Issue:13

    Topics: Humans; Immunoglobulin E; Indoles; Indomethacin; Kinetics; Leukotriene Antagonists; Leukotrienes; Lung; Protein Synthesis Inhibitors; Quinolines

1996
Release of calcitonin gene-related peptide in cardiac anaphylaxis.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Anaphylaxis; Animals; Calcitonin Gene-Related Peptide; Cimetidine; Coronary Circulation; Cyclooxygenase Inhibitors; Guinea Pigs; Heart; Histamine H1 Antagonists; Histamine H2 Antagonists; In Vitro Techniques; Indomethacin; Leukotriene C4; Lipoxygenase Inhibitors; Myocardium; Ovalbumin; Pyrilamine; Quinolines; Thromboxane B2

1997
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
    Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug Therapy, Combination; Ear; Edema; Female; Histamine H1 Antagonists; Indomethacin; Inflammation; Lipoxygenase Inhibitors; Methysergide; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrilamine; Quinolines; Serotonin Antagonists

1997
MUC5AC mucin release from human airways in vitro: effects of indomethacin and Bay X1005.
    Mediators of inflammation, 2001, Volume: 10, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Cyclooxygenase Inhibitors; Humans; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Mucin 5AC; Mucins; Quinolines

2001