bay-k-8644 has been researched along with verapamil in 202 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 72 (35.64) | 18.7374 |
| 1990's | 95 (47.03) | 18.2507 |
| 2000's | 26 (12.87) | 29.6817 |
| 2010's | 7 (3.47) | 24.3611 |
| 2020's | 2 (0.99) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Cuddon, P; Fleming, A; Floto, RA; Goldsmith, P; Jahreiss, L; O'Kane, CJ; Pask, D; Rubinsztein, DC; Saiki, S; Sarkar, S; Siddiqi, FH; Ttofi, EK; Williams, A | 1 |
| Iakushkin, VV; Orekhov, AN | 1 |
| Hallaq, H; Leaf, A; Smith, TW | 1 |
| Harbon, S; Khac, LD; Mokhtari, A; Renner, M | 1 |
| Katayose, D; Ogata, M; Ohe, M; Takishima, T | 1 |
| De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR | 1 |
| Benedek, G; Horvàth, G; Szikszay, M | 1 |
| Brooks, M; Echt, DS; Schräder, R | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Abiko, Y; Ichihara, K; Nasa, Y; Yoshida, R | 1 |
| Collins, P; Jiang, C; Poole-Wilson, PA; Sarrel, PM | 1 |
| Bennett, MR; Kerr, R; Khurana, G | 1 |
| Finkel, MS; Oddis, CV; Romeo, RC; Salama, G | 1 |
| Kurtz, A; Scholz, H | 1 |
| Ferrari, R; Pasini, E; Poli, E; Raddino, R | 1 |
| Chang, JP; Jobin, RM | 1 |
| Raij, L; Shultz, PJ | 1 |
| Birkenhäger, JC; Buurman, CJ; Pols, HA; Schilte, JP; van Leeuwen, JP | 1 |
| Fox, R; Markham, A; Morgan, R | 1 |
| Marsh, JD; O'Neill, M; Sen, LY; Smith, TW | 1 |
| Naitoh, T; Sugimoto, T; Toyo-Oka, T | 1 |
| Baydoun, AR; Markham, A; Morgan, RM; Sweetman, AJ | 1 |
| Ballesta, JJ; Garcia, AG; Gutierrez, LM; Hidalgo, MJ; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Högestätt, ED; Skärby, TV | 1 |
| McNeill, JH; Yu, Z | 1 |
| Herchuelz, A; Lebrun, P; Plasman, PO | 1 |
| Ahrén, B; Ar'Rajab, A; Bengmark, S | 1 |
| Braver-Chernobul'skaia, BS; Gorchakova, NA; Lebed', OI; Shevchuk, VG; Zhirnov, VV; Zueva, NA | 1 |
| Tan, SY; Tepperman, BL; Whittle, BJ | 1 |
| Helwig, JJ; Judes, C; Musso, MJ; Nickols, GA | 1 |
| Brocklehurst, KW; Ceña, V; Pollard, HB; Rojas, E | 1 |
| Adamantidis, MM; Adnet, PJ; Cordonnier, C; Haudecoeur, G; Krivosic-Horber, RM; Reyford, H | 1 |
| Dutar, P; Lamour, Y; Potier, B; Rascol, O | 1 |
| Fusco, AC; Salafsky, B; Shibuya, T; Vanderkooi, G | 1 |
| Carignani, C; Marchetti, C; Robello, M | 1 |
| Baeyens, JM; Barrios, M | 2 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Koek, L; Melvin, JE; Zhang, GH | 1 |
| Ferrier, J; Kesthely, A; Lagan, E; Richter, C | 1 |
| Aitken, S; McCaig, DJ | 1 |
| Crevel, H; Marthan, R; Savineau, JP | 1 |
| Memo, M; Pizzi, M; Ribola, M; Spano, P; Valerio, A | 1 |
| Boll, W; Lux, HD | 1 |
| Coruzzi, G; Poli, E | 1 |
| Creba, JA; Karobath, M | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Heisler, S | 1 |
| Hattori, Y; Hazama, S; Kanno, M; Nakao, Y | 1 |
| Advenier, C; Naline, E; Renier, A | 1 |
| Garcia, ML; Kaczorowski, GJ; King, VF; Reuben, JP; Siegl, PK | 1 |
| Lovenberg, W; Robinson, PJ | 1 |
| Traber, J; Van Rooijen, LA | 1 |
| Conte-Camerino, D; De Luca, A; Lograno, M; Persichella, M | 1 |
| Karaki, H; Satake, N; Shibata, S | 1 |
| Bertaccini, G; Coruzzi, G; Poli, E | 2 |
| Ogawa, N; Ono, H | 1 |
| Louis, WJ; Rand, MJ; Story, DF; Tung, LH | 1 |
| Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A | 1 |
| Dietz, JR | 1 |
| Cornwell, MM; Gottesman, MM; Pastan, I | 1 |
| Bjøro, T; Gautvik, KM; Gordeladze, J; Haug, E; Iversen, JG; Ostberg, BC; Sand, O; Torjesen, PA | 1 |
| Höllt, V; Kley, N; Loeffler, JP; Pittius, CW | 1 |
| Kavaliers, M | 2 |
| Janis, RA; Sarmiento, JG; Shrikhande, AV; Triggle, DJ | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Matsumura, Y; Morimoto, S; Sasaki, Y; Shinyama, H; Uriu, T | 1 |
| Finkel, MS; Tallman, JF | 1 |
| Challoner-Hue, L; Steele, TH | 2 |
| Jonkman, FA; Korstanje, C; Van Kemenade, JE; Van Zwieten, PA | 1 |
| Ohshika, H; Takemura, H | 1 |
| Carboni, E; Wojcik, WJ | 1 |
| Kavaliers, M; Ossenkopp, KP | 1 |
| Coghlan, JP; Denton, DA; Johnson, EI; McDougall, JG; Scoggins, BA; Wright, RD | 1 |
| Boddeke, HW; Heynis, JB; van Zwieten, PA; Wilffert, B | 1 |
| Kabell, G | 1 |
| Dillon, JS; Nayler, WG | 1 |
| Dunn, SM | 2 |
| Huang, BS; McCumbee, WD; Wright, GL | 1 |
| Gandhi, VC; Jones, DJ | 1 |
| Aupetit, JF; Faucon, G; Lançon, JP; Lang, J; Timour, Q | 1 |
| Barnes, S; Davies, JA | 1 |
| Noble, EP; Oldham, SB; Ritchie, T | 1 |
| Huddart, H; Langton, PD | 1 |
| Calixto, JB; Rae, GA | 1 |
| Akahane, K; Chiba, S; Furukawa, Y; Ogiwara, Y | 1 |
| Billman, GE | 1 |
| Ogata, M; Ohe, M; Shirato, K; Takishima, T | 1 |
| Conlon, JM; Katsoulis, S | 1 |
| Chiu, M; Dionne, MA; Marsh, JD; Smith, TW | 1 |
| Gomi, Y; Suzuki, N | 1 |
| Blair-West, JR; Nelson, JF; Wright, RD | 1 |
| Bouchelouche, PN; Frederiksen, O; Hainau, B | 1 |
| Donowitz, M; Homaidan, FR; Sharp, GW; Weiland, GA | 1 |
| Alonso, MJ; Fernández-Alfonso, MS; Marín, J; Rico, I; Salaices, M | 1 |
| Beuckelmann, DJ; Wier, WG | 1 |
| Dutton, GR; Philibert, RA | 1 |
| Chiarini, A; Gualtieri, F; Mannhold, R; Romanelli, MN | 1 |
| Flockerzi, V | 1 |
| Hassid, A; Lermioglu, F; Yu, YM | 1 |
| Palmi, M; Sgaragli, G | 1 |
| Chang, CC; Chiou, LC; Hong, SJ; Huang, CY; Hwang, LL | 1 |
| Satoh, K; Taira, N; Wada, Y | 1 |
| Belin, C; Carriot, T; Doble, A; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 1 |
| Ishii, K; Taira, N; Yanagisawa, T | 1 |
| Berg, C; Spedding, M | 1 |
| Fischli, W; Hengartner, U; Holck, M | 1 |
| Bellemann, P | 1 |
| Groth, H; Locher, R; Neyses, L; Stimpel, M; Vetter, W | 1 |
| Lazdunski, M; Méaux, JP; Renaud, JF; Romey, G; Schmid, A | 1 |
| Asano, M; Imaizumi, Y; Ito, K; Nomura, Y; Uyama, Y; Watanabe, M | 1 |
| Abbe, R; Appel, SH; Bostwick, JR | 1 |
| Bastié, MJ; Bertrand, V; Pradayrol, L; Vaysse, N | 1 |
| Dusseau, J; Hutchins, PM | 1 |
| Dakshinamurti, K; Lal, KJ | 1 |
| Baeyens, JM; Barrios, M; Robles, I | 1 |
| Contreras, E; Hernández, A; Paeile, C; Pelissier, T; Pérez, H; Quijada, L; Soto-Moyano, R | 1 |
| Abman, SH; Cornfield, DN; McMurtry, IF; Rodman, DM; Stevens, T | 1 |
| Jiang, Y; Wang, XM; Wang, ZF; Zhang, WJ; Zhong, GG | 1 |
| Bégay, V; Bois, P; Collin, JP; Falcón, J; Lenfant, J | 1 |
| Katina, IE; Luk'ianenko, VI; Nasledov, GA | 1 |
| Cook, DI; Poronnik, P; Tuch, BE; Weinhaus, AJ | 1 |
| Bertolino, S; Medeiros, IA; Sassard, J; Zhang, BL | 1 |
| Filloux, FM; Fitts, RC; Skeen, GA; White, HS | 1 |
| Chang, JP; Jobin, RM; Neumann, CM; Van Goor, F; Wong, AO | 1 |
| Roldan, ER; Shi, QX | 1 |
| García, AG; Guantes, JM; Michelena, P; Montiel, C; Uceda, G | 1 |
| Kato, T; Kondo, A; Saito, M | 1 |
| Blanchard, J; Giuliano, AR; Nguyen, LD; Surendran, N | 1 |
| Ehrenstein, G; Fitzpatrick, LA; Pocotte, SL | 1 |
| Cai, BC; Chen, L; Lu, YM; Ma, C; Wu, H | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
| Prostran, M; Todorović, Z; Varagić, VM | 1 |
| Brito, G; Bustamante, S; Morales, MA; Paeile, C; Ponce, H; Silva, A | 1 |
| Martinez-Piñero, MG; Milanés, MV; Vargas, ML | 1 |
| Denborough, MA; Foster, PS | 1 |
| Hagiwara, S; Karaki, H; Mitsui, M | 1 |
| Akimoto, T; Ichida, S; Kishino, H; Matsuda, N; Nakazaki, S; Wada, T | 1 |
| Hurst, RD; McDermott, GF; Whiteside, CI | 1 |
| Ammälä, C; Bokvist, K; Dypbukt, J; Hallberg, A; Juntti-Berggren, L; Larsson, O; Nicotera, P; Orrenius, S; Rorsman, P; Wåhlander, K | 1 |
| Hume, RI; Lin, X; Nuttall, AL | 1 |
| Aksnes, G; Christensen, G; Leistad, E; Verburg, E | 1 |
| Birnbaumer, L; Hofmann, F; Ito, H; Klugbauer, N; Lacinová, L; Schuster, A | 1 |
| Bulgakova, NV; Limansky, YP; Pilyavskii, AI; Yakhnitsa, VA | 1 |
| Horváth, G; Kovács, M; Morvay, Z; Szikszay, M; Szilágyi, A | 1 |
| Bracke, M; Bruyneel, E; Castronovo, V; Charlier, C; Lechanteur, C; Mareel, M | 1 |
| Bardisa, L; Barra, E; Barrios, M; Demetrio, C; Martín, N; Pantoja, C; Sepúlveda, MJ; Valenzuela, J | 1 |
| Hu, Q; Huang, F; Shi, Y | 1 |
| Eusebi, F; Giovannelli, A; Lorenzon, P; Ragozzino, D; Ruzzier, F | 1 |
| Akishita, M; Eto, M; Hashimoto, M; Kim, S; Kozaki, K; Nagano, K; Ouchi, Y; Sudo, N; Toba, K; Watanabe, M; Yoo, HJ; Yoshizumi, M | 1 |
| Calderon, CL; Kolonias, D; Lampidis, TJ; Savaraj, N; Shi, YF; Tapiero, H | 1 |
| Pelleg, A; Xu, J; Zaim, S | 1 |
| Beyreuther, K; Masters, CL; Sáez-Valero, J; Sberna, G; Small, DH | 1 |
| Jan, CR; Li, HF; Wu, SN | 1 |
| Bufler, J; Choi, GC; Franke, C; Prinz, C; Schepp, W | 1 |
| Klein, G; Nawrath, H; Rupp, J; Shainberg, A; Wegener, JW | 1 |
| Kubo, T; Taguchi, K; Ueda, M | 1 |
| Kanaya, N; Kawana, S; Kimura, H; Matsumoto, M; Miyamoto, A; Namiki, A; Ohshika, H; Tsuchida, H | 1 |
| Apaydin, S; Ates, M; Gelal, A; Guven, H; Tuncok, Y | 1 |
| Anwar, M; Banister, RE; Feng, CJ; Kadowitz, PJ; Kaye, AD; Nossaman, BD | 1 |
| Beales, IL; Calam, J; Jordinson, M | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Kasama, M; Oguchi, T | 1 |
| Brust, PF; Hans, M; Harpold, MM; Prodanovich, P; Stauderman, KA; Urrutia, A; Washburn, MS; Williams, ME | 1 |
| Dedos, SG; Fugo, H | 1 |
| Chida, K; Ichiyama, A; Kanai, M; Nakamura, H; Oki, Y; Suda, T; Uchida, C; Xue, HH; Zhao, DM | 1 |
| Brochu, M; Picard, S; Simaan, M; St-Louis, J | 1 |
| Hayashi, M; Nakazato, Y; Saruta, T; Yamaji, Y | 1 |
| Care, AD; Wadhwa, DR | 1 |
| Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
| Brodacz, B; Holzer-Petsche, U; Horváth, G | 1 |
| Asano, M; Nomura, Y | 1 |
| Devlin, CL | 1 |
| Cathala, L; Chesnoy-Marchais, D | 1 |
| Amano, T; Hai-Du, Y; Katsura, M; Mohri, Y; Ohkuma, S; Sasa, M; Shuto, K; Tsujimura, A | 1 |
| Gaughan, JP; Houser, SR; Piacentino, V | 1 |
| Koizumi, N; Masui, H; Siogawa, K; Wakabayashi, I | 1 |
| Flameng, W; Macianskiene, R; Moccia, F; Mubagwa, K; Sipido, KR | 1 |
| Austin, O; Clunn, GF; Hughes, AD; Lymn, JS; Patel, MK | 1 |
| Damaj, MI | 1 |
| Damron, DS; Kanaya, N; Murray, PA | 1 |
| Denda, M; Fujiwara, S; Hibino, T | 1 |
| Abe, S; Chiba, S; Nakao, H; Ohkubo, Y; Ohtake, Y; Suyama, S | 1 |
| Minarovic, I; Zahradník, I; Zahradníková, A | 1 |
| Bendhack, LM; Rocha, ML | 1 |
| Hattori, T; Wang, PL | 1 |
| Jeppsson, B; Liu, Q; Melander, A; Thorlacius, H; Wang, Y; Zawadzki, A | 1 |
| Balezina, OP; Gaydukov, AE; Melnikova, SN | 1 |
| Butakova, SS; Nozdrachev, AD | 1 |
| Chang, IH; Han, JH; Kim, HJ; Kim, W; Lee, MY; Lee, SY; Myung, SC | 1 |
| Kobayashi, Y; Matsui, T; Tanaka, M; Wang, Z; Watanabe, S | 1 |
| Atan, S; Chung, YY; Dusting, G; Iskandar, F; Mehta, A; Ng, A; Shim, W; Sun, W; Wei, H; Wong, P | 1 |
| Benaim, G; Figarella, K; García-Marchán, Y; Reyes, C; Uzcanga, G | 1 |
| Ganellin, CR; Ouyang, M; Thomas, SA; Zhang, L | 1 |
| Chen, M; Pei, JM; Wang, QL; Wu, Q; Zhang, SM; Zhou, P | 1 |
| Gao, S; Huang, G; Lei, J; Wu, J; Wu, Q; Yan, N; Yan, Z; Zhao, Y | 1 |
| Artmann, AT; Artmann, G; Bayer, R; Creutz, T; Digel, I; Falkenstein, J; Hescheler, J | 1 |
| Forouzandehmehr, M; Hyttinen, J; Koivumäki, JT; Paci, M | 1 |
1 review(s) available for bay-k-8644 and verapamil
| Article | Year |
|---|---|
Ethanol exposure alters K+- but not bradykinin-induced dopamine release in PC12 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Gland Neoplasms; Animals; Bradykinin; Calcium Channels; Dopamine; Dose-Response Relationship, Drug; Ethanol; Osmolar Concentration; Pheochromocytoma; Potassium; Rats; Stimulation, Chemical; Verapamil | 1989 |
201 other study(ies) available for bay-k-8644 and verapamil
| Article | Year |
|---|---|
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Topics: Animals; Autophagy; Calcium Channels, L-Type; Clonidine; Cyclic AMP; Humans; Huntington Disease; Imidazoline Receptors; Minoxidil; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Type C Phospholipases; Verapamil | 2008 |
[The effect of calcium antagonists on cholesterol metabolism in human aortal intima cells and macrophage lines].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aorta; Cells, Cultured; Cholesterol; Cholesterol Esters; Humans; Hydrolysis; Kinetics; Macrophages; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Verapamil | 1992 |
Modulation of dihydropyridine-sensitive calcium channels in heart cells by fish oil fatty acids.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Dihydropyridines; Fatty Acids, Unsaturated; Fish Oils; Heart; In Vitro Techniques; Ion Channel Gating; Myocardial Contraction; Nitrendipine; Ouabain; Rats; Verapamil | 1992 |
Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aluminum; Animals; Calcium; Calcium Channels; Carbachol; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Drug Antagonism; Female; Fluorine; Guinea Pigs; Inositol Phosphates; Ionomycin; Isoproterenol; Myometrium; Nifedipine; Oxytocin; Pertussis Toxin; Receptors, Adrenergic, beta; Type C Phospholipases; Verapamil; Virulence Factors, Bordetella | 1992 |
Hypoxic contraction of pre-stretched human pulmonary artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adult; Aged; Arachidonic Acids; Culture Techniques; Humans; Lipoxygenase; Middle Aged; Nitroglycerin; Oxygen; Propranolol; Pulmonary Artery; Vasoconstriction; Verapamil | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Diltiazem; Drug Synergism; Flunarizine; Mice; Mice, Inbred DBA; Nimodipine; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Verapamil | 1992 |
Calcium channels are involved in the hypnotic-anesthetic action of dexmedetomidine in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics; Animals; Calcium Channels; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Hypnotics and Sedatives; Imidazoles; Male; Medetomidine; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1992 |
Effects of verapamil and Bay K 8644 on defibrillation energy requirements in dogs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Cardiac Catheterization; Dogs; Electric Countershock; Electrocardiography; Female; Male; Verapamil | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Atenolol; Calcium; Diltiazem; Endothelium, Vascular; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Potassium Chloride; Quinazolines; Rats; Rats, Inbred Strains; Stereoisomerism; Verapamil | 1992 |
Acute effect of 17 beta-estradiol on rabbit coronary artery contractile responses to endothelin-1.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Coronary Vessels; Endothelins; Estradiol; Female; In Vitro Techniques; Male; Rabbits; Vasoconstriction; Verapamil | 1992 |
Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia.
Topics: 2-Chloroadenosine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Electric Conductivity; Ganglia, Parasympathetic; Membrane Potentials; Neurons; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Theophylline; Verapamil | 1992 |
Inotropic effects of calcium antagonists in the cardiomyopathic Syrian hamster.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Depression, Chemical; Diltiazem; Gallopamil; Mesocricetus; Myocardial Contraction; Nifedipine; Stimulation, Chemical; Verapamil | 1992 |
Disparate effects of calcium channel blockers on pressure dependence of renin secretion and flow in the isolated perfused rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bumetanide; Calcium Channel Blockers; Glomerular Filtration Rate; In Vitro Techniques; Isoproterenol; Kidney; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Renin; Sodium; Verapamil | 1992 |
Effects of the novel calcium channel blocker, anipamil, on the isolated rabbit heart. Comparison with verapamil and gallopamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Female; Gallopamil; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Propylamines; Rabbits; Verapamil | 1992 |
Actions of two native GnRHs and protein kinase C modulators on goldfish pituitary cells. Studies on intracellular calcium levels and gonadotropin release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Biological Transport; Calcimycin; Calcium; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Fluorescence; Fura-2; Goldfish; Gonadotropin-Releasing Hormone; Pituitary Gland; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Verapamil | 1992 |
Inhibition of human mesangial cell proliferation by calcium channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dantrolene; Diltiazem; Glomerular Mesangium; Humans; Nifedipine; Platelet-Derived Growth Factor; Thrombin; Thymidine; Verapamil | 1990 |
Role of calcium and cAMP in heterologous up-regulation of the 1,25-dihydroxyvitamin D3 receptor in an osteoblast cell line.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenine; Adenylyl Cyclase Inhibitors; Calcitriol; Calcium; Cell Line; Colforsin; Cyclic AMP; Dinoprostone; Nitrendipine; Osteoblasts; Parathyroid Hormone; Receptors, Calcitriol; Receptors, Steroid; Up-Regulation; Verapamil | 1990 |
Effect of calcium-modifying drugs on glutamate dehydrogenase and isocitrate dehydrogenase activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Diltiazem; Glutamate Dehydrogenase; Homeostasis; In Vitro Techniques; Isocitrate Dehydrogenase; Kinetics; Mitochondria, Heart; Rats; Verapamil | 1990 |
Inotropic and calcium kinetic effects of calcium channel agonist and antagonist in isolated cardiac myocytes from cardiomyopathic hamsters.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding Sites; Calcium; Calcium Channels; Cardiomyopathies; Cricetinae; Heart; Homeostasis; Kinetics; Myocardial Contraction; Myocardium; Nifedipine; Verapamil | 1990 |
An endogenous Ca2+ channel agonist, endothelin-1, does not directly activate partially purified dihydropyridine-sensitive Ca2+ channel from cardiac muscle in a reconstituted system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Endothelins; Heart; Isradipine; Kinetics; Liposomes; Microsomes; Oxadiazoles; Proteolipids; Sarcolemma; Swine; Verapamil | 1990 |
Bay K 8644, modifier of calcium transport and energy metabolism in rat heart mitochondria: a new intracellular site of action.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Diphosphate; Animals; Biological Transport, Active; Calcium; Diltiazem; Energy Metabolism; Female; Glutamates; In Vitro Techniques; Malates; Mitochondria, Heart; NAD; Nitrendipine; Oxidation-Reduction; Oxygen Consumption; Rats; Ruthenium Red; Verapamil | 1990 |
Separate [3H]-nitrendipine binding sites in mitochondria and plasma membranes of bovine adrenal medulla.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane; Chromaffin System; Diltiazem; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mitochondria; Nitrendipine; Receptors, Nicotinic; Stereoisomerism; Subcellular Fractions; Verapamil | 1990 |
Differential effects of calcium antagonists and Bay K 8644 on contractile responses to exogenous noradrenaline and adrenergic nerve stimulation in the rabbit ear artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Calcium; Calcium Channel Blockers; Diltiazem; Ear, External; Electric Stimulation; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rabbits; Sympathetic Nervous System; Tetrodotoxin; Verapamil | 1990 |
Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Cardiomyopathies; Diabetes Mellitus, Experimental; Heart Rate; Hypertension; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Verapamil | 1991 |
Dual effect of 1.4-dihydropyridines on Ca2+ inflow into rat pancreatic islet cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Culture Media; Cytoplasm; Dose-Response Relationship, Drug; Fluorescence; Fura-2; Glucose; Islets of Langerhans; Nifedipine; Rats; Verapamil | 1991 |
Improved liver preservation for transplantation due to calcium channel blockade.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Allopurinol; Animals; Calcium Channel Blockers; Glutathione; Insulin; Liver; Liver Transplantation; Nifedipine; Organ Preservation; Organ Preservation Solutions; Rabbits; Raffinose; Solutions; Verapamil | 1991 |
[Structural effects in the sarcolemma of the cardiomyocytes under the action of modulators of the polyphosphoinositide system].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cattle; Fluorescent Dyes; Heart; In Vitro Techniques; Myocardium; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol Phosphates; Phosphatidylinositols; Prazosin; Sarcolemma; Verapamil | 1990 |
Effects of calcium-modifying agents on integrity of rabbit isolated gastric mucosal cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cell Separation; Diltiazem; Ethanol; Gastric Mucosa; In Vitro Techniques; Nifedipine; Protease Inhibitors; Rabbits; Trypan Blue; Verapamil | 1991 |
Parathyroid hormone and calcium: interactions in the control of renin secretion in the isolated, nonfiltering rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Egtazic Acid; In Vitro Techniques; Isoproterenol; Kidney; Kinetics; Male; Parathyroid Hormone; Peptide Fragments; Perfusion; Rats; Rats, Inbred Strains; Renin; Teriparatide; Verapamil | 1991 |
Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Cadmium; Calcium Channel Blockers; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Dihydropyridines; Electric Conductivity; Membrane Potentials; Nifedipine; Pertussis Toxin; Verapamil; Virulence Factors, Bordetella | 1991 |
Effects of calcium-free solution, calcium antagonists, and the calcium agonist BAY K 8644 on mechanical responses of skeletal muscle from patients susceptible to malignant hyperthermia.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Biopsy; Calcium Channel Blockers; Calcium Channels; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Isotonic Solutions; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Receptors, Nicotinic; Verapamil | 1991 |
Effects of calcium channel agonist and antagonists on calcium-dependent events in CA1 hippocampal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus; Male; Neurons; Nimodipine; omega-Conotoxin GVIA; Peptides, Cyclic; Rats; Rats, Inbred Strains; Synapses; Verapamil | 1991 |
Schistosoma mansoni: the role of calcium in the stimulation of cercarial proteinase release.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Endopeptidases; Extracellular Matrix; Fibroblasts; Linoleic Acid; Linoleic Acids; Oleic Acid; Oleic Acids; Proadifen; Ryanodine; Schistosoma mansoni; Verapamil | 1991 |
Voltage-dependent calcium currents in dissociated granule cells from rat cerebellum.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Bicuculline; Calcium Channels; Cerebellum; Electrophysiology; gamma-Aminobutyric Acid; Membrane Potentials; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Mice; Morphine Dependence; Naloxone; Nicardipine; Postural Balance; Substance Withdrawal Syndrome; Verapamil | 1991 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
A capacitative Ca2+ influx is required for sustained fluid secretion in sublingual mucous acini.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bumetanide; Calcium; Calcium Channel Blockers; Chlorides; Electric Conductivity; Kinetics; Male; Mouth Mucosa; Potassium; Rats; Sodium; Sublingual Gland; Verapamil | 1991 |
An experimental test of a model for repeated Ca2+ spikes in osteoblastic cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Cell Membrane; Electric Conductivity; Fourier Analysis; Kinetics; Membrane Potentials; Models, Biological; Nifedipine; Osteoblasts; Tumor Cells, Cultured; Verapamil | 1991 |
Effects of calcium modulators on vagally-mediated constriction in the guinea-pig isolated trachea.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bronchoconstrictor Agents; Cyclooxygenase Inhibitors; Electric Stimulation; Flurbiprofen; Guinea Pigs; In Vitro Techniques; Male; Nifedipine; Trachea; Vagus Nerve; Verapamil | 1991 |
Contraction of vascular smooth muscle induced by phorbol 12,13 dibutyrate in human and rat pulmonary arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atropine; Calcium; Humans; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Phentolamine; Phorbol 12,13-Dibutyrate; Potassium; Propranolol; Protein Kinase C; Pulmonary Artery; Rats; Tetrodotoxin; Trifluoperazine; Verapamil | 1991 |
Various Ca2+ entry blockers prevent glutamate-induced neurotoxicity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium Channel Blockers; Cerebellum; Dihydropyridines; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; Isradipine; Kainic Acid; Nerve Degeneration; Nervous System Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Action of organic antagonists on neuronal calcium currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Birds; Calcium; Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Ganglia, Spinal; Ion Channels; Nifedipine; Time Factors; Verapamil | 1985 |
The stimulatory action of the calcium channel agonist Bay K 8644 on isolated duodenal muscle. Antagonism by nifedipine and verapamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Duodenum; Gastrointestinal Motility; In Vitro Techniques; Ion Channels; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1985 |
The effect of dihydropyridine calcium agonists and antagonists on neuronal voltage sensitive calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aminoquinolines; Animals; Brain Chemistry; Calcium; Calcium Channel Blockers; Cell Line; Dihydropyridines; Electric Stimulation; Glioma; In Vitro Techniques; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Potassium; Pyridines; Rats; Synaptosomes; Verapamil | 1986 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
BAY-K-8644-stimulated cyclic GMP synthesis in mouse pituitary tumor cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenocorticotropic Hormone; Animals; Azides; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Isoproterenol; Mice; Nifedipine; Nitroprusside; Pituitary Neoplasms; Sodium Azide; Stimulation, Chemical; Verapamil | 1986 |
Inotropic effects of Ca2+ channel agonist and antagonists in neuraminidase-treated left atria of rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Heart Atria; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Myocardial Contraction; N-Acetylneuraminic Acid; Neuraminidase; Nifedipine; Rats; Sialic Acids; Verapamil | 1986 |
Effects of Bay K 8644 on contraction of the human isolated bronchus and guinea-pig isolated trachea.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Bronchi; Calcium; Calcium Channel Blockers; Guinea Pigs; Histamine; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nicardipine; Nifedipine; Potassium Chloride; Trachea; Verapamil | 1986 |
Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Diltiazem; Dithiothreitol; Ethylmaleimide; Female; Guinea Pigs; Hydrogen-Ion Concentration; Iodocyanopindolol; Male; Myocardium; Nifedipine; Nitrendipine; Ouabain; Pindolol; Receptors, Nicotinic; Sodium; Sodium-Potassium-Exchanging ATPase; Stereoisomerism; Temperature; Verapamil | 1986 |
Calcium channel agonists and antagonists regulate protein phosphorylation in intact synaptosomes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Corpus Striatum; Ion Channels; Nerve Tissue Proteins; Nifedipine; Phosphorus; Phosphorus Radioisotopes; Phosphorylation; Synaptosomes; Verapamil | 1986 |
Muscarinic cholinergic enhancement of inositide turnover in cerebral nerve endings is not mediated by calcium uptake.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcimycin; Calcium; Carbachol; Cinnarizine; Flunarizine; Male; Nerve Endings; Nicotinic Acids; Nifedipine; Nimodipine; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Inbred Strains; Verapamil; Veratridine | 1986 |
[Effects of a new 1,4-dihydropyridine, Bay K 8644, on smooth muscle organs isolated from the guinea pig].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Verapamil | 1986 |
Mechanism of barium-induced contraction in the vascular smooth muscle of rabbit aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Dose-Response Relationship, Drug; Ion Channels; Lanthanum; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Verapamil | 1986 |
Bay K 8644 and acetylcholine: different interaction with calcium ions in the rat duodenal muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Drug Interactions; Gastrointestinal Motility; In Vitro Techniques; Ion Channels; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Different effects of noradrenaline, angiotensin II and BAY K 8644 on the abolition of autoregulation of renal blood flow by verapamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Blood Pressure; Dogs; Female; Homeostasis; Male; Norepinephrine; Renal Circulation; Verapamil | 1986 |
Cardiac alpha-adrenoceptors: postjunctional and prejunctional.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Animals; Calcium; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; Idazoxan; In Vitro Techniques; Labetalol; Methoxamine; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stimulation, Chemical; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
Effects of a calcium channel agonist on renin release from perfused rat kidneys.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Ion Channels; Isoproterenol; Kidney; Male; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Renin; Verapamil | 1986 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma; Cell Line; Diltiazem; Drug Resistance; Glycoproteins; Humans; Nitrendipine; Quinidine; Verapamil; Vinblastine | 1987 |
Vasoactive intestinal peptide and peptide with N-terminal histidine and C-terminal isoleucine increase prolactin secretion in cultured rat pituitary cells (GH4C1) via a cAMP-dependent mechanism which involves transient elevation of intracellular Ca2+.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Membrane Potentials; Peptide PHI; Pituitary Gland; Prolactin; Rats; Secretory Rate; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide; Verapamil | 1987 |
Involvement of ion channels in the induction of proenkephalin A gene expression by nicotine and cAMP in bovine chromaffin cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Animals; Calcium; Cattle; Cells, Cultured; Chromaffin System; Colforsin; Cyclic AMP; Enkephalins; Gallopamil; Gene Expression Regulation; Ion Channels; Nicotine; Nifedipine; Protein Precursors; RNA, Messenger; Sodium; Tubocurarine; Verapamil | 1987 |
Aggression and defeat-induced opioid analgesia displayed by mice are modified by calcium channel antagonists and agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Calcium Channel Blockers; Diltiazem; Mice; Nifedipine; Pain; Reaction Time; Verapamil | 1987 |
[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Diltiazem; Edetic Acid; Female; Heart Ventricles; Hot Temperature; Kinetics; Lipolysis; Mathematics; Membranes; Myocardium; Nitrendipine; Propylamines; Rabbits; Tiapamil Hydrochloride; Verapamil | 1987 |
Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cell Line; Diltiazem; Drug Interactions; Ethanol; Flunarizine; Ion Channels; Nifedipine; Verapamil | 1987 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil | 1987 |
Inhibitory effects of calcium channel agonists on renin release from rat kidney cortical slices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dose-Response Relationship, Drug; Imidazoles; Ion Channels; Kidney Cortex; Male; Nifedipine; Pyridines; Rats; Rats, Inbred Strains; Renin; Trifluoperazine; Verapamil | 1987 |
Solubilization of calcium channel antagonist binding sites from rat brain.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain Chemistry; Calcium Channels; Cholic Acids; Kinetics; Male; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Solubility; Verapamil | 1987 |
Dihydropyridine calcium antagonists and agonists in the isolated perfused Dahl rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Hypertension, Renal; In Vitro Techniques; Ion Channels; Kidney; Male; Nitrendipine; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Renal Circulation; Sodium Chloride; Verapamil | 1987 |
Bay k 8644, a calcium entry promoter, as an antidote in verapamil intoxication in rabbits.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Aminopyridines; Animals; Antidotes; Atrioventricular Node; Blood Pressure; Cardiovascular Agents; Electrocardiography; Female; Heart Rate; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Male; Pyridines; Rabbits; Verapamil | 1987 |
Effects of Ca2+ agonist and antagonists on cytosolic free Ca2+ concentration: studies on Ca2+ channels in rat parotid cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Ion Channels; Kinetics; Male; Methoxamine; Nicardipine; Parotid Gland; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Dihydropyridine binding sites regulate calcium influx through specific voltage-sensitive calcium channels in cerebellar granule cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cations, Divalent; Cell Membrane; Cells, Cultured; Cerebellum; Diltiazem; Electrophysiology; Ion Channels; Neurons; Nifedipine; Nitrendipine; Potassium; Rats; Receptors, Nicotinic; Verapamil | 1988 |
Increased vascular response to calcium channel agonist by Dahl S rat kidney.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Glomerular Filtration Rate; In Vitro Techniques; Kidney; Male; Nitrendipine; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Reference Values; Renal Circulation; Sodium, Dietary; Species Specificity; Verapamil | 1988 |
Magnetic fields inhibit opioid-mediated 'analgesic' behaviours of the terrestrial snail, Cepaea nemoralis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Diltiazem; Ion Channels; Magnetics; Morphine; Naloxone; Nifedipine; Nociceptors; Pyrrolidines; Snails; Temperature; Verapamil | 1988 |
Role of Ca2+ in response of aldosterone to stimulation by angiotensin II in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Hydrocortisone; Lanthanum; Nifedipine; Nisoldipine; Sheep; Verapamil | 1988 |
Investigation of the mechanism of negative inotropic activity of some calcium antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Bepridil; Calcimycin; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Female; Flunarizine; Guinea Pigs; In Vitro Techniques; Lidoflazine; Male; Myocardial Contraction; Pyrrolidines; Verapamil | 1988 |
Modulation of conduction slowing in ischemic rabbit myocardium by calcium-channel activation and blockade.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Coronary Disease; Heart Conduction System; In Vitro Techniques; Ion Channels; Membrane Potentials; Microelectrodes; Rabbits; Regression Analysis; Verapamil | 1988 |
The Ca2+ -antagonist and binding properties of the phenylalkylamine, anipamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Chloride; Electric Stimulation; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Propylamines; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Multiple calcium channels in synaptosomes: voltage dependence of 1,4-dihydropyridine binding and effects on function.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Male; Nitrendipine; Oxadiazoles; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Verapamil | 1988 |
Bay K 8644-like contractile effects of a peptide isolated from spontaneously hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Peptides; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Verapamil | 1988 |
Identification and characterization of [3H]nitrendipine binding sites in rat spinal cord.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Kinetics; Male; Nifedipine; Nitrendipine; Quinacrine; Rats; Rats, Inbred Strains; Spinal Cord; Trifluoperazine; Verapamil | 1988 |
Biphasic dose-response relationship observed with Bay k 8644 on atrioventricular nodal conduction inhibited by verapamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrioventricular Node; Calcium; Dogs; Dose-Response Relationship, Drug; Female; Heart Conduction System; Infusions, Intravenous; Male; Verapamil | 1988 |
The effects of calcium channel agonists and antagonists on the release of endogenous glutamate from cerebellar slices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cerebellum; Diltiazem; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Ethanol; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome; Verapamil | 1988 |
Voltage and time dependency of calcium mediated phasic and tonic responses in rat vas deferens smooth muscle--the effect of some calcium agonist and antagonist agents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Electrophysiology; In Vitro Techniques; Lanthanum; Male; Manganese; Muscle Contraction; Muscle, Smooth; Papaverine; Potassium; Rats; Rats, Inbred Strains; Time Factors; Vas Deferens; Verapamil | 1988 |
Interactions of calcium antagonists and the calcium channel agonist Bay K 8644 on neurotransmission of the mouse isolated vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Drug Interactions; Electric Stimulation; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Synaptic Transmission; Vas Deferens; Verapamil; Yohimbine | 1989 |
Different antagonism of the positive chronotropic and inotropic responses of the isolated, blood-perfused dog atrium to Bay k 8644 by nicardipine and verapamil.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Function; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Heart Atria; Heart Rate; Myocardial Contraction; Nicardipine; Propranolol; Verapamil | 1988 |
Effect of calcium channel antagonists on susceptibility to sudden cardiac death: protection from ventricular fibrillation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Death, Sudden; Dogs; Hemodynamics; Magnesium Sulfate; Nifedipine; Ventricular Fibrillation; Verapamil | 1989 |
Effects of verapamil and BAY K 8644 on the hypoxic contraction of the isolated human pulmonary artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Oxygen Consumption; Pulmonary Artery; Verapamil | 1989 |
Calcitonin gene-related peptides relax guinea pig and rat gastric smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Rats; Rats, Inbred Strains; Stomach; Verapamil | 1989 |
A dihydropyridine calcium channel blocker with phosphodiesterase inhibitory activity: effects on cultured vascular smooth muscle and cultured heart cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Nifedipine; Phosphodiesterase Inhibitors; Rats; Verapamil | 1988 |
Effects of calcium-entry modulators on the biphasic neurogenic contractions in the circular muscle of guinea pig vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Prazosin; Vas Deferens; Verapamil | 1989 |
On the relation of calcium to ovine parotid secretion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Flow Velocity; Calcimycin; Calcium; Egtazic Acid; Infusions, Parenteral; Parotid Gland; Saliva; Sheep; Trifluoperazine; Verapamil | 1989 |
Effect of BAY K 8644 on cytosolic free calcium in isolated rabbit gall-bladder epithelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzofurans; Calcium; Cell Separation; Cytophotometry; Cytosol; Dose-Response Relationship, Drug; Epithelium; Female; Fura-2; Gallbladder; Rabbits; Verapamil | 1989 |
Voltage-dependent calcium channels in skeletal muscle transverse tubules. Measurements of calcium efflux in membrane vesicles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Carbocyanines; Cell Membrane; Dihydropyridines; Edetic Acid; Fluorescent Dyes; Isradipine; Lanthanum; Membrane Potentials; Muscles; Nitrendipine; Oxadiazoles; Potassium; Rabbits; Verapamil | 1989 |
Two calcium channels in basolateral membranes of rabbit ileal epithelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorides; Diltiazem; Egtazic Acid; Electric Conductivity; Epithelium; Ileum; Male; Nifedipine; Nitrendipine; Rabbits; Sodium; Verapamil | 1989 |
Vasoconstrictor effect of the Ca2+ agonist Bay K 8644 on human cerebral arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Blockers; Cerebral Arteries; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nifedipine; Vasoconstrictor Agents; Verapamil | 1989 |
Mechanism of release of calcium from sarcoplasmic reticulum of guinea-pig cardiac cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Myocardium; Ryanodine; Sarcolemma; Sarcoplasmic Reticulum; Tetrodotoxin; Verapamil | 1988 |
Dihydropyridines modulate K+-evoked amino acid and adenosine release from cerebellar neuronal cultures.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine; Amino Acids; Animals; Calcium Channel Blockers; Cells, Cultured; Cerebellum; Dihydropyridines; Potassium; Rats; Verapamil | 1989 |
A search for calcium-channel activators in the verapamil series.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Chemical Phenomena; Chemistry; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Rabbits; Verapamil | 1989 |
Molecular properties of voltage-activated calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Azides; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA; Glycoproteins; Muscles; Phosphorylation; Protein Conformation; Protein Kinases; Receptors, Nicotinic; Verapamil | 1989 |
Modulation of Ca by agents affecting voltage-sensitive Ca channels in mesangial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Cytosol; Glomerular Mesangium; Kinetics; Lanthanum; Male; Membrane Potentials; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Verapamil | 1989 |
Effect of calcium-channel blockers and salbutamol on the isolated mare uterus--interaction with the calcium agonist Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Albuterol; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Female; Horses; Nifedipine; Uterine Contraction; Uterus; Verapamil | 1989 |
Hyperthermia induced in rabbits by organic calcium antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Body Temperature; Calcium Channel Blockers; Cinnarizine; Dose-Response Relationship, Drug; Endotoxins; Fever; Male; Nifedipine; Rabbits; Verapamil | 1989 |
Nicardipine inhibits axon conduction but causes dual changes of acetylcholine release in the mouse motor nerve.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Action Potentials; Animals; Axonal Transport; Axons; Chick Embryo; Diaphragm; Diltiazem; Female; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Motor Neurons; Muscle Contraction; Nicardipine; Nifedipine; Sodium Channels; Succinylcholine; Verapamil | 1989 |
Is antagonism by Bay k 8644 of the negative dromotropic effect of nifedipine pharmacological?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrioventricular Node; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Female; Heart Conduction System; Male; Manganese; Nadolol; Nifedipine; Perfusion; Propanolamines; Tetrodotoxin; Verapamil | 1985 |
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Heart; Ion Channels; Isoquinolines; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Receptors, GABA-A; Tetraethylammonium Compounds; Verapamil | 1985 |
Differential antagonism by Bay k 8644, a dihydropyridine calcium agonist, of the negative inotropic effects of nifedipine, verapamil, diltiazem and manganese ions in canine ventricular muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart; In Vitro Techniques; Male; Manganese; Myocardial Contraction; Nifedipine; Verapamil | 1985 |
Interactions between a "calcium channel agonist", Bay K 8644, and calcium antagonists differentiate calcium antagonist subgroups in K+-depolarized smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Male; Muscle, Smooth; Neuromuscular Depolarizing Agents; Nifedipine; Potassium; Verapamil | 1984 |
Effects of temperature and allosteric modulators on [3H] nitrendipine binding: methods for detecting potential Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Animals; Benzothiazoles; Binding Sites; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Microsomes; Myocardium; Nifedipine; Nitrendipine; Propylamines; Temperature; Thiazoles; Tiapamil Hydrochloride; Verapamil | 1984 |
Interaction of the calcium channel activating 3H-BAY K 8644 and inhibiting 3H-verapamil with specific receptor sites on cultured beating myocardial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Calcium Channel Blockers; Cells, Cultured; Kinetics; Myocardial Contraction; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Receptors, Drug; Verapamil | 1984 |
Human red blood cells--an ideal model system for the action of calcium agonists and antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Erythrocytes; Humans; Ion Channels; Nicardipine; Nifedipine; Nitrendipine; Pyridines; Stimulation, Chemical; Verapamil | 1984 |
Activation of the voltage-dependent Ca2+ channel in rat heart cells by dihydropyridine derivatives.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bepridil; Calcium; Dose-Response Relationship, Drug; Ion Channels; Myocardium; Nifedipine; Pyridines; Pyrrolidines; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1984 |
Increased function of voltage-dependent Ca++ channels and Ca(++)-activated K+ channels in resting state of femoral arteries from spontaneously hypertensive rats at prehypertensive stage.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Age Factors; Animals; Apamin; Calcium; Calcium Channel Blockers; Calcium Channels; Charybdotoxin; Femoral Artery; Hypertension; Ion Channel Gating; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Peptides; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Scorpion Venoms; Verapamil | 1995 |
Modulation of acetylcholine release in rat hippocampus by amino alcohols and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium; Cerebral Cortex; Choline; Corpus Striatum; Diltiazem; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Flunarizine; Hippocampus; In Vitro Techniques; Male; Nifedipine; Osmolar Concentration; Potassium Chloride; Propanolamines; Pyrrolidines; Rats; Rats, Inbred F344; Verapamil | 1993 |
Inhibition of gastrin-induced proliferation of AR4-2J cells by calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cell Division; Cell Line; Dose-Response Relationship, Drug; Gastrins; Kinetics; Nifedipine; Pancreatic Neoplasms; Rats; Tumor Cells, Cultured; Verapamil | 1994 |
Calcium entry blockers stimulate vasoproliferation on the chick chorioallantoic membrane.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allantois; Animals; Cell Division; Chick Embryo; Chorion; Dose-Response Relationship, Drug; Nifedipine; Nimodipine; Verapamil | 1993 |
Calcium channels in vitamin B6 deficiency-induced hypertension.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Diltiazem; Hypertension; Male; Nicotinic Acids; Nifedipine; Oxadiazoles; Rats; Rats, Sprague-Dawley; Verapamil; Vitamin B 6 Deficiency | 1993 |
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Behavior, Animal; Calcium Channels; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Implants; Female; Ileum; In Vitro Techniques; Isomerism; Mice; Muscle Contraction; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil; Yohimbine | 1993 |
Calcium channel modulators modify K opioid-induced inhibition of C-fiber-evoked spinal reflexes in rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Injections, Spinal; Nerve Fibers; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Reflex; Spinal Cord; Synaptic Transmission; Verapamil | 1993 |
Acute hypoxia causes membrane depolarization and calcium influx in fetal pulmonary artery smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acute Disease; Animals; Calcium; Cell Membrane; Cells, Cultured; Electrophysiology; Fetus; Fluorescence; Hypoxia; Manganese; Muscle, Smooth; Pulmonary Artery; Ryanodine; Sheep; Verapamil | 1994 |
[Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Cells, Cultured; Ginsenosides; Myocardium; Panax; Plants, Medicinal; Rats; Rats, Wistar; Triterpenes; Verapamil | 1994 |
Calcium and melatonin production in dissociated trout pineal photoreceptor cells in culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin; Calcium; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Female; Melatonin; Nifedipine; Photoreceptor Cells; Pineal Gland; Time Factors; Trout; Verapamil | 1994 |
[The effect of calcium current blockers on potential-dependent potassium currents of cultured frog developing skeletal muscle cells].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cells, Cultured; Membrane Potentials; Muscle, Skeletal; Nifedipine; Potassium; Quinidine; Rana temporaria; Verapamil | 1994 |
Insulin secretagogues, but not glucose, stimulate an increase in [Ca2+]i in the fetal rat beta-cell.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arginine; Calcium; Cells, Cultured; Diazoxide; Female; Fetus; Glipizide; Glucose; Glyceraldehyde; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Pancreas; Rats; Rats, Wistar; Verapamil | 1995 |
Pressure control of renal renin release in Lyon hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Diet, Sodium-Restricted; Hydralazine; Hypertension; In Vitro Techniques; Kidney; Male; Rats; Rats, Inbred Strains; Renin; Time Factors; Verapamil | 1994 |
The dihydropyridine nitrendipine inhibits [3H]MK 801 binding to mouse brain sections.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analysis of Variance; Animals; Autoradiography; Binding, Competitive; Brain; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Nifedipine; Nimodipine; Nitrendipine; Software; Verapamil | 1994 |
Signal transduction pathways in GnRH- and dopamine D1-stimulated growth hormone secretion in the goldfish.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Colforsin; Cyclic AMP; Dopamine; Goldfish; Gonadotropin-Releasing Hormone; Growth Hormone; Phospholipases A; Phospholipases A2; Pituitary Gland; Protein Kinase C; Signal Transduction; Verapamil | 1994 |
Evidence that a GABAA-like receptor is involved in progesterone-induced acrosomal exocytosis in mouse spermatozoa.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acrosome; Animals; Bicuculline; Calcium Channels; Exocytosis; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nifedipine; Progesterone; Receptors, GABA-A; Sperm Capacitation; Spermatozoa; Verapamil | 1995 |
Effects of Ca2+ channel antagonist subtypes on mitochondrial Ca2+ transport.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cattle; Diltiazem; Flunarizine; In Vitro Techniques; Mitochondria; Nitrendipine; Verapamil | 1995 |
Effects of magnesium ions on detrusor contraction in rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Carbachol; Female; In Vitro Techniques; Intracellular Fluid; Magnesium; Magnesium Chloride; Muscle Contraction; Potassium Chloride; Rats; Rats, Wistar; Stimulation, Chemical; Tetrodotoxin; Urinary Bladder; Verapamil | 1995 |
Mechanisms of acylcarnitine-mediated enhancement of calcium transport in the Caco-2 cell monolayer model.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Biological Transport; Calcium; Calcium Channels; Carnitine; Cell Line; Dose-Response Relationship, Drug; Kinetics; Nifedipine; Time Factors; Verapamil | 1995 |
Role of calcium channels in parathyroid hormone secretion.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cattle; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Ionomycin; Isotope Labeling; Nicotinic Acids; Nifedipine; Oxadiazoles; Parathyroid Glands; Parathyroid Hormone; Pertussis Toxin; Phosphorylation; Potassium; Radioimmunoassay; Stereoisomerism; Verapamil; Virulence Factors, Bordetella | 1995 |
[Single channel analysis of aconitine blockade of calcium channels in rat myocardiocytes].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aconitine; Animals; Animals, Newborn; Calcium Channel Blockers; Cells, Cultured; Myocardium; Rats; Rats, Wistar; Verapamil | 1995 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
The effect of nickel chloride on the isolated hemidiaphragm of the rat.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Colforsin; Diaphragm; Electric Stimulation; Female; In Vitro Techniques; Isometric Contraction; Lidocaine; Male; Nickel; Rats; Time Factors; Verapamil | 1995 |
Vasorelaxant effect of the analgesic clonixin on rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Clonixin; Drug Interactions; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Sprague-Dawley; Verapamil | 1995 |
L-type Ca2+ channel ligands modulate morphine effects on the hypothalamus-pituitary-adrenocortical axis in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Corticosterone; Dopamine; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Neurosecretory Systems; Nimodipine; Norepinephrine; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Potassium Chloride; Sarcoplasmic Reticulum; Swine; Verapamil | 1993 |
Effects of felodipine, nifedipine and verapamil on cytosolic Ca2+ and contraction in vascular smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cytosol; Felodipine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Rats; Rats, Wistar; Verapamil | 1993 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Bucladesine; Cell Differentiation; Cell Membrane; Diltiazem; Glioma; Hybrid Cells; Isradipine; Mollusk Venoms; Neuroblastoma; Nitrendipine; omega-Conotoxin GVIA; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1993 |
Isolated rat glomerular cells demonstrate L-type Ca(2+)-channel activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Glomerular Mesangium; Gramicidin; Ion Channel Gating; Kidney Glomerulus; Male; Membrane Potentials; Potassium Chloride; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Increased activity of L-type Ca2+ channels exposed to serum from patients with type I diabetes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Apoptosis; Calcium; Calcium Channels; Diabetes Mellitus, Type 1; DNA Damage; Humans; Immunoglobulin M; Islets of Langerhans; Membrane Potentials; Mice; Pituitary Neoplasms; Tumor Cells, Cultured; Verapamil | 1993 |
Dihydropyridines and verapamil inhibit voltage-dependent K+ current in isolated outer hair cells of the guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Cochlea; Guinea Pigs; Hair Cells, Auditory, Outer; Membrane Potentials; Nifedipine; Nimodipine; Patch-Clamp Techniques; Potassium Channel Blockers; Quinine; Verapamil | 1995 |
Atrial contractile dysfunction after short-term atrial fibrillation is reduced by verapamil but increased by BAY K8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Atrial Fibrillation; Calcium Channel Agonists; Female; Heart Atria; Lactates; Lactic Acid; Male; Myocardial Contraction; Phosphocreatine; Swine; Verapamil | 1996 |
The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Line; Humans; Ion Channel Gating; Isradipine; Mibefradil; Molecular Sequence Data; Muscle Proteins; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Tetrahydronaphthalenes; Transfection; Verapamil | 1996 |
Modulation of the activity of midbrain central gray substance neurons by calcium channel agonists and antagonists in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cell Count; In Vitro Techniques; Membrane Potentials; Mesencephalon; Nifedipine; Rats; Time Factors; Verapamil | 1996 |
Drugs acting on calcium channels modulate the diuretic and micturition effects of dexmedetomidine in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Blood Pressure; Calcium Channel Agonists; Calcium Channel Blockers; Diuresis; Imidazoles; Male; Medetomidine; Rats; Rats, Wistar; Ultrasonography; Urinary Bladder; Urination; Verapamil | 1996 |
Enhancement of tamoxifen-induced E-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cadherins; Calcium Channel Agonists; Calcium Channel Blockers; Cell Aggregation; Humans; Nifedipine; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1996 |
Involvement of calcium in the cardiac depressant actions of a garlic dialysate.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dialysis; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Garlic; Heart Atria; Male; Myocardial Contraction; Nifedipine; Plant Extracts; Plants, Medicinal; Rats; Verapamil | 1997 |
Inhibition of Toosendanin on the delayed rectifier potassium current in neuroblastoma x glioma NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glioma; Hybrid Cells; Mice; Neuroblastoma; Neuromuscular Blocking Agents; Nifedipine; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1997 |
Spontaneous and repetitive calcium transients in C2C12 mouse myotubes during in vitro myogenesis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Apamin; Caffeine; Calcium; Cell Differentiation; Cell Line; Cytosol; Egtazic Acid; Kinetics; Membrane Potentials; Mice; Microscopy, Confocal; Microscopy, Video; Muscle, Skeletal; Oscillometry; Potassium Chloride; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1997 |
Augmented Ca2+ influx is involved in the mechanism of enhanced proliferation of cultured vascular smooth muscle cells from spontaneously diabetic Goto-Kakizaki rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Aorta, Thoracic; Blood Glucose; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Count; Cell Division; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin; Male; Muscle, Smooth, Vascular; Nicardipine; Rats; Rats, Wistar; Vasoconstrictor Agents; Verapamil | 1997 |
Accumulation of simple organic cations correlates with differential cytotoxicity in multidrug-resistant and -sensitive human and rodent cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cell Line; Drug Resistance, Multiple; Guanidine; Guanidines; Humans; Mice; Pyridinium Compounds; Verapamil | 1997 |
Effects of pinacidil, verapamil, and heart rate on afterdepolarizations in the guinea-pig heart in vivo.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium Channel Blockers; Cesium; Chlorides; Digoxin; Female; Guanidines; Guinea Pigs; Heart; Heart Rate; Male; Pinacidil; Stereoisomerism; Verapamil | 1996 |
The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholinesterase; Amyloid beta-Peptides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinoma, Embryonal; Diltiazem; Gene Expression Regulation, Enzymologic; Kinetics; Marine Toxins; Nifedipine; Oxocins; Peptide Fragments; Tumor Cells, Cultured; Verapamil | 1997 |
Characteristics of store-operated Ca(2+)-permeable current in monocytic U937 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Line; Cell Membrane; Electrophysiology; Membrane Potentials; Monocytes; Nifedipine; Patch-Clamp Techniques; Rats; Verapamil | 1997 |
Voltage-gated Ca2+ currents in rat gastric enterochromaffin-like cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Enterochromaffin-like Cells; Female; Gastric Fundus; Gastric Mucosa; Histamine; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Verapamil | 1998 |
Open state block by fendiline of L-type Ca++ channels in ventricular myocytes from rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Female; Fendiline; Heart; Male; Rats; Rats, Sprague-Dawley; Verapamil | 1998 |
L-type calcium channels in vascular smooth muscle cells from spontaneously hypertensive rats: effects of calcium agonist and antagonist.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Male; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verapamil | 1998 |
Ca2+ channel modulation alters halothane-induced depression of ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Anesthetics, Inhalation; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Drug Synergism; Halothane; Heart Ventricles; Isradipine; Myocardial Contraction; Myocardium; Nifedipine; Rats; Rats, Wistar; Sarcolemma; Verapamil | 1998 |
The effects of 4-aminopyridine and Bay K 8644 on verapamil-induced cardiovascular toxicity in anesthetized rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Blood Pressure; Bradycardia; Calcium Channel Agonists; Calcium Channel Blockers; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Hypotension; Male; Random Allocation; Rats; Rats, Wistar; Verapamil | 1998 |
Pulmonary vasodilation by ketamine is mediated in part by L-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adamantane; Anesthetics, Dissociative; Animals; Arachidonic Acid; Arginine; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ketamine; Lung; Male; Meclofenamic Acid; Morpholines; Potassium Channels; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation; Verapamil | 1998 |
Soybean agglutinin stimulated cholecystokinin release from cultured rabbit jejunal cells requires calcium influx via L-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Separation; Cells, Cultured; Cholecystokinin; Colforsin; Enzyme Activation; Jejunum; Lectins; Male; Phenylalanine; Plant Lectins; Protein Kinase C; Rabbits; Radioimmunoassay; Somatostatin; Soybean Proteins; Staurosporine; Verapamil | 1998 |
Effects of low temperature on the chronotropic and inotropic responses to zatebradine, E-4031 and verapamil in isolated perfused dog atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Calcium Channel Agonists; Cardiovascular Agents; Cold Temperature; Dogs; Dose-Response Relationship, Drug; Heart Atria; Hypothermia, Induced; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Perfusion; Piperidines; Pyridines; Verapamil | 1998 |
Structure and functional characterization of a novel human low-voltage activated calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amiloride; Animals; Barium; Benzimidazoles; Blotting, Northern; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, T-Type; Cells, Cultured; Cloning, Molecular; Diuretics; DNA, Complementary; Electric Stimulation; Electrophysiology; Humans; Ion Channel Gating; Kidney; Kinetics; Membrane Potentials; Mibefradil; Molecular Sequence Data; Nickel; Nimodipine; Oocytes; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Tetrahydronaphthalenes; Transcription, Genetic; Verapamil; Xenopus | 1999 |
Interactions between Ca2+ and cAMP in ecdysteroid secretion from the prothoracic glands of Bombyx mori.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Bombyx; Bucladesine; Calcimycin; Calcium; Colforsin; Cyclic AMP; Drug Interactions; Ecdysterone; Enzyme Inhibitors; Phosphodiesterase Inhibitors; Second Messenger Systems; Signal Transduction; Thionucleotides; Verapamil | 1999 |
Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Anti-Bacterial Agents; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Erythromycin; Estrenes; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Membranes; Lung; Nickel; Potassium Chloride; Protein Isoforms; Pyrrolidinones; Receptors, Purinergic P2; Receptors, Purinergic P2X2; Tumor Cells, Cultured; Uridine Triphosphate; Verapamil | 2000 |
Functional alteration of dihydropyridine-sensitive Ca(2+) channels in the adrenal glomerulosa of pregnant rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Cell Membrane; Female; Nifedipine; Nitrendipine; Potassium Chloride; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Tritium; Verapamil; Zona Glomerulosa | 2000 |
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcimycin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Carcinogens; Cells, Cultured; Dihydropyridines; Gene Expression; Genes, Reporter; Glomerular Mesangium; Humans; Ionophores; Luciferases; NF-kappa B; Nifedipine; Nitrophenols; Organophosphorus Compounds; Tetradecanoylphorbol Acetate; Verapamil | 2000 |
The absorption of calcium ions from the ovine reticulo-rumen.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Absorption; Animals; Bicarbonates; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Epithelium; Fatty Acids, Volatile; Hydrogen-Ion Concentration; In Vitro Techniques; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Reticulum; Rumen; Sheep; Verapamil | 2000 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Role of calcium channels in the spinal transmission of nociceptive information from the mesentery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Clonidine; Dose-Response Relationship, Drug; Female; Mesentery; Morphine; omega-Conotoxins; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; Verapamil | 2001 |
Calcium buffering of resting, voltage-dependent Ca2+ influx by sarcoplasmic reticulum in femoral arteries from spontaneously hypertensive rats at prehypertensive stage.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Calcium-Transporting ATPases; Enzyme Inhibitors; Femoral Artery; Hypertension; Indoles; Male; Muscle Contraction; Nifedipine; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ryanodine; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thapsigargin; Verapamil | 2001 |
5-Hydroxytryptamine stimulates net Ca2+ flux in the ventricular muscle of a mollusc (Busycon canaliculatum) during cardioexcitation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Enzyme Inhibitors; Heart; Heart Ventricles; In Vitro Techniques; Indoles; Ionophores; Mollusca; Myocardium; Serotonin; Ventricular Function; Verapamil | 2001 |
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chloride Channels; Dihydropyridines; Drug Interactions; Glycine; Neural Inhibition; Neurons; Nicardipine; Nifedipine; Nitrendipine; Rats; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Synaptic Transmission; Verapamil | 2001 |
Up-regulation of L-type voltage-dependent calcium channels after long term exposure to nicotine in cerebral cortical neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Blotting, Western; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cerebral Cortex; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Ganglionic Stimulants; Immunoblotting; Kinetics; Mice; Neurons; Nicotine; Potassium Chloride; Protein Binding; RNA, Messenger; Time Factors; Up-Regulation; Verapamil | 2002 |
L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the "slip-mode" phenomenon in cardiac myocytes?
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cats; Heart Failure; Heart Ventricles; Humans; In Vitro Techniques; Membrane Potentials; Myocardium; Nifedipine; Patch-Clamp Techniques; Phosphorylation; Sarcoplasmic Reticulum; Sodium; Sodium Channel Blockers; Sodium Channels; Species Specificity; Tetrodotoxin; Verapamil | 2002 |
Diminished inibitory action of ethanol on the contraction of gallbladder isolated from chronically ethanol-fed Guinea pigs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Body Weight; Calcium Channel Agonists; Dose-Response Relationship, Drug; Ethanol; Gallbladder; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Phorbol 12,13-Dibutyrate; Potassium Chloride; Verapamil | 2002 |
Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cesium; Chelating Agents; Diltiazem; Drug Resistance; Egtazic Acid; Electric Conductivity; Heart Ventricles; Isoproterenol; Kinetics; Magnesium; Membrane Potentials; Myocardium; Nifedipine; Patch-Clamp Techniques; Potassium; Receptors, Adrenergic, beta; Swine; Verapamil | 2002 |
Effect of serum withdrawal on the contribution of L-type calcium channels (CaV1.2) to intracellular Ca2+ responses and chemotaxis in cultured human vascular smooth muscle cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Actins; Amlodipine; Becaplermin; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Chemotaxis; Culture Media, Serum-Free; Humans; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Saphenous Vein; Verapamil | 2005 |
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil | 2005 |
Effects of L-type Ca2+ channel modulation on direct myocardial effects of diazepam and midazolam in adult rat ventricular myocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels, L-Type; Diazepam; Dose-Response Relationship, Drug; Heart Ventricles; Midazolam; Myocytes, Cardiac; Rats; Sarcoplasmic Reticulum; Verapamil | 2006 |
Expression of voltage-gated calcium channel subunit alpha1C in epidermal keratinocytes and effects of agonist and antagonists of the channel on skin barrier homeostasis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Epidermal Cells; Epidermis; Gene Expression; Homeostasis; Humans; Keratinocytes; Male; Mice; Mice, Hairless; Nifedipine; Permeability; RNA, Messenger; Verapamil | 2006 |
The uptake mechanism of gallium-67 into hepatocytes treated with carbon tetrachloride.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alanine Transaminase; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Carbon Tetrachloride; Cells, Cultured; Collagenases; Digitonin; Gallium Radioisotopes; Hepatocytes; Male; Rats; Rats, Wistar; Verapamil | 2007 |
Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Algorithms; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Felodipine; Ion Channel Gating; Male; Membrane Potentials; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Protein Binding; Rats; Rats, Wistar; Verapamil | 2007 |
Aortas isolated from sinoaortic-denervated rats exhibit rhythmic contractions that are regulated by pharmacologically distinct calcium sources.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amiloride; Animals; Aorta, Thoracic; Autonomic Denervation; Blood Pressure; Boron Compounds; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Chloride Channels; Dose-Response Relationship, Drug; Inositol 1,4,5-Trisphosphate Receptors; Male; Membrane Transport Modulators; Nitrobenzoates; Periodicity; Phenylephrine; Rats; Rats, Wistar; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium Channel Blockers; Sodium-Calcium Exchanger; Thapsigargin; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Verapamil | 2008 |
Elevation of cytosolic calcium level triggers calcium antagonist-induced gingival overgrowth.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Signaling; Cell Line; Cell Proliferation; Cytosol; Fibroblasts; Fluorescent Dyes; Fura-2; Gingiva; Humans; Verapamil | 2008 |
Verapamil inhibits L-type calcium channel mediated apoptosis in human colon cancer cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Apoptosis; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Culture Techniques; Cell Line, Tumor; Colonic Neoplasms; Humans; RNA, Messenger; Verapamil | 2008 |
Facilitation of acetylcholine secretion in mouse motor synapses caused by calcium release from depots upon activation of L-type calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; In Vitro Techniques; Mice; Motor Neurons; Peptides; Ryanodine; Ryanodine Receptor Calcium Release Channel; Synapses; Verapamil | 2009 |
Effect of calcium-regulating hormones and calcium channel modulators on glucose consumption by muscle and adipose tissues in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adipose Tissue; Animals; Calcitonin; Calcium Channel Agonists; Calcium Channel Blockers; Carbohydrate Metabolism; Glucose; In Vitro Techniques; Insulin; Male; Muscles; Parathyroid Hormone; Rats; Rats, Wistar; Verapamil | 2009 |
Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Amides; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Verapamil; Vitamin E | 2010 |
Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Proliferation; Dipeptides; Male; Muscle, Smooth, Vascular; Nifedipine; Nimodipine; Rats; Rats, Wistar; Verapamil | 2010 |
Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cell Differentiation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Induced Pluripotent Stem Cells; Mice; Myocytes, Cardiac; Verapamil | 2011 |
Identification of a sphingosine-sensitive Ca2+ channel in the plasma membrane of Leishmania mexicana.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Membrane; Ceramides; Humans; Leishmania mexicana; Molecular Sequence Data; Protein Structure, Tertiary; Sequence Analysis, Protein; Sphingosine; Verapamil | 2013 |
The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anthracenes; Benzylamines; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Conditioning, Classical; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fear; Hippocampus; In Vitro Techniques; Membrane Potentials; Mental Recall; Mice; Mice, Knockout; Norepinephrine; Patch-Clamp Techniques; Pyrazoles; Pyridines; Receptors, Adrenergic, beta-1; Signal Transduction; Verapamil | 2013 |
Anti-arrhythmic effect of verapamil is accompanied by preservation of cx43 protein in rat heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Connexin 43; Disease Models, Animal; Electrocardiography; Heart; Hemodynamics; Male; Myocardial Ischemia; Myocardium; Rats; Verapamil | 2013 |
Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cryoelectron Microscopy; Diltiazem; Ligands; Male; Models, Molecular; Nifedipine; Rabbits; Verapamil | 2019 |
Mechano-Pharmacological Testing of L-Type Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aorta; Biomechanical Phenomena; Biophysics; Calcium Channels, L-Type; Cell Survival; Humans; Muscle, Smooth, Vascular; Nifedipine; Stress, Mechanical; Vasoconstriction; Vasoconstrictor Agents; Verapamil | 2020 |
A mathematical model of hiPSC cardiomyocytes electromechanics.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Calcium Channel Agonists; Calcium Channel Blockers; Computer Simulation; Electrophysiological Phenomena; Humans; Induced Pluripotent Stem Cells; Models, Theoretical; Myocardial Contraction; Myocytes, Cardiac; Verapamil | 2021 |