Page last updated: 2024-08-25

bay h 2049 and quinazolines

bay h 2049 has been researched along with quinazolines in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's6 (28.57)18.2507
2000's6 (28.57)29.6817
2010's5 (23.81)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ames, MM; Mathiesen, DA; Reid, JM1
Bissery, MC; Corbett, TH; Luk, GD; Mucci-LoRusso, P; Plowman, J; Polin, L; Valeriote, F1
Ames, MM; Mathiesen, DA1
Atassi, G; Dykes, DJ; Harrison, SD; Kabbe, HJ; Narayanan, VL; Paull, KD; Plowman, J; Yoder, OC1
Atassi, G; Dumont, P; Kabbe, HJ; Yoder, O1
Barrows, LR; Chen, AY; LaVoie, EJ; Liu, LF; McQueen, CA; Meegalla, SK; Stevens, GJ; Yu, C1
McQueen, CA; Stevens, GJ1
Chen, AY; Cheng, CC; Chou, TC; Liu, LF; Luo, Y; Ren, YF; Yu, C1
LaVoie, EJ; McQueen, CA; Stevens, GJ1
McQueen, CA; Payton, M; Sim, E; Stevens, GJ1
Burkey, JL; McQueen, CA; Stevens, GJ1
Dzierzbicka, K; Kawula, J; Kołodziejczyk, AM1
Dzierzbicka, K; Myśliwski, A; Sewerynek, P; Trzonkowski, P1
Bociewicz, J; Dzierzbicka, K; Myśliwski, A; Szmit, E; Trzonkowski, P1
Arimondo, PB; Guillaumel, J; Léonce, S; Monneret, C; Pfeiffer, B; Pierré, A; Renard, P1
Agama, K; Holbeck, S; Pommier, Y; Rao, VA1
Dzierzbicka, K; Januchta, W; Skladanowski, A1
Anderson, LW; Chen, A; Collins, JM; Doroshow, JH; Gutierrez, ME; Klecker, RW; Kummar, S; Murgo, AJ1
Beller, M; Chen, J; Neumann, H; Wu, XF1
Altera, KP; Ames, MM; Buhrow, SA; Bunin, DI; Davis, M; Ji, J; Kinders, RJ; Lawrence, SM; Parman, T; Rausch, LL; Reid, JM; Samuelsson, SJ; Walden, C1
Cholewiński, G; Dzierzbicka, K; Januchta, W; Serocki, M; Skladanowski, A1

Reviews

2 review(s) available for bay h 2049 and quinazolines

ArticleYear
[Batracylin (BAT)--potential antineoplastic agent].
    Postepy biochemii, 2002, Volume: 48, Issue:1

    Topics: Acetylation; Animals; Antineoplastic Agents; Humans; Quinazolines

2002
Novel approaches in the synthesis of batracylin and its analogs: rebirth of an old player?
    Current medicinal chemistry, 2012, Volume: 19, Issue:26

    Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Quinazolines; Structure-Activity Relationship

2012

Trials

1 trial(s) available for bay h 2049 and quinazolines

ArticleYear
Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas.
    Cancer chemotherapy and pharmacology, 2013, Volume: 72, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Arylamine N-Acetyltransferase; Dose-Response Relationship, Drug; Female; Genotype; Humans; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Patient Selection; Pharmacogenetics; Quinazolines; Species Specificity; Young Adult

2013

Other Studies

18 other study(ies) available for bay h 2049 and quinazolines

ArticleYear
Differences in N-acetylation of the experimental antitumor agent batracylin in the mouse and the rat.
    Investigational new drugs, 1991, Volume: 9, Issue:3

    Topics: Acetylation; Administration, Oral; Animals; Antineoplastic Agents; Lethal Dose 50; Mice; Quinazolines; Rats; Species Specificity

1991
Activity of batracylin (NSC-320846) against solid tumors of mice.
    Investigational new drugs, 1989, Volume: 7, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cell Survival; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pancreatic Neoplasms; Quinazolines; Tumor Cells, Cultured

1989
High-performance liquid chromatographic assay and preclinical pharmacologic studies with the experimental antitumor agent batracylin.
    Journal of chromatography, 1989, Jul-21, Volume: 491, Issue:2

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Mice; Molecular Structure; Quinazolines

1989
Preclinical antitumor activity of batracylin (NSC 320846).
    Investigational new drugs, 1988, Volume: 6, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Tumor Cells, Cultured

1988
A new antitumour agent, batracylin, selected by a preclinical solid tumour model.
    Drugs under experimental and clinical research, 1988, Volume: 14, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Leukemia L1210; Leukemia P388; Melanoma, Experimental; Mice; Quinazolines

1988
Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.
    Journal of medicinal chemistry, 1994, Sep-30, Volume: 37, Issue:20

    Topics: Animals; Antineoplastic Agents; DNA; Humans; Indoles; Isoindoles; Leukemia; Liver; Pyridones; Pyrimidines; Quinazolines; Rats; Topoisomerase II Inhibitors; Tumor Cells, Cultured

1994
Species variation in the genotoxicity of batracylin.
    Toxicology and applied pharmacology, 1994, Volume: 126, Issue:1

    Topics: Acetylation; Animals; Cells, Cultured; DNA Repair; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutagenicity Tests; Mutagens; Quinazolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Salmonella typhimurium; Species Specificity

1994
A structure-activity relationship study of batracylin analogues.
    Pharmaceutical research, 1993, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; DNA Topoisomerases, Type II; DNA, Neoplasm; Humans; Hydrolysis; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured

1993
The role of acetylation in the mutagenicity of the antitumor agent, batracylin.
    Carcinogenesis, 1996, Volume: 17, Issue:1

    Topics: Acetylation; Acetyltransferases; Antineoplastic Agents; Humans; Mutagenicity Tests; Mutagens; Quinazolines

1996
N-acetylation of the heterocyclic amine batracylin by human liver.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:9

    Topics: 4-Aminobenzoic Acid; Acetylation; Adult; Aged; Antineoplastic Agents; Arylamine N-Acetyltransferase; Child, Preschool; Cloning, Molecular; Cytosol; DNA Primers; Female; Genotype; Humans; In Vitro Techniques; Kinetics; Liver; Male; Middle Aged; Quinazolines; Sulfamethazine

1999
Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A.
    Cell biology and toxicology, 2000, Volume: 16, Issue:1

    Topics: Acetylation; Acetyltransferases; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Hepatocytes; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutagens; Oxidoreductases, N-Demethylating; Quinazolines; Rats; Rats, Inbred F344; Species Specificity

2000
Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives.
    Journal of medicinal chemistry, 2003, Mar-13, Volume: 46, Issue:6

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Antineoplastic Agents; Cricetinae; Dipeptides; Drug Screening Assays, Antitumor; Humans; Quinazolines; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured

2003
Biological activity of conjugates of muramyl dipeptides with batracylin derivatives.
    International immunopharmacology, 2005, Volume: 5, Issue:2

    Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Inhibitory Concentration 50; Leukocytes; Middle Aged; Quinazolines; Structure-Activity Relationship

2005
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:3

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Indoles; Mice; Molecular Structure; Quinazolines

2006
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
    Cancer research, 2007, Oct-15, Volume: 67, Issue:20

    Topics: Biomarkers, Tumor; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; Enzyme Inhibitors; HCT116 Cells; Histones; HT29 Cells; Humans; Phosphorylation; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2007
Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes.
    Organic & biomolecular chemistry, 2014, Aug-21, Volume: 12, Issue:31

    Topics: Carbonates; Catalysis; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Brominated; Palladium; Quinazolines; Quinazolinones

2014
Characterization of Batracylin-induced Renal and Bladder Toxicity in Rats.
    Toxicologic pathology, 2015, Volume: 43, Issue:4

    Topics: Animals; Biomarkers, Tumor; Body Weight; Female; Glycosuria; Histones; Kidney Neoplasms; Male; Mesna; Phosphoproteins; Quinazolines; Random Allocation; Rats; Urinary Bladder Neoplasms

2015
Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation.
    European journal of medicinal chemistry, 2015, Dec-01, Volume: 106

    Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; DNA Damage; DNA Topoisomerases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Quinazolines; Structure-Activity Relationship; Topoisomerase Inhibitors; Tuftsin

2015