bay h 2049 has been researched along with quinazolines in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 6 (28.57) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ames, MM; Mathiesen, DA; Reid, JM | 1 |
| Bissery, MC; Corbett, TH; Luk, GD; Mucci-LoRusso, P; Plowman, J; Polin, L; Valeriote, F | 1 |
| Ames, MM; Mathiesen, DA | 1 |
| Atassi, G; Dykes, DJ; Harrison, SD; Kabbe, HJ; Narayanan, VL; Paull, KD; Plowman, J; Yoder, OC | 1 |
| Atassi, G; Dumont, P; Kabbe, HJ; Yoder, O | 1 |
| Barrows, LR; Chen, AY; LaVoie, EJ; Liu, LF; McQueen, CA; Meegalla, SK; Stevens, GJ; Yu, C | 1 |
| McQueen, CA; Stevens, GJ | 1 |
| Chen, AY; Cheng, CC; Chou, TC; Liu, LF; Luo, Y; Ren, YF; Yu, C | 1 |
| LaVoie, EJ; McQueen, CA; Stevens, GJ | 1 |
| McQueen, CA; Payton, M; Sim, E; Stevens, GJ | 1 |
| Burkey, JL; McQueen, CA; Stevens, GJ | 1 |
| Dzierzbicka, K; Kawula, J; Kołodziejczyk, AM | 1 |
| Dzierzbicka, K; Myśliwski, A; Sewerynek, P; Trzonkowski, P | 1 |
| Bociewicz, J; Dzierzbicka, K; Myśliwski, A; Szmit, E; Trzonkowski, P | 1 |
| Arimondo, PB; Guillaumel, J; Léonce, S; Monneret, C; Pfeiffer, B; Pierré, A; Renard, P | 1 |
| Agama, K; Holbeck, S; Pommier, Y; Rao, VA | 1 |
| Dzierzbicka, K; Januchta, W; Skladanowski, A | 1 |
| Anderson, LW; Chen, A; Collins, JM; Doroshow, JH; Gutierrez, ME; Klecker, RW; Kummar, S; Murgo, AJ | 1 |
| Beller, M; Chen, J; Neumann, H; Wu, XF | 1 |
| Altera, KP; Ames, MM; Buhrow, SA; Bunin, DI; Davis, M; Ji, J; Kinders, RJ; Lawrence, SM; Parman, T; Rausch, LL; Reid, JM; Samuelsson, SJ; Walden, C | 1 |
| Cholewiński, G; Dzierzbicka, K; Januchta, W; Serocki, M; Skladanowski, A | 1 |
2 review(s) available for bay h 2049 and quinazolines
| Article | Year |
|---|---|
[Batracylin (BAT)--potential antineoplastic agent].
Topics: Acetylation; Animals; Antineoplastic Agents; Humans; Quinazolines | 2002 |
Novel approaches in the synthesis of batracylin and its analogs: rebirth of an old player?
Topics: Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Quinazolines; Structure-Activity Relationship | 2012 |
1 trial(s) available for bay h 2049 and quinazolines
| Article | Year |
|---|---|
Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas.
Topics: Adult; Aged; Antineoplastic Agents; Arylamine N-Acetyltransferase; Dose-Response Relationship, Drug; Female; Genotype; Humans; Lymphoma; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Patient Selection; Pharmacogenetics; Quinazolines; Species Specificity; Young Adult | 2013 |
18 other study(ies) available for bay h 2049 and quinazolines
| Article | Year |
|---|---|
Differences in N-acetylation of the experimental antitumor agent batracylin in the mouse and the rat.
Topics: Acetylation; Administration, Oral; Animals; Antineoplastic Agents; Lethal Dose 50; Mice; Quinazolines; Rats; Species Specificity | 1991 |
Activity of batracylin (NSC-320846) against solid tumors of mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma, Intraductal, Noninfiltrating; Cell Survival; Cells, Cultured; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Pancreatic Neoplasms; Quinazolines; Tumor Cells, Cultured | 1989 |
High-performance liquid chromatographic assay and preclinical pharmacologic studies with the experimental antitumor agent batracylin.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Hydrogen-Ion Concentration; Injections, Intraperitoneal; Mice; Molecular Structure; Quinazolines | 1989 |
Preclinical antitumor activity of batracylin (NSC 320846).
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation, Preclinical; Injections, Intraperitoneal; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Quinazolines; Tumor Cells, Cultured | 1988 |
A new antitumour agent, batracylin, selected by a preclinical solid tumour model.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Leukemia L1210; Leukemia P388; Melanoma, Experimental; Mice; Quinazolines | 1988 |
Synthesis and pharmacological evaluation of isoindolo[1,2-b]quinazolinone and isoindolo[2,1-a]benzimidazole derivatives related to the antitumor agent batracylin.
Topics: Animals; Antineoplastic Agents; DNA; Humans; Indoles; Isoindoles; Leukemia; Liver; Pyridones; Pyrimidines; Quinazolines; Rats; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1994 |
Species variation in the genotoxicity of batracylin.
Topics: Acetylation; Animals; Cells, Cultured; DNA Repair; Liver; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutagenicity Tests; Mutagens; Quinazolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Salmonella typhimurium; Species Specificity | 1994 |
A structure-activity relationship study of batracylin analogues.
Topics: Antineoplastic Agents; DNA Topoisomerases, Type II; DNA, Neoplasm; Humans; Hydrolysis; Quinazolines; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
The role of acetylation in the mutagenicity of the antitumor agent, batracylin.
Topics: Acetylation; Acetyltransferases; Antineoplastic Agents; Humans; Mutagenicity Tests; Mutagens; Quinazolines | 1996 |
N-acetylation of the heterocyclic amine batracylin by human liver.
Topics: 4-Aminobenzoic Acid; Acetylation; Adult; Aged; Antineoplastic Agents; Arylamine N-Acetyltransferase; Child, Preschool; Cloning, Molecular; Cytosol; DNA Primers; Female; Genotype; Humans; In Vitro Techniques; Kinetics; Liver; Male; Middle Aged; Quinazolines; Sulfamethazine | 1999 |
Toxicity of the heterocyclic amine batracylin: investigation of rodent N-acetyltransferase activity and potential contribution of cytochrome P450 3A.
Topics: Acetylation; Acetyltransferases; Animals; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Glucuronosyltransferase; Hepatocytes; Male; Mice; Mice, Inbred A; Mice, Inbred C57BL; Mutagens; Oxidoreductases, N-Demethylating; Quinazolines; Rats; Rats, Inbred F344; Species Specificity | 2000 |
Synthesis and cytotoxic activity of conjugates of muramyl and normuramyl dipeptides with batracylin derivatives.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Antineoplastic Agents; Cricetinae; Dipeptides; Drug Screening Assays, Antitumor; Humans; Quinazolines; Solubility; Structure-Activity Relationship; Tumor Cells, Cultured | 2003 |
Biological activity of conjugates of muramyl dipeptides with batracylin derivatives.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adult; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Inhibitory Concentration 50; Leukocytes; Middle Aged; Quinazolines; Structure-Activity Relationship | 2005 |
Synthesis and biological activity of 6H-isoindolo[2,1-a]indol-6-ones, analogues of batracylin, and related compounds.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Heterocyclic Compounds; Humans; Indoles; Mice; Molecular Structure; Quinazolines | 2006 |
Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Topics: Biomarkers, Tumor; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; Enzyme Inhibitors; HCT116 Cells; Histones; HT29 Cells; Humans; Phosphorylation; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2007 |
Palladium-catalyzed synthesis of isoindoloquinazolinones via dicarbonylation of 1,2-dibromoarenes.
Topics: Carbonates; Catalysis; Gas Chromatography-Mass Spectrometry; Hydrocarbons, Brominated; Palladium; Quinazolines; Quinazolinones | 2014 |
Characterization of Batracylin-induced Renal and Bladder Toxicity in Rats.
Topics: Animals; Biomarkers, Tumor; Body Weight; Female; Glycosuria; Histones; Kidney Neoplasms; Male; Mesna; Phosphoproteins; Quinazolines; Random Allocation; Rats; Urinary Bladder Neoplasms | 2015 |
Synthesis of functionalized new conjugates of batracylin with tuftsin/retro-tuftsin derivatives and their biological evaluation.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Proliferation; Cell Survival; DNA Damage; DNA Topoisomerases; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Mice; Molecular Structure; NIH 3T3 Cells; Quinazolines; Structure-Activity Relationship; Topoisomerase Inhibitors; Tuftsin | 2015 |