bay-44-4400 and spirapril

bay-44-4400 has been researched along with spirapril* in 1 studies

Other Studies

1 other study(ies) available for bay-44-4400 and spirapril

ArticleYear
Perfusion calorimetry in the characterization of solvates forming isomorphic desolvates.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2011, Sep-18, Volume: 44, Issue:1-2

    In this study, the potential of perfusion calorimetry in the characterization of solvates forming isomorphic desolvates was investigated. Perfusion calorimetry was used to expose different hydrates forming isomorphic desolvates (emodepside hydrates II-IV, erythromycin A dihydrate and spirapril hydrochloride monohydrate) to stepwise increasing relative vapour pressures (RVP) of water and methanol, respectively, while measuring thermal activity. Furthermore, the suitability of perfusion calorimetry to distinguish the transformation of a desolvate into an isomorphic solvate from the adsorption of solvent molecules to crystal surfaces as well as from solvate formation that is accompanied by structural rearrangement was investigated. Changes in the samples were confirmed using FT-Raman and FT-IR spectroscopy. Perfusion calorimetry indicates the transformation of a desolvate into an isomorphic solvate by a substantial exothermic, peak-shaped heat flow curve at low RVP which reflects the rapid incorporation of solvent molecules by the desolvate to fill the structural voids in the lattice. In contrast, adsorption of solvent molecules to crystal surfaces is associated with distinctly smaller heat changes whereas solvate formation accompanied by structural changes is characterized by an elongated heat flow. Hence, perfusion calorimetry is a valuable tool in the characterization of solvates forming isomorphic desolvates which represents a new field of application for the method.

    Topics: Calorimetry; Chemistry, Pharmaceutical; Crystallization; Depsipeptides; Enalapril; Erythromycin; Isomerism; Methanol; Perfusion; Solubility; Solvents; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Surface Properties; Vapor Pressure; Water

2011