bay-41-8543 and pyrazolopyridine

bay-41-8543 has been researched along with pyrazolopyridine* in 1 studies

Other Studies

1 other study(ies) available for bay-41-8543 and pyrazolopyridine

Article	Year
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase. Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:6 The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543. Topics: Administration, Oral; Animals; Aorta; Blood Pressure; Crystallography, X-Ray; Dogs; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Lung; Molecular Structure; Morpholines; Nitric Oxide; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Wistar; Solubility; Vasodilation	2002

Article

Year

Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Bioorganic & medicinal chemistry, 2002, Volume: 10, Issue:6

The pyrazolopyridine stimulators of soluble guanylate cyclase BAY 41-2272 and 41-8543 were oxidised in rats and dogs at their 5-pyrimidinyl-cyclopropyl and -morpholino residue. These metabolites activate the soluble guanylate cyclase, induce vasoelaxation and thereby may contribute to the in vivo activity of BAY 41-2272 and BAY 41-8543.

Topics: Administration, Oral; Animals; Aorta; Blood Pressure; Crystallography, X-Ray; Dogs; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Lung; Molecular Structure; Morpholines; Nitric Oxide; Pyrazoles; Pyridines; Pyrimidines; Rats; Rats, Wistar; Solubility; Vasodilation

2002