bay-11-7082 and lobaric-acid

bay-11-7082 has been researched along with lobaric-acid* in 1 studies

Other Studies

1 other study(ies) available for bay-11-7082 and lobaric-acid

Article	Year
Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ. Bioorganic & medicinal chemistry, 2018, 12-01, Volume: 26, Issue:22 Herein we report the anti-inflammatory activity of lobaric acid and pseudodepsidones isolated from the nordic lichen Stereocaulon paschale. Lobaric acid (1) and three compounds (2, 7 and 9) were found to inhibit the NF-κB activation and the secretion of pro-inflammatory cytokines (IL-1β and TNF-α) in LPS-stimulated macrophages. Inhibition and docking simulation experiments provided evidence that lobaric acid and pseudodepsidones bind to PPAR-γ between helix H3 and the beta sheet, similarly to partial PPAR-γ agonists. These findings suggest that lobaric acid and pseudodepsidones reduce the expression of pro-inflammatory cytokines by blocking the NF-κB pathway via the activation of PPAR-γ. Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Depsides; Dose-Response Relationship, Drug; Humans; Lactones; Lichens; Lipopolysaccharides; Macrophages; Molecular Docking Simulation; Molecular Structure; NF-kappa B; PPAR gamma; Salicylates; Signal Transduction; Structure-Activity Relationship; U937 Cells	2018

Article

Year

Lobaric acid and pseudodepsidones inhibit NF-κB signaling pathway by activation of PPAR-γ.

Bioorganic & medicinal chemistry, 2018, 12-01, Volume: 26, Issue:22

Herein we report the anti-inflammatory activity of lobaric acid and pseudodepsidones isolated from the nordic lichen Stereocaulon paschale. Lobaric acid (1) and three compounds (2, 7 and 9) were found to inhibit the NF-κB activation and the secretion of pro-inflammatory cytokines (IL-1β and TNF-α) in LPS-stimulated macrophages. Inhibition and docking simulation experiments provided evidence that lobaric acid and pseudodepsidones bind to PPAR-γ between helix H3 and the beta sheet, similarly to partial PPAR-γ agonists. These findings suggest that lobaric acid and pseudodepsidones reduce the expression of pro-inflammatory cytokines by blocking the NF-κB pathway via the activation of PPAR-γ.

Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Depsides; Dose-Response Relationship, Drug; Humans; Lactones; Lichens; Lipopolysaccharides; Macrophages; Molecular Docking Simulation; Molecular Structure; NF-kappa B; PPAR gamma; Salicylates; Signal Transduction; Structure-Activity Relationship; U937 Cells

2018