barium-hydroxyapatite and strontium-titanium-oxide

To mimic the electrical properties of natural bone, controlled strontium substitution of both hydroxyapatite and ferroelectric barium titanate were achieved by mixing in the ratio 30:70 by weight. The composites were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy to investigate the phase composition and microstructure of the composites. Unpolarized and polarized strontium hydroxyapatite (SrHA)-barium strontium titanate (BST) composites with controlled degree of Sr substitution were examined, including 5SrHA-5BST (5% Sr substitution in both components) and 10SrHA-10BST composites. The 10SrHA-10BST composite showed a higher osteoblast activity, as observed from the cell viability studies performed using CCK-8 assay. The polarized composites showed promise against Staphylococcus aureus bacteria by minimizing the adhesion and growth of bacteria, as compared with their unpolarized counterparts. The polarized 10SrHA-10BST was found to be superior than all other composites. As a result, the approach of polarization of SrHA-BST composites has been found to be an effective bone substitute material in controlled enhancement of osteoblast growth with simultaneous reduction of bacterial infection.

Topics: Alkaline Phosphatase; Anti-Bacterial Agents; Barium Compounds; Cell Differentiation; Cell Line; Core Binding Factor Alpha 1 Subunit; Humans; Hydroxyapatites; Microbial Sensitivity Tests; Microbial Viability; Osteoblasts; Osteogenesis; Oxides; Spectroscopy, Fourier Transform Infrared; Staphylococcus aureus; Strontium; Titanium; X-Ray Diffraction