Page last updated: 2024-08-24

baicalin and geniposide

baicalin has been researched along with geniposide in 48 studies

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (22.92)29.6817
2010's33 (68.75)24.3611
2020's4 (8.33)2.80

Authors

AuthorsStudies
Chikhale, RV; Guneri, D; Morris, CJ; Waller, ZAE; Yuan, R1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Fujita, K; Hayashi, A; Kamataki, T; Mogami, A1
Bae, HS; Cho, KH; Kim, DH; Kim, JJ; Kim, YS; Moon, SK; Park, EK; Yim, JS1
Cheng, Y; Luo, G; Wang, Y; Xin, W; Yan, S1
Liang, Q; Liu, Q; Luo, G; Pan, Y; Pang, C; Ran, X; Wang, B1
Li, PT; Wang, LY; Wang, YY; Wang, Z; Zhang, ZJ1
Li, P; Li, PT; Sun, ZH; Wang, YY; Wang, Z; Zhang, WS; Zhang, XJ; Zhang, ZJ1
Lei, P; Li, XZ; Liu, S1
Gao, YH; Niu, FL; Pang, H; Shan, ZS; Wang, SR; Yuan, ZZ; Zhu, LQ2
Chen, Y; Han, FM; Li, LJ; Li, Y1
Ding, XY; Hao, F; Jiang, Y; Li, YR1
Fu, J; Guo, L; Pan, L; Zhu, H1
Jing, ZW; Li, M; Li, PT; Liu, J; Wang, LY; Wang, Z; Wu, HL; Yan, ZL; Zhang, ZJ; Zhou, CX; Zhou, J1
Chen, Y; Jing, Z; Liu, J; Lv, A; Meng, F; Wang, Y; Wang, Z; Yu, Y; Zhou, C1
Jo, HK; Jung, HJ; Kim, SG; Kim, YK; Poudel, A1
Li, L; Li, Y; Liu, R; Shan, L; Yuan, X; Zeng, H; Zhang, W1
Li, J; Meng, FY; Wang, CM; Wang, YY; Wang, Z; Wu, RG; Zhang, ZJ1
Ji, ZQ; Liu, H; Zhang, ZW1
Cheng, W; Li, P; Liu, J; Wang, Y; Zhang, J; Zhang, Z1
Chen, Y; Fang, H; Jing, Z; Liu, J; Lv, A; Meng, F; Wang, Y; Wang, Z; Yu, Y1
Chen, YY; Fang, H; Jing, ZW; Li, HX; Liu, J; Wang, YY; Wang, Z; Yu, YN; Zhang, YY1
Fang, X; Guan, S; Li, W; Liao, P; Liu, L; Wang, B2
Liu, JX; Ma, ZT; Yang, XW; Zhang, Y1
Lin, LC; Lu, CM; Tsai, TH1
Cheung, F; Feng, Y; Hong, M; Lao, L; Nagamatsu, T; Tan, HY; Wang, N1
Kim, JH; Kim, OS; Seo, CS; Shin, HK1
Dang, H; Li, B; Li, H; Li, K; Liu, J; Wang, H; Wang, P; Wang, Y; Wang, Z; Yu, Y; Zhang, Y1
Huang, CY; Huang, ZY; Liu, DD; Pan, BB; Ye, YL; Yu, YP; Zhang, Q1
Gao, X; Lu, Z; Peng, L; Qin, L; Song, Y; Wang, Q; Zhang, Q; Zhang, Z1
Dang, H; Guo, S; Li, B; Li, H; Liu, J; Wang, L; Wang, Y; Wang, Z; Wu, H; Yu, Y; Zhang, Y1
Chen, GR; Dou, DQ; Jing, J; Li, MY; Mackie, B; Wang, J; Zhang, G; Zhang, X1
Chen, Y; Kang, R; Li, B; Li, H; Liu, J; Wang, P; Wang, Z; Wu, H; Yu, Y; Zhang, X; Zhang, Y1
Kang, RX; Li, B; Liu, J; Wang, PQ; Wang, YY; Wang, Z; Wu, HL; Yu, YN; Zhang, XX; Zhang, YY1
Kong, L; Li, P; Liao, S; Lv, Y; Wang, J; Xu, D; Yang, M; Zhang, C; Zhang, Q1
Fu, S; Gao, X; Huang, Z; Liu, H; Liu, Y; Lu, F; Wang, M; Xie, Z; Yu, H; Zhang, Y; Zhang, Z; Zhao, H1
Guo, B; Liu, AM; Luo, M; Tan, Z1
Fu, X; Kong, L; Wang, J; Yang, M; Zhang, Q1
Li, B; Liu, J; Liu, Q; Ni, X; Wang, P; Wang, Y; Wang, Z; Yu, Y; Zhang, X; Zhang, Y1
Chen, G; Dou, D; Guo, S; Xu, Y; Zhang, M; Zhang, X1
Li, B; Liu, J; Liu, Q; Wang, PQ; Wang, Z; Xu, WJ; Yu, YN; Zhang, YY1
Kang, YG; Li, M; Shi, YH; Wang, B; Wang, C; Wu, J1
Cheng, HF; Huang, SS; Liu, PY; Tsai, CF; Wang, BC; Wang, DY; Yeh, CC1
Cai, Z; Ding, Y; Huang, T; Jin, M; Zhang, T1
Li, H; Li, M; Liu, J; Shi, Y; Wang, B; Wang, Y; Yang, H1
Chen, M; Chen, Y; Ma, H; Pan, H; Wu, Y; Zhang, S1

Other Studies

48 other study(ies) available for baicalin and geniposide

ArticleYear
Identification of sugar-containing natural products that interact with i-motif DNA.
    Bioorganic & medicinal chemistry letters, 2022, 10-01, Volume: 73

    Topics: Biological Products; DNA; G-Quadruplexes; Humans; Nucleic Acid Denaturation; Sugars

2022
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Establishment of Salmonella strain expressing catalytically active human UDP-glucuronosyltransferase 1A1 (UGT1A1).
    Life sciences, 2000, Apr-07, Volume: 66, Issue:20

    Topics: Animals; Bilirubin; Blotting, Western; Cell Fractionation; DNA Primers; DNA, Complementary; Enzyme Inhibitors; Escherichia coli; Flavonoids; Gene Expression; Glucuronates; Glucuronidase; Glucuronosyltransferase; Glycyrrhizic Acid; Humans; Iridoids; Microsomes, Liver; Plasmids; Polymerase Chain Reaction; Pyrans; RNA; Salmonella typhimurium; Transfection

2000
Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora.
    Biological & pharmaceutical bulletin, 2004, Volume: 27, Issue:10

    Topics: Adult; Chromatography, Thin Layer; Feces; Female; Flavanones; Flavonoids; Ginsenosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; In Vitro Techniques; Iridoid Glycosides; Iridoids; Male; Panax; Plant Extracts; Pyrans; Scutellaria baicalensis; Stereoisomerism

2004
[Simultaneous determination of five groups of components in qingkailing injection by high performance liquid chromatography with photo diode array detector and evaporative light scattering detector].
    Se pu = Chinese journal of chromatography, 2005, Volume: 23, Issue:5

    Topics: Adenosine; Caffeic Acids; Chlorogenic Acid; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Iridoids; Medicine, Chinese Traditional; Scattering, Radiation; Uridine

2005
Simultaneous determination of geniposide, baicalin, cholic acid and hyodeoxycholic acid in rat serum for the pharmacokinetic investigations by high performance liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Sep-14, Volume: 842, Issue:1

    Topics: Animals; Calibration; Cholic Acid; Chromatography, High Pressure Liquid; Deoxycholic Acid; Flavonoids; Iridoids; Male; Pyrans; Rats; Rats, Wistar; Reference Standards; Spectrometry, Mass, Electrospray Ionization

2006
[Pharmacological evaluation of baicalin and jasminoidin and their combination on focal cerebral ischemia-reperfusion injury].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:11

    Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; Drug Combinations; Flavonoids; Gardenia; Injections; Iridoids; Male; Neuroprotective Agents; Plants, Medicinal; Proto-Oncogene Proteins c-akt; Pyrans; Random Allocation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Scutellaria; Signal Transduction

2006
A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury.
    Brain research, 2006, Dec-06, Volume: 1123, Issue:1

    Topics: Analysis of Variance; Animals; Brain; Brain Ischemia; Brain-Derived Neurotrophic Factor; Caspase 3; Disease Models, Animal; Drug Combinations; Drug Therapy, Combination; Drugs, Chinese Herbal; Flavonoids; Iridoids; Male; Neuroprotective Agents; Nimodipine; Pyrans; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Statistics, Nonparametric

2006
[Determination of 3 kinds of components in huanglian jiedu decoction by HPLC under different UV wavelengths].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2006, Volume: 31, Issue:20

    Topics: Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Iridoids; Plants, Medicinal; Pyrans; Quality Control; Ultraviolet Rays

2006
[Protective action of effective components of Huanglian Jiedu decoction on hypoxia and reoxygenation injury in cultured rat cerebral microvascular endothelial cells].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007, Volume: 32, Issue:3

    Topics: Animals; Berberine; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Combinations; Drugs, Chinese Herbal; Endothelial Cells; Flavonoids; Iridoids; Male; Neuroprotective Agents; Oxygen; Plants, Medicinal; Pyrans; Rats; Rats, Sprague-Dawley

2007
[Simultaneous determination of geniposide, baicalin and berberine hydrochloride in Angong Niuhuang pill by RP-HPLC].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007, Volume: 32, Issue:14

    Topics: Berberine; Chromatography, High Pressure Liquid; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Iridoids; Materia Medica; Plants, Medicinal; Pyrans

2007
[Fast and simultaneous determination of four index components in Qingwei Huanglian tablets by RP-HPLC].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2007, Volume: 32, Issue:24

    Topics: Berberine; Chromatography, High Pressure Liquid; Coptis; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Gardenia; Glycyrrhiza; Glycyrrhizic Acid; Iridoids; Plants, Medicinal; Quality Control; Scutellaria baicalensis; Tablets

2007
[Effect of effective components of huanglian jiedu decoction on hypoxia, reoxygenation injury and the expression of VCAM in cultured rat cerebral microvascular endothelial cells].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:23

    Topics: Animals; Berberine; Cell Hypoxia; Cells, Cultured; Cerebrum; Drugs, Chinese Herbal; Endothelium, Vascular; Flavonoids; Gene Expression; Humans; Hypoxia; Iridoids; Male; Oxygen; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Vascular Cell Adhesion Molecule-1

2008
[Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010, Volume: 35, Issue:1

    Topics: Alkaloids; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavones; Flavonoids; Fractional Precipitation; Iridoids; Plants, Medicinal

2010
Comparison of the network structural characteristics of calcium signaling pathway in cerebral ischemia after intervention by different components of Chinese medicine.
    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2011, Volume: 31, Issue:3

    Topics: Animals; Brain Ischemia; Calcium Signaling; Drugs, Chinese Herbal; Flavonoids; Iridoids; Male; Mice; Nimodipine

2011
Variations in target gene expression and pathway profiles in the mouse hippocampus following treatment with different effective compounds for ischemia-reperfusion injury.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:8

    Topics: Animals; ATP-Binding Cassette Transporters; Capillary Electrochromatography; Cerebral Infarction; Cholic Acid; Drugs, Chinese Herbal; Flavonoids; Gene Expression; Hippocampus; Iridoids; Male; Mice; Microarray Analysis; Mitogen-Activated Protein Kinases; Real-Time Polymerase Chain Reaction; Reperfusion Injury; RNA; Signal Transduction

2012
Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas.
    Journal of natural medicines, 2013, Volume: 67, Issue:2

    Topics: Berberine; Drugs, Chinese Herbal; Flavanones; Flavonoids; Iridoids

2013
The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase.
    Journal of ethnopharmacology, 2012, Sep-28, Volume: 143, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Berberine; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Drugs, Chinese Herbal; Edema; Flavanones; Flavonoids; Iridoids; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; RNA, Messenger

2012
Synergism and rules from combination of Baicalin, Jasminoidin and Desoxycholic acid in refined Qing Kai Ling for treat ischemic stroke mice model.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Cluster Analysis; Computational Biology; Deoxycholic Acid; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Enzyme Inhibitors; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Iridoids; Ischemia; Male; Mice; Models, Statistical; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Principal Component Analysis; Stroke

2012
[Optimization of the extraction process for qingrejiedu oral liquid with synthesizing multiple guidelines grading method].
    Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2012, Volume: 35, Issue:8

    Topics: Administration, Oral; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavonoids; Gardenia; Iridoids; Plants, Medicinal; Quality Control; Reproducibility of Results; Scutellaria baicalensis; Technology, Pharmaceutical

2012
Ameliorative effects of a combination of baicalin, jasminoidin and cholic acid on ibotenic acid-induced dementia model in rats.
    PloS one, 2013, Volume: 8, Issue:2

    Topics: Alzheimer Disease; Animals; Cholic Acid; Dementia; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Flavonoids; Humans; Ibotenic Acid; Iridoids; Male; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Rats

2013
Hierarchical profiles of signaling pathways and networks reveal two complementary pharmacological mechanisms.
    CNS & neurological disorders drug targets, 2013, Volume: 12, Issue:6

    Topics: Animals; Brain Ischemia; Flavonoids; Gene Regulatory Networks; Iridoids; Male; Mice; Random Allocation; Signal Transduction; Transcriptome; Ursodeoxycholic Acid

2013
Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury.
    CNS neuroscience & therapeutics, 2014, Volume: 20, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Therapy, Combination; Drugs, Chinese Herbal; Flavonoids; Infarction, Middle Cerebral Artery; Iridoids; Male; Mice; Mice, Inbred Strains; Microarray Analysis; Molecular Sequence Data; Principal Component Analysis; Reperfusion Injury; Signal Transduction

2014
Oral administration of baicalin and geniposide induces regression of atherosclerosis via inhibiting dendritic cells in ApoE-knockout mice.
    International immunopharmacology, 2014, Volume: 20, Issue:1

    Topics: Administration, Oral; Animals; Aorta, Abdominal; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Dendritic Cells; Diet, High-Fat; Flavonoids; Iridoids; Lipids; Male; Mice, Inbred C57BL; Mice, Knockout

2014
Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction.
    Journal of Asian natural products research, 2014, Volume: 16, Issue:5

    Topics: Administration, Oral; Alkaloids; Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucosides; Iridoids; Molecular Structure; Rats; Rats, Sprague-Dawley

2014
Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE-/- mice.
    European journal of pharmacology, 2014, Oct-05, Volume: 740

    Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Flavonoids; Forkhead Transcription Factors; Interleukin-10; Iridoids; Lipids; Male; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Phytotherapy; Spleen; T-Lymphocytes, Regulatory; Transforming Growth Factor beta1

2014
Determination and pharmacokinetic study of gentiopicroside, geniposide, baicalin, and swertiamarin in Chinese herbal formulae after oral administration in rats by LC-MS/MS.
    Molecules (Basel, Switzerland), 2014, Dec-22, Volume: 19, Issue:12

    Topics: Administration, Oral; Animals; Area Under Curve; Chromatography, Gel; Drugs, Chinese Herbal; Flavonoids; Iridoid Glucosides; Iridoids; Limit of Detection; Male; Pyrones; Rats, Sprague-Dawley; Tandem Mass Spectrometry

2014
Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma.
    Journal of ethnopharmacology, 2015, Apr-22, Volume: 164

    Topics: Animals; Antineoplastic Agents; Berberine; Carcinoma, Hepatocellular; Cell Line, Tumor; Drugs, Chinese Herbal; Elongation Factor 2 Kinase; Female; Flavonoids; Humans; Iridoids; Liver Neoplasms; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Phytotherapy; Xenograft Model Antitumor Assays

2015
Simultaneous quantification and antiatherosclerosis effect of the traditional Korean medicine, Hwangryunhaedok-tang.
    BMC complementary and alternative medicine, 2015, Apr-08, Volume: 15

    Topics: Animals; Antioxidants; Atherosclerosis; Berberine; Berberine Alkaloids; Biphenyl Compounds; Cell Proliferation; Chromatography, High Pressure Liquid; Coptis; Drugs, Chinese Herbal; Flavonoids; Gardenia; Iridoids; Lipoproteins, LDL; Medicine, Korean Traditional; Muscle, Smooth, Vascular; Phellodendron; Phytotherapy; Picrates; Platelet-Derived Growth Factor; Rats; Regression Analysis; Scutellaria

2015
Variation of pathways and network profiles reveals the differential pharmacological mechanisms of each effective component to treat middle cerebral artery ischemia-reperfusion mice.
    Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:1

    Topics: Animals; Flavonoids; Gene Expression Profiling; Gene Regulatory Networks; Iridoids; Ischemia; Male; Metabolic Networks and Pathways; Mice; Microarray Analysis; Middle Cerebral Artery; Neuroprotective Agents; Reperfusion Injury; Ursodeoxycholic Acid

2016
[Screening of Active Fractions from Huanglian Jiedu Decoction against Primary Neuron Injury after Oxygen-Glucose Deprivation].
    Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2015, Volume: 35, Issue:8

    Topics: Animals; Berberine; Berberine Alkaloids; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucose; Iridoids; Models, Animal; Neurons; Oxygen; Rats; Reperfusion Injury

2015
Pharmacokinetic-Pharmacodynamic Modeling to Study the Antipyretic Effect of Qingkailing Injection on Pyrexia Model Rats.
    Molecules (Basel, Switzerland), 2016, Mar-07, Volume: 21, Issue:3

    Topics: Animals; Antipyretics; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fever; Flavonoids; Iridoids; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley

2016
Vertical and Horizontal Convergences of Targeting Pathways in Combination Therapy with Baicalin and Jasminoidin for Cerebral Ischemia.
    CNS & neurological disorders drug targets, 2016, Volume: 15, Issue:6

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Flavonoids; Gene Expression; Iridoids; Male; Mice; Microarray Analysis; Random Allocation; Reperfusion Injury

2016
The effective components of Huanglian Jiedu Decoction against sepsis evaluated by a lipid A-based affinity biosensor.
    Journal of ethnopharmacology, 2016, Jun-20, Volume: 186

    Topics: Animals; Berberine; Biosensing Techniques; Drugs, Chinese Herbal; Female; Flavonoids; Interleukin-6; Iridoids; Kidney; Lipid A; Lipopolysaccharides; Liver; Lung; Male; Mice, Inbred BALB C; Myocardium; Sepsis; Tumor Necrosis Factor-alpha

2016
Entropy-based divergent and convergent modular pattern reveals additive and synergistic anticerebral ischemia mechanisms.
    Experimental biology and medicine (Maywood, N.J.), 2016, Volume: 241, Issue:18

    Topics: Algorithms; Brain; Brain Ischemia; Drug Delivery Systems; Drug Synergism; Drug Therapy, Combination; Entropy; Flavonoids; Gene Ontology; Gene Regulatory Networks; Humans; Iridoids; Neuroprotective Agents; Transcriptome; Ursodeoxycholic Acid

2016
Quantitative Identification of Compound-Dependent On-Modules and Differential Allosteric Modules From Homologous Ischemic Networks.
    CPT: pharmacometrics & systems pharmacology, 2016, Volume: 5, Issue:10

    Topics: Animals; Brain Ischemia; Flavonoids; Gene Expression Profiling; Gene Regulatory Networks; Humans; Iridoids; Mice; Ursodeoxycholic Acid

2016
The components of Huang-Lian-Jie-Du-Decoction act synergistically to exert protective effects in a rat ischemic stroke model.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Animals; Berberine; Brain; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Flavonoids; Free Radical Scavengers; Infarction, Middle Cerebral Artery; Iridoids; Male; Metabolomics; Neuroprotective Agents; NF-E2-Related Factor 2; Oxidative Stress; Phytotherapy; Plants, Medicinal; Proton Magnetic Resonance Spectroscopy; Rats, Sprague-Dawley; Reperfusion Injury

2016
An integrated strategy by using target tissue metabolomics biomarkers as pharmacodynamic surrogate indices to screen antipyretic components of Qingkaikling injection.
    Scientific reports, 2017, 07-24, Volume: 7, Issue:1

    Topics: Administration, Intravenous; Animals; Antipyretics; Drugs, Chinese Herbal; Flavonoids; Hypothalamus; Iridoids; Male; Medicine, Chinese Traditional; Metabolomics; Rats; Rats, Sprague-Dawley

2017
[Screening of effective ingredients of Yinzhihuang injection against cholestasis and their mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2016, Volume: 41, Issue:6

    Topics: Alanine Transaminase; Animals; Chlorogenic Acid; Cholestasis; Cholesterol 7-alpha-Hydroxylase; Cytochrome P450 Family 8; Drugs, Chinese Herbal; Flavonoids; Humans; Iridoids; Liver; Male; Mice; Mice, Inbred ICR

2016
Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach.
    Oxidative medicine and cellular longevity, 2017, Volume: 2017

    Topics: Berberine; Brain Ischemia; Drugs, Chinese Herbal; Flavonoids; Humans; Iridoids; Medicine, Chinese Traditional; Metabolomics; Stroke

2017
Network-Wide Screen Identifies Variation of Novel Precise On-Module Targets Using Conformational Modudaoism.
    CPT: pharmacometrics & systems pharmacology, 2018, Volume: 7, Issue:1

    Topics: Allosteric Regulation; Brain Ischemia; Drug Discovery; Flavonoids; Gene Expression Profiling; Gene Regulatory Networks; Humans; Iridoids; Models, Genetic; Ursodeoxycholic Acid

2018
Evaluation of anti-sepsis activity by compounds with high affinity to lipid a from HuanglianJiedu decoction.
    Immunopharmacology and immunotoxicology, 2017, Volume: 39, Issue:6

    Topics: Animals; Berberine; Berberine Alkaloids; Cell Line; Drugs, Chinese Herbal; Flavonoids; Interleukin-6; Iridoids; Lipid A; Lipopolysaccharides; Mice; RAW 264.7 Cells; Sepsis; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2017
Pure mechanistic analysis of additive neuroprotective effects between baicalin and jasminoidin in ischemic stroke mice.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:6

    Topics: Animals; Apoptosis; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Flavonoids; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Hippocampus; Immunity, Innate; Infarction, Middle Cerebral Artery; Iridoids; Male; Mice; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Phenotype; RNA, Messenger; Signal Transduction; Systems Biology; Transcriptome

2018
Network pharmacology identification of mechanisms of cerebral ischemia injury amelioration by Baicalin and Geniposide.
    European journal of pharmacology, 2019, Sep-15, Volume: 859

    Topics: Animals; Arachidonate 5-Lipoxygenase; Brain Ischemia; Cell Line; Cell Polarity; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Flavonoids; Humans; Iridoids; Mice; Microglia; Molecular Targeted Therapy; Receptors, Leukotriene

2019
Simultaneous quantification of six indicator compounds in Wen-Qing-Yin by high-performance liquid chromatography-diode array detection.
    Journal of food and drug analysis, 2019, Volume: 27, Issue:3

    Topics: Berberine; Chromatography, High Pressure Liquid; Coumaric Acids; Drugs, Chinese Herbal; Flavonoids; Furaldehyde; Glucosides; Iridoids; Medicine, Chinese Traditional; Monoterpenes

2019
Enhancement effect of geniposide on solubility and intestinal absorption of baicalin.
    Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:5

    Topics: Animals; Drugs, Chinese Herbal; Duodenum; Flavonoids; Intestinal Absorption; Iridoids; Jejunum; Male; Rats; Rats, Sprague-Dawley; Solubility

2019
Baicalin and Geniposide Inhibit Polarization and Inflammatory Injury of OGD/R-Treated Microglia by Suppressing the 5-LOX/LTB4 Pathway.
    Neurochemical research, 2021, Volume: 46, Issue:7

    Topics: Amino Acid Sequence; Animals; Apoptosis; Arachidonate 5-Lipoxygenase; Cell Hypoxia; Cell Survival; Cells, Cultured; Epoxide Hydrolases; Flavonoids; Glucose; Humans; Inflammation; Iridoids; Mice; Microglia; Molecular Docking Simulation; Oxygen; Protein Binding; Signal Transduction

2021
Rapid Determination of Geniposide and Baicalin in Lanqin Oral Solution by Near-Infrared Spectroscopy with Chemometric Algorithms during Alcohol Precipitation.
    Molecules (Basel, Switzerland), 2022, Dec-20, Volume: 28, Issue:1

    Topics: Algorithms; Chemometrics; Ethanol; Least-Squares Analysis; Spectroscopy, Near-Infrared

2022