bafilomycin-a1 has been researched along with hygrolidin* in 3 studies
3 other study(ies) available for bafilomycin-a1 and hygrolidin
| Article | Year |
|---|---|
Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis.
A new bafilomycin-type macrolide, named hygrobafilomycin (6), was isolated by a bioassay-guided selection and fractionation from a terrestrial actinomycete, Streptomyces varsoviensis, along with three known derivatives, bafilomycin D (3), C1 (4) and C2 (5). The structure of hygrobafilomycin was fully established by MS and NMR analyses, revealing a hygrolidin-bafilomycin hybrid with an unusual monoalkylmaleic anhydride moiety. Hygrobafilomycin (6) shows strong antifungal, antiproliferative and cytotoxic activities. In a panel of 40 tumor cell lines, compound 6 shows high cytotoxic potency (mean IC(50)=5.3 n). Topics: Antibiotics, Antineoplastic; Antifungal Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Macrolides; Magnetic Resonance Spectroscopy; Maleates; Mass Spectrometry; Molecular Structure; Streptomyces | 2010 |
Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.
[reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide. Topics: Biological Products; Catalysis; Cyclization; Macrolides; Molecular Structure | 2006 |
Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.
Highly stereoselective syntheses of aldols 8a-c corresponding to the C(13)-C(25) segment of bafilomycin A(1) were developed by routes involving fragment assembly aldol reactions of chiral aldehyde 6a and the chiral methyl ketones 7. A remote chelation effect plays a critical role in determining the stereoselectivity of the key aldol coupling of 6a and the lithium enolate of 7b. The protecting group for C(23)-OH of the chiral aldehyde fragment also influences the selectivity of the lithium enolate aldol reaction. In contrast, the aldol reaction of 6a and the chlorotitanium enolates of 7a,c were much less sensitive to the nature of the C(15)-hydroxyl protecting group. Studies of the reactions of chiral aldehydes with Takai's (gamma-methoxyallyl)chromium reagent 40 are also described. The stereoselectivity of these reactions is also highly dependent on the protecting groups and stereochemistry of the chiral aldehyde substrates. Topics: Aldehydes; Anti-Bacterial Agents; Catalysis; Crystallography, X-Ray; Lithium Compounds; Macrolides; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism | 2002 |