bafilomycin-a1 and betulonic-acid

To develop antiviral therapeutics against human coronavirus (HCoV) infections, suitable coronavirus drug targets and corresponding lead molecules must be urgently identified. Here, we describe the discovery of a class of HCoV inhibitors acting on nsp15, a hexameric protein component of the viral replication-transcription complexes, endowed with immune evasion-associated endoribonuclease activity. Structure-activity relationship exploration of these 1,2,3-triazolo-fused betulonic acid derivatives yielded lead molecule

Topics: Antiviral Agents; Cell Line; Coronavirus 229E, Human; Dose-Response Relationship, Drug; Endoribonucleases; Enzyme Inhibitors; Humans; Microbial Sensitivity Tests; Models, Molecular; Oleanolic Acid; Viral Nonstructural Proteins; Virus Replication