bacoside-a has been researched along with andrographolide* in 1 studies
1 other study(ies) available for bacoside-a and andrographolide
| Article | Year |
|---|---|
Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study.
Andrographis paniculata, Bacopa monnieri and Centella asiatica are mentioned in Ayurveda for the management of neurodegenerative disorders. These plants and their phytomolecules, such as andrographolide, bacoside A and asiaticoside, were studied for their inhibition potential on pooled CYP450 as well as human CYP3A4, CYP2D6, CYP2C9 and CYP1A2 by CYP-CO complex assay and fluorogenic assay respectively followed by IC. CYP-CO complex assay indicated significantly less inhibition potential than standard inhibitor (P < 0.05 and above). A. paniculata showed highest inhibitory activity against CYP3A4 and CYP2D6 (IC. The findings suggested that selected food plants and bioactive compounds contributed negligible interaction potential with CYP isozymes and may not possess any harmful effect with regard to their therapeutic application. © 2016 Society of Chemical Industry. Topics: Andrographis; Bacopa; Centella; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Diterpenes; Humans; Medicine, Ayurvedic; Metals, Heavy; Neurodegenerative Diseases; Plant Extracts; Plants, Medicinal; Saponins; Spectrophotometry, Atomic; Triterpenes | 2017 |