baclofen and sodium oxybate

baclofen has been researched along with sodium oxybate in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (13.51)	18.7374
1990's	14 (18.92)	18.2507
2000's	33 (44.59)	29.6817
2010's	13 (17.57)	24.3611
2020's	4 (5.41)	2.80

Authors

Authors	Studies
Costentin, J; Marcais, H; Protais, P	1
Bernasconi, R; Bittiger, H; Lauber, J; Leonhardt, T; Marescaux, C; Martin, P; Reymann, N; Rubio, V; Vergnes, M	1
Smart, TG; Xie, X	1
Chmielewska, B; Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA	1
Björkman, S; Karlsson, JA; Koskinen, LO; Lewander, T; Zetterström, T	1
Garbutt, JC; van Kammen, DP	1
Lookingland, KJ; Moore, KE	1
DeManuele, F; Fisher, RH; Malyon, C; Norris, JW; Ridgley, B	1
Ostrovskaia, RU; Trofimov, SS	1
Chmielewska, B; Czuczwar, SJ; Kleinrok, Z; Turski, WA	1
Hedner, J; Hedner, T; Jonason, J; Lundberg, D	1
Henning, M; Persson, B	1
Banerjee, PK; Snead, OC	1
Engberg, G; Nissbrandt, H	2
Kryzhanovskiĭ, GN; Safonov, VA; Tarakanov, IA	1
Safonov, VA; Tarakanov, IA	1
Snead, OC	3
Antal, K; Crunelli, V; Emri, Z	1
Bernasconi, R; Bittiger, H; De Barry, J; Marescaux, C; Mathivet, P	1
Caffarra, P; Chiodera, P; Coiro, V; Saccani, A; Scaglioni, A; Volpi, R	1
Andersson, B; Engberg, G; Erhardt, S; Nissbrandt, H	1
Agabio, R; Colombo, G; Gessa, GL; Lobina, C; Reali, R	1
Hoffman, RS; Olmedo, R	1
Bettler, B; Kuhn, R; Lacampagne, A; Lorente, P; Malitschek, B; Pouzeratte, Y; Richards, S; Vassort, G	1
Banerjee, PK; Burnham, M; Hampson, D; Snead, OC	1
Agabio, R; Brunetti, G; Carai, MA; Colombo, G; Diaz, G; Gessa, GL; Littera, M; Lobina, C; Melis, S; Pani, M; Reali, R; Serra, S; Vacca, G	1
Bremner-Danielsen, M; Edlund, A; Ekstrand, AJ; Elg, S; Erickson, S; Johansson, T; Lehmann, A; Mattsson, JP; Quéva, C	1
Bettler, B; Bräuner-Osborne, H; Cryan, JF; Froestl, W; Kaupmann, K; Klebs, K; Mombereau, C; Mosbacher, J; Sansig, G; Schmutz, M; van der Putten, H; Waldmeier, P; Wellendorph, P	1
Biggio, G; Busonero, F; Follesa, P; Mameli, M; Mostallino, MC; Sanna, E; Spiga, S; Talani, G; Tranquilli, S	1
Carter, LP; Chen, W; Coop, A; France, CP; Koek, W; Unzeitig, AW; Wu, H	1
Eckermann, KA; France, CP; Koek, W	1
Madamba, SG; Roberto, M; Schweitzer, P; Siggins, GR	1
Carai, MA; Colombo, G; Froestl, W; Gessa, GL	1
Carter, LP; Chen, W; Coop, A; France, CP; Koek, W; Lamb, RJ; Wu, H	1
Carai, MA; Colombo, G; Gessa, GL; Lobina, C; Maccioni, P; Orrù, A	1
Carter, LP; Coop, A; France, CP; Koek, W; Wu, H	1
Carter, LP; Chen, W; Coop, A; France, CP; Koek, W	1
Bettler, B; Cryan, JF; Jacobson, LH; Kaupmann, K	1
Gergans, SR; Lyle, MA; Smith, MA	1
Carter, LP; France, CP; Koek, W	2
Coop, A; Koek, W; Mercer, SL	1
Boyer, SB; Creton, C; Cruz, HG; Labouèbe, G; Li, M; Lomazzi, M; Luján, R; Lüscher, C; Obata, K; Slesinger, PA; Watanabe, M; Wickman, K; Yanagawa, Y	1
France, CP; Khanal, M; Koek, W	1
Hagg, DS; LeTourneau, JL; Smith, SM	1
Ameisen, O	1
Baker, LE; Poling, A; Pynnonen, DM; Searcy, GD	1
France, CP; Koek, W	1
Hunt, GE; McGregor, IS; van Nieuwenhuijzen, PS	1
Antal, K; Emri, Z; Molnár, T; Nyitrai, G	1
McGregor, IS; van Nieuwenhuijzen, PS	1
Foreman, MM; Hanania, T; Malekiani, SA; Olivier, B; Paterson, NE	1
Guilleminault, C; Huang, YS	1
Coop, A; France, CP; Koek, W; Mercer, SL	1
Cheng, K; France, CP; Koek, W; Rice, KC	2
Bettler, B; Franken, P; Tafti, M; Vienne, J	1
Brown, MA; Guilleminault, C	1
Advani, T; Burke, TF; Cheng, K; Hensler, JG; Koek, W; Rice, KC	1
Constantinescu, I; Franken, P; Heinzer, R; Lecciso, G; Schwartz, S; Tafti, M; Vienne, J	1
Cheng, K; Koek, W; Rice, KC	1
Bassetti, CL; Gao, B; Hodor, A; Palchykova, S	1
De Jong, CA; Dijkstra, BA; Kamal, RM; Loonen, AJ	1
De Jong, CA; Dijkstra, BA; Kamal, RM; Schellekens, A	1
Dargan, PI; Floyd, CN; Wood, DM	1
Beurmanjer, H; de Jong, CAJ; Dijkstra, BAG; Kamal, RM; Schellekens, AFA	1
Kelly-Pieper, K; Kothare, SV; Morse, AM	1
Giil, LM; Sundal, EV	1
Chen, SY; Chu, FY; Tarng, DC; Yang, CY	1
Hiranita, T; Koek, W; McMahon, LR; Wilkerson, JL	1
Brett, J; Ezard, N; Freeman, G; Lindsey, R; Roberts, DM; Rodgers, C; Siefried, KJ	1

Reviews

5 review(s) available for baclofen and sodium oxybate

Article	Year
The interaction between GABA and dopamine: implications for schizophrenia. Schizophrenia bulletin, 1983, Volume: 9, Issue:3 Topics: Animals; Antipsychotic Agents; Baclofen; Brain Chemistry; Catalepsy; Dopamine; gamma-Aminobutyric Acid; Humans; Motor Activity; Neural Pathways; Neurons; Rats; Receptors, Dopamine; Rotation; Schizophrenia; Sodium Oxybate; Stereotyped Behavior; Valproic Acid	1983
Withdrawal syndromes. Emergency medicine clinics of North America, 2000, Volume: 18, Issue:2 Topics: Alcohol Withdrawal Delirium; Analgesics, Opioid; Baclofen; Emergencies; Emergency Treatment; Ethanol; Humans; Hypnotics and Sedatives; Muscle Relaxants, Central; Sodium Oxybate; Substance Withdrawal Syndrome	2000
Behavioral analyses of GHB: receptor mechanisms. Pharmacology & therapeutics, 2009, Volume: 121, Issue:1 Topics: Animals; Baclofen; Behavior, Animal; Discrimination Learning; GABA-B Receptor Agonists; Humans; Illicit Drugs; Narcolepsy; Receptors, GABA-A; Receptors, GABA-B; Reinforcement, Psychology; Sodium Oxybate	2009
A review of sodium oxybate and baclofen in the treatment of sleep disorders. Current pharmaceutical design, 2011, Volume: 17, Issue:15 Topics: Animals; Baclofen; GABA-B Receptor Agonists; Humans; Narcolepsy; Sleep; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Sodium Oxybate	2011
Baclofen in gamma-hydroxybutyrate withdrawal: patterns of use and online availability. European journal of clinical pharmacology, 2018, Volume: 74, Issue:3 Topics: Animals; Baclofen; Biomedical Research; Drug Trafficking; GABA-B Receptor Agonists; Humans; Internet; Pharmaceutical Services, Online; Practice Patterns, Physicians'; Prescription Drugs; Psychotropic Drugs; Social Media; Sodium Oxybate; Substance Withdrawal Syndrome; United Kingdom	2018

Trials

6 trial(s) available for baclofen and sodium oxybate

Article	Year
Different control mechanisms of growth hormone (GH) secretion between gamma-amino- and gamma-hydroxy-butyric acid: neuroendocrine evidence in Parkinson's disease. Psychoneuroendocrinology, 1997, Volume: 22, Issue:7 Topics: Aged; Baclofen; GABA Agents; GABA Agonists; gamma-Aminobutyric Acid; Growth Hormone; Humans; Male; Middle Aged; Parkinson Disease; Sodium Oxybate; Valproic Acid	1997
Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. Pediatric neurology, 2009, Volume: 41, Issue:1 Topics: Adolescent; Baclofen; Benzhydryl Compounds; Cataplexy; Central Nervous System Stimulants; Female; Follow-Up Studies; GABA Agonists; GABA-B Receptor Agonists; Humans; Male; Modafinil; Narcolepsy; Photoperiod; Polysomnography; Severity of Illness Index; Sleep; Sodium Oxybate; Time Factors	2009
Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory. Sleep, 2012, Aug-01, Volume: 35, Issue:8 Topics: Adult; Baclofen; Electroencephalography; GABA-B Receptor Agonists; Humans; Male; Memory; Polysomnography; Psychomotor Performance; Receptors, GABA-B; Sleep; Sleep Stages; Sodium Oxybate; Time Factors; Wakefulness; Young Adult	2012
Baclofen as relapse prevention in the treatment of gamma-hydroxybutyrate dependence: a case series. Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:3 Topics: Adult; Anesthetics; Baclofen; Drug Administration Schedule; Female; GABA-B Receptor Agonists; Humans; Male; Secondary Prevention; Sodium Oxybate; Substance-Related Disorders; Young Adult	2015
Baclofen as relapse prevention in the treatment of Gamma- Hydroxybutyrate (GHB) dependence: an open label study. BMC psychiatry, 2015, Apr-28, Volume: 15 Topics: Adult; Baclofen; Clinical Protocols; Craving; Female; GABA Agonists; Humans; Male; Quality of Life; Recurrence; Secondary Prevention; Sodium Oxybate; Substance-Related Disorders; Young Adult	2015
Baclofen to Prevent Relapse in Gamma-Hydroxybutyrate (GHB)-Dependent Patients: A Multicentre, Open-Label, Non-Randomized, Controlled Trial. CNS drugs, 2018, Volume: 32, Issue:5 Topics: Adult; Ambulatory Care; Baclofen; Female; GABA-B Receptor Agonists; Humans; Male; Secondary Prevention; Sodium Oxybate; Substance-Related Disorders; Treatment Outcome	2018

Other Studies

63 other study(ies) available for baclofen and sodium oxybate

Article	Year
Hypersensitivity of the climbing behaviour response to apomorphine induced by a short depression of dopaminergic neurone activity. Neuropharmacology, 1979, Volume: 18, Issue:11 Topics: 4-Butyrolactone; Animals; Apomorphine; Baclofen; Cycloheximide; Dopamine; Hydroxybutyrates; Male; Mice; Motor Activity; Neurons; Sodium Oxybate	1979
Experimental absence seizures: potential role of gamma-hydroxybutyric acid and GABAB receptors. Journal of neural transmission. Supplementum, 1992, Volume: 35 Topics: 4-Butyrolactone; Animals; Baclofen; Brain; Cyclic GMP; Disease Models, Animal; Epilepsy, Absence; GABA-A Receptor Antagonists; Male; Organophosphorus Compounds; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Reproducibility of Results; Sodium Oxybate; Valproic Acid	1992
gamma-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampal slices. European journal of pharmacology, 1992, Nov-17, Volume: 223, Issue:2-3 Topics: Animals; Baclofen; Bicuculline; Hippocampus; Membrane Potentials; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Sodium Oxybate; Synapses	1992
Modification of the anticonvulsant activity of 2-amino-5-phosphonovalerate by agents affecting different neurotransmitter systems. Neuropharmacology, 1985, Volume: 24, Issue:10 Topics: 2-Amino-5-phosphonovalerate; 4-Butyrolactone; Animals; Anticonvulsants; Atropine; Baclofen; Brain; Drug Interactions; Male; Mice; Muscimol; Neurotransmitter Agents; Sodium Oxybate; Synaptic Transmission; Valine	1985
Thermic and tremorogenic effects of thyroliberin (TRH) in reserpine-treated mice--the non-involvement of GABA-ergic mechanisms. The Journal of pharmacy and pharmacology, 1981, Volume: 33, Issue:9 Topics: Animals; Baclofen; Body Temperature Regulation; Dose-Response Relationship, Drug; Hydroxybutyrates; Male; Mice; Mice, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Reserpine; Sodium Oxybate; Thyrotropin-Releasing Hormone; Tremor	1981
Dopamine receptor-mediated regulation of incertohypothalamic dopaminergic neurons in the male rat. Brain research, 1984, Jun-25, Volume: 304, Issue:2 Topics: Animals; Baclofen; Diencephalon; Dopamine; Hypothalamus; Male; Mesencephalon; Neural Pathways; Norepinephrine; Rats; Receptors, Dopamine; Sodium Oxybate; Synaptic Transmission; Telencephalon	1984
Huntington's chorea. Canadian Medical Association journal, 1982, Mar-15, Volume: 126, Issue:6 Topics: Baclofen; Canada; gamma-Aminobutyric Acid; Health Facilities; Humans; Huntington Disease; Hydroxybutyrates; Sodium Oxybate	1982
[Nootropic properties of gamma-aminobutyric acid derivatives]. Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 97, Issue:2 Topics: Amnesia; Amnesia, Retrograde; Animals; Avoidance Learning; Baclofen; Butyrates; Conditioning, Classical; gamma-Aminobutyric Acid; Humans; Hydroxybutyrates; Hypoxia; Lithium; Mice; Organometallic Compounds; Piracetam; Sodium Oxybate	1984
Differential effects of baclofen, gamma-hydroxybutyric acid and muscimol on the protective action of phenobarbital and diphenylhydantoin against maximal electroshock-induced seizures in mice. Neuropharmacology, 1984, Volume: 23, Issue:2A Topics: Animals; Anticonvulsants; Baclofen; Drug Interactions; Electroshock; gamma-Aminobutyric Acid; Hydroxybutyrates; Injections, Intraventricular; Male; Mice; Muscimol; Oxazoles; Phenobarbital; Phenytoin; Sodium Oxybate	1984
GABA-ergic mechanisms in central respiratory control in the anesthetized rat. Naunyn-Schmiedeberg's archives of pharmacology, 1981, Volume: 317, Issue:4 Topics: Animals; Baclofen; Blood Gas Analysis; Blood Pressure; gamma-Aminobutyric Acid; Halothane; Heart Rate; Hydroxybutyrates; Injections, Intraventricular; Male; Muscimol; Rats; Rats, Inbred Strains; Respiration; Sodium Oxybate	1981
Effect of GABA analogues on blood pressure and central GABA metabolism in the rat. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:2 Topics: 3-Mercaptopropionic Acid; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Blood Pressure; Brain; Dopamine; gamma-Aminobutyric Acid; Heart Rate; Hydroxybutyrates; Male; Muscimol; Picrotoxin; Rats; Sodium Oxybate	1980
Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GH The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:3 Topics: Action Potentials; Animals; Baclofen; Epilepsy, Absence; Extracellular Space; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Organophosphorus Compounds; Potassium; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, GABA-B; Sodium Oxybate; Thalamic Nuclei	1995
gamma-Hydroxybutyric acid (GHBA) induces pacemaker activity and inhibition of substantia nigra dopamine neurons by activating GABAB-receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 348, Issue:5 Topics: Animals; Baclofen; Biological Clocks; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; GABA-B Receptor Antagonists; Injections, Intravenous; Male; Microelectrodes; Neurons; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sodium Oxybate; Substantia Nigra	1993
[The participation of the GABAergic system of the brain in shaping the breathing rhythm]. Fiziologicheskii zhurnal imeni I.M. Sechenova, 1993, Volume: 79, Issue:11 Topics: Animals; Apnea; Baclofen; Cats; Electromyography; Female; gamma-Aminobutyric Acid; Male; Medulla Oblongata; Periodicity; Receptors, GABA; Respiration; Respiratory Muscles; Sodium Oxybate	1993
[The effect of phenibut on formation of respiratory rhythm]. Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 119, Issue:6 Topics: Animals; Baclofen; Cats; Female; GABA Modulators; gamma-Aminobutyric Acid; Hemodynamics; Male; Receptors, GABA; Respiration; Sodium Oxybate	1995
Presynaptic GABAB-and gamma-hydroxybutyric acid-mediated mechanisms in generalized absence seizures. Neuropharmacology, 1996, Volume: 35, Issue:3 Topics: Animals; Baclofen; Calcium; Cerebral Cortex; GABA Modulators; GABA-B Receptor Agonists; Male; Rats; Rats, Sprague-Dawley; Rubidium; Sodium Oxybate; Synaptosomes	1996
Gamma-hydroxybutyric acid decreases thalamic sensory excitatory postsynaptic potentials by an action on presynaptic GABAB receptors. Neuroscience letters, 1996, Sep-27, Volume: 216, Issue:2 Topics: Adjuvants, Anesthesia; Animals; Anticonvulsants; Baclofen; Benzocycloheptenes; Bicuculline; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Geniculate Bodies; Male; Neurons, Afferent; Organophosphorus Compounds; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, GABA-B; Sodium Oxybate; Synaptic Transmission	1996
Relation of the [3H] gamma-hydroxybutyric acid (GHB) binding site to the gamma-aminobutyric acidB (GABAB) receptor in rat brain. Biochemical pharmacology, 1996, Oct-25, Volume: 52, Issue:8 Topics: Animals; Autoradiography; Baclofen; Benzocycloheptenes; Binding Sites; Brain; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guanosine Triphosphate; In Vitro Techniques; Male; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Seizures; Sodium Oxybate; Stereoisomerism	1996
The GABAB-receptor antagonist, CGP 35348, antagonises gamma-hydroxybutyrate- and baclofen-induced alterations in locomotor activity and forebrain dopamine levels in mice. Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:11 Topics: Animals; Baclofen; Depression, Chemical; Dopamine; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Male; Mice; Motor Activity; Organophosphorus Compounds; Prosencephalon; Sodium Oxybate	1996
Binding characteristics of gamma-hydroxybutyric acid as a weak but selective GABAB receptor agonist. European journal of pharmacology, 1997, Feb-19, Volume: 321, Issue:1 Topics: Animals; Anticonvulsants; Baclofen; Binding, Competitive; Brain Chemistry; Ethosuximide; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanylyl Imidodiphosphate; In Vitro Techniques; Male; Organophosphorus Compounds; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-B; Sodium Oxybate; Valproic Acid	1997
Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by gamma-hydroxybutyric acid (GHBA) are specifically induced by activation of GABA(B) receptors. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:6 Topics: Animals; Baclofen; Benzocycloheptenes; Dopamine; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; GABA Antagonists; GABA-B Receptor Antagonists; Iontophoresis; Male; Membrane Potentials; Morpholines; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, GABA-B; Sodium Oxybate; Substantia Nigra	1998
Involvement of GABA(A) and GABA(B) receptors in the mediation of discriminative stimulus effects of gamma-hydroxybutyric acid. Physiology & behavior, 1998, Jun-01, Volume: 64, Issue:3 Topics: Anesthetics, Intravenous; Animals; Baclofen; Diazepam; Discrimination, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Food; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, GABA-B; Reinforcement, Psychology; Sodium Oxybate	1998
gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America, 2000, Jul-18, Volume: 97, Issue:15 Topics: Adjuvants, Anesthesia; Animals; Baclofen; Cells, Cultured; Electrophysiology; GABA Agonists; GABA Antagonists; Gene Expression; Heart Ventricles; Mammals; Myocardium; Organophosphorus Compounds; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, GABA-B; RNA, Messenger; Sodium Oxybate	2000
Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4). The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-15, Volume: 20, Issue:16 Topics: Animals; Baclofen; Cerebral Cortex; Convulsants; Epilepsy, Absence; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Mice; Mice, Knockout; Neural Pathways; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Seizures; Sodium Oxybate; Thalamus	2000
Evidence for a G protein-coupled gamma-hydroxybutyric acid receptor. Journal of neurochemistry, 2000, Volume: 75, Issue:5 Topics: Adenylyl Cyclases; Animals; Baclofen; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; GABA Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Presynaptic; Sodium Oxybate; Subcellular Fractions	2000
Selective breeding of two rat lines differing in sensitivity to GHB and baclofen. Brain research, 2001, May-25, Volume: 902, Issue:1 Topics: Anesthesia Recovery Period; Anesthetics, Intravenous; Animals; Baclofen; Breeding; Drug Resistance; Female; GABA Agonists; GABA-B Receptor Agonists; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, GABA-B; Reflex; Sodium Oxybate	2001
Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice. British journal of pharmacology, 2003, Volume: 140, Issue:2 Topics: Animals; Baclofen; Behavior, Animal; Body Temperature Regulation; Brain; Cloning, Molecular; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Gene Expression Regulation; Genotype; Hypothermia; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Muscimol; Phenotype; Protein Subunits; Receptors, GABA-A; Receptors, GABA-B; RNA, Messenger; Sodium Oxybate	2003
Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European journal of neuroscience, 2003, Volume: 18, Issue:10 Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavior, Animal; Benzocycloheptenes; Binding, Competitive; Body Weight; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Electroencephalography; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phenols; Radioligand Assay; Receptors, GABA-B; Sodium Oxybate; Time Factors	2003
Changes in GABA(A) receptor gene expression associated with selective alterations in receptor function and pharmacology after ethanol withdrawal. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Dec-17, Volume: 23, Issue:37 Topics: Animals; Baclofen; Cells, Cultured; Chloride Channels; Diazepam; Electric Conductivity; Ethanol; GABA-A Receptor Agonists; Gene Expression Regulation; Hippocampus; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sodium Oxybate	2003
The Discriminative stimulus effects of gamma-hydroxybutyrate and related compounds in rats discriminating baclofen or diazepam: The role of GABA(B) and GABA(A) receptors. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:2 Topics: Adjuvants, Anesthesia; Animals; Baclofen; Diazepam; Discrimination Learning; GABA Agonists; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Sodium Oxybate	2004
Chronic 1,4-butanediol treatment in rats: cross-tolerance to gamma-hydroxybutyrate and (+/-)-baclofen. European journal of pharmacology, 2004, Jan-26, Volume: 484, Issue:2-3 Topics: Animals; Baclofen; Butylene Glycols; Dose-Response Relationship, Drug; Drug Tolerance; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Sodium Oxybate	2004
gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:1 Topics: Animals; Baclofen; Barium; GABA Agonists; Potassium; Protons; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sodium Oxybate; Synaptic Transmission	2004
In vivo effectiveness of CGP7930, a positive allosteric modulator of the GABAB receptor. European journal of pharmacology, 2004, Nov-19, Volume: 504, Issue:3 Topics: Animals; Baclofen; Drug Synergism; GABA Agonists; GABA-B Receptor Antagonists; Hypnotics and Sedatives; Male; Mice; Mice, Inbred DBA; Morpholines; Phenols; Receptors, GABA-B; Sodium Oxybate; Stereoisomerism	2004
Discriminative stimulus effects of gamma-hydroxybutyrate (GHB) in rats discriminating GHB from baclofen and diazepam. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1 Topics: 4-Butyrolactone; Anesthetics, Intravenous; Animals; Baclofen; Benzocycloheptenes; Benzylamines; Butylene Glycols; Diazepam; Discrimination, Psychological; Dithiothreitol; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Sodium Oxybate	2005
GHB-C rats: the control line of GHB-sensitive (GHB-S) and GHB-resistant (GHB-R) rats. Brain research. Brain research protocols, 2005, Volume: 15, Issue:1 Topics: Animals; Baclofen; Drug Resistance; Female; Hypnotics and Sedatives; Male; Muscle Relaxants, Central; Postural Balance; Rats; Rats, Inbred Strains; Sex Characteristics; Sleep; Sodium Oxybate	2005
Discriminative stimulus effects of flumazenil: perceptual masking by baclofen, and lack of substitution with gamma-hydroxybutyrate and its precursors 1,4-butanediol and gamma-butyrolactone. Behavioural pharmacology, 2006, Volume: 17, Issue:3 Topics: 4-Butyrolactone; Animals; Baclofen; Benzocycloheptenes; Butylene Glycols; Columbidae; Discrimination, Psychological; Dose-Response Relationship, Drug; Flumazenil; GABA Agonists; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Organophosphorus Compounds; Sodium Oxybate	2006
Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348. European journal of pharmacology, 2006, May-24, Volume: 538, Issue:1-3 Topics: Analysis of Variance; Animals; Baclofen; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Sodium Oxybate	2006
GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice. The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:3 Topics: Animals; Ataxia; Baclofen; Body Temperature; Darkness; Female; GABA Agonists; GABA-B Receptor Agonists; Hypothermia; Isomerism; Light; Male; Mice; Mice, Knockout; Motor Activity; Postural Balance; Receptors, GABA-B; Sensation Disorders; Sex Characteristics; Sodium Oxybate	2006
The motor-impairing effects of GABA(A) and GABA(B) agonists in gamma-hydroxybutyrate (GHB)-treated rats: cross-tolerance to baclofen but not flunitrazepam. European journal of pharmacology, 2006, Dec-15, Volume: 552, Issue:1-3 Topics: Adjuvants, Anesthesia; Analysis of Variance; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Flunitrazepam; GABA Agonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Male; Motor Activity; Rats; Rats, Long-Evans; Receptors, GABA-A; Receptors, GABA-B; Sodium Oxybate	2006
Lack of effects of GHB precursors GBL and 1,4-BD following i.c.v. administration in rats. The European journal of neuroscience, 2006, Volume: 24, Issue:9 Topics: 4-Butyrolactone; Anesthetics, Intravenous; Animals; Baclofen; Behavior, Animal; Blood-Brain Barrier; Brain; Butylene Glycols; GABA Agonists; Injections, Intraperitoneal; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Sodium Oxybate	2006
Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348. Psychopharmacology, 2007, Volume: 192, Issue:3 Topics: 4-Butyrolactone; Animals; Baclofen; Catalepsy; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Male; Mice; Mice, Inbred C57BL; Narcolepsy; Organophosphorus Compounds; Receptors, GABA-B; Sodium Oxybate; Substance-Related Disorders	2007
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nature neuroscience, 2007, Volume: 10, Issue:12 Topics: Animals; Animals, Newborn; Baclofen; Barium Compounds; Behavior, Animal; Chlorides; Dopamine; Dose-Response Relationship, Drug; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Glutamate Decarboxylase; Green Fluorescent Proteins; Homeodomain Proteins; In Vitro Techniques; Membrane Potentials; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; RGS Proteins; Sodium Oxybate; Transcription Factors; Ventral Tegmental Area	2007
Synergistic interactions between 'club drugs': gamma-hydroxybutyrate and phencyclidine enhance each other's discriminative stimulus effects. Behavioural pharmacology, 2007, Volume: 18, Issue:8 Topics: Animals; Baclofen; Discrimination Learning; Dose-Response Relationship, Drug; Drug Synergism; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Oxybate	2007
Baclofen and gamma-hydroxybutyrate withdrawal. Neurocritical care, 2008, Volume: 8, Issue:3 Topics: Adjuvants, Anesthesia; Baclofen; Benzodiazepines; Delirium; Epilepsy; Female; GABA Agonists; Humans; Middle Aged; Sodium Oxybate; Substance Withdrawal Syndrome; Tremor	2008
Are the effects of gamma-hydroxybutyrate (GHB) treatment partly physiological in alcohol dependence? The American journal of drug and alcohol abuse, 2008, Volume: 34, Issue:2 Topics: Alcoholism; Baclofen; GABA Agonists; GABA-B Receptor Agonists; Humans; Sodium Oxybate	2008
Differentiating the discriminative stimulus effects of gamma-hydroxybutyrate and ethanol in a three-choice drug discrimination procedure in rats. Pharmacology, biochemistry, and behavior, 2008, Volume: 89, Issue:4 Topics: 4-Butyrolactone; Animals; Baclofen; Benzocycloheptenes; Butylene Glycols; Discrimination, Psychological; Ethanol; Flunitrazepam; GABA Agonists; GABA Antagonists; GABA Modulators; Ketamine; Male; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Sodium Oxybate	2008
Cataleptic effects of gamma-hydroxybutyrate (GHB) and baclofen in mice: mediation by GABA(B) receptors, but differential enhancement by N-methyl-d-aspartate (NMDA) receptor antagonists. Psychopharmacology, 2008, Volume: 199, Issue:2 Topics: Anesthetics, Intravenous; Animals; Area Under Curve; Ataxia; Baclofen; Catalepsy; Data Interpretation, Statistical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Ketamine; Male; Mice; Mice, Inbred C57BL; Muscle Relaxants, Central; Phencyclidine; Receptors, GABA-B; Receptors, N-Methyl-D-Aspartate; Sodium Oxybate	2008
The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: comparison with baclofen. Neuroscience, 2009, Jan-23, Volume: 158, Issue:2 Topics: Anesthetics, Intravenous; Animals; Area Under Curve; Baclofen; Brain; Cell Count; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression Regulation; Male; Motor Activity; Oncogene Proteins v-fos; Rats; Rats, Wistar; Sodium Oxybate	2009
gamma-Hydroxybutyrate (GHB) induces GABA(B) receptor independent intracellular Ca2+ transients in astrocytes, but has no effect on GHB or GABA(B) receptors of medium spiny neurons in the nucleus accumbens. Neuroscience, 2009, Aug-18, Volume: 162, Issue:2 Topics: Animals; Astrocytes; Baclofen; Calcium; Dendritic Spines; Excitatory Postsynaptic Potentials; GABA-B Receptor Agonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred BALB C; Neurons; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, GABA-B; Sodium Oxybate	2009
Sedative and hypothermic effects of gamma-hydroxybutyrate (GHB) in rats alone and in combination with other drugs: assessment using biotelemetry. Drug and alcohol dependence, 2009, Aug-01, Volume: 103, Issue:3 Topics: Animals; Baclofen; Benzazepines; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Flumazenil; Hypothermia; Illicit Drugs; Male; Methamphetamine; Morpholines; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Naltrexone; Rats; Rats, Wistar; Ritanserin; Sodium Oxybate; Telemetry	2009
Pharmacological characterization of harmaline-induced tremor activity in mice. European journal of pharmacology, 2009, Aug-15, Volume: 616, Issue:1-3 Topics: Affect; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Benzazepines; Carbolines; Chlordiazepoxide; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamates; Harmaline; Lithium Chloride; Male; Mice; Mice, Inbred ICR; Muscimol; Neurotransmitter Agents; Piperazines; Propranolol; Raclopride; Receptors, Glutamate; Sodium Oxybate; Tremor	2009
Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348). The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3 Topics: 4-Butyrolactone; Anesthetics, Intravenous; Animals; Baclofen; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Injections, Intramuscular; Kinetics; Organophosphorus Compounds; Sodium Oxybate	2009
GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo. The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1 Topics: Animals; Baclofen; Benzofurans; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Hypothermia; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organophosphorus Compounds; Phenols; Sodium Oxybate	2010
Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Oct-20, Volume: 30, Issue:42 Topics: Anesthetics, Intravenous; Animals; Baclofen; Behavior, Animal; Delta Rhythm; Electrodes, Implanted; Electroencephalography; Electromyography; Epilepsy; GABA Agonists; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Receptors, GABA-B; Sleep; Sleep Deprivation; Sleep, REM; Sodium Oxybate; Theta Rhythm	2010
GABAB receptor-positive modulators: brain region-dependent effects. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1 Topics: Animals; Autoradiography; Baclofen; Benzofurans; Brain; Brain Chemistry; GABA Agonists; GABA Modulators; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; In Vitro Techniques; Mice; Mice, Inbred C57BL; Phenols; Receptors, GABA-B; Sodium Oxybate	2012
Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons. The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:2 Topics: Animals; Baclofen; Benzofurans; Columbidae; Conditioning, Operant; Discrimination, Psychological; GABA Antagonists; GABA-B Receptor Agonists; Phenols; Phosphinic Acids; Receptors, GABA-B; Sodium Oxybate	2012
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3 Topics: Animals; Baclofen; Benzodiazepines; Benzofurans; Cocaine; Columbidae; Diazepam; Discrimination, Psychological; Ethanol; GABA-B Receptor Agonists; Illicit Drugs; Nicotine; Organophosphorus Compounds; Phenols; Sodium Oxybate	2013
Baclofen and gamma-hydroxybutyrate differentially altered behavior, EEG activity and sleep in rats. Neuroscience, 2015, Jan-22, Volume: 284 Topics: Adjuvants, Anesthesia; Analysis of Variance; Animals; Baclofen; Behavior, Animal; Brain Waves; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; GABA-B Receptor Agonists; Male; Rats; Rats, Sprague-Dawley; Sleep; Sodium Oxybate	2015
Management of Excessive Daytime Sleepiness in Narcolepsy With Baclofen. Pediatric neurology, 2019, Volume: 93 Topics: Adolescent; Baclofen; Central Nervous System Depressants; Female; GABA-B Receptor Agonists; Humans; Male; Narcolepsy; Sodium Oxybate; Treatment Outcome	2019
Severe delirium after GHB abuse. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2020, 02-04, Volume: 140, Issue:2 Topics: Baclofen; Delirium; Female; Humans; Propofol; Sodium Oxybate; Substance Withdrawal Syndrome	2020
Flumazenil partially reverses gamma-hydroxybutyrate (GHB)-induced coma: a case report. The American journal of drug and alcohol abuse, 2022, 09-03, Volume: 48, Issue:5 Topics: Baclofen; Coma; Flumazenil; Humans; Sodium Oxybate	2022
The discriminative stimulus effects of baclofen and gamma hydroxybutyrate in C57BL/6J mice. Behavioural pharmacology, 2022, 09-01, Volume: 33, Issue:6 Topics: Animals; Baclofen; GABA Agonists; Male; Mice; Mice, Inbred C57BL; Midazolam; Morphine Derivatives; Receptors, GABA-B; Sodium Oxybate	2022
Inpatient GHB withdrawal management in an inner-city hospital in Sydney, Australia: a retrospective medical record review. Psychopharmacology, 2023, Volume: 240, Issue:1 Topics: 4-Butyrolactone; Baclofen; Delirium; Diazepam; Female; Hospitals, Urban; Humans; Inpatients; Male; Medical Records; Prospective Studies; Retrospective Studies; Sodium Oxybate; Substance Withdrawal Syndrome	2023