baclofen has been researched along with morphine in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (26.85) | 18.7374 |
| 1990's | 38 (25.50) | 18.2507 |
| 2000's | 49 (32.89) | 29.6817 |
| 2010's | 19 (12.75) | 24.3611 |
| 2020's | 3 (2.01) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Baert, B; Beetens, J; Bodé, S; De Spiegeleer, B; Deconinck, E; Lambert, J; Slegers, G; Slodicka, M; Stoppie, P; Van Gele, M; Vander Heyden, Y | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bissada, NK; Finkbeiner, AE; Welch, LT | 1 |
| Kameyama, T; Nabeshima, T; Ukai, M | 1 |
| Levy, RA; Proudfit, HK | 3 |
| Kuki, M; Ozaki, M; Yamamoto, H | 1 |
| Cutting, DA; Jordan, CC | 1 |
| DeWitte, P; Kalivas, PW; Klitenick, MA | 1 |
| Ashizawa, T; Misawa, M; Nabeshima, A; Nagase, H; Narita, M; Ozawa, H; Saito, T; Suzuki, T; Takahata, N | 1 |
| Bartolini, A; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Giridhar, J; Isom, GE; Peoples, RW | 1 |
| Bastide, R; Lazorthes, Y; Sallerin-Caute, B; Verdie, JC | 1 |
| Harris, V; Vasko, MR | 1 |
| Alberch, J; Arenas, E; Marsal, J | 1 |
| Cremades, A; Del Rio-Garcia, J | 1 |
| Jakovlev, V; Nickel, B; Szelenyi, I | 1 |
| Robertson, G; Sawynok, J | 1 |
| Hwang, AS; Wilcox, GL | 1 |
| Aley, KO; Kulkarni, SK | 1 |
| Frost, F; Nanninga, JB; Penn, R | 1 |
| Kontani, H; Nakagawa, M; Sakai, T | 1 |
| Zieglgänsberger, W | 1 |
| Andreev, BV; Ignatov, IuD | 1 |
| Ciuffi, M; Franchi-Micheli, S; Gentilini, G; Gori, AM; Luzzi, S; Zilletti, L | 1 |
| Penn, RD | 1 |
| Drenger, B; Magora, F; Shazar, N | 1 |
| Abelli, L; Conte, B; Giuliani, S; Maggi, CA; Meli, A; Somma, V | 1 |
| Ho, IK; Sivam, SP | 2 |
| Dickson, C; Sawynok, J | 1 |
| Kharin, NA; Komissarov, IV; Serdiuk, SE | 1 |
| Rea, GL; Siegfried, J | 1 |
| Djavdan, M; Zarrindast, MR | 1 |
| Panerai, AE | 1 |
| Contreras, E; Rifo, J; Tamayo, L | 1 |
| Hoehn, K; Reid, A; Sawynok, J | 1 |
| Kruszewska, A | 1 |
| Kasdon, DL | 1 |
| Pelley, KA; Vaught, JL | 1 |
| Enna, SJ; Zorn, SH | 1 |
| Alexandre, F; Angelini, L; Benezech, J; Broggi, G; Claverie, P; Deonna, T; Frerebeau, P; Lazorthes, Y; Siegfried, J; Verdie, JC | 1 |
| DeFeudis, FV | 1 |
| Reddy, SV; Yaksh, TL | 1 |
| Foong, FW; Satoh, M | 2 |
| Murakoshi, T; Otsuka, M; Tamai, S; Yanagisawa, M | 1 |
| Moochhala, SM; Pillay, DJ; Sawynok, J | 1 |
| Buescher, HH; Hill, RC; Maurer, R; Roemer, D | 1 |
| Kaneto, H; Rahman, AF; Takahashi, M | 1 |
| Ali, A; Kroin, JS; Penn, RD; York, M | 1 |
| Chodakiewitz, JW | 1 |
| Sadjak, A; Wintersteiger, R | 1 |
| Bingel, U; Kloke, M; Seeber, S | 1 |
| Birch, PJ; Elliott, PJ; Harrison, SM; Smith, GD; Wiseman, J | 1 |
| Brodkey, JA; Feler, CA | 1 |
| Ault, B; Hildebrand, LM | 1 |
| Gear, RW; Gordon, NC; Heller, PH; Levine, JD; Miaskowski, C; Paul, S | 1 |
| Baeyens, JM; Barrios, M; Ocaña, M | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 2 |
| Choi, SR; Choi, YS; Kim, YH; Song, DK; Suh, HW | 1 |
| Ishibashi, Y; Nakagawa, Y; Shimada, M; Suzuki, T; Takashima, T; Tsuji, M; Yoshii, T | 1 |
| Levin, AB; Sperling, KB | 1 |
| Chieng, B; Christie, MD | 1 |
| Ichida, T; Kuriyama, K | 1 |
| Kelly, MJ; Lagrange, AH; Rønnekleiv, OK; Wagner, EJ; Zhang, G | 1 |
| Choi, YS; Kim, YH; Song, DK; Suh, HW; Tseng, LF; Yoo, JS | 1 |
| Bartolini, A; Capaccioli, S; Galeotti, N; Ghelardini, C; Papucci, L; Quattrone, A | 1 |
| Grond, S; Radbruch, L; Zech, D | 1 |
| Guilbaud, G; Idänpään-Heikkilä, JJ | 1 |
| Hosoki, K; Kawashima, K; Shimizu, I | 1 |
| Parvini, S; Pirali, M; Rezayat, M; Tabarrai, E; Zarrindast, MR | 1 |
| Capasso, A | 1 |
| Eastwood, C; Fox, A; Gentry, C; Manning, D; Urban, L | 1 |
| Hara, K; Kirihara, Y; Kosaka, Y; Saito, Y; Sakura, S; Yamada, Y | 1 |
| Hao, JX; Wiesenfeld-Hallin, Z; Xu, IS; Xu, XJ | 1 |
| Chung, KM; Huh, SO; Kim, YH; Song, DK; Suh, HW | 1 |
| Gerayli, A; Ridgeway, B; Wallace, M | 1 |
| Bertorelli, R; Citterio, F; Corradini, L; Smith, RD | 1 |
| Sahebgharani, M; Valizadeh, S; Zarrindast, M | 1 |
| Balerio, GN; Diaz, SL; Kemmling, AK; Rubio, MC | 1 |
| Jang, CG; Kim, HS; Lee, MK; Oh, KW; Oh, SK; Seong, YH; Woo, SH; Yun, JS | 1 |
| Hao, JX; Sollevi, A; von Heijne, M; Xu, XJ | 1 |
| Mahmoudi, M; Zarrindast, MR | 2 |
| Fukudome, EY; Kaplan, GB; Leite-Morris, KA | 1 |
| Becker, R; Bertalanffy, H; Gatscher, S; Uhle, E | 1 |
| Balerio, GN; Kemmling, AK; Rubio, MC | 1 |
| Anderson, KJ; Brown, K; Farmer, JP | 1 |
| Adriaensen, H; Colpaert, FC; Deseure, K; Koek, W | 1 |
| Dickerman, RD; Schneider, SJ; Stevens, QE | 1 |
| Collu, M; Fadda, P; Fratta, W; Fresu, A; Scherma, M | 1 |
| Martin, TW; Mayhew, JF | 1 |
| Mizuo, K; Narita, M; Shibasaki, M; Suzuki, T | 1 |
| Carey, RJ; Joshi, M; Kaplan, GB; Leite-Morris, KA; Shoeb, MH | 1 |
| Mani, RM; Oo, T; Soni, BM; Vaidyanathan, S | 1 |
| Turner, MS | 1 |
| Fukudome, EY; Kaplan, GB; Leite-Morris, KA; Shoeb, MH | 1 |
| Gregori, P; Guevara, D; Portell, E; Vallés, M; Vidal, J | 1 |
| Carai, MA; Colombo, G; Gessa, GL; Serra, S; Vacca, G | 1 |
| Favre, J; Galarza, M; Janszen, M; Taha, A; Taha, J | 1 |
| Balerio, GN; Bonavita, CD; Diaz, SL; Kemmling, AK; Rubio, MC | 1 |
| Akizuki, A; Shimoyama, M; Shimoyama, N; Takahashi, H | 1 |
| De Vry, J; Jentzsch, KR | 1 |
| Bagley, EE; Chieng, BC; Christie, MJ; Connor, M | 1 |
| Imai, S; Khotib, J; Nakamura, A; Narita, M; Nurrochmad, A; Ozaki, M; Shibasaki, M; Suzuki, T; Yajima, Y | 1 |
| Amiri, YA; Ghoshooni, H; Haeri-Rohani, A; Pourmotabbed, A; Sahraei, H; Salimi, SH; Sepehri, H; Zahirodin, A; Zardooz, H | 1 |
| Hefferan, MP; Kakinohana, O; Marsala, J; Marsala, M; Nakamura, S; Tomori, Z | 1 |
| Antonelli, MC; Balerio, GN; Barros, VG; Diaz, SL; Rubio, MC | 1 |
| Fossum, EN; Ingram, SL; Morgan, MM | 1 |
| Ghadimi, M; Ramezani-Tehrani, B; Sahebgharani, M; Zarrindast, MR | 1 |
| Chiu, K; Evans, CJ; Kieffer, BL; Maidment, NT; Walwyn, WM; Wei, W; Xie, CW | 1 |
| Holstein, SE; Phillips, TJ | 1 |
| Bartoletti, M; Gaiardi, M; Ricci, F | 1 |
| Bundock, E; Graham, WA; Nero, C; Nesathurai, S; Protopapas, MG; Westmoreland, S | 1 |
| Poopatana, CA; Sadiq, SA | 1 |
| Taira, T | 1 |
| Dehpour, AR; Karimian, SM; Mirzaii-Dizgah, I; Riahi, E; Roodsari, HR; Sadeghipour, HR | 1 |
| Esfandiari, B; Etemadi, L; Ghoshooni, H; Noroozzadeh, A; Pourmotabbed, A; Rostami, P; Sahraei, H; Salimi, SH; Shams, J; Zarrindast, MR | 1 |
| Heinmiller, A; Ting-A-Kee, R; van der Kooy, D; Vargas-Perez, H; Yeh, A | 1 |
| Choi, KH; Choi, SH; Hwang, M; Kim, JA; Lee, BH; Shim, I; Yang, CH; Yoon, SS | 1 |
| Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Sim, YB; Suh, HW | 1 |
| Carey, RJ; Heinrichs, SC; Kaplan, GB; Leite-Morris, KA | 1 |
| Abram, S; Gerstein, N; Sanders, JC; Torgeson, E | 1 |
| Deer, T; Rauck, RL; Wallace, MS | 1 |
| Bourova, L; Dlouha, K; Kagan, D; Novotny, J; Svoboda, P; Vosahlikova, M | 1 |
| Javier, N; Tomas, M | 1 |
| Bartoletti, M; Colantoni, A; De Luca, V; Gaiardi, M | 1 |
| Saulino, M | 1 |
| Fu, Z; Huang, H; Xiao, Y; Yang, H; Zhao, G | 1 |
| Artola, A; Dallel, R; Jacquot, F; Melin, C | 1 |
| Balerio, GN; Induni, AS; Pedrón, VT; Taravini, IR | 1 |
| Bailey, CP; Dewey, WL; Gabra, BH; Henderson, G; Hull, LC | 1 |
| Meng, S; Qi, X; Quan, W; Su, Z; Yang, S | 1 |
| Cui, CL; Ge, FF; Li, YJ; Ping, XJ; Qi, C; Shen, F; Sun, LL; Sun, XW; Xing, GG | 1 |
| Balerio, GN; Pedrón, VT; Varani, AP | 1 |
| Mohs, AJ; Peace, MR; Poklis, A; Poklis, JL; Wolf, CE | 1 |
| Bundrick, JB; Feely, MA; Litin, SC | 1 |
| Alkhatib, O; Andersson, DA; Bevan, S; Gentry, C; Quallo, T | 1 |
| Ashabi, G; Hoseini, M; Karimiyan, SM; Mehrabadi, S; Moradbeygi, K | 1 |
| Doi, M; Irifune, M; Kanematsu, T; Morioka, N; Mukai, A; Nakata, Y; Ogawa, Y; Oue, K; Sakai, N; Shimizu, Y; Yoshida, M | 1 |
| Hutchinson, MR; Iqbal, S; Kapur, D; Moh, ESX; Nishtala, K; Packer, NH; Staikopoulos, V | 1 |
12 review(s) available for baclofen and morphine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Uropharmacology: X. Central nervous system stimulants and depressants.
Topics: Amphetamines; Anesthetics; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Baclofen; Benzodiazepines; Central Nervous System Agents; Chloral Hydrate; Humans; Imipramine; Levodopa; Meperidine; Meprobamate; Morphine; Nortriptyline; Paraldehyde; Phenothiazines; Phenytoin; Picrotoxin; Reserpine; Strychnine; Urinary Tract | 1979 |
Advances in drug delivery systems and applications in neurosurgery.
Topics: Adult; Aged; Aged, 80 and over; Animals; Baclofen; Brain Diseases; Equipment Design; Female; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Middle Aged; Morphine; Muscle Spasticity; Neurosurgery; Pain, Intractable | 1991 |
Dorsal horn neuropharmacology: baclofen and morphine.
Topics: Animals; Baclofen; Endorphins; gamma-Aminobutyric Acid; Humans; Morphine; Narcotics; Neurons; Receptors, Opioid; Spinal Cord; Stereoisomerism; Synapses | 1988 |
Drug pumps for treatment of neurologic diseases and pain.
Topics: Alzheimer Disease; Baclofen; Bethanechol; Bethanechol Compounds; Catheters, Indwelling; Chronic Disease; Epidural Space; Humans; Injections; Morphine; Muscle Spasticity; Neoplasms; Nervous System Diseases; Pain | 1985 |
GABA in morphine analgesia and tolerance.
Topics: Analgesia; Animals; Baclofen; Benzodiazepines; Bicuculline; Brain Chemistry; Cyclohexanecarboxylic Acids; Drug Tolerance; GABA Antagonists; gamma-Aminobutyric Acid; Mice; Morphine; Muscimol; Naloxone; Picrotoxin; Rats; Receptors, GABA-A; Synaptic Transmission | 1985 |
Intrathecal application of drugs for muscle hypertonia.
Topics: Baclofen; Humans; Injections, Spinal; Midazolam; Morphine; Muscle Hypertonia | 1988 |
[Functional neurosurgery of cerebral palsy].
Topics: Adolescent; Adult; Animals; Baclofen; Benzodiazepines; Brain; Brain Diseases; Cerebellar Cortex; Cerebellar Nuclei; Cerebellum; Cerebral Palsy; Child; Child, Preschool; Drug Implants; Electric Stimulation Therapy; Female; Follow-Up Studies; Glycine; Humans; Infant, Newborn; Infant, Premature; Injections, Spinal; Morphine; Muscle Spasticity; Nervous System; Neurosurgical Procedures; Physical Therapy Modalities; Pregnancy; Reflex; Spinal Cord; Spinal Nerve Roots; Thalamus | 1985 |
Intrathecal drug delivery 2002.
Topics: Baclofen; Drug Approval; Humans; Infusion Pumps, Implantable; Injections, Spinal; Morphine; Movement Disorders; Pain; Practice Patterns, Physicians'; Spinal Cord; United States | 2003 |
[Palliative medicine for advanced gynecological malignancy].
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Bone Neoplasms; Drug Therapy, Combination; Female; GABA Agonists; Genital Neoplasms, Female; Humans; Ketamine; Morphine; Muscle Neoplasms; Neoplasm Invasiveness; Nerve Block; Oxycodone; Pain, Intractable; Palliative Care; Peritonitis; Receptors, N-Methyl-D-Aspartate | 2004 |
[Chronic intrathecal drug administration for the control of intractable pain].
Topics: Amines; Analgesics, Opioid; Anesthetics, Local; Baclofen; Calcium Channel Blockers; Clonidine; Cyclohexanecarboxylic Acids; Drug Therapy, Combination; GABA Agonists; Gabapentin; gamma-Aminobutyric Acid; Humans; Infusion Pumps, Implantable; Injections, Spinal; Morphine; Neoplasms; Neuralgia; omega-Conotoxins; Pain, Intractable | 2008 |
Ziconotide combination intrathecal therapy: rationale and evidence.
Topics: Analgesics; Baclofen; Clonidine; Drug Therapy, Combination; Humans; Injections, Spinal; Morphine; omega-Conotoxins; Pain; Treatment Outcome | 2010 |
3 trial(s) available for baclofen and morphine
| Article | Year |
|---|---|
Enhancement of morphine analgesia by the GABAB agonist baclofen.
Topics: Adult; Analysis of Variance; Baclofen; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Male; Morphine; Pain, Postoperative; Pentazocine; Time Factors | 1995 |
Intrathecal baclofen and morphine in multiple sclerosis patients with severe pain and spasticity.
Topics: Adult; Baclofen; Drug Therapy, Combination; Female; Humans; Injections, Spinal; Male; Middle Aged; Morphine; Multiple Sclerosis; Muscle Relaxants, Central; Muscle Spasticity; Narcotics; Pain | 2007 |
Intrathecal baclofen for postoperative analgesia after total knee arthroplasty.
Topics: Aged; Analgesics, Opioid; Anesthesia, Spinal; Anesthetics, Local; Arthroplasty, Replacement, Knee; Baclofen; Bupivacaine; Double-Blind Method; Endpoint Determination; Female; Follow-Up Studies; GABA Agonists; Humans; Male; Middle Aged; Morphine; Pain Measurement; Pain, Postoperative; Preanesthetic Medication; Prospective Studies | 2009 |
134 other study(ies) available for baclofen and morphine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.
Topics: Anti-Inflammatory Agents; Cell Membrane Permeability; Cluster Analysis; Drug Evaluation, Preclinical; Humans; Models, Biological; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Regression Analysis; Skin; Skin Absorption | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Effects of various amino acids and their related agents in association with neurotransmitter substances on the morphine-induced Straub tail reaction in mice.
Topics: Amino Acids; Animals; Baclofen; Mice; Morphine; Synaptic Transmission; Tail | 1978 |
Analgesia produced by microinjection of baclofen and morphine at brain stem sites.
Topics: Analgesics; Animals; Baclofen; Brain; Brain Stem; Cerebral Aqueduct; Female; Microinjections; Morphine; Rats; Reaction Time | 1979 |
[Effects of beta-(p-chlorophenyl)-GABA (baclofen) on response to noxious stimuli (author's transl)].
Topics: Aminobutyrates; Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Synergism; Male; Mephenesin; Mice; Morphine; Muscle Relaxants, Central; Rats | 1977 |
Delimitation of neuronal substrates necessary for the analgesic action of baclofen and morphine.
Topics: Aminobutyrates; Analgesics; Animals; Baclofen; Brain Stem; Central Nervous System; Female; Morphine; Neurons; Rats; Reaction Time; Spinal Cord | 1978 |
The analgesic action of baclofen [beta-(4-chlorophenyl)-gamma-aminobutyric acid].
Topics: Aminobutyrates; Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Male; Mice; Morphine; Motor Skills; Naloxone; Postural Balance; Reaction Time | 1977 |
Alternative approaches to analgesia: baclofen as a model compound.
Topics: Aminobutyrates; Analgesics; Animals; Baclofen; Drug Interactions; Hot Temperature; Male; Mice; Morphine; Motor Activity; Reaction Time; Time Factors | 1975 |
Regulation of somatodendritic dopamine release in the ventral tegmental area by opioids and GABA: an in vivo microdialysis study.
Topics: Afferent Pathways; Animals; Baclofen; Biological Transport; Dendrites; Dialysis; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Interneurons; Kinetics; Male; Models, Neurological; Morphine; Muscimol; Naloxone; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tegmentum Mesencephali; Time Factors | 1992 |
Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesia; Animals; Baclofen; Brain; Glyburide; Injections, Intraventricular; Male; Mice; Morphine; Norepinephrine; Potassium Channels; Pyrrolidines; Spinal Cord | 1992 |
CGP 35348, a new GABAB antagonist, prevents antinociception and muscle-relaxant effect induced by baclofen.
Topics: Analgesics; Animals; Baclofen; GABA Antagonists; GABA-A Receptor Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Muscle Relaxation; Muscles; Organophosphorus Compounds; Oxotremorine; Postural Balance; Rats; Rats, Inbred Strains; Reaction Time | 1991 |
Gamma-aminobutyric acidA (GABAA) receptor modulation of morphine inhibition of norepinephrine release.
Topics: Animals; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Morphine; Norepinephrine; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
gamma-Aminobutyric acid inhibits the potassium-stimulated release of somatostatin from rat spinal cord slices.
Topics: Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Morphine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord | 1990 |
GABAA and GABAB antagonists prevent the opioid inhibition of endogenous acetylcholine release evoked by glutamate from rat neostriatal slices.
Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Morphine; Narcotics; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
GABAergic mechanisms in morphine-induced hypothermia.
Topics: 4-Aminobutyrate Transaminase; Alkynes; Aminocaproates; Animals; Baclofen; Body Temperature; Female; Flumazenil; gamma-Aminobutyric Acid; Male; Morphine; Rats; Rats, Inbred Strains | 1990 |
[The effect of flupirtine, various analgesics and muscle relaxants on skeletal muscle tone in the conscious rat].
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Baclofen; Benzodiazepines; Benzodiazepinones; Codeine; Dantrolene; Diazepam; Female; Mephenesin; Morphine; Motor Activity; Muscle Relaxants, Central; Muscle Tonus; Rats; Rats, Inbred Strains; Tramadol | 1990 |
Desensitization to substance P following intrathecal injection. A technique for investigating the role of substance P in nociception.
Topics: Animals; Baclofen; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Sensory Thresholds; Substance P; Time Factors | 1985 |
Intradermal hypertonic saline-induced behavior as a nociceptive test in mice.
Topics: Animals; Anti-Inflammatory Agents; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; Injections, Intradermal; Injections, Spinal; Male; Mice; Morphine; Nalorphine; Pain; Pentazocine; Saline Solution, Hypertonic; Sodium Chloride; Spinal Cord; Substance P | 1986 |
GABAergic agents-induced antinociceptive effect in mice.
Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; Muscimol; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Valproic Acid | 1989 |
Effect of intrathecal baclofen on bladder and sphincter function.
Topics: Baclofen; Female; Humans; Infusion Pumps; Injections, Spinal; Male; Morphine; Muscle Spasticity; Myelitis, Transverse; Spinal Cord Injuries; Urinary Bladder, Neurogenic; Urinary Catheterization; Urodynamics | 1989 |
Effects of central nervous system-acting drugs on urinary bladder contraction in unanesthetized rats.
Topics: Anesthesia; Animals; Baclofen; Behavior, Animal; Central Nervous System Agents; Diazepam; Male; Morphine; Muscle Contraction; Muscle, Smooth; Pentobarbital; Rats; Rats, Inbred Strains; Urinary Bladder; Urination | 1989 |
[Role of opioid and adrenergic mechanisms in the analgesic action of GABA-positive drugs].
Topics: 4-Aminobutyrate Transaminase; Analgesics; Animals; Baclofen; Clonidine; Drug Tolerance; Female; Male; Morphine; Nociceptors; Pain Measurement; Rats; Receptors, Adrenergic, alpha; Receptors, GABA-A; Valproic Acid | 1988 |
Decreased response to GABA-B agonists in longitudinal smooth muscle-myenteric plexus preparations from morphine-tolerant guinea-pigs.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; Male; Morphine; Muscle, Smooth; Receptors, GABA-A | 1988 |
Urodynamic studies after intrathecal administration of baclofen and morphine in dogs.
Topics: Animals; Baclofen; Dogs; Female; Injections, Spinal; Morphine; Muscle, Smooth; Spinal Cord; Urethra; Urinary Bladder; Urodynamics | 1989 |
A method for studying pain arising from the urinary bladder in conscious, freely-moving rats.
Topics: Animals; Baclofen; Behavior, Animal; Consciousness; Female; Morphine; Nociceptors; Pain; Rats; Sensation; Urinary Bladder; Xylenes | 1989 |
D-Baclofen is an antagonist at baclofen receptors mediating antinociception in the spinal cord.
Topics: Alkynes; Aminobutyrates; Aminocaproates; Analgesics; Animals; Baclofen; Carbamazepine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Morphine; Norepinephrine; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Receptors, GABA-B; Spinal Cord | 1985 |
[Theophylline-induced changes in the presynaptic effects of adenosine, baclofen, clofelin and morphine in the myenteric plexus of the guinea pig].
Topics: Adenosine; Animals; Baclofen; Clonidine; Drug Interactions; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Myenteric Plexus; Receptors, Cholinergic; Receptors, Neurotransmitter; Theophylline | 1987 |
GABAA-antagonists and baclofen analgesia.
Topics: Analgesia; Animals; Baclofen; Bicuculline; GABA Antagonists; Injections, Intraperitoneal; Male; Mice; Morphine; Naloxone; Picrotoxin; Time Factors | 1988 |
[Potentiation concept in pharmacology].
Topics: 5-Hydroxytryptophan; Animals; Baclofen; Clomipramine; Diazepam; Drug Synergism; Drug Therapy, Combination; Fentanyl; Humans; Morphine; Nimodipine; Pain; Proglumide; Rats | 1988 |
Influence of adrenergic and cholinergic mechanisms in baclofen induced analgesia.
Topics: Analgesics; Animals; Atropine; Baclofen; Dose-Response Relationship, Drug; In Vitro Techniques; Mecamylamine; Mice; Morphine; Motor Activity; Neostigmine; Parasympathetic Nervous System; Physostigmine; Reaction Time; Sympathetic Nervous System | 1988 |
Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen.
Topics: Adenylate Cyclase Toxin; Analgesics; Animals; Baclofen; Body Weight; Injections, Spinal; Male; Morphine; Norepinephrine; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1988 |
The role of GABA in morphine abstinence in rats.
Topics: Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Male; Morphine; Rats; Rats, Inbred Strains; Serotonin; Substance Withdrawal Syndrome | 1988 |
Controversies in the surgical management of spasticity.
Topics: Baclofen; Electric Stimulation Therapy; Humans; Injections, Spinal; Morphine; Muscle Spasticity; Spinal Cord; Spinal Nerve Roots | 1986 |
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Morphine; Motor Activity; Pain; Pyrans; Pyrones | 1987 |
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine | 1985 |
gamma-Aminobutyric acid-ergic analgesia: implications for gamma-aminobutyric acid-ergic therapy for drug addictions.
Topics: Animals; Baclofen; Brain; Drug Tolerance; Endorphins; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Mice; Morphine; Morphine Dependence; Muscimol; Nociceptors; Rats; Receptors, GABA-A; Sensory Thresholds; Substance Withdrawal Syndrome; Substance-Related Disorders | 1984 |
Studies in the primate on the analgetic effects associated with intrathecal actions of opiates, alpha-adrenergic agonists and baclofen.
Topics: Adrenergic alpha-Agonists; Analgesia; Animals; Avoidance Learning; Baclofen; Behavior, Animal; Cats; Clonidine; Drug Interactions; Electroshock; Female; Injections, Spinal; Macaca; Macaca mulatta; Male; Meperidine; Morphine; Naloxone; Narcotics; Pain; Phentolamine; Sensory Thresholds; Spinal Cord | 1981 |
Analgesic potencies of non-narcotic, narcotic and anesthetic drugs as determined by the bradykinin-induced biting-like responses in rats.
Topics: Analgesics; Analgesics, Opioid; Anesthetics; Animals; Baclofen; Bradykinin; Chloralose; Dose-Response Relationship, Drug; Indomethacin; Lidocaine; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains | 1983 |
Neurotransmitter-blocking agents influence antinociceptive effects of carbamazepine, baclofen, pentazocine and morphine on bradykinin-induced trigeminal pain.
Topics: Analgesics; Animals; Atropine; Baclofen; Bicuculline; Bradykinin; Carbamazepine; Haloperidol; Male; Methysergide; Morphine; Naloxone; Neurotransmitter Agents; Pentazocine; Rats; Rats, Inbred Strains; Sympatholytics; Trigeminal Neuralgia; Trigeminal Nucleus, Spinal | 1984 |
Tail-pinch method in vitro and the effects of some antinociceptive compounds.
Topics: Analgesics; Animals; Animals, Newborn; Baclofen; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Morphine; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Somatostatin; Spinal Cord; Stereotyped Behavior; Tail | 1984 |
Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline.
Topics: Afferent Pathways; Animals; Baclofen; Dose-Response Relationship, Drug; Eledoisin; Male; Morphine; Nociceptors; Norepinephrine; Physalaemin; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1984 |
GABAergic drugs, morphine and morphine tolerance: a study in relation to nociception and gastrointestinal transit in mice.
Topics: Aminooxyacetic Acid; Analgesia; Animals; Baclofen; Bicuculline; Cyclohexanecarboxylic Acids; Digestion; Digestive System; Digestive System Physiological Phenomena; Drug Tolerance; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Naloxone; Nociceptors; Oxazoles; Picrotoxin | 1983 |
Analgesic properties of the GABA-mimetic THIP.
Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time | 1981 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA | 1995 |
The distribution of medication along the spinal canal after chronic intrathecal administration.
Topics: Analgesia, Epidural; Baclofen; Endometrial Neoplasms; Female; Humans; Hydromorphone; Infusion Pumps, Implantable; Injections, Spinal; Male; Morphine; Multiple Sclerosis; Muscle Spasticity; Pain, Intractable; Prostatic Neoplasms; Reflex Sympathetic Dystrophy; Spinal Cord; Spinal Cord Injuries | 1993 |
Managing chronic intractable pain.
Topics: Baclofen; Humans; Infusion Pumps, Implantable; Morphine; Pain, Intractable | 1995 |
Compatibility of morphine, baclofen, floxuridine and fluorouracil in an implantable medication pump.
Topics: Baclofen; Chromatography, High Pressure Liquid; Drug Incompatibility; Drug Stability; Floxuridine; Fluorouracil; Infusion Pumps, Implantable; Morphine; Solutions; Spectrophotometry, Ultraviolet | 1995 |
Complications of spinal opioid therapy: myoclonus, spastic muscle tone and spinal jerking.
Topics: Administration, Oral; Analgesia; Analgesia, Epidural; Baclofen; Clonazepam; Female; Humans; Infusions, Intravenous; Injections, Spinal; Male; Middle Aged; Morphine; Muscle Spasticity; Muscle Tonus; Myoclonus; Retrospective Studies; Risk Factors; Spinal Cord; Spinal Cord Diseases | 1994 |
Pre-emptive administration of clonidine prevents development of hyperalgesia to mechanical stimuli in a model of mononeuropathy in the rat.
Topics: Analysis of Variance; Animals; Baclofen; Carbamazepine; Clonidine; Disease Models, Animal; Hyperalgesia; Male; Morphine; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Time Factors | 1993 |
Hypotension following a trial intrathecal dose of baclofen.
Topics: Adult; Baclofen; Humans; Hypotension; Injections, Spinal; Male; Morphine; Spasm | 1993 |
Effects of excitatory amino acid receptor antagonists on a capsaicin-evoked nociceptive reflex: a comparison with morphine, clonidine and baclofen.
Topics: Animals; Baclofen; Capsaicin; Clonidine; Evoked Potentials; In Vitro Techniques; Morphine; Nociceptors; Rats; Receptors, Amino Acid; Reflex; Spinal Cord | 1993 |
Cromakalim differentially enhances antinociception induced by agonists of alpha(2)adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors.
Topics: Animals; Baclofen; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred Strains; Morphine; Nociceptors; Pain; Pyrroles; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vasodilator Agents | 1996 |
Piracetam and aniracetam antagonism of centrally active drug-induced antinociception.
Topics: Analgesics; Analgesics, Opioid; Animals; Baclofen; Bicuculline; Male; Mice; Morphine; Nootropic Agents; Pain Measurement; Pain Threshold; Picrotoxin; Piracetam; Postural Balance; Pyrrolidinones; Receptors, GABA-B | 1996 |
Effects of GABA receptor antagonists injected spinally on antinociception induced by opioids administered supraspinally in mice.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Baclofen; beta-Endorphin; Dose-Response Relationship, Drug; GABA Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Pain Measurement; Pyridazines; Reaction Time; Receptors, Opioid; Receptors, Opioid, mu | 1996 |
Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Baclofen; Cholinesterase Inhibitors; Clomipramine; Diphenhydramine; Drug Antagonism; GABA Agonists; Histamine H1 Antagonists; Injections, Intraventricular; Male; Mice; Morphine; Pain Measurement; Pertussis Toxin; Physostigmine; Virulence Factors, Bordetella | 1996 |
Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; Male; Microinjections; Morphine; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 1996 |
Complications associated with infusion pumps implanted for spasticity.
Topics: Adult; Aged; Baclofen; Equipment Failure; Female; Humans; Infusion Pumps; Male; Middle Aged; Morphine; Muscle Spasticity; Prostheses and Implants; Surgical Wound Infection | 1995 |
Local opioid withdrawal in rat single periaqueductal gray neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Baclofen; Bicuculline; Clonidine; Drug Tolerance; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Male; Membrane Potentials; Morphine; Naloxone; Narcotic Antagonists; Neurons; Organ Culture Techniques; Periaqueductal Gray; Potassium Channels; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Substance Withdrawal Syndrome; Tetrodotoxin; Time Factors; Valine | 1996 |
Disappearance of gamma-aminobutyric acid (GABA)B receptor-mediated cAMP suppression in mouse cerebrum after chronic treatment with morphine.
Topics: Animals; Baclofen; Blotting, Western; Cerebral Cortex; Cyclic AMP; Male; Mice; Morphine; Receptors, GABA-B; Substance Withdrawal Syndrome | 1996 |
Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; Drug Tolerance; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; GABA-B Receptor Agonists; Guinea Pigs; Hypothalamus; In Vitro Techniques; Membrane Potentials; Morphine; Morphine Dependence; Neurons; Receptors, Opioid, mu; Tetrodotoxin; Tyrosine 3-Monooxygenase | 1997 |
Differential modulation by muscimol and baclofen on antinociception induced by morphine, beta-endorphin, D-Pen2,5-enkephalin and U50,488H administered intracerebroventricularly in the mouse.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Analgesics; Analysis of Variance; Animals; Baclofen; beta-Endorphin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Mice; Morphine; Muscimol; Pyrrolidines; Receptors, GABA; Receptors, Opioid, kappa | 1995 |
An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen.
Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Drug Design; Gene Expression Regulation; Kv1.1 Potassium Channel; Male; Mice; Morphine; Oligonucleotides, Antisense; Potassium Channels; Potassium Channels, Voltage-Gated | 1997 |
[Myoclonus resulting from high-dose epidural and intravenous morphine infusion].
Topics: Adult; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Female; GABA Agonists; Humans; Injections, Intravenous; Lymphatic Metastasis; Morphine; Myoclonus; Pain, Intractable; Rectal Neoplasms | 1997 |
Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Baclofen; Behavior, Animal; Carbamazepine; Constriction, Pathologic; GABA Agonists; Male; Morphine; Pain Measurement; Physical Stimulation; Postural Balance; Rats; Rats, Sprague-Dawley; Skin; Trigeminal Nerve; Trigeminal Neuralgia | 1999 |
Urodynamics in acetone-induced cystitis of anesthetized rats.
Topics: Acetone; Administration, Intravesical; Animals; Atropine; Baclofen; Carbachol; Cystitis; Electric Stimulation; In Vitro Techniques; Male; Morphine; Muscle Contraction; Pressure; Rats; Rats, Wistar; Urinary Bladder; Urination; Urodynamics | 1999 |
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Morphine; Pain; Pain Measurement; Receptors, Cholecystokinin | 1999 |
GABAB receptors are involved in the control of acute opiate withdrawal in isolated tissue.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Antagonists; Guinea Pigs; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Opioid-Related Disorders; Receptors, GABA-B; Substance Withdrawal Syndrome | 1999 |
Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat.
Topics: Animals; Baclofen; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Hyperalgesia; Insulin; Male; Morphine; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Streptozocin | 1999 |
The interaction of antinociceptive effects of morphine and GABA receptor agonists within the rat spinal cord.
Topics: Analgesics, Opioid; Animals; Baclofen; Colon; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; GABA Agonists; Hot Temperature; Injections, Spinal; Male; Morphine; Muscimol; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley | 1999 |
Effects of intrathecal morphine, clonidine and baclofen on allodynia after partial sciatic nerve injury in the rat.
Topics: Analgesics; Analgesics, Opioid; Animals; Baclofen; Clonidine; Cold Temperature; Dose-Response Relationship, Drug; GABA Agonists; Injections, Spinal; Male; Morphine; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1999 |
Differential modulation by baclofen on antinociception induced by morphine and beta-endorphin administered intracerebroventricularly in the formalin test.
Topics: Analgesics, Opioid; Animals; Baclofen; beta-Endorphin; Brain Chemistry; Fixatives; Formaldehyde; GABA Agonists; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Nociceptors; Pain Threshold; Receptors, GABA-A; Receptors, GABA-B | 1999 |
Ziconotide for the treatment of severe spasticity after spinal cord injury.
Topics: Adult; Analgesics, Opioid; Baclofen; Calcium Channel Blockers; Drug Resistance; Humans; Male; Morphine; Muscle Relaxants, Central; Muscle Spasticity; omega-Conotoxins; Paraplegia; Quadriplegia; Spinal Cord Injuries | 2000 |
Nociceptin attenuates opioid and gamma-aminobutyric acid(B) receptor-mediated analgesia in the mouse tail-flick assay.
Topics: Analgesics, Opioid; Animals; Baclofen; Dynorphins; GABA Agonists; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Nociceptin; Nociceptors; Opioid Peptides; Pain Threshold; Receptors, GABA-B; Receptors, Opioid; Spinal Cord; Tail | 2000 |
GABA(B) receptor mechanism and imipramine-induced antinociception in ligated and non-ligated mice.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Baclofen; GABA Agonists; GABA Antagonists; Imipramine; Ligation; Male; Mice; Morphine; Organophosphorus Compounds; Pain Measurement; Receptors, GABA-B; Sciatic Nerve | 2000 |
Lack of sex-related differences in the prevention by baclofen of the morphine withdrawal syndrome in mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Defecation; Estrus; Female; GABA Agonists; Male; Mice; Morphine; Morphine Dependence; Reflex; Sex Characteristics; Substance Withdrawal Syndrome | 2001 |
Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity.
Topics: Animals; Apomorphine; Baclofen; Drug Tolerance; GABA Agonists; Hyperkinesis; Male; Mice; Mice, Inbred ICR; Monitoring, Physiologic; Morphine; Motor Activity; Receptors, Dopamine; Synapses; Time Factors | 2001 |
Effects of intrathecal morphine, baclofen, clonidine and R-PIA on the acute allodynia-like behaviours after spinal cord ischaemia in rats.
Topics: Adenosine; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Clonidine; Female; GABA Agonists; Injections, Spinal; Ischemia; Morphine; Neuralgia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sodium Chloride; Spinal Cord | 2001 |
GABA mechanisms and antinociception in mice with ligated sciatic nerve.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; Ligation; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Naloxone; Organophosphorus Compounds; Pain; Pain Measurement; Sciatic Nerve | 2001 |
Opiate-induced motor stimulation is regulated by gamma-aminobutyric acid type B receptors found in the ventral tegmental area in mice.
Topics: Animals; Baclofen; Dopamine; Drug Interactions; Feedback; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Narcotics; Neural Inhibition; Neural Pathways; Neurons; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Synaptic Transmission; Ventral Tegmental Area | 2002 |
Effect of intracerebroventricular injection of GABA receptor agents on morphine-induced antinociception in the formalin test.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Agents; GABA Agonists; GABA Antagonists; Injections, Intraventricular; Male; Morphine; Muscimol; Organophosphorus Compounds; Pain Measurement; Rats; Receptors, GABA | 2002 |
Combined intrathecal baclofen and morphine infusion for the treatment of spasticity related pain and central deafferentiation pain.
Topics: Afferent Pathways; Analgesics, Opioid; Baclofen; Central Nervous System Diseases; Denervation; Drug Therapy, Combination; Humans; Injections, Spinal; Morphine; Muscle Relaxants, Central; Muscle Spasticity; Pain; Palliative Care | 2002 |
Baclofen prevents morphine withdrawal irrespective of seasonal variation.
Topics: Animals; Arousal; Baclofen; Female; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Seasons; Substance Withdrawal Syndrome | 2002 |
Reversible coma in children after improper baclofen pump insertion.
Topics: Analgesics, Opioid; Baclofen; Cerebral Palsy; Child; Child, Preschool; Coma; Female; GABA Agonists; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Morphine; Postoperative Complications | 2002 |
The 5-HT(1A) receptor agonist F 13640 attenuates mechanical allodynia in a rat model of trigeminal neuropathic pain.
Topics: Aminopyridines; Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Morphine; Muscle Relaxants, Central; Narcotics; Pain; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Stress, Mechanical; Trigeminal Neuralgia | 2002 |
The role of surgical placement and pump orientation in intrathecal pump system failure: a technical report.
Topics: Analgesia, Epidural; Baclofen; Catheters, Indwelling; Cerebral Palsy; Child; Device Removal; Equipment Failure Analysis; Humans; Ilium; Infusion Pumps, Implantable; Injections, Spinal; Morphine; Pain; Radiography; Reoperation; Retrospective Studies; Ribs | 2003 |
Baclofen antagonizes nicotine-, cocaine-, and morphine-induced dopamine release in the nucleus accumbens of rat.
Topics: Animals; Baclofen; Cocaine; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; GABA Agonists; GABA-B Receptor Agonists; Male; Microdialysis; Morphine; Neural Pathways; Nicotine; Nucleus Accumbens; Rats; Receptors, GABA-B; Reward; Substance-Related Disorders; Synaptic Transmission; Up-Regulation | 2003 |
Baclofen pumps: comment on Anderson et al.
Topics: Anti-Arrhythmia Agents; Atropine; Baclofen; Child; Coma; GABA Agonists; Humans; Infusion Pumps, Implantable; Morphine; Naloxone; Narcotic Antagonists; Oxygen; Postoperative Complications | 2003 |
Changes in G-protein activity mediated through the stimulation of dopamine and GABA(B) receptors in the mesolimbic dopaminergic system of morphine-sensitized mice.
Topics: Animals; Baclofen; Binding Sites; Dopamine Antagonists; GABA Agonists; GTP-Binding Proteins; Haloperidol; Limbic System; Locomotion; Male; Mice; Morphine; Narcotics; Prosencephalon; Receptors, Dopamine; Receptors, GABA-B | 2003 |
Baclofen inhibits opiate-induced conditioned place preference and associated induction of Fos in cortical and limbic regions.
Topics: Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Brain; Conditioning, Operant; GABA Agonists; Gyrus Cinguli; Immunohistochemistry; Limbic System; Male; Mice; Mice, Inbred C57BL; Morphine; Nucleus Accumbens; Prosencephalon; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Reward | 2003 |
Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literature.
Topics: Adult; Baclofen; Drug Tolerance; Humans; Infusion Pumps, Implantable; Injections, Spinal; Male; Morphine; Muscle Relaxants, Central; Muscle Spasticity; Narcotics; Spinal Cord Injuries | 2003 |
GABA(B) receptor activation in the ventral tegmental area inhibits the acquisition and expression of opiate-induced motor sensitization.
Topics: Animals; Baclofen; Drug Administration Routes; Drug Combinations; Drug Interactions; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Narcotics; Proto-Oncogene Proteins c-fos; Receptors, GABA-B; Ventral Tegmental Area | 2004 |
Efficacy of intrathecal morphine in the treatment of baclofen tolerance in a patient on intrathecal baclofen therapy (ITB).
Topics: Adult; Baclofen; Drug Tolerance; Female; Humans; Injections, Spinal; Morphine; Paraplegia | 2004 |
Suppression by baclofen of the stimulation of alcohol intake induced by morphine and WIN 55,212-2 in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Baclofen; Benzoxazines; Cannabinoid Receptor Agonists; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; Injections, Intraperitoneal; Male; Morphine; Morpholines; Naphthalenes; Rats; Receptors, GABA-B | 2004 |
Correlation between withdrawal symptoms and medication pump residual volume in patients with implantable SynchroMed pumps.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Bupivacaine; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Equipment Design; Equipment Failure; Female; Fentanyl; Humans; Hydromorphone; Infusion Pumps, Implantable; Male; Middle Aged; Morphine; Muscle Spasticity; Neurologic Examination; Pain, Intractable; Quality of Life; Retrospective Studies; Substance Withdrawal Syndrome | 2004 |
Baclofen reestablishes micro-opioid receptor levels modified by morphine withdrawal syndrome in either sex.
Topics: Animals; Baclofen; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; GABA Agonists; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Sex Factors; Substance Withdrawal Syndrome | 2004 |
Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat.
Topics: Alkanesulfonates; Amines; Amitriptyline; Animals; Baclofen; Behavior, Animal; Benzoxazines; Carbamazepine; Cyclohexanecarboxylic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Gabapentin; gamma-Aminobutyric Acid; Indans; Male; Molecular Structure; Morphine; Morpholines; Naphthalenes; Nitriles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sulfonic Acids | 2004 |
Opioid tolerance in periaqueductal gray neurons isolated from mice chronically treated with morphine.
Topics: Analgesics, Opioid; Animals; Baclofen; Calcium Channels; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Morphine; Neurons; Pain Measurement; Periaqueductal Gray; Receptors, Opioid, mu | 2005 |
Effect of a selective GABA(B) receptor agonist baclofen on the mu-opioid receptor agonist-induced antinociceptive, emetic and rewarding effects.
Topics: Analgesics, Opioid; Animals; Baclofen; Conditioning, Operant; Ferrets; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Morphine; Organophosphorus Compounds; Pain Measurement; Rats; Reaction Time; Receptors, Opioid, mu; Reward; Vomiting | 2005 |
Different effects of GABAergic receptors located in the ventral tegmental area on the expression of morphine-induced conditioned place preference in rat.
Topics: Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Bicuculline; Conditioning, Operant; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Morphine; Muscimol; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA; Receptors, GABA-A; Receptors, GABA-B; Ventral Tegmental Area | 2005 |
Measurement of peripheral muscle resistance in rats with chronic ischemia-induced paraplegia or morphine-induced rigidity using a semi-automated computer-controlled muscle resistance meter.
Topics: Anesthetics, Inhalation; Animals; Baclofen; Chronic Disease; Electromyography; Halothane; Injections, Spinal; Ischemia; Morphine; Muscle Contraction; Muscle Relaxants, Central; Muscle Rigidity; Muscle, Skeletal; Narcotics; Paraplegia; Rats; Rhizotomy; Signal Processing, Computer-Assisted; Spinal Cord; Spinal Nerve Roots | 2005 |
Morphine withdrawal syndrome and its prevention with baclofen: Autoradiographic study of mu-opioid receptors in prepubertal male and female mice.
Topics: Aging; Animals; Autoradiography; Baclofen; Binding Sites; Brain; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Female; GABA Agonists; Male; Mice; Morphine; Morphine Dependence; Narcotic Antagonists; Narcotics; Receptors, Opioid, mu; Sex Characteristics; Substance Withdrawal Syndrome | 2006 |
Behavioral and electrophysiological evidence for opioid tolerance in adolescent rats.
Topics: Action Potentials; Age Factors; Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Electrophysiology; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reaction Time | 2007 |
Effect of GABA receptor agonists or antagonists on morphine-induced Straub tail in mice.
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; Hindlimb Suspension; Male; Mice; Morphine; Muscimol; Narcotics; Organophosphorus Compounds; Picrotoxin | 2006 |
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Baclofen; Cells, Cultured; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Flow Cytometry; GABA Agonists; Ganglia, Spinal; Membrane Potentials; Mice; Mice, Knockout; Morphine; Neurons; Patch-Clamp Techniques; Protein Transport; Receptors, Opioid, mu; Time Factors; Transfection | 2006 |
GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol.
Topics: Animals; Baclofen; Breeding; Central Nervous System Stimulants; Ethanol; Female; GABA-B Receptor Agonists; Male; Mice; Morphine; Motor Activity; Narcotics | 2006 |
A GABA(B) agonist reverses the behavioral sensitization to morphine in rats.
Topics: Animals; Baclofen; Behavior, Animal; Drug Administration Schedule; Drug Delivery Systems; GABA Agonists; Male; Morphine; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Substance-Related Disorders | 2007 |
The complications of scar formation associated with intrathecal pump placement.
Topics: Adult; Analgesics, Opioid; Baclofen; Catheters, Indwelling; Cicatrix; Dystonia; Equipment Failure Analysis; Foreign-Body Migration; Humans; Infusion Pumps, Implantable; Injections, Spinal; Low Back Pain; Male; Morphine; Muscle Relaxants, Central | 2007 |
Attenuation of morphine withdrawal signs by a GABAB receptor agonist in the locus coeruleus of rats.
Topics: Analysis of Variance; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Therapy, Combination; GABA Agonists; GABA Antagonists; Injections, Subcutaneous; Locus Coeruleus; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Narcotics; Organophosphorus Compounds; Rats; Rats, Wistar; Substance Withdrawal Syndrome | 2009 |
GABAB receptors within the ventral tegmental area are involved in the expression and acquisition of morphine-induced place preference in morphine-sensitized rats.
Topics: Animals; Baclofen; Conditioning, Operant; Dose-Response Relationship, Drug; Female; GABA Agonists; GABA Antagonists; Microinjections; Morphine; Motor Activity; Narcotics; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, GABA-B; Reinforcement, Psychology; Ventral Tegmental Area | 2009 |
Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Baclofen; Behavior, Animal; Bicuculline; Conditioning, Operant; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; Male; Morphine; N-Methylaspartate; Narcotics; Pedunculopontine Tegmental Nucleus; Rats; Rats, Wistar; Receptors, GABA-B; Receptors, Glutamate; Reward | 2009 |
Role for GABA agonists in the nucleus accumbens in regulating morphine self-administration.
Topics: Animals; Baclofen; GABA Agonists; Male; Microinjections; Morphine; Muscimol; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Reinforcement, Psychology; Self Administration | 2009 |
Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; beta-Endorphin; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression; Hypothalamus; Male; Mice; Mice, Inbred ICR; Morphine; Muscimol; Naltrexone; Narcotic Antagonists; Narcotics; Pro-Opiomelanocortin; Substance Withdrawal Syndrome | 2009 |
Baclofen enhances extinction of opiate conditioned place preference.
Topics: Analgesics, Opioid; Animals; Baclofen; Conditioning, Classical; Dose-Response Relationship, Drug; Extinction, Psychological; GABA Agonists; Mice; Mice, Inbred C57BL; Morphine; Motor Activity; Space Perception; Time Factors | 2010 |
Long-term adaptation to high doses of morphine causes desensitization of mu-OR- and delta-OR-stimulated G-protein response in forebrain cortex but does not decrease the amount of G-protein alpha subunits.
Topics: Adaptation, Physiological; Animals; Baclofen; Behavior, Animal; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Morphine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Time Factors | 2010 |
Persistent non-cancer pain management in the older adult.
Topics: Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Baclofen; Drug Therapy, Combination; Female; GABA Agonists; Humans; Morphine; Pain; Pain Measurement | 2010 |
Single and repeated baclofen treatment attenuates the discriminative stimulus effects of morphine in rats.
Topics: Analgesics, Opioid; Animals; Baclofen; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA Agonists; Injections, Intraperitoneal; Male; Morphine; Rats; Rats, Sprague-Dawley | 2010 |
Simultaneous treatment of intractable pain and spasticity: observations of combined intrathecal baclofen-morphine therapy over a 10-year clinical experience.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Baclofen; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Injections, Spinal; Male; Middle Aged; Morphine; Muscle Relaxants, Central; Muscle Spasticity; Pain Measurement; Pain, Intractable; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult | 2012 |
The γ-aminobutyric acid type B (GABAB) receptor agonist baclofen inhibits morphine sensitization by decreasing the dopamine level in rat nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Baclofen; Disease Models, Animal; Dopamine; Extracellular Space; GABA-B Receptor Agonists; Male; Microdialysis; Morphine; Morphine Dependence; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2012 |
Segmental disinhibition suppresses C-fiber inputs to the rat superficial medullary dorsal horn via the activation of GABAB receptors.
Topics: Action Potentials; Animals; Baclofen; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Male; Morphine; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Posterior Horn Cells; Rats; Rats, Inbred Strains; Receptors, GABA-B; Receptors, Glycine; Synaptic Transmission | 2013 |
Baclofen did not modify sexually dimorphic c-Fos expression during morphine withdrawal syndrome.
Topics: Animals; Baclofen; Female; GABA-B Receptor Agonists; Hippocampus; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Proto-Oncogene Proteins c-fos; Sex Factors; Substance Withdrawal Syndrome | 2013 |
Reversal of morphine analgesic tolerance by ethanol in the mouse.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; GABA Antagonists; Hypnotics and Sedatives; Immersion; Injections, Intraventricular; Male; Mice; Morphine; Pain Measurement; Receptors, GABA-A; Receptors, GABA-B | 2013 |
Effect of baclofen on morphine-induced conditioned place preference, extinction, and stress-induced reinstatement in chronically stressed mice.
Topics: Analysis of Variance; Animals; Baclofen; Chronic Disease; Conditioning, Operant; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; GABA Agonists; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Narcotics; Receptors, GABA-B; Reinforcement Schedule; Stress, Psychological | 2014 |
Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation.
Topics: Analgesics, Opioid; Animals; Baclofen; Behavior, Animal; Conditioning, Operant; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Hippocampus; Long-Term Potentiation; Male; Memory; Morphine; Muscimol; Nucleus Accumbens; Phenols; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2017 |
Baclofen prevents the elevated plus maze behavior and BDNF expression during naloxone precipitated morphine withdrawal in male and female mice.
Topics: Animals; Baclofen; Brain; Brain-Derived Neurotrophic Factor; Female; GABA-B Receptor Agonists; Male; Maze Learning; Mice; Morphine; Naloxone; Narcotic Antagonists; Sex Factors; Substance Withdrawal Syndrome | 2016 |
Identification of Drugs in Parenteral Pharmaceutical Preparations from a Quality Assurance and a Diversion Program by Direct Analysis in Real-Time AccuTOFTM-Mass Spectrometry (DART-MS).
Topics: Amides; Analgesics; Anesthetics; Baclofen; Bupivacaine; Caffeine; Chromatography, High Pressure Liquid; Clonidine; Dexamethasone; Ephedrine; Fentanyl; Heparin; Hydromorphone; Ketamine; Mass Spectrometry; Methadone; Midazolam; Morphine; Oxytocin; Parenteral Nutrition Solutions; Phenylephrine; Ropivacaine; Succinylcholine | 2016 |
Clinical Pearls in palliative medicine.
Topics: Adult; Advance Care Planning; Aged; Antiemetics; Baclofen; Benzodiazepines; Constipation; Depressive Disorder, Major; Dyspnea; Female; Hiccup; Humans; Male; Methylphenidate; Middle Aged; Morphinans; Morphine; Nausea; Olanzapine; Palliative Medicine; Polyethylene Glycols; Prochlorperazine; Pruritus; Sertraline; Terminal Care; Walkers | 2017 |
G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons.
Topics: Analgesics, Opioid; Animals; Baclofen; Calcium; Capsaicin; CHO Cells; Cricetulus; Electrophysiology; Female; Ganglia, Spinal; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Humans; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Pain; Pain Measurement; Phosphatidylinositols; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; TRPM Cation Channels | 2017 |
Repeated Administration of Baclofen Modulates TRPV-1 Channel Expression by PKC Pathway in Dorsal Root Ganglia of Spinal Cord in a Morphine Tolerance Model of Rats
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Protein Kinase C; Rats, Wistar; RNA, Messenger; Spinal Cord; TRPV Cation Channels | 2020 |
The indirect γ-aminobutyric acid (GABA) receptor agonist gabaculine-induced loss of the righting reflex may inhibit the descending analgesic pathway.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Baclofen; Cyclohexanecarboxylic Acids; Dexmedetomidine; GABA Agonists; Ganglia, Spinal; Male; Mice; Morphine; Muscimol; Neural Pathways; Neurons; Pain Measurement; Rats; Reflex, Righting; Signal Transduction; Spinal Cord; Substance P | 2020 |
Long-term intrathecal administration of morphine vs. baclofen: Differences in CSF glycoconjugate profiles using multiglycomics.
Topics: Analgesics, Opioid; Baclofen; Glycoconjugates; Humans; Injections, Spinal; Morphine | 2022 |