baclofen and guanosine 5'-o-(3-thiotriphosphate)

Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Baclofen; Calcium Channels; Cell Membrane; Cerebral Cortex; Dihydropyridines; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Immune Sera; Male; Neurons; Rats; Rats, Inbred Strains

Topics: Amitriptyline; Baclofen; Blood Platelets; Cell Membrane; Chlorpromazine; Dibucaine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Phenobarbital; Phosphatidic Acids; Phospholipids; Propranolol; rap GTP-Binding Proteins

Topics: Animals; Baclofen; Barium; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Chlorine; Dose-Response Relationship, Drug; Estrenes; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Mice; Mice, Inbred ICR; Muscimol; Pyrrolidinones; Receptors, GABA-A; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Type C Phospholipases

Topics: Animals; Baclofen; Electrophysiology; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Lampreys; Neural Inhibition; Neurons; Pertussis Toxin; Receptors, GABA-A; Spinal Cord; Synapses; Synaptic Transmission; Virulence Factors, Bordetella

Topics: Animals; Baclofen; Bicuculline; Calcium; Cattle; Cells, Cultured; Chromaffin System; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Pertussis Toxin; Receptors, GABA-A; Virulence Factors, Bordetella

Topics: Animals; Baclofen; Brain Chemistry; Calcium; Chloride Channels; Egtazic Acid; Electric Conductivity; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ion Channels; Membrane Potentials; Membrane Proteins; Oocytes; Pertussis Toxin; Potassium Channels; Receptors, GABA-A; RNA, Messenger; Virulence Factors, Bordetella; Xenopus

Topics: Acetylcholine; Animals; Baclofen; Calcium Channel Blockers; Electrophysiology; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Homovanillic Acid; Neurons, Afferent; omega-Conotoxins; Peptides, Cyclic; Rats; Rats, Inbred Strains

Topics: Animals; Baclofen; Calcium Channels; Culture Techniques; Electrophysiology; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Light; Neurons; Rats; Rats, Inbred Strains; Stereoisomerism

Topics: Animals; Baclofen; Calcium; Cells, Cultured; Drug Synergism; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channels; Membrane Potentials; Rats; Thionucleotides

Topics: Animals; Baclofen; Calcium; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hippocampus; Ion Channels; Phorbol 12,13-Dibutyrate; Phorbol Esters; Potassium; Rats; Receptors, GABA-A; Receptors, Serotonin; Serotonin; Spiperone; Thionucleotides

Topics: Action Potentials; Animals; Baclofen; Dopamine; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Ion Channels; Male; Muscimol; Neurons; Potassium; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, GABA-A; Substantia Nigra; Thionucleotides; Time Factors

Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Baclofen; Barium; Caffeine; Calcium Channels; Chlorides; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Ion Channels; Neurons; Rats; Thionucleotides

Topics: Animals; Baclofen; Brain; Calcium; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Mathematics; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thionucleotides

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Baclofen; Calcium Channels; Cells, Cultured; Cholera Toxin; Colforsin; Culture Techniques; Electrophysiology; Enzyme Activation; Guanine Nucleotides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Neurons, Afferent; Protein Kinase C; Rats; Thionucleotides; Type C Phospholipases

Topics: Animals; Baclofen; Electric Conductivity; Enzyme Activation; Evoked Potentials; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; Injections, Intraventricular; Male; Membrane Potentials; Neurons; Pertussis Toxin; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synapses; Thionucleotides; Virulence Factors, Bordetella

Topics: Animals; Axons; Baclofen; Calcium Channels; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Receptors, GABA-A; Retina; Retinal Ganglion Cells; Synapses; Thionucleotides; Urodela

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Baclofen; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Male; Membrane Potentials; Pertussis Toxin; Raphe Nuclei; Rats; Serotonin; Thionucleotides; Virulence Factors, Bordetella

Topics: Adenylate Cyclase Toxin; Animals; Baclofen; Brain; Electric Conductivity; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Isoxazoles; Membrane Potentials; Neural Inhibition; Neurons; Pertussis Toxin; Rats; Synapses; Thionucleotides; Time Factors; Virulence Factors, Bordetella

Topics: Animals; Baclofen; Carbachol; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Ion Channels; Membrane Potentials; Microelectrodes; Pyramidal Cells; Rats; Serotonin; Thionucleotides

Topics: Animals; Autoradiography; Baclofen; Benzoxazines; Brain; Cannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GABA-B Receptor Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Morpholines; Naloxone; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid, mu

Topics: Animals; Baclofen; Bicuculline; Cell Polarity; Cycloleucine; Down-Regulation; Electrophysiology; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Patch-Clamp Techniques; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Receptors, GABA; Receptors, Serotonin; Retina

Topics: Ammonium Chloride; Animals; Baclofen; Bradykinin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Cell Differentiation; Cell Line; Dihydropyridines; Electrophysiology; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Neurotransmitter Agents; Nicotinic Acids; omega-Conotoxin GVIA; Oxadiazoles; Peptides; Phenytoin; Rats; Tumor Cells, Cultured

Topics: Animals; Baclofen; Calcium; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Signal Transduction; Synaptosomes

Topics: Analgesics; Animals; Baclofen; Calcium Channel Blockers; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Neurons; Protein Kinase C; Rats; Rats, Sprague-Dawley

Topics: Animals; Baclofen; Calcium Channels; Electric Conductivity; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Mollusk Venoms; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Purkinje Cells; Rats; Receptors, GABA-A; Spider Venoms; Spinal Cord

Topics: Animals; Baclofen; Barium; Cesium; Chlorides; Electric Conductivity; Electrodes; Evoked Potentials; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Potassium Chloride; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-B

Topics: Animals; Baclofen; Calcium Channels; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Kinetics; Rats

Topics: Animals; Animals, Newborn; Baclofen; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; GABA Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Neurons; Neurotransmitter Agents; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Thalamic Nuclei

Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine

Topics: Animals; Baclofen; Chlorides; Cortical Spreading Depression; Dose-Response Relationship, Drug; Electric Conductivity; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Male; Membrane Potentials; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Serotonin; Synapses

Topics: Animals; Baclofen; Cadmium; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Geniculate Bodies; Guanosine 5'-O-(3-Thiotriphosphate); Neurons; Organophosphorus Compounds; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrodotoxin; Thalamus; Vestibulocochlear Nerve

Topics: Animals; Baclofen; Calcium Channels; Calcium Channels, L-Type; Cell Division; Cells, Cultured; Cellular Senescence; Fetus; GABA-B Receptor Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Neurons; Nimodipine; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rabbits; Rats; Rats, Sprague-Dawley; Tetrodotoxin

Topics: Animals; Baclofen; Calcium Channels, N-Type; Cells, Cultured; GABA Agonists; GABA Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Lampreys; Membrane Potentials; Neurons, Afferent; Organophosphorus Compounds; Receptors, GABA-B

Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine

Topics: Amino Acid Sequence; Animals; Baclofen; Calcium; Cerebral Cortex; CHO Cells; Cricetinae; GABA Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Receptors, GABA-B; Receptors, Metabotropic Glutamate; Xenopus

Topics: Adenylyl Cyclases; Animals; Baclofen; Brain; Brain Chemistry; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Female; GABA Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Presynaptic; Sodium Oxybate; Subcellular Fractions

Topics: Animals; Baclofen; Cells, Cultured; Drug Interactions; Electric Stimulation; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Long-Term Potentiation; Membrane Potentials; Neural Inhibition; Neurons; Rats

Topics: Amino Acids, Dicarboxylic; Animals; Baclofen; Chelating Agents; Cycloleucine; Egtazic Acid; Electrophysiology; Excitatory Amino Acid Antagonists; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Membrane Potentials; Neural Inhibition; Neuroprotective Agents; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Metabotropic Glutamate; Songbirds; Synapses; Tetraethylammonium; Tetrodotoxin; Thionucleotides

Topics: Amphetamine; Amphetamine-Related Disorders; Animals; Baclofen; Dopamine; Drug Administration Schedule; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Sulfur Radioisotopes

Topics: Age Factors; Animals; Baclofen; Calcium; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Magnesium; Male; Muscarinic Antagonists; Oxotremorine; Phosphinic Acids; Propanolamines; Rats; Receptors, GABA-B; RNA, Messenger; Spinal Cord; Sulfur Radioisotopes

Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Dopamine; Dose-Response Relationship, Drug; GABA-B Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Limbic System; Male; Rats; Rats, Inbred F344; Receptors, GABA-B; Subcellular Fractions; Substantia Nigra; Sulfur Radioisotopes; Synaptic Membranes; Ventral Tegmental Area

Topics: Animals; Baclofen; Biotransformation; Cattle; Dental Pulp; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Radiopharmaceuticals; Receptors, GABA-B; Receptors, Opioid; Statistics, Nonparametric; Sulfur Radioisotopes

Topics: Amphetamine; Animals; Antidepressive Agents; Baclofen; Behavior, Animal; Brain; Central Nervous System Stimulants; Drug Synergism; Guanosine 5'-O-(3-Thiotriphosphate); Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Restraint, Physical; Stress, Psychological; Tranylcypromine

Topics: Animals; Baclofen; Binding Sites; Formaldehyde; GABA Agonists; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Male; Pain Measurement; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; RNA, Messenger; Sulfur Radioisotopes

Topics: Animals; Animals, Newborn; Baclofen; Blotting, Northern; Blotting, Western; Cerebral Cortex; DNA Probes; Female; GABA Agonists; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Immunochemistry; In Situ Hybridization; Male; Pregnancy; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Sulfur Isotopes

Topics: Animals; Animals, Newborn; Baclofen; Barium; Drug Interactions; GABA Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Neural Conduction; Neurons; Olfactory Pathways; Oxotremorine; Patch-Clamp Techniques; Rats; Rats, Wistar; Time Factors

Topics: Allosteric Regulation; Animals; Baclofen; CHO Cells; Cricetinae; Cyclopentanes; GABA Agonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Kinetics; Oocytes; Potassium Channels; Pyrimidines; Radioligand Assay; Signal Transduction; Structure-Activity Relationship; Sulfur Radioisotopes; Xenopus

Topics: 4-Butyrolactone; Adjuvants, Anesthesia; Animals; Anticonvulsants; Autoradiography; Baclofen; Behavior, Animal; Benzocycloheptenes; Binding, Competitive; Body Weight; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Electroencephalography; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Inbred BALB C; Mice, Knockout; Motor Activity; Organophosphorus Compounds; Phenols; Radioligand Assay; Receptors, GABA-B; Sodium Oxybate; Time Factors

Topics: Androstadienes; Animals; Baclofen; Calcium; Calcium Channels, N-Type; Cell Membrane; Chelating Agents; Cytoskeleton; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Enzyme Inhibitors; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Membrane Potentials; Mice; Neurons; Oocytes; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Time Factors; Wortmannin; Xenopus; Xenopus laevis

Topics: Animals; Baclofen; Brain; Cell Membrane; GABA Agonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hydroxybutyrates; Male; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface

Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Baclofen; Desipramine; gamma-Aminobutyric Acid; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Male; Posterior Horn Cells; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Spinal Cord

Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Baclofen; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Organophosphorus Compounds; Protein Binding; Proteins; Radioligand Assay; Rats; RGS Proteins; Tritium

Topics: Animals; Autoradiography; Baclofen; Cocaine; Dopamine Uptake Inhibitors; Entorhinal Cortex; Enzyme Activation; Estrogens; Female; GABA Agonists; gamma-Aminobutyric Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Ovariectomy; Rats; Receptors, GABA-B; Ventral Tegmental Area

Topics: Animals; Baclofen; Barium; Bee Venoms; Dendrites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; GABA Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Neural Conduction; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyramidal Cells; Rats; Rats, Sprague-Dawley

Topics: Animals; Baclofen; Binding, Competitive; Brain; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; GABA-B Receptor Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred DBA; Morpholines; Organophosphorus Compounds; Receptors, GABA-B; Sulfur Radioisotopes; Tritium; Up-Regulation

Topics: Animals; Baclofen; Denervation; Disease Models, Animal; GABA Agonists; gamma-Aminobutyric Acid; Ganglia, Spinal; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Ligation; Male; Neural Inhibition; Neuralgia; Peripheral Nerve Injuries; Peripheral Nerves; Peripheral Nervous System Diseases; Posterior Horn Cells; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Synaptic Transmission; Up-Regulation

Topics: Alternative Splicing; Analgesics, Opioid; Animals; Baclofen; Calcium; Calcium Channels, N-Type; Cell Line; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Exons; GABA Agonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Membrane Potentials; Molecular Sequence Data; Neural Inhibition; Nociceptors; Patch-Clamp Techniques; Rats; Transfection

Topics: Allosteric Site; Animals; Baclofen; Brain; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Phenols; Phosphinic Acids; Propanolamines; Protein Binding; Radioligand Assay; Rats; Receptors, GABA-B; Signal Transduction

Topics: Adenosine; Analgesics; Analysis of Variance; Animals; Animals, Newborn; Baclofen; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Estrenes; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GABA Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Potentials; Neural Inhibition; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyramidal Cells; Pyrrolidinones; Rats; Somatosensory Cortex

Topics: Analgesics, Opioid; Animals; Baclofen; Biophysics; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Cells, Cultured; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; Ganglia, Spinal; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Lectins; Male; Membrane Potentials; omega-Conotoxin GVIA; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sensory Receptor Cells

Topics: Adenylyl Cyclases; Animals; Baclofen; Blotting, Western; Cell Line; Cell Membrane; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Rats; Rats, Wistar

Topics: Animals; Baclofen; Brain; Cannabinoid Receptor Modulators; GABA-A Receptor Agonists; GABA-B Receptor Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Knockout; Muscimol; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Receptors, GABA-B

Topics: Adaptation, Physiological; Animals; Baclofen; Behavior, Animal; Cell Membrane; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Protein alpha Subunits; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Male; Morphine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Time Factors

Topics: Animals; Autoradiography; Baclofen; Benzofurans; Brain; Brain Chemistry; GABA Agonists; GABA Modulators; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; In Vitro Techniques; Mice; Mice, Inbred C57BL; Phenols; Receptors, GABA-B; Sodium Oxybate

Topics: Adamantane; Allosteric Regulation; Animals; Baclofen; Binding Sites; GABA Modulators; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred DBA; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Thiophenes

Topics: Animals; Baclofen; Brain; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Human Growth Hormone; Male; Rats; Receptors, GABA-B; Recombinant Proteins; Sulfur Radioisotopes

Topics: Animals; Baclofen; Brain; Central Nervous System Depressants; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Ethanol; GABA-B Receptor Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Microdialysis; Motor Activity; Protein Binding; Sulfur Isotopes

Topics: Administration, Oral; Allosteric Regulation; Animals; Baclofen; Chemistry Techniques, Synthetic; Drug Design; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Immobility Response, Tonic; Mice; Microsomes, Liver; NIH 3T3 Cells; Pentobarbital; Rats; Receptors, GABA-B; Thiophenes

Topics: Acoustic Stimulation; Allosteric Regulation; Allosteric Site; Animals; Animals, Newborn; Anticonvulsants; Baclofen; Cyclopentanes; Drug Interactions; GABA Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred DBA; Morpholines; Motor Activity; Protein Binding; Pyrazoles; Pyrimidines; Seizures; Sulfur Isotopes

Topics: Allosteric Regulation; Baclofen; Benzofurans; Binding Sites; Cyclization; Cyclopentanes; Drug Evaluation, Preclinical; GABA Modulators; GABA-B Receptor Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Norbornanes; Protein Binding; Pyrimidines; Receptors, GABA-B; Structure-Activity Relationship