Compounds > baclofen

baclofen and (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one

baclofen has been researched along with (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.69)29.6817
2010's11 (84.62)24.3611
2020's1 (7.69)2.80

Authors

AuthorsStudies
Chester, JA; Colby, DA; Han, C; Hockerman, GH; Jarrard, RE; Jiang, X; Kim, EH; Kirchhoff, AM; Powers, MS; Salvador, TK; Salyer, AE1
Brown, KM; Colby, DA; Doerksen, RJ; Hockerman, GH; Roy, KK1
Huwyler, J; Knoflach, F; Kolb, Y; Kratzeisen, C; Malherbe, P; Marcuz, A; Masciadri, R; Nakagawa, T; Norcross, RD; Porter, RH; Prinssen, EP; Sleight, AJ; Spooren, W; Thomas, AW; Wettstein, JG; Zenner, MT1
Cheng, K; France, CP; Koek, W; Rice, KC2
Gannon, RL; Millan, MJ1
Advani, T; Burke, TF; Cheng, K; Hensler, JG; Koek, W; Rice, KC1
Cheng, K; Koek, W; Rice, KC1
Colombo, G; Corelli, F; Gessa, GL; Leite-Morris, KA; Maccioni, P; Malherbe, P; Mugnaini, C; Thomas, AW; Vargiolu, D1
Borisova, T; Dudarenko, M; Pozdnyakova, N1
Benke, D; Malherbe, P; Ralvenius, WT; Zemoura, K1
de Miguel, E; Hyytiä, P; Janhunen, SK; Kaskinoro, J; Korpi, ER; Kuokkanen, K; Lainiola, M; Linden, AM; Myllymäki, M; Paasikoski, N; Vekovischeva, O; Vesajoki, M1
Brizzi, A; Castelli, MP; Corelli, F; Mostallino, R; Mugnaini, C1

Reviews

1 review(s) available for baclofen and (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one

ArticleYear
Activation of the γ-Aminobutyric Acid Type B (GABA(B)) Receptor by Agonists and Positive Allosteric Modulators.
    Journal of medicinal chemistry, 2015, Aug-27, Volume: 58, Issue:16

    Topics: Animals; GABA Agonists; GABA Antagonists; GABA Modulators; Humans; Molecular Conformation; Receptors, GABA-B; Structure-Activity Relationship

2015

Other Studies

12 other study(ies) available for baclofen and (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one

ArticleYear
Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor.
    Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6

    Topics: Animals; Behavior, Animal; Female; GABA-B Receptor Agonists; Halogenation; Ketones; Male; Mice; Models, Molecular; Protein Conformation; Receptors, GABA-B

2013
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors.
    British journal of pharmacology, 2008, Volume: 154, Issue:4

    Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Baclofen; Benzofurans; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; GABA Agonists; GTP-Binding Protein gamma Subunits; Humans; Male; Mice; Mice, Inbred DBA; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-B; Reflex; Stereoisomerism

2008
GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1

    Topics: Animals; Baclofen; Benzofurans; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Agonists; GABA Antagonists; GABA-B Receptor Agonists; Hypothermia; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organophosphorus Compounds; Phenols; Sodium Oxybate

2010
Positive allosteric modulators at GABAB receptors exert intrinsic actions and enhance the influence of baclofen on light-induced phase shifts of hamster circadian activity rhythms.
    Pharmacology, biochemistry, and behavior, 2011, Volume: 99, Issue:4

    Topics: Animals; Baclofen; Benzofurans; Circadian Rhythm; Cricetinae; Cyclopentanes; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Agonists; GABA-B Receptor Antagonists; Light; Male; Mesocricetus; Morpholines; Motor Activity; Pyrimidines; Receptors, GABA-A

2011
GABAB receptor-positive modulators: brain region-dependent effects.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:1

    Topics: Animals; Autoradiography; Baclofen; Benzofurans; Brain; Brain Chemistry; GABA Agonists; GABA Modulators; Guanosine 5'-O-(3-Thiotriphosphate); Image Processing, Computer-Assisted; In Vitro Techniques; Mice; Mice, Inbred C57BL; Phenols; Receptors, GABA-B; Sodium Oxybate

2012
Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:2

    Topics: Animals; Baclofen; Benzofurans; Columbidae; Conditioning, Operant; Discrimination, Psychological; GABA Antagonists; GABA-B Receptor Agonists; Phenols; Phosphinic Acids; Receptors, GABA-B; Sodium Oxybate

2012
Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3

    Topics: Animals; Baclofen; Benzodiazepines; Benzofurans; Cocaine; Columbidae; Diazepam; Discrimination, Psychological; Ethanol; GABA-B Receptor Agonists; Illicit Drugs; Nicotine; Organophosphorus Compounds; Phenols; Sodium Oxybate

2013
Inhibition of alcohol self-administration by positive allosteric modulators of the GABAB receptor in rats: lack of tolerance and potentiation of baclofen.
    Psychopharmacology, 2015, Volume: 232, Issue:10

    Topics: Alcohol Drinking; Allosteric Regulation; Animals; Baclofen; Benzofurans; Cyclopentanes; Drug Synergism; Drug Tolerance; Ethanol; Male; Pyrimidines; Rats; Receptors, GABA-B; Self Administration

2015
New effects of GABAB receptor allosteric modulator rac-BHFF on ambient GABA, uptake/release, Em and synaptic vesicle acidification in nerve terminals.
    Neuroscience, 2015, Sep-24, Volume: 304

    Topics: Allosteric Regulation; Animals; Baclofen; Benzofurans; Cerebral Cortex; Dose-Response Relationship, Drug; Extracellular Space; GABA Agents; gamma-Aminobutyric Acid; Hippocampus; Male; Membrane Potentials; Protons; Rats, Wistar; Receptors, GABA-B; Synaptic Vesicles; Synaptosomes; Tritium

2015
The positive allosteric GABAB receptor modulator rac-BHFF enhances baclofen-mediated analgesia in neuropathic mice.
    Neuropharmacology, 2016, Volume: 108

    Topics: Allosteric Regulation; Analgesia; Animals; Baclofen; Benzofurans; Dose-Response Relationship, Drug; GABA Modulators; GABA-B Receptor Agonists; Male; Mice; Mice, Inbred C57BL; Neuralgia; Receptors, GABA-B; Sciatic Neuropathy

2016
GABA
    Addiction biology, 2019, Volume: 24, Issue:6

    Topics: Allosteric Regulation; Animals; Baclofen; Behavior, Animal; Benzofurans; Central Nervous System Depressants; CHO Cells; Cocaine; Cricetulus; Dopamine Uptake Inhibitors; Dopaminergic Neurons; Ethanol; GABA Modulators; GABA-B Receptor Agonists; Humans; Mice; Neuronal Plasticity; Quinazolinones; Rats; Receptors, GABA-B; Receptors, Glutamate; Reward; Self Administration; Ventral Tegmental Area

2019
Structure optimization of positive allosteric modulators of GABA
    Bioorganic & medicinal chemistry letters, 2020, 09-15, Volume: 30, Issue:18

    Topics: Allosteric Regulation; Baclofen; Benzofurans; Binding Sites; Cyclization; Cyclopentanes; Drug Evaluation, Preclinical; GABA Modulators; GABA-B Receptor Agonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Norbornanes; Protein Binding; Pyrimidines; Receptors, GABA-B; Structure-Activity Relationship

2020