b-807-27 and antimycin

b-807-27 has been researched along with antimycin* in 1 studies

Other Studies

1 other study(ies) available for b-807-27 and antimycin

Article	Year
Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts. Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3 We have investigated the contribution of peroxisomes and mitochondria to the beta-oxidation of palmitate (C16:0) and cerotate (C26:0) in intact human skin fibroblasts. The oxidation of both fatty acids was found to be inhibited by rotenone plus antimycin and cyanide, respectively, although to a different extent. When 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) was used to specifically block carnitine palmitoyltransferase I, it was found that palmitate beta-oxidation was inhibited almost completely whereas cerotate beta-oxidation was not affected. Since carnitine palmitoyltransferase is essential for the oxidation of fatty acids in mitochondria this result provides conclusive evidence that oxidation of very-long-chain fatty acids is initiated in peroxisomes and not in mitochondria. Topics: Antimycin A; Cells, Cultured; Epoxy Compounds; Fatty Acids; Fibroblasts; Humans; Hypoglycemic Agents; Kinetics; Microbodies; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Potassium Cyanide; Rotenone; Skin	1991

Article

Year

Conclusive evidence that very-long-chain fatty acids are oxidized exclusively in peroxisomes in human skin fibroblasts.

Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3

We have investigated the contribution of peroxisomes and mitochondria to the beta-oxidation of palmitate (C16:0) and cerotate (C26:0) in intact human skin fibroblasts. The oxidation of both fatty acids was found to be inhibited by rotenone plus antimycin and cyanide, respectively, although to a different extent. When 2-[5-(4-chlorophenyl)pentyl]-oxirane-2-carboxylate (POCA) was used to specifically block carnitine palmitoyltransferase I, it was found that palmitate beta-oxidation was inhibited almost completely whereas cerotate beta-oxidation was not affected. Since carnitine palmitoyltransferase is essential for the oxidation of fatty acids in mitochondria this result provides conclusive evidence that oxidation of very-long-chain fatty acids is initiated in peroxisomes and not in mitochondria.

Topics: Antimycin A; Cells, Cultured; Epoxy Compounds; Fatty Acids; Fibroblasts; Humans; Hypoglycemic Agents; Kinetics; Microbodies; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Potassium Cyanide; Rotenone; Skin

1991