Page last updated: 2024-09-04

b 669 and clofazimine

b 669 has been researched along with clofazimine in 16 studies

Compound Research Comparison

Studies
(b 669)
Trials
(b 669)
Recent Studies (post-2010)
(b 669)
Studies
(clofazimine)
Trials
(clofazimine)
Recent Studies (post-2010) (clofazimine)
16001,377129469

Protein Interaction Comparison

ProteinTaxonomyb 669 (IC50)clofazimine (IC50)
ATP-dependent translocase ABCB1Homo sapiens (human)0.9
CruzipainTrypanosoma cruzi6
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)3.2

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19902 (12.50)18.7374
1990's14 (87.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Conalty, ML; Morrison, NE; O'Sullivan, JF1
Levy, L1
Anderson, R; Van Rensburg, CE; Van Staden, AM1
Dooms, TG; Kuschke, RH; Wadee, AA1
Anderson, R; Jooné, GK; Myer, MS; O'Sullivan, JF; Van Rensburg, CE1
van Rensburg, CE; van Straten, A1
Anderson, R; Smit, MJ1
Anderson, R; Krajewska, MM1
Anderson, R; Krajewska, MM; O'Sullivan, JF1
Myer, MS; Van Rensburg, CE1
Anderson, R; Dooms, TG; Kuschke, RH; Wadee, AA1
Anderson, R; Prinsloo, Y; van der Walt, R; van Rensburg, CE1
Anderson, R; De Bruyn, EE; Steel, HC; Van Rensburg, EJ1
Anderson, R; Jooné, G; Myer, MS; O'Sullivan, JF; Van Rensburg, CE1
Anderson, R; Jooné, G; Van Rensburg, CE1
Anderson, R; Matlola, NM; Steel, HC1

Other Studies

16 other study(ies) available for b 669 and clofazimine

ArticleYear
Clofazimine analogues active against a clofazimine-resistant organism.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Animals; Cells, Cultured; Clofazimine; Drug Resistance, Microbial; Macrophages; Mice; Mycobacterium; Mycobacterium leprae; Structure-Activity Relationship

1988
Activity of four clofazimine analogues against Mycobacterium leprae.
    Leprosy review, 1981, Volume: 52, Issue:1

    Topics: Animals; Clofazimine; Mice; Mice, Inbred BALB C; Mycobacterium leprae

1981
The riminophenazine agents clofazimine and B669 inhibit the proliferation of cancer cell lines in vitro by phospholipase A2-mediated oxidative and nonoxidative mechanisms.
    Cancer research, 1993, Jan-15, Volume: 53, Issue:2

    Topics: Animals; Arachidonic Acid; Bleomycin; Cell Death; Cell Division; Cisplatin; Clofazimine; Cyclooxygenase Inhibitors; Cytotoxicity, Immunologic; Growth Inhibitors; Humans; In Vitro Techniques; L-Lactate Dehydrogenase; Lipoxygenase Inhibitors; Lysophosphatidylcholines; Methotrexate; Neutrophils; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Protein Kinase C; Tumor Cells, Cultured; Vitamin E

1993
The inhibitory effects of Mycobacterium tuberculosis on MHC class II expression by monocytes activated with riminophenazines and phagocyte stimulants.
    Clinical and experimental immunology, 1995, Volume: 100, Issue:3

    Topics: Antigens, Bacterial; Antigens, Fungal; Clofazimine; HLA-D Antigens; Humans; Immunosuppressive Agents; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Monocytes; Mycobacterium tuberculosis; Phagocytosis; Saccharomyces cerevisiae

1995
The riminophenazine agents clofazimine and B669 reverse acquired multidrug resistance in a human lung cancer cell line.
    Cancer letters, 1994, Sep-30, Volume: 85, Issue:1

    Topics: Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Small Cell; Cell Division; Clofazimine; Cyclosporine; Drug Interactions; Drug Resistance, Multiple; Humans; Lung Neoplasms; Tumor Cells, Cultured; Vinblastine

1994
An in-vitro investigation of the susceptibility of Enterococcus faecalis to clofazimine and B669.
    The Journal of antimicrobial chemotherapy, 1994, Volume: 33, Issue:2

    Topics: Anti-Bacterial Agents; Clofazimine; Enterococcus faecalis; Microbial Sensitivity Tests

1994
Clofazimine and B669 inhibit the proliferative responses and Na+, K(+)-adenosine triphosphatase activity of human lymphocytes by a lysophospholipid-dependent mechanism.
    Biochemical pharmacology, 1993, Dec-03, Volume: 46, Issue:11

    Topics: Anti-Infective Agents; Arachidonic Acid; Cell Division; Clofazimine; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lysophospholipase; Lysophospholipids; Phospholipases A; Sodium-Potassium-Exchanging ATPase; T-Lymphocytes; Tritium; Vitamin E

1993
An in vitro comparison of the effects of the prooxidative riminophenazines clofazimine and B669 on neutrophil phospholipase A2 activity and superoxide generation.
    The Journal of infectious diseases, 1993, Volume: 167, Issue:4

    Topics: Adult; Anti-Infective Agents; Arachidonic Acids; Clofazimine; Humans; In Vitro Techniques; Lipopolysaccharides; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Superoxides

1993
Effects of clofazimine analogues and tumor necrosis factor-alpha individually and in combination on human polymorphonuclear leukocyte functions in vitro.
    International journal of immunopharmacology, 1993, Volume: 15, Issue:2

    Topics: Adult; Cell Degranulation; Clofazimine; Drug Synergism; Humans; In Vitro Techniques; Iodine; Neutrophils; Peroxidase; Superoxides; Tumor Necrosis Factor-alpha

1993
Chemosensitizing interactions of clofazimine and B669 with human K562 erythroleukaemia cells with varying levels of expression of P-glycoprotein.
    Cancer letters, 1996, Jan-19, Volume: 99, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clofazimine; Drug Interactions; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Ethacrynic Acid; Flow Cytometry; Genistein; Humans; Isoflavones; Leukemia, Erythroblastic, Acute; Tritium; Tumor Cells, Cultured; Vinblastine

1996
The pro-oxidative riminophenazine B669 neutralizes the inhibitory effects of Mycobacterium tuberculosis on phagocyte antimicrobial activity.
    International journal of immunopharmacology, 1995, Volume: 17, Issue:10

    Topics: Anti-Bacterial Agents; Bacterial Proteins; Clofazimine; Humans; In Vitro Techniques; Monocytes; Mycobacterium tuberculosis; Neutrophils; Phagocytosis; Respiratory Burst

1995
Augmentative inhibition of lymphocyte proliferation by cyclosporin A combined with the riminophenazine compounds clofazimine and B669.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:9

    Topics: Adenosine Triphosphate; Adult; Arachidonic Acid; Clofazimine; Cyclosporine; Drug Synergism; Humans; Immunosuppressive Agents; Lymphocyte Activation; Lysophosphatidylcholines; Sodium-Potassium-Exchanging ATPase

1995
The riminophenazines, clofazimine and B669, inhibit potassium transport in gram-positive bacteria by a lysophospholipid-dependent mechanism.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:3

    Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Biological Transport; Clofazimine; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Lysophosphatidylcholines; Lysophospholipids; Mutation; Potassium; Potassium Radioisotopes; Rubidium Radioisotopes; Vitamin E

1996
Novel tetramethylpiperidine-substituted phenazines are potent inhibitors of P-glycoprotein activity in a multidrug resistant cancer cell line.
    Anti-cancer drugs, 1997, Volume: 8, Issue:7

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clofazimine; Drug Resistance, Multiple; Humans; Leukemia; Molecular Structure; Phenazines; Piperidines; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine

1997
Alpha-tocopherol antagonizes the multidrug-resistance-reversal activity of cyclosporin A, verapamil, GF120918, clofazimine and B669.
    Cancer letters, 1998, May-15, Volume: 127, Issue:1-2

    Topics: Acridines; Cell Death; Clofazimine; Cyclosporine; Drug Resistance, Multiple; Humans; Isoquinolines; Lung Neoplasms; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil; Vinblastine; Vitamin E

1998
Inhibition of potassium transport and growth of mycobacteria exposed to clofazimine and B669 is associated with a calcium-independent increase in microbial phospholipase A2 activity.
    The Journal of antimicrobial chemotherapy, 1999, Volume: 44, Issue:2

    Topics: Adenosine Triphosphate; Anti-Bacterial Agents; Biological Transport; Calcium; Clofazimine; Humans; Mycobacterium; Mycobacterium tuberculosis; Phospholipases A; Phospholipases A2; Potassium

1999