Compounds > b 4162
Page last updated: 2024-09-03

b 4162 and indomethacin

b 4162 has been researched along with indomethacin in 4 studies

Compound Research Comparison

Studies
(b 4162)		Trials
(b 4162)		Recent Studies (post-2010)
(b 4162)		Studies
(indomethacin)		Trials
(indomethacin)		Recent Studies (post-2010) (indomethacin)
501029,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyb 4162 (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ichihara, A; Kageyama, Y; Murakami, M; Naitoh, M; Nakamoto, H; Ohishi, A; Saruta, T; Suzuki, H1
Franco, R; Gavras, H; Gavras, I; Mulinari, R1
Chong, CK; Honrath, U; Sonnenberg, H; Veress, AT1
Berezin, M; Prior, T; Rangachari, PK1

Other Studies

4 other study(ies) available for b 4162 and indomethacin

ArticleYear
Depressor systems contribute to hypertension induced by glucocorticoid excess in dogs.
    Journal of hypertension, 1992, Volume: 10, Issue:6

    Topics: Animals; Blood Pressure; Bradykinin; Dexamethasone; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Glucocorticoids; Hypertension; Indomethacin; Kallikrein-Kinin System; Male; Prostaglandins; Time Factors

1992
Bradykinin antagonism and prostaglandins in blood pressure regulation.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 13, Issue:6 Pt 2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Bradykinin; Cyclooxygenase Inhibitors; Heart Rate; Indomethacin; Male; Prazosin; Prostaglandins; Rats; Rats, Inbred Strains

1989
Effect of bradykinin B2 receptor antagonist and indomethacin on natriuretic and hypotensive responses to atrial natriuretic factor.
    Canadian journal of physiology and pharmacology, 1994, Volume: 72, Issue:12

    Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Indomethacin; Male; Natriuresis; Prostaglandins; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2

1994
Effects of bradykinin on the canine proximal colon.
    Regulatory peptides, 1993, Jul-23, Volume: 46, Issue:3

    Topics: Amino Acid Sequence; Animals; Bradykinin; Colon; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Epithelium; Female; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Male; Molecular Sequence Data; Tetrodotoxin

1993