azuletil-sodium has been researched along with azulene* in 1 studies
1 other study(ies) available for azuletil-sodium and azulene
| Article | Year |
|---|---|
A ring expansion-annulation strategy for the synthesis of substituted azulenes. Preparation and Suzuki coupling reactions of 1-azulenyl triflates.
[structure: see text]. A new strategy for the synthesis of substituted azulenes is reported, based on the reaction of beta'-bromo-alpha-diazo ketones with rhodium carboxylates. The key transformation involves intramolecular addition of a rhodium carbenoid to an arene pi-bond, electrocyclic ring opening, beta-elimination, tautomerization, and trapping to produce 1-hydroxyazulene derivatives. The synthetic utility of the method is enhanced by the ability of the triflate derivatives to participate in Suzuki coupling reactions, as illustrated in a synthesis of the antiulcer drug egualen sodium (KT1-32). Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Azulenes; Benzene; Cycloheptanes; Humans; Ketones; Molecular Structure; Rhodium; Sesquiterpenes | 2001 |