azomycin has been researched along with sr 4554 in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aboagye, EO; Huxham, IM; Johnson, A; Lewis, AD; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Graham, MA; Kelson, AB; Lewis, AD; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Graham, MA; Kelson, AB; Lewis, AD; Ryan, KJ; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Graham, MA; Griffiths, JR; Horsman, MR; Kelson, AB; Lewis, AD; Maxwell, RJ; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Lewis, AD; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Griffiths, JR; Horsman, MR; Lewis, AD; Maxwell, RJ; Tracy, M; Workman, P | 1 |
| Aboagye, EO; Cannell, MB; Griffiths, JR; Judson, IR; Leach, MO; McSheehy, PM; Ojugo, AS; Robinson, SP | 1 |
| Aboagye, EO; Kelson, AB; Tracy, M; Workman, P | 1 |
| Busch, TM; Evans, SM; Hahn, SM; Koch, CJ | 1 |
| Grimshaw, R; Honess, DJ; Maxwell, RJ; Raynaud, F; Seddon, BM; Tozer, GM; Workman, P | 1 |
| Workman, P | 1 |
| Grimshaw, R; Halbert, G; Judson, I; Leach, MO; Payne, GS; Raynaud, F; Ruddle, R; Seddon, BM; Simmons, L; Tan, S; Turner, A; Workman, P | 1 |
| Seddon, BM; Workman, P | 1 |
| Campbell, MJ; Cross, K; Eaton, D; Halbert, G; Judson, I; Leach, MO; Lee, CP; McNamara, J; Oregioni, A; Payne, GS; Raynaud, FI; Ruddle, R; Seddon, B; Tan, S; Tracy, M; Workman, P | 1 |
4 review(s) available for azomycin and sr 4554
| Article | Year |
|---|---|
Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia
Topics: Animals; Cell Hypoxia; Humans; Magnetic Resonance Spectroscopy; Molecular Probes; Neoplasms; Nitroimidazoles; Tomography, Emission-Computed | 1998 |
Challenges of PK/PD measurements in modern drug development.
Topics: Antineoplastic Agents; Benzoquinones; Cell Hypoxia; Drug Design; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Molecular Chaperones; Nitroimidazoles; Rifabutin | 2002 |
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles | 2003 |
The role of functional and molecular imaging in cancer drug discovery and development.
Topics: Antineoplastic Agents; Benzoquinones; Diagnostic Imaging; HSP90 Heat-Shock Proteins; Humans; Hypoxia; Lactams, Macrocyclic; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Rifabutin; Technology, Pharmaceutical; Ultrasonography | 2003 |
2 trial(s) available for azomycin and sr 4554
| Article | Year |
|---|---|
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Topics: Adult; Aged; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Female; Fluorine Radioisotopes; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Maximum Tolerated Dose; Metabolic Clearance Rate; Middle Aged; Neoplasms; Nitroimidazoles | 2003 |
A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.
Topics: Adult; Aged; Aged, 80 and over; Cell Hypoxia; Female; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Young Adult | 2009 |
9 other study(ies) available for azomycin and sr 4554
| Article | Year |
|---|---|
The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.
Topics: Aerobiosis; Cell Hypoxia; Electron Spin Resonance Spectroscopy; Female; Humans; Image Processing, Computer-Assisted; Microscopy, Electron; Molecular Probes; Nitroimidazoles; Ovarian Neoplasms; Oxidation-Reduction; Subcellular Fractions; Tumor Cells, Cultured | 1995 |
Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma.
Topics: Animals; Calibration; Cell Hypoxia; Chromatography, High Pressure Liquid; Female; Indicators and Reagents; Mass Spectrometry; Mice; Mice, Inbred BALB C; Molecular Probes; Nitroimidazoles; Quality Control; Reproducibility of Results; Sensitivity and Specificity | 1995 |
The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.
Topics: Animals; Biological Availability; Brain; Cell Hypoxia; Female; Liver; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Molecular Probes; Neoplasm Transplantation; Nitroimidazoles; Tissue Distribution | 1996 |
Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Female; Fluorine; Hydralazine; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Reproducibility of Results | 1997 |
Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Male; Mice; Mice, Inbred BALB C; Molecular Probes; NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Oxidation-Reduction; Oxygen; Rats | 1997 |
The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.
Topics: Animals; Carcinoma; Cell Hypoxia; Fluorine Radioisotopes; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Molecular Probes; Nitroimidazoles; Oxygen | 1998 |
Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo.
Topics: Animals; Biological Transport; Carbon Dioxide; Fibrosarcoma; Fluorouracil; Hydrogen-Ion Concentration; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Nuclear Magnetic Resonance, Biomolecular; Oxygen; Sarcoma, Experimental | 1998 |
Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide ].
Topics: Animals; Cell Separation; Fibrosarcoma; Flow Cytometry; Mice; Microscopy, Fluorescence; Molecular Probes; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nitroimidazoles; Oxygen Consumption; Photochemotherapy; Tumor Cells, Cultured | 2000 |
Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.
Topics: Animals; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Female; Fluorine Radioisotopes; Hypoxia; Magnetic Resonance Spectroscopy; Mice; Mice, SCID; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Polarography; Rats; Tissue Distribution | 2002 |