Compounds > azomycin
Page last updated: 2024-08-21

azomycin and posaconazole

azomycin has been researched along with posaconazole in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (10.34)29.6817
2010's20 (68.97)24.3611
2020's6 (20.69)2.80

Authors

AuthorsStudies
Brener, Z; Loebenberg, D; Martins-Filho, O; Molina, J; Romanha, AJ; Urbina, JA1
Alves, RO; Ferraz, ML; Gazzinelli, RT; Romanha, AJ; Urbina, JA2
Araújo-Jorge, TC; Calvet, CM; de Castro, SL; Molina, JT; Olivieri, BP; Pereira, MC; Urbina, JA1
Clayton, J1
Le Loup, G; Lescure, FX; Pialoux, G1
Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL1
Carlier, Y; Cencig, S; Coltel, N; Truyens, C1
Aldasoro, E; Cortes-Lletget, C; Espinosa, G; Gállego, M; Gascon, J; Muñoz, J; Oliveira, I; Pinazo, MJ; Posada, Ede J1
Aiub, CA; Araújo, JS; Batista, Dda G; Batista, MM; Britto, C; da Silva, CF; da Silva, PB; de Souza, EM; Hargrove, TY; Kim, K; Lepesheva, GI; Lionel, J; Pavão, BP; Soeiro, Mde N; Sulikowski, G; Waterman, MR1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; Martins, TA; Mazzeti, AL; Ribeiro, I; Talvani, A; Urbina, JA1
Blanco-Grau, A; Cabezos, J; Gómez i Prat, J; Molina, I; Pahissa, A; Pou, D; Roure, S; Salvador, F; Sánchez-Montalvá, A; Serre, N; Sulleiro, E; Treviño, B; Valerio, L; Vidal, X1
Albajar-Viñas, P; Dias, JC1
Chatelain, E; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Taylor, MC1
Glynne, R; Groessl, T; Khare, S; Liu, X; Molteni, V; Rivera, I; Stinson, M; Supek, F; Tuntland, T; Wen, B; Yeh, V1
Botero, A; Keatley, S; Peacock, C; Thompson, RC1
Apt, W; Beloscar, J; Bonilla, LR; Colombo, H; Cuneo, C; Del Carmen Bangher, M; Echeverria, LE; Gao, P; Gascon, J; Mallagray, M; McCarthy, M; Meeks, B; Milesi, R; Molina, I; Morillo, CA; Perez-Molina, JA; Sosa-Estani, S; Waskin, H; Wei, B; Wyss, F; Yusuf, S1
Bern, C1
de La Roca Soares, MF; de Medeiros Vieira, ACQ; Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Soares Sobrinho, JL1
Urbina, JA1
Campos, MC; Clark, TG; Francisco, AF; Kelly, JM; Lewis, MD; Pain, A; Phelan, J; Taylor, MC1
Alonso-Vega, C; Alves, F; Curto, MA; de la Barra, A; Flevaud, L; García, L; Gascón, J; Irazu, L; Molina, I; Ortiz, L; Parrado, R; Ramírez, JC; Ribeiro, I; Rodríguez, M; Schijman, AG; Sulleiro, E; Torrico, F; Villarroel, S1
Figueirêdo, CBM; Lee, PI; Nadvorny, D; Rolim Neto, PJ; Schver, GCRM; Soares Sobrinho, JL; Soares, MFR; Vieira, ACQM1
Díaz, ML; Echeverría, LE; Eduardo Nieto, J; González, CI; Hernandez, JCM; López-Romero, LA; Morillo, CA; Ochoa, SAG; Rivera, JD; Rojas, LZ; Suárez, EU1
Au, HYA; Bhattacharyya, T; Chatelain, E; Franco, CH; Freitas-Junior, LH; Giardini, MA; Le, H; Madeira, RP; Miles, MA; Moraes, CB; Pascoalino, BS; Romera, LMD; Schenkman, S; Torrecilhas, AC; Warhurst, DC1
Braissant, O; Fesser, AF; Kaiser, M; Kelly, JM; Mäser, P; Olmo, F1
Bardach, A; Barreira, F; Ciapponi, A; Gascón, J; Molina, I; Morillo, C; Perelli, L; Prado, N; Riarte, A; Ribeiro, I; Sosa-Estani, S; Torrico, F; Villar, JC1
Calvet, CM; Hirata, K; McKerrow, JH; Silva, TA; Siqueira-Neto, JL; Suzuki, B; Thomas, D1
Acosta, N; Bobadilla, C; Escobar, P; Fernández, I; López, E; Ramírez, A; Yaluff, G1

Reviews

3 review(s) available for azomycin and posaconazole

ArticleYear
Update in treatment of Chagas disease.
    Current opinion in infectious diseases, 2011, Volume: 24, Issue:5

    Topics: Chagas Disease; Chronic Disease; Humans; Immune Tolerance; Immunocompromised Host; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2011
Immunosuppression and Chagas disease: a management challenge.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:1

    Topics: Adult; Antiprotozoal Agents; Chagas Disease; Female; Humans; Immunocompromised Host; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Opportunistic Infections; Triazoles; Trypanosoma cruzi

2013
Fixed vs adjusted-dose benznidazole for adults with chronic Chagas disease without cardiomyopathy: A systematic review and meta-analysis.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:8

    Topics: Adult; Cardiomyopathies; Chagas Disease; Databases, Factual; Humans; Nifurtimox; Nitroimidazoles; Patient Safety; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Trypanosoma cruzi

2020

Trials

2 trial(s) available for azomycin and posaconazole

ArticleYear
Randomized trial of posaconazole and benznidazole for chronic Chagas' disease.
    The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20

    Topics: Adult; Chagas Disease; Chronic Disease; DNA, Protozoan; Female; Humans; Intention to Treat Analysis; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Transaminases; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2014
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial.
    Journal of the American College of Cardiology, 2017, Feb-28, Volume: 69, Issue:8

    Topics: Administration, Oral; Adult; Chagas Disease; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Single-Blind Method; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2017

Other Studies

24 other study(ies) available for azomycin and posaconazole

ArticleYear
Activities of the triazole derivative SCH 56592 (posaconazole) against drug-resistant strains of the protozoan parasite Trypanosoma (Schizotrypanum) cruzi in immunocompetent and immunosuppressed murine hosts.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:1

    Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Drug Resistance; Female; Immunocompetence; Immunosuppression Therapy; Mice; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2000
The Anti-Trypanosoma cruzi activity of posaconazole in a murine model of acute Chagas' disease is less dependent on gamma interferon than that of benznidazole.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:4

    Topics: Animals; Chagas Disease; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2007
Absence of CD4+ T lymphocytes, CD8+ T lymphocytes, or B lymphocytes has different effects on the efficacy of posaconazole and benznidazole in treatment of experimental acute Trypanosoma cruzi infection.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1

    Topics: Animals; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Disease; Male; Mice; Mice, Knockout; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2009
A comparative study of posaconazole and benznidazole in the prevention of heart damage and promotion of trypanocidal immune response in a murine model of Chagas disease.
    International journal of antimicrobial agents, 2010, Volume: 36, Issue:1

    Topics: Animals; Antiprotozoal Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Heart; Humans; Mice; Myocardium; Nitroimidazoles; Survival Analysis; Triazoles; Trypanosoma cruzi

2010
Chagas disease: pushing through the pipeline.
    Nature, 2010, Jun-24, Volume: 465, Issue:7301

    Topics: Adult; Animals; Chagas Disease; Child; Chronic Disease; Clinical Trials as Topic; Drug Evaluation, Preclinical; Female; Humans; Infant, Newborn; Lupus Erythematosus, Systemic; Molecular Targeted Therapy; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi; Young Adult

2010
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2012
Evaluation of benznidazole treatment combined with nifurtimox, posaconazole or AmBisome® in mice infected with Trypanosoma cruzi strains.
    International journal of antimicrobial agents, 2012, Volume: 40, Issue:6

    Topics: Amphotericin B; Animals; Chagas Disease; Disease Models, Animal; DNA, Protozoan; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C; Nifurtimox; Nitroimidazoles; Parasite Load; Parasitemia; Real-Time Polymerase Chain Reaction; Treatment Outcome; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2012
In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Animals; Chagas Disease; Drug Resistance; Endoplasmic Reticulum; Golgi Apparatus; Imidazoles; Male; Mice; Microscopy, Electron, Transmission; Nitroimidazoles; Oxadiazoles; Protozoan Proteins; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2013
Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.
    PLoS neglected tropical diseases, 2013, Volume: 7, Issue:8

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Parasitemia; Treatment Outcome; Triazoles; Trypanosoma cruzi

2013
Advancing the treatment for Chagas' disease.
    The New England journal of medicine, 2014, May-15, Volume: 370, Issue:20

    Topics: Chagas Disease; Female; Humans; Male; Nitroimidazoles; Triazoles; Trypanocidal Agents

2014
Limited Ability of Posaconazole To Cure both Acute and Chronic Trypanosoma cruzi Infections Revealed by Highly Sensitive In Vivo Imaging.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:8

    Topics: Animals; Antifungal Agents; Chagas Disease; Chronic Disease; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Mice, SCID; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2015
Antitrypanosomal Treatment with Benznidazole Is Superior to Posaconazole Regimens in Mouse Models of Chagas Disease.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:10

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Animals; Chagas Disease; Clinical Trials, Phase II as Topic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart; Humans; Immunosuppression Therapy; Mice; NIH 3T3 Cells; Nitroimidazoles; Parasitemia; Recurrence; Sterol 14-Demethylase; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2015
In vitro drug susceptibility of two strains of the wildlife trypanosome, Trypanosoma copemani: A comparison with Trypanosoma cruzi.
    International journal for parasitology. Drugs and drug resistance, 2017, Volume: 7, Issue:1

    Topics: Animals; Animals, Wild; Australia; Cell Line; Drug Discovery; High-Throughput Screening Assays; Inhibitory Concentration 50; Melarsoprol; Nitroimidazoles; Phosphorylcholine; Potoroidae; Pyrimidines; Triazoles; Trypanocidal Agents; Trypanosoma; Trypanosoma cruzi

2017
A New Epoch in Antitrypanosomal Treatment for Chagas Disease.
    Journal of the American College of Cardiology, 2017, 02-28, Volume: 69, Issue:8

    Topics: Animals; Chagas Disease; Nitroimidazoles; Parasites; Triazoles

2017
Enhancement of dissolution rate through eutectic mixture and solid solution of posaconazole and benznidazole.
    International journal of pharmaceutics, 2017, Jun-15, Volume: 525, Issue:1

    Topics: Drug Combinations; Drug Compounding; Nitroimidazoles; Solubility; Triazoles

2017
Pharmacodynamics and Follow-Up Period in the Treatment of Human Trypanosoma Cruzi Infections With Posaconazole.
    Journal of the American College of Cardiology, 2017, 07-11, Volume: 70, Issue:2

    Topics: Animals; Chagas Disease; Follow-Up Studies; Humans; Nitroimidazoles; Parasites; Triazoles

2017
Genome-wide mutagenesis and multi-drug resistance in American trypanosomes induced by the front-line drug benznidazole.
    Scientific reports, 2017, 10-31, Volume: 7, Issue:1

    Topics: Animals; Chagas Disease; Disease Models, Animal; Drug Resistance, Multiple; Female; Genome, Protozoan; Mice, SCID; Mutagenesis; Mutagens; Mutation; Nitroimidazoles; Sequence Analysis, DNA; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2017
First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Chagas Disease; Humans; Monitoring, Physiologic; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Triazoles; Trypanocidal Agents

2017
Enhanced delivery of fixed-dose combination of synergistic antichagasic agents posaconazole-benznidazole based on amorphous solid dispersions.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, Jul-01, Volume: 119

    Topics: Biological Availability; Chagas Disease; Drug Carriers; Drug Combinations; Drug Liberation; Drug Synergism; Models, Molecular; Nitroimidazoles; Povidone; Pyrrolidines; Triazoles; Trypanocidal Agents; Vinyl Compounds

2018
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas.
    Revista da Sociedade Brasileira de Medicina Tropical, 2020, Volume: 53

    Topics: Acute Disease; Animals; Chagas Disease; Disease Models, Animal; Disease Progression; DNA, Protozoan; Drug Therapy, Combination; Nitroimidazoles; Parasite Load; Parasitemia; Rats; Rats, Wistar; Triazoles; Trypanocidal Agents

2020
Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.
    International journal for parasitology. Drugs and drug resistance, 2020, Volume: 13

    Topics: 14-alpha Demethylase Inhibitors; Animals; Cell Line; Chagas Disease; Drug Resistance, Multiple; Genes, Protozoan; Mutation; Nitroimidazoles; Sterol 14-Demethylase; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
Non-invasive monitoring of drug action: A new live in vitro assay design for Chagas' disease drug discovery.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:7

    Topics: Chagas Disease; Drug Discovery; Humans; Nitroimidazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
Long term follow-up of Trypanosoma cruzi infection and Chagas disease manifestations in mice treated with benznidazole or posaconazole.
    PLoS neglected tropical diseases, 2020, Volume: 14, Issue:9

    Topics: Administration, Oral; Animals; Chagas Disease; Disease Models, Animal; Follow-Up Studies; Male; Mice, Inbred C57BL; Nitroimidazoles; Polymerase Chain Reaction; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020
In vitro susceptibility to benznidazole, nifurtimox and posaconazole of Trypanosoma cruzi isolates from Paraguay
    Biomedica : revista del Instituto Nacional de Salud, 2020, 12-02, Volume: 40, Issue:4

    Topics: Analysis of Variance; Genotype; Lethal Dose 50; Nifurtimox; Nitroimidazoles; Paraguay; Phenotype; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2020