azomycin has been researched along with pimonidazole in 365 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 58 (15.89) | 18.7374 |
| 1990's | 31 (8.49) | 18.2507 |
| 2000's | 140 (38.36) | 29.6817 |
| 2010's | 126 (34.52) | 24.3611 |
| 2020's | 10 (2.74) | 2.80 |
| Authors | Studies |
|---|---|
| Chaplin, DJ; Horsman, MR | 1 |
| Bleehen, NM; Maughan, TS; Newman, HF; Stenning, S; Ward, R; Workman, P | 1 |
| Brown, JM; Cribbs, R; Hirst, VK; Luu, YH; Stone, HB | 1 |
| Guichard, ME; Lespinasse, F; Taghian, A | 1 |
| Watts, ME; Woodcock, M | 1 |
| Dennis, MF; Roberts, IJ; Watts, ME | 1 |
| Bleehen, NM; Newman, HF; Smithen, CE; Ward, R; Workman, P | 1 |
| Bleehen, NM; Maughan, TS; Newman, HF; Ward, R; Workman, P | 1 |
| Mori, T; Murayama, C | 1 |
| Butler, SA; Cobb, LM; Nolan, J | 1 |
| Wagner, W | 1 |
| Dische, S | 2 |
| Workman, P | 1 |
| DeGraff, WG; Gamson, J; Mitchell, JB; Russo, A | 1 |
| Bonnay, M; Guichard, M; Lespinasse, F; Malaise, EP; Thomas, C | 1 |
| Hall, EJ; Hei, TK | 1 |
| Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ | 1 |
| Bleehen, NM; Maughan, TS; Newman, HF; Workman, P | 1 |
| Bennett, MH; Dische, S; Orchard, R; Stratford, MR; Wardman, P | 1 |
| Canal, P; Laurent, F; Soula, G | 1 |
| George, KC; Pelzer, T; Streffer, C | 1 |
| Roberts, IJ; Watts, ME; Woodcock, M | 1 |
| Bleehen, NM; Walton, MI; Workman, P | 4 |
| Luscher, G; Streffer, C; Tamulevicius, P | 1 |
| Bleehen, NM; Newman, HF; Ward, R; Workman, P | 2 |
| Hofer, KG; Hofer, MG; Lakkis, M | 1 |
| Adams, GE; Stratford, IJ | 1 |
| Bleehen, NM; Newman, HF; Workman, P | 2 |
| Hill, RP | 1 |
| Durand, RE; Harrison, I; Palcic, B; Skarsgard, LD | 1 |
| Lam, KN; Luu, YH; Stone, HB | 1 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Orchard, RA; Saunders, MI; Stratford, MR | 1 |
| Minchinton, AI; Stratford, MR | 1 |
| Ward, R; Workman, P | 1 |
| Dennis, MF; Watts, ME; Woodcock, M | 1 |
| Abe, M; Fushiki, M; Nishidai, T; Ono, K; Sasai, K; Shibamoto, Y; Takahashi, M; Tsutsui, K | 1 |
| Freedman, LS; Workman, P | 1 |
| Bleehen, NM; Honess, DJ; Ward, R; Wasserman, TH; Workman, P | 1 |
| Wasserman, TH | 1 |
| Berenbaum, MC | 1 |
| Brown, JM | 1 |
| Abe, M; Hori, H; Inayama, S; Kano, E; Ono, K; Shibamoto, Y; Shibata, T; Takahashi, M | 1 |
| Coleman, CN | 1 |
| Benard, P; Canal, P; Laurent, F; Soula, G | 1 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Saunders, MI; Stratford, MR; Wardman, P | 1 |
| Bleehen, NM; Des Rochers, C; Dische, S; Dunphy, EP; Lenox-Smith, I; Newman, HF; Saunders, MI; Smithen, CE; Workman, P | 1 |
| Geard, CR; Hall, EJ; Hei, TK; Osmak, RS | 1 |
| Dennis, MF; Stratford, MR; Wardman, P; Watts, ME | 1 |
| Jones, NR; Watts, ME | 1 |
| Bleehen, NM; Roberts, JT; Walton, MI; Workman, P | 2 |
| Ahmed, I; Jenkins, TC; Stratford, IJ | 1 |
| Smith, RA | 1 |
| Hinchliffe, M; McNally, NJ | 1 |
| Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
| Denekamp, J; Fowler, JF; Williams, MV | 1 |
| Anderson, PJ; Bennett, MH; Dische, S; Minchinton, A; Saunders, MI; Stratford, MR; Tothill, M | 1 |
| Allen, JG; Dische, S; Lenox-Smith, I; Malcolm, SL; Saunders, MI | 1 |
| Denekamp, J; Fowler, JF; Hill, SA; Minchinton, AI; Stratford, MR | 1 |
| Gibson, P; Sheldon, PW | 1 |
| Groves, JK; Lee, A; Malcolm, SL | 1 |
| Denekamp, J; Michael, BD; Minchinton, AI; Smithen, CE; Stewart, FA; Stratford, MR; Terry, NH | 1 |
| Allen, JG; Bishop, A; Dische, S; Fermont, D; Lenox-Smith, I; Malcolm, SL; Saunders, MI | 1 |
| Arteel, GE; Raleigh, JA; Thurman, RG; Yates, JM | 1 |
| el Gamoussi, R; Guichard, M; Stratford, IJ | 1 |
| el Gamoussi, R; Guichard, M; Prade, M; Stratford, IJ; Threadgill, MD | 1 |
| Cowan, DS; Hicks, KO; Wilson, WR | 1 |
| Chou, SC; Flood, PM; Raleigh, JA | 1 |
| Arteel, GE; Iimuro, Y; Raleigh, JA; Thurman, RG; Yin, M | 1 |
| Calkins, DP; Kennedy, AS; Novotny, DB; Perez, GM; Raleigh, JA; Thrall, DE; Varia, MA | 1 |
| Azuma, C; Raleigh, JA; Thrall, DE | 1 |
| Arteel, GE; Raleigh, JA; Thurman, RG | 1 |
| Durand, RE; Raleigh, JA | 1 |
| Ballenger, CA; Calkins-Adams, DP; Fowler, WC; Novotny, DB; Raleigh, JA; Rinker, LH; Varia, MA; Weissler, MC | 1 |
| Arteel, GE; Connor, HD; Frankenberg, MV; Mason, RP; Raleigh, JA; Stachlewitz, RF; Thurman, RG; Yin, M; Zhong, Z | 1 |
| Calkins-Adams, DP; Fowler, WC; Kennedy, AS; Novotny, DB; Raleigh, JA; Rinker, LH; Varia, MA | 1 |
| Arteel, GE; Chou, SC; Horsman, MR; Raleigh, JA | 1 |
| Bunzendahl, H; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Arteel, GE; Bunzendahl, H; Connor, HD; Mason, RP; Raleigh, JA; Schemmer, P; Thurman, RG | 1 |
| Corpechot, C; Galy, B; Housset, C; Poupon, R; Raleigh, J; Rosmorduc, O; Sebbagh, N; Wendum, D | 1 |
| Måseide, K; Rofstad, EK | 1 |
| Bakker, JH; Bernsen, HJ; Boerman, RH; Peters, JP; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Dewhirst, MW; Greenberg, CS; Haroon, ZA; Raleigh, JA | 1 |
| Ballenger, CA; Calkins-Adams, DP; Chou, SC; Novotny, DB; Raleigh, JA; Varia, MA | 1 |
| Begg, AC; Geboes, K; Haustermans, K; Hofland, I; Raleigh, J; Van de Pavert, L; Varia, M | 1 |
| Bussink, J; de Wilde, PC; Kaanders, JH; Marres, HA; Raleigh, JA; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI | 1 |
| Lehnert, S | 1 |
| Bernsen, HJ; Jeuken, JW; Peters, H; Raleigh, JA; Rijken, PF; van der Kogel, AJ; Wesseling, P | 1 |
| Bernsen, HJ; Hodgkiss, RJ; Peters, JP; Raleigh, JA; Rijken, PF; van der Kogel, AJ | 1 |
| Bussink, J; Kaanders, JH; Strik, AM; van Der Kogel, AJ; Vojnovic, B | 1 |
| Bussink, J; Kaanders, JH; Strik, AM; van der Kogel, AJ | 1 |
| Aquino-Parsons, C; Durand, RE; Luo, C; Olive, PL; Raleigh, JA | 1 |
| Thurman, RG | 1 |
| O'Hara, JA; Paulsen, KD; Pogue, BW; Swartz, HM; Wilmot, CM | 1 |
| Bussink, J; Denekamp, J; Ljungkvist, AS; Raleigh, JA; Rijken, PF; Van Der Kogel, AJ | 1 |
| Beasley, NJ; Harris, AL; Maxwell, PH; Pastorek, J; Pugh, CW; Ratcliffe, PJ; Sibtain, A; Talks, KL; Turley, H; Turner, KJ; Watson, PH; Wilson, GD; Wykoff, CC | 1 |
| Bae, SK; Chung, HY; Jeong, CH; Kim, KW; Koo, SY; Lee, YM; Raleigh, JA; Son, MJ; Song, HS; Yoo, MA | 1 |
| Bono, EL; Chou, SC; Raleigh, JA; Thrall, DE; Varia, MA | 1 |
| Chou, SC; Davidson, SE; Havsteen, H; Hunter, R; Lindegaard, JC; Loncaster, J; Nordsmark, M; Overgaard, J; Raleigh, JA; Varia, M; West, C | 1 |
| Albina, JE; Henry, WL; Louis, CA; Mastrofrancesco, B; Reichner, JS; Vessella, JA | 1 |
| Aquino-Parsons, C; Lerman, MI; Liao, SY; MacPhail, SH; Olive, PL; Raleigh, JA; Stanbridge, EJ | 1 |
| Barbu, V; Chignard, N; Corpechot, C; Housset, C; Poupon, R; Rosmorduc, O; Wendum, D | 1 |
| Aquino-Parsons, C; Banáth, JP; Olive, PL | 1 |
| Balm, A; Begg, AC; Blommestijn, G; Delaere, P; Hofland, I; Janssen, H; Raleigh, JA; Sciot, R; Sprong, D; Van Velthuyzen, L; Varia, M | 1 |
| Banáth, JP; Luo, CM; Olive, PL | 1 |
| Braun, RD; Dewhirst, MW; Greer, PK; Gwinn, WM; Hale, LP | 1 |
| Bonn, D | 1 |
| Galappathi, K; Graff, BA; Mathiesen, B; Nilsen, K; Rasmussen, H; Rofstad, EK | 1 |
| Peters, JP; Rijken, PF; Van der Kogel, AJ | 1 |
| Balm, AJ; Begg, AC; Haustermans, KM; Hoebers, FJ; Hoefnagel, CA; Janssen, HL; Nunn, AD; Olmos, AV; Sprong, D | 1 |
| Basile, DP; Donohoe, DL; Mattson, DL; Roethe, K | 1 |
| Balm, AJ; Begg, AC; Blijweert, E; Blommestijn, G; Delaere, P; Haustermans, KM; Hoebers, FJ; Hofland, I; Janssen, HL; Raleigh, JA; Sciot, R; Semenza, GL; Sprong, D; van Velthuysen, ML; Varia, MA | 1 |
| Bennewith, KL; Durand, RE; Raleigh, JA | 1 |
| Bussink, J; de Wilde, PC; Kaanders, JH; Ljungkvist, AS; Marres, HA; Pop, LA; Raleigh, JA; van den Hoogen, FJ; van der Kogel, AJ; Wijffels, KI | 1 |
| Airley, RE; Davidson, SE; Harris, AL; Hunter, RD; Loncaster, J; Raleigh, JA; Stratford, IJ; West, CM | 1 |
| Bussink, J; Kaanders, JH; van der Kogel, AJ | 2 |
| Aquino-Parsons, C; Chou, SC; Davidson, SE; Havsteen, H; Hunter, R; Ladekarl, M; Lindegaard, JC; Loncaster, J; Nordsmark, M; Overgaard, J; Raleigh, JA; Varia, M; West, C | 1 |
| Décorps, M; Farion, R; Peters, JP; Rémy, C; Rijken, PF; Van der Kogel, AJ; Van der Sanden, BP; Zoula, S | 1 |
| Begg, AC | 1 |
| Brown, JM; Vordermark, D | 1 |
| Bachmann, S; Eckardt, KU; Frei, U; Griethe, W; Gruber, G; Rosenberger, C; Wiesener, M | 1 |
| Arteel, GE; McClain, CJ; McKim, SE; Raleigh, JA; Uesugi, T | 1 |
| Azuma, Y; Chou, SC; Lininger, RA; Murphy, BJ; Raleigh, JA; Varia, MA | 1 |
| Bassnett, S; McNulty, R | 1 |
| Blomgren, B; Danielsson, BR; Dillner, B; Johansson, A; Sköld, AC | 1 |
| Frischer, JS; Holash, J; Huang, J; Kadenhe-Chiwishe, A; Kandel, JJ; Kim, ES; Lee, A; New, T; Pollyea, DA; Serur, A; Yamashiro, DJ; Yancopoulos, GD; Yokoi, A | 1 |
| Balm, AJ; Begg, AC; Goethals, L; Haustermans, KM; Hoebers, FJ; Janssen, HL; Sprong, D; Stratford, IJ; Williams, KJ | 1 |
| Mechetner, E; Samoszuk, MK; Walter, J | 1 |
| Büchler, MW; Büchler, P; Friess, H; Hines, OJ; Lavey, RS; Reber, HA; Tomlinson, J | 1 |
| Daley, FM; Hoskin, PJ; Saunders, MI; Sibtain, A; Wilson, GD | 1 |
| Bussink, J; Heerschap, A; Lok, J; Punt, CJ; van Der Kogel, AJ; van Laarhoven, HW | 1 |
| Braun, RD; Brizel, DM; Cárdenas-Navia, LI; Dewhirst, MW; Secomb, TW; Yu, D | 1 |
| Bennewith, KL; Durand, RE | 1 |
| Bormans, G; Dubois, L; Dupont, P; Flamen, P; Haustermans, K; Landuyt, W; Mortelmans, L; Verbeken, E; Vermaelen, P | 1 |
| Sanders, PW; Wang, PX | 1 |
| Davidson, SE; Harris, AL; Hunter, RD; Hutchison, GJ; Loncaster, JA; Price, PM; Roberts, SA; Stratford, IJ; Valentine, HR; West, CM | 1 |
| Amin, K; Arcasoy, MO; Chou, SC; Haroon, ZA; Raleigh, JA; Varia, M | 1 |
| Bachmann, S; Eckardt, KU; Frei, U; Goldfarb, M; Griethe, W; Heyman, SN; Reinke, P; Rosen, S; Rosenberger, C; Shina, A | 1 |
| Burgman, P; Burnazi, E; Cai, S; Finn, RD; Humm, JL; Lewis, JS; Ling, CC; O'Donoghue, JA; Pugachev, A; Ruan, S; Smith-Jones, P; Welch, MJ; Wen, B; Zanzonico, P | 1 |
| Campa, J; Carlin, S; Humm, JL; Larson, SM; Ling, CC; Pugachev, A; Ruan, S | 1 |
| Begg, AC; Bussink, J; Kaanders, JH; Ljungkvist, AS; Raleigh, JA; Rijken, PF; van der Kogel, AJ | 1 |
| Doege, K; Heine, S; Jelkmann, W; Jensen, I; Metzen, E | 1 |
| Asosingh, K; De Raeve, H; de Ridder, M; Storme, GA; Van Camp, B; Van Riet, I; Vanderkerken, K; Willems, A | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Peters, JP; Rijken, PF; Troost, EG; van der Kogel, AJ; van Eerd, J | 1 |
| Baumann, M; Eicheler, W; Hessel, F; Hölscher, T; Krause, M; Petersen, C; Rosner, A; Thames, HD; Yaromina, A; Zips, D | 1 |
| Hofer, SO; Keramidaris, E; Knight, KR; Mitchell, GM; Morrison, WA; Palmer, J; Penington, AJ; RomeoMeeuw, R | 1 |
| Aquino-Parsons, C; Olive, P; Sobhanifar, S; Stanbridge, EJ | 1 |
| Hoogsteen, IJ; Kaanders, JH; Marres, HA; Peeters, WJ; Rijken, PF; van den Hoogen, FJ; van der Kogel, AJ | 1 |
| Angus, PW; Burrell, LM; Cooper, ME; Lew, RA; Paizis, G; Schembri, JM; Shaw, T; Smith, AI; Tikellis, C; Warner, FJ; Zuilli, A | 1 |
| de Geus-Oei, LF; Heerschap, A; Kaanders, JH; Krabbe, PF; Lok, J; Oyen, WJ; Punt, CJ; Rijpkema, M; Ruers, T; van der Kogel, AJ; van Laarhoven, HW; Wiering, B | 1 |
| Heerschap, A; Kaanders, JH; Lok, J; Peeters, WJ; Punt, CJ; Rijken, PF; Ruers, TJ; van der Kogel, AJ; van Laarhoven, HW; Wiering, B | 1 |
| Céspedes, C; Villanueva, S; Vio, CP | 1 |
| Chou, SC; Ji, X; Kleiter, MM; Lee, DY; Malarkey, DE; Raleigh, JA; Thrall, DE | 1 |
| Aquino-Parsons, C; Banath, JP; Durand, RE; Jankovic, B; MacPhail, SH; Olive, PL; Raleigh, JA; Stanbridge, EJ | 1 |
| Backes, W; Boterberg, T; Bouckenooghe, I; Ceelen, W; De Visschere, M; Demetter, P; Pattyn, P; Peeters, M; Smeets, P; Van Damme, N | 1 |
| Bentzen, SM; Carnell, DM; Daley, FM; Hoskin, PJ; Saunders, MI; Smith, RE | 1 |
| Buttrick, PM; Geenen, DL; Goldspink, PH; Hansen, J; McKinney, RD; Yuzhakova, M; Zampino, M | 1 |
| Begg, AC; De Schutter, H; Debucquoy, A; Ectors, N; Geboes, K; Goethals, L; Haustermans, KM; McBride, WH; Penninckx, F; Perneel, C | 1 |
| Bernhardt, W; Eckardt, KU; Frei, U; Heyman, SN; Rosen, S; Rosenberger, C; Shina, A; Wiesener, MS | 1 |
| Aquino-Parsons, C; Chou, SC; Davidson, SE; Gebski, V; Havsteen, H; Hunter, R; Lindegaard, JC; Loncaster, J; Nordsmark, M; Overgaard, J; Raleigh, JA; West, C | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, M; Troost, EG; van der Kogel, AJ | 1 |
| Balm, A; Barbé, B; Begg, AC; De Schutter, H; Gregoire, V; Haustermans, K; Mahy, P; Nuyts, S; Spaepen, M; Vander Poorten, V | 1 |
| Aquino-Parsons, C; Durand, RE | 1 |
| Alber, M; Eschmann, SM; Holzner, F; Paulsen, F; Thorwarth, D | 1 |
| Baumann, M; Eicheler, W; Haase, M; Krause, M; Mueller-Klieser, W; Petersen, C; Quennet, V; Raleigh, JA; Rosner, A; Thames, HD; Walenta, S; Yaromina, A; Zips, D | 1 |
| Aly, S; Bange, FC; Brandau, S; Ehlers, S; Keller, C; Malm, S; Malzan, A; Wagner, K | 1 |
| Curtis, TM; de Gooyer, TE; Gardiner, TA; Humphries, P; Simpson, DA; Stevenson, KA; Stitt, AW | 1 |
| Donadieu, E; Lavieille, JP; Magnan, J; Riva, C | 1 |
| Burgman, P; Chen, Q; Diaz-Gonzalez, JA; Li, XF; Ling, CC; Russell, J; Shin, KH | 1 |
| Beygui, RE; Brown, DA; Dunn, JC; Laks, H; MacLellan, WR; Wu, BM | 1 |
| Aramori, I; Furuichi, Y; Ishiye, M; Matsuoka, N; Mutoh, S; Noto, T; Yanagihara, T | 1 |
| Chrisostomidis, C; Dontas, I; Frangoulis, M; Georgiou, P; Kavantzas, N; Kostakis, A; Papadopoulos, O; Perrea, D | 1 |
| Deveze, A; Donadieu, E; Hamdi, W; Lavieille, JP; Lucciano, M; Magnan, J; Riva, C | 1 |
| Down, JD; Mauch, P; Parmar, K; Sackstein, R; Vergilio, JA | 1 |
| Barbier, V; Helwani, F; Hendy, J; Lévesque, JP; Nilsson, SK; Nowlan, B; Williams, B; Winkler, IG | 1 |
| Deng, X; Ganey, PE; Lu, J; Luyendyk, JP; Malle, E; Roth, RA; Zou, W | 1 |
| Aly, S; Andries, K; Basaraba, RJ; Cantarero, L; Ehlers, S; Hoff, D; Lenaerts, AJ; Orme, IM | 1 |
| Eykyn, TR; Gabellieri, C; Leach, MO | 1 |
| Bentzen, SM; Carnell, DM; Collins, DJ; d'Arcy, JA; Daley, FM; Hoskin, PJ; Padhani, AP; Saunders, MI; Smith, RE; Stirling, JJ; Taylor, NJ | 1 |
| Echevarría, M; López-Barneo, J; Muñoz-Cabello, AM; Sánchez-Silva, R; Toledo-Aral, JJ | 1 |
| Ohno, N; Ohno, S; Saitoh, S; Terada, N | 1 |
| Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ; Wijffels, KI | 1 |
| Cheluvappa, R; Cogger, VC; Hilmer, SN; Kwun, SY; LE Couteur, DG | 1 |
| Le, QT | 1 |
| Ahn, JH; Chung, JW; Kang, HH; Kim, YJ | 1 |
| Nerurkar, A; Pearson, A; Peckitt, C; Reis-Filho, JS; Sharp, G; Steele, D; Westbury, CB; Yarnold, JR | 1 |
| Abassi, Z; Eckardt, KU; Goldfarb, M; Heyman, SN; Khamaisi, M; Rosen, S; Rosenberger, C; Shilo, V; Shina, A; Weksler-Zangen, S; Zibertrest, F | 1 |
| Bosetto, MC; Degrossoli, A; Giorgio, S; Lima, CB | 1 |
| Chastagner, P; Fouyssac, F; Karcher, G; Pinel, S; Plenat, F; Poussier, S; Scigliano, S | 1 |
| Baumann, M; Bergmann, R; Beuthien-Baumann, B; Brüchner, K; Dörfler, A; Eicheler, W; Hessel, F; Krause, M; Menegakis, A; Schütze, C; van den Hoff, J; Wüllrich, K; Yaromina, A; Zhou, X; Zips, D | 1 |
| Bergh, A; Rudolfsson, SH | 1 |
| Busk, M; Bussink, J; Horsman, MR; Jakobsen, S; Keiding, S; Overgaard, J; van der Kogel, AJ | 1 |
| Allen, SS; Barry, CE; Carrillo, J; Cho, SN; Eum, SY; Flynn, JL; Gonzales, J; Klein, E; Lee, EG; Lin, PL; Manjunatha, U; McMurray, DN; Park, SK; Raleigh, JA; Ray, SM; Taylor, K; Via, LE | 1 |
| Bijnens, AP; Cleutjens, JP; Corvol, P; Daemen, MJ; Gasc, JM; Groeneweg, M; Kisters, N; Sluimer, JC; Sollewijn Gelpke, MD; van den Akker, LH; van Wanroij, JL; Wouters, BG | 1 |
| Mayr, M; Sidibe, A; Zampetaki, A | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, ME; Troost, EG; van der Kogel, AJ | 1 |
| Koch, CJ | 1 |
| Humm, JL; Li, GC; Li, XF; Ling, CC; Russell, J; Sun, X; Urano, M; Xing, L | 1 |
| Brader, P; Carlin, S; Chun, YS; Fong, Y; Hricak, H; Ling, CC; Riedl, CC; Singh, P; Wen, B; Woo, Y; Zanzonico, PB | 1 |
| Busk, M; Horsman, MR; Overgaard, J | 1 |
| Hirota, M; Kikuta, K; Masamune, A; Satoh, K; Shimosegawa, T; Watanabe, T | 1 |
| Gilbert, RE; Kelly, DJ; Langham, RG; Tiauw, V; Wiggins, KJ; Zhang, Y | 1 |
| Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M; Zhang, J | 1 |
| Galappathi, K; Gulliksrud, K; Mathiesen, B; Rofstad, EK; Vestvik, IK | 1 |
| de Wilde, PC; Hoogsteen, IJ; Kaanders, JH; Lok, J; Marres, HA; Rijken, PF; van der Kogel, AJ; Wijffels, KI | 1 |
| Castellano, I; Charles-Edwards, E; Clarke, P; Fisher, C; Harrington, K; Leach, M; Mears, D; Newbold, K; Nutting, C; Rhys-Evans, P; Sohaib, A | 1 |
| Cui, P; Dai, M; Han, J; Li, H; Liu, Q; Xiu, R; Yu, M | 1 |
| Al-Shabrawey, M; Bartoli, M; Behzadian, MA; Caldwell, RB; Caldwell, RW; El-Remessy, AB; Istanboli, M; Labazi, M; Marcus, DM | 1 |
| Bach, A; Bürgers, HF; Dittgen, T; Gassler, N; Krüger, C; Kuschinsky, W; Maurer, MH; Sabouri, F; Schelshorn, DW; Schneider, A; Weber, D | 1 |
| Heyman, SN; Paliege, A; Rosen, S; Rosenberger, C | 1 |
| Ackerstaff, E; Carlin, S; Cho, H; Humm, JL; Koutcher, JA; Ling, CC; Lupu, ME; O'Donoghue, J; Rizwan, A; Wang, Y; Zanzonico, PB | 1 |
| Burke, SA; Carlin, S; Ling, CC; Russell, J; Wen, B; Yang, KM | 1 |
| Fujibayashi, Y; Fujieda, S; Furukawa, T; Kobayashi, M; Kudo, T; Mori, T; Oh, M; Tanaka, T | 1 |
| Chen, CL; Cheng, YF; Goto, S; Hsu, LW; Huang, CJ; Jawan, B; Kao, YH; Lin, YC; Nakano, T; Pan, MC; Sun, CK; Tai, MH; Wang, CS | 1 |
| Boutrid, H; Cebulla, CM; Feuer, WJ; Jockovich, ME; Lampidis, TJ; Murray, TG; Piña, Y | 1 |
| Baumann, M; Eckardt, A; Eicheler, W; Schuetze, C; Thames, H; Yaromina, A; Zips, D | 1 |
| Hoogsteen, IJ; Kaanders, JH; Lok, J; Marres, HA; Rijken, PF; Takes, RP; van der Kogel, AJ | 1 |
| Cho, H; Koutcher, JA; Li, XF; Ling, CC; Lupu, ME; Russell, J; Yang, KM | 1 |
| Busk, M; Bussink, J; Hansen, KV; Horsman, MR; Jakobsen, S; Overgaard, J; van der Kogel, A | 1 |
| Koch, CJ; Otto, CM; Robinson, MA; Tuttle, SW | 1 |
| Baumann, M; Meyer, S; Mueller-Klieser, W; Quennet, V; Shakirin, G; Walenta, S; Yaromina, A; Zips, D | 1 |
| Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Russell, J; Suehiro, M; Sun, X; Zhang, M | 1 |
| Möller, A; Young, RJ | 1 |
| Aihara, K; Akaike, M; Fukuhara, Y; Gonzalez, FJ; Ishizawa, K; Izawa-Ishizawa, Y; Kanbara, T; Kitagawa, T; Kurobe, H; Lei, Y; Ono, S; Ripen, AM; Takahama, Y; Tamaki, T; Tomita, S; Ueki, M; Ueno, M; Urata, M; Yoshizumi, M | 1 |
| McPhail, LD; Robinson, SP | 1 |
| Bengtsson, E; Blomgren, B; Danielsson, BR; Danielsson, C; Johansson, A; Khan, KM; Kultima, K; Nilsson, MF; Sköld, AC; Webster, WS; Wilson, J | 1 |
| Cheng, HL; Dai, W; Huang, RQ; Liu, Y; Shi, JX; Wu, Y; Zhao, XD; Zhuang, Z | 1 |
| Gaustad, JV; Rofstad, EK; Simonsen, TG | 1 |
| Dorogin, A; Lye, SJ; Shynlova, O | 1 |
| Humm, JL; Li, XF; Ling, CC; Ma, Y; O'Donoghue, JA; Sun, X | 1 |
| Chung, H; Khwarg, SI; Kim, YJ; Moon, JW; Yu, HG | 1 |
| Bazin, JE; Canis, M; D'Arpiany, F; Jardon, K; Mage, G; Maleysson, E; Matsuzaki, S | 1 |
| Baumann, M; Flentje, M; Jakob, PM; Melkus, G; Mörchel, P; Yaromina, A; Zips, D | 1 |
| Boerman, OC; Bussink, J; Franssen, GM; Hoeben, BA; Kaanders, JH; Oosterwijk, E; Oyen, WJ; Rijken, PF; Troost, EG; van Dongen, GA | 1 |
| Baumann, M; Dörfler, A; Eicheler, W; Hering, S; Leichtner, T; Thames, H; Yaromina, A; Zhou, X; Zips, D | 1 |
| An, H; Engenhart-Cabillic, R; Eul, BG; Fokas, E; Hänze, J; Heverhagen, JT; Kamlah, F; Keil, B; Lang, N; Rose, F | 1 |
| Baumann, M; Beuthien-Baumann, B; Bussink, J; Eicheler, W; Krause, M; Rijken, P; Santiago, A; van der Kogel, AJ; Yaromina, A | 1 |
| Boutrid, H; Celdran, M; Feuer, W; Hernandez, E; Houston, SK; Lampidis, TJ; Murray, TG; Piña, Y; Shi, W | 1 |
| Babaev, AA; Golubiatnikov, GY; Ivanova, IP; Kamensky, VA; Maslennikova, AV; Orlova, AG; Plekhanov, VI; Prianikova, TI; Shakhova, NM; Snopova, LB; Turchin, IV | 1 |
| Kashino, G; Kinashi, Y; Liu, Y; Masunaga, S; Nagasawa, H; Ono, K; Sakurai, Y; Suzuki, M; Tanaka, H | 1 |
| Gorodkin, R; Herrick, AL; Jeziorska, M; Stratford, IJ | 1 |
| Batlle, D; Cabray, J; Halter, S; Li, LP; Prasad, P; Ye, M | 1 |
| Cecic, IK; Erler, JT; Felsher, D; Giaccia, AJ; Graves, EE; Le, QT; Sayles, L; Sweet-Cordero, A; Tran, PT; Vilalta, M | 1 |
| Chaudhuri, S; Hennings, L; Hinson, JA; James, LP; Letzig, L; McCullough, SS; Simpson, PM | 1 |
| De Rooster, H; Dierckx, R; Ducatelle, R; Loomans, S; Mees, G; Pauwels, P; Peremans, K; Van Damme, N; Van de Wiele, C; Van Goethem, B; Vangestel, C | 1 |
| Beauduy, JL; Dornfeld, K; Gessert, CE; Knowles, DM; McDonald, BL; McNaney, DD; Renier, CM; Urias, RE; Widell, SL | 1 |
| Forsback, S; Heinonen, SE; Knuuti, J; Laine, VJ; Roivainen, A; Saraste, A; Saukko, P; Silvola, JM; Ylä-Herttuala, S | 1 |
| Astner, ST; Bayer, C; Maftei, CA; Shi, K; Vaupel, P | 1 |
| Baumann, M; Boeke, S; Kroeber, T; Meinzer, A; Thames, H; Yaromina, A; Zips, D | 1 |
| Cha, HJ; Cho, MK; Jo, JO; Kang, YJ; Ock, MS; Yu, HS | 1 |
| Betts, G; Bonington, SC; Buckley, DL; Donaldson, SB; Homer, JJ; Kershaw, LE; Slevin, NJ; Valentine, H; West, CM | 1 |
| Bussink, J; Kaanders, JH; Lok, J; Rademakers, SE; van der Kogel, AJ | 1 |
| Alblas, J; Dhert, WJ; Fedorovich, NE; Gawlitta, D; Kuipers, E | 1 |
| Chen, FH; Chiang, CS; Fu, SY; Hong, JH; Jung, SM; Lee, CC; Tsai, CS; Wang, CC; Wen, CJ | 1 |
| Bifani, P; Dartois, V; Heng, Y; Hervé, M; Kiass, M; Mathys, V; Seah, PG; Siew, JY; Singhal, A; Tay, HC | 1 |
| Egeland, TA; Gaustad, JV; Gulliksrud, K; Mathiesen, B; Rofstad, EK | 1 |
| Busk, M; Horsman, MR; Jakobsen, S; Mueller-Klieser, W; Overgaard, J; Steiniche, T; Walenta, S | 1 |
| Carlsson, PO; Olerud, J; Olsson, R; Pettersson, U | 1 |
| Carlsson, PO; Olsson, R | 1 |
| Fujii, H; Hiraoka, M; Kizaka-Kondoh, S; Kudo, T; Miyano, A; Mutou, Y; Ogawa, K; Ono, M; Saji, H; Ueda, M; Umeda, IO | 1 |
| Combes, V; Grau, GE; Hempel, C; Hunt, NH; Kurtzhals, JA | 1 |
| Bussink, J; Dubois, LJ; Janssen, MH; Kolb, HC; Lambin, P; Lieuwes, NG; Ollers, MC; Peeters, WJ; van der Kogel, A; van Dongen, GA; Walsh, JC; Windhorst, AD | 1 |
| Hagtvet, E; Olsen, DR; Røe, K | 1 |
| Bali, S; Bhutta, MF; Brown, SD; Cheeseman, MT; Hilton, H; Hough, TA; Parker, A; Pathak, P; Potter, PK; Purnell, T; Romero, MR; Tyrer, HE; Vizor, L; Vowell, K; Wells, S; Williams, D | 1 |
| Ellingsen, C; Galappathi, K; Mathiesen, B; Ovrebø, KM; Rofstad, EK | 1 |
| Baker, LC; Boult, JK; Burrell, JS; Halliday, J; Jamin, Y; Robinson, SP; Ryan, AJ; Walker-Samuel, S; Waterton, JC | 1 |
| Griffin, RJ; Koonce, NA; Przybyla, BD; Shafirstein, G; Webber, JS | 1 |
| Ellingsen, C; Galappathi, K; Ovrebø, KM; Rofstad, EK | 1 |
| Bussink, J; Hoogsteen, IJ; Kaanders, JH; Lok, J; Marres, HA; Rijken, PF; van den Hoogen, FJ | 1 |
| Barber, PR; Bell, A; Burke, M; Daley, FM; Finch, J; Goh, V; Hoskin, PJ; Kozarski, R; Mandeville, HC; Ng, QS; Pierce, G; Townsend, ER; Vojnovic, B | 1 |
| Busk, M; Bussink, J; Engelholm, SA; Hansen, AE; Jørgensen, JT; Kjær, A; Kristensen, AT; McEvoy, FJ; van der Kogel, AJ | 1 |
| Civelek, AC; Huang, T; Jiang, H; Li, J; Li, XF; Ng, CK; Postel, GC; Shen, B | 1 |
| Bartlett, R; Carlin, S; Humm, JL; McCall, KC; Reese, M | 1 |
| Fujii, H; Inoue, K; Kizaka-Kondoh, S; Moriyama, N; Mutou, Y; Saji, H; Ueda, M; Umeda, IO; Yamaguchi, M | 1 |
| Begg, A; Debucquoy, A; Devos, E; Haustermans, K; Penninckx, F; Sagaert, X; Verstraete, M | 1 |
| Kageyama, K; Kato, S; Kimura, M; Miwa, N; Tanaka, H | 1 |
| Barbier, EL; Bouchet, A; Christen, T; Le Duc, G; Lemasson, B; Maisin, C; Rémy, C; Serduc, R | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Waaijer, SJ; Wheeler, DL | 1 |
| Baumann, M; Böke, S; Helbig, L; Koi, L; Sriramareddy, SN; Thames, HD; Yaromina, A; Zips, D | 1 |
| Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M | 1 |
| Kondo, N; Maruhashi, A; Masunaga, S; Narabayashi, M; Ono, K; Sakurai, Y; Suzuki, M; Tanaka, H | 1 |
| Broggini-Tenzer, A; Hug, D; Orlowski, K; Pruschy, M; Rohrer Bley, C; Soltermann, A; Vuong, V; Zimmermann, M | 1 |
| Hirayama, R; Kondo, N; Maruhashi, A; Masunaga, S; Matsumoto, Y; Narabayashi, M; Ono, K; Sakurai, Y; Suzuki, M; Tanaka, H; Uzawa, A | 1 |
| Hanzawa, H; Hatano, T; Kuge, Y; Kuno, N; Nishijima, K; Sakamoto, T; Tamaki, N; Zhao, S; Zhao, Y | 1 |
| Bachmann, S; Dietrich, A; Kaminski, H; Mathia, S; Mrowka, R; Mutig, K; Paliege, A; Rosenberger, C | 1 |
| Kertscho, H; Lauscher, P; Meier, J; Rosenberger, P; Schmidt, O; Zacharowski, K; Zimmermann, R | 1 |
| Aminuddin, A; Fujisaka, S; Goda, N; Ikutani, M; Mahmood, A; Nagai, Y; Takatsu, K; Takikawa, A; Tobe, K; Tsuneyama, K; Usui, I | 1 |
| Ababneh, DH; Oakes, DJ; Power, CA; Ritchie, HE; Webster, WS | 1 |
| Hansen-Schwartz, J; Hasseldam, H; Hou, J; Johansen, FF; Munkholm, N | 1 |
| Canty, KJ; Harley, B; Lu, J; Mahoney, JE; Nombela-Arrieta, C; Park, SY; Pivarnik, G; Protopopov, A; Silberstein, LE; Winkel, B | 1 |
| Bussink, J; De Bree, R; Doornaert, PA; Hoogsteen, IJ; Kaanders, JH; Langendijk, JA; Oosterwijk, E; Rademakers, SE; Rijken, PF; Takes, R; Terhaard, CH; van den Ende, P; van der Kogel, AJ | 1 |
| Baumann, G; Liebl, DJ; Theus, MH; Travieso, L | 1 |
| Ashcroft, M; Baker, LC; Boult, JK; Burrell, JS; Gilmour, LD; Griffiths, JR; Howe, FA; Jamin, Y; Raleigh, JA; Robinson, SP; van der Kogel, AJ; Walker-Samuel, S | 1 |
| Cao, H; Chen, X; Chen, Y; Fan, J; Fu, S; Lin, S; Ren, P; Su, Z; Sun, X; Wu, J; Yang, B; Yang, L; Zhang, Y; Zhou, J; Zhou, Y; Zou, X | 1 |
| Dalloul, A | 1 |
| Busk, M; Horsman, MR; Iversen, AB; Jakobsen, S; Ji, X; Lee, DY; Mortensen, LS; Nordsmark, M; Overgaard, J; Raleigh, JR | 1 |
| Cunningham-Bussel, A; Nathan, CF; Zhang, T | 1 |
| Ellingsen, C; Galappathi, K; Hompland, T; Mathiesen, B; Rofstad, EK | 1 |
| Enjoji, M; Kato, M; Kotoh, K; Masaki, Y; Miyazaki, M; Nakamuta, M; Takayanagi, R; Tanaka, K; Tanaka, M | 1 |
| Baumann, M; Brüchner, K; Gurtner, K; Helbig, L; Hess-Stumpp, H; Koi, L; Pruschy, M; Unterschemmann, K; Yaromina, A; Zips, D | 1 |
| Abdelkader, A; Eppel, GA; Evans, RG; Ho, J; Ow, CP; Rajapakse, NW; Schlaich, MP | 1 |
| Adochite, RC; Andreev, OA; Carlin, SD; Guerrieri, RA; Lewis, JS; Moshnikova, A; Reshetnyak, YK | 1 |
| Adachi, T; Gu, N; Joo, E; Kondoh, T; Li, S; Matsunaga, T; Tsuda, K; Yamazaki, H; Yasuda, K | 1 |
| Capozzi, ME; Craft, JR; Evans, SM; Jayagopal, A; Kim, K; Moore, CE; Sulikowski, GA; Uddin, MI | 1 |
| de Groot, H; Fandrey, J; Funk, K; Pütter, C; Scheerer, N; Verhaegh, R | 1 |
| Axcrona, K; Frikstad, KM; Hole, KH; Julin, CH; Lie, AK; Lyng, H; Ragnum, HB; Seierstad, T; Vlatkovic, L | 1 |
| Saggar, JK; Tannock, IF | 1 |
| Andreeff, M; Benito, J; Borthakur, G; Bueso-Ramos, C; Cortes, J; Coveler, A; Daver, N; Estey, EH; Faderl, S; Feliu, J; Gu, Y; Gutheil, JC; Jabbour, E; Kadia, T; Kantarjian, H; Konoplev, S; Konopleva, M; Kornblau, S; Lu, H; Melink, TJ; Nguyen, HQ; Pemmaraju, N; Ravandi, F; Thall, PF; Thomas, D; Wei, C; Wilson, WR; Yi, CA | 1 |
| Duan, X; Li, J; Li, XF; Ma, Y; Postel, GC; Wang, F; Wang, X; Yin, X; Zhang, G; Zheng, H | 1 |
| Araujo, AP; Giorgio, S | 1 |
| Gao, M; Huang, D; Jiang, C; Lou, B; Lu, X; Ni, Y; Peng, F; Ren, K; Wang, X; Yang, A; Yao, N; Zhang, J | 1 |
| Bhatnagar, R; Bhuyan, S; Das, B; Garhyan, J; Kalita, D; Pulu, I | 1 |
| Chae, JR; Cho, A; Cho, YL; Chung, KY; Kang, WJ; Kim, JY; Lee, JW; Park, SY | 1 |
| Galoforo, S; Grills, IS; Kane, JL; Krueger, SA; Marples, B; Wilson, GD; Wobb, J | 1 |
| Bollineni, VR; Bruine de Bruin, L; de Bock, GH; Halmos, GB; Langendijk, JA; Pruim, J; Schuuring, E; Slagter-Menkema, L; Steenbakkers, RJ; van der Laan, BF; van der Wal, JE; van Hemel, BM; Wachters, JE | 1 |
| Dings, RP; Griffin, RJ; Hardee, ME; Jamshidi-Parsian, A; Koonce, NA; Levy, J; Raleigh, JA; Sharma, S; Vang, KB | 1 |
| Dhani, NC; Gallinger, S; Hedley, DW; Hill, RP; Pintilie, M; Schwock, J; Serra, S; Xu, J | 1 |
| Bhandari, DR; Cheng, M; Glunde, K; Heeren, RM; Jiang, L; Mascini, NE; Podmore, H; Rizwan, A; Römpp, A | 1 |
| Bar-Sagi, D; Grabocka, E; Mishra, B; Sundstrom, A | 1 |
| Cabrales, P; Minchinton, A; Oronsky, B; Scicinski, J | 1 |
| Fourcade, O; Geeraerts, T; Gonzalez, L; Kerhuel, L; Luzi, A; Mrozek, S | 1 |
| Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D | 1 |
| Barnes, SL; Kang, H; Quarles, CC; Sanchez, V; Sorace, AG; Syed, AK; Yankeelov, TE | 1 |
| Feng, F; Higashino, K; Kuge, Y; Masaki, Y; Numata, Y; Shimizu, Y; Yoshioka, T; Zhao, S | 1 |
| He, T; Xing, Y; Yang, N; Zhang, W | 1 |
| Crukley, C; Desjardins, L; Hadway, J; Lee, TY; Morrison, L; Stewart, E; Wang, Y | 1 |
| Baker, LCJ; Bhide, SA; Box, C; d'Arcy, JA; Dunlop, A; Eccles, SA; Harrington, KJ; Hopkinson, G; Koh, DM; Leach, MO; Mcquaid, D; Newbold, KL; Nutting, CM; Panek, R; Richardson, C; Riddell, AM; Robinson, SP; Schmidt, MA; Welsh, L; Wong, KH | 1 |
| Elias, AA; Maki, Y; Matushewski, B; Nygard, K; Regnault, TRH; Richardson, BS | 1 |
| Asada, Y; Iwakiri, T; Kawai, K; Kitamura, K; Koshimoto, C; Kuge, Y; Matsuura, Y; Sugita, C; Tamaki, N; Yamasaki, K; Yamashita, A; Zhao, S; Zhao, Y | 1 |
| Andersen, LMK; Galappathi, K; Gaustad, JV; Hauge, A; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
| Jayagopal, A; McCollum, GW; Penn, JS; Uddin, MI; Yang, R | 1 |
| Aishima, S; Kaneki, M; Kitajima, Y; Nakamura, J; Noshiro, H; Tanaka, T; Wakiyama, K; Yanagihara, K | 1 |
| Boult, JKR; Collins, DJ; d'Arcy, JA; Jerome, NP; Koh, DM; Leach, MO; Nerurkar, A; Orton, MR; Robinson, SP | 1 |
| Bayin, NS; Placantonakis, DG | 1 |
| Dadgar, S; Rajaram, N; Troncoso, JR | 1 |
| Baker, JHE; Kozlowski, P; Minchinton, AI; Moosvi, F; Reinsberg, SA; Yung, A | 1 |
| Bos, C; Deckers, R; Geerts, WJC; Kok, RJ; Lammers, T; Moonen, CTW; Sadeghi, N; Storm, G; Zandvliet, M | 1 |
| Andersen, LMK; Gaustad, JV; Hauge, A; Huang, R; Rofstad, EK; Simonsen, TG; Wegner, CS | 1 |
| Baumann, M; Bütof, R; Gudziol, V; Hering, S; Krause, M; Löck, S; Meneceur, S; Rehm, M; von Neubeck, C | 1 |
| Brolo, AG; Hindi, MN; Jirasek, A; Lum, JJ; Nicholson, LM; Pavey, N; Van Nest, SJ | 1 |
| Kosaka, M; Sakai-Sawada, K; Takei, N; Tamura, Y; Yoneda, A | 1 |
| Akama, T; Kojima, N; Kugawa, M; Mihara, H; Nishikawa, M; Sakai, Y; Sayo, K; Shinohara, M; Tao, F | 1 |
| Evans, RG; Ngo, JP; Ow, CPC; Sayakkarage, A; Ullah, MM | 1 |
| Nombela-Arrieta, C; Suessbier, U | 1 |
| Arias, SCA; Ávila, VF; Câmara, NOS; Fanelli, C; Faustino, VD; Foresto-Neto, O; Fujihara, CK; Malheiros, DMAC; Moreira, GCDS; Nascimento, TF; Rempel, LCT; Zatz, R | 1 |
| Dąbrowski, JM; Elas, M; Gonet, M; Karwicka, M; Pucelik, B | 1 |
| Dervis, E; Guldu, OK; Inci, ID; Karatay, KB; Kilcar, AY; Medine, EI; Muftuler, FZB; Tekin, V | 1 |
| Aarnes, EK; Evensen, TS; Fjeldbo, CS; Hillestad, T; Hompland, T; Kristensen, GB; Lund, KV; Lyng, H; Nilsen, A; Salberg, UB; Skingen, VE; Stokke, T | 1 |
| Guo, W; Wu, C | 1 |
| Fuentes, A; Healey, DR; Kodibagkar, VD; Quarles, CC; Scarpelli, ML | 1 |
| Cramer, RA; Grahl, N; Kowalski, CH | 1 |
| Bai, R; Chen, C; Du, P; Gao, F; Li, J; Liu, J; Liu, S; Liu, T; Lu, X; Ma, M; Qin, F; Wang, Y; Zhou, H | 1 |
| de Bree, R; H A M Kaanders, J; Philippens, MEP; Smits, HJG; Swartz, JE; Willems, SM | 1 |
| Labiano, S; Rodriguez-Ruiz, ME; Serrano-Mendioroz, I | 1 |
| Gaffney, J; Hompland, T; Leech, M; Leijenaar, RTH; Lyng, H; Marignol, L | 1 |
| Fukatsu, A; Inada, A | 1 |
8 review(s) available for azomycin and pimonidazole
| Article | Year |
|---|---|
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1986 |
Sensitizers and radiation dose fractionation: results and interpretations.
Topics: Animals; Combined Modality Therapy; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1986 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Sex-related liver injury due to alcohol involves activation of Kupffer cells by endotoxin.
Topics: Animals; Cell Hypoxia; Diet; Disease Models, Animal; Endotoxins; Ethanol; Female; Kupffer Cells; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver Diseases, Alcoholic; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Sex Factors; Tumor Necrosis Factor-alpha | 2000 |
Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; DNA-Binding Proteins; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Neoplasm Proteins; Nitroimidazoles; Nuclear Proteins; Oxygen; Radiation-Sensitizing Agents; Transcription Factors; Treatment Outcome; Vascular Endothelial Growth Factor A | 2003 |
22 trial(s) available for azomycin and pimonidazole
| Article | Year |
|---|---|
The combination of multiple doses of etanidazole and pimonidazole in 48 patients: a toxicity and pharmacokinetic study.
Topics: Adult; Aged; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Combinations; Etanidazole; Female; Humans; Male; Middle Aged; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508).
Topics: Aged; Clinical Trials as Topic; Etanidazole; Humans; Male; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
A multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Drug Combinations; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1989 |
Hypoxic cell radiosensitizers: illusion or elusion?
Topics: Clinical Trials as Topic; Drug Therapy, Combination; Etanidazole; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1988 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.
Topics: Drug Evaluation; Humans; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1984 |
A trial of Ro 03-8799 (pimonidazole) in carcinoma of the uterine cervix: an interim report from the Medical Research Council Working Party on advanced carcinoma of the cervix.
Topics: Adolescent; Adult; Aged; Blood Transfusion; Brachytherapy; Carcinoma, Squamous Cell; Diarrhea; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Remission Induction; Survival Rate; Uterine Cervical Neoplasms; Vomiting | 1993 |
A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.
Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Metallothionein; Neoplasm Staging; Nitroimidazoles; Proliferating Cell Nuclear Antigen; Protein Precursors; Uterine Cervical Neoplasms | 2000 |
Hypoxia and perfusion measurements in human tumors--initial experience with pimonidazole and IUdR.
Topics: Antibodies; Biopsy; Diffusion; Esophageal Neoplasms; Female; Head and Neck Neoplasms; Humans; Hypoxia; Idoxuridine; Kinetics; Male; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Rectal Neoplasms; Regional Blood Flow; Specimen Handling; Uterine Cervical Neoplasms | 2001 |
Phase 1 study to identify tumour hypoxia in patients with head and neck cancer using technetium-99m BRU 59-21.
Topics: Cell Hypoxia; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Injections, Intravenous; Laryngeal Neoplasms; Magnetic Resonance Imaging; Neoplasm Staging; Nitroimidazoles; Normal Distribution; Organotechnetium Compounds; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tomography, Emission-Computed | 2002 |
Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Combined Modality Therapy; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Proteins; Niacinamide; Nitroimidazoles; Oxygen; Predictive Value of Tests; Treatment Outcome | 2002 |
The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study.
Topics: Adult; Aged; Aged, 80 and over; Cell Hypoxia; Female; Humans; Middle Aged; Nitroimidazoles; Oxygen; Partial Pressure; Prognosis; Prospective Studies; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2006 |
The fate of hypoxic (pimonidazole-labelled) cells in human cervix tumours undergoing chemo-radiotherapy.
Topics: Adult; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Combined Modality Therapy; Female; Humans; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Spheroids, Cellular; Uterine Cervical Neoplasms | 2006 |
Investigation of possible endogenous hypoxia markers in colorectal cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Hypoxia; Colorectal Neoplasms; Female; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Microvessels; Middle Aged; Monocarboxylic Acid Transporters; Nitroimidazoles; Procollagen-Proline Dioxygenase; Radiation-Sensitizing Agents; Survival Analysis | 2013 |
Pattern of CAIX expression is prognostic for outcome and predicts response to ARCON in patients with laryngeal cancer treated in a phase III randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Female; Humans; Laryngeal Neoplasms; Male; Middle Aged; Niacinamide; Nitroimidazoles; Oxygen; Prognosis; Treatment Outcome | 2013 |
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Topics: Adult; Aged; Anemia; Antigens, Neoplasm; Antineoplastic Agents, Alkylating; Biomarkers; Bone Marrow; Carbonic Anhydrase IX; Carbonic Anhydrases; Enterocolitis; Female; Gene Expression; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutropenia; Nitrogen Mustard Compounds; Nitroimidazoles; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Recurrence; Remission Induction; Thrombocytopenia | 2015 |
Analysis of the intra- and intertumoral heterogeneity of hypoxia in pancreatic cancer patients receiving the nitroimidazole tracer pimonidazole.
Topics: Adult; Analysis of Variance; Carcinoma, Pancreatic Ductal; Cell Hypoxia; Feasibility Studies; Female; Humans; Immunohistochemistry; Indicators and Reagents; Injections, Intravenous; Male; Nitroimidazoles; Pancreas; Pancreatectomy; Pancreatic Neoplasms; Premedication; Selection Bias | 2015 |
Correlation and colocalization of HIF-1α and pimonidazole staining for hypoxia in laryngeal squamous cell carcinomas: A digital, single-cell-based analysis.
Topics: Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Laryngeal Neoplasms; Nitroimidazoles; Prognosis; Squamous Cell Carcinoma of Head and Neck; Staining and Labeling | 2022 |
339 other study(ies) available for azomycin and pimonidazole
| Article | Year |
|---|---|
Tumor blood flow changes induced by chemical modifiers of radiation response.
Topics: Animals; Antineoplastic Agents; Blood Flow Velocity; Cisplatin; Doxorubicin; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
A comparison of radiosensitization by etanidazole and pimonidazole in mouse tumors.
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Radiosensitization by the combination of etanidazole (SR-2508) and pimonidazole (Ro 03-8799) in human tumor xenografts.
Topics: Adenocarcinoma; Animals; Cell Survival; Drug Synergism; Etanidazole; Female; Humans; Melanoma; Mice; Mice, Nude; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage; Rectal Neoplasms | 1991 |
Radiosensitization of Chinese hamster cells by pimonidazole (Ro 03-8799) at low X-ray doses.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Misonidazole; Nitroimidazoles; Oxygen; Radiation Dosage; Radiation-Sensitizing Agents | 1991 |
Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.
Topics: Animals; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Humans; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tumor Cells, Cultured | 1990 |
Lack of stereoselectivity in the pharmacokinetics and metabolism of the radiosensitizer Ro 03-8799 in man.
Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Stereoisomerism | 1991 |
[Radiosensitization by hypoxic cell radiosensitizer--present status of radiosensitizer].
Topics: Cell Hypoxia; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1990 |
Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
Topics: Animals; Antineoplastic Agents; Autoradiography; Male; Melanins; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1990 |
[New results with delayed progression in the cell cycle of solid squamous cell carcinomas of the head-neck area after single and fractionated irradiation with cobalt-60 and neutrons].
Topics: Animals; Carcinoma, Squamous Cell; Cell Cycle; Cobalt Radioisotopes; Head and Neck Neoplasms; Neoplasm Transplantation; Neutrons; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Transplantation, Heterologous | 1990 |
Radiotherapy using the hypoxic cell sensitizer Ro 03-8799 in malignant melanoma.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Hypoxia; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Palliative Care; Radiation Tolerance; Radiation-Sensitizing Agents; Skin Neoplasms | 1987 |
Accelerated elimination of pimonidazole following microsomal enzyme induction in mice: a possible approach to reduced neurotoxicity of the pimonidazole-etanidazole combination.
Topics: Animals; Brain; Drug Combinations; Enzyme Induction; Etanidazole; Mice; Mice, Inbred C3H; Microsomes, Liver; Neoplasm Transplantation; Nitroimidazoles; Phenobarbital; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Evaluation of nitroimidazole hypoxic cell radiosensitizers in a human tumor cell line high in intracellular glutathione.
Topics: Cell Line; Drug Evaluation, Preclinical; Etanidazole; Glutathione; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Ro 03-8799: preferential relative uptake in human tumor xenografts compared to a murine tumor: comparison with SR-2508.
Topics: Animals; Cell Line; Etanidazole; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1989 |
Oncogenic transforming potential of nitroimidazole radiosensitizers.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1989 |
The uptake of the radiosensitizing compound Ro 03-8799 (Pimonidazole) in human tumors.
Topics: Breast Neoplasms; Female; Humans; Melanoma; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Rectal Neoplasms; Uterine Cervical Neoplasms | 1989 |
Pharmacokinetics of Ro 03-8799 in mice bearing melanosarcoma: comparison with tumors without melanin.
Topics: Animals; Lung Neoplasms; Melanins; Melanoma, Experimental; Mice; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Combined effects of X rays, Ro 03-8799, and hyperthermia on growth, necrosis, and cell proliferation in a mouse tumor.
Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
A comparison of colorimetric and clonogenic assays for hypoxic-specific toxins with hamster and human cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Colorimetry; Drug Screening Assays, Antitumor; Humans; Misonidazole; Nitroimidazoles; Oxygen; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.
Topics: Animals; Body Temperature; Hyperthermia, Induced; Lethal Dose 50; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Effects on intermediary metabolism in mouse tissues by Ro-03-8799.
Topics: Adenocarcinoma; Animals; Body Temperature; Brain; Glucose; Glucose-6-Phosphatase; Ketone Bodies; Lipid Metabolism; Liver; Liver Glycogen; Male; Mice; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1987 |
Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Brain Neoplasms; Drug Therapy, Combination; Etanidazole; Glioblastoma; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Cytocidal effects of misonidazole, Ro 03-8799, and RSU-1164 on euoxic and hypoxic BP-8 murine sarcoma cells at normal and elevated temperatures.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Iodine Radioisotopes; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured | 1989 |
A phase I study of the combined hypoxic cell radiosensitizers, Ro 03-8799 and SR 2508: a preliminary report of single-dose toxicity, pharmacokinetics and tumour concentrations.
Topics: Adenocarcinoma; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Radiosensitization of hypoxic cells at low doses.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Etanidazole; In Vitro Techniques; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1986 |
Sensitization by SR-2508 plus Ro 03-8799.
Topics: Animals; Combined Modality Therapy; Drug Combinations; Etanidazole; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.
Topics: Aged; Etanidazole; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics.
Topics: Adolescent; Adult; Aged; Combined Modality Therapy; Drug Combinations; Drug Evaluation; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice.
Topics: Animals; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1986 |
Gradient high-performance liquid chromatographic method for simultaneous assay of the radiosensitizers etanidazole (SR 2508) and pimonidazole (Ro 03-8799) in biological materials.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Etanidazole; Humans; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
Uptake and additivity of the radiosensitizing effects of Ro 03-8799 and SR-2508 in mammalian cells in vitro.
Topics: Animals; Cell Line; Cricetinae; Drug Synergism; Etanidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1987 |
[Present status of hypoxic cell sensitizers and PLDR inhibitors].
Topics: Animals; Cell Cycle; Cell Line; Etanidazole; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1987 |
When can the infusion period be safely ignored in the estimation of pharmacokinetic parameters of drugs in humans?
Topics: Algorithms; Antineoplastic Agents; Carmustine; Etanidazole; Humans; Infusions, Intravenous; Models, Biological; Nitroimidazoles; Time Factors | 1988 |
Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system.
Topics: Animals; Cell Survival; Drug Therapy, Combination; Etanidazole; Female; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Interactions of hyperthermia with hypoxic cell sensitisers.
Topics: Animals; Combined Modality Therapy; Etanidazole; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1988 |
The multi-dose clinical tolerance and pharmacokinetics of the combined radiosensitizers, Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).
Topics: Adult; Aged; Combined Modality Therapy; Drug Therapy, Combination; Etanidazole; Humans; Middle Aged; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Antagonism between radiosensitizing agents.
Topics: Dose-Response Relationship, Drug; Etanidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
An in vitro and in vivo screening system for new hypoxic cell radiosensitizers using EMT6 cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tetrazoles | 1986 |
Autoradiographic distribution of [14C]-labelled pimonidazole in rhabdomyosarcoma-bearing rats and pigmented mice.
Topics: Animals; Autoradiography; Male; Mice; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; Tissue Distribution | 1988 |
The effects of whole body hyperthermia on the pharmacokinetics and toxicity of the basic 2-nitroimidazole radiosensitizer Ro 03-8799 in mice.
Topics: Animals; Body Temperature; Brain; Chromatography, High Pressure Liquid; Female; Glomerular Filtration Rate; Hyperthermia, Induced; Kinetics; Male; Mice; Mice, Inbred C3H; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1987 |
A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799.
Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cricetinae; Cricetulus; Female; Humans; Male; Melanoma; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 1986 |
A comparative study of Ro 03-8799: racemic mixture and enantiomers.
Topics: Dose-Response Relationship, Drug; Humans; Isomerism; Molecular Conformation; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
In vitro assessment of the oncogenic potential of nitroimidazole radiosensitizers.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange; Time Factors | 1985 |
Cellular uptake of misonidazole and analogues with acidic or basic functions.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Extracellular Space; Fibroblasts; Hydrogen-Ion Concentration; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Time Factors | 1985 |
The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Cell Survival; Cricetinae; Extracellular Space; Fibroblasts; Hydrogen-Ion Concentration; In Vitro Techniques; Misonidazole; Nimorazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 1985 |
A clinical phase I toxicity study of Ro 03-8799: plasma, urine, tumour and normal brain pharmacokinetics.
Topics: Astrocytoma; Brain; Brain Diseases; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Evaluation; Humans; Kinetics; Neoplasms; Nitroimidazoles | 1986 |
The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799.
Topics: Animals; Kinetics; Mice; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents | 1985 |
Radiosensitizers of hypoxic mammalian cells. 1-(Hydroxyaminoalkyl)-substituted nitroimidazoles.
Topics: Animals; Cell Division; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Morphological changes in rat hepatocytes in primary culture induced by Misonidazole, desmethylmisonidazole and Ro 03-8799.
Topics: Animals; Cell Survival; Cells, Cultured; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats | 1984 |
A comparison of the ability of some radiosensitizers undergoing clinical trials to act as chemosensitizers.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The clinical testing of Ro 03-8799--pharmacokinetics, toxicology, tissue and tumor concentrations.
Topics: Drug Evaluation; Female; Humans; Male; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Tissue Distribution | 1984 |
The pharmacokinetics of a new radiosensitiser, Ro 03-8799 in humans.
Topics: Adult; Aged; Blood Proteins; Erythrocytes; Feces; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Neoplasms; Nitroimidazoles; Oxides; Protein Binding; Radiation-Sensitizing Agents; Time Factors | 1984 |
Radiosensitization of a mouse tumour by Ro 03-8799: acute and protracted administration.
Topics: Animals; Injections, Intraperitoneal; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1983 |
Effect of the nitroimidazole Ro 03-8799 on the activity of chemotherapeutic agents against a murine tumour in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitroimidazoles; Tumor Stem Cell Assay | 1984 |
High-performance liquid chromatographic analysis of the new hypoxic cell radiosensitiser, Ro 03-8799, in biological samples.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Erythrocytes; Humans; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrophotometry, Ultraviolet; Time Factors | 1983 |
Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Male; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Skin | 1982 |
The radiosensitizer Ro 03-8799 and the concentrations which may be achieved in human tumours: a preliminary study.
Topics: Adult; Aged; Female; Half-Life; Humans; Male; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1982 |
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver.
Topics: Animals; Biomarkers; Cell Hypoxia; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Liver; Nitroimidazoles; Oxygen; Perfusion; Rabbits; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley | 1995 |
Relationship between intracellular concentration and radiosensitizing effect of pimonidazole and etanidazole on two human melanoma cell lines.
Topics: Etanidazole; Humans; In Vitro Techniques; Melanoma; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Relationship between the melanin content of a human melanoma cell line and its radiosensitivity and uptake of pimonidazole.
Topics: Animals; Autoradiography; Cell Line; Etanidazole; Humans; Melanins; Melanoma; Mice; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1993 |
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
Topics: Acridines; Animals; Cell Hypoxia; Cell Membrane; Cricetinae; Cricetulus; Diffusion; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Phenanthridines | 1996 |
Marking hypoxic cells for complement and cytotoxic T lymphocyte-mediated lysis: using pimonidazole.
Topics: Animals; Antigens; Cell Hypoxia; Complement System Proteins; Cytotoxicity, Immunologic; Mice; Mice, Inbred C3H; Nitroimidazoles; Rabbits; Radiation-Sensitizing Agents; T-Lymphocytes, Cytotoxic | 1996 |
Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo.
Topics: Animals; Aspartate Aminotransferases; Cell Hypoxia; Disease Models, Animal; Ethanol; Liver; Liver Diseases, Alcoholic; Male; Nitroimidazoles; Rats; Rats, Wistar | 1997 |
Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays.
Topics: Adult; Antigens, Nuclear; Biomarkers; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Nitroimidazoles; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 1997 |
Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime.
Topics: Animals; Cell Survival; DNA Adducts; DNA, Neoplasm; Dog Diseases; Dogs; Hypoxia; Neoplasms; Nitroimidazoles | 1997 |
Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Eating; Enzyme-Linked Immunosorbent Assay; Fasting; Glycolysis; Hypoxia; In Vitro Techniques; Kinetics; Liver; Microsomes, Liver; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Potassium Cyanide; Radiation-Sensitizing Agents; Rats | 1998 |
Identification of nonproliferating but viable hypoxic tumor cells in vivo.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cell Hypoxia; Cell Separation; Flow Cytometry; Humans; Mice; Mice, SCID; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinomas using pimonidazole as a hypoxia marker.
Topics: Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Endothelial Growth Factors; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Lymphokines; Nitroimidazoles; Uterine Cervical Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine.
Topics: Animals; Creatinine; Cyclosporine; Food, Fortified; Free Radicals; Glomerular Filtration Rate; Glycine; Hypoxia; Kidney; Male; Models, Biological; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors; Vasoconstriction | 1998 |
Pimonidazole: a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
Topics: Biomarkers; Cell Division; Cell Hypoxia; Female; Humans; Immunohistochemistry; Nitroimidazoles; Proliferating Cell Nuclear Antigen; S Phase; Uterine Cervical Neoplasms | 1998 |
Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors.
Topics: Animals; Biomarkers; Cell Hypoxia; Electrodes; Female; Immunohistochemistry; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1999 |
Graft survival is improved by hepatic denervation before organ harvesting.
Topics: Animals; Antihypertensive Agents; Denervation; Female; Graft Survival; Hepatic Artery; Hexamethonium; Hypoxia; Liver; Liver Transplantation; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Lew; Reperfusion Injury; Tissue and Organ Procurement | 1999 |
Reperfusion injury in livers due to gentle in situ organ manipulation during harvest involves hypoxia and free radicals.
Topics: Animals; Cryopreservation; Enzyme-Linked Immunosorbent Assay; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Free Radicals; Hypoxia; Immunohistochemistry; In Vitro Techniques; Liver; Microcirculation; Nitroimidazoles; Organ Preservation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Specimen Handling; Trypan Blue | 1999 |
Hepatocellular hypoxia-induced vascular endothelial growth factor expression and angiogenesis in experimental biliary cirrhosis.
Topics: Animals; Blotting, Western; Cell Hypoxia; Endothelial Growth Factors; Fibroblast Growth Factor 2; Immunohistochemistry; Ki-67 Antigen; Liver Cirrhosis, Biliary; Liver Cirrhosis, Experimental; Lymphokines; Male; Neovascularization, Pathologic; Nitroimidazoles; Protein Isoforms; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Radiobiological and immunohistochemical assessment of hypoxia in human melanoma xenografts: acute and chronic hypoxia in individual tumours.
Topics: Acute Disease; Animals; Cell Hypoxia; Cell Separation; Cell Survival; Chronic Disease; Dose-Response Relationship, Radiation; Female; Humans; Immunohistochemistry; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiobiology; Staining and Labeling; Transplantation, Heterologous; Tumor Cells, Cultured | 1999 |
Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status.
Topics: Animals; Antineoplastic Agents; Blood Vessels; Brain Neoplasms; Glioma; Humans; Hypoxia; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Staining and Labeling; Suramin; Transplantation, Heterologous | 1999 |
Early wound healing exhibits cytokine surge without evidence of hypoxia.
Topics: Animals; Benzimidazoles; Cell Division; Cell Hypoxia; Cytokines; DNA Adducts; Endothelial Growth Factors; Female; Fluorescent Dyes; Ki-67 Antigen; Lymphokines; Microscopy, Fluorescence; Neovascularization, Physiologic; Nitroimidazoles; Rats; Rats, Inbred F344; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing | 2000 |
Diffusion limited hypoxia estimated by vascular image analysis: comparison with pimonidazole staining in human tumors.
Topics: Adenocarcinoma; Blood Vessels; Carcinoma, Squamous Cell; Cell Hypoxia; Diffusion; Esophageal Neoplasms; Female; Humans; Image Processing, Computer-Assisted; Nitroimidazoles; Observer Variation; Radiation-Sensitizing Agents; Rectal Neoplasms; Reproducibility of Results; Uterine Cervical Neoplasms | 2000 |
Vascular architecture and hypoxic profiles in human head and neck squamous cell carcinomas.
Topics: Aged; Biomarkers; Biopsy; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypopharyngeal Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Laryngeal Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Nitroimidazoles; Oropharyngeal Neoplasms; Prognosis | 2000 |
Prediction of tumor response to therapy: molecular markers and the microenvironment. Apoptosis and chips: an overview of the proceedings.
Topics: Apoptosis; Biomarkers, Tumor; Biopsy; Cell Cycle; Cell Hypoxia; Cell Survival; Comet Assay; DNA Ligases; Enzyme Activation; Genes, ras; Humans; Immunohistochemistry; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Nitroimidazoles; Oligonucleotide Array Sequence Analysis; Predictive Value of Tests; Radiation Tolerance; Radiotherapy Dosage; Tumor Cells, Cultured | 2000 |
Hypoxia in a human intracerebral glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Disease Models, Animal; Glioma; Hypoxia; Mice; Mice, Inbred BALB C; Microcirculation; Nitroimidazoles; Radiation-Sensitizing Agents | 2000 |
Spatial relationship between hypoxia and the (perfused) vascular network in a human glioma xenograft: a quantitative multi-parameter analysis.
Topics: Animals; Benzimidazoles; Cell Hypoxia; Fluorescent Dyes; Glioma; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Radiation-Sensitizing Agents; Regional Blood Flow; Theophylline; Transplantation, Heterologous | 2000 |
Optical sensor-based oxygen tension measurements correspond with hypoxia marker binding in three human tumor xenograft lines.
Topics: Animals; Binding Sites; Biosensing Techniques; Cell Hypoxia; Humans; Luminescent Measurements; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Effects of nicotinamide and carbogen on oxygenation in human tumor xenografts measured with luminescense based fiber-optic probes.
Topics: Analysis of Variance; Animals; Carbon Dioxide; Cell Hypoxia; Disease Models, Animal; Fiber Optic Technology; Humans; Linear Models; Luminescent Measurements; Niacinamide; Nitroimidazoles; Optical Fibers; Oxygen; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured | 2000 |
Comparison between the comet assay and pimonidazole binding for measuring tumour hypoxia.
Topics: Animals; Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Hypoxia; Comet Assay; Cricetinae; Cricetulus; DNA, Neoplasm; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Immunoconjugates; Male; Mice; Mice, Inbred C3H; Mice, Inbred NOD; Mice, SCID; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2000 |
Estimation of oxygen distribution in RIF-1 tumors by diffusion model-based interpretation of pimonidazole hypoxia and eppendorf measurements.
Topics: Animals; Cell Hypoxia; Data Interpretation, Statistical; Diffusion; Female; Fibrosarcoma; Kinetics; Mice; Models, Biological; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Radiation-Sensitizing Agents; Staining and Labeling | 2001 |
Changes in tumor hypoxia measured with a double hypoxic marker technique.
Topics: Animals; Benzimidazoles; Biomarkers; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Endothelium, Vascular; Fluorescent Dyes; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2000 |
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Topics: Blotting, Western; Carbonic Anhydrases; Carcinoma; Carcinoma, Renal Cell; DNA-Binding Proteins; Endothelial Growth Factors; Genes, Reporter; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Kidney Neoplasms; Lymphokines; Models, Genetic; Necrosis; Nitroimidazoles; Nuclear Proteins; Oxygen; Plasmids; Promoter Regions, Genetic; Radiation-Sensitizing Agents; RNA; RNA, Messenger; Skin Neoplasms; Transcription Factors; Tumor Cells, Cultured; Up-Regulation; Urinary Bladder Neoplasms; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2000 |
Determination of hypoxic region by hypoxia marker in developing mouse embryos in vivo: a possible signal for vessel development.
Topics: Animals; Antibodies, Monoclonal; Biomarkers; Blood Vessels; Brain; Bucladesine; Cell Differentiation; Cell Hypoxia; DNA-Binding Proteins; Embryonic and Fetal Development; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation, Developmental; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Lymphokines; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nuclear Proteins; Platelet Endothelial Cell Adhesion Molecule-1; Stem Cells; Teratoma; Transcription Factors; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Semiquantitative immunohistochemical analysis for hypoxia in human tumors.
Topics: Calibration; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Nitroimidazoles; Observer Variation; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2001 |
Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Cell Hypoxia; Female; Humans; Middle Aged; Nitroimidazoles; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 2001 |
HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha.
Topics: Animals; Cell Line; Endothelial Growth Factors; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Interleukin-1; Lymphokines; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344; Time Factors; Transcription Factors; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing | 2001 |
Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Female; Glioma; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2001 |
Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis.
Topics: Animals; Cell Hypoxia; Cells, Cultured; Cyclic AMP; Hepatocyte Growth Factor; Hepatocytes; Humans; Liver; Liver Cirrhosis, Experimental; Male; Nitroimidazoles; Proto-Oncogene Proteins c-met; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Regeneration; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Measuring hypoxia in solid tumours--is there a gold standard?
Topics: Biopsy, Needle; Comet Assay; Humans; Hypoxia; Microelectrodes; Neoplasms; Nitroimidazoles; Palliative Care; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiotherapy; Reference Values | 2001 |
Local hypoxia is produced at sites of intratumour injection.
Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Hypoxia; Comet Assay; DNA Damage; Humans; Injections; Mice; Nitroimidazoles; Radiation-Sensitizing Agents | 2002 |
Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
Topics: Animals; Cell Survival; Cyclooxygenase 2; DNA Primers; Exons; Gene Expression Regulation; Genetic Markers; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Introns; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Polymerase Chain Reaction; Prostaglandin-Endoperoxide Synthases; Radiation-Sensitizing Agents; RNA, Messenger; Thymus Gland; Transcription, Genetic | 2002 |
Why do hypoxic cells behave badly?
Topics: Cell Hypoxia; Humans; Immunohistochemistry; Infusions, Intravenous; Neoplasm Invasiveness; Neoplasms; Nitroimidazoles; Oxygen; Prognosis; Sensitivity and Specificity; Tumor Cells, Cultured | 2000 |
Hypoxia promotes lymph node metastasis in human melanoma xenografts by up-regulating the urokinase-type plasminogen activator receptor.
Topics: Animals; Cell Hypoxia; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Melanoma; Mice; Mice, Inbred BALB C; Nitroimidazoles; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transplantation, Heterologous; Tumor Cells, Cultured; Up-Regulation | 2002 |
Quantitative analysis of varying profiles of hypoxia in relation to functional vessels in different human glioma xenograft lines.
Topics: Animals; Glioma; Humans; Hypoxia; Immunohistochemistry; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Perfusion; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Chronic renal hypoxia after acute ischemic injury: effects of L-arginine on hypoxia and secondary damage.
Topics: Acute Kidney Injury; Animals; Arginine; Chronic Disease; Disease Progression; Hypoxia; Ischemia; Kidney; Kidney Diseases; Kidney Failure, Chronic; Male; Nephrectomy; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Time Factors | 2003 |
HIF-1A, pimonidazole, and iododeoxyuridine to estimate hypoxia and perfusion in human head-and-neck tumors.
Topics: Carcinoma, Squamous Cell; Dimerization; Dose-Response Relationship, Drug; Head and Neck Neoplasms; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Idoxuridine; Immunohistochemistry; Ki-67 Antigen; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Perfusion; Transcription Factors; Treatment Outcome | 2002 |
Orally administered pimonidazole to label hypoxic tumor cells.
Topics: Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Flow Cytometry; Humans; Male; Mice; Mice, SCID; Neoplasm Transplantation; Nitroimidazoles; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2002 |
GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding.
Topics: Adult; Antigens, Neoplasm; Biomarkers; Biopsy; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; DNA-Binding Proteins; Energy Metabolism; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Microelectrodes; Middle Aged; Monosaccharide Transport Proteins; Neoplasm Proteins; Nitroimidazoles; Nuclear Proteins; Observer Variation; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Reproducibility of Results; Transcription Factors; Uterine Cervical Neoplasms | 2003 |
Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas.
Topics: Adolescent; Adult; Analysis of Variance; Carcinoma; Cell Hypoxia; Computer Graphics; Female; Humans; Microelectrodes; Nitroimidazoles; Oxygen; Polarography; Radiation-Sensitizing Agents; Retrospective Studies; Statistics, Nonparametric; Uterine Cervical Neoplasms | 2003 |
Pimonidazole binding in C6 rat brain glioma: relation with lipid droplet detection.
Topics: Animals; Brain; Cell Hypoxia; Glioma; Immunohistochemistry; Lipids; Microcirculation; Neovascularization, Pathologic; Nitroimidazoles; Radiation-Sensitizing Agents; Rats | 2003 |
Is HIF-1alpha a good marker for tumor hypoxia?
Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Transcription Factors | 2003 |
Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies.
Topics: Animals; Biomarkers, Tumor; Blotting, Western; Cell Hypoxia; Female; Flow Cytometry; Fluorescent Antibody Technique; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, SCID; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Transcription Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 2003 |
Cellular responses to hypoxia after renal segmental infarction.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Division; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction; Kidney; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Renal Circulation; Trans-Activators; Transcription Factors; Vascular Endothelial Growth Factor A | 2003 |
Chronic intragastric alcohol exposure causes hypoxia and oxidative stress in the rat pancreas.
Topics: Aldehydes; Amylases; Animals; Blood Pressure; Cell Hypoxia; Diet; Ethanol; Lipase; Male; Models, Biological; Nitroimidazoles; Oxidative Stress; Pancreas; Rats; Rats, Wistar; Time Factors | 2003 |
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
Topics: Biopsy; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Female; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; Metallothionein; Nitroimidazoles; Oxygen; Prognosis; Protein Precursors; Radiation-Sensitizing Agents; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms | 2003 |
The effect of elevated intraocular oxygen on organelle degradation in the embryonic chicken lens.
Topics: Animals; Body Weights and Measures; Chick Embryo; Lens, Crystalline; Microscopy, Confocal; Models, Biological; Nitroimidazoles; Organelles; Oxygen; Partial Pressure | 2003 |
Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Arrhythmias, Cardiac; Cation Transport Proteins; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Female; Fetal Hypoxia; Image Processing, Computer-Assisted; Injections, Intravenous; Nitroimidazoles; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pregnancy; Propanolamines; Rats; Rats, Sprague-Dawley; Teratogens; Videotape Recording | 2003 |
TNP-470 promotes initial vascular sprouting in xenograft tumors.
Topics: Angiogenesis Inhibitors; Angiography; Animals; Antibiotics, Antineoplastic; Apoptosis; Capillaries; Cell Line, Tumor; Cyclohexanes; Fluorescein; Humans; Hypoxia; Immunohistochemistry; In Situ Hybridization; In Situ Nick-End Labeling; Lectins; Mice; Mice, Nude; Microcirculation; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; O-(Chloroacetylcarbamoyl)fumagillol; Radiation-Sensitizing Agents; Sesquiterpenes; Vascular Endothelial Growth Factor A; Wilms Tumor | 2004 |
Differentiation-associated staining with anti-pimonidazole antibodies in head and neck tumors.
Topics: Antibodies, Anti-Idiotypic; Biomarkers; Carcinoma, Squamous Cell; Flow Cytometry; Frozen Sections; Head and Neck Neoplasms; Humans; Hypoxia; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Staining and Labeling | 2004 |
Improved immunohistochemical method for detecting hypoxia gradients in mouse tissues and tumors.
Topics: Animals; Antibodies, Monoclonal; Cell Hypoxia; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Organ Specificity | 2004 |
Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model.
Topics: Abdominal Neoplasms; Animals; Cell Hypoxia; Cell Line, Tumor; Disease Progression; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Nitroimidazoles; Oxygen; Pancreatic Neoplasms; Partial Pressure; Staining and Labeling | 2004 |
The immunohistochemical assessment of hypoxia, vascularity and proliferation in bladder carcinoma.
Topics: Antigens, CD34; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cell Hypoxia; Cell Proliferation; Cyclin A; Female; Humans; Immunohistochemistry; Ki-67 Antigen; Male; Neoplasm Staging; Neovascularization, Pathologic; Nitroimidazoles; Platelet Endothelial Cell Adhesion Molecule-1; Radiation-Sensitizing Agents; Staining and Labeling; Urinary Bladder Neoplasms | 2004 |
Effects of nicotinamide and carbogen in different murine colon carcinomas: immunohistochemical analysis of vascular architecture and microenvironmental parameters.
Topics: Animals; Benzimidazoles; Bromodeoxyuridine; Carbon Dioxide; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Niacinamide; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 2004 |
Tumor-dependent kinetics of partial pressure of oxygen fluctuations during air and oxygen breathing.
Topics: Air; Animals; Cell Hypoxia; Female; Fibrosarcoma; Fourier Analysis; Glioma; Immunohistochemistry; Nitroimidazoles; Oxygen; Partial Pressure; Rats; Rats, Inbred F344 | 2004 |
Quantifying transient hypoxia in human tumor xenografts by flow cytometry.
Topics: Adenocarcinoma; Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Flow Cytometry; Humans; Mice; Mice, SCID; Nitroimidazoles; Oxygen; Partial Pressure; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2004 |
Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry.
Topics: Animals; Antibodies, Monoclonal; Carbonic Anhydrase III; Cell Hypoxia; Fluorodeoxyglucose F18; Heart; Immunoenzyme Techniques; Lung; Male; Misonidazole; Muscles; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rhabdomyosarcoma | 2004 |
Mechanism of hypertensive nephropathy in the Dahl/Rapp rat: a primary disorder of vascular smooth muscle.
Topics: Animals; Bromodeoxyuridine; Cell Hypoxia; Cell Proliferation; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Muscle, Smooth, Vascular; Nitroimidazoles; Rats; Rats, Inbred Dahl; Renal Insufficiency; Sodium Chloride; Sucrose; Time Factors; Transcription Factors | 2005 |
Hypoxia-inducible factor 1alpha expression as an intrinsic marker of hypoxia: correlation with tumor oxygen, pimonidazole measurements, and outcome in locally advanced carcinoma of the cervix.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Disease-Free Survival; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Ion-Selective Electrodes; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Survival Rate; Transcription Factors; Treatment Outcome; Uterine Cervical Neoplasms | 2004 |
Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia.
Topics: Disease-Free Survival; Erythropoietin; Head and Neck Neoplasms; Humans; Hypoxia; Immunohistochemistry; Ligands; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Receptors, Erythropoietin; Recombinant Proteins; Time Factors | 2005 |
Up-regulation of HIF in experimental acute renal failure: evidence for a protective transcriptional response to hypoxia.
Topics: Acute Kidney Injury; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Furosemide; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Iothalamic Acid; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Trans-Activators; Transcription Factors; Transcription, Genetic; Up-Regulation | 2005 |
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
Topics: Animals; Autoradiography; Benzimidazoles; Cell Hypoxia; Coordination Complexes; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rats, Nude; Thiosemicarbazones; Transplantation, Heterologous | 2005 |
Dependence of FDG uptake on tumor microenvironment.
Topics: Animals; Autoradiography; Benzimidazoles; Bromodeoxyuridine; Cell Hypoxia; Cell Proliferation; Coloring Agents; Fluorodeoxyglucose F18; Glucose; Male; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Prostatic Neoplasms; Radiopharmaceuticals | 2005 |
Hypoxic cell turnover in different solid tumor lines.
Topics: Animals; Benzimidazoles; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Coloring Agents; Half-Life; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Nitroimidazoles; Time Factors | 2005 |
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; DNA, Mitochondrial; Electron Transport; Fluorescent Dyes; Gene Expression Regulation; Humans; Hypoxia; Microscopy, Fluorescence; Mitochondria; Models, Theoretical; Nitroimidazoles; Osteosarcoma; Oxygen; Oxygen Consumption; Vascular Endothelial Growth Factor A | 2005 |
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
Topics: Animals; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Hypoxia; Disease Progression; Flow Cytometry; Hematopoiesis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Leukocyte Common Antigens; Mice; Multiple Myeloma; Neovascularization, Pathologic; Nitroimidazoles | 2005 |
Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines.
Topics: Animals; Antigens, Neoplasm; Benzimidazoles; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles | 2005 |
Does heterogeneity of pimonidazole labelling correspond to the heterogeneity of radiation-response of FaDu human squamous cell carcinoma?
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose-Response Relationship, Radiation; Female; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiation Tolerance | 2005 |
The use of pimonidazole to characterise hypoxia in the internal environment of an in vivo tissue engineering chamber.
Topics: Animals; Arteriovenous Shunt, Surgical; Biomarkers; Cell Division; Cell Hypoxia; Cell Movement; Cells, Cultured; Diffusion Chambers, Culture; Endothelium, Vascular; Fibrin; Fibroblasts; Gels; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Engineering | 2005 |
Reduced expression of hypoxia-inducible factor-1alpha in perinecrotic regions of solid tumors.
Topics: Animals; Antigens, Neoplasm; Astrocytoma; Biomarkers, Tumor; Biopsy; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Colonic Neoplasms; Female; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Mice; Mice, SCID; Necrosis; Neoplasms; Nitroimidazoles; Transcription Factors; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2005 |
Erythropoietin receptor is not a surrogate marker for tumor hypoxia and does not correlate with survival in head and neck squamous cell carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Nitroimidazoles; Receptors, Erythropoietin; Survival Rate | 2005 |
Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2.
Topics: Angiotensin I; Angiotensin-Converting Enzyme 2; Animals; Aorta, Thoracic; Carboxypeptidases; Cell Hypoxia; Cells, Cultured; Chronic Disease; Disease Models, Animal; Female; Hepatitis C, Chronic; Hepatocytes; Humans; Immunoenzyme Techniques; Liver; Liver Cirrhosis; Male; Nitroimidazoles; Peptide Fragments; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Vasodilation | 2005 |
Gadopentetate dimeglumine and FDG uptake in liver metastases of colorectal carcinoma as determined with MR imaging and PET.
Topics: Adult; Aged; Cell Hypoxia; Colorectal Neoplasms; Contrast Media; Female; Fluorodeoxyglucose F18; Gadolinium DTPA; Humans; Liver Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals | 2005 |
Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer.
Topics: Adult; Aged; Biomarkers, Tumor; Carbonic Anhydrases; Cell Hypoxia; Cell Proliferation; Colorectal Neoplasms; Female; Glucose Transporter Type 1; Humans; Idoxuridine; Liver Neoplasms; Male; Middle Aged; Nitroimidazoles | 2006 |
Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins.
Topics: Acute Kidney Injury; Animals; Biomarkers; Bone Morphogenetic Protein 7; Bone Morphogenetic Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Death; Hypoxia; Immunohistochemistry; Kidney; Kidney Tubules; Male; Nitroimidazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Regeneration; Reperfusion Injury; Smad Proteins | 2006 |
A comparison of oral and intravenous pimonidazole in canine tumors using intravenous CCI-103F as a control hypoxia marker.
Topics: Administration, Oral; Animals; Area Under Curve; Cell Hypoxia; Cell Line; Cricetinae; Cricetulus; Dog Diseases; Dogs; Feasibility Studies; Hydrogen-Ion Concentration; Injections, Intravenous; Neoplasms; Nitroimidazoles | 2006 |
Comparison between pimonidazole binding, oxygen electrode measurements, and expression of endogenous hypoxia markers in cancer of the uterine cervix.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Biopsy; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cervix Uteri; DNA, Neoplasm; Electrodes; Female; Flow Cytometry; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Middle Aged; Nitroimidazoles; Oxygen; Phenotype; Predictive Value of Tests; Prognosis; S Phase; Time Factors; Uterine Cervical Neoplasms | 2006 |
Noninvasive monitoring of radiotherapy-induced microvascular changes using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in a colorectal tumor model.
Topics: Animals; Capillary Permeability; Cell Hypoxia; Cell Line, Tumor; Colorectal Neoplasms; Contrast Media; Heterocyclic Compounds; Magnetic Resonance Imaging; Male; Microcirculation; Models, Animal; Nitroimidazoles; Organometallic Compounds; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Rats; Vascular Endothelial Growth Factor A | 2006 |
An immunohistochemical assessment of hypoxia in prostate carcinoma using pimonidazole: implications for radioresistance.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Cell Hypoxia; Humans; Immunohistochemistry; Male; Middle Aged; Nitroimidazoles; Prostatic Neoplasms; Radiation-Sensitizing Agents | 2006 |
Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia.
Topics: Animals; Female; Gene Expression; Hypoxia-Inducible Factor 1; Immunohistochemistry; Male; Myocardial Ischemia; Myocardium; Nitroimidazoles; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sex Characteristics; Ventricular Remodeling | 2006 |
Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Analysis of Variance; Biomarkers; Carbonic Anhydrases; Cell Hypoxia; Colonic Neoplasms; ErbB Receptors; Female; Humans; Idoxuridine; Male; Microcirculation; Middle Aged; Nitroimidazoles; Observer Variation; Rectal Neoplasms; Vascular Endothelial Growth Factor A | 2006 |
Hypoxia-inducible factors and tubular cell survival in isolated perfused kidneys.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Survival; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kidney Tubules, Collecting; Nitroimidazoles; Oxygen; Perfusion; Rats; Up-Regulation | 2006 |
Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Fluorine Radioisotopes; Glioblastoma; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radionuclide Imaging | 2006 |
Microsatellite alterations in head and neck squamous cell carcinoma and relation to expression of pimonidazole, CA IX and GLUT-1.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Base Sequence; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Excitatory Amino Acid Transporter 2; Female; Head and Neck Neoplasms; Humans; Immunohistochemistry; Loss of Heterozygosity; Male; Microsatellite Instability; Middle Aged; Molecular Sequence Data; Nitroimidazoles | 2006 |
Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients.
Topics: Aged; Cell Hypoxia; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Treatment Outcome | 2006 |
Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Female; Humans; Imaging, Three-Dimensional; Male; Mice; Mice, Nude; Nitroimidazoles; Prognosis; Treatment Outcome; Xenograft Model Antitumor Assays | 2006 |
Oxygen status of lung granulomas in Mycobacterium tuberculosis-infected mice.
Topics: Animals; Biomarkers; Disease Models, Animal; Electrodes; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mice; Mice, Inbred C57BL; Mutation; Mycobacterium tuberculosis; Necrosis; Nitrates; Nitroimidazoles; Oxygen; Time Factors; Tuberculosis, Pulmonary | 2006 |
Rod photoreceptor loss in Rho-/- mice reduces retinal hypoxia and hypoxia-regulated gene expression.
Topics: Animals; Apyrase; Cyclic Nucleotide Phosphodiesterases, Type 6; Dark Adaptation; Diltiazem; Enzyme-Linked Immunosorbent Assay; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Light; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Oxygen Consumption; Phosphoric Diester Hydrolases; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Retinal Vessels; Reverse Transcriptase Polymerase Chain Reaction; Rhodopsin; RNA, Messenger; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2006 |
Age-related hearing loss in CD/1 mice is associated to ROS formation and HIF target proteins up-regulation in the cochlea.
Topics: Action Potentials; Aging; Animals; Apoptosis; Caspase 3; Cochlea; Cochlear Nerve; Coloring Agents; Hearing Loss; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Injections, Intravenous; Insulin-Like Growth Factor I; Mice; Nitroimidazoles; Reactive Oxygen Species; Schwann Cells; Spiral Ganglion; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53; Up-Regulation | 2007 |
Detecting changes in tumor hypoxia with carbonic anhydrase IX and pimonidazole.
Topics: Animals; Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Humans; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Oxygen Consumption | 2007 |
Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue.
Topics: Biological Transport; Cell Culture Techniques; Diffusion; Finite Element Analysis; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Hydrogels; Indoles; Models, Cardiovascular; Myocardium; Myocytes, Cardiac; Nitroimidazoles; Oxygen; Oxygen Consumption; Tissue Engineering | 2007 |
Tacrolimus (FK506) limits accumulation of granulocytes and platelets and protects against brain damage after transient focal cerebral ischemia in rat.
Topics: Animals; Blood Platelets; Brain Ischemia; Cell Adhesion; Cerebral Cortex; Granulocytes; Infarction, Middle Cerebral Artery; Intercellular Adhesion Molecule-1; Male; Microtubule-Associated Proteins; Neuroprotective Agents; Nitroimidazoles; Rats; Rats, Wistar; Tacrolimus | 2007 |
Rat epigastric flap survival and VEGF expression after local copper application.
Topics: Abdominal Wall; Administration, Topical; Animals; Cell Hypoxia; Copper; Graft Survival; Immunohistochemistry; Male; Necrosis; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Surgical Flaps; Vascular Endothelial Growth Factors; Wound Healing | 2007 |
Improved cryosections and specific immunohistochemical methods for detecting hypoxia in mouse and rat cochleae.
Topics: Animals; Animals, Outbred Strains; Biomarkers; Cochlear Diseases; Fluorescent Antibody Technique, Indirect; Frozen Sections; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Nitroimidazoles; Rats; Rats, Sprague-Dawley; Tissue Embedding | 2007 |
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia.
Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Differentiation; Hematopoietic Stem Cells; Hematopoietic System; Hypoxia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Stem Cells; Tirapazamine; Triazines | 2007 |
Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Capillary Permeability; Cell Hypoxia; Cell Movement; Gene Expression Regulation; Granulocytes; Hematopoietic Stem Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred Strains; Nitroimidazoles; Oxygen Consumption; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A | 2007 |
Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
Topics: Alanine Transaminase; Animals; Antithrombins; Cathepsin G; Cathepsins; CD18 Antigens; Fibrin; Fibrinogen; Hemostasis; Hypochlorous Acid; Immune Sera; Leukocyte Count; Lipopolysaccharides; Liver; Male; Models, Biological; Neutrophils; Nitroimidazoles; Pancreatic Elastase; Plasminogen Activator Inhibitor 1; Proteins; Ranitidine; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors; Thrombin | 2007 |
Location of persisting mycobacteria in a Guinea pig model of tuberculosis revealed by r207910.
Topics: Animals; Antibiotics, Antitubercular; Antitubercular Agents; Colony Count, Microbial; Diarylquinolines; Female; Granuloma; Guinea Pigs; Hypoxia; Isoniazid; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Pyrazinamide; Quinolines; Radiation-Sensitizing Agents; Rifampin; Spleen; Tuberculosis | 2007 |
Conformational exchange in pimonidazole--a hypoxia marker.
Topics: Animals; Biomarkers; Cell Hypoxia; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Neoplasms; Nitroimidazoles | 2007 |
Hypoxia in prostate cancer: correlation of BOLD-MRI with pimonidazole immunohistochemistry-initial observations.
Topics: Aged; Cell Hypoxia; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitroimidazoles; Oxygen; Prostatectomy; Prostatic Neoplasms; Radiation-Sensitizing Agents; Staining and Labeling | 2007 |
Development of cytosolic hypoxia and hypoxia-inducible factor stabilization are facilitated by aquaporin-1 expression.
Topics: Animals; Aquaporin 1; Carbon Dioxide; Cell Membrane; Cytosol; Gene Expression Regulation; Hypoxia; Hypoxia-Inducible Factor 1; Lung; Microscopy, Confocal; Models, Biological; Nitroimidazoles; Oxygen; PC12 Cells; Permeability; Rats; Up-Regulation | 2007 |
Immunohistochemical detection of hypoxia in mouse liver tissues treated with pimonidazole using "in vivo cryotechnique".
Topics: Animals; Cryopreservation; Freeze Substitution; Hypoxia; Immunohistochemistry; Injections, Intraperitoneal; Liver; Mice; Mice, Inbred C57BL; Nitroimidazoles; Tissue Fixation | 2007 |
Tumour cell proliferation under hypoxic conditions in human head and neck squamous cell carcinomas.
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Proliferation; Female; Head and Neck Neoplasms; Humans; Idoxuridine; Image Processing, Computer-Assisted; Male; Middle Aged; Neoplasm Staging; Neovascularization, Pathologic; Nitroimidazoles; Nucleic Acid Synthesis Inhibitors; Radiation-Sensitizing Agents; Treatment Outcome | 2008 |
Effects of old age on hepatocyte oxygenation.
Topics: Aging; Animals; Biomarkers; Hepatocytes; Hypoxia; Male; Mitochondria; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Inbred F344 | 2007 |
Identifying and targeting hypoxia in head and neck cancer: a brief overview of current approaches.
Topics: Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Electrodes; Etanidazole; Head and Neck Neoplasms; Humans; Hydrocarbons, Fluorinated; Intracellular Signaling Peptides and Proteins; Mitochondrial Proteins; Neoplasm Proteins; Nitroimidazoles; Osteopontin; Oxygen; Partial Pressure; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 2007 |
Hypoxic changes in the central nervous system of noise-exposed mice.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Brain; Cell Hypoxia; Ear, Inner; Fluorescent Antibody Technique; Hearing Loss, Noise-Induced; Mice; Mice, Inbred BALB C; Nitroimidazoles; Noise; Radiation-Sensitizing Agents | 2007 |
Hypoxia can be detected in irradiated normal human tissue: a study using the hypoxic marker pimonidazole hydrochloride.
Topics: Adult; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Female; Humans; Middle Aged; Nitroimidazoles; Radiation Injuries; Radiotherapy, High-Energy; United Kingdom | 2007 |
Adaptation to hypoxia in the diabetic rat kidney.
Topics: Adaptation, Physiological; Animals; Antioxidants; Basic Helix-Loop-Helix Transcription Factors; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glomerular Filtration Rate; Heme Oxygenase-1; Hypoxia; Hypoxia-Inducible Factor 1; Insulin; Male; Nitroimidazoles; Rats; Rats, Inbred Strains; Spin Labels; Streptozocin | 2008 |
Expression of hypoxia-inducible factor 1alpha in mononuclear phagocytes infected with Leishmania amazonensis.
Topics: Animals; Cadmium Chloride; Cell Hypoxia; Cells, Cultured; Dendritic Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Leishmania mexicana; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitroimidazoles | 2007 |
Measurement of hypoxia using invasive oxygen-sensitive electrode, pimonidazole binding and 18F-FDG uptake in anaemic or erythropoietin-treated mice bearing human glioma xenografts.
Topics: Anemia; Animals; Autoradiography; Electrodes; Erythropoietin; Fluorodeoxyglucose F18; Glioma; Hemoglobins; Humans; Hypoxia; Mice; Mice, Nude; Muscle, Skeletal; Neoplasm Transplantation; Nitroimidazoles; Recombinant Proteins; Transplantation, Heterologous | 2008 |
Experimental evaluation of functional imaging for radiotherapy.
Topics: Animals; Biomarkers, Tumor; Dose Fractionation, Radiation; Fluorodeoxyglucose F18; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Neoplastic Stem Cells; Nitroimidazoles; Positron-Emission Tomography; Proportional Hazards Models; Radiation-Sensitizing Agents; Radiopharmaceuticals; Radiotherapy; Radiotherapy Dosage; Xenograft Model Antitumor Assays | 2007 |
Testosterone-stimulated growth of the rat prostate may be driven by tissue hypoxia and hypoxia-inducible factor-1alpha.
Topics: Animals; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Epithelial Cells; ErbB Receptors; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Neovascularization, Physiologic; Nitroimidazoles; Orchiectomy; Prostate; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Testosterone; Vascular Endothelial Growth Factor A | 2008 |
Imaging hypoxia in xenografted and murine tumors with 18F-fluoroazomycin arabinoside: a comparative study involving microPET, autoradiography, PO2-polarography, and fluorescence microscopy.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Fibrosarcoma; Fluorine Radioisotopes; Immunocompromised Host; Immunohistochemistry; Mice; Mice, Inbred C3H; Mice, Nude; Microscopy, Fluorescence; Nitroimidazoles; Oxygen; Polarography; Positron-Emission Tomography; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2008 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Immunohistochemistry; Lung; Macaca fascicularis; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mycobacterium tuberculosis; Nitroimidazoles; Oxygen; Rabbits; Radiation-Sensitizing Agents; Tuberculosis, Pulmonary | 2008 |
Hypoxia, hypoxia-inducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis.
Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Carotid Stenosis; Cross-Sectional Studies; Disease Progression; Endarterectomy, Carotid; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Immunohistochemistry; Macrophages; Male; Middle Aged; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; RNA, Messenger; Vascular Endothelial Growth Factor A | 2008 |
The paradox of hypoxic and oxidative stress in atherosclerosis.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Atherosclerosis; Biomarkers; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Macrophages; Neovascularization, Pathologic; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species | 2008 |
Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome: in regard to Evans et al. (Int J Radiat Oncol Biol Phys 2007;69:1024-1031).
Topics: Carbon Dioxide; Carcinoma, Squamous Cell; Cell Hypoxia; Head and Neck Neoplasms; Humans; Nitroimidazoles; Oxygen; Prognosis; Radiation-Sensitizing Agents; Time Factors | 2008 |
Correlation of [18F]FMISO autoradiography and pimonidazole [corrected] immunohistochemistry in human head and neck carcinoma xenografts.
Topics: Animals; Autoradiography; Biomarkers, Tumor; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Misonidazole; Nitroimidazoles; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity | 2008 |
Importance of antibody concentration in the assessment of cellular hypoxia by flow cytometry: EF5 and pimonidazole.
Topics: Animals; Area Under Curve; Calibration; Cell Hypoxia; Cell Line, Tumor; Etanidazole; Flow Cytometry; Humans; Hydrocarbons, Fluorinated; Kinetics; Microscopy, Fluorescence; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Time Factors | 2008 |
Changes in tumor hypoxia induced by mild temperature hyperthermia as assessed by dual-tracer immunohistochemistry.
Topics: Adenocarcinoma; Analysis of Variance; Animals; Cell Hypoxia; Colorectal Neoplasms; Etanidazole; Female; Hydrocarbons, Fluorinated; Hyperthermia, Induced; Immunohistochemistry; Mice; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2008 |
Imaging hypoxia in orthotopic rat liver tumors with iodine 124-labeled iodoazomycin galactopyranoside PET.
Topics: Animals; Carcinoma, Hepatocellular; Hypoxia; Image Processing, Computer-Assisted; Iodine Radioisotopes; Liver Neoplasms; Monosaccharides; Nitroimidazoles; Positron-Emission Tomography; Rats; Rats, Nude | 2008 |
Resolution in PET hypoxia imaging: voxel size matters.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Mice; Mice, Nude; Microscopy, Fluorescence; Necrosis; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography | 2008 |
Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer.
Topics: Animals; Cell Hypoxia; Cell Movement; Cell Proliferation; Culture Media, Conditioned; Fibrosis; Humans; Neovascularization, Pathologic; Nitroimidazoles; Pancreatic Neoplasms; Vascular Endothelial Growth Factor A | 2008 |
Perindopril attenuates tubular hypoxia and inflammation in an experimental model of diabetic nephropathy in transgenic Ren-2 rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Fibrosis; Hypoxia; Immunohistochemistry; Inflammation; Kidney Tubules; Macrophages; Nitroimidazoles; Osteopontin; Perindopril; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Time Factors | 2008 |
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous | 2008 |
Effect of artificial oxygen carrier with chemotherapy on tumor hypoxia and neovascularization.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Cricetinae; HeLa Cells; Hemoglobins; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mesocricetus; Microvessels; Neoplasms, Experimental; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Oxygen Inhalation Therapy; Polyethylene Glycols; Tumor Burden | 2008 |
Detection of different hypoxic cell subpopulations in human melanoma xenografts by pimonidazole immunohistochemistry.
Topics: Animals; Cell Hypoxia; Female; Frozen Sections; Humans; Immunohistochemistry; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Nitroimidazoles; Paraffin Embedding; Transplantation, Heterologous | 2008 |
No detectable hypoxia in malignant salivary gland tumors: preliminary results.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Proliferation; Deoxyuridine; Glucose Transporter Type 1; Glucose Transporter Type 2; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Middle Aged; Nitroimidazoles; Salivary Gland Neoplasms | 2009 |
An exploratory study into the role of dynamic contrast-enhanced magnetic resonance imaging or perfusion computed tomography for detection of intratumoral hypoxia in head-and-neck cancer.
Topics: Aged; Biomarkers, Tumor; Carbonic Anhydrases; Cell Hypoxia; Contrast Media; Female; Head and Neck Neoplasms; Humans; Iohexol; Magnetic Resonance Imaging; Male; Middle Aged; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Statistics, Nonparametric; Tomography, Spiral Computed | 2009 |
Influence of PEG-conjugated hemoglobin on tumor oxygenation and response to chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Substitutes; Cisplatin; Drug Synergism; Female; Hemoglobins; Hypoxia; Mice; Mice, Inbred BALB C; Nitroimidazoles; Oxygen Consumption; Polyethylene Glycols; Treatment Outcome; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2008 |
HMG-CoA reductase inhibitors (statin) prevents retinal neovascularization in a model of oxygen-induced retinopathy.
Topics: Animals; Blotting, Western; Capillaries; Disease Models, Animal; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Indoles; Infant, Newborn; Intercellular Adhesion Molecule-1; Lipid Peroxidation; Mice; Nitroimidazoles; Oxygen; Phosphorylation; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; STAT3 Transcription Factor; Superoxides; Vascular Endothelial Growth Factor A | 2009 |
Expression of hemoglobin in rodent neurons.
Topics: Animals; Antibodies, Monoclonal; Cell Hypoxia; Cells, Cultured; Cerebellum; Cerebral Cortex; Electrophoresis, Gel, Two-Dimensional; Erythropoietin; Female; Hemoglobins; Hippocampus; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nitroimidazoles; Oxygen; Rats; Rats, Wistar; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity | 2009 |
Pimonidazole adduct immunohistochemistry in the rat kidney: detection of tissue hypoxia.
Topics: Animals; Hypoxia; Immunohistochemistry; Kidney; Molecular Structure; Nitroimidazoles; Rats; Tissue Fixation | 2009 |
Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.
Topics: Animals; Autoradiography; Cell Hypoxia; Disease Models, Animal; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Rats | 2009 |
Immunohistochemical detection of changes in tumor hypoxia.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carbon Dioxide; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 2009 |
Radio-copper-labeled Cu-ATSM: an indicator of quiescent but clonogenic cells under mild hypoxia in a Lewis lung carcinoma model.
Topics: Animals; Autoradiography; Bromodeoxyuridine; Carcinoma, Lewis Lung; Cell Proliferation; Colony-Forming Units Assay; Coordination Complexes; Copper Radioisotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Hypoxia; Image Processing, Computer-Assisted; Immunohistochemistry; Ki-67 Antigen; Male; Mice; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Staining and Labeling; Thiosemicarbazones | 2009 |
Serum factors potentiate hypoxia-induced hepatotoxicity in vitro through increasing transforming growth factor-beta1 activation and release.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Cell Hypoxia; Cell Line; Cell Survival; Gene Expression; Hepatocytes; Hyaluronan Receptors; L-Lactate Dehydrogenase; Matrix Metalloproteinase 9; Nitroimidazoles; Phosphorylation; Proliferating Cell Nuclear Antigen; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type I; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Serum; Smad2 Protein; Transforming Growth Factor beta1 | 2009 |
Increased hypoxia following vessel targeting in a murine model of retinoblastoma.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Carboplatin; Disease Models, Animal; Hypoxia; Mice; Mice, Transgenic; Microscopy, Confocal; Neovascularization, Pathologic; Nitroimidazoles; Pregnadienediols; Retinal Neoplasms; Retinoblastoma | 2009 |
Core needle biopsies for determination of the microenvironment in individual tumours for longitudinal radiobiological studies.
Topics: Animals; Biopsy, Needle; Carcinoma, Squamous Cell; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Environment; Female; Humans; Hypoxia; Immunohistochemistry; Longitudinal Studies; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Probability; Radiobiology; Random Allocation; Reference Values | 2009 |
Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Carcinoma, Squamous Cell; Cell Hypoxia; Female; Humans; Immunohistochemistry; Laryngeal Neoplasms; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents | 2009 |
Atrasentan (ABT-627) enhances perfusion and reduces hypoxia in a human tumor xenograft model.
Topics: Adenocarcinoma; Animals; Atrasentan; Colonic Neoplasms; Combined Modality Therapy; Etanidazole; Gadolinium DTPA; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Nitroimidazoles; Perfusion; Pyrrolidines; Radiation-Sensitizing Agents; Radiotherapy; Treatment Outcome; Xenograft Model Antitumor Assays | 2009 |
Can hypoxia-PET map hypoxic cell density heterogeneity accurately in an animal tumor model at a clinically obtainable image contrast?
Topics: Animals; Carcinoma, Squamous Cell; Cell Count; Cell Hypoxia; Disease Models, Animal; Female; Hypoxia; Mice; Mice, Inbred C3H; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Random Allocation; Sensitivity and Specificity; Tissue Distribution | 2009 |
pO(2)-dependent NO production determines OPPC activity in macrophages.
Topics: Amidines; Animals; Benzylamines; Cell Hypoxia; Cell Line; Disulfides; Ethanol; Feedback, Physiological; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; NADP; Nitric Oxide; Nitric Oxide Synthase Type II; Nitroimidazoles; Oxidants; Oxidative Stress; Oxygen; Pentose Phosphate Pathway | 2010 |
Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.
Topics: Animals; Benzimidazoles; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Female; Fluorescent Dyes; Glucose; Humans; Hypoxia; Lactic Acid; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Transplantation, Heterologous | 2009 |
Detection of hypoxia in microscopic tumors using 131I-labeled iodo-azomycin galactopyranoside (131I-IAZGP) digital autoradiography.
Topics: Animals; Antigens, Neoplasm; Autoradiography; Biological Transport; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; Female; Galactosides; Humans; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles; Radioactive Tracers; Radiographic Image Enhancement | 2010 |
Immunohistochemical detection of tumour hypoxia.
Topics: Animals; Glucose Transporter Type 1; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Neoplasms; Nitroimidazoles | 2010 |
Role of hypoxia-inducible factor 1alpha in T cells as a negative regulator in development of vascular remodeling.
Topics: Animals; Antibody Formation; Arteriosclerosis; Cell Hypoxia; Cell Proliferation; Chemokine CXCL12; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Femoral Artery; Hyperplasia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunity, Cellular; Immunohistochemistry; Lymphocyte Activation; Male; Mice; Mice, Knockout; Nitroimidazoles; Receptors, Antigen, T-Cell; T-Lymphocytes; Thymus Gland; Time Factors; Tunica Intima | 2010 |
Intrinsic susceptibility MR imaging of chemically induced rat mammary tumors: relationship to histologic assessment of hypoxia and fibrosis.
Topics: Animals; Biomarkers, Tumor; Carbon Dioxide; Female; Fibrosis; Hypoxia; Keratin-14; Linear Models; Magnetic Resonance Imaging; Mammary Neoplasms, Experimental; Methylnitrosourea; Necrosis; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Rats; Rats, Wistar | 2010 |
Improved methodology for identifying the teratogenic potential in early drug development of hERG channel blocking drugs.
Topics: Abnormalities, Drug-Induced; Animals; Astemizole; Cetirizine; Drug Evaluation, Preclinical; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Rate; Histamine H1 Antagonists, Non-Sedating; Hypoxia; Image Processing, Computer-Assisted; Maternal Exposure; Nitroimidazoles; Potassium Channels, Inwardly Rectifying; Pregnancy; Rats; Rats, Sprague-Dawley; Teratogens | 2010 |
Preliminary study on the effect of trauma-induced secondary cellular hypoxia in brain injury.
Topics: Animals; Biomarkers; Cell Hypoxia; Cerebral Cortex; Head Injuries, Closed; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Male; Nitroimidazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Transforming Growth Factor beta1 | 2010 |
Development of hypoxia in a preclinical model of tumor micrometastases.
Topics: Animals; Blood Flow Velocity; Cell Hypoxia; Female; Humans; Melanoma; Mice; Mice, Inbred A; Mice, Nude; Nitroimidazoles; Rhodamines; Xenograft Model Antitumor Assays | 2010 |
Stretch-induced uterine myocyte differentiation during rat pregnancy: involvement of caspase activation.
Topics: Animals; Caspase 3; Cell Differentiation; Enzyme Induction; Female; Gestational Age; Gravidity; Hypoxia-Inducible Factor 1, alpha Subunit; Myocytes, Smooth Muscle; Myometrium; Nitroimidazoles; Pregnancy; Rats; Rats, Wistar; Stress, Mechanical; Uterus | 2010 |
High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia.
Topics: Air; Animals; Autoradiography; Biological Transport; Carbon Dioxide; Cell Proliferation; Female; Fluorescent Antibody Technique; Fluorodeoxyglucose F18; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HT29 Cells; Humans; Hypoxia; Mice; Nitroimidazoles; Oxygen; Peritoneal Neoplasms; Respiration | 2010 |
Chorioretinal ischemia and angiogenic milieu following photodynamic therapy.
Topics: Angiogenic Proteins; Animals; Biomarkers; Cytokines; Fluorescent Antibody Technique, Indirect; Hypoxia-Inducible Factor 1, alpha Subunit; Ischemia; Microscopy, Confocal; Nitroimidazoles; Photochemotherapy; Photosensitizing Agents; Porphyrins; Rats; Rats, Inbred BN; Retinal Diseases; Retinal Vessels; Somatomedins; Vascular Endothelial Growth Factor A; Verteporfin | 2010 |
Carbon dioxide pneumoperitoneum, intraperitoneal pressure, and peritoneal tissue hypoxia: a mouse study with controlled respiratory support.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Female; Hypoxia-Inducible Factor 1; Immunohistochemistry; Laparotomy; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Peritoneal Cavity; Peritoneum; Plant Proteins; Pneumoperitoneum, Artificial; Pressure; Respiration, Artificial; Tissue Adhesions | 2010 |
Correlating quantitative MR measurements of standardized tumor lines with histological parameters and tumor control dose.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; Lactic Acid; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Radiation Dosage; Radiation-Sensitizing Agents; Sensitivity and Specificity; Transplantation, Heterologous | 2010 |
PET of hypoxia with 89Zr-labeled cG250-F(ab')2 in head and neck tumors.
Topics: Animals; Antibodies, Monoclonal; Autoradiography; Carbonic Anhydrase Inhibitors; Head and Neck Neoplasms; Hypoxia; Image Processing, Computer-Assisted; Immunoglobulin Fab Fragments; Immunoglobulin G; Immunohistochemistry; Isotope Labeling; Mice; Mice, Inbred BALB C; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Quality Control; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tissue Distribution; Xenograft Model Antitumor Assays; Zirconium | 2010 |
Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation.
Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Cell Hypoxia; Confidence Intervals; Disease Models, Animal; Dose Fractionation, Radiation; Dose-Response Relationship, Radiation; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiobiology; Transplantation, Heterologous; Tumor Microenvironment | 2010 |
Irradiation-dependent effects on tumor perfusion and endogenous and exogenous hypoxia markers in an A549 xenograft model.
Topics: Adenocarcinoma; Animals; Apoptosis; Benzimidazoles; Biomarkers; Caspase 3; Cell Hypoxia; Contrast Media; Gadolinium; Glucose Transporter Type 1; Humans; Lung Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Nude; Microscopy, Fluorescence; Nitroimidazoles; Platelet Endothelial Cell Adhesion Molecule-1; Time Factors; Transplantation, Heterologous | 2010 |
Effect of cetuximab and fractionated irradiation on tumour micro-environment.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Combined Modality Therapy; Dose Fractionation, Radiation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Male; Mice; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Signal Transduction; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2010 |
Focal, periocular delivery of 2-deoxy-D-glucose as adjuvant to chemotherapy for treatment of advanced retinoblastoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Deoxyglucose; Disease Models, Animal; Drug Delivery Systems; Hypoxia; Mice; Mice, Transgenic; Microscopy, Fluorescence; Nitroimidazoles; Retinal Neoplasms; Retinoblastoma; Tumor Burden | 2010 |
Comparative study of tumor hypoxia by diffuse optical spectroscopy and immunohistochemistry in two tumor models.
Topics: Animals; Biomarkers, Tumor; Brain Neoplasms; Diffusion; Disease Models, Animal; Female; Hemoglobins; Hypoxia; Immunohistochemistry; Lymph Nodes; Male; Medical Oncology; Nitroimidazoles; Optical Devices; Oxygen; Radiation-Sensitizing Agents; Rats; Spectrum Analysis | 2010 |
Evaluation of the radiosensitivity of the oxygenated tumor cell fractions in quiescent cell populations within solid tumors.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Radiation; Female; Gamma Rays; Lymphoma; Mice; Mice, Inbred C57BL; Micronucleus Tests; Nitroimidazoles; Oxygen; Radiation Tolerance | 2010 |
Testing for hypoxia in forearm skin of patients with systemic sclerosis, assessed by pimonidazole.
Topics: Adult; Aged; Female; Forearm; Humans; Hypoxia; Male; Middle Aged; Nitroimidazoles; Radiation-Sensitizing Agents; Scleroderma, Systemic; Skin | 2010 |
Evaluation of renal hypoxia in diabetic mice by BOLD MRI.
Topics: Age Factors; Animals; Diabetic Nephropathies; Hypoxia; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Staining and Labeling | 2010 |
Hypoxia in models of lung cancer: implications for targeted therapeutics.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Electrodes; Histones; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Neoplasms, Experimental; Nitrogen Mustard Compounds; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Proto-Oncogene Proteins c-myc; ras Proteins | 2010 |
Acetaminophen hepatotoxicity and HIF-1α induction in acetaminophen toxicity in mice occurs without hypoxia.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Cyclosporine; Dose-Response Relationship, Drug; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunosuppressive Agents; Male; Mice; Mice, Inbred C57BL; Mitochondria, Liver; Nitroimidazoles; Oxidative Stress; Statistics, Nonparametric | 2011 |
Metabolic correlates of tumour hypoxia in malignant canine mammary carcinoma.
Topics: Animals; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Immunohistochemistry; Mammary Neoplasms, Animal; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Staining and Labeling | 2011 |
Differences in breast tissue oxygenation following radiotherapy.
Topics: Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Female; Humans; Hyperbaric Oxygenation; Middle Aged; Nitroimidazoles; Oxygen; Skin | 2011 |
Detection of hypoxia by [18F]EF5 in atherosclerotic plaques in mice.
Topics: Analysis of Variance; Animals; Aorta; Apolipoprotein B-100; Atherosclerosis; Autoradiography; Disease Models, Animal; Etanidazole; Female; Fluorine Radioisotopes; Genotype; Hydrocarbons, Fluorinated; Hypoxia; Immunohistochemistry; Insulin-Like Growth Factor II; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitroimidazoles; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, LDL; Tissue Distribution | 2011 |
Quantitative assessment of hypoxia subtypes in microcirculatory supply units of malignant tumors using (immuno-)fluorescence techniques.
Topics: Benzimidazoles; Cell Hypoxia; Cell Line, Tumor; Diffusion; Humans; Microcirculation; Microscopy, Fluorescence; Microvessels; Neoplasms; Nitroimidazoles; Perfusion Imaging; Prognosis; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2011 |
Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Dose Fractionation, Radiation; Humans; Mice; Mice, Nude; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2011 |
Trichinella spiralis infection induces angiogenic factor thymosin β4 expression.
Topics: Animals; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Muscle, Skeletal; Nitroimidazoles; Thymosin; Trichinella spiralis; Trichinellosis; Vascular Endothelial Growth Factor A | 2011 |
Perfusion estimated with rapid dynamic contrast-enhanced magnetic resonance imaging correlates inversely with vascular endothelial growth factor expression and pimonidazole staining in head-and-neck cancer: a pilot study.
Topics: Aged; Algorithms; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Contrast Media; Female; Head and Neck Neoplasms; Humans; Kinetics; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Neoplasm Proteins; Neovascularization, Pathologic; Nitroimidazoles; Pilot Projects; Real-Time Polymerase Chain Reaction; Tumor Burden; Vascular Endothelial Growth Factor A | 2011 |
Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Cycle Proteins; Cell Hypoxia; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; Head and Neck Neoplasms; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Monocarboxylic Acid Transporters; Muscle Proteins; Neoplasm Staging; Neovascularization, Pathologic; Nitroimidazoles; Oncogene Proteins; Protein Transport; Proteins | 2011 |
Scaffold porosity and oxygenation of printed hydrogel constructs affect functionality of embedded osteogenic progenitors.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Hypoxia; Cell Proliferation; Cell Survival; Goats; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Implants, Experimental; Mice; Mice, Nude; Multipotent Stem Cells; Nitroimidazoles; Osteogenesis; Porosity; Tissue Engineering; Tissue Scaffolds | 2011 |
Vasculatures in tumors growing from preirradiated tissues: formed by vasculogenesis and resistant to radiation and antiangiogenic therapy.
Topics: Angiogenesis Inhibitors; Animals; Bone Marrow Transplantation; Cell Aggregation; Cell Hypoxia; Cell Line, Tumor; Coloring Agents; Drug Resistance, Neoplasm; Endothelial Cells; Green Fluorescent Proteins; Indoles; Macrophages; Male; Mice; Mice, Inbred C57BL; Neoplasm Recurrence, Local; Neoplasms, Radiation-Induced; Neovascularization, Pathologic; Nitroimidazoles; Prostatic Neoplasms; Pyrroles; Radiation Dosage; Radiation Tolerance; Radiation-Sensitizing Agents; Salvage Therapy; Sunitinib; Tumor Burden; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2011 |
Mycobacterium tuberculosis infection induces hypoxic lung lesions in the rat.
Topics: Animals; Disease Models, Animal; Female; Granuloma; Hypoxia; Immunohistochemistry; Lung; Mycobacterium tuberculosis; Nitroimidazoles; Rats; Tuberculosis, Pulmonary | 2011 |
Dynamic contrast-enhanced-MRI of tumor hypoxia.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Contrast Media; Female; Gadolinium DTPA; Humans; Image Enhancement; Image Processing, Computer-Assisted; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sensitivity and Specificity; Whole Body Imaging | 2012 |
Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cinnamates; Female; Fluorodeoxyglucose F18; Glucose; Glycolysis; Head and Neck Neoplasms; Immunoenzyme Techniques; Lactates; Linear Models; Luminescent Measurements; Mice; Mice, Nude; Monocarboxylic Acid Transporters; Nitroimidazoles; Oxidation-Reduction; Symporters; Tumor Microenvironment; Uterine Cervical Neoplasms | 2011 |
Increased numbers of low-oxygenated pancreatic islets after intraportal islet transplantation.
Topics: Animals; Apoptosis; Caspase 3; Graft Survival; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Liver; Male; Mice; Nitroimidazoles; Oxygen | 2011 |
A low-oxygenated subpopulation of pancreatic islets constitutes a functional reserve of endocrine cells.
Topics: Animals; Cell Respiration; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Nitroimidazoles; Oxygen; Pancreas; Pancreatectomy; Protein Biosynthesis; Rats; Rats, Inbred WF; Tissue Culture Techniques | 2011 |
Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia-inducible factor-1-active regions in a tumor: comparison among single-photon emission computed tomography/X-ray computed tomography imaging, autoradiography, and immunohistochemistry.
Topics: Animals; Autoradiography; Biotin; Female; Fluorescent Antibody Technique, Direct; Hypoxia-Inducible Factor 1, alpha Subunit; Iodine Radioisotopes; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Neoplasm Proteins; Nitroimidazoles; Radiopharmaceuticals; Recombinant Fusion Proteins; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2011 |
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.
Topics: Animals; Brain; Disease Models, Animal; Erythropoietin; Female; Fluorescent Dyes; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Malaria, Cerebral; Mice; Nitroimidazoles; Parasitemia; Plasmodium berghei; Poly(ADP-ribose) Polymerases; Survival Analysis; Treatment Outcome | 2011 |
Preclinical evaluation and validation of [18F]HX4, a promising hypoxia marker for PET imaging.
Topics: Animals; Biomarkers; Cell Hypoxia; Fluorine Radioisotopes; Imidazoles; Male; Neoplasms, Experimental; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Triazoles | 2011 |
Liposomal doxorubicin improves radiotherapy response in hypoxic prostate cancer xenografts.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Contrast Media; Doxorubicin; Humans; Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Theoretical; Neoplasm Transplantation; Nitroimidazoles; Prostatic Neoplasms; Treatment Outcome | 2011 |
HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.
Topics: Animals; Blister; Body Fluids; Cell Hypoxia; Disease Models, Animal; Ear, Middle; Gene Expression Regulation; Hearing Loss; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indoles; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Nitroimidazoles; Otitis Media with Effusion; Phthalazines; Pyridines; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Sunitinib; Vascular Endothelial Growth Factor A | 2011 |
pO₂ fluctuation pattern and cycling hypoxia in human cervical carcinoma and melanoma xenografts.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Coloring Agents; Connective Tissue; Female; Humans; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2012 |
Evaluation of novel combined carbogen USPIO (CUSPIO) imaging biomarkers in assessing the antiangiogenic effects of cediranib (AZD2171) in rat C6 gliomas.
Topics: Angiogenesis Inhibitors; Animals; Benzimidazoles; Biomarkers, Tumor; Contrast Media; Dextrans; Fluorescent Dyes; Glioma; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Nitroimidazoles; Quinazolines; Radiation-Sensitizing Agents; Rats; Rats, Nude; Tumor Cells, Cultured | 2012 |
Conductive thermal ablation of 4T1 murine breast carcinoma reduces severe hypoxia in surviving tumour.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Hypoxia; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Nitroimidazoles; Radiation-Sensitizing Agents | 2012 |
Dynamic contrast-enhanced magnetic resonance imaging of the metastatic potential of melanoma xenografts.
Topics: Animals; Biomarkers, Tumor; Cell Hypoxia; Contrast Media; Female; Gadolinium DTPA; Humans; Lung; Lung Neoplasms; Magnetic Resonance Imaging; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Transplantation, Heterologous; Tumor Microenvironment | 2012 |
Expression of EGFR under tumor hypoxia: identification of a subpopulation of tumor cells responsible for aggressiveness and treatment resistance.
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Cell Survival; Disease-Free Survival; ErbB Receptors; Head and Neck Neoplasms; Humans; Nitroimidazoles; Prognosis; Radiation Tolerance; Radiation-Sensitizing Agents | 2012 |
Operable non-small cell lung cancer: correlation of volumetric helical dynamic contrast-enhanced CT parameters with immunohistochemical markers of tumor hypoxia.
Topics: Aged; Biomarkers, Tumor; Blood Volume; Carcinoma, Non-Small-Cell Lung; Contrast Media; Female; Humans; Hypoxia; Immunohistochemistry; Iohexol; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Grading; Neoplasm Staging; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiographic Image Interpretation, Computer-Assisted; Statistics, Nonparametric; Tomography, Spiral Computed | 2012 |
(64)Cu-ATSM and (18)FDG PET uptake and (64)Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry.
Topics: Animals; Autoradiography; Carcinoma; Cell Hypoxia; Coordination Complexes; Copper Radioisotopes; Dogs; Fluorodeoxyglucose F18; Immunohistochemistry; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiopharmaceuticals; Sarcoma; Thiosemicarbazones | 2012 |
Tumor microenvironment-dependent 18F-FDG, 18F-fluorothymidine, and 18F-misonidazole uptake: a pilot study in mouse models of human non-small cell lung cancer.
Topics: Animals; Biological Transport; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Mice; Misonidazole; Necrosis; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radioactive Tracers; Tumor Microenvironment | 2012 |
Copper-64-diacetyl-bis(N(4)-methylthiosemicarbazone) pharmacokinetics in FaDu xenograft tumors and correlation with microscopic markers of hypoxia.
Topics: Animals; Autoradiography; Biomarkers; Carcinoma, Squamous Cell; Cell Hypoxia; Coordination Complexes; Head and Neck Neoplasms; Humans; Immunohistochemistry; Muscles; Nitroimidazoles; Organometallic Compounds; Partial Pressure; Radionuclide Imaging; Rats; Rats, Nude; Thiosemicarbazones; Tissue Distribution; Transplantation, Heterologous; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
In vivo visualization of heterogeneous intratumoral distribution of hypoxia-inducible factor-1α activity by the fusion of high-resolution SPECT and morphological imaging tests.
Topics: Animals; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Iodine Radioisotopes; Magnetic Resonance Imaging; Mice; Mice, Inbred C3H; Molecular Imaging; Molecular Probes; Neoplasms, Experimental; Nitroimidazoles; Tissue Distribution; Tomography, Emission-Computed, Single-Photon | 2012 |
Enhanced radiosensitization by liposome-encapsulated pimonidazole for anticancer effects on human melanoma cells.
Topics: Cell Line; Cell Survival; Humans; Liposomes; Materials Testing; Melanoma; Nanocapsules; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 2012 |
Evaluation of the relationship between MR estimates of blood oxygen saturation and hypoxia: effect of an antiangiogenic treatment on a gliosarcoma model.
Topics: Analysis of Variance; Angiogenesis Inhibitors; Animals; Benzenesulfonates; Brain Neoplasms; Dextrans; Gliosarcoma; Hypoxia, Brain; Image Processing, Computer-Assisted; Immunohistochemistry; Linear Models; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Niacinamide; Nitroimidazoles; Oxygen; Phenylurea Compounds; Pyridines; Random Allocation; Rats; Rats, Inbred F344; Reproducibility of Results; Sorafenib | 2012 |
Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck.
Topics: Animals; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; ErbB Receptors; Fluorescent Antibody Technique; Head and Neck Neoplasms; Heterocyclic Compounds, 3-Ring; Humans; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Radiation-Sensitizing Agents; Radiotherapy; Receptor, ErbB-2; Signal Transduction; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2012 |
Prognostic value of HIF-1α expression during fractionated irradiation.
Topics: Animals; Biomarkers, Tumor; Blotting, Western; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Dose Fractionation, Radiation; Female; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Otorhinolaryngologic Neoplasms; Prognosis; Radiation-Sensitizing Agents; Statistics as Topic; Transplantation, Heterologous | 2012 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease Progression; Drug Resistance; Epilepsy; HMGB1 Protein; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Interneurons; Male; Nerve Tissue Proteins; Neuropeptide Y; Nitroimidazoles; Parvalbumins; Pilocarpine; Rats; Rats, Sprague-Dawley; Recurrence; Seizures; Status Epilepticus | 2013 |
Wortmannin efficiently suppresses the recovery from radiation-induced damage in pimonidazole-unlabeled quiescent tumor cell population.
Topics: Androstadienes; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Survival; DNA Damage; Drug Interactions; Drug Synergism; Lymphoma; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Staining and Labeling; Treatment Outcome; Wortmannin | 2013 |
Dynamics of tumor hypoxia in response to patupilone and ionizing radiation.
Topics: Animals; Biomarkers, Tumor; Cell Death; Cell Hypoxia; Cell Line, Tumor; Cobalt; Combined Modality Therapy; Epothilones; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Luciferases; Mice; Mice, Nude; Neoplasms; Nitroimidazoles; Oxygen; Partial Pressure; Protein Structure, Tertiary; Radiation, Ionizing; Xenograft Model Antitumor Assays | 2012 |
Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction.
Topics: Animals; Boron Neutron Capture Therapy; Carbon; Cell Line, Tumor; Gamma Rays; Heavy Ion Radiotherapy; Lymphoma; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy, High-Energy; Treatment Outcome | 2013 |
Biological characteristics of intratumoral [F-18]‑fluoromisonidazole distribution in a rodent model of glioma.
Topics: Animals; Autoradiography; Biological Transport; Brain Neoplasms; Cell Hypoxia; Cell Proliferation; Fluorodeoxyglucose F18; Glioma; Glucose; Glucose Transporter Type 1; Hexokinase; Hypoxia-Inducible Factor 1; Ki-67 Antigen; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Wistar; Tissue Distribution | 2013 |
Chronic activation of vasopressin V2 receptor signalling lowers renal medullary oxygen levels in rats.
Topics: Animals; Deamino Arginine Vasopressin; Disease Models, Animal; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney Medulla; Nitroimidazoles; Oxygen; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Vasopressins | 2013 |
Determination of organ-specific anemia tolerance.
Topics: Acute Disease; Anemia; Animals; Brain; Cell Hypoxia; Female; Hemodilution; Hemodynamics; Hypoxia; Hypoxia, Brain; Immune Tolerance; Intestine, Small; Kidney; Liver; Male; Muscle, Skeletal; Nitroimidazoles; Oxygen Consumption; Random Allocation; Swine; Vascular Endothelial Growth Factor A | 2013 |
Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice.
Topics: Adipose Tissue; Alleles; Animals; Bone Marrow Cells; Cell Polarity; Flow Cytometry; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Nitroimidazoles; Phenotype | 2013 |
The teratogenic effect of dofetilide during rat limb development and association with drug-induced bradycardia and hypoxia in the embryo.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Heart; Hypoxia; Limb Deformities, Congenital; Nitroimidazoles; Phenethylamines; Rats; Rats, Sprague-Dawley; Sulfonamides; Teratogens | 2013 |
Remote post-conditioning reduces hypoxic damage early after experimental stroke.
Topics: Animals; Blotting, Western; Disease Models, Animal; Femoral Vein; Hypoxia, Brain; Male; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Wistar; Reperfusion Injury; Stroke | 2013 |
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment.
Topics: Animals; Bone Marrow; Cell Cycle; Cell Hypoxia; Cellular Microenvironment; Colony-Forming Units Assay; Femur; Flow Cytometry; Hematopoietic Stem Cells; Hypoxia-Inducible Factor 1, alpha Subunit; Image Processing, Computer-Assisted; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Nitroimidazoles; Spleen; Stem Cell Factor | 2013 |
Pronounced hypoxia in the subventricular zone following traumatic brain injury and the neural stem/progenitor cell response.
Topics: Animals; Brain Injuries; Cell Hypoxia; Cell Proliferation; Cells, Cultured; Cerebral Ventricles; Ephrin-B3; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Neural Stem Cells; Nitroimidazoles; Receptor, EphB3; Signal Transduction; Stem Cell Transplantation | 2013 |
Evaluation and immunohistochemical qualification of carbogen-induced ΔR₂ as a noninvasive imaging biomarker of improved tumor oxygenation.
Topics: Animals; Biomarkers; Carbon Dioxide; Cell Hypoxia; Immunohistochemistry; Magnetic Resonance Imaging; Mice; Nitroimidazoles; Oxygen; Oxygen Consumption; Partial Pressure; Pituitary Neoplasms; Prolactinoma | 2013 |
Synergistic effect of combination topotecan and chronomodulated radiation therapy on xenografted human nasopharyngeal carcinoma.
Topics: Animals; Carcinoma; Cell Hypoxia; Chronotherapy; Combined Modality Therapy; DNA Damage; DNA Topoisomerases, Type I; Dose-Response Relationship, Radiation; Histones; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Recurrence, Local; Nitroimidazoles; Phosphorylation; Radiation Tolerance; Radiation-Sensitizing Agents; Time Factors; Topoisomerase I Inhibitors; Topotecan; Transplantation, Heterologous | 2013 |
Hypoxia and visualization of the stem cell niche.
Topics: Animals; Biomarkers; Cell Hypoxia; Humans; Immunohistochemistry; Indicators and Reagents; Mice; Nitroimidazoles; Oxidation-Reduction; Staining and Labeling; Stem Cell Niche | 2013 |
PET imaging of tumor hypoxia using 18F-labeled pimonidazole.
Topics: Animals; Carcinoma, Squamous Cell; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, Inbred C3H; Mice, Nude; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured | 2013 |
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression.
Topics: Adenosine Triphosphate; Base Sequence; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Humans; Macrophages; Molecular Sequence Data; Mycobacterium tuberculosis; Nitrates; Nitrites; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Sequence Analysis, RNA | 2013 |
DCE-MRI of the hypoxic fraction, radioresponsiveness, and metastatic propensity of cervical carcinoma xenografts.
Topics: Animals; Cell Hypoxia; Cell Survival; Contrast Media; Female; Gadolinium DTPA; Humans; Lymphatic Metastasis; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Intrahepatic microcirculatory disorder, parenchymal hypoxia and NOX4 upregulation result in zonal differences in hepatocyte apoptosis following lipopolysaccharide- and D-galactosamine-induced acute liver failure in rats.
Topics: Aldehydes; Animals; Apoptosis; Caspase 3; Disease Models, Animal; Fluconazole; Galactosamine; Hepatocytes; Hypoxia-Inducible Factor 1; Lipopolysaccharides; Liver; Liver Failure, Acute; Macrophages; Male; Microcirculation; NADPH Oxidase 4; NADPH Oxidases; Nitroimidazoles; Oxidative Stress; Rats; Rats, Wistar; Rhodamines; Up-Regulation | 2014 |
Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation.
Topics: Amines; Animals; Bromodeoxyuridine; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Nucleus; Dose Fractionation, Radiation; Electron Transport Complex I; Female; Heterografts; Humans; Hypoxia-Inducible Factor 1; Ki-67 Antigen; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Tumor Microenvironment | 2014 |
Renal oxygenation in acute renal ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Biomarkers; Cell Hypoxia; Disease Models, Animal; Fluorescence; Glomerular Filtration Rate; Hemoglobins; Immunohistochemistry; Kidney; Laser-Doppler Flowmetry; Male; Models, Cardiovascular; Nitroimidazoles; Oxygen; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Renal Circulation; Reperfusion Injury; Reproducibility of Results; Severity of Illness Index; Time Factors | 2014 |
Targeting breast tumors with pH (low) insertion peptides.
Topics: Animals; Blood Glucose; Cell Line, Tumor; Deoxyglucose; Drug Delivery Systems; Female; Hydrogen-Ion Concentration; Immunohistochemistry; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactates; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microscopy, Fluorescence; Neoplasm Transplantation; Nitroimidazoles; Peptides; Time Factors | 2014 |
Hyperoxia reverses glucotoxicity-induced inhibition of insulin secretion in rat INS-1 β cells.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Cell Line; Dose-Response Relationship, Drug; Drosophila Proteins; Gene Expression Regulation; Glucokinase; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 2; Homeodomain Proteins; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ion Channels; Mitochondrial Proteins; Nitroimidazoles; Oxygen; Rats; Trans-Activators; Uncoupling Protein 2 | 2014 |
Molecular probes for imaging of hypoxia in the retina.
Topics: Animals; Cell Line; Cell Survival; Fluorescein-5-isothiocyanate; Humans; Hypoxia; Mice; Molecular Imaging; Molecular Probes; Nitroimidazoles; Retina; Retinal Neurons | 2014 |
Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area.
Topics: Animals; Cell Hypoxia; Coloring Agents; Hemoglobins; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Microvessels; Muscle, Skeletal; Nitroimidazoles; Oxygen; Rats, Wistar; Wounds, Nonpenetrating | 2014 |
The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer.
Topics: Cell Hypoxia; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Nitroimidazoles; Proportional Hazards Models; Prostatic Neoplasms; Staining and Labeling; Tissue Distribution; Transcriptome | 2015 |
Chemotherapy Rescues Hypoxic Tumor Cells and Induces Their Reoxygenation and Repopulation-An Effect That Is Inhibited by the Hypoxia-Activated Prodrug TH-302.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line, Tumor; Cell Survival; Docetaxel; Doxorubicin; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles; Phosphoramide Mustards; Prodrugs; Taxoids; Xenograft Model Antitumor Assays | 2015 |
The reverse Warburg effect and 18F-FDG uptake in non-small cell lung cancer A549 in mice: a pilot study.
Topics: Animals; Blood Glucose; Body Weight; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Diet; Female; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radiopharmaceuticals; Tumor Microenvironment | 2015 |
Immunohistochemical evidence of stress and inflammatory markers in mouse models of cutaneous leishmaniosis.
Topics: Animals; Biomarkers; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Immunohistochemistry; Inflammation; Leishmania; Leishmaniasis, Cutaneous; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Nitric Oxide; Nitroimidazoles; p38 Mitogen-Activated Protein Kinases; Vascular Endothelial Growth Factor A | 2015 |
Combretastatin A4 phosphate treatment induces vasculogenic mimicry formation of W256 breast carcinoma tumor in vitro and in vivo.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mammary Neoplasms, Animal; Neovascularization, Pathologic; Nitroimidazoles; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction; Stilbenes | 2015 |
Preclinical and Clinical Evidence of Mycobacterium tuberculosis Persistence in the Hypoxic Niche of Bone Marrow Mesenchymal Stem Cells after Therapy.
Topics: Adapalene; Animals; Antitubercular Agents; Bone Marrow Cells; Cell Hypoxia; Down-Regulation; Female; Green Fluorescent Proteins; Humans; Isoniazid; Lung; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Radiation-Sensitizing Agents; Specific Pathogen-Free Organisms; Tuberculosis, Pulmonary; Up-Regulation | 2015 |
64Cu-ATSM Hypoxia Positron Emission Tomography for Detection of Conduit Ischemia in an Experimental Rat Esophagectomy Model.
Topics: Anastomotic Leak; Animals; Autoradiography; Coordination Complexes; Copper Radioisotopes; Esophagectomy; Esophagogastric Junction; Gastric Fundus; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Ischemia; Male; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Thiosemicarbazones | 2015 |
The Effects of Pulsed Radiation Therapy on Tumor Oxygenation in 2 Murine Models of Head and Neck Squamous Cell Carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Heterografts; Mice; Mice, Nude; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tumor Burden | 2015 |
Assessment of hypoxic subvolumes in laryngeal cancer with (18)F-fluoroazomycinarabinoside ((18)F-FAZA)-PET/CT scanning and immunohistochemistry.
Topics: Aged; Aged, 80 and over; Biomarkers; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Hypoxia; Laryngeal Neoplasms; Laryngectomy; Male; Middle Aged; Multimodal Imaging; Neoplasm Recurrence, Local; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tomography, X-Ray Computed | 2015 |
Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia.
Topics: Animals; Biomarkers, Tumor; Blood Vessels; Cell Hypoxia; Cell Line, Tumor; Contrast Media; Female; Imaging, Three-Dimensional; Mammary Neoplasms, Experimental; Mice; Microbubbles; Molecular Imaging; Nitroimidazoles; Stromal Cells; Ultrasonography | 2015 |
Mass Spectrometry Imaging of the Hypoxia Marker Pimonidazole in a Breast Tumor Model.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Humans; Nitroimidazoles; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Histological Image Processing Features Induce a Quantitative Characterization of Chronic Tumor Hypoxia.
Topics: Algorithms; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hypoxia; Image Processing, Computer-Assisted; Mice; Mice, Nude; Nitroimidazoles | 2016 |
RRx-001, an epigenetic-based radio- and chemosensitizer, has vascular normalizing effects on SCCVII and U87 tumors.
Topics: Actins; Animals; Antineoplastic Agents; Azetidines; Cell Hypoxia; Cell Line, Tumor; Epigenesis, Genetic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neoplasm Transplantation; Neoplasms; Nitro Compounds; Nitroimidazoles; Tumor Microenvironment | 2016 |
Cerebral and extracerebral vulnerability to hypoxic insults after diffuse traumatic brain injury in rats.
Topics: Animals; Arterial Pressure; Brain; Brain Injuries, Traumatic; Disease Models, Animal; Hypotension; Hypoxia; Hypoxia, Brain; Kidney; Liver; Male; Myocardium; Nitroimidazoles; Rats; Rats, Sprague-Dawley | 2016 |
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment | 2016 |
Quantitative [
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mammary Neoplasms, Animal; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Receptor, ErbB-2; Trastuzumab; Tumor Burden; Tumor Hypoxia | 2017 |
Imaging Mass Spectrometry Revealed the Accumulation Characteristics of the 2-Nitroimidazole-Based Agent "Pimonidazole" in Hypoxia.
Topics: Animals; Cell Hypoxia; Glutathione; Humans; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Nitroimidazoles | 2016 |
Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.
Topics: Animals; Animals, Newborn; Blotting, Western; Disease Models, Animal; Galectin 1; Gene Silencing; Hypoxia; Intravitreal Injections; Ischemia; Mice; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Real-Time Polymerase Chain Reaction; Retinal Neovascularization; RNA; RNA, Messenger | 2017 |
Assessment of intratumor hypoxia by integrated 18F-FDG PET / perfusion CT in a liver tumor model.
Topics: Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Glucose; Humans; Hypoxia; Liver Neoplasms; Male; Neovascularization, Pathologic; Nitroimidazoles; Oxygen Consumption; Perfusion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Rabbits | 2017 |
Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Line, Tumor; Contrast Media; Female; Head and Neck Neoplasms; Humans; Lymph Nodes; Magnetic Resonance Imaging; Male; Mice; Neovascularization, Pathologic; Nitroimidazoles; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Xenograft Model Antitumor Assays | 2017 |
Maternal nutrient restriction in guinea pigs leads to fetal growth restriction with evidence for chronic hypoxia.
Topics: Animals; Cohort Studies; Erythropoietin; Female; Fetal Development; Fetal Growth Retardation; Guinea Pigs; Hypoxia; Immunohistochemistry; Male; Maternal Nutritional Physiological Phenomena; Maternal-Fetal Exchange; Nitroimidazoles; Placenta; Pregnancy; Signal Transduction; Vascular Endothelial Growth Factor A | 2017 |
Altered glucose metabolism and hypoxic response in alloxan-induced diabetic atherosclerosis in rabbits.
Topics: Alloxan; Animals; Apoptosis; Atherosclerosis; Autoradiography; Body Weight; Cluster Analysis; Diabetes Mellitus, Experimental; Diet, High-Fat; Electrophoresis, Capillary; Femoral Artery; Fluorodeoxyglucose F18; Glucose; Glycolysis; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Macrophages; Mass Spectrometry; Metabolomics; Microscopy, Fluorescence; Nitroimidazoles; Principal Component Analysis; Rabbits | 2017 |
Dynamic contrast-enhanced MRI of the microenvironment of pancreatic adenocarcinoma xenografts.
Topics: Animals; Carcinoma, Pancreatic Ductal; Contrast Media; Extracellular Fluid; Female; Heterocyclic Compounds; Heterografts; Humans; Hypoxia; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Neoplasm Transplantation; Nitroimidazoles; Organometallic Compounds; Pancreatic Neoplasms; Platelet Endothelial Cell Adhesion Molecule-1; Pressure; Tumor Microenvironment | 2017 |
In Vivo Imaging of Retinal Hypoxia Using HYPOX-4-Dependent Fluorescence in a Mouse Model of Laser-Induced Retinal Vein Occlusion (RVO).
Topics: Animals; Disease Models, Animal; Fluorescein Angiography; Fluoresceins; Fluorescent Dyes; Hypoxia; Image Processing, Computer-Assisted; Macular Edema; Male; Mice; Mice, Inbred C57BL; Nitroimidazoles; Radiation-Sensitizing Agents; Retinal Neovascularization; Retinal Vein; Retinal Vein Occlusion; Tomography, Optical Coherence | 2017 |
Low-dose YC-1 combined with glucose and insulin selectively induces apoptosis in hypoxic gastric carcinoma cells by inhibiting anaerobic glycolysis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetyl Coenzyme A; Anaerobiosis; Animals; Apoptosis; Carcinoma; Cell Line, Tumor; Deoxyguanosine; Glucose; Glucose Transporter Type 1; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Insulin; Mice; Nitroimidazoles; Oxidative Phosphorylation; Stomach Neoplasms; Tumor Hypoxia; Xenograft Model Antitumor Assays | 2017 |
Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.
Topics: Animals; Contrast Media; Diffusion Magnetic Resonance Imaging; Female; Fibrosis; Humans; Mammary Neoplasms, Experimental; Necrosis; Nitroimidazoles; Platelet Endothelial Cell Adhesion Molecule-1; Rats, Sprague-Dawley | 2018 |
Evaluation of Vascularity, Blood Perfusion, and Oxygen Tension in Tumor Xenografts with Fluorescent Microscopy.
Topics: Animals; Disease Models, Animal; Fluorescent Antibody Technique; Heterografts; Humans; Hypoxia; Mice; Microscopy, Fluorescence; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Oxygen | 2018 |
Optical spectroscopic sensing of tumor hypoxia.
Topics: Animals; Biosensing Techniques; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Hemoglobins; Humans; Mice; Mice, Nude; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Spectrum Analysis; Tumor Cells, Cultured; Tumor Hypoxia | 2018 |
Fast and sensitive dynamic oxygen-enhanced MRI with a cycling gas challenge and independent component analysis.
Topics: Animals; Biomarkers; Biomarkers, Tumor; Cell Hypoxia; Cell Line, Tumor; Female; HCT116 Cells; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Oxygen; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment | 2019 |
Hyperthermia-triggered release of hypoxic cell radiosensitizers from temperature-sensitive liposomes improves radiotherapy efficacy in vitro.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemoradiotherapy; Dose-Response Relationship, Drug; Drug Compounding; Drug Stability; Humans; Hyperthermia, Induced; Hypopharyngeal Neoplasms; Liposomes; Nitroimidazoles; Radiation-Sensitizing Agents; Temperature | 2019 |
DCE-MRI and Quantitative Histology Reveal Enhanced Vessel Maturation but Impaired Perfusion and Increased Hypoxia in Bevacizumab-Treated Cervical Carcinoma.
Topics: Actins; Angiogenesis Inhibitors; Animals; Bevacizumab; Capillary Permeability; Contrast Media; Female; Heterografts; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Mice, Nude; Microvessels; Nitroimidazoles; Oxygen Consumption; Pericytes; Tumor Hypoxia; Tumor Microenvironment; Uterine Cervical Neoplasms | 2019 |
Residual gammaH2AX foci in head and neck squamous cell carcinomas as predictors for tumour radiosensitivity: Evaluation in pre-clinical xenograft models and clinical specimens.
Topics: Animals; Female; Head and Neck Neoplasms; Histones; Humans; Male; Mice; Nitroimidazoles; Radiation Tolerance; Radiotherapy Dosage; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2019 |
Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer.
Topics: Animals; Antigens, Neoplasm; Carbonic Anhydrase IX; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Glycogen; Histones; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Neoplasm Transplantation; Nitroimidazoles; Radiation Dosage; Spectrum Analysis, Raman; Treatment Outcome | 2019 |
ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines.
Topics: Animals; Antigens, Neoplasm; Biomarkers, Tumor; Carbonic Anhydrase IX; Cell Hypoxia; Cell Line, Tumor; HCT116 Cells; HeLa Cells; HT29 Cells; Humans; Membrane Glycoproteins; Mice; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Oxidoreductases | 2019 |
Improved Oxygen Supply to Multicellular Spheroids Using A Gas-permeable Plate and Embedded Hydrogel Beads.
Topics: Cell Nucleus; Cell Proliferation; Cytochrome P-450 CYP3A; DNA; Energy Metabolism; Gases; Gene Expression Regulation, Enzymologic; Glucose; Hep G2 Cells; Humans; Hydrogels; Ki-67 Antigen; Microspheres; Necrosis; Nitroimidazoles; Oxygen; Permeability; Spheroids, Cellular | 2019 |
Detection of cellular hypoxia by pimonidazole adduct immunohistochemistry in kidney disease: methodological pitfalls and their solution.
Topics: Acute Kidney Injury; Animals; Antibodies, Monoclonal; Antibody Specificity; Artifacts; Cell Hypoxia; Disease Models, Animal; False Positive Reactions; Immunohistochemistry; Kidney; Nitroimidazoles; Polycystic Kidney Diseases; Predictive Value of Tests; Rats, Inbred Lew; Rats, Sprague-Dawley; Renal Insufficiency, Chronic; Reperfusion Injury; Reproducibility of Results | 2019 |
Assessing Cellular Hypoxic Status In Situ Within the Bone Marrow Microenvironment.
Topics: Animals; Biomimetic Materials; Bone Marrow Cells; Cell Hypoxia; Glycolysis; Hematopoietic Stem Cells; Humans; Mice; Nitroimidazoles; Oxygen; Stem Cell Niche | 2019 |
Chronic exposure to hypoxia attenuates renal injury and innate immunity activation in the remnant kidney model.
Topics: Animals; Gene Expression Regulation; Hypoxia; Immunity, Innate; Kidney; Male; Nephrectomy; Nitroimidazoles; Organ Size; Oxygen; Radiation-Sensitizing Agents; Rats; Renal Insufficiency, Chronic | 2019 |
Effects of Photodynamic Therapy with Redaporfin on Tumor Oxygenation and Blood Flow in a Lung Cancer Mouse Model.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Kaplan-Meier Estimate; Lung Neoplasms; Mice, Inbred C57BL; Nitroimidazoles; Oxygen; Perfusion; Photochemotherapy; Porphyrins; Sulfonamides; Tissue Distribution; Tumor Hypoxia; Vascular Endothelial Growth Factor A | 2019 |
Radioiodination of Pimonidazole as a Novel Theranostic Hypoxia Probe.
Topics: Cell Hypoxia; Humans; Iodine Radioisotopes; Nitroimidazoles; Precision Medicine; Radiation-Sensitizing Agents; Radiopharmaceuticals | 2021 |
MRI Distinguishes Tumor Hypoxia Levels of Different Prognostic and Biological Significance in Cervical Cancer.
Topics: Algorithms; Animals; Cell Line, Tumor; Chemoradiotherapy; Contrast Media; Epithelial-Mesenchymal Transition; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression Profiling; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; M Phase Cell Cycle Checkpoints; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Nitroimidazoles; Oxidative Phosphorylation; Oxygen Consumption; Prognosis; Treatment Outcome; Tumor Hypoxia; Uterine Cervical Neoplasms | 2020 |
Detection of Hypoxic Regions in the Bone Microenvironment.
Topics: Animals; Blood Vessels; Bone and Bones; Cell Differentiation; Cell Hypoxia; Cellular Microenvironment; Hematopoietic Stem Cells; Homeostasis; Humans; Molecular Imaging; Nitroimidazoles; Oxygen; Stem Cell Niche | 2021 |
Correlation of Tumor Hypoxia Metrics Derived from
Topics: Animals; Benchmarking; Brain; Fluorescence; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Rats; Tumor Hypoxia | 2020 |
Detection of Low Oxygen Microenvironments in a Murine Model of Invasive Pulmonary Aspergillosis Using Pimonidazole.
Topics: Animals; Aspergillus fumigatus; Cell Hypoxia; Cellular Microenvironment; Disease Models, Animal; Fluorescent Antibody Technique; Host-Pathogen Interactions; Invasive Pulmonary Aspergillosis; Lung; Mice; Microscopy, Fluorescence; Nitroimidazoles; Oxygen | 2021 |
Hypoxia and pH co-triggered oxidative stress amplifier for tumor therapy.
Topics: Acrolein; Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Glutathione; Humans; Hydrogen-Ion Concentration; Mice; NADP; Neoplasms; Nitroimidazoles; Oxidative Stress; Reactive Oxygen Species; Tumor Hypoxia; Tumor Microenvironment | 2021 |
Assessment of hypoxia by pimonidazole staining following radiotherapy.
Topics: Biomarkers; Cell Hypoxia; Humans; Hypoxia; Neoplasms; Nitroimidazoles; Oxygen; Staining and Labeling; Tumor Microenvironment | 2022 |
Exploring Hypoxia in Prostate Cancer With T2-weighted Magnetic Resonance Imaging Radiomics and Pimonidazole Scoring.
Topics: Humans; Magnetic Resonance Imaging; Male; Nitroimidazoles; Prostate; Prostatic Neoplasms; Retrospective Studies | 2023 |
Persistence and expansion of hypoxia detected by pimonidazole adduct immunostaining during progression of diabetic nephropathy in diabetic mice.
Topics: Animals; Child, Preschool; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Nitroimidazoles | 2023 |