azomycin has been researched along with misonidazole in 641 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 552 (86.12) | 18.7374 |
| 1990's | 51 (7.96) | 18.2507 |
| 2000's | 18 (2.81) | 29.6817 |
| 2010's | 17 (2.65) | 24.3611 |
| 2020's | 3 (0.47) | 2.80 |
| Authors | Studies |
|---|---|
| Karim, AB | 1 |
| Kärcher, KH; Kogelnik, HD; Seitz, W; Szepesi, T | 1 |
| Anderson, P; Bleehen, N; Disch, S; Karcher, KH; Kogelnik, HD; Phillips, TL; Saunders, MI; Urtasun, RC; Wasserman, TH | 1 |
| Chapman, D; Koziol, D; Partington, J; Rabin, H; Urtasun, RC | 1 |
| Kuwabara, M; Washino, K; Yoshii, G | 1 |
| Gomer, CJ; Johnson, RJ; Lawrence, GA; Levin, VA; Marques, RA; Phillips, TL; Sadee, W; VanRaalte, G; Wasserman, TH | 1 |
| Anderson, P; Dische, S; Flockhart, IR; Lee, ME; Saunders, MI | 1 |
| Conger, AD; Pratt, NE; Sinesi, M; Sodicoff, M; Trepper, P | 1 |
| Kogelnik, HD; Mamoli, B; Müller, M; Rathkolb, O; Wessely, P | 1 |
| Bleehen, NM; Owen, LN; White, RA; Workman, P | 1 |
| Deys, BF; Stap, J | 1 |
| Flockhart, IR; Sheldon, PW; Stratford, IJ; Watts, ME | 1 |
| Mustea, I; Olinici, CD | 1 |
| Adams, GE; Clarke, ED; Gray, P; Jacobs, RS; Parrick, J; Smithen, CE; Stratford, IJ; Wallace, RG; Wardman, P; Watts, ME | 1 |
| Djordjevic, B | 1 |
| Bataini, JP; Bernier, J; Brugère, J; Brunin, F; de Narbonne, J; Jaulerry, C | 1 |
| Chomiczewski, J; Gałkiewicz, E; Górski, T; Pyziak, M | 1 |
| Brown, JM; Suit, HD | 1 |
| Hirst, DG; Hobson, B; Vojnovic, B | 1 |
| Overgaard, J | 3 |
| Bugden, RD; Peckham, MJ; Pedersen, JE; Smith, MR | 1 |
| Brustad, T; Rofstad, EK | 3 |
| Gomer, CJ; Johnson, RJ | 1 |
| Conroy, PJ; Passalacqua, W; Von Burg, R | 1 |
| Yuhas, JM | 1 |
| Berger, A; Brown, DM; Goldfeder, A | 1 |
| de Langen-Omri, F; Guichard, M; Malaise, EP | 1 |
| Brown, JM; Workman, P; Yu, NY | 1 |
| Conroy, PJ; Von Burg, R | 1 |
| Olive, PL | 1 |
| Bara, A; Mustea, I | 2 |
| Palcic, B; Skarsgard, LD; Skov, KA | 3 |
| Ash, DV; Bugden, RD; Smith, MR | 1 |
| Astor, M; Hall, EJ | 2 |
| Workman, P | 5 |
| Lindmo, T; Pettersen, EO; Wibe, E | 1 |
| Ash, DV; Smith, MR | 2 |
| Conroy, PJ; Passalacqua, W; Penney, DP; Sutherland, RM; Von Burg, R | 2 |
| Brown, JM; Yu, NY | 2 |
| Adams, GE; Dische, S | 1 |
| Bleehen, NM; Freedman, LS; Owen, LN; White, RA; Workman, P | 1 |
| Kubo, K; Nakanishi, YH; Utsumi, J; Yoshii, G | 1 |
| Ash, DV; Peckham, MJ; Steel, GG | 1 |
| Astor, M; August, L; Hall, EJ; Osmak, R; Shapiro, P | 1 |
| Stratford, IJ | 2 |
| Adams, GE; Stratford, IJ | 2 |
| Denekamp, J; McNally, NJ | 1 |
| Hall, EJ; Miller, RC | 2 |
| Clare, MG; Joslin, CA | 1 |
| Gulyas, S; Whitmore, GF; Wong, TW | 1 |
| Kauffman, SL; Rostom, AY; Steel, GG | 1 |
| Harris, JW; Shrieve, DC | 2 |
| Bleehen, NM; Plowman, PN; Wiltshire, CR; Workman, P | 1 |
| Stratford, MR | 1 |
| Breborowicz, H; Rybczynska, M; Simon, M | 1 |
| Hodgkiss, RJ; Kelleher, E; Parrick, J | 1 |
| Chapman, JD; Roa, WH | 1 |
| Adams, GE; Bedwell, J; Bown, SG; Bremner, JC; MacRobert, AJ; Pearson, JK; Phillips, D; Sansom, JM; Stratford, IJ | 1 |
| Beningo, KA; Elliott, WL; Heffner, TG; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Vincent, PW; Wiley, JN | 1 |
| Moore, SK; Wallen, CA; Wheeler, KT | 1 |
| Chapman, JD; McPhee, MS; Santus, R; Stobbe, CC | 1 |
| Cohen, GM; Cullis, P; Holley, J; Mather, A; Symons, MR; Wardman, P; Watt, RA | 1 |
| Chaplin, DJ | 1 |
| Adams, GE; Bremner, JC; Cole, S; Edwards, HS; Stratford, IJ | 1 |
| Chaplin, DJ; Horsman, MR | 1 |
| Adams, GE; Cole, S; Elliott, W; Fielden, EM; Leopold, W; Sebolt-Leopold, J; Stratford, IJ; Suto, M | 1 |
| Bando, M; Hori, H; Inayama, S; Nagasawa, H; Onoyama, Y; Satoh, T; Tada, T | 1 |
| Binger, M; Workman, P | 1 |
| Wallen, CA; Wheeler, KT; Wong, KH | 2 |
| Arundel-Suto, CM; Elliott, WE; Leopold, WR; Sebolt-Leopold, JS; Stier, MA; Suto, MJ; Werbel, LM | 1 |
| Watts, ME; Woodcock, M | 2 |
| Dennis, MF; Roberts, IJ; Watts, ME | 1 |
| Rybczynska, M | 1 |
| Adams, GE; Bremner, JC; Edwards, HS; Fielden, EM; Stratford, IJ | 1 |
| Adams, GE; Bowler, J; Cole, S; Lorimore, SA; Nolan, J; Stratford, IJ; Wright, EG | 1 |
| Herman, TS; Holden, SA; Jones, SM; Pfeffer, MR; Teicher, BA | 1 |
| Abe, M; Hori, H; Inayama, S; Nagasawa, H; Sasai, K; Shibamoto, Y; Shibata, T; Takahashi, M; Zhou, L | 1 |
| Chapnick, RM; Herman, TS; Kalick, GS; Khandekar, V; Pfeffer, MR; Rabow, A; Teicher, BA | 1 |
| Mori, T; Murayama, C | 3 |
| Church, DL; Laishley, EJ; Rabin, HR | 1 |
| Butler, SA; Cobb, LM; Nolan, J | 1 |
| DeGraff, WG; Gamson, J; Mitchell, JB; Russo, A | 1 |
| Calderwood, SK; Coleman, CN; Stevenson, MA | 1 |
| Hall, EJ; Hei, TK | 1 |
| Hickson, ID; Robson, CN; Stephens, M; Stratford, IJ | 1 |
| Mori, T | 1 |
| Herman, TS; Holden, SA; Jones, SM; Teicher, BA | 1 |
| Miyata, Y; Mori, T; Murayama, C; Sakaguchi, M; Suzuki, A; Suzuki, T; Tanabe, Y; Tanaka, N | 1 |
| Abe, M; Kagiya, T; Nishimoto, S; Sasai, K; Shibamoto, Y; Takahashi, M; Wang, J; Zhou, L | 1 |
| Allalunis-Turner, J; Applebaum, FR; Chapman, JD; Deeg, HJ; Graham, T; Shields, AF; Storb, R | 1 |
| Korbelik, M; Palcic, B; Skarsgard, LD | 2 |
| Griffiths, JR; Maxwell, RJ; Workman, P | 1 |
| Roberts, IJ; Watts, ME; Woodcock, M | 1 |
| Barascut, JL; Carminati, A; Gipp, JJ; Imbach, JL; Mulcahy, RT | 1 |
| Chapman, JD; Kanclerz, A | 1 |
| Egolf, RA; Fitzpatrick, DA; Heindel, ND; Walton, H | 1 |
| Hofer, KG; Hofer, MG; Lakkis, M | 1 |
| Astor, MB; Biaglow, JE; Clark, EP; Epp, ER; Hall, EJ; Roizen-Towle, L; Varnes, ME | 1 |
| Bazin, M; Moreno, G; Salet, C; Santus, R | 1 |
| Hill, RP | 1 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Orchard, RA; Saunders, MI; Stratford, MR | 1 |
| Minchinton, AI; Stratford, MR | 1 |
| Biaglow, JE; Clark, EP; Donahue, LL; Epp, ER; Tuttle, SW; Varnes, ME | 1 |
| Ling, CC; Schell, MC; Spiro, IJ; Stickler, R | 1 |
| Abe, M; Fushiki, M; Nishidai, T; Ono, K; Sasai, K; Shibamoto, Y; Takahashi, M; Tsutsui, K | 1 |
| Bleehen, NM; Walton, MI; Workman, P | 1 |
| Inch, WR; Jacobson, EA; Tustanoff, ER | 1 |
| Boegman, RJ; Dragovic, L; Robertson, DM; Scarth, B | 1 |
| Brown, JM | 3 |
| Awschalom, M; Cohen, L; Hendrickson, FR; Kurup, PD; Mansell, J; Nelson, JS; Pajak, TF; Rosenberg, I; Ten Haken, RK | 1 |
| Lafleur, MV; Loman, AC; Loman, H; Plijmackers-Westmijze, EJ | 1 |
| Ganz, JC; Hagen, S; Hatlevoll, R; Kristiansen, K; Lindegaard, KF; Mella, O; Nesbakken, R; Ringkjöb, R; Rosengren, B; Torvik, A | 1 |
| Dischino, DD; Jerabek, PA; Kilbourn, MR; Patrick, TB; Welch, MJ | 1 |
| Blaschke, T; Coleman, CN; Cox, RS; Halsey, J; Hancock, S; Hirst, VK; Howes, AE; Pajak, T; Urtasun, RC; Wasserman, TH | 1 |
| Abe, M; Hori, H; Inayama, S; Kano, E; Ono, K; Shibamoto, Y; Shibata, T; Takahashi, M | 1 |
| Roizin-Towle, L | 1 |
| Coleman, CN | 1 |
| Dische, S | 3 |
| Fukuda, H; Hori, H; Inayama, S; Nakajima, T; Onoyama, Y; Sugimoto, K; Tanaka, M | 1 |
| Adams, GE; Ahmed, I; Fielden, EM; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR; Stratford, IJ | 1 |
| Edwards, DI; Knight, RC; Zahoor, A | 1 |
| Cheeseman, KH; Lee, FY; Workman, P | 1 |
| Salwińska, E; Suwiński, J; Watras, J; Wideł, M | 1 |
| Noker, PE; Simpson-Herren, L; Wagoner, SD | 1 |
| Adomat, H; Farrell, NP; Skov, KA | 1 |
| Franko, AJ; Fuciarelli, AF; Kelly, DA; Koch, CJ; Miller, GG; Raleigh, JA | 1 |
| Lee, FY; Workman, P | 5 |
| Lafleur, MV; Loman, H; Pluijmackers-Westmijze, EJ | 3 |
| Bennett, MH; Des Rochers, C; Dische, S; Dunphy, EP; Minchinton, AI; Saunders, MI; Stratford, MR; Wardman, P | 1 |
| Chan, PK; Farrell, NP; James, BR; Skov, KA | 1 |
| Ahmed, I; Jenkins, TC; McNeil, SS; O'Neill, P; Silver, AR | 1 |
| Hodgkiss, RJ | 1 |
| Geard, CR; Hall, EJ; Hei, TK; Osmak, RS | 1 |
| Edgren, M; Nishidai, T; Révész, L; Scott, OC | 1 |
| Moore, DE | 1 |
| Dennis, MF; Stratford, MR; Wardman, P; Watts, ME | 1 |
| Jones, NR; Watts, ME | 1 |
| Edgren, M; Révész, L | 1 |
| Chavaudra, N; Debieu, D; Deschavanne, PJ; Malaise, EP | 1 |
| Curry, B; Fulton, D; Geggie, PH; Johnson, E; Mielke, B; Muller, PJ; Shin, KH; Tanasichuk, H; Thomas, H; Urtasun, RC | 1 |
| Rose, GP; Taylor, JM | 1 |
| Mulcahy, RT; Siemann, DW | 2 |
| Lee, FY; Walton, MI; Workman, P | 1 |
| Hill, SA; Keng, PC; Maddison, K; Siemann, DW; Wolf, K | 1 |
| Denekamp, J; Randhawa, VS; Stewart, FA; Stratford, MR | 1 |
| Born, JL; Franko, AJ; Koch, CJ; Raleigh, JA | 1 |
| Remsen, JF | 1 |
| Albertsson, M; Håkansson, CH; Mercke, C; von Mecklenburg, C | 1 |
| Blasberg, R; Fenstermacher, J; Horowitz, M; Molnar, P; Owens, E; Patlak, C; Strong, J | 1 |
| Chin, L; Grunbaum, Z; Krohn, K; Nelson, N; Rasey, JS | 1 |
| Bauer, K; Conroy, PJ; Grunbaum, Z; Krohn, KA; Rasey, JS; Sutherland, RM | 1 |
| Arcangeli, G; Chaplain, G; Gonzalez, D; Horiot, JC; Svoboda, V; Van den Bogaert, W; van der Schueren, E; Van Tongelen, C | 1 |
| Mulcahy, RT | 2 |
| Born, JL; Hadley, WM | 1 |
| Albertsson, M; Håkansson, CH; Mercke, C | 1 |
| Hodgkiss, RJ; Middleton, RW | 2 |
| Brown, JM; Hazlehurst, JL; Hirst, DG | 3 |
| Inoue, H; Koizumi, H; Murata, M; Nakamura, M; Niibe, H; Tamura, M; Yonome, I | 1 |
| Gonzalez, DG; Maes, RA; Meering, PG; van Peperzeel, HA | 1 |
| Brailovsky, CA; Corcos, J; Elhilali, MM; Fathi, MA; Fisher, GJ; Nigam, VN; Pageau, R; Tahan, TW | 1 |
| Hattori, T; Hori, H; Igarashi, T; Inayama, S; Kitagawa, H; Noguchi, K; Satoh, T; Shibata, T; Ueno, K | 1 |
| Kandaiya, S | 1 |
| Meyn, RE; Murray, D | 4 |
| Ahmed, I; Jenkins, TC; Stratford, IJ | 1 |
| Fulton, DS; Geggie, PH; Johnson, E; Mielke, B; Moody, J; Muller, PJ; Shin, KH; Tanasichuk, H; Thomas, H; Urtasun, RC | 1 |
| Kärcher, KH; Kogelnik, HD; Stadler, B; Szepesi, T | 1 |
| Hansen, HS; Hansen, JM; Kamieniecka, Z; Køhler, O; Melgaard, B; Paulson, OB; Pedersen, AG; Tang, X; Trojaborg, W | 1 |
| Akhoush, H; Awwad, HK; Barsoum, M; El Badawy, S; el Baki, HA; El-Merzabani, M | 1 |
| Smith, RA | 2 |
| Varghese, AJ; Whitmore, GF | 7 |
| Edwards, DI; Knight, RC; Knox, RJ | 3 |
| Hall, EJ; Roizin-Towle, LA | 1 |
| Asbell, SO; Leibel, SA; Order, SE; Rominger, CJ | 1 |
| Bara, A; Mustea, I; Postescu, ID | 1 |
| Handa, H; Oda, Y; Ono, K; Otsuka, S; Suda, K; Takeuchi, J; Yamashita, J; Yumitori, K | 1 |
| Hall, EJ; Miller, RC; Osmak, R; Zimmerman, M | 1 |
| Doss, L; Johnson, R; Meoz, RT; Spanos, WJ; Wasserman, TH | 1 |
| Smith, BR | 1 |
| Ballon, SC; Coleman, CN; Halsey, J; Hirst, VK; Howes, AE; Martinez, A | 1 |
| Heller, EH; Mameghan, H | 1 |
| Mulcahy, RT; Siemann, DW; Sutherland, RM | 2 |
| Sinesi, MS; Stone, HB | 1 |
| Geard, CR; Rutledge-Freeman, MH; Spunberg, JJ | 1 |
| Neaderland, MH; Rockwell, S | 1 |
| Chaplin, DJ; Jinks, S; Millar, BC | 1 |
| Irvin, CG; Neaderland, MH; Rockwell, S | 1 |
| Abe, M; Hamanaka, D; Hiraoka, M; Nishidai, T; Ono, K; Takahashi, M | 1 |
| Brown, DM; Brown, JM; Dionet, C | 1 |
| Abe, M; Nishidai, T; Ono, K; Shibamoto, Y; Takahashi, M | 1 |
| Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
| Adams, GE | 3 |
| Brown, JM; Eifel, PJ | 1 |
| Battistella, R; McClelland, RA; Michaels, HB; Rauth, AM | 1 |
| Blanke, G; Luscher, G; Streffer, C; Tamulevicius, P | 1 |
| Hinchliffe, M; McNally, NJ | 1 |
| Coleman, CN; Phillips, TL; Urtasun, RC; Wasserman, TH | 1 |
| Denekamp, J; Fowler, JF; Williams, MV | 1 |
| Nelson, JS; VonGerichten, D; Wasserman, TH | 1 |
| Byhardt, RW; Cox, JD; Greenberg, M; Komaki, R | 1 |
| Gangji, D; Koziol, D; Partington, J; Phillips, TL; Schwade, JG; Strong, JM; Urtasun, R; Van Raalte, G; Wasserman, TH | 1 |
| Strike, TA; Walker, MD | 1 |
| Kogelnik, HD | 2 |
| Dische, S; Saunders, MI; Stratford, MR | 1 |
| Beaulieu, BB; Goldman, P; Koch, RL | 1 |
| Phillips, TL | 1 |
| Twentyman, PR | 2 |
| Johnson, RJ; Levin, VA; Phillips, TL; VanRaalte, G; Wasserman, TH | 1 |
| Brustad, T; Pettersen, EO; Rofstad, EK | 1 |
| Grigsby, P; Maruyama, Y | 1 |
| Dewar, AJ; Moffett, BJ; Rose, GP; Stratford, IJ | 1 |
| Denekamp, J; Rojas, A; Stewart, FA | 2 |
| Marten, TR | 1 |
| Black, BE; Bush, RS; Cummings, BJ; Rauth, AM; Sorenti, VL; Thomas, GM | 1 |
| Agboola, O; Feldstein, ML; Mielke, B; Miller, JD; Partington, J; Russell, DB; Tanasichuk, H; Urtasun, R | 1 |
| Glatstein, E; Makuch, RW; Schwade, JG; Strong, JM | 1 |
| Ando, K; Furukawa, S; Hiraoka, T; Kanai, T; Kawachi, K; Koike, S; Majima, H | 1 |
| Midander, J | 1 |
| McNally, NJ | 1 |
| Awwad, HK; Barsoum, M; El Badawy, S; El Baki, HA; El Merzabani, M; Ezzat, S; Omar, S; Zaki, A | 1 |
| Hansen, HH; Kjaer, M; Panduro, J; Wolff-Jensen, J | 1 |
| Hunter, N; Ito, H; Milas, L | 1 |
| Beach, JL; Grigsby, PW; Mendiondo, OA | 1 |
| Begg, AC; Terry, NH | 1 |
| Denekamp, J; Rojas, A | 1 |
| Abe, M; Dodo, Y; Hamanaka, D; Hiraoka, M; Nishidai, T; Ono, K; Takahashi, M | 1 |
| Tsukiyama, I | 1 |
| Awaad, HK; El Gammal, S; El-Merzabani, MM; Ghoneim, MA; Shaaban, AA | 1 |
| Denekamp, J; Williams, MV | 1 |
| Benkö, G; Gazsó, GL | 1 |
| Lubas, B; Sułkowska, A; Wilczok, T | 2 |
| Petin, VG | 1 |
| Anderson, RF; Patel, KB | 1 |
| Carabell, S; Goodman, RL; Nelson, DF; Nelson, JS; Schoenfeld, D; Wasserman, T; Weinstein, AS | 1 |
| Onoyama, Y | 1 |
| Davillas, N; Katsoyianni, C; Licourinas, M; Papavasiliou, C; Pappas, J; Seretakis, L; Stathopoulos, P; Thanos, A; Theodorou, C; Yiogarakis, D | 1 |
| Anderson, PJ; Bennett, MH; Dische, S; Saunders, MI | 1 |
| Siemann, DW | 3 |
| Abratt, RP; Barnes, DR; Hammond, JA; Sarembok, LA; Tucker, RD; Williams, AM | 1 |
| Cridland, S; Sealy, R | 1 |
| Davis, DR; Diener, MD; Gillespie, BW; Nelson, DF; Phillips, TL; Stetz, J; Wasserman, T | 1 |
| Demange, L; Froissart, D; Nguyen, TD; Panis, X | 1 |
| Ikeda, M; Irie, G; Kamata, R; Kaneda, K; Kikuchi, Y; Mikuriya, S; Mochizuki, S; Sakura, M; Sakurai, T; Watari, T | 1 |
| Dewar, AJ; Rose, GP; Stratford, IJ | 2 |
| Afzal, SM; Curtis, SB; Tenforde, TS | 1 |
| Rockwell, S | 1 |
| Salih, FM | 1 |
| Brown, JM; White, RA; Workman, P | 1 |
| Brown, DM; Brown, JM; Lee, WW; Yu, NY | 1 |
| Wasserman, TH | 1 |
| Abe, M; Dodo, Y; Nishidai, T; Ono, K; Takahashi, M | 1 |
| Brown, JM; Evans, JW; Horsman, MR | 1 |
| Skov, KA | 1 |
| Michaels, HB | 1 |
| de Ronde, J; Hinchliffe, M; McNally, NJ | 2 |
| Brown, DM; Goldfeder, A | 1 |
| Rauth, AM | 1 |
| Baer, KA; Koch, CJ; Stobbe, CC | 1 |
| Franko, AJ; Koch, CJ | 1 |
| Born, JL; Smith, BR | 1 |
| Clarke, C; Dawson, KB; Sheldon, PW; Simmons, DJ; Simpson, W | 1 |
| Edwards, MS; Gordon, DG; Levin, VA | 1 |
| Brown, DM; Coleman, CN; Halsey, J; Hirst, VK | 1 |
| Chao, CF; Johnson, RJ; Subjeck, JR; Ting, L | 1 |
| Irvin, CG; Nierenburg, M; Rockwell, S | 1 |
| Blekkenhorst, G; Cridland, S; Korrubel, J; Sealy, R | 1 |
| Brown, JM; Hsu, B; Sawyer, JM; Taylor, YC | 1 |
| Hill, SA; Keng, PC; Siemann, DW | 1 |
| Bauer, KD; Hill, SA; Keng, PC; Siemann, DW | 1 |
| Hill, SA; Siemann, DW | 1 |
| Adams, GE; Ahmed, I; Chaplin, DJ; Sheldon, PW | 1 |
| Fulton, DS; Raleigh, J; Tanasichuk, H; Urtasun, RC | 1 |
| Breccia, A; Busutti, L; Gattavecchia, E; Stagni, G | 1 |
| Edwards, MS; Gordon, DG; Levin, VA; Phillips, TL | 1 |
| Edwards, MS; Gordon, DG; Levin, VA; Phillips, TL; Salamy, A | 1 |
| Azzam, EI; Borsa, J; Einspenner, M; Raaphorst, GP; Sargent, MD | 1 |
| Faddegon, B; Palcic, B; Skarsgard, LD | 1 |
| Okajima, S; Okumura, Y | 1 |
| Williams, KM | 1 |
| Baumann, RA; Maes, RA; Meering, PG; Zijp, JJ | 1 |
| Haveman, J; Wondergem, J | 1 |
| Abe, Y; Hong, SS; Kaneta, K; Matsuzawa, T | 1 |
| Ide, H; Kagiya, T; Nishimoto, S; Ohkubo, O; Sakamoto, A; Wada, T | 1 |
| Mitsuhashi, N; Mogi, K; Nakajima, N; Niibe, H; Okazaki, A; Saito, K; Sakaino, K; Sudo, H; Suzuki, Y; Yonome, I | 1 |
| Yamashita, M | 1 |
| Denekamp, J; Middleton, RW; Minchinton, AI; Rojas, A; Smith, KA; Soranson, JA | 1 |
| Maezawa, H; Mori, T; Murayama, C; Ohizumi, Y | 2 |
| Biaglow, JE; Clark, EP; Epp, ER; Morse-Gaudio, M; Zachgo, E | 1 |
| Liu, SF; Raleigh, JA | 2 |
| Maddison, K; Siemann, DW; Wolf, K | 1 |
| Banerjee, R; Goldfeder, A; Mitra, J | 2 |
| Asakura, H; Kanazawa, A; Maruhashi, A; Mashima, Y | 1 |
| Hodgkiss, RJ; Jones, NR; Sehmi, DS; Watts, ME; Woodcock, M | 1 |
| Ide, H; Kagiya, T; Nishimoto, S; Wada, T | 1 |
| Khokhar, MT | 1 |
| Fuochi, PG; Gattavecchia, E; Tonelli, D | 1 |
| Hinchliffe, M; McNally, NJ; Stratford, MR | 1 |
| Chapman, JD; Garrecht, BM | 1 |
| Abe, Y; Hong, SS; Isobe, Y; Kaneta, K; Kawaguchi, T; Matsuzawa, T; Umegaki, Y; Yamakawa, M | 1 |
| Bleehen, NM; Jones, DH; Walton, MI; Workman, P | 1 |
| Bleehen, NM; Gleave, JR; Grant, RM; Hardy, DG; Holmes, AE; Jones, DH; Roberts, JT; Workman, P | 1 |
| Bleehen, NM; Jones, DH; Smith, NC; Workman, P | 1 |
| Cullen, B; Walker, H | 1 |
| Brown, DM; Brown, JM; Eifel, PJ; Lee, WW | 1 |
| Abd El Baki, H; Abd El Moneim, H; Awwad, HK; El Merzabani, M; Farag, HI; Omar, S | 1 |
| Martin, WM; McDermott, BJ; Murphy, RF; Van den Berg, HW | 1 |
| Hori, H; Inayama, S; Mori, T; Murayama, C | 2 |
| Lindmo, T; Pettersen, EO | 2 |
| Lehman, CM; Stewart, JR | 1 |
| Casanovas, AM; Labat, C; Malmary, MF; Oustrin, J; Patau, JP | 1 |
| Chapman, JD; Jette, DC; Wiebe, LI | 1 |
| Omura, M | 1 |
| Kishino, Y | 1 |
| Abe, M; Dodo, Y; Ono, K; Takahashi, M | 1 |
| Abe, M; Dodo, Y; Hiraoka, M; Jo, S; Nishidai, T; Ono, K; Takahashi, M | 1 |
| Okada, S; Sakamoto, K; Takada, C; Takahashi, M; Yasunaga, T | 1 |
| Baringer, RA; Bolger, C; Edwards, MS; Jewett, DL; Phillips, TL; Powers, SK | 1 |
| Baringer, RA; Edwards, MS; Powers, SK | 1 |
| Nakagawa, K; Tsunemoto, H; Watanabe, I | 1 |
| Gi, H; Handa, H; Oda, Y; Ono, K; Otsuka, S; Suda, K; Takeuchi, J; Yamashita, J | 1 |
| Brody, H; Chao, CF; Johnson, RJ; Shen, J; Subjeck, JR | 1 |
| Clarke, C; Dawson, KB; Sheldon, PW | 2 |
| Johnston, A; Matheson, I; Plowman, PN | 1 |
| Dembs, NL; Mulcahy, RT; Ublacker, GA | 1 |
| Grdina, DJ; Milas, L; Thames, HD | 1 |
| Casanovas, AM; Labat, C; Malmary, MF; Oustrin, J | 1 |
| Bump, EA; Koch, CJ; Stobbe, CC | 1 |
| Hendry, JH; Sutton, ML | 1 |
| Asakawa, H; Hoshino, T; Watarai, J | 1 |
| Siemann, DW; Wallen, CA; Wheeler, KT; Wolf, KL | 1 |
| Morrissey, S; Siemann, DW; Wheeler, KT; Wolf, K | 1 |
| Glatstein, E; Johnston, M; Kelly, B; Kinsella, TJ; Rowland, J; Schwade, JG | 1 |
| Ide, H; Kagiya, T; Nishimoto, S; Ono, S; Wada, T | 1 |
| Roberts, PB | 1 |
| Ammon, J; Bamberg, M; Calcanis, A; Godehardt, E; Herbst, M; Keim, H; Kleibel, F; Makoski, HB; Potthoff, PC; Sack, H; Schlegel, G; Schnepper, E; Weidtman, V; Zülch, KJ | 1 |
| Kylmämaa, TT; Mäntylä, MJ; Nordman, EM; Ruotsalainen, PJ | 1 |
| Abe, M; Hiraoka, M; Ono, K; Takahashi, M | 1 |
| Arcangeli, G; Mauro, F; Nervi, C | 1 |
| Curtis, S; Guichard, M; Malaise, EP; Tenforde, T | 1 |
| Lang, MA; McManus, ME; Strong, J; Stuart, K | 1 |
| Kleine, W; Ladner, HA; Nagy, D; Stange, S | 1 |
| Ang, KK; Chenal, C; Fauchon, F; Goffin, JC; Horiot, JC; Notter, G; Raps, J; van der Schueren, E; van Glabbeke, M; van Peperzeel, H; Vessière, M | 1 |
| Powers, EL | 1 |
| Chao, CF; Johnson, RJ; Subjeck, JR | 1 |
| Twentyman, PR; Workman, P | 2 |
| Sissingh, HA; van der Kogel, AJ | 1 |
| Jinks, S; Millar, BC | 2 |
| Edgren, M | 1 |
| Morrissey, S; Siemann, DW; Wolf, K | 1 |
| Brown, JM; Bump, EA; Taylor, YC | 1 |
| Begg, E; O'Shea, K; Wade, D; Williams, K | 1 |
| Baer, K; Chapman, JD; Lee, J | 1 |
| Collis, CH; Down, JD; Jeffery, PK; Steel, GG | 1 |
| Cordt-Riehle, I; Fritz-Niggli, H; Michel, C; Schäppi, K | 1 |
| Bonnat, C; Colin, JN; Diquet, B; Singlas, E | 1 |
| Varghese, AJ | 2 |
| Collins, JM; Gianni, L; Greene, RF; Jenkins, JF; Lichter, AS; Myers, CE | 1 |
| Begg, EJ; O'Shea, K; Wade, DN; Williams, KM | 1 |
| Brown, DM; Brown, JM; Cohen, MS; Gonzalez-Mendez, R; Hahn, GM; Sagerman, RH | 1 |
| Brown, JM; Evans, JW; Taylor, YC | 1 |
| Abratt, RP; Barnes, DR; Cridland, JS; Green, JA; Johnson, MB; Sealy, R; Tucker, RD; Williams, MA | 1 |
| Brown, DM; Brown, JM; Gonzalez-Mendez, R | 1 |
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| Born, JL; Garcia, DJ; Smith, BR | 1 |
| Begg, EJ; O'Shea, KF; Wade, DN; Williams, KM | 1 |
| Dembs, N; Mulcahy, RT | 1 |
| Blasberg, R; Fenstermacher, J; Horowitz, M; Kornblith, P; Molnar, P; Pleasants, R; Strong, J | 1 |
| Goldman, P; Koch, RL; Sudlow, G; Yeung, TC | 1 |
| Carter, SK; Coleman, CN; Friedman, MK; Gribble, M; Halsey, J; Hirst, VK; Ignoffo, R; Jacobs, C; Leibel, S; Phillips, TL | 1 |
| Brailovsky, CA; Elhilali, MM; Fathi, MA; Fisher, GJ; Nigam, VN; Pageau, R; Tahan, TW | 1 |
| Josephy, PD; Palcic, B; Skarsgard, LD | 2 |
| Gangji, D; Poplack, DG; Schwade, J; Strong, JM; Wood, JH | 1 |
| White, RA; Workman, P | 2 |
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| Harrison, IE; Palcic, B; Skarsgard, LD; Skov, KA | 1 |
| Crabtree, KE; Curtis, SB; Flynn, MJ; Howard, J; Lyman, JT; Parr, SS; Tenforde, SD; Tenforde, TS | 1 |
| Adams, GE; Fielden, EM; Hardy, C; Millar, BC; Stratford, IJ; Williamson, C | 1 |
| Afzal, SM; Curtis, SB; Howard, J; Lyman, JT; Parr, SS; Tenforde, TS | 1 |
| Haveman, J; van der Schueren, E; Wondergem, J | 1 |
| Cramp, WA; Cresswell, S; George, AM; Lunec, J; Sun, GQ | 1 |
| Kacinski, BM; Mroczkowski, Z; Rupp, WD | 1 |
| Bamberg, M; Scherer, E; Streffer, C; Tamulevicius, P | 2 |
| Bleehen, NM; Gleave, JR; Hawkins, TD; Holmes, AE; Lewin, WS; Plowman, PN; Treip, CS; Watson, JV; Wiltshire, CR | 1 |
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| Arnold, EP; Bailey, C; Burry, AF; Bydder, PV; Firth, LA; Gowland, S; Gray, AJ; Mcllroy, R | 1 |
| Phillips, TL; Stetz, J; Wasserman, TH | 2 |
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| Kapp, DS; Rockwell, S | 1 |
| Kiefer, J | 1 |
| Denekamp, J; Michael, BD; Minchinton, AI; Smithen, CE; Stewart, FA; Stratford, MR; Terry, NH | 1 |
| Bugden, RD; Gibson, P; Langler, AJ | 1 |
| Ho, KC; Kun, LE; Moulder, JE | 1 |
| Astor, M; Biaglow, JE; Hall, EJ; Parham, JC | 1 |
| Goldman, P; Koch, RL; Rich, TA; Rose, C | 1 |
| Twentyman, P; Workman, P | 1 |
| Down, JD; Holmes, SJ; Parkins, CS; Travis, EL | 1 |
| Clutterbuck, RD; McElwain, TJ; Millar, JL | 1 |
| Chapman, JD; Franko, AJ | 1 |
| Brown, JM; Hirst, DG | 1 |
| Hoerauf, R; McManus, ME; Shoemaker, DD; Strong, JM | 1 |
| Phillips, TL; VanRaalte, G; Wasserman, TH | 1 |
| Carella, RJ; Concannon, JP; Perez, CA; Phillips, TL; Simpson, JR | 1 |
| Denekamp, J; Randhawa, VS; Stewart, FA | 1 |
| Rauth, AM; Taylor, YC | 2 |
| Creasey, WA; Thrall, DE | 1 |
| Adams, GE; Smith, E; Stratford, IJ | 1 |
| Horsman, MR; Stratford, IJ | 1 |
| Hansen, HS; Kamieniecka, Z; Melgaard, B; Paulson, OB; Pedersen, AG; Tang, X; Trojaborg, W | 1 |
| Erickson, LC; McManus, ME; Ramonas, LM | 1 |
| Freauff, S; Krohn, KA; Rasey, JS | 1 |
| Biaglow, JE; Varnes, ME | 1 |
| Breur, K; Haveman, J; van den Hoeven, H; van der Schueren, E; Wondergem, J | 2 |
| Nielsen, OS; Overgaard, J; Overgaard, M; Pedersen, AK; Timothy, AR | 1 |
| Abratt, RP | 1 |
| Arcangeli, G; Chaplain, G; Gonzalez, D; Horiot, JC; Svoboda, V; Van den Bogaert, W; van der Schueren, E | 1 |
| Beierle, FA; Hubbard, RW | 1 |
| Langer, M; Röttinger, EM; Weidenmaier, W | 1 |
| Otsuka, S | 1 |
| Ash, D; Bugden, R; Calvert, R | 1 |
| Glatte, P; Haedecke, U; Osieka, R; Schmidt, CG | 1 |
| Forgione, H; Kramer, S; Mohiuddin, M; Phillips, T; Soberon, M | 1 |
| Adams, GE; Stratford, IJ; Williamson, C | 1 |
| Edwards, DI; Knight, RC; Rowley, DA; Skolimowski, IM | 1 |
| Adams, GE; Horsman, MR; Kandaiya, S; Rajaratnam, S; Smith, E; Stratford, IJ; Williamson, C | 1 |
| Fritz-Niggli, H; Michel, C | 1 |
| Aritake, S; Sakamoto, K | 1 |
| Brown, DM; Brown, JM; Parker, E | 1 |
| Adomat, H; Josephy, PD; Palcic, B; Rootman, J | 1 |
| Clarke, C; Hobbiger, F; Sheldon, PW | 1 |
| Gerd, CR; Miller, RC; Schwartz, LE | 1 |
| Conroy, PJ; Maurissen, JP; Passalacqua, W; Sutherland, RM; Von Burg, R; Weiss, B | 1 |
| Gangji, D; Schwade, JG; Strong, JM | 2 |
| Gangji, D; Schwade, JG; Shoemaker, DD; Strong, JM; Upton, DK | 1 |
| Dawes, PJ; Henk, JM; Moore, JL; Paterson, IC | 1 |
| Dische, S; Minchinton, A; Rich, TA; Saunders, MI; Stratford, MR | 1 |
| Rebert, CS | 1 |
| Bennett, MH; Dische, S; Hauck, J; Minchinton, AI; Riley, PJ; Saunders, MI; Stratford, MR | 1 |
| Mahood, JS; Willson, RL | 1 |
| Whillans, DW; Whitmore, GF | 1 |
| Chin, JB; Rauth, AM | 1 |
| Kochanski, K; Siemann, DW | 1 |
| Courtenay, VD; Mills, J; Peacock, JH; Rose, CM; Spooner, D; Stephens, TC | 1 |
| De Ronde, J; Martin, WM; McNally, NJ | 1 |
| Field, SB; Morris, CC | 1 |
| Hampel, N; Persky, L | 1 |
| Barratt, GM; Wills, ED | 1 |
| Bruno, LA; Carabell, SC; Chang, CH; Goodman, RL; Richter, MP; Weiler, CB; Weinstein, AS | 1 |
| Howell, RL; Koch, CJ | 1 |
| Maimonis, P; Michaels, HB; Sedlacek, R; Suit, HD | 1 |
| Brown, JM; Hirst, DG; Law, MP | 1 |
| Brown, JM; Workman, P | 1 |
| de Rey, BM; Itoiz, ME; Klein-Szanto, AJ; Lanfranchi, HE | 1 |
| Budzicka, E; Niepokojczycka, E; Szumiel, I | 1 |
| Niepokojczycka, E; Szumiel, I; Walicka, M | 1 |
| Moore, JL; Newman, H; Paterson, IC; Venables, S | 1 |
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| Collins, JM; McManus, ME; Monks, A; Strong, JM; White, R | 1 |
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| Fielden, EM; Jenkins, TC; Millar, BC | 1 |
| Grimmett, EV; Hofer, KG; Lehr, JE; MacKinnon, AR; Schubert, AL | 1 |
| Astor, M; Biaglow, JE; Hall, EJ; Varnes, ME | 1 |
| Jinks, S; Millar, BC; Powles, TJ | 1 |
| Bleehen, NM; Morgan, JE | 1 |
| Maezawa, H; Mori, T; Ohizumi, Y; Shibata, C; Ushiro, S | 1 |
| Fazekas, JT; Goodman, RL; McLean, CJ | 1 |
| Abe, M; Furunishi, H; Kawanishi, K; Suyama, S; Yabumoto, E; Yamazaki, T | 1 |
| Conroy, PJ; Passalacqua, W; Sutherland, RM; von Burg, R | 1 |
| Denekamp, J; Hirst, DG; Stewart, FA; Terry, NH | 1 |
| Bleehen, NM; Wiltshire, CR; Workman, P | 1 |
| Priseman, SJ; Prosser, JS | 1 |
| Hesketh, LC; Prosser, JS | 1 |
| Stewart, F | 1 |
| Arcangeli, G; Barocas, A; Mauro, F; Nervi, C; Spanò, M; Tabocchini, A | 1 |
| Bleehen, NM; Honess, DJ; Morgan, JE; Workman, P | 1 |
| Adams, GE; Biaglow, JE; Fielden, EM; Jacobson, B | 1 |
| Conroy, PJ; Passalacqua, W; Sutherland, RM | 1 |
| Gueulette, J; Guichard, M; Malaise, EP; Octave-Prignot, M; Wambersie, A | 1 |
| Courdi, A; Malaise, EP | 1 |
| Mori, T; Ohizumi, Y; Shibata, C | 1 |
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| Anderson, P; Dische, S; Fowler, JF; Lee, ME; Minchinton, AI; Saunders, MI; Stratford, MR | 1 |
| Denekamp, J; Fowler, JF; Joiner, MC; McNally, NJ | 1 |
| Denekamp, J | 1 |
| Grdina, DJ; Jovonovich, JA; Sigdestad, CP | 1 |
| Geard, CR; Rutledge-Freeman, MH | 1 |
| Notter, G; Rylander, U; Turesson, I | 1 |
| Abt, AB; Albert, A; Stryker, JA | 1 |
| Kogelnik, HD; Mamoli, B; Reinartz, G; Seitz, W; Stark, H; Szepesi, T; Wessely, P; Wurst, F | 1 |
| Abratt, RP; Blackburn, JD | 1 |
| Begg, AC; Brown, JM; Fu, KK; Hurst, S | 1 |
| Abd El Moneim, H; Akoush, H; Awwad, HK; Burgers, MV; El Badawy, S; El Merzabani, MM; Ezzat, S; Khafagy, M; Saiid, A; Soliman, O | 1 |
| Tannock, IF | 2 |
| Allalunis, MJ; Meeker, BE; Pedersen, JE; Turner, AR; Urtasun, RC | 1 |
| Cooper, JS; Waltzman, SB | 1 |
| Catane, R; Clement, JJ; Gorman, MS; Johnson, RK; Wodinsky, I | 1 |
| Cherif, A; Gretzer, MB; Kim, EE; Li, C; Podoloff, DA; Wallace, S; Yang, DJ | 1 |
| Tada, T | 1 |
| Streffer, C; Tamulevicius, P | 1 |
| Abe, M; Iwai, H; Matsuno, E; Sasai, K; Shibamoto, Y | 1 |
| Hori, H; Inayama, S; Mori, T; Murayama, C; Nagasawa, H; Nakajima, T; Onoyama, Y; Tada, T | 1 |
| Adams, GE; Bradley, JK; Bremner, JC; Naylor, MA; Sansom, JM; Stratford, IJ | 1 |
| Chapman, JD; Jaiswal, AK; Joseph, P; Stobbe, CC | 1 |
| Giandomenico, AR; Iyengar, CW; Koch, CJ | 1 |
| Adams, GE; Fielden, EM; Naylor, MA; Showalter, HD; Stephens, MA; Stratford, IJ; Threadgill, MD | 1 |
| Bremner, JC | 1 |
| Cowan, DS; Hicks, KO; Wilson, WR | 1 |
| Cherif, A; Harrod, VL; Inoue, T; Kim, CG; Kim, EE; Kuang, LR; Newman, RA; Nornoo, A; Podoloff, DA; Wallace, S; Yang, DJ | 1 |
| Stypinski, D; Wiebe, LI | 1 |
| Cherif, A; Hunter, N; Inoue, T; Kim, EE; Milas, L; Milross, CG; Podoloff, DA; Tansey, W; Wallace, S; Yang, DJ | 1 |
| Akuta, K; Kinashi, Y; Masunaga, S; Ono, K; Suzuki, M | 1 |
| Adams, GE; Horsman, MR; Khalil, AA; Overgaard, J; Steinberg, F; Stratford, IJ; Streffer, C; Wood, PJ | 1 |
| Battino, M; Breccia, A; Ferri, E; Gattavecchia, E; Genova, ML; Lenaz, G; Littarru, GP | 1 |
| Bauer, AA; Belnavis, L; Chan, YW; Di Rocco, RJ; Kuczynski, BL; Linder, KE; Narra, RK; Nowotnik, DP; Nunn, AD; Pirro, JP | 1 |
| Griffin, TW; Hamlin, DK; Laramore, GE; Livesey, JC; Srivastava, RR; Wilbur, DS | 1 |
| Melo, T; Misra, V; Rauth, AM | 1 |
| Sinusas, AJ | 1 |
| Adams, GE; Asquith, JC; Patel, K; Smithen, CE; Watts, ME | 1 |
| Denekamp, J; Harris, SR; Michael, BD | 1 |
| Ando, K; Aoki, M; Furusawa, Y; Kuwabara, Y; Maeda, M; Masuda, K; Sasaki, S; Yamamoto, F | 1 |
| Airley, R; Cowen, RL; Honess, D; Jaffar, M; Patterson, AV; Saunders, M; Stratford, IJ; Telfer, BA; van der Kogel, AJ; Williams, KJ; Wolf, CR | 1 |
| Banáth, JP; Durand, RE; Olive, PL | 1 |
| Buchko, GW; Weinfeld, M | 1 |
| Bergman, J; Eskola, O; Kulmala, J; Lehtiö, K; Minn, H; Oikonen, V; Tolvanen, T | 1 |
| Cai, S; Chapman, JD; Chen, Y; Finn, R; Gerweck, L; Humm, J; Larson, S; Ling, C; O'Donoghue, J; Ruan, S; Schneider, R; Wen, B; Zanzonico, P | 1 |
| Bentzen, L; Eskola, O; Grönroos, T; Haaparanta, M; Horsman, MR; Keiding, S; Marjamäki, P; Minn, H; Murata, R; Solin, O | 1 |
| Bormans, G; Dubois, L; Dupont, P; Flamen, P; Haustermans, K; Landuyt, W; Mortelmans, L; Verbeken, E; Vermaelen, P | 1 |
| Beck, R; Kumar, P; Machulla, HJ; McEwan, AJ; Picchio, M; Piert, M; Reischl, G; Schwaiger, M; Wester, HJ; Wiebe, LI; Ziegler, S | 1 |
| Burgman, P; Burnazi, E; Cai, S; Finn, RD; Humm, JL; Lewis, JS; Ling, CC; O'Donoghue, JA; Pugachev, A; Ruan, S; Smith-Jones, P; Welch, MJ; Wen, B; Zanzonico, P | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, M; Troost, EG; van der Kogel, AJ | 1 |
| Alber, M; Eschmann, SM; Holzner, F; Paulsen, F; Thorwarth, D | 1 |
| Brader, P; Fong, Y; Hricak, H; Humm, JL; Ling, CC; Reid, V; Riedl, CC; Wen, B; Woo, Y; Zanzonico, P | 1 |
| Boerman, OC; Bussink, J; Kaanders, JH; Laverman, P; Lok, J; Oyen, WJ; Philippens, ME; Troost, EG; van der Kogel, AJ | 1 |
| Cheguillaume, A; De Bast, M; de Groot, T; Gillart, J; Grégoire, V; Haustermans, K; Labar, D; Mahy, P | 1 |
| Bol, A; Bormans, G; Cloetens, L; Dubois, L; Grégoire, V; Haustermans, K; Labar, D; Landuyt, W; Mortelmans, L; Nuyts, J | 1 |
| Chen, Q; Deng, X; He, F; Huang, Y; Li, GC; Ling, CC; Liu, Y; Minami, A; Sun, X; Wen, B; Xing, L; Zanzonico, PB | 1 |
| Ackerstaff, E; Carlin, S; Cho, H; Humm, JL; Koutcher, JA; Ling, CC; Lupu, ME; O'Donoghue, J; Rizwan, A; Wang, Y; Zanzonico, PB | 1 |
| Chitneni, SK; Dewhirst, MW; Palmer, GM; Zalutsky, MR | 1 |
| Cheeseman, C; Khlebnikov, V; Kumar, P; Liang, H; Shustov, G; Wiebe, LI; Yang, XH; Zheng, W | 1 |
| Civelek, AC; Huang, T; Jiang, H; Li, J; Li, XF; Ng, CK; Postel, GC; Shen, B | 1 |
| Chen, L; Guan, Y; Kolb, HC; Walsh, JC; Zhang, J; Zhang, Z | 1 |
| Dierckx, RA; Halmos, GB; Langedijk, JA; Pruim, J; Roodenburg, JL; van der Laan, BF; Wedman, J | 1 |
| Hanzawa, H; Hatano, T; Kuge, Y; Kuno, N; Nishijima, K; Sakamoto, T; Tamaki, N; Zhao, S; Zhao, Y | 1 |
| Elliott, W; Leopold, J; Leopold, W; Sercel, A; Showalter, H; Suto, C; Winters, T | 1 |
| Giraud, P; Servagi-Vernat, S | 1 |
| Dubois, L; Eriksson, J; Lambin, P; Lieuwes, NG; Peeters, SG; van Dongen, GA; van Elmpt, W; Zegers, CM | 1 |
| Galoforo, S; Grills, IS; Kane, JL; Krueger, SA; Marples, B; Wilson, GD; Wobb, J | 1 |
| Mönnich, D; Thorwarth, D; Troost, EG; van Elmpt, W; Wack, LJ; Zegers, CM; Zips, D | 1 |
| Yoshimoto, M | 1 |
| Hu, X; Huang, Y; Wang, S; Wei, Y; Yu, J; Yu, Q; Yuan, S; Zhao, S; Zhao, W; Zhu, S | 1 |
| Baumann, M; Mönnich, D; Thorwarth, D; Wack, LJ; Yaromina, A; Zips, D | 1 |
| Barnes, SL; Kang, H; Quarles, CC; Sanchez, V; Sorace, AG; Syed, AK; Yankeelov, TE | 1 |
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| Cheon, GJ; Kang, SY; Lee, KH; Oh, DY; Yoon, J | 1 |
| Fuentes, A; Healey, DR; Kodibagkar, VD; Quarles, CC; Scarpelli, ML | 1 |
| Angermeier, A; Della Manna, D; Larimer, BM; Li, Y; Reeves, KM; Song, PN; Sorace, AG; Wang, J; Yang, ES | 1 |
24 review(s) available for azomycin and misonidazole
| Article | Year |
|---|---|
Pharmacokinetics and subcellular localization of radiosensitizers.
Topics: Etanidazole; Humans; Hydrogen-Ion Concentration; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Bioreductive drugs in cancer therapy.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cell Hypoxia; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
[Radiosensitizer: hypoxic cell radiosensitizer].
Topics: Animals; DNA; Dogs; Etanidazole; Hydroxamic Acids; Hydroxylation; Intercalating Agents; Lethal Dose 50; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Thymine | 1989 |
[Present status of radiation sensitizers--hypoxic cell radiosensitizer].
Topics: Animals; Hydroxamic Acids; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Hypoxia-mediated nitro-heterocyclic drugs in the radio- and chemotherapy of cancer. An overview.
Topics: Alkylating Agents; Animals; Cell Survival; Drug Synergism; Etanidazole; Hypoxia; Misonidazole; Neoplasms, Experimental; Nitrofurans; Nitrofurazone; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1986 |
Biochemistry of reduction of nitro heterocycles.
Topics: Animals; Buthionine Sulfoximine; Catalase; Cell Division; Cell Survival; Etanidazole; Free Radicals; Glucose; Glutathione; Glycolysis; Hexosephosphates; Humans; Hypoxia; Methionine Sulfoximine; Microbodies; Microsomes; Misonidazole; Mitochondria; Nitroimidazoles; Oxidation-Reduction; Pentoses; Peroxidases; Sulfhydryl Compounds | 1986 |
Sensitizers and radiation dose fractionation: results and interpretations.
Topics: Animals; Combined Modality Therapy; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1986 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Sensitizers and protectors in clinical oncology.
Topics: Alkylating Agents; Amifostine; Animals; Drug Synergism; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1981 |
Modification of chemotherapy by nitroimidazoles.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
[Cancer and radiotherapy. (4). Hypoxic cell sensitizers and hyperthermia combined with radiation in cancer treatment].
Topics: Acetophenones; Animals; Hot Temperature; Humans; Mice; Misonidazole; Neoplasms; Nitrofurans; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1982 |
Radiation sensitization studies in Japan.
Topics: Animals; Cell Survival; Drug Evaluation; Half-Life; Humans; Japan; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1981 |
Assessing the bioreductive effectiveness of the nitroimidazole RSU1069 and its prodrug RB6145: with particular reference to in vivo methods of evaluation.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Cell Survival; Humans; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents | 1993 |
Pharmacokinetics of SPECT radiopharmaceuticals for imaging hypoxic tissues.
Topics: Animals; Cell Hypoxia; Humans; Iodine Radioisotopes; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Radiopharmaceuticals; Technetium; Tomography, Emission-Computed, Single-Photon | 1996 |
The potential for myocardial imaging with hypoxia markers.
Topics: Animals; Cell Hypoxia; Heart; Humans; Misonidazole; Myocardial Stunning; Nitroimidazoles; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals | 1999 |
Molecular imaging of hypoxia.
Topics: Humans; Hypoxia; Misonidazole; Neoplasms; Neovascularization, Pathologic; Nitroimidazoles; Positron-Emission Tomography; Radiography; Radiopharmaceuticals | 2011 |
Alternative PET tracers in head and neck cancer. A review.
Topics: Amino Acids; Antibodies, Monoclonal; Carbon Radioisotopes; Carcinoma, Squamous Cell; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Misonidazole; Nitroimidazoles; Nucleosides; Positron-Emission Tomography; Radiopharmaceuticals | 2013 |
[Metabolic tailoring in radiotherapy for head and neck cancer].
Topics: Carcinoma, Squamous Cell; Cell Hypoxia; Clinical Trials as Topic; Diffusion Magnetic Resonance Imaging; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Misonidazole; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Image-Guided; Tumor Burden | 2014 |
[Current Status and Prospects on PET Radiopharmaceuticals for Radiotherapy].
Topics: Animals; Boron Compounds; Boron Neutron Capture Therapy; Coordination Complexes; Fluorine Radioisotopes; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Phenylalanine; Positron-Emission Tomography; Radiopharmaceuticals; Thiosemicarbazones | 2015 |
[Accumulation Mechanism of 2-Nitroimidazole-based Hypoxia Imaging Probes Revealed by Imaging Mass Spectrometry].
Topics: Animals; Glutathione; Glutathione Transferase; Humans; Hypoxia; Mass Spectrometry; Mice; Misonidazole; Molecular Imaging; Molecular Probes; Multidrug Resistance-Associated Proteins; Neoplasms; Nitroimidazoles; Positron-Emission Tomography | 2018 |
51 trial(s) available for azomycin and misonidazole
| Article | Year |
|---|---|
Initial United States clinical and pharmacologic evaluation of misonidazole (Ro-07-0582), an hypoxic cell radiosensitizer.
Topics: Administration, Oral; Drug Administration Schedule; Drug Evaluation; Humans; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Sensation; Vomiting | 1979 |
Misonidazole-a drug for trial in radiotherapy and oncology.
Topics: Anorexia; Clinical Trials as Topic; Drug Eruptions; Female; Humans; Male; Misonidazole; Nausea; Neoplasms; Nitroimidazoles; Peripheral Nervous System Diseases; Seizures | 1979 |
[Clinical testing of the radiosensitizer RO-07-0582 (misonidazole). Dose tolerance, toxicity and pharmacokinetic studies, preliminary report (author's transl)].
Topics: Bone Neoplasms; Clinical Trials as Topic; Glioma; Humans; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles; Otorhinolaryngologic Diseases; Sarcoma | 1978 |
Sensitizers and protectors in radiotherapy.
Topics: Amifostine; Animals; Aziridines; Clinical Trials as Topic; Drug Evaluation; Etanidazole; Glutathione; Humans; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy | 1985 |
Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter trial of
Topics: Actuarial Analysis; Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Scandinavian and Nordic Countries; Telencephalon | 1985 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Etanidazole; Humans; Metronidazole; Misonidazole; Neoplasms; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Multiple daily fractionated radiation therapy and misonidazole in the management of malignant astrocytoma. A preliminary report.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Random Allocation; Time Factors | 1985 |
Misonidazole combined with hyperfractionation in the management of malignant glioma.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Glioblastoma; Glioma; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radiotherapy Dosage; Random Allocation | 1984 |
Misonidazole and irradiation in the treatment of high-grade astrocytomas: further report of the Vienna Study Group.
Topics: Brain Neoplasms; Clinical Trials as Topic; Female; Glioblastoma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Random Allocation | 1984 |
Misonidazole neuropathy.
Topics: Aged; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Pharyngeal Neoplasms | 1984 |
Experience in the radical radiotherapy of cancer in the bilharzial bladder: the use of misonidazole.
Topics: Aged; Female; Follow-Up Studies; Humans; Kidney; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Radiotherapy; Schistosomiasis; Urinary Bladder Diseases; Urinary Bladder Neoplasms | 1984 |
Clinical trials with hypoxic cell sensitizers: time to retrench or time to push forward?
Topics: Clinical Trials as Topic; Combined Modality Therapy; Dexamethasone; Drug Evaluation; Etanidazole; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Dose-response relationships for human tumors: implications for clinical trials of dose modifying agents.
Topics: Animals; Clinical Trials as Topic; Dose-Response Relationship, Radiation; Etanidazole; Humans; Mice; Misonidazole; Neoplasms; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Neuropathy of nitroimidazole radiosensitizers: clinical and pathological description.
Topics: Etanidazole; Humans; Misonidazole; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents; Sural Nerve | 1984 |
Clinical experience with misonidazole: high dose fractions versus daily low doses.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Eruptions; Epilepsy; Female; Hearing Loss; Humans; Male; Middle Aged; Misonidazole; Neurocognitive Disorders; Nitroimidazoles; Peripheral Nervous System Diseases | 1980 |
A phase I study of misonidazole and pelvic irradiation in patients with carcinoma of cervix.
Topics: Double-Blind Method; Drug Evaluation; Female; Hearing Loss; Humans; Kinetics; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Random Allocation; Thrombocytopenia; Uterine Cervical Neoplasms | 1982 |
Radiation and nitroimidazoles in supratentorial high grade gliomas: a second clinical trial.
Topics: Adult; Aged; Cerebellar Neoplasms; Clinical Trials as Topic; Glioblastoma; Humans; Metronidazole; Middle Aged; Misonidazole; Nitroimidazoles; Random Allocation | 1982 |
Dose-response curves for predicting misonidazole-induced peripheral neuropathy.
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Esophageal Neoplasms; Half-Life; Humans; Injections, Intravenous; Kinetics; Metabolic Clearance Rate; Misonidazole; Nitroimidazoles; Osteosarcoma; Peripheral Nervous System Diseases; Probability | 1982 |
Misonidazole combined with radiotherapy in the treatment of inoperable squamous cell carcinoma of the lung. A double-blind randomized trial.
Topics: Aged; Carcinoma, Squamous Cell; Double-Blind Method; Esophagitis; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Placebos; Pneumonia; Radiation Injuries; Radiotherapy Dosage; Random Allocation; Vomiting | 1983 |
A study of the effect of misonidazole in conjunction with radiotherapy for the treatment of grades 3 and 4 astrocytomas. A report from the MRC Working Party on misonidazole in gliomas.
Topics: Adolescent; Adult; Aged; Cerebellar Neoplasms; Clinical Trials as Topic; Double-Blind Method; Glioblastoma; Humans; Kinetics; Middle Aged; Misonidazole; Nitroimidazoles; Patient Compliance; Random Allocation | 1983 |
A study of the effect of misonidazole in conjunction with radiotherapy for the treatment of head and neck cancer. MRC working party on misonidazole in head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Radiotherapy; Radiotherapy Dosage; Random Allocation | 1984 |
Misonidazole in radiotherapy of supratentorial malignant brain gliomas in adult patients: a randomized double-blind study.
Topics: Adult; Brain Neoplasms; Clinical Trials as Topic; Double-Blind Method; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Prognosis; Radiotherapy Dosage; Time Factors | 1983 |
A randomized comparison of misonidazole sensitized radiotherapy plus BCNU and radiotherapy plus BCNU for treatment of malignant glioma after surgery; preliminary results of an RTOG study.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Carmustine; Clinical Trials as Topic; Drug Administration Schedule; Glioma; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Random Allocation | 1983 |
[Clinical trials of hypoxic cell sensitizer misonidazole].
Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Random Allocation; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1983 |
Clinical trials with hypoxic cell sensitizers-the European experience.
Topics: Animals; Brain Neoplasms; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Methods; Misonidazole; Neoplasms; Nitroimidazoles; Urinary Bladder Neoplasms | 1983 |
Treatment of bladder carcinoma with irradiation combined with misonidazole.
Topics: Aged; Clinical Trials as Topic; Cobalt Radioisotopes; Combined Modality Therapy; Female; Humans; Male; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage; Urinary Bladder Neoplasms | 1983 |
The Medical Research Council trial of misonidazole in carcinoma of the uterine cervix. A report from the MRC Working Party on misonidazole for cancer of the cervix.
Topics: Adult; Aged; Brachytherapy; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Prognosis; Radiation Injuries; Radiotherapy Dosage; Uterine Cervical Neoplasms | 1984 |
Primary tumor control after radiotherapy for carcinoma of the bronchus.
Topics: Bronchial Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Clinical Trials as Topic; Double-Blind Method; Humans; Misonidazole; Neoplasm Metastasis; Nitroimidazoles; Radiation Tolerance | 1984 |
Radical irradiation and misonidazole for T2 grade III and T3 bladder cancer: 2 year follow-up.
Topics: Adult; Aged; Clinical Trials as Topic; Follow-Up Studies; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 1984 |
The treatment of locally advanced head and neck cancer with misonidazole, hyperbaric oxygen and irradiation: an interim report.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Combined Modality Therapy; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Middle Aged; Misonidazole; Nitroimidazoles; Pilot Projects; Prospective Studies; Radiation-Sensitizing Agents; Random Allocation | 1984 |
Is misonidazole neurotoxicity altered by the use of phenytoin and/or dexamethasone in RTOG 79-18 and RTOG 79-16?
Topics: Brain Neoplasms; Clinical Trials as Topic; Dexamethasone; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nervous System Diseases; Nitroimidazoles; Phenytoin; Radiation-Sensitizing Agents | 1984 |
Hyperfractionated radiotherapy with or without misonidazole: results of a prospective randomized study in stage III-IV squamous cell carcinoma of the head and neck.
Topics: Aged; Carcinoma, Squamous Cell; Clinical Trials as Topic; Cobalt Radioisotopes; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Prospective Studies; Radiation-Sensitizing Agents; Radioisotope Teletherapy; Radiotherapy Dosage; Random Allocation | 1984 |
[Clinical evaluation of misonidazole combined with radiotherapy in the treatment of carcinoma of the esophagus--a double-blind randomized trial].
Topics: Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Esophageal Neoplasms; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Random Allocation | 1984 |
Hypoxic cell radiosensitizers--present and future.
Topics: Animals; Central Nervous System; Clinical Trials as Topic; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1981 |
Detection of a reactive metabolite of misonidazole in human urine.
Topics: Combined Modality Therapy; Female; Humans; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 1984 |
Misonidazole with dexamethasone rescue: an escalating dose toxicity study.
Topics: Adolescent; Adult; Aged; Dexamethasone; Dose-Response Relationship, Drug; Humans; Middle Aged; Misonidazole; Neoplasms; Nervous System Diseases; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
[Biological and physical approach to the improvement of radiotherapy].
Topics: Animals; Cell Survival; Hot Temperature; Humans; Lung Neoplasms; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiotherapy | 1983 |
[Clinical evaluation of hypoxic cell sensitizer (Misonidazole)].
Topics: Aged; Esophageal Neoplasms; Female; Humans; Kidney; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Oxygen; Stomach Neoplasms; Tongue Neoplasms; Uterine Cervical Neoplasms | 1984 |
Clinical experience with intravenous misonidazole for carcinoma of the esophagus: results in attempting radiosensitization of each fraction of exposure.
Topics: Combined Modality Therapy; Esophageal Neoplasms; Humans; Injections, Intravenous; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
[Postoperative radiotherapy of astrocytomas grade 3 and 4 with the radiosensitizer misonidazole. -End results of a multicentric controlled German study].
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Germany, West; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Postoperative Care; Radiotherapy Dosage | 1982 |
Misonidazole and radiotherapy in lung cancer: a randomized double-blind trial.
Topics: Aged; Carcinoma, Bronchogenic; Clinical Trials as Topic; Double-Blind Method; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Random Allocation | 1982 |
Radical irradiation and misonidazole in the treatment of T2 grade III and T3 bladder cancer.
Topics: Administration, Oral; Aged; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Pilot Projects; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 1983 |
Misonidazole in the clinic at Mount Vernon.
Topics: Adult; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Misonidazole; Nitroimidazoles | 1980 |
Misonidazole as a radiosensitizer in the radiotherapy of glioblastomas and oesophageal cancer. Pharmacokinetic and clinical studies.
Topics: Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Glioma; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles | 1981 |
A randomized study of misonidazole and radiotherapy for grade 3 and 4 cerebral astrocytoma.
Topics: Adolescent; Adult; Aged; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Random Allocation | 1981 |
A national trial on the treatment of invasive bladder cancer.
Topics: Carcinoma; Clinical Trials as Topic; Humans; Misonidazole; Nausea; Neoplasm Staging; New Zealand; Nitroimidazoles; Urinary Bladder Neoplasms; Vomiting | 1981 |
Radiation Therapy Oncology Group clinical trials with misonidazole.
Topics: Brain Neoplasms; Clinical Trials as Topic; Drug Administration Schedule; Glioma; Head and Neck Neoplasms; Humans; Misonidazole; Nausea; Nervous System Diseases; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Vomiting | 1981 |
MRC randomized studied of misonidazole in combination with radiotherapy.
Topics: Clinical Trials as Topic; Humans; Misonidazole; Neoplasms; Nitroimidazoles | 1982 |
Misonidazole in the preoperative and radical radiotherapy of bladder cancer.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Humans; Misonidazole; Nitroimidazoles; Preoperative Care; Prospective Studies; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 1980 |
A Comparative Study of Noninvasive Hypoxia Imaging with 18F-Fluoroerythronitroimidazole and 18F-Fluoromisonidazole PET/CT in Patients with Lung Cancer.
Topics: Adult; Aged; Demography; Female; Humans; Hypoxia; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron Emission Tomography Computed Tomography; Tissue Distribution | 2016 |
570 other study(ies) available for azomycin and misonidazole
| Article | Year |
|---|---|
Hypoxic-cell sensitisers.
Topics: Cell Survival; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen Consumption; Radiation Tolerance | 1978 |
Hypoxic-cell sensitisers.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
[Clinical experiences with the radiation-sensitizing agent misonidazole].
Topics: Brain Neoplasms; Cardiovascular System; Central Nervous System; Digestive System; Drug Eruptions; Eye; Female; Humans; Liver; Male; Misonidazole; Neoplasms; Nitroimidazoles | 1978 |
The neurotoxicity of misonidazole: pooling of data from five centres.
Topics: Dose-Response Relationship, Drug; Humans; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases | 1978 |
New side effect of the hypoxic cell sensitizer, misonidazole.
Topics: Aged; Brain Neoplasms; Drug Eruptions; Drug Therapy, Combination; Female; Glioblastoma; Humans; Male; Misonidazole; Nitroimidazoles | 1979 |
E.S.R. study of free radicals formed in the irradiated DNA-Ro 7-0582 complex.
Topics: DNA; Electron Spin Resonance Spectroscopy; Electrons; Free Radicals; Gamma Rays; Misonidazole; Nitroimidazoles; Nucleotides; Radiation Tolerance | 1979 |
Chemoradioprotection of the rat parotid gland by combined use of WR-2721 and Ro-07-0582.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Drug Combinations; Female; Misonidazole; Nitroimidazoles; Organ Size; Parotid Gland; Radiation-Protective Agents; Rats; Time Factors; X-Rays | 1979 |
Electroneurographic investigations of misonidazole polyneuropathy.
Topics: Action Potentials; Adult; Aged; Female; Humans; Male; Middle Aged; Misonidazole; Motor Neurons; Neoplasms; Nerve Fibers; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Peripheral Nervous System Diseases; Peroneal Nerve; Sural Nerve; Time Factors | 1979 |
The penetration of misonidazole into spontaneous canine tumours.
Topics: Adenocarcinoma; Anesthesia, Intravenous; Animals; Carcinoma, Squamous Cell; Disease Models, Animal; Dog Diseases; Dogs; Female; Fibrosarcoma; Half-Life; Lymphoma, Non-Hodgkin; Male; Mammary Glands, Animal; Meningioma; Misonidazole; Neoplasms; Nitroimidazoles; Osteosarcoma; Pentobarbital | 1979 |
Influence of the hypoxic cell sensitizer misonidazole on the proliferation of well-oxygenated cells in vitro during prolonged exposure.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Hypoxia; Mice; Misonidazole; Mitosis; Nitroimidazoles; Osteosarcoma; Oxygen; Sarcoma, Experimental; Time Factors | 1979 |
A metabolite of the 2-nitroimidazole misonidazole with radiosensitizing properties.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hypoxia; Lung; Mice; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Radiation Tolerance | 1978 |
Effect of misonidazole (Ro-07-0582) on the incidence of micronuclei in irradiated Ehrlich tumour ascites cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Nucleus; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred Strains; Misonidazole; Mutagens; Nitroimidazoles; Radiation-Sensitizing Agents; X-Rays | 1978 |
Structure-activity relationships in the development of hypoxic cell radiosensitizers. II. Cytotoxicity and therapeutic ratio.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Metronidazole; Misonidazole; Models, Biological; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Regression Analysis; Structure-Activity Relationship | 1979 |
Modification of radiation response in HeLa cells by misonidazole.
Topics: Cell Count; Cell Survival; Gamma Rays; HeLa Cells; Humans; Misonidazole; Mitosis; Nitroimidazoles; Oxygen; Time Factors; X-Rays | 1979 |
Evaluation of mutagenicity of metronidazole and mizonidazole on the base of lambda prophage induction and Ames test.
Topics: Animals; Escherichia coli; Metronidazole; Misonidazole; Mutagens; Nitroimidazoles; Rats; Salmonella typhimurium; Virus Activation | 1979 |
Relative efficacy of high-pressure oxygen and misonidazole to reduce TCD50 of a mouse mammary carcinoma.
Topics: Animals; Hyperbaric Oxygenation; Lethal Dose 50; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1979 |
Changes in nerve conduction velocity in the mouse after acute and chronic administration of nitroimidazoles.
Topics: Animals; Cell Survival; Electronics; Female; Metronidazole; Mice; Mice, Inbred CBA; Misonidazole; Neural Conduction; Nitroimidazoles; Sciatic Nerve; Solubility; Temperature | 1979 |
[New aspects of radiotherapy. I. Significance of hypoxia in irradiation of solid tumors].
Topics: Dose-Response Relationship, Radiation; Hot Temperature; Humans; Hyperbaric Oxygenation; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles | 1979 |
Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice.
Topics: Animals; Cell Survival; Guinea Pigs; Lung Neoplasms; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Tissue Distribution | 1979 |
Radiosensitizing effect of misonidazole in fractionated gamma-ray treatment of a human malignant melanoma grown in athymic nude mice.
Topics: Animals; Gamma Rays; Humans; Male; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiotherapy Dosage; Time Factors; Transplantation, Heterologous | 1979 |
Relationship between misonidazole toxicity and core temperature in C3H mice.
Topics: Animals; Body Temperature; Hot Temperature; Injections, Intraperitoneal; Lethal Dose 50; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1979 |
Peripheral electrophysiological parameters in mice treated with misonidazole.
Topics: Action Potentials; Animals; Body Temperature; Electrophysiology; Female; Median Nerve; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Misonidazole; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Sural Nerve; Tibial Nerve | 1979 |
Misonidazole enhancement of acute and late radiation injury to the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Paralysis; Radiation Injuries, Experimental; Rats; Rats, Inbred F344; Spinal Cord | 1979 |
Enhancement of radioresponse of a mouse mammary carcinoma to combined treatments with hyperthermia and radiosensitizer misonidazole.
Topics: Adenocarcinoma; Animals; Hot Temperature; Male; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Radiation Tolerance; Remission, Spontaneous; Time Factors; X-Rays | 1979 |
Influence of misonidazole on the radiosensitivity of a human melanoma in nude mice: time-dependent increase in surviving fraction.
Topics: Animals; Cell Survival; Female; Humans; Hypoxia; In Vitro Techniques; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1979 |
Pharmacokinetic considerations in testing hypoxic cell radiosensitizers in mouse tumours.
Topics: Animals; Female; Half-Life; Kidney; Ligation; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms, Experimental; Nephrectomy; Nitroimidazoles; Radiation-Sensitizing Agents | 1979 |
Evaluation of the anticholinesterase activity of metronidazole and misonidazole.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Electrophorus; Horses; In Vitro Techniques; Metronidazole; Misonidazole; Nitroimidazoles; Rats | 1979 |
Inhibition of DNA synthesis by nitroheterocycles. I. Correlation with half-wave reduction potential.
Topics: Animals; Depression, Chemical; DNA; Furylfuramide; L Cells; Metronidazole; Mice; Misonidazole; Nitrofurans; Nitroimidazoles; Nitroquinolines; Oxidation-Reduction; Thymidine | 1979 |
Release from the Crabtree effect by hypoxic cell radiosensitizers.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Glucose; Mice; Misonidazole; Nitro Compounds; Nitroimidazoles; Oxygen Consumption; Propiophenones; Radiation-Sensitizing Agents | 1979 |
Radiosensitization of mammalian cells by misonidazole and oxygen: DNA damage exposed by Micrococcus luteus enzymes.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Gamma Rays; Hypoxia; Micrococcus; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Ultraviolet Rays | 1979 |
Distribution of misonidazole in human tumours and normal tissues.
Topics: Brain Neoplasms; Breast Neoplasms; Female; Genital Neoplasms, Female; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Thyroid Diseases; Tissue Distribution; Urinary Bladder Neoplasms | 1979 |
Misonidazole and MTDQ in combination: cytotoxic and radiosensitizing properties in hypoxic mammalian cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Combinations; Misonidazole; Nitroimidazoles; Oxygen; Quinolines; Radiation-Sensitizing Agents | 1979 |
Effects of pretreatment with phenobarbitone and phenytoin on the pharmacokinetics and toxicity of phenytoin on the pharmacokinetics and toxicity of misonidazole in mice.
Topics: Animals; Body Temperature; Body Weight; Brain; Drug Interactions; Half-Life; Lethal Dose 50; Liver; Male; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Phenobarbital; Phenytoin; Sleep; Transplantation, Homologous | 1979 |
Cell-cycle inhibition by misonidazole of human cells cultivated in vitro under aerobic conditions.
Topics: Aerobiosis; Cell Cycle; Cell Line; Cell Survival; DNA; Humans; Interphase; Misonidazole; Mitosis; Nitroimidazoles | 1979 |
Biliary and faecal excretion of misonidazole in man.
Topics: Bile; Feces; Humans; Kinetics; Misonidazole; Nitroimidazoles | 1979 |
Misonidazole neurotoxicity in the mouse: evaluation of functional, pharmacokinetic, electrophysiologic and morphologic parameters.
Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Female; Kinetics; Male; Mice; Mice, Inbred Strains; Microscopy, Electron; Misonidazole; Neural Conduction; Nitroimidazoles; Peripheral Nerves | 1979 |
Cytotoxicity of misonidazole in vivo under conditions of prolonged contact of drug with the tumour cells.
Topics: Animals; Cell Survival; Half-Life; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms, Experimental; Nephrectomy; Nitroimidazoles; Time Factors | 1979 |
Care with radiosensitizers.
Topics: Animals; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1979 |
The pharmacokinetics of misonidazole in the dog.
Topics: Administration, Oral; Animals; Biological Availability; Dogs; Dose-Response Relationship, Drug; Half-Life; Injections, Intravenous; Kinetics; Male; Misonidazole; Nitroimidazoles | 1979 |
Radiosensitization of mouse L cells by an electron affinic radiosensitizer, Ro-07-0582 under an extremely hypoxic condition.
Topics: Aerobiosis; Anaerobiosis; Animals; Cell Survival; L Cells; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1979 |
The quantitative response of human tumours to radiation and misonidazole.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Radiation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Skin Neoplasms | 1979 |
A comparison of two nitroimidazoles and a dihydroquinoline as radiosensitizers and cytotoxic agents.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Hydroquinones; Misonidazole; Nitroimidazoles; Oxygen; Quinolines; Radiation-Sensitizing Agents | 1979 |
Split dose cytotoxic experiments with misonidazole.
Topics: Cell Survival; Cells, Cultured; Drug Administration Schedule; Misonidazole; Nitroimidazoles; Oxygen; Temperature; Time Factors | 1978 |
The toxicity of the radiosensitizer misonidazole towards hypoxic cells in vitro: a model for mouse and man.
Topics: Animals; Cell Survival; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Oxygen; Time Factors | 1978 |
The magnitude of hypoxic cell cytotoxicity of misonidazole in human tumours.
Topics: Cell Survival; Female; Humans; In Vitro Techniques; Misonidazole; Nitroimidazoles; Oxygen; Uterine Cervical Neoplasms | 1978 |
Oncogenic transformation in vitro by the hypoxic cell sensitizer misonidazole.
Topics: Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles | 1978 |
The effect of misonidazole on lymphocytes.
Topics: Chromosomes; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Misonidazole; Mitotic Index; Nitroimidazoles | 1978 |
Studies on the toxicity and radiosensitizing ability of misonidazole under conditions of prolonged incubation.
Topics: Cell Survival; Cells, Cultured; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Hypoxia; Misonidazole; Nitroimidazoles; Radiation Tolerance; Temperature; Time Factors | 1978 |
Influence of misonidazole on the incidence of radiation-induced intestinal tumours in mice.
Topics: Adenocarcinoma; Animals; Cecal Neoplasms; Intestinal Neoplasms; Male; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasms, Radiation-Induced; Nitroimidazoles; Rectal Neoplasms | 1978 |
Misonidazole (Ro-07-0582) sensitizes mice to convulsions induced by hyperbaric oxygen or pentylenetetrazol.
Topics: Animals; Drug Synergism; Female; Mice; Misonidazole; Nitroimidazoles; Oxygen; Pentylenetetrazole; Seizures | 1978 |
Monitoring salivary misonidazole in man: a possible alternative to plasma monitoring.
Topics: Adult; Aged; Bronchial Neoplasms; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Misonidazole; Neoplasm Metastasis; Neoplasms; Nitroimidazoles; Saliva; Skin Neoplasms | 1978 |
Effect of local hyperthermia on the acute toxicity of misonidazole in mice.
Topics: Animals; Female; Hot Temperature; Lethal Dose 50; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1979 |
Comparative study of nitroimidazoles on the bioelectric properties of frog skin as a membrane model.
Topics: Animals; In Vitro Techniques; Membrane Potentials; Misonidazole; Nitroimidazoles; Rana temporaria; Skin; Sodium-Potassium-Exchanging ATPase | 1992 |
Hypoxia-specific inhibition of recovery from radiation damage by a novel 2-nitroimidazole with a theophylline side chain.
Topics: Animals; Caffeine; Cell Hypoxia; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Theophylline | 1992 |
Killing of EMT-6 cells by decays from isotopes incorporated on sensitizer adducts.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cobalt Radioisotopes; Gamma Rays; Iodine Radioisotopes; Kinetics; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Tritium; Tumor Cells, Cultured | 1992 |
Increasing the effect of photodynamic therapy on the RIF-1 murine sarcoma, using the bioreductive drugs RSU1069 and RB6145.
Topics: Animals; Indoles; Mice; Misonidazole; Nitroimidazoles; Organometallic Compounds; Photochemotherapy; Sarcoma; Tumor Cells, Cultured | 1992 |
Pharmacologic/pharmacokinetic evaluation of emesis induced by analogs of RSU 1069 and its control by antiemetic agents.
Topics: Animals; Antiemetics; Dogs; Drug Evaluation; Imidazoles; Mice; Misonidazole; Nitroimidazoles; Ondansetron; Radiation-Sensitizing Agents; Vomiting | 1992 |
Modification of alkylating agent induced cell kill by 2-nitroimidazoles in unclamped and clamped SC 9L tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Hypoxia; Cell Survival; Cyclophosphamide; Etanidazole; Ifosfamide; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred F344 | 1992 |
Protection against light-activated photofrin II killing of tumor cells by nitroimidazoles.
Topics: Animals; Dihematoporphyrin Ether; Drug Interactions; Etanidazole; Hematoporphyrins; Lasers; Mice; Misonidazole; Nitroimidazoles; Photochemotherapy; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
Uptake and cytotoxicity of novel nitroimidazole-polyamine conjugates in Ehrlich ascites tumour cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Drug Carriers; Drug Design; Misonidazole; Nitroimidazoles; Polyamines; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Bioreductive therapy.
Topics: Antineoplastic Agents; Cell Hypoxia; Humans; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1992 |
Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; Cell Survival; Combined Modality Therapy; Dose-Response Relationship, Drug; Indolequinones; Indoles; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prodrugs; Tirapazamine; Triazines | 1992 |
Tumor blood flow changes induced by chemical modifiers of radiation response.
Topics: Animals; Antineoplastic Agents; Blood Flow Velocity; Cisplatin; Doxorubicin; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
Topics: Animals; Cell Hypoxia; Combined Modality Therapy; Drug Evaluation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1992 |
Radiosensitizing, toxicological, and pharmacokinetic properties of hydroxamate analogues of nitroimidazoles as bifunctional radiosensitizers/chemical modifiers.
Topics: Animals; Cell Survival; Hydroxamic Acids; Male; Mice; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1992 |
Pharmacokinetic contribution to the improved therapeutic selectivity of a novel bromoethylamino prodrug (RB 6145) of the mixed-function hypoxic cell sensitizer/cytotoxin alpha-(1-aziridinomethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069).
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Female; Half-Life; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Sarcoma, Experimental | 1991 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
A new class of analogues of the bifunctional radiosensitizer alpha-(1-aziridinylmethyl)-2-nitro-1H-imidazole-1-ethanol (RSU 1069): the cycloalkylaziridines.
Topics: Animals; Aziridines; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Fibrosarcoma; Mice; Misonidazole; Molecular Structure; Nitroimidazoles; Oxygen; Pyrans; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1991 |
Radiosensitization of Chinese hamster cells by pimonidazole (Ro 03-8799) at low X-ray doses.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Misonidazole; Nitroimidazoles; Oxygen; Radiation Dosage; Radiation-Sensitizing Agents | 1991 |
Radiosensitization by misonidazole, pimonidazole and azomycin and intracellular uptake in human tumour cell lines.
Topics: Animals; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Cricetinae; Humans; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Compounds; Tumor Cells, Cultured | 1990 |
The evaluation of erythrocyte membrane response to combined treatment of radiation and nitroimidazoles.
Topics: Dose-Response Relationship, Radiation; Erythrocyte Membrane; Fatty Acids, Unsaturated; Glutathione; Humans; Lipid Peroxidation; Malondialdehyde; Misonidazole; Nitroimidazoles; Radiation Tolerance; Sodium-Potassium-Exchanging ATPase | 1990 |
Nitroheterocyclic compounds as radiation sensitizers and bioreductive drugs.
Topics: Antineoplastic Agents; Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1991 |
Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice.
Topics: Administration, Oral; Animals; Combined Modality Therapy; Injections, Intraperitoneal; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1991 |
Addition of 2-nitroimidazole radiosensitizers to cis-diamminedichloroplatinum(II) with radiation and with or without hyperthermia in the murine FSaIIC fibrosarcoma.
Topics: Animals; Cell Survival; Cisplatin; Combined Modality Therapy; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1990 |
KIH-802, an acetohydroxamic acid derivative of 2-nitroimidazole, as a new potent hypoxic cell radiosensitizer: radiosensitizing activity, acute toxicity, and pharmacokinetics.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Etanidazole; Female; Hydroxamic Acids; Hypoxia; Injections, Intravenous; Lethal Dose 50; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1990 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1990 |
Effect of acidic pH on radiosensitization of FSaIIC cells in vitro by misonidazole, etanidazole, or cis-diamminedichloroplatinum (II).
Topics: Animals; Cell Line; Cell Survival; Cisplatin; Etanidazole; Fibrosarcoma; Hydrogen-Ion Concentration; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1990 |
[Radiosensitization by hypoxic cell radiosensitizer--present status of radiosensitizer].
Topics: Cell Hypoxia; Etanidazole; Humans; Misonidazole; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1990 |
Reduction of 2-, 4- and 5-nitroimidazole drugs by hydrogenase 1 in Clostridium pasteurianum.
Topics: Clostridium; Ferredoxins; Flavin Mononucleotide; Flavin-Adenine Dinucleotide; Hydrogenase; Kinetics; Metronidazole; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1990 |
Distribution of pimonidazole and RSU 1069 in tumour and normal tissues.
Topics: Animals; Antineoplastic Agents; Autoradiography; Male; Melanins; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1990 |
Evaluation of nitroimidazole hypoxic cell radiosensitizers in a human tumor cell line high in intracellular glutathione.
Topics: Cell Line; Drug Evaluation, Preclinical; Etanidazole; Glutathione; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Effects of nitroimidazoles on neuronal cells in vitro.
Topics: Animals; Axons; Cell Line; Etanidazole; Intermediate Filaments; Mice; Misonidazole; Neurons; Nitroimidazoles; Radiation-Sensitizing Agents; Rats | 1989 |
Oncogenic transforming potential of nitroimidazole radiosensitizers.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Etanidazole; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1989 |
Radiosensitizing and cytotoxic effects of nitroimidazoles in CHO cells expressing elevated levels of glutathione-S-transferase.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Etanidazole; Glutathione Transferase; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1989 |
Addition of misonidazole, etanidazole, or hyperthermia to treatment with fluosol-DA/carbogen/radiation.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Drug Combinations; Etanidazole; Fibrosarcoma; Fluorocarbons; Hydroxyethyl Starch Derivatives; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
Radiosensitization by a new nucleoside analogue: 1-[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl-2-nitroimidazole (RP-170).
Topics: Animals; Cell Survival; Combined Modality Therapy; Etanidazole; In Vitro Techniques; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1989 |
A new, potent 2-nitroimidazole nucleoside hypoxic cell radiosensitizer, RP170.
Topics: Animals; Cell Survival; Etanidazole; Female; Lethal Dose 50; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Bone marrow toxicity of total-body irradiation combined with radiosensitizers.
Topics: Animals; Bone Marrow; Dogs; Etanidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Whole-Body Irradiation | 1989 |
Bleomycin and misonidazole cytotoxicity.
Topics: Animals; Bleomycin; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Female; Misonidazole; Nitroimidazoles; Ovary; Oxygen | 1985 |
Demonstration of tumor-selective retention of fluorinated nitroimidazole probes by 19F magnetic resonance spectroscopy in vivo.
Topics: Animals; Magnetic Resonance Spectroscopy; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1989 |
A comparison of colorimetric and clonogenic assays for hypoxic-specific toxins with hamster and human cells.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Colorimetry; Drug Screening Assays, Antitumor; Humans; Misonidazole; Nitroimidazoles; Oxygen; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1989 |
Chemosensitization at reduced nitroimidazole concentrations by mixed-function compounds combining 2-nitroimidazole and chloroethylnitrosourea.
Topics: Cell Survival; Cross-Linking Reagents; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Nitrosourea Compounds | 1989 |
Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice.
Topics: Amifostine; Animals; Etanidazole; Lung Neoplasms; Male; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Metastasis; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1988 |
Radiosensitization of human colorectal tumor cells by 4-nitro-5-sulfonatoimidazoles.
Topics: Adenocarcinoma; Cell Line; Cell Survival; Colorectal Neoplasms; Humans; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 1989 |
Cytocidal effects of misonidazole, Ro 03-8799, and RSU-1164 on euoxic and hypoxic BP-8 murine sarcoma cells at normal and elevated temperatures.
Topics: Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Iodine Radioisotopes; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Sarcoma, Experimental; Tumor Cells, Cultured | 1989 |
Oxic and anoxic photodamage triggered at the subcellular level by the synergistic action of haematoporphyrin derivative and nitroimidazoles.
Topics: Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Calcium; Drug Synergism; Hematoporphyrin Derivative; Hematoporphyrins; Metronidazole; Misonidazole; Mitochondria, Liver; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains | 1986 |
Concentrations achieved in human tumors after administration of misonidazole, SR-2508 and Ro 03-8799.
Topics: Aged; Etanidazole; Female; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A comparison of tumor and normal tissue levels of acidic, basic and neutral 2-nitroimidazole radiosensitizers in mice.
Topics: Animals; Etanidazole; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1986 |
Enhancement in the aerobic toxicity of misonidazole and SR-2508 by buthionine sulfoximine and 4-hydroxypyrazole: the role of hydrogen peroxide.
Topics: Buthionine Sulfoximine; Cell Line; Cell Survival; Etanidazole; Glutathione; Humans; Hydrogen Peroxide; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Pyrazoles; Radiation-Sensitizing Agents | 1986 |
The effect of hypoxic cell sensitizers at different irradiation dose rates.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Etanidazole; Lung; Misonidazole; Nitroimidazoles; Regression Analysis | 1987 |
[Present status of hypoxic cell sensitizers and PLDR inhibitors].
Topics: Animals; Cell Cycle; Cell Line; Etanidazole; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1987 |
Interactions of hyperthermia with hypoxic cell sensitisers.
Topics: Animals; Combined Modality Therapy; Etanidazole; Hyperthermia, Induced; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1988 |
[Development of new hypoxic cell radiosensitizer in Japan].
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Etanidazole; Hydroxamic Acids; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1988 |
Changes in ultrastructure and function of hypoxic V79 fibroblast cells after treatment with misonidazole.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Electron Transport Complex IV; Fibroblasts; Hypoxia; Microscopy, Electron; Misonidazole; Mitochondrial Swelling; Nitroimidazoles; Oxygen; Time Factors | 1985 |
Neurotoxicity of Adriamycin and misonidazole in the mouse.
Topics: Animals; Doxorubicin; Lysosomes; Male; Misonidazole; Muridae; Nitroimidazoles; Peripheral Nervous System Diseases; Sciatic Nerve | 1985 |
Fast neutrons and misonidazole for malignant astrocytomas.
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioblastoma; Humans; Male; Middle Aged; Misonidazole; Neutrons; Nitroimidazoles | 1985 |
Adduct formation is involved in radiosensitization, mediated by cytochrome c, of phi X174 DNA by misonidazole.
Topics: Bacteriophage phi X 174; Cytochrome c Group; DNA, Single-Stranded; DNA, Viral; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation Genetics; Radiation Tolerance | 1985 |
Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue.
Topics: Animals; Fluorine; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radioisotopes; Radionuclide Imaging; Rats; Rats, Inbred Strains; Tissue Distribution | 1986 |
Relationship between the neurotoxicity of the hypoxic cell radiosensitizer SR 2508 and the pharmacokinetic profile.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Etanidazole; Humans; Kinetics; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1987 |
An in vitro and in vivo screening system for new hypoxic cell radiosensitizers using EMT6 cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tetrazoles | 1986 |
Selective enhancement of hypoxic cell killing by melphalan via thiol depletion: in vitro studies with hypoxic cell sensitizers and buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Etanidazole; Melphalan; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Sulfhydryl Compounds | 1985 |
The in vitro sensitivity of chronically hypoxic EMT6/SF cells to X-radiation and hypoxic cell radiosensitizers.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Etanidazole; Female; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Sulfhydryl Compounds; X-Rays | 1985 |
[Radiosensitizing effect of the nitroimidazole derivatives RK28 and DNIE on murine tumors].
Topics: Animals; Chemical Phenomena; Chemistry; Drug Evaluation; Lethal Dose 50; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Rabbits; Radiation-Sensitizing Agents | 1988 |
Mechanism of action of some bioreducible 2-nitroimidazoles: comparison of in vitro cytotoxicity and ability to induce DNA strand breakage.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Damage; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Plasmids; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1987 |
DNA damage induced by reductively activated nitroimidazoles--pH effects.
Topics: DNA, Bacterial; Escherichia coli; Hydrogen-Ion Concentration; Metronidazole; Misonidazole; Nitroimidazoles | 1986 |
Misonidazole and benznidazole inhibit hydroxylation of CCNU by mouse liver microsomal cytochrome P-450 in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Misonidazole; Nitroimidazoles; Structure-Activity Relationship | 1987 |
Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.
Topics: Aerobiosis; Animals; Cell Survival; Chlorine; Glutathione; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Structure-Activity Relationship | 1987 |
Distribution of nitroimidazoles and L-phenylalanine mustard in mammary adenocarcinoma 16/C tumors.
Topics: Adenocarcinoma; Animals; Female; Lissamine Green Dyes; Mammary Neoplasms, Experimental; Melphalan; Metronidazole; Mice; Misonidazole; Nitroimidazoles; Time Factors | 1987 |
Platinum complexes with one radiosensitizing ligand [PtCl2(NH3) (sensitizer)]: radiosensitization and toxicity studies in vitro.
Topics: Animals; Cisplatin; Cricetinae; In Vitro Techniques; Metronidazole; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Thiazoles | 1987 |
Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.
Topics: Animals; Carcinoma 256, Walker; Female; Immunohistochemistry; Male; Microscopy, Fluorescence; Misonidazole; Nitroimidazoles; Oxygen; Rabbits; Tumor Cells, Cultured | 1987 |
Altered pharmacokinetics in the mechanism of chemosensitization: effects of nitroimidazoles and other chemical modifiers on the pharmacokinetics, antitumour activity and acute toxicity of selected nitrogen mustards.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Drug Interactions; Hydrolysis; Kinetics; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitrogen Mustard Compounds; Nitroimidazoles; Protein Binding; Sarcoma, Experimental | 1986 |
Effect of radiation-induced reduction of nitroimidazoles on biologically active DNA.
Topics: Coliphages; DNA, Single-Stranded; DNA, Viral; Metronidazole; Misonidazole; Nitroimidazoles; Ornidazole; Oxidation-Reduction; Radiochemistry | 1986 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799.
Topics: Adult; Aged; Animals; Carcinoma, Squamous Cell; Cricetinae; Cricetulus; Female; Humans; Male; Melanoma; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Uterine Cervical Neoplasms | 1986 |
Chromosome-damaging activity of a ruthenium radiosensitizer, RuCl2 (DMSO)2 (4-nitroimidazole)2, in Chinese hamster ovary cells in vitro.
Topics: Animals; Chromosome Aberrations; Cisplatin; Cricetinae; Cricetulus; Female; In Vitro Techniques; Misonidazole; Mutagens; Nitroimidazoles; Organometallic Compounds; Ovary; Radiation-Sensitizing Agents; Ruthenium | 1986 |
Induction of DNA strand breaks by reduced nitroimidazoles. Implications for DNA base damage.
Topics: Deoxyguanosine; DNA; DNA Damage; Glyoxal; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Structure-Activity Relationship | 1986 |
The effect of electron-affinic radiosensitizers on ATP levels in V79 379A Chinese hamster cells.
Topics: 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Cell Line; Cricetinae; Cricetulus; Dinitrophenols; Imidazoles; Metronidazole; Misonidazole; Nitrofurantoin; Nitroimidazoles; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1987 |
In vitro assessment of the oncogenic potential of nitroimidazole radiosensitizers.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; In Vitro Techniques; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange; Time Factors | 1985 |
Combined effect of misonidazole and glutathione depletion by buthionine sulphoximine on cellular radiation response.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cricetinae; Cricetulus; DNA, Single-Stranded; Dose-Response Relationship, Drug; Fibroblasts; Glutathione; Humans; In Vitro Techniques; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Radiation Tolerance | 1985 |
Reactions of nitroimidazoles with free radicals--enhancement of reaction by u.v. irradiation.
Topics: Acrylic Resins; Free Radicals; Metronidazole; Misonidazole; Mutagens; Nitroimidazoles; Ornidazole; Potassium; Potassium Compounds; Radiation-Sensitizing Agents; Sulfates; Ultraviolet Rays | 1985 |
Cellular uptake of misonidazole and analogues with acidic or basic functions.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Extracellular Space; Fibroblasts; Hydrogen-Ion Concentration; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship; Time Factors | 1985 |
The effect of extracellular pH on radiosensitization by misonidazole and acidic or basic analogues.
Topics: Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Cell Survival; Cricetinae; Extracellular Space; Fibroblasts; Hydrogen-Ion Concentration; In Vitro Techniques; Misonidazole; Nimorazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 1985 |
Glutathione requirement for the rejoining of radiation-induced DNA breaks in misonidazole-treated cells.
Topics: Buthionine Sulfoximine; DNA; DNA Repair; DNA, Single-Stranded; Fibroblasts; Glutathione; Humans; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1985 |
Radiosensitizing and cytotoxic properties of misonidazole on glutathione synthetase deficient human fibroblasts.
Topics: Cell Survival; Cesium Radioisotopes; Dose-Response Relationship, Drug; Fibroblasts; Gamma Rays; Glutathione; Glutathione Synthase; Humans; Misonidazole; Nitroimidazoles; Peptide Synthases; Radiation-Sensitizing Agents | 1985 |
The neurotoxicity of radiosensitizing drugs: a biochemical assessment of desmethylmisonidazole (DMM) in the rat.
Topics: Animals; beta-Galactosidase; Brain; Cerebellum; Dose-Response Relationship, Drug; Glucuronidase; Male; Medulla Oblongata; Misonidazole; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains | 1985 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; Heterocyclic Compounds; Hydroxamic Acids; Hypoxia; Lomustine; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Kinetics; Lomustine; Mice; Microsomes, Liver; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1986 |
In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.
Topics: Animals; Combined Modality Therapy; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Tumor Stem Cell Assay | 1985 |
Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.
Topics: Administration, Oral; Animals; Drug Interactions; Fibrosarcoma; Injections, Intraperitoneal; Lethal Dose 50; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1985 |
Factors influencing the chemosensitization of melphalan by misonidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fibrosarcoma; Kinetics; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Temperature | 1985 |
Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.
Topics: Animals; Carbon Radioisotopes; Cell Aggregation; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Structure-Activity Relationship; Tritium | 1985 |
Effect of misonidazole on formation of thymine damage by gamma rays.
Topics: Aerobiosis; Anaerobiosis; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Thymine | 1985 |
Scanning electron microscopy and transmission electron microscopy of the ciliated cells of the trachea of the rabbit treated with misonidazole alone and in combination with ionizing radiation.
Topics: Animals; Cilia; Microscopy, Electron; Misonidazole; Nitroimidazoles; Rabbits; Radiation, Ionizing; Trachea | 1985 |
Regional measurements of [14C]misonidazole distribution and blood flow in subcutaneous RT-9 experimental tumors.
Topics: Animals; Carbon Radioisotopes; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Rats; Regional Blood Flow; Tissue Distribution | 1985 |
Comparison of binding of [3H]misonidazole and [14C]misonidazole in multicell spheroids.
Topics: Animals; Carbon Radioisotopes; In Vitro Techniques; Misonidazole; Models, Biological; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tritium | 1985 |
Further characterization of 4-bromomisonidazole as a potential detector of hypoxic cells.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Misonidazole; Models, Biological; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Late results of multiple fractions per day (MFD) with misonidazole in advanced cancer of the head and neck. A pilot study of the EORTC radiotherapy group.
Topics: Follow-Up Studies; Head and Neck Neoplasms; Humans; Misonidazole; Neoplasm Staging; Nitroimidazoles; Pilot Projects; Radiotherapy Dosage; Time Factors | 1985 |
Chemopotentiation of CCNU metabolites by misonidazole.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles | 1985 |
Comparative distribution of misonidazole and its amine metabolite in female Swiss Webster mice.
Topics: Animals; Female; Mice; Misonidazole; Nitroimidazoles; Tissue Distribution; Tritium | 1985 |
Reaction of the vascular system in the trachea of the rabbit exposed to fractionated irradiation with and without the addition of misonidazole.
Topics: Animals; Blood Vessels; Misonidazole; Nitroimidazoles; Rabbits; Trachea | 1985 |
Effects of glutathione depletion using buthionine sulphoximine on the cytotoxicity of nitroaromatic compounds in mammalian cells in vitro.
Topics: Animals; Buthionine Sulfoximine; Cells, Cultured; Cricetinae; Cricetulus; Glutathione; Methionine Sulfoximine; Misonidazole; Nitrofurantoin; Nitroimidazoles | 1985 |
Changes in misonidazole binding with hypoxic fraction in mouse tumors.
Topics: Animals; Hematocrit; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance | 1985 |
Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer.
Topics: Animals; Brain Neoplasms; Dose-Response Relationship, Radiation; Glioma; Misonidazole; Nitroimidazoles; Oxygen; Rats | 1985 |
Kinetic aspects of misonidazole and its major metabolite in radiotherapy.
Topics: Adult; Aged; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1985 |
Combination of 60Co gamma-radiation, misonidazole, and maltose tetrapalmitate in the treatment of Dunning prostatic tumor in the rat.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Cobalt Radioisotopes; Combined Modality Therapy; Glycolipids; Male; Misonidazole; Nitroimidazoles; Prostatic Neoplasms; Rats | 1985 |
Effect of hypoxic cell radiosensitizers on glutathione level and related enzyme activities in isolated rat hepatocytes.
Topics: Animals; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Hydrogen Peroxide; Hypoxia; Imidazoles; Liver; Male; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Effect of lipophilicity on the rate of diffusion of sensitizers into cellular targets.
Topics: Animals; Cell Survival; Cricetinae; Cricetulus; Diffusion; Membrane Lipids; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1985 |
DNA damage in normal and neoplastic mouse tissues after treatment with misonidazole in vivo.
Topics: Animals; Cell Line; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Fibrosarcoma; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Organ Specificity | 1985 |
Radiosensitizers of hypoxic mammalian cells. 1-(Hydroxyaminoalkyl)-substituted nitroimidazoles.
Topics: Animals; Cell Division; Cells, Cultured; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1985 |
Contrasting effects of cytochrome C on the radiosensitivity of single-stranded phi X174 DNA in the presence of misonidazole or phenol under anoxia.
Topics: Bacteriophage phi X 174; Cobalt Radioisotopes; Cytochrome c Group; DNA, Single-Stranded; DNA, Viral; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Misonidazole; Nitroimidazoles; Oxygen; Phenol; Phenols; Radiation-Protective Agents; Radiation-Sensitizing Agents | 1984 |
Morphological changes in rat hepatocytes in primary culture induced by Misonidazole, desmethylmisonidazole and Ro 03-8799.
Topics: Animals; Cell Survival; Cells, Cultured; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats | 1984 |
Binding to cellular macromolecules as a possible mechanism for the cytotoxicity of misonidazole.
Topics: Ammonium Chloride; Animals; Cricetinae; Cricetulus; DNA; Female; Injections, Intraperitoneal; Macromolecular Substances; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Ovary; Oxidation-Reduction; RNA; Serum Albumin, Bovine; Zinc | 1980 |
Misonidazole-induced thymidine release from DNA.
Topics: Animals; Cattle; DNA; Escherichia coli; Misonidazole; Nitroimidazoles; RNA; Thymidine; Thymine | 1981 |
Enhanced cytotoxicity of antineoplastic agents following prolonged exposure to misonidazole.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cell Line; Cell Survival; Cisplatin; Cricetinae; Cricetulus; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen | 1981 |
Palliation of liver metastases with combined hepatic irradiation and misonidazole. Results of a Radiation Therapy Oncology Group Phase I-II study.
Topics: Adult; Aged; Alkaline Phosphatase; Drug Evaluation; Female; Humans; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Organ Size; Palliative Care; Time Factors | 1981 |
Effects of hypoxic cell radiosensitizers on the activity of ATPases.
Topics: Adenosine Triphosphatases; Animals; Carcinoma, Ehrlich Tumor; Dextran Sulfate; Dextrans; Metronidazole; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Uncoupling Agents | 1981 |
[Radiosensitizing effect of misonidazole on intracranially transplanted tumors in mice and its clinical application (author's transl)].
Topics: Adult; Aged; Animals; Brain Neoplasms; Cobalt Radioisotopes; Female; Glioma; Humans; Male; Mice; Mice, Inbred C57BL; Middle Aged; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1982 |
Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cisplatin; Doxorubicin; Fibroblasts; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation, Ionizing; Vincristine; X-Rays | 1982 |
Misonidazole combined with large-fraction pelvic irradiation in the treatment of patients with advanced pelvic malignancies. Preliminary report of an ongoing RTOG phase I-II study.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Palliative Care; Pelvic Neoplasms; Radiotherapy; Radiotherapy, High-Energy | 1983 |
Hypoxia-enhanced reduction and covalent binding of [2-3H]misonidazole in the perfused rat liver.
Topics: Animals; DNA; Glutathione; Hypoxia; Liver; Male; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen; Perfusion; Protein Binding; Rats; Rats, Inbred Strains; RNA | 1984 |
The current status of drug development of hypoxic cell radiosensitizers and their potential role in gynecologic oncology.
Topics: Adult; Aged; Drug Evaluation; Female; Genital Neoplasms, Female; Humans; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen; Palliative Care; Peripheral Nervous System Diseases; Radiation-Sensitizing Agents | 1984 |
Misonidazole & radiotherapy in the palliative treatment of lung cancer.
Topics: Administration, Oral; Aged; Carcinoma, Bronchogenic; Drug Evaluation; Female; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Palliative Care | 1983 |
Nitrosourea-misonidazole combination chemotherapy: effect on KHT sarcomas, marrow stem cells and gut.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Drug Therapy, Combination; Female; Gastrointestinal Diseases; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Streptozocin | 1982 |
Testing of new hypoxic cell sensitizers in vivo.
Topics: Animals; Drug Evaluation, Preclinical; Etanidazole; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1982 |
A comparison of the cytological effects of three hypoxic cell radiosensitizers.
Topics: Animals; Bromodeoxyuridine; Cell Cycle; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Etanidazole; Lung; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sister Chromatid Exchange | 1982 |
Suppression of cell-mediated immunity by misonidazole.
Topics: Animals; Dinitrofluorobenzene; Drug Hypersensitivity; Female; Hypersensitivity, Delayed; Immunity, Cellular; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Nitroimidazoles; Specific Pathogen-Free Organisms | 1982 |
Clinical perspectives for the use of new hypoxic cell sensitizers.
Topics: Animals; Cyclophosphamide; Dogs; Drug Therapy, Combination; Etanidazole; Humans; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Solubility | 1982 |
Studies on the protection against misonidazole-induced toxicity by antiinflammatory agents.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dexamethasone; Female; Flurbiprofen; Lung; Lung Neoplasms; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Phospholipases; Phospholipases A; Propionates | 1983 |
Inhibition of delayed hypersensitivity by metronidazole and misonidazole.
Topics: Animals; Dinitrofluorobenzene; Drug Hypersensitivity; Female; Hypersensitivity, Delayed; Male; Metronidazole; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Specific Pathogen-Free Organisms | 1983 |
[Studies in radiosensitizing effects of misonidazole and SR-2508 on experimental animal tumors].
Topics: Animals; Etanidazole; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1983 |
Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Etanidazole; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole.
Topics: Aerobiosis; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Etanidazole; Female; Misonidazole; Nitroimidazoles; Ovary; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Time Factors | 1984 |
[Recent advances in hypoxic cell radiosensitizer].
Topics: Animals; Cells, Cultured; Etanidazole; Maleates; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Oxygen Consumption; Radiation-Sensitizing Agents | 1983 |
Clinical trials of radiosensitizers: what should we expect?
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dogs; Dose-Response Relationship, Drug; Drug Evaluation; Drug Evaluation, Preclinical; Etanidazole; Humans; Kinetics; Lethal Dose 50; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Depletion of glutathione in vivo as a method of improving the therapeutic ratio of misonidazole and SR 2508.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Etanidazole; Glutathione; Maleates; Methionine Sulfoximine; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Pharmacokinetics and toxicology of continuously infused nitroimidazoles.
Topics: Animals; Brain; Etanidazole; Female; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system.
Topics: Acetophenones; Cobalt Radioisotopes; Etanidazole; Gamma Rays; Metronidazole; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen; Radiation-Sensitizing Agents | 1984 |
The effects of radiosensitizers on intermediary metabolism in vivo.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenocarcinoma; Animals; Dihydroxyacetone Phosphate; Etanidazole; Glycerophosphates; Hydroxybutyrates; Lactates; Liver; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Pyruvates; Radiation-Sensitizing Agents | 1984 |
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors | 1984 |
A comparison of the ability of some radiosensitizers undergoing clinical trials to act as chemosensitizers.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etanidazole; Fibrosarcoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Reduced fractionation and the potential of hypoxic cell sensitizers in irradiation of malignant epithelial tumors.
Topics: Adenocarcinoma; Carcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Misonidazole; Mouth Neoplasms; Nitroimidazoles; Oropharynx; Pharyngeal Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage; Retrospective Studies | 1980 |
The neurotoxicity of misonidazole: potential modifying role of phenytoin sodium and dexamethasone.
Topics: Central Nervous System Diseases; Dexamethasone; Drug Interactions; Half-Life; Humans; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Phenytoin | 1980 |
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs.
Topics: Adrenal Cortex Hormones; Barbiturates; Brain Neoplasms; Drug Interactions; Female; Glioma; Half-Life; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Phenytoin | 1980 |
Neurotoxicity with desmethylmisonidazole.
Topics: Female; Humans; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases | 1981 |
Role of the intestinal flora in the metabolism of misonidazole.
Topics: Animals; Cecum; Clostridium perfringens; Germ-Free Life; Intestines; Male; Misonidazole; Nitroimidazoles; Rats; Urease | 1980 |
Modification of tumour and host response to cyclophosphamide by misonidazole and by WR 2721.
Topics: Amifostine; Animals; Body Weight; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental | 1981 |
Final report on the United States Phase I Clinical Trial of the hypoxic cell radiosensitizer, misonidazole (Ro-07-0582; NSC #261037).
Topics: Adolescent; Adult; Aged; Central Nervous System Diseases; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Female; Hearing Loss; Humans; Male; Middle Aged; Misonidazole; Nausea; Nitroimidazoles; Peripheral Nervous System Diseases; Vomiting | 1981 |
Sensitising effect of misonidazole on NHIK 1922 cells irradiated in vitro or as solid tumour in athymic nude mice.
Topics: Animals; Cell Line; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Hypoxia; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Protective Agents | 1981 |
Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Female; Lethal Dose 50; Mice; Mice, Inbred BALB C; Misonidazole; Mouth Mucosa; Nitroimidazoles; Organothiophosphorus Compounds; Radiation Injuries, Experimental | 1981 |
Broad-shouldered survival curves of a human melanoma xenograft. Implications for radiation therapy in the absence and presence of misonidazole.
Topics: Animals; Humans; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Transplantation, Heterologous | 1981 |
A biochemical assessment of the neurotoxicity of the radiosensitizing drug misonidazole in the rat.
Topics: Animals; beta-Galactosidase; Body Weight; Cerebellum; Culture Techniques; Female; Glucuronidase; Male; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Trigeminal Nerve | 1981 |
Interaction of radiosensitizers and WR-2721. I. Modification of skin radioprotection.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Female; Lethal Dose 50; Mice; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Oxygen; Radiation Tolerance; Skin | 1982 |
Plasma concentration of misonidazole and peripheral neuropathy.
Topics: Half-Life; Humans; Liver; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases | 1982 |
[Biological studies of proton irradiation under combination with a hypoxic cell sensitizer].
Topics: Animals; Carcinoma, Squamous Cell; Female; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Protons; Radiotherapy, High-Energy; Skin Neoplasms | 1982 |
Radiation-dose dependence of the formation of micronuclei in misonidazole treated cell cultures.
Topics: Animals; Cell Division; Cell Line; Cell Nucleus; Cricetinae; Cricetulus; Fibroblasts; Misonidazole; Nitroimidazoles; Radiation Dosage | 1982 |
The effect of misonidazole combined with WR2721 on tumour response and leucopenia due to cyclophosphamide or melphalan.
Topics: Amifostine; Animals; Cell Survival; Cyclophosphamide; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental | 1982 |
Effect of oxygen and misonidazole on radiation damage in biologically active DNA dissolved in a bacterial extract. Influence of cytochrome c.
Topics: Bacteriophage phi X 174; Cobalt Radioisotopes; Cytochrome c Group; DNA, Single-Stranded; DNA, Viral; Dose-Response Relationship, Radiation; Escherichia coli; Gamma Rays; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Tissue Extracts | 1982 |
Interaction of misonidazole and WR-2721--II. Modification of tumour radiosensitization.
Topics: Amifostine; Animals; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Fibrosarcoma; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Radiation Tolerance; Sarcoma, Experimental | 1983 |
The use of misonidazole in association with a three-fractions per day regimen in advanced head and neck epidermoid cancer. A pilot study.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Erythema; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Peripheral Nervous System Diseases; Pilot Projects; Radiotherapy Dosage | 1983 |
Effect of tumor size on S-2-(3-aminopropylamino)ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide.
Topics: Amifostine; Animals; Cyclophosphamide; Drug Interactions; Drug Therapy, Combination; Extremities; Female; Fibrosarcoma; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Time Factors | 1983 |
Radioprotection combined with hypoxic sensitization during radiotherapy of a solid murine tumor.
Topics: Amifostine; Animals; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Female; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Organothiophosphorus Compounds; Oxygen; Radiotherapy Dosage; Statistics as Topic | 1983 |
Modification of stromal radiosensitivity by misonidazole and WR-2721.
Topics: Adenocarcinoma; Amifostine; Animals; Connective Tissue; Dose-Response Relationship, Radiation; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Organothiophosphorus Compounds; Radiation Tolerance | 1983 |
Time dependence of interaction of misonidazole and WR-2721.
Topics: Amifostine; Animals; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Fibrosarcoma; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Organothiophosphorus Compounds; Sarcoma, Experimental; Time Factors | 1983 |
[Intraoperative radiotherapy in combination with misonidazole; with special reference to the drug concentrations in tumors and normal tissues and to the initial effect of the treatment].
Topics: Adult; Colonic Neoplasms; Glioblastoma; Humans; Intraoperative Care; Intraoperative Period; Middle Aged; Misonidazole; Nitroimidazoles; Rectal Neoplasms; Stomach Neoplasms | 1983 |
[Combined use of amifostine and misonidazole in experimental radiotherapy].
Topics: Amifostine; Animals; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Radiation-Protective Agents | 1983 |
Intravesical administration of misonidazole in bladder carcinoma.
Topics: Humans; Misonidazole; Nitroimidazoles; Urinary Bladder; Urinary Bladder Neoplasms | 1983 |
Modification of the radiation response of the mouse kidney by misonidazole and WR-2721.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Female; Kidney; Mice; Mice, Inbred CBA; Misonidazole; Nitroimidazoles; Organothiophosphorus Compounds; Radiation-Protective Agents; Radiation-Sensitizing Agents; Specific Pathogen-Free Organisms | 1983 |
Combination of misonidazole and lipoic acid on the radiation sensitivity of Bacillus megaterium spores.
Topics: Bacillus megaterium; Gamma Rays; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; Spores, Bacterial; Thioctic Acid | 1984 |
Association of the radiosensitizers metronidazole and misonidazole (RO-07-0582) with bovine serum albumin. Effect of urea and ionic strength.
Topics: Magnetic Resonance Spectroscopy; Metronidazole; Misonidazole; Nitroimidazoles; Osmolar Concentration; Protein Binding; Radiation-Sensitizing Agents; Serum Albumin, Bovine; Urea | 1984 |
Influence of misonidazole on survival of wild-type and radiosensitive mutants of yeast.
Topics: Dose-Response Relationship, Drug; Gamma Rays; Haploidy; Hypoxia; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Saccharomyces cerevisiae | 1983 |
Metabolic potentiation of the radiosensitization of hypoxic bacterial cells afforded by nitroaromatic compounds.
Topics: Acetophenones; Dose-Response Relationship, Radiation; Escherichia coli; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors; Triacetoneamine-N-Oxyl | 1983 |
Protection against misonidazole-induced neuropathy in rats: a biochemical assessment.
Topics: Animals; beta-Galactosidase; Cerebellum; Drug Interactions; Galactosidases; Glucuronidase; Kinetics; Misonidazole; Nitroimidazoles; Peripheral Nerves; Rats; Rats, Inbred Strains; Thiamine; Thiamine Pyrophosphate; Vitamin E | 1983 |
Hypoxic cell sensitizers and heavy charged particle beams may play complementary roles in killing hypoxic tumor cells.
Topics: Animals; Carbon; Combined Modality Therapy; Ions; Misonidazole; Neon; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Particle Accelerators; Radiation-Sensitizing Agents; Radiotherapy, High-Energy; Rats; Relative Biological Effectiveness; Rhabdomyosarcoma | 1984 |
Combination therapy with misonidazole and mitomycin C: lack of chemosensitization of EMT6 tumor cells in vivo or in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Mitomycin; Mitomycins; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
Radiosensitization of Bacillus megaterium spores by combinations of oxygen and misonidazole.
Topics: Bacillus megaterium; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Spores, Bacterial | 1984 |
The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.
Topics: Administration, Oral; Animals; Biological Availability; Dog Diseases; Dogs; Drug Evaluation, Preclinical; Etanidazole; Female; Injections, Intravenous; Kinetics; Male; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 1980 |
SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use.
Topics: Animals; Carcinoma; Cell Line; Central Nervous System; Cricetinae; Dogs; Etanidazole; Female; In Vitro Techniques; Lipid Metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; X-Rays | 1981 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
[The effect of diethyl maleate (DEM) on the radiosensitization by misonidazole (MISO) in experimental animal tumors].
Topics: Animals; Drug Synergism; Maleates; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Enhancement of melphalan-induced tumour cell killing by misonidazole: an interaction of competing mechanisms.
Topics: Animals; Body Temperature; Cell Survival; Drug Synergism; Female; Kinetics; Melphalan; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1984 |
Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro.
Topics: Aerobiosis; Animals; Cell Line; Cell Survival; Kinetics; Lomustine; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen | 1984 |
Chemical modifiers of cancer treatment. Part 1. Banff, Canada, 27 November-1 December, 1983.
Topics: Animals; Combined Modality Therapy; Humans; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Repair of DNA breaks after irradiation in misonidazole or oxygen.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; DNA Repair; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
Increased radiosensitivity of aerobic mammalian cells following pre-incubation with misonidazole in hypoxia.
Topics: Aerobiosis; Anaerobiosis; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
The effect of prolonged high dose misonidazole on tumor response to radiation.
Topics: Animals; Combined Modality Therapy; Dose-Response Relationship, Radiation; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1984 |
Response of an experimental mammary carcinoma to fractionated X-irradiation with misonidazole and microwave hyperthermia.
Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Diathermy; Female; Mammary Neoplasms, Experimental; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Pharmacology and toxicology of sensitizers: mechanism studies.
Topics: Animals; Carcinogens; Humans; Metronidazole; Misonidazole; Mutagens; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents | 1984 |
Metabolism induced binding of 14C-misonidazole to hypoxic cells: kinetic dependence on oxygen concentration and misonidazole concentration.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Binding of misonidazole to V79 spheroids and fragments of Dunning rat prostatic and human colon carcinomas in vitro: diffusion of oxygen and reactive metabolites.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Colonic Neoplasms; Cricetinae; Cricetulus; Diffusion; Humans; In Vitro Techniques; Male; Misonidazole; Models, Biological; Nitroimidazoles; Oxygen; Prostatic Neoplasms; Rats; Tritium | 1984 |
Metabolism and excretion of [3H]misonidazole by hypoxic rat liver.
Topics: Animals; Glutathione; In Vitro Techniques; Liver; Male; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen; Rats; Rats, Inbred Strains; Tritium | 1984 |
Intestinal microflora as potential modifiers of sensitizer activity in vivo.
Topics: Animals; Bacteria; Body Temperature; Combined Modality Therapy; Drug Synergism; Female; Intestines; Lung Neoplasms; Melphalan; Mice; Misonidazole; Nitroimidazoles; Penicillins; Radiation-Sensitizing Agents | 1984 |
Evaluation of desmethylmisonidazole-induced neurotoxicity in the rat using brainstem auditory evoked potentials.
Topics: Anesthesia; Animals; Brain Stem; Evoked Potentials, Auditory; Male; Misonidazole; Nitroimidazoles; Pentobarbital; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Reaction Time | 1984 |
The effect of vitamin B6 on the neurotoxicity and pharmacology of desmethylmisonidazole and misonidazole: clinical and laboratory studies.
Topics: Animals; Humans; Mice; Mice, Inbred Strains; Misonidazole; Nervous System Diseases; Nitroimidazoles; Pyridoxine; Radiation-Sensitizing Agents | 1984 |
The effect of nitroimidazoles on the oxygen consumption rate and respiratory control ratio of beef heart mitochondria.
Topics: Animals; Cattle; Dose-Response Relationship, Drug; Female; Misonidazole; Mitochondria, Heart; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Time Factors | 1984 |
Enhancement of artificial lung metastases by misonidazole.
Topics: Animals; Cell Line; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Interstitial misonidazole. A preliminary report on a new perspective in clinical radiation sensitization and hypoxic cell chemotherapy.
Topics: Aged; Carcinoma, Squamous Cell; Female; Humans; Injections; Male; Melanoma; Middle Aged; Misonidazole; Nitroimidazoles; Skin Neoplasms | 1984 |
Mechanism of melphalan crosslink enhancement by misonidazole pretreatment.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1984 |
The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; RNA, Neoplasm; Sarcoma, Experimental | 1984 |
Enhanced tumor responses through therapies combining CCNU, MISO and radiation.
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drug Therapy, Combination; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
Potentiation of cyclophosphamide cytotoxicity in vivo: a study with misonidazole and fifteen other 1-substituted 2-nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors | 1984 |
Clinical trials with cyclophosphamide and misonidazole combination for maintaining treatment after radiation therapy of lung carcinoma.
Topics: Adult; Aged; Combined Modality Therapy; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Misonidazole neurotoxicity in rats: Part I. Evaluation of misonidazole neurotoxicity in rats by analysis of brain stem auditory and cortical evoked potentials.
Topics: Animals; Auditory Cortex; Brain Diseases; Brain Stem; Cerebral Cortex; Evoked Potentials, Auditory; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains; Reaction Time | 1984 |
Misonidazole neurotoxicity in rats: Part II. Effect of pre- and intermittent treatment with pentobarbital on misonidazole neurotoxicity in the rat.
Topics: Animals; Enzyme Induction; Male; Microsomes, Liver; Misonidazole; Nitroimidazoles; Pentobarbital; Rats; Rats, Inbred Strains | 1984 |
Effects of oxygen and misonidazole on cell transformation and cell killing in C3H 10T1/2 cells by X rays in vitro.
Topics: Aerobiosis; Anaerobiosis; Animals; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Radiation; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
The effect of misonidazole as a hypoxic radiosensitizer at low dose.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
The effect of a hypoxic cell sensitizer on cancer radiotherapy: an analysis by a model.
Topics: Humans; Hypoxia; Mathematics; Misonidazole; Models, Theoretical; Neoplasms; Nitroimidazoles | 1984 |
Effect of misonidazole pretreatment on nitrogen mustard-induced DNA cross-linking in mouse tissues in vivo.
Topics: Animals; Cross-Linking Reagents; DNA; Drug Synergism; Fibrosarcoma; Jejunum; Kidney; Liver; Mechlorethamine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Spleen | 1984 |
Kinetics of misonidazole enantiomers.
Topics: Administration, Oral; Adult; Cimetidine; Drug Interactions; Female; Half-Life; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin; Stereoisomerism | 1984 |
Determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography with reductive electrochemical detection.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Misonidazole; Nitro Compounds; Nitroimidazoles; Spectrophotometry, Ultraviolet | 1984 |
A study of the effects of prior heat treatment on the skin reaction of mouse feet after heat alone or combined with X-rays: influence of misonidazole.
Topics: Animals; Foot; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Misonidazole; Nitroimidazoles; Skin; X-Rays | 1984 |
Radiosensitizing drugs in relation to individualized treatment.
Topics: Alkylating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Hypoxia; In Vitro Techniques; Misonidazole; Neoplasms; Nervous System; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Sulfhydryl Reagents | 1984 |
Combined treatment of radiation and local injections of misonidazole.
Topics: Combined Modality Therapy; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Radiation-induced oxidative denitration of 2-nitroimidazoles in aqueous solution.
Topics: Misonidazole; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Solutions; Water | 1984 |
[Clinical evaluation of radiosensitizing effects of misonidazole].
Topics: Brain Neoplasms; Combined Modality Therapy; Drug Evaluation; Esophageal Neoplasms; Humans; Lung Neoplasms; Misonidazole; Nitroimidazoles | 1984 |
Radiosensitizing effect of combined radiotherapy, hyperthermia and misonidazole on C3H mouse FM3A tumor.
Topics: Animals; Cell Line; Combined Modality Therapy; Female; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1984 |
Enhancement of misonidazole radiosensitization by buthionine sulphoximine.
Topics: Animals; Buthionine Sulfoximine; Combined Modality Therapy; Dose-Response Relationship, Radiation; Drug Synergism; Glutathione; Methionine Sulfoximine; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Skin | 1984 |
The effect of hypoxic radiosensitizer after mild hyperthermia in C3H mammary carcinoma.
Topics: Anaerobiosis; Animals; Combined Modality Therapy; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Polarographic measurement of misonidazole in mouse mammary tumors.
Topics: Animals; Half-Life; Hypoxia; In Vitro Techniques; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Polarography; Tissue Distribution | 1984 |
Detection of a reactive metabolite of misonidazole in hypoxic mammalian cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Female; Guanosine; Misonidazole; Nitroimidazoles; Ovary; Oxygen | 1984 |
Glutathione depletion, radiosensitization, and misonidazole potentiation in hypoxic Chinese hamster ovary cells by buthionine sulfoximine.
Topics: Animals; Buthionine Sulfoximine; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Drug Synergism; Female; Glutathione; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
Misonidazole-glutathione conjugates in CHO cells.
Topics: Animals; Carbon Radioisotopes; Cell Line; Cricetinae; Cricetulus; Female; Glutathione; Liver; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Ovary; Oxygen | 1984 |
Reductive fragmentation of 2-nitroimidazoles: amines and aldehydes.
Topics: Amines; Glyoxal; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Propanolamines | 1984 |
Potentiation of melphalan activity in the KHT sarcoma by the radiosensitizer RSU 1069.
Topics: Animals; Aziridines; Azirines; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
Sister chromatid exchanges and chromosome aberrations induced by radiosensitizing agents in bone marrow cells of treated tumor-bearing mice.
Topics: Animals; Bone Marrow; Cell Line; Chromosome Aberrations; Crossing Over, Genetic; Hot Temperature; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Microwaves; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiotherapy Dosage; Sister Chromatid Exchange | 1983 |
[Radiotherapy in combination with misonidazole and ACNU in lung neoplasms].
Topics: Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nimustine; Nitroimidazoles; Nitrosourea Compounds; Radiotherapy Dosage | 1983 |
Enhancement of misonidazole radiosensitization by an inhibitor of glutathione biosynthesis.
Topics: Animals; Buthionine Sulfoximine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Glutathione; Methionine Sulfoximine; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1983 |
A rapid-mix study on the effect of lipophilicity of nitroimidazoles on the radiosensitization of mammalian cells in vitro.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1983 |
Radiation-induced reduction of nitroimidazole derivatives in aqueous solution.
Topics: Cobalt Radioisotopes; Dose-Response Relationship, Radiation; Gamma Rays; Metronidazole; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents | 1983 |
Dose-independent effect of misonidazole in fractionated irradiations of hypoxic Vicia faba bean roots.
Topics: Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Oxygen; Plants; Radiation-Sensitizing Agents; Time Factors | 1984 |
Electrochemical and pulse radiolysis study of misonidazole and its azo and azoxy derivatives.
Topics: Electrochemistry; Misonidazole; Nitroimidazoles; Pulse Radiolysis | 1984 |
The effect of radiosensitizers on the pharmacokinetics of melphalan and cyclophosphamide in the mouse.
Topics: Animals; Body Temperature; Cell Survival; Cyclophosphamide; Drug Synergism; Female; Half-Life; Kinetics; Male; Melphalan; Mice; Misonidazole; Nitroimidazoles; Time Factors | 1983 |
The labelling of EMT-6 tumours in BALB/C mice with 14C-misonidazole.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Female; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen Consumption; Time Factors; Tissue Distribution | 1983 |
[Clinical studies of combined therapy of radiation and local injection of misonidazole].
Topics: Adult; Aged; Female; Humans; Injections; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Radiotherapy Dosage | 1983 |
The role of dexamethasone in the modification of misonidazole pharmacokinetics.
Topics: Adult; Aged; Dexamethasone; Drug Interactions; Female; Humans; Kinetics; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin | 1983 |
The penetration of misonidazole and desmethylmisonidazole into brain tumours and other central nervous system tissues in man.
Topics: Adolescent; Adult; Aged; Brain; Brain Neoplasms; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Time Factors | 1983 |
The role of microsomal enzyme inducers in the reduction of misonidazole neurotoxicity.
Topics: Adult; Aged; Drug Administration Schedule; Drug Interactions; Enzyme Induction; Half-Life; Humans; Kinetics; Microsomes, Liver; Middle Aged; Misonidazole; Nervous System Diseases; Nitroimidazoles; Phenobarbital; Phenytoin | 1983 |
Radiosensitisation of cells in vitro with misonidazole: dependence on endogenous sulphydryl.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Sulfhydryl Compounds | 1983 |
Misonidazole neurotoxicity in mice decreased by administration with pyridoxine.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Female; In Vitro Techniques; Kinetics; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms, Experimental; Nervous System; Nitroimidazoles; Pyridoxine; Schiff Bases; Time Factors | 1983 |
The topical use of misonidazole in bladder cancer.
Topics: Administration, Oral; Administration, Topical; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Humans; Kinetics; Misonidazole; Mucous Membrane; Nitroimidazoles; Urinary Bladder; Urinary Bladder Neoplasms | 1983 |
[Radiosensitization of hypoxic tumor cells with special reference to head and neck cancers].
Topics: Half-Life; Head and Neck Neoplasms; Humans; Hypoxia; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents | 1983 |
Pharmacokinetic rationale for the interaction of 5-fluorouracil and misonidazole in humans.
Topics: Adult; Aged; Drug Evaluation; Drug Synergism; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Kinetics; Male; Middle Aged; Misonidazole; Nausea; Nitroimidazoles; Time Factors; Vomiting | 1983 |
Cytotoxic properties of hydroxylamino- and amino-misonidazole, possible metabolic products of misonidazole, in hypoxic HeLa S3 cells.
Topics: Antineoplastic Agents; Cells, Cultured; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Oxygen | 1983 |
Inhibition of cell-cycle progression by acute treatment with various degrees of hypoxia: modifications induced by low concentrations of misonidazole present during hypoxia.
Topics: Cell Cycle; Cell Division; Cell Line; DNA; Flow Cytometry; Humans; Interphase; Misonidazole; Nitroimidazoles; Oxygen; Time Factors | 1983 |
In vivo cytotoxicity of misonidazole and hyperthermia in a transplanted mouse mammary tumor.
Topics: Animals; Drug Evaluation, Preclinical; Female; Hyperthermia, Induced; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Temperature; Time Factors | 1983 |
Circadian changes in the elimination of misonidazole in mouse.
Topics: Animals; Circadian Rhythm; Female; Half-Life; Kinetics; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Time Factors | 1983 |
Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole.
Topics: Animals; Bromine; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Radioisotopes; Radionuclide Imaging; Tissue Distribution | 1983 |
[Experimental studies on radiosensitization of hypoxic cancer cells].
Topics: Animals; Carcinoma, Squamous Cell; Female; Humans; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Uterine Cervical Neoplasms | 1983 |
[Flow-microfluorometric studies on the effect of misonidazole as a radiosensitizer for human uterine cervical carcinoma transplanted to nude mice].
Topics: Animals; Carcinoma, Squamous Cell; DNA, Neoplasm; Female; Flow Cytometry; Humans; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Uterine Cervical Neoplasms | 1983 |
[Clinical study on radiotherapy in combination with misonidazole].
Topics: Aged; Esophageal Neoplasms; Female; Humans; Lung Neoplasms; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles; Pharyngeal Neoplasms; Radiation-Sensitizing Agents | 1983 |
[Effect of even or uneven dose fractionation regime on murine squamous cell carcinoma with combined use of misonidazole].
Topics: Animals; Carcinoma, Squamous Cell; Combined Modality Therapy; Fibrosarcoma; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Radiotherapy Dosage | 1983 |
Evoked potentials in rats with misonidazole neurotoxicity. I. Brain stem auditory evoked potentials.
Topics: Animals; Brain; Brain Stem; Cerebellum; Cerebral Ventricles; Evoked Potentials, Auditory; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains | 1983 |
Evoked potentials in rats with misonidazole neurotoxicity. II. Somatosensory evoked potentials.
Topics: Animals; Evoked Potentials, Somatosensory; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains; Somatosensory Cortex; Spinal Cord | 1983 |
Effect of misonidazole on the radiosensitivity and repair of potentially lethal damage of L5178Y ascites tumor cells.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Leukemia L5178; Leukemia, Experimental; Mice; Mice, Inbred DBA; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1983 |
Reductive fragmentation of 2-nitroimidazoles in the presence of nitroreductases--glyoxal formation from misonidazole.
Topics: Acetylcholinesterase; Animals; Cell Line; Cricetinae; Cricetulus; Female; Glyoxylates; L-Lactate Dehydrogenase; Misonidazole; Nitroimidazoles; Ovary; Xanthine Oxidase | 1983 |
[Local administration of radiosensitizer misonidazole].
Topics: Adult; Aged; Animals; Astrocytoma; Brain Neoplasms; Dogs; Drug Implants; Female; Glioma; Humans; Injections, Spinal; Kinetics; Male; Mice; Mice, Inbred C57BL; Misonidazole; Nitroimidazoles; Rats; Silicone Elastomers; Uterine Neoplasms | 1983 |
Enhancement of the DNA cross-linking activity of nitrogen mustard by misonidazole and diethyl maleate in a mouse fibrosarcoma tumor in vivo.
Topics: Animals; DNA, Neoplasm; Drug Administration Schedule; Fibrosarcoma; Kinetics; Maleates; Mechlorethamine; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles | 1984 |
The effect of nitroimidazoles on glucose utilization and lactate accumulation in mouse brain.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Glucose; In Vitro Techniques; Kinetics; Lactates; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
The effect of phenytoin, phenobarbitone, dexamethasone and flurbiprofen on misonidazole neurotoxicity in mice.
Topics: Animals; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Female; Flurbiprofen; Glucuronidase; Mice; Mice, Inbred C57BL; Misonidazole; Nitroimidazoles; Peripheral Nerves; Phenobarbital; Phenytoin; Propionates | 1984 |
Pharmacokinetic considerations of misonidazole in therapeutics.
Topics: Dose-Response Relationship, Drug; Humans; Kinetics; Misonidazole; Nitroimidazoles; Saliva | 1984 |
Enhancement of nitrosourea cytotoxicity by misonidazole in vitro: correlation with carbamoylating potential.
Topics: Alkylating Agents; Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Oxygen; Structure-Activity Relationship | 1984 |
Tumor sensitizing effect by misonidazole in a clinically relevant radiation dose range.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Female; Fibrosarcoma; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation Tolerance; Sarcoma, Experimental; Tumor Stem Cell Assay | 1984 |
Effects of misonidazole on circadian rhythm in oxygen uptake of mouse brain homogenates.
Topics: Animals; Brain; Circadian Rhythm; Male; Mice; Misonidazole; Nitroimidazoles; Oxygen Consumption | 1984 |
The effect on the Km for radiosensitization at 0 degree C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation sensitizing agent misonidazole or oxygen.
Topics: Animals; Cell Survival; Cells, Cultured; Cesium Radioisotopes; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Glutathione; Maleates; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Intestine, Small; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1984 |
On the sensitisation of skin radionecrosis in mice by misonidazole at low doses.
Topics: Animals; Dose-Response Relationship, Radiation; Female; Mice; Misonidazole; Necrosis; Nitroimidazoles; Radiation Dosage; Radiation Injuries, Experimental; Skin | 1984 |
Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles; Oxygen; Rats; Skin Neoplasms; Tumor Stem Cell Assay | 1984 |
In vitro potentiation of BCNU activity in rat brain tumour cells pretreated with misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Cells, Cultured; Drug Synergism; Misonidazole; Nitroimidazoles; Rats | 1984 |
Effect of misonidazole on radiation-induced reduction of DNA bases in deaerated aqueous solution.
Topics: Adenine; Cobalt Radioisotopes; Cytosine; Dose-Response Relationship, Drug; Gamma Rays; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Radiation-Sensitizing Agents; Solutions; Thymine; Water | 1984 |
Combination of misonidazole and m-AMSA: effects on radiation sensitivity and toxicity in E. coli.
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Combinations; Escherichia coli; Misonidazole; Nitroimidazoles; Oxygen; Time Factors | 1982 |
Misonidazole also radiosensitizes some normal tissue.
Topics: Humans; Lymphatic Metastasis; Misonidazole; Mouth Mucosa; Nitroimidazoles; Radiotherapy, High-Energy | 1980 |
Effect of combined misonidazole and accelerated neon ions on a human melanoma transplanted into nude mice.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Female; Male; Melanoma; Mice; Mice, Nude; Misonidazole; Neon; Neoplasm Transplantation; Nitroimidazoles; Radiotherapy, High-Energy; Skin Neoplasms | 1982 |
Activation of misonidazole by rat liver microsomes and purified NADPH-cytochrome c reductase.
Topics: Animals; Binding Sites; Biotransformation; In Vitro Techniques; Male; Microsomes, Liver; Misonidazole; NADPH-Ferrihemoprotein Reductase; Nitrofurantoin; Nitroimidazoles; Protein Binding; Rats; Rats, Inbred Strains | 1982 |
[Treatment with misonidazole and high voltage irradiation of xenotransplanted human carcinomas in nu/nu mice with thymic aplasia].
Topics: Animals; Cobalt Radioisotopes; Female; Genital Neoplasms, Female; Humans; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Ovarian Neoplasms; Radiotherapy, High-Energy; Uterine Cervical Neoplasms; Uterine Neoplasms | 1982 |
Split course multiple daily fractionated radiotherapy schedule combined with misonidazole for the management of grade III and IV gliomas. A pilot feasibility study of the Radiotherapy Group of the EORTC.
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Child; Female; Glioma; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Pilot Projects; Prognosis; Radiotherapy Dosage; Radiotherapy, High-Energy | 1982 |
Responses of cells to radiation sensitizers: methods of analysis.
Topics: Animals; Bacillus megaterium; Cell Line; Cricetinae; Female; Kinetics; Lung; Methods; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Radiation-Sensitizing Agents | 1982 |
Behavioural and ultrastructural studies of desmethylmisonidazole-induced neurotoxicity in mice.
Topics: Animals; Behavior, Animal; Brain; Female; Kinetics; Mice; Mice, Inbred C3H; Microscopy, Electron; Misonidazole; Nervous System; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents | 1983 |
An investigation of the possibility of chemosensitization by clinically achievable concentrations of misonidazole.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Therapy, Combination; Female; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen | 1983 |
Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo.
Topics: Animals; Cross-Linking Reagents; DNA; DNA Repair; DNA, Neoplasm; Fibrosarcoma; Glutathione; Jejunum; Maleates; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Spleen | 1983 |
Effect of misonidazole on the tolerance of the rat spinal cord to daily and multiple fractions per day of X rays.
Topics: Anesthesia; Animals; Dose-Response Relationship, Radiation; Enflurane; Male; Misonidazole; Nitroimidazoles; Oxygen; Pentobarbital; Rats; Rats, Inbred Strains; Spinal Cord; Time Factors | 1983 |
In vitro inhibition of misonidazole toxicity and melphalan chemopotentiation by metyrapone.
Topics: Animals; Cell Division; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Glutathione; Melphalan; Metyrapone; Misonidazole; Nitroimidazoles; Oxygen | 1983 |
Depletion of cellular thiols by misonidazole treatment prevents some post-irradiation repair processes.
Topics: DNA Repair; Fibroblasts; Glutathione; Humans; Misonidazole; Nitroimidazoles; Sulfhydryl Compounds | 1983 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1983 |
Role of glutathione in the hypoxic cell cytotoxicity of misonidazole.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Glutathione; Glutathione Transferase; Hypoxia; Maleates; Misonidazole; Nitroimidazoles; Ovary | 1983 |
Effects of phenytoin, phenobarbital, and ascorbic acid on misonidazole elimination.
Topics: Adult; Ascorbic Acid; Drug Interactions; Female; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Phenobarbital; Phenytoin; Protein Binding | 1983 |
Characteristics of the metabolism-induced binding of misonidazole to hypoxic mammalian cells.
Topics: Anaerobiosis; Animals; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Fibrosarcoma; Kidney; Kinetics; Mice; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Temperature | 1983 |
Combined effects of misonidazole, microwave hyperthermia, and X-rays on the in vivo sister chromatid exchanges and chromosomal abnormalities of the dbrB tumor and on the survival of its host.
Topics: Adenocarcinoma; Animals; Chromosome Aberrations; Crossing Over, Genetic; Female; Hot Temperature; Karyotyping; Mammary Neoplasms, Experimental; Mice; Microwaves; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiotherapy Dosage; Sister Chromatid Exchange; Time Factors; X-Rays | 1983 |
The effects of anesthetics and misonidazole on the development of radiation-induced lung damage in mice.
Topics: Adrenal Cortex Hormones; Anesthetics; Animals; Lung; Male; Mice; Mice, Inbred CBA; Misonidazole; Nitroimidazoles; Phenobarbital; Radiation Injuries, Experimental; Radiation-Protective Agents; Time Factors | 1983 |
Combined application of misonidazole and piotron pions on mouse embryos.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Elementary Particles; Embryo, Mammalian; Female; Fetal Death; Fetal Growth Retardation; Mice; Misonidazole; Nitroimidazoles; Pregnancy; Relative Biological Effectiveness; Teratogens; X-Rays | 1983 |
[Assay of a radiation-sensitizer, misonidazole, by high-performance liquid chromatography].
Topics: Chromatography, High Pressure Liquid; Humans; Misonidazole; Nitroimidazoles | 1983 |
Glutathione conjugates of misonidazole.
Topics: Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Glutathione; Magnetic Resonance Spectroscopy; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1983 |
Modification of guanine derivatives by reduced 2-nitroimidazoles.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Guanine; Guanosine; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Spectrophotometry, Ultraviolet | 1983 |
Pharmacokinetics of the hypoxic radiosensitizers misonidazole and demethylmisonidazole after intraperitoneal administration in humans.
Topics: Female; Humans; Injections, Intraperitoneal; Kinetics; Misonidazole; Nitroimidazoles; Ovarian Neoplasms; Radiation-Sensitizing Agents | 1983 |
No significant effect of metoclopramide on misonidazole elimination in man.
Topics: Adult; Drug Interactions; Female; Humans; Kinetics; Male; Metoclopramide; Misonidazole; Nitroimidazoles | 1983 |
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Kinetics; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds | 1983 |
Influence of heat on the intracellular uptake and radiosensitization of 2-nitroimidazole hypoxic cell sensitizers in vitro.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Female; Hot Temperature; Kinetics; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Radiation Tolerance; Time Factors | 1983 |
Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA; DNA Repair; Dose-Response Relationship, Drug; Drug Synergism; Female; Glutathione; Maleates; Melphalan; Misonidazole; Nitroimidazoles; Ovary; Oxygen | 1983 |
Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Hydrogen-Ion Concentration; Misonidazole; Nitroimidazoles; Ovary; Structure-Activity Relationship; Temperature; Time Factors | 1983 |
Action spectra for ultraviolet photosensitized killing of mammalian cells by misonidazole and para-nitroacetophenone.
Topics: Acetophenones; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Free Radicals; Misonidazole; Nitroimidazoles; Photochemistry; Photolysis; Spectrophotometry, Ultraviolet; Ultraviolet Rays | 1983 |
Influence of hypoxia on the metabolism and excretion of misonidazole by the isolated perfused rat liver--a model system.
Topics: Animals; Chromatography, High Pressure Liquid; Hypoxia; Kinetics; Liver; Male; Misonidazole; Nitroimidazoles; Rats | 1983 |
No significant effect of cimetidine on the pharmacokinetics of misonidazole in man.
Topics: Adult; Cimetidine; Drug Interactions; Female; Guanidines; Humans; Kinetics; Male; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1983 |
Time-dose relationships for simultaneous misonidazole and 1,3-bis(2-chloroethyl)-1-nitrosourea exposures in vitro.
Topics: Animals; Carmustine; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Fibrosarcoma; Mice; Misonidazole; Nitroimidazoles; Time Factors | 1983 |
Regional [14C]misonidazole distribution in experimental RT-9 brain tumors.
Topics: Animals; Autoradiography; Brain Neoplasms; Cerebrovascular Circulation; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Rats; Rats, Inbred F344; Regional Blood Flow; Tissue Distribution | 1983 |
Studies on the action of nitroimidazole drugs. The products of nitroimidazole reduction.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Electrolysis; Metronidazole; Misonidazole; Nitrites; Nitroimidazoles; Oxidation-Reduction; Spectrophotometry | 1983 |
Reduction of nitroheterocyclic compounds by mammalian tissues in vivo.
Topics: Acetamides; Animals; Ethanolamine; Ethanolamines; Germ-Free Life; Male; Metronidazole; Misonidazole; Nitrofurazone; Nitroimidazoles; Oxamic Acid; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
Enhancement of the action of alkylating agents by single high, or chronic low doses of misonidazole.
Topics: Animals; Cell Survival; Cyclophosphamide; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Leukopenia; Melphalan; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental | 1983 |
Phase I trial of intravenous L-phenylalanine mustard plus the sensitizer misonidazole.
Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Male; Melphalan; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1983 |
Systemic, bladder wall, and bladder tumor concentration of misonidazole following intravesical administration in the rat.
Topics: Animals; Chromatography, High Pressure Liquid; Female; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Time Factors; Urinary Bladder; Urinary Bladder Neoplasms | 1983 |
Reduction of misonidazole and its derivatives by xanthine oxidase.
Topics: Hypoxia; In Vitro Techniques; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Xanthine Oxidase | 1981 |
Misonidazole blood and cerebrospinal fluid kinetics in monkeys following intravenous and intrathecal administration.
Topics: Animals; Half-Life; Injections, Intravenous; Injections, Spinal; Kinetics; Macaca mulatta; Male; Misonidazole; Nitroimidazoles | 1981 |
Effects of the xanthine oxidase inhibitor allopurinol on the renal clearance of nitroimidazoles.
Topics: Allopurinol; Animals; Kidney; Kinetics; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Xanthine Oxidase | 1982 |
In situ drug delivery.
Topics: Animals; Capillaries; Carmustine; Half-Life; Misonidazole; Models, Biological; Neoplasms, Experimental; Nitroimidazoles; Rats | 1980 |
Radiosensitizing effect of misonidazole in acute and fractionated irradiation of a human osteosarcoma xenograft.
Topics: Adolescent; Animals; Bone Neoplasms; Dose-Response Relationship, Radiation; Humans; Male; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Osteosarcoma; Transplantation, Heterologous | 1980 |
Modification of the action of misonidazole. I. Effect of TAN on toxicity.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cyclic N-Oxides; DNA; Drug Interactions; Misonidazole; Nitroimidazoles; Oxygen; Time Factors; Triacetoneamine-N-Oxyl | 1980 |
Use of solubilizing agents to study radiosensitization in vitro by compounds of low water solubility.
Topics: Animals; Cell Survival; Cricetinae; Cricetulus; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Ethanol; In Vitro Techniques; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Solvents | 1981 |
Misonidazole enhancement of radiation-induced growth delay in rat rhabdomyosarcoma tumours exposed to accelerated carbon and neon ions.
Topics: Animals; Carbon; Cell Survival; Dose-Response Relationship, Radiation; Energy Transfer; Misonidazole; Neon; Nitroimidazoles; Particle Accelerators; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; Sarcoma, Experimental | 1981 |
Radiosensitization of hypoxic mammalian cells in vitro by some 5-substituted-4-nitroimidazoles.
Topics: Animals; Cell Line; Cells, Cultured; Cricetinae; In Vitro Techniques; Misonidazole; Nitroimidazoles; Oxygen; Pulse Radiolysis; Radiation-Sensitizing Agents | 1981 |
Modification of the action of misonidazole. III. The effect of diamide on toxicity and radiosensitization.
Topics: Animals; Azo Compounds; Cell Line; Cell Survival; Cricetinae; Cricetulus; Diamide; DNA; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Oxygen; Radiation Protection; Radiotherapy | 1981 |
Increased enhancement of tumour response to X-rays and high-LET neon ions by desmethylmisonidazole relative to misonidazole.
Topics: Animals; Dose-Response Relationship, Radiation; Energy Transfer; Misonidazole; Neon; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rhabdomyosarcoma; X-Rays | 1982 |
Influence of misonidazole, anaesthesia, clamping of the leg and stress of the animal during treatment on the radiation-induced skin reaction of mouse feet.
Topics: Anesthesia, General; Animals; Constriction; Leg; Male; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Oxygen; Radiation Injuries, Experimental; Radiation Tolerance; Skin; Stress, Physiological; Time Factors; X-Rays | 1982 |
Post-irradiation defects in newly synthesized DNA: neutrons and electrons compared and the effect of misonidazole.
Topics: Animals; Cell Survival; DNA, Neoplasm; Dose-Response Relationship, Radiation; Electrons; Leukemia L5178; Mice; Misonidazole; Neutrons; Nitroimidazoles; Radiation Genetics; Relative Biological Effectiveness; Time Factors | 1982 |
Effect of excision repair on the mutagenesis of misonidazole.
Topics: DNA Repair; Escherichia coli; Misonidazole; Mutation; Nitroimidazoles; X-Rays | 1980 |
Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.
Topics: Cell Cycle; Cell Line; Cell Survival; Cytological Techniques; Dose-Response Relationship, Drug; Humans; Interphase; Misonidazole; Mitosis; Nitroimidazoles; Oxygen | 1981 |
[The effect of misonidazole on anti-tumor activity of immunized rats that received total body irradiation (author's transl)].
Topics: Animals; Ascitic Fluid; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains; Sarcoma, Yoshida; Whole-Body Irradiation | 1981 |
The effect of temperature on the release of thymidine from DNA during exposure to electrolytically reduced misonidazole.
Topics: DNA, Bacterial; Dose-Response Relationship, Drug; Escherichia coli; Hot Temperature; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Thymidine | 1982 |
Immunosuppression by hypoxic cell radiosensitizers: a phenomenon of potential clinical importance.
Topics: Animals; Cell Survival; Graft Rejection; Heart; Heart Transplantation; Immunity, Cellular; Immunosuppression Therapy; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Rats; Rats, Inbred Strains; Skin Transplantation | 1982 |
Reduced sensitization by misonidazole when recovery from potentially lethal damage is allowed.
Topics: Aerobiosis; Anaerobiosis; DNA Repair; Dose-Response Relationship, Radiation; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Saccharomyces cerevisiae | 1982 |
Comparative studies of hypoxic-cell radiosensitization using artificially hypoxic skin in vivo.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Male; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Skin | 1982 |
The penetration of misonidazole into a mature structural cartilage.
Topics: Animals; Cartilage; Female; Half-Life; Misonidazole; Nitroimidazoles; Rabbits; Time Factors | 1982 |
Fatal misonidazole-induced encephalopathy: an RTOG case report.
Topics: Brain Diseases; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Female; Humans; Middle Aged; Misonidazole; Nitroimidazoles; Palatal Neoplasms; Tongue Neoplasms | 1982 |
Newly synthesized hypoxia-mediated drugs as radiosensitizers and cytotoxic agents.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Glutathione; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1982 |
Comparative misonidazole metabolism in anaerobic bacteria and hypoxic Chinese hamster lung fibroblast (V-79-473) cells.
Topics: Animals; Biotransformation; Cells, Cultured; Cricetinae; Enterobacteriaceae; Fibroblasts; Hypoxia; Lung; Mesocricetus; Misonidazole; Mutagens; Nitroimidazoles; Oxidation-Reduction | 1982 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Effect of misonidazole on radiation injury to mouse spinal cord.
Topics: Animals; Dose-Response Relationship, Radiation; Male; Mice; Misonidazole; Nitroimidazoles; Paralysis; Radiation Injuries, Experimental; Radiotherapy; Spinal Cord | 1982 |
Quantitative cytochemical assessment of the neurotoxicity of misonidazole in the mouse.
Topics: Acrylamide; Acrylamides; Animals; Female; Glucuronidase; Male; Methylmercury Compounds; Mice; Mice, Inbred Strains; Misonidazole; Nitroimidazoles; Sex Factors; Tibial Nerve | 1982 |
Misonidazole enhancement of the action of BCNU and melphalan against human melanoma xenografts.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Carmustine; Cell Line; Drug Synergism; Drug Therapy, Combination; Female; Humans; Male; Melanoma; Melphalan; Mice; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Transplantation, Heterologous | 1982 |
Binding of 14C-misonidazole to hypoxic cells in V79 spheroids.
Topics: Autoradiography; Binding Sites; Cells, Cultured; Dose-Response Relationship, Drug; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Time Factors | 1982 |
Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents.
Topics: Animals; Bone Marrow; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Female; Lethal Dose 50; Leukocyte Count; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Studies on the O-demethylation of misonidazole by rat liver microsomes.
Topics: Animals; Kinetics; Male; Microsomes, Liver; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains | 1982 |
Evaluation of the bioavailability of misonidazole (NSC#261037) in capsule and tablet form and pharmacologic effects of daily dosage.
Topics: Adult; Biological Availability; Capsules; Drug Administration Schedule; Drug Evaluation; Half-Life; Humans; Misonidazole; Neoplasms; Nitroimidazoles; Tablets | 1982 |
Large fraction radiotherapy plus misonidazole for treatment of advanced lung cancer: report of a phase I/II trial.
Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; Lung Neoplasms; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy; Radiotherapy Dosage | 1982 |
Skin sensitization by misonidazole: a demonstration of uniform mild hypoxia.
Topics: Air; Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Male; Mice; Misonidazole; Nitroimidazoles; Oxygen; Skin | 1982 |
Oxygen tension, cellular respiration, and redox state as variables influencing the cytotoxicity of the radiosensitizer misonidazole.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Fibroblasts; Kinetics; Misonidazole; Mutation; Nitroimidazoles; Oxidation-Reduction; Oxygen; Oxygen Consumption; Potassium Cyanide | 1982 |
Pharmacokinetic and anti-tumor studies with the radiosensitizer misonidazole in dogs with spontaneous fibrosarcomas.
Topics: Animals; Dog Diseases; Dogs; Fibrosarcoma; Mandibular Neoplasms; Maxillary Neoplasms; Misonidazole; Mouth Neoplasms; Nitroimidazoles; Palate, Soft | 1982 |
Enhancing effect of pre-treatment of cells with misonidazole in hypoxia on their response to melphalan in air.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dithiothreitol; Dose-Response Relationship, Drug; Drug Synergism; Melphalan; Misonidazole; Nitroimidazoles; Oxygen; Time Factors | 1982 |
The effect of caffeine on the cytotoxicity of misonidazole and some other nitroheterocyclic compounds.
Topics: Animals; Caffeine; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Misonidazole; Nitrofurans; Nitroimidazoles | 1982 |
Misonidazole Neuropathy: a clinical, electrophysiological, and histological study.
Topics: Aged; Carcinoma, Squamous Cell; Electromyography; Female; Humans; Laryngeal Neoplasms; Lung Neoplasms; Male; Median Nerve; Middle Aged; Misonidazole; Nerve Fibers, Myelinated; Nervous System Diseases; Neural Conduction; Neuromuscular Diseases; Nitroimidazoles; Paresthesia; Peroneal Nerve; Pharyngeal Neoplasms; Sensation; Sural Nerve; Tibial Nerve | 1982 |
The effect of misonidazole on the cytotoxicity and DNA cross-linking activity of an activated sulfidocyclophosphamide in hypoxic mouse leukemia cells.
Topics: Anaerobiosis; Animals; Antineoplastic Agents; Cells, Cultured; Cross-Linking Reagents; Cyclophosphamide; DNA, Neoplasm; Drug Interactions; Leukemia L1210; Mice; Misonidazole; Nitroimidazoles; Oxygen | 1982 |
Bromomisonidazole: synthesis and characterization of a new radiosensitizer.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Female; Half-Life; Injections, Intraperitoneal; Injections, Intravenous; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents; Tissue Distribution | 1982 |
Inhibition of glycolysis of mammalian cells by misonidazole and other radiosensitizing drugs. prevention by thiols.
Topics: Anaerobiosis; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Cricetinae; Cricetulus; Cysteamine; Cysteine; Glucose; Glycolysis; Lactates; Lactic Acid; Mice; Misonidazole; Niridazole; Nitro Compounds; Nitroimidazoles; Radiation-Sensitizing Agents; Sulfhydryl Compounds | 1982 |
DNA damage and radiosensitizers: M. luteus sensitive sites for misonidazole-TAN combination.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Cyclic N-Oxides; DNA Repair; Drug Synergism; Micrococcus; Misonidazole; Nitroimidazoles; Radiation Injuries, Experimental; Radiation-Sensitizing Agents; Spin Labels | 1982 |
Effect of hyperthermia and misonidazole on the radiosensitivity of a transplantable murine tumor: influence of factors modifying the fraction of hypoxic cells.
Topics: Anesthesia; Animals; Dose-Response Relationship, Radiation; Hot Temperature; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance | 1982 |
Optimizing the interval between administration of misonidazole and irradiation: an in vitro study.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Half-Life; Misonidazole; Nitroimidazoles; Radiotherapy; Time Factors | 1982 |
A comparative investigation of nimorazole and misonidazole as hypoxic radiosensitizers in a C3H mammary carcinoma in vivo.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Misonidazole; Nimorazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1982 |
A new approach to the use of misonidazole as a radiosensitizer of hypoxic tumour cells.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Humans; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiotherapy Dosage; Urinary Bladder Neoplasms | 1982 |
A comparative study on the radiosensitizing effects and cytotoxic properties of misonidazole and 2,4-dinitroimidazole-1-ethanol in HeLa S3 cells.
Topics: Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Electrons; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1982 |
The feasibility of high-dose multiple daily fractionation and its combination with anoxic cell sensitizers in the treatment of head and neck cancer. A pilot study of the Radiotherapy Group of the EORTC (European Organisation for Research on Treatment of C
Topics: Aged; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Pilot Projects; Prognosis; Radiotherapy Dosage | 1982 |
Sample preparation and a liquid chromatographic assay for misonidazole and desmethylmisonidazole.
Topics: Adult; Chromatography, Liquid; Humans; Misonidazole; Nitroimidazoles | 1982 |
[Increased cytotoxicity of misonidazole by pH reduction and 41 degrees C hyperthermia in Chinese hamster cells].
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Female; Hot Temperature; Hydrogen-Ion Concentration; Misonidazole; Nitroimidazoles; Ovary | 1982 |
[Radiosensitizing effect of misonidazole in radiotherapy for intracranial tumors].
Topics: Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Drug Implants; Female; Glioma; Humans; Male; Mice; Middle Aged; Misonidazole; Nitroimidazoles; Silicone Elastomers | 1982 |
Absorption and distribution of vaginally administered misonidazole.
Topics: Absorption; Female; Humans; Misonidazole; Nitroimidazoles; Suppositories; Tissue Distribution; Vagina | 1982 |
[Enhancement of MeCCNU potency (chemosensitization) by misonidazole in a human melanoma xenograft system].
Topics: Animals; Cell Line; Drug Interactions; Female; Humans; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Semustine | 1982 |
Preliminary results of RTOG phase I/II study of misonidazole and radiation for bladder cancer.
Topics: Aged; Carcinoma, Transitional Cell; Drug Evaluation; Female; Humans; Intestinal Obstruction; Intestine, Small; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy; Radiotherapy Dosage; Urinary Bladder Neoplasms | 1982 |
Combination studies with misonidazole and a cis-platinum complex: cytotoxicity and radiosensitization in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Cricetulus; Drug Synergism; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Time Factors | 1980 |
The relationship between misonidazole cytotoxicity and base composition of DNA.
Topics: Adenine Nucleotides; Animals; Antineoplastic Agents; Base Composition; Cattle; DNA; DNA, Single-Stranded; Misonidazole; Molecular Weight; Nitroimidazoles; Nucleic Acid Renaturation; Oxidation-Reduction; Thymine Nucleotides | 1980 |
The interaction of misonidazole with radiation, chemotherapeutic agents, or heat: a preliminary report.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Cisplatin; Cricetinae; Hot Temperature; Hypoxia; Mechlorethamine; Melphalan; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
Teratogenic and radiosensitizing effects of misonidazole on mouse embryos.
Topics: Abnormalities, Drug-Induced; Abnormalities, Radiation-Induced; Animals; Female; Fetal Growth Retardation; Mice; Misonidazole; Nitroimidazoles; Pregnancy; Radiation-Sensitizing Agents; Teratogens | 1981 |
Effects of misonidazole on tumor cell radiation sensitivity and potentially lethal damage repair in vivo and in vitro.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation Tolerance; Time Factors | 1981 |
Structure-activity relationships of 1-substituted 2-nitroimidazoles: effect of partition coefficient and side-chain hydroxyl groups on radiosensitization in vitro.
Topics: Animals; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Cricetinae; Cricetulus; Dose-Response Relationship, Radiation; Female; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Radiation-Sensitizing Agents; Regression Analysis; Solubility; Structure-Activity Relationship | 1982 |
Ocular absorption and toxicity of a radiosensitizer and its effect on hypoxic cells.
Topics: Animals; Cell Survival; Conjunctiva; Cricetinae; Cricetulus; Eye; Female; In Vitro Techniques; Injections; Injections, Intravenous; Misonidazole; Nitroimidazoles; Oxygen Consumption; Rabbits; Radiation Tolerance; Radiation-Sensitizing Agents; Retinoblastoma | 1982 |
Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Spermatogonia; Time Factors | 1982 |
Acetylcholinesterase and cholinesterase activities in the mouse cerebellum following misonidazole treatment.
Topics: Acetylcholinesterase; Animals; Cerebellum; Cholinesterases; Mice; Mice, Inbred C57BL; Misonidazole; Nitroimidazoles | 1981 |
An investigation in vitro of the chromosomal effects of misonidazole.
Topics: Animals; Cell Survival; Cells, Cultured; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C3H; Misonidazole; Mitotic Index; Nitroimidazoles; Sister Chromatid Exchange; Time Factors | 1980 |
Somatosensory deficits in monkeys treated with misonidazole.
Topics: Animals; Female; Kinetics; Macaca nemestrina; Misonidazole; Neural Conduction; Nitroimidazoles; Peripheral Nerves; Sensory Thresholds | 1981 |
Detection of the amine derivative of misonidazole in human urine by high-pressure liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Female; Humans; Misonidazole; Nitroimidazoles; Spectrophotometry, Ultraviolet | 1981 |
I.V. misonidazole (NSC 261037). Report of initial clinical experience.
Topics: Adult; Aged; Bile; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
Misonidazole dose and tumor level relationships. Effects of individual variation in rate of misonidazole metabolism and absorption from the gastrointestinal tract.
Topics: Biological Availability; Dose-Response Relationship, Drug; Half-Life; Humans; Intestinal Absorption; Kinetics; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
Clinical trials of misonidazole in the United States.
Topics: Drug Evaluation; Head and Neck Neoplasms; Humans; Misonidazole; Neoplasm Metastasis; Neoplasms; Nervous System Diseases; Nitroimidazoles | 1981 |
Pilot study of radiotherapy with misonidazole in head and neck cancer.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nervous System Diseases; Nitroimidazoles; Pilot Projects; Radiotherapy Dosage | 1981 |
A serial study of the concentration of misonidazole in human tumors correlated with histologic structure.
Topics: Adenocarcinoma; Biopsy; Breast Neoplasms; Female; Humans; Male; Misonidazole; Necrosis; Nitroimidazoles; Radiotherapy Dosage | 1981 |
The brain stem auditory evoked response as a tool in neuro-behavioral toxicology and medicine.
Topics: Animals; Auditory Perception; Brain Stem; Electroencephalography; Evoked Potentials, Auditory; Misonidazole; Nitroimidazoles; Rats | 1980 |
The concentration of desmethylmisonidazole in human tumours and in cerebrospinal fluid.
Topics: Breast Neoplasms; Female; Humans; Misonidazole; Necrosis; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Time Factors; Uterine Cervical Neoplasms | 1981 |
Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Drug Synergism; Female; Lactates; Metronidazole; Misonidazole; Nitroimidazoles; Ovary | 1981 |
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Lomustine; Mice; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental; Time Factors | 1981 |
The radiation reduction in misonidazole.
Topics: Chromatography, High Pressure Liquid; Free Radicals; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Spectrum Analysis | 1981 |
The metabolism and pharmacokinetics of the hypoxic cell radiosensitizer and cytotoxic agent, misonidazole, in C3H mice.
Topics: Animals; Autoradiography; Chromatography, Paper; Kinetics; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Oxygen; Polarography; Sarcoma, Experimental; Time Factors; Tissue Distribution | 1981 |
Combinations of radiation and misonidazole in a murine lung tumor model.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Female; Lung; Lung Neoplasms; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radiotherapy; Sarcoma, Experimental; Time Factors | 1981 |
In vitro metabolism of misonidazole.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Hydroxylamines; Misonidazole; Nitroimidazoles; Oxygen; Time Factors | 1981 |
Enhanced cell killing in lewis lung carcinoma and a human pancreatic-carcinoma xenograft by the combination of cytotoxic drugs and misonidazole.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Pancreatic Neoplasms; Transplantation, Heterologous | 1981 |
The effect of dexamethasone on the radiation survival response and misonidazole-induced hypoxic-cell cytotoxicity in Chinese hamster cells V-79-753B in vitro.
Topics: Animals; Cell Cycle; Cell Line; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dexamethasone; Dose-Response Relationship, Drug; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1981 |
Enhancement of the effect of cytotoxic drugs by radiosensitizers.
Topics: Animals; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Fibrosarcoma; In Vitro Techniques; Melphalan; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Urination | 1981 |
Does misonidazole enhance radiation injury to the central nervous system?
Topics: Animals; Brain; Female; Misonidazole; Nitroimidazoles; Oxygen; Radiation Dosage; Rats | 1981 |
Influence of misonidazole on the radiosensitivity of transplantable transitional cell bladder carcinoma in mice.
Topics: Animals; Carcinoma, Transitional Cell; Dose-Response Relationship, Radiation; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Prognosis; Radiation-Sensitizing Agents; Urinary Bladder Neoplasms | 1981 |
Effects of misonidazole, irradiation and hyperthermia on lysosomal enzyme activity in mouse tumours.
Topics: Acid Phosphatase; Animals; Body Temperature; Cell Membrane Permeability; Glucuronidase; Hot Temperature; Lysosomes; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Time Factors | 1981 |
Misonidazole and radiotherapy to treat malignant glioma: a phase II trial of the radiation therapy oncology group.
Topics: Astrocytoma; Brain Neoplasms; Drug Evaluation; Glioma; Humans; Misonidazole; Nitroimidazoles; Prognosis | 1981 |
Combined radiation-protective and radiation-sensitizing agents: II. Radiosensitivity of hypoxic or aerobic Chinese hamster fibroblasts in the presence of cysteamine and misonidazole: implications for the "oxygen effect" (with appendix on calculation of do
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Cysteamine; Dose-Response Relationship, Radiation; Mathematics; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance | 1981 |
Comparison of hyperbaric oxygen and misonidazole in fractionated irradiation of murine tumors.
Topics: Animals; Carcinoma, Squamous Cell; Female; Hyperbaric Oxygenation; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Skin | 1981 |
[Clinical experiences with the radiosensitizer Misonidazol (author's transl)].
Topics: Adolescent; Adult; Aged; Brain Neoplasms; Dexamethasone; Drug Interactions; Esophageal Neoplasms; Exanthema; Female; Glioma; Half-Life; Humans; Male; Middle Aged; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Phenytoin | 1981 |
Enhancing effect of misonidazole on the response of the RIF-1 tumour to cyclophosphamide.
Topics: Animals; Cell Line; Cell Survival; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; Leukocytes; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1981 |
Cellular and chemical reduction products of misonidazole.
Topics: Animals; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Paper; Cricetinae; Cricetulus; Female; Misonidazole; Nitroimidazoles; Ovary; Oxidation-Reduction; Protein Binding | 1981 |
Structure-pharmacokinetic relationships for misonidazole analogues in mice.
Topics: Animals; Enzyme Induction; Kidney; Kinetics; Lipids; Male; Mice; Mice, Inbred BALB C; Microsomes, Liver; Misonidazole; Nitroimidazoles; Solubility; Structure-Activity Relationship | 1981 |
Effects of the hypoxic radiosensitizer misonidazole on normal and irradiated epidermis.
Topics: Animals; Epidermis; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred Strains; Skin | 1981 |
The influence of misonidazole on the radiation response of murine tumors of different size: possible artifacts caused by pentobarbital sodium anesthesia.
Topics: Adenocarcinoma; Anesthesia; Animals; Dose-Response Relationship, Radiation; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Pentobarbital; Radiation-Protective Agents | 1981 |
Action of misonidazole on L5178Y-R and L5178Y-S cells. I. Comparison with antimycin A and potassium cyanide under aerobic conditions.
Topics: Aerobiosis; Animals; Antimycin A; Cell Division; Cell Line; Cell Survival; Cyanides; DNA, Neoplasm; Leukemia L5178; Leukemia, Experimental; Mice; Misonidazole; Nitroimidazoles; Potassium Cyanide | 1981 |
Action of misonidazole on L5178Y-R and L5178Y-S cells. II. Cytotoxicity and radiosensitization under hypoxic conditions.
Topics: Animals; Cell Line; Cell Survival; Leukemia L5178; Leukemia, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Radiation-Sensitizing Agents; X-Rays | 1981 |
Phenytoin-induced changes in the pharmacokinetics of misonidazole in radiotherapy patients.
Topics: Carcinoma, Squamous Cell; Esophageal Neoplasms; Half-Life; Head and Neck Neoplasms; Humans; Kinetics; Misonidazole; Nitroimidazoles; Phenytoin; Time Factors | 1981 |
Simultaneous determination of misonidazole and desmethylmisonidazole in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Misonidazole; Nitroimidazoles; Radiotherapy; Reference Values | 1981 |
Nonlinear pharmacokinetics of misonidazole and desmethylmisonidazole in the isolated perfused rat liver.
Topics: Animals; Dealkylation; Dose-Response Relationship, Drug; Kinetics; Liver; Male; Misonidazole; Models, Biological; Nitroimidazoles; Rats; Rats, Inbred Strains | 1981 |
Radiation-enhanced cytotoxicity of misonidazole.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; X-Rays | 1981 |
Combined effects of misonidazole radiosensitization and hypoxic cell toxicity in mammalian cells.
Topics: Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; X-Rays | 1981 |
The effect of combinations of nitroaromatic and nitroxyl radiosensitizers on the radiation survival response of Chinese hamster cells, V.79-753B, in vitro.
Topics: Acetophenones; Animals; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cyclic N-Oxides; Female; Hypoxia; Misonidazole; Nitroimidazoles; Ovary; Radiation-Sensitizing Agents; Spin Labels | 1981 |
Radiosensitization of tumors and normal tissues by combined treatment with misonidazole and heat.
Topics: Animals; Bone Marrow; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Female; Hot Temperature; Intestinal Mucosa; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Oxygen; Radiation Tolerance; Sarcoma, Experimental; Skin | 1981 |
Mechanism of misonidazole-linked cytotoxicity and altered radiation response: role of cellular thiols.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation Tolerance; Sulfhydryl Compounds | 1981 |
Flurbiprofen, a non-steroid anti-inflammatory agent, protects cells against hypoxic cell radiosensitizers in vitro.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Flurbiprofen; Misonidazole; Nitrofurantoin; Nitroimidazoles; Oxygen; Propionates; Radiation-Sensitizing Agents | 1981 |
Interactions between misonidazole and hyperthermia in EMT6 spheroids.
Topics: Cell Survival; Cells, Cultured; Hot Temperature; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Time Factors | 1981 |
Effect of prolonged exposure of HELA S3 cells to low concentrations of misonidazole.
Topics: Anaerobiosis; Cell Adhesion; Cell Division; Cell Survival; Dose-Response Relationship, Drug; HeLa Cells; Humans; Kinetics; Misonidazole; Nitroimidazoles | 1981 |
The value of adjuvant misonidazole in the definitive irradiation of advanced head and neck squamous cancer: an RTOG pilot study (#78-02).
Topics: Aged; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Mouth Neoplasms; Nausea; Neoplasm Recurrence, Local; Neoplasm Staging; Nitroimidazoles; Paresthesia; Pharyngeal Neoplasms; Prognosis | 1981 |
[Radiosensitization of C3H/He mammary carcinoma by administration of hyperthermia and/or of misonidazole (author's transl)].
Topics: Animals; Female; Hot Temperature; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1981 |
The effect of misonidazole on some physiologic parameters in mice.
Topics: Animals; Body Temperature; Depression, Chemical; Dose-Response Relationship, Drug; Female; Heart Rate; Hexobarbital; Humans; Kinetics; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Respiration | 1980 |
Is tumour radiosensitization by misonidazole a general phenomenon?
Topics: Animals; Carcinoma; Cell Line; Dose-Response Relationship, Radiation; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation Tolerance; Sarcoma, Experimental; Time Factors | 1980 |
Effect of misonidazole and hyperthermia on the radiosensitivity of a C3H mouse mammary carcinoma and its surrounding normal tissue.
Topics: Animals; Dose-Response Relationship, Drug; Female; Hot Temperature; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation Tolerance; Skin; Time Factors | 1980 |
Causes of apparent low levels of misonidazole in human tumours.
Topics: Adipose Tissue; Animals; Brain Neoplasms; Humans; In Vitro Techniques; Liver Neoplasms; Mammary Neoplasms, Experimental; Mice; Misonidazole; Muscles; Neoplasms; Nitroimidazoles; Rats | 1980 |
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.
Topics: Animals; Biological Availability; Dog Diseases; Dogs; Half-Life; Kinetics; Male; Misonidazole; Neoplasms; Nitroimidazoles | 1980 |
Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.
Topics: Brain Neoplasms; Half-Life; Humans; Kinetics; Misonidazole; Nitroimidazoles; Phenytoin | 1980 |
Mitochondrial alterations produced by misonidazole: a study using Amoeba proteus as a single-cell model.
Topics: Amoeba; Animals; Cytoplasmic Granules; Microscopy, Electron; Misonidazole; Mitochondria; Models, Biological; Nitroimidazoles | 1980 |
The influence of two radiosensitizers on the induction of chromosome aberrations in human lymphocytes by X-radiation.
Topics: Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Lymphocytes; Male; Metronidazole; Misonidazole; Nitroimidazoles; Oxygen; X-Rays | 1980 |
Hypoxic-cell sensitizers and sister chromatid exchanges.
Topics: Crossing Over, Genetic; Humans; Lymphocytes; Male; Metronidazole; Misonidazole; Nitroimidazoles; Sister Chromatid Exchange | 1980 |
Care with radiosensitizers.
Topics: Animals; Mice; Misonidazole; Nitroimidazoles; Skin | 1980 |
Multiple daily fractionation (MDF) radiotherapy in association with hyperthermia and/or misonidazole: experimental and clinical results.
Topics: Animals; Drug Administration Schedule; Head and Neck Neoplasms; Humans; Hyperthermia, Induced; Lymphatic Metastasis; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation Dosage; Radiotherapy; Time Factors | 1980 |
Phenytoin-misonidazole: possible metabolic interaction.
Topics: Drug Evaluation; Drug Interactions; Half-Life; Humans; Infusions, Parenteral; Liver; Misonidazole; Nitroimidazoles; Phenytoin | 1980 |
Effect of acute and chronic misonidazole administration on peripheral-nerve electrophysiology in mice.
Topics: Animals; Drug Administration Schedule; Female; Mice; Misonidazole; Neoplasms, Experimental; Neural Conduction; Nitroimidazoles; Sural Nerve; Tibial Nerve | 1980 |
Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.
Topics: Abdomen; Anesthesia; Animals; Drug Administration Schedule; Drug Interactions; Half-Life; Hindlimb; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Pentobarbital; Transplantation, Homologous | 1980 |
Binding of nitroreduction products of misonidazole to nucleic acids and protein.
Topics: Ammonium Chloride; Animals; Cattle; Chromatography, Affinity; DNA; Hydroxylamines; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Protein Binding; Serum Albumin, Bovine; Spectrophotometry, Ultraviolet; Zinc | 1980 |
Respiratory effects and ascorbate reactions with misonidazole and other recently developed drugs.
Topics: Animals; Cyanides; Dose-Response Relationship, Drug; Kinetics; Metronidazole; Microsomes, Liver; Misonidazole; Nitro Compounds; Nitroimidazoles; Oxygen Consumption; Rats; Sulfhydryl Compounds | 1980 |
Oncogenic transformations in vitro produced by misonidazole.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1980 |
Misonidazole cytotoxicity in vivo: a comparison of large single doses with smaller doses and extended contact of the drug with tumor cells.
Topics: Animals; Body Temperature; Dose-Response Relationship, Drug; Infusions, Parenteral; Injections, Intraperitoneal; Kinetics; Mammary Neoplasms, Experimental; Mice; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Oxygen; Time Factors; Transplantation, Homologous | 1980 |
Effect of combined misonidazole and d(50)-Be neutrons on a human melanoma transplanted into nude mice.
Topics: Animals; Cell Line; Cell Survival; DNA Repair; Fast Neutrons; Half-Life; Humans; Injections, Intraperitoneal; Melanoma; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Neutrons; Nitroimidazoles; Radiotherapy Dosage; Time Factors; Transplantation, Heterologous | 1980 |
Interaction of misonidazole and oxygen in the radiosensitization of mammalian cells.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; Female; Misonidazole; Nitroimidazoles; Ovary; Oxygen | 1980 |
Effect of size of lymph node metastases on the radiation response: influence of misonidazole.
Topics: Animals; Cell Count; Female; Gamma Rays; Injections, Intraperitoneal; Lymph Nodes; Lymphatic Metastasis; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Misonidazole; Nitroimidazoles; Organ Size; Time Factors | 1980 |
Effect of hypoxia on the cytotoxicity of misonidazole in HELA S3 cells in vitro.
Topics: Animals; Cell Survival; Cricetinae; Culture Media; Gamma Rays; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1980 |
Effects of misonidazole on purine metabolism in Ehrlich ascites tumor cells in vitro.
Topics: Adenine; Adenosine Triphosphate; Aerobiosis; Anaerobiosis; Animals; Carcinoma, Ehrlich Tumor; Deoxyglucose; Glucose; In Vitro Techniques; Misonidazole; Nitroimidazoles; Purines | 1980 |
Sulphydryls, ascorbate and oxygen as modifiers of the toxicity and metabolism of misonidazole in vitro.
Topics: Animals; Ascorbic Acid; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cysteamine; Female; Glutathione; HeLa Cells; Humans; Misonidazole; Nitroimidazoles; Ovary; Oxygen; Time Factors | 1980 |
A drug for improved radiosensitization in radiotherapy.
Topics: Half-Life; Humans; Male; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
The neurotoxicity of misonidazole: potential modifying role of dexamethasone.
Topics: Animals; Dexamethasone; Humans; Lethal Dose 50; Male; Mice; Mice, Inbred C3H; Misonidazole; Nervous System; Nitroimidazoles | 1980 |
Misonidazole in fractionated radiotherapy: are many small fractions best?
Topics: Animals; Cell Survival; Drug Administration Schedule; Female; Male; Misonidazole; Models, Biological; Neoplasms; Nitroimidazoles; Oxygen; Radiotherapy Dosage | 1980 |
Testing of hypoxic cell radiosensitizers in vivo.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Humans; Hypoxia; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
The effect of misonidazole in situ on the radiation response of selected tumor subpopoulations.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Female; Fibrosarcoma; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1980 |
Effects of long contact times of misonidazole on attached Chinese hamster V79 cells.
Topics: Animals; Cell Cycle; Cell Line; Chromatids; Cricetinae; Cricetulus; Crossing Over, Genetic; Dose-Response Relationship, Drug; Lung; Misonidazole; Nitroimidazoles; Sister Chromatid Exchange; Time Factors | 1980 |
Plasma concentrations of misonidazole.
Topics: Dose-Response Relationship, Drug; Female; Half-Life; Humans; Male; Misonidazole; Nitroimidazoles; Sex Factors; Time Factors | 1980 |
The radioprotective effect of misonidazole (Ro-07-0582) on normal canine rectum.
Topics: Animals; Dogs; Female; Male; Misonidazole; Nitroimidazoles; Radiation Dosage; Radiation-Protective Agents; Rectum; Time Factors | 1980 |
[Clinical experience with daily doses of misonidazole (author's transl)].
Topics: Adult; Aged; Breast Neoplasms; Female; Genital Neoplasms, Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nervous System; Nitroimidazoles; Time Factors | 1980 |
Drug interactions with misonidazole: effects of dexamethasone and its derivatives on the pharmacokinetics and toxicity of misonidazole in mice.
Topics: Animals; Body Temperature; Brain; Dexamethasone; Drug Interactions; Kinetics; Lethal Dose 50; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sleep | 1980 |
Loss of hearing after misonidazole.
Topics: Aged; Deafness; Female; Humans; Misonidazole; Nitroimidazoles | 1980 |
The response of EMT6 tumor spheroids to combined treatment with misonidazole and either nitrogen mustard, adriamycin, or BCNU.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; In Vitro Techniques; Mammary Neoplasms, Experimental; Mechlorethamine; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
The effects of misonidazole during continuous low dose rate irradiation.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Half-Life; Injections, Intraperitoneal; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1980 |
Effects of metronidazole and misonidazole on some metabolic parameters of normal tissues in mice.
Topics: Animals; Body Temperature; Energy Metabolism; Male; Metronidazole; Mice; Misonidazole; Nitroimidazoles; Oxygen Consumption | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin.
Topics: Animals; Body Weight; Doxorubicin; Drug Therapy, Combination; Fibrosarcoma; Fluorouracil; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Methotrexate; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1980 |
In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: cyclophosphamide and BCNU.
Topics: Animals; Body Weight; Carmustine; Cyclophosphamide; Drug Therapy, Combination; Fibrosarcoma; Leukocyte Count; Male; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1980 |
A biochemical method for assessing the neurotoxic effects of misonidazole in the rat.
Topics: Animals; Cerebellum; Dose-Response Relationship, Drug; Female; Galactosidases; Glucuronidase; Male; Methods; Misonidazole; Neurons; Nitroimidazoles; Rats; Sciatic Nerve; Time Factors; Trigeminal Nerve | 1980 |
In vivo response of KHT sarcomas to combination chemotherapy with radiosensitizers and BCNU.
Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1981 |
Dose-dependence and related studies on the pharmacokinetics of misonidazole and desmethylmisonidazole in mice.
Topics: Animals; Biological Availability; Body Temperature; Dose-Response Relationship, Drug; Female; Half-Life; Kinetics; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Phenobarbital; Premedication; Sex Factors; Skin Neoplasms | 1980 |
Cytotoxic and radiosensitizing effects of misonidazole on hematopoiesis in normal and tumor-bearing mice.
Topics: Animals; Colony-Forming Units Assay; Dose-Response Relationship, Radiation; Hematopoiesis; Hematopoietic Stem Cells; Hypoxia; Lung Neoplasms; Male; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles | 1980 |
The mechanism of binding of the radiosensitizers metronidazole and misonidazole (Ro-07-0582) to bovine and human serum albumin--a proton NMR study.
Topics: Animals; Cattle; Humans; Magnetic Resonance Spectroscopy; Metronidazole; Misonidazole; Nitroimidazoles; Protein Binding; Serum Albumin; Serum Albumin, Bovine | 1981 |
Nature and incidence of misonidazole-produced ototoxicity.
Topics: Adult; Aged; Female; Hearing Loss, Sensorineural; Humans; Male; Middle Aged; Misonidazole; Neoplasms; Nitroimidazoles | 1981 |
Enhancement of antitumor activity of alkylating agents by the radiation sensitizer misonidazole.
Topics: Alkylating Agents; Animals; Aziridines; Benzoquinones; Cyclohexenes; Cyclophosphamide; Drug Therapy, Combination; Female; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Quinones; Semustine | 1980 |
Development of F-18-labeled fluoroerythronitroimidazole as a PET agent for imaging tumor hypoxia.
Topics: Animals; Autoradiography; Cell Hypoxia; Contrast Media; Female; Fluorine Radioisotopes; Male; Mammary Neoplasms, Experimental; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Rabbits; Rats; Rats, Inbred F344; Tissue Distribution; Tomography, Emission-Computed | 1995 |
[Radiosensitizing effects of nitroimidazole derivative, KIN-804].
Topics: Animals; Carcinoma, Squamous Cell; Hydroxamic Acids; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Skin Neoplasms | 1995 |
Metabolic studies and neurotoxicity in tumors and brain of mice after hypoxic cell sensitizers.
Topics: Adenosine Triphosphate; Animals; Brain; Etanidazole; Glucose; Male; Mice; Mice, Inbred C57BL; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nucleosides; Radiation-Sensitizing Agents | 1994 |
Radiosensitizing activity and pharmacokinetics of multiple dose administered KU-2285 in peripheral nerve tissue in mice.
Topics: Animals; Carcinoma, Squamous Cell; Etanidazole; Female; Male; Mice; Mice, Inbred C3H; Mice, Inbred ICR; Misonidazole; Nitroimidazoles; Peripheral Nerves; Radiation-Sensitizing Agents | 1994 |
In vivo radiosensitizing effect of nitroimidazole derivative KIN-804.
Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Hydroxamic Acids; Lethal Dose 50; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents | 1994 |
Comparing the anti-tumor effect of several bioreductive drugs when used in combination with photodynamic therapy (PDT).
Topics: Animals; Antineoplastic Agents; Mice; Mice, Inbred C3H; Misonidazole; Mitomycin; Nitroimidazoles; Photochemotherapy; Sarcoma, Experimental | 1994 |
The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles.
Topics: Animals; Biotransformation; Cells, Cultured; Haplorhini; Kidney; Misonidazole; NAD(P)H Dehydrogenase (Quinone); NADPH-Ferrihemoprotein Reductase; Nitroimidazoles | 1994 |
Bioreductive metabolism of AF-2[2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide] combined with 2-nitroimidazoles. Implications for use as hypoxic cell markers.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cell Line; Drug Interactions; Etanidazole; Furylfuramide; Glucose; Guinea Pigs; Misonidazole; Nitroimidazoles; Oxidation-Reduction; Oxygen Consumption; Rats; Tumor Cells, Cultured | 1993 |
Synthesis of the enantiomers of the bioreductively-activated cytotoxin RSU-1069 and its prodrug RB6145 and lack of stereoselectivity in their cytotoxicity and radiosensitization in vitro.
Topics: Antineoplastic Agents; Misonidazole; Nitroimidazoles; Prodrugs; Radiation-Sensitizing Agents; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
Topics: Acridines; Animals; Cell Hypoxia; Cell Membrane; Cricetinae; Cricetulus; Diffusion; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Phenanthridines | 1996 |
Development of new markers for hypoxic cells: [131I]Iodomisonidazole and [131I]Iodoerythronitroimidazole.
Topics: Animals; Breast Neoplasms; Cell Hypoxia; Female; Iodine Radioisotopes; Lung Neoplasms; Mice; Mice, Inbred BALB C; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Rats; Rats, Inbred F344; Tissue Distribution; Tumor Cells, Cultured | 1996 |
Evaluation of [131I]iodoerythronitroimidazole as a predictor for the radiosensitizing effect.
Topics: Animals; Cell Transplantation; Female; Iodine Radioisotopes; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Predictive Value of Tests; Radiation-Sensitizing Agents; Radiopharmaceuticals; Tumor Cells, Cultured | 1996 |
The radiosensitizing effects of hypoxic cell sensitizer on SCCVII tumors in mice evaluated by highly accurate colony formation assay assisted by microcomputer.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Cell Survival; Etanidazole; Male; Mice; Mice, Inbred C3H; Microcomputers; Misonidazole; Nitroimidazoles; Radiation Tolerance; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
A comparison of the physiological effects of RSU1069 and RB6145 in the SCCVII murine tumour.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred C3H; Misonidazole; Neovascularization, Pathologic; Nitroimidazoles; Oxygen; Phosphorus Radioisotopes | 1996 |
Mitochondrial respiratory chain features after gamma-irradiation.
Topics: Animals; Cattle; Chromatography, Gas; Chromatography, High Pressure Liquid; Electron Transport; Etanidazole; Gamma Rays; Misonidazole; Mitochondria, Heart; Nitroimidazoles; Spectrophotometry; Succinate Dehydrogenase; Ubiquinone | 1997 |
Delineation of the border zone of ischemic rabbit myocardium by a technetium-labeled nitroimidazole.
Topics: Animals; Antimetabolites; Autoradiography; Deoxyglucose; Heart; Hemodynamics; Image Processing, Computer-Assisted; Male; Misonidazole; Myocardial Ischemia; Nitroimidazoles; Organotechnetium Compounds; Rabbits; Radiation-Sensitizing Agents; Radionuclide Imaging; Radiopharmaceuticals | 1997 |
Synthesis and radioiodination of a nido-1,2-carboranyl derivative of 2-nitroimidazole.
Topics: Boron Compounds; Boron Neutron Capture Therapy; Chromatography, High Pressure Liquid; Iodine Radioisotopes; Isotope Labeling; Misonidazole; Nitroimidazoles; Stereoisomerism | 1994 |
Bioreductive therapies: an overview of drugs and their mechanisms of action.
Topics: Animals; Antineoplastic Agents; Aziridines; Cell Hypoxia; DNA, Neoplasm; Forecasting; Humans; Indolequinones; Indoles; Misonidazole; Mitomycin; Nitrofurans; Nitroimidazoles; Oxidation-Reduction; Prodrugs; Radiation-Sensitizing Agents; Tirapazamine; Triazines | 1998 |
Electron affinic sensitization. V. Radiosensitization of hypoxic bacteria and mammalian cells in vitro by some nitroimidazoles and nitropyrazoles.
Topics: Aerobiosis; Animals; Cell Hypoxia; CHO Cells; Cricetinae; Cricetulus; Culture Media; Dose-Response Relationship, Drug; Electrons; Misonidazole; Molecular Structure; Nitro Compounds; Nitroimidazoles; Oxygen; Pyrazoles; Radiation-Sensitizing Agents; Serratia marcescens | 1974 |
Hypoxic cell radiosensitizers: comparative tests of some electron affinic compounds using epidermal cell survival in vivo.
Topics: Animals; Cell Hypoxia; Dithioerythritol; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Evaluation, Preclinical; Electrons; Epidermal Cells; Epidermis; Female; Lethal Dose 50; Male; Metronidazole; Mice; Misonidazole; Nitrofurans; Nitrogen; Nitroimidazoles; Oxygen; Particle Accelerators; Radiation-Protective Agents; Radiation-Sensitizing Agents; Tiopronin; Wound Healing | 1974 |
Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent.
Topics: Animals; Biotransformation; Chemical Phenomena; Chemistry, Physical; CHO Cells; Cricetinae; Electrons; Fluorine Radioisotopes; Hypoxia, Brain; Lipids; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution | 2002 |
Oxygen-sensitive enzyme-prodrug gene therapy for the eradication of radiation-resistant solid tumours.
Topics: Animals; Combined Modality Therapy; Female; Fibrosarcoma; Genetic Therapy; Genetic Vectors; Humans; Hypoxia; Mice; Mice, Nude; Misonidazole; NADPH-Ferrihemoprotein Reductase; Neoplasm Transplantation; Nitroimidazoles; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
The range of oxygenation in SiHa tumor xenografts.
Topics: Animals; Carcinoma; Cell Survival; Comet Assay; DNA Damage; Female; Humans; In Vitro Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Misonidazole; Nitroimidazoles; Oxygen Consumption; Radiation-Sensitizing Agents; Transplantation, Heterologous; Uterine Cervical Neoplasms | 2002 |
DNA-targeted 2-nitroimidazoles: studies of the influence of the phenanthridine-linked nitroimidazoles, 2-NLP-3 and 2-NLP-4, on DNA damage induced by ionizing radiation.
Topics: Animals; Cattle; Cell Hypoxia; CHO Cells; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Gamma Rays; Intercalating Agents; Misonidazole; Nitroimidazoles; Oxygen; Phenanthridines; Radiation-Sensitizing Agents; Structure-Activity Relationship | 2002 |
18F-Fluoroerythronitroimidazole radiation dosimetry in cancer studies.
Topics: Female; Fluorine Radioisotopes; Humans; Male; Misonidazole; Neoplasms; Nitroimidazoles; Radiation Dosage; Radiopharmaceuticals; Tomography, Emission-Computed | 2002 |
Iodine-124-labeled iodo-azomycin-galactoside imaging of tumor hypoxia in mice with serial microPET scanning.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Female; Fibrosarcoma; Mammary Neoplasms, Animal; Metabolic Clearance Rate; Mice; Mice, Inbred C3H; Misonidazole; Monosaccharides; Nitroimidazoles; Organ Specificity; Tissue Distribution; Tomography, Emission-Computed | 2004 |
Comparison of the biodistribution of two hypoxia markers [18F]FETNIM and [18F]FMISO in an experimental mammary carcinoma.
Topics: Animals; Cell Hypoxia; Female; Fluorine Radioisotopes; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Mice; Misonidazole; Nitroimidazoles; Organ Specificity; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2004 |
Evaluation of hypoxia in an experimental rat tumour model by [(18)F]fluoromisonidazole PET and immunohistochemistry.
Topics: Animals; Antibodies, Monoclonal; Carbonic Anhydrase III; Cell Hypoxia; Fluorodeoxyglucose F18; Heart; Immunoenzyme Techniques; Lung; Male; Misonidazole; Muscles; Nitroimidazoles; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rhabdomyosarcoma | 2004 |
Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.
Topics: Animals; Cell Hypoxia; Disease Models, Animal; Female; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Organ Specificity; Oxidation-Reduction; Oxygen; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2005 |
Assessment of regional tumor hypoxia using 18F-fluoromisonidazole and 64Cu(II)-diacetyl-bis(N4-methylthiosemicarbazone) positron emission tomography: Comparative study featuring microPET imaging, Po2 probe measurement, autoradiography, and fluorescent mic
Topics: Animals; Autoradiography; Benzimidazoles; Cell Hypoxia; Coordination Complexes; Fluorodeoxyglucose F18; Humans; Immunohistochemistry; Male; Microscopy, Fluorescence; Misonidazole; Neoplasms; Nitroimidazoles; Organometallic Compounds; Positron-Emission Tomography; Radiation-Sensitizing Agents; Radiopharmaceuticals; Rats; Rats, Nude; Thiosemicarbazones; Transplantation, Heterologous | 2005 |
Imaging hypoxia after oxygenation-modification: comparing [18F]FMISO autoradiography with pimonidazole immunohistochemistry in human xenograft tumors.
Topics: Animals; Autoradiography; Carcinoma, Squamous Cell; Cell Hypoxia; Fluorine Radioisotopes; Glioblastoma; Head and Neck Neoplasms; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Nude; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Radionuclide Imaging | 2006 |
Combined uptake of [18F]FDG and [18F]FMISO correlates with radiation therapy outcome in head-and-neck cancer patients.
Topics: Aged; Cell Hypoxia; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Treatment Outcome | 2006 |
Tumor hypoxia imaging in orthotopic liver tumors and peritoneal metastasis: a comparative study featuring dynamic 18F-MISO and 124I-IAZG PET in the same study cohort.
Topics: Animals; Disease Models, Animal; Half-Life; Hypoxia; Liver Neoplasms, Experimental; Misonidazole; Monosaccharides; Nitroimidazoles; Peritoneal Neoplasms; Positron-Emission Tomography; Rats; Tissue Distribution | 2008 |
Correlation of [18F]FMISO autoradiography and pimonidazole [corrected] immunohistochemistry in human head and neck carcinoma xenografts.
Topics: Animals; Autoradiography; Biomarkers, Tumor; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Misonidazole; Nitroimidazoles; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity | 2008 |
Comparative pharmacokinetics, biodistribution, metabolism and hypoxia-dependent uptake of [18F]-EF3 and [18F]-MISO in rodent tumor models.
Topics: Animals; Fluorine Radioisotopes; Hypoxia; Male; Mice; Mice, Inbred C3H; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiopharmaceuticals; Tissue Distribution | 2008 |
[18F]EF3 is not superior to [18F]FMISO for PET-based hypoxia evaluation as measured in a rat rhabdomyosarcoma tumour model.
Topics: Animals; Autoradiography; Biomarkers; Heart; Hypoxia; Male; Misonidazole; Myocardium; Nitroimidazoles; Positron-Emission Tomography; Rats; Reference Values; Rhabdomyosarcoma; Tissue Distribution | 2009 |
Noninvasive molecular imaging of hypoxia in human xenografts: comparing hypoxia-induced gene expression with endogenous and exogenous hypoxia markers.
Topics: Animals; Antigens, Neoplasm; Arabinofuranosyluracil; Autoradiography; Biomarkers; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Etanidazole; Female; Gene Expression; Green Fluorescent Proteins; Herpesvirus 1, Human; HT29 Cells; Humans; Hydrocarbons, Fluorinated; Immunohistochemistry; Mice; Mice, Nude; Misonidazole; Neoplasm Transplantation; Neoplasms; Nitroimidazoles; Positron-Emission Tomography; Thymidine Kinase; Tissue Distribution; Transplantation, Heterologous | 2008 |
Noninvasive multimodality imaging of the tumor microenvironment: registered dynamic magnetic resonance imaging and positron emission tomography studies of a preclinical tumor model of tumor hypoxia.
Topics: Animals; Autoradiography; Cell Hypoxia; Disease Models, Animal; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Rats | 2009 |
Design, synthesis, and preliminary biological evaluation of 6-O-glucose-azomycin adducts for diagnosis and therapy of hypoxic tumors.
Topics: Cell Hypoxia; Cell Line, Tumor; Drug Design; Glucose Transport Proteins, Facilitative; Glucosides; Glycosides; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents; Radionuclide Imaging; Radiopharmaceuticals; Transcriptional Activation | 2012 |
Tumor microenvironment-dependent 18F-FDG, 18F-fluorothymidine, and 18F-misonidazole uptake: a pilot study in mouse models of human non-small cell lung cancer.
Topics: Animals; Biological Transport; Bromodeoxyuridine; Carcinoma, Non-Small-Cell Lung; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Dideoxynucleosides; Disease Models, Animal; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Lung Neoplasms; Mice; Misonidazole; Necrosis; Nitroimidazoles; Pilot Projects; Positron-Emission Tomography; Radioactive Tracers; Tumor Microenvironment | 2012 |
¹⁸F-HX4 hypoxia imaging with PET/CT in head and neck cancer: a comparison with ¹⁸F-FMISO.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Cell Hypoxia; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Middle Aged; Misonidazole; Multimodal Imaging; Nitroimidazoles; Positron-Emission Tomography; Tomography, X-Ray Computed; Triazoles | 2012 |
Biological characteristics of intratumoral [F-18]‑fluoromisonidazole distribution in a rodent model of glioma.
Topics: Animals; Autoradiography; Biological Transport; Brain Neoplasms; Cell Hypoxia; Cell Proliferation; Fluorodeoxyglucose F18; Glioma; Glucose; Glucose Transporter Type 1; Hexokinase; Hypoxia-Inducible Factor 1; Ki-67 Antigen; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Wistar; Tissue Distribution | 2013 |
Design and synthesis of 2-nitroimidazoles with variable alkylating and acylating functionality.
Topics: Acylation; Alkylating Agents; Animals; Drug Design; Drug Screening Assays, Antitumor; Mice; Misonidazole; Nitroimidazoles; Radiation-Sensitizing Agents; Structure-Activity Relationship | 2014 |
A comparative study of the hypoxia PET tracers [¹⁸F]HX4, [¹⁸F]FAZA, and [¹⁸F]FMISO in a preclinical tumor model.
Topics: Animals; Cell Hypoxia; Cell Line, Tumor; Computer Simulation; Imidazoles; Misonidazole; Models, Biological; Nitroimidazoles; Oxygen; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Reproducibility of Results; Rhabdomyosarcoma; Sensitivity and Specificity; Triazoles | 2015 |
The Effects of Pulsed Radiation Therapy on Tumor Oxygenation in 2 Murine Models of Head and Neck Squamous Cell Carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Coloring Agents; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Head and Neck Neoplasms; Heterografts; Mice; Mice, Nude; Misonidazole; Neoplasm Recurrence, Local; Nitroimidazoles; Oxygen Consumption; Positron-Emission Tomography; Radiopharmaceuticals; Squamous Cell Carcinoma of Head and Neck; Tumor Burden | 2015 |
Comparison of [18F]-FMISO, [18F]-FAZA and [18F]-HX4 for PET imaging of hypoxia--a simulation study.
Topics: Humans; Hypoxia; Imidazoles; Misonidazole; Models, Theoretical; Nitroimidazoles; Positron-Emission Tomography; Radiopharmaceuticals; Triazoles | 2015 |
Correlation of FMISO simulations with pimonidazole-stained tumor xenografts: A question of O2 consumption?
Topics: Animals; Benzimidazoles; Carcinoma, Squamous Cell; Cell Line, Tumor; Computer Simulation; Feasibility Studies; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Hypoxia; Mice, Nude; Misonidazole; Models, Biological; Neoplasm Transplantation; Nitroimidazoles; Oxygen Consumption; Platelet Endothelial Cell Adhesion Molecule-1; Tumor Microenvironment | 2016 |
Quantitative [
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mammary Neoplasms, Animal; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Receptor, ErbB-2; Trastuzumab; Tumor Burden; Tumor Hypoxia | 2017 |
Comparative evaluation of [
Topics: Animals; Autoradiography; Cell Line, Tumor; Fluorine Radioisotopes; Mice; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Radiochemistry; Reference Standards; Tissue Distribution; Tumor Hypoxia | 2019 |
Targeting Hypoxia Using Evofosfamide and Companion Hypoxia Imaging of FMISO-PET in Advanced Biliary Tract Cancer.
Topics: Biliary Tract Neoplasms; Cell Hypoxia; Female; Humans; Male; Middle Aged; Misonidazole; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Prospective Studies | 2021 |
Correlation of Tumor Hypoxia Metrics Derived from
Topics: Animals; Benchmarking; Brain; Fluorescence; Misonidazole; Nitroimidazoles; Positron-Emission Tomography; Rats; Tumor Hypoxia | 2020 |
Topics: Cell Hypoxia; CTLA-4 Antigen; Humans; Hypoxia; Misonidazole; Neoplasms; Nitroimidazoles; Phosphoramide Mustards; Positron-Emission Tomography; Programmed Cell Death 1 Receptor; Tumor Microenvironment | 2022 |