azomycin has been researched along with lomustine in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (86.84) | 18.7374 |
| 1990's | 5 (13.16) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bloomer, WD; Mainwaring, A; Papadopoulou, MV | 1 |
| Wallen, CA; Wheeler, KT; Wong, KH | 2 |
| Bleehen, NM; Freedman, LS; Stenning, SP | 1 |
| Ganz, JC; Hagen, S; Hatlevoll, R; Kristiansen, K; Lindegaard, KF; Mella, O; Nesbakken, R; Ringkjöb, R; Rosengren, B; Torvik, A | 1 |
| Cheeseman, KH; Lee, FY; Workman, P | 1 |
| Workman, P | 1 |
| Lee, FY; Workman, P | 5 |
| Bleehen, NM; Newman, HF; Roberts, JT | 1 |
| Mulcahy, RT; Siemann, DW | 2 |
| Lee, FY; Walton, MI; Workman, P | 1 |
| Hill, SA; Keng, PC; Maddison, K; Siemann, DW; Wolf, K | 1 |
| Bleehen, NM; Roberts, JT | 1 |
| Mulcahy, RT | 2 |
| Kehrberg, G; Moldenhauer, H; Rose, H; Saul, G; Wolf, G | 1 |
| Adams, GE | 1 |
| Siemann, DW | 5 |
| Hill, SA; Keng, PC; Siemann, DW | 1 |
| Bauer, KD; Hill, SA; Keng, PC; Siemann, DW | 1 |
| Hill, SA; Siemann, DW | 1 |
| Bleehen, NM; Lee, FY; Roberts, JT; Walton, MI; Workman, P | 1 |
| Brown, JM; Hazlehurst, JL; Hirst, DG | 2 |
| Siemann, DW; Wallen, CA; Wheeler, KT; Wolf, KL | 1 |
| Morrissey, S; Siemann, DW; Wolf, K | 1 |
| Twentyman, PR; Workman, P | 2 |
| Twentyman, P; Workman, P | 1 |
2 review(s) available for azomycin and lomustine
| Article | Year |
|---|---|
[Intensification of cytostatic action by radiosensitizers--a review of the present status of chemosensitization].
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Chlorambucil; Cisplatin; Cricetinae; Cyclophosphamide; Doxorubicin; Etanidazole; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents | 1984 |
Modification of chemotherapy by nitroimidazoles.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; DNA Repair; Drug Synergism; Glutathione; Lomustine; Melphalan; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Oxygen; Radiation-Sensitizing Agents; Time Factors | 1984 |
3 trial(s) available for azomycin and lomustine
| Article | Year |
|---|---|
A randomized study of CCNU with and without benznidazole in the treatment of recurrent grades 3 and 4 astrocytoma. Report to the Medical Research Council by the Brain Tumor Working Party.
Topics: Adolescent; Adult; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Double-Blind Method; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local; Nitroimidazoles; Prognosis; Random Allocation | 1989 |
Combined modality treatment of operated astrocytomas grade 3 and 4. A prospective and randomized study of misonidazole and radiotherapy with two different radiation schedules and subsequent CCNU chemotherapy. Stage II of a prospective multicenter trial of
Topics: Actuarial Analysis; Adult; Aged; Brain Neoplasms; Clinical Trials as Topic; Combined Modality Therapy; Female; Glioblastoma; Humans; Lomustine; Male; Middle Aged; Misonidazole; Nitroimidazoles; Radiotherapy Dosage; Random Allocation; Scandinavian and Nordic Countries; Telencephalon | 1985 |
Benznidazole with CCNU: a clinical phase I toxicity study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Brain Neoplasms; Drug Evaluation; Humans; Lomustine; Nitroimidazoles | 1985 |
33 other study(ies) available for azomycin and lomustine
| Article | Year |
|---|---|
Potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea's toxicity in vitro by two new bioreductive agents.
Topics: Aminoacridines; Animals; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Drug Synergism; Kinetics; Lomustine; Mathematics; Nitroimidazoles; Radiation-Sensitizing Agents | 1992 |
2-Nitroimidazole potentiation of nitrosourea induced cytotoxicity in subcutaneous implants of rat 9L brain tumor cells.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Carmustine; Cell Line; Cell Survival; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Nitroimidazoles; Rats; Rats, Inbred F344; Streptozocin; Tumor Stem Cell Assay | 1991 |
Chemosensitization of the nitrosoureas by 2-nitroimidazoles in the subcutaneous 9L tumor model: pharmacokinetic and structure-activity considerations.
Topics: Animals; Carmustine; Drug Synergism; Etanidazole; Lomustine; Male; Misonidazole; Neoplasm Transplantation; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Rats; Rats, Inbred F344; Structure-Activity Relationship | 1990 |
Misonidazole and benznidazole inhibit hydroxylation of CCNU by mouse liver microsomal cytochrome P-450 in vitro.
Topics: Animals; Cytochrome P-450 Enzyme System; Hydroxylation; In Vitro Techniques; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Microsomes, Liver; Misonidazole; Nitroimidazoles; Structure-Activity Relationship | 1987 |
Chemosensitization of lomustine by misonidazole, benznidazole, and RSU 1069.
Topics: Animals; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1986 |
Interaction of nitroimidazole sensitizers with drug metabolizing enzymes--spectral and kinetic studies.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; In Vitro Techniques; Lomustine; Mice; Microsomes, Liver; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
A phase II study of CCNU with benznidazole for metastatic malignant melanoma.
Topics: Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Lomustine; Melanoma; Nitroimidazoles | 1986 |
Sensitization of cancer chemotherapeutic agents by nitroheterocyclics.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cell Survival; Drug Synergism; Heterocyclic Compounds; Hydroxamic Acids; Hypoxia; Lomustine; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Radiation-Sensitizing Agents | 1986 |
Benznidazole: nitroreduction and inhibition of cytochrome P-450 in chemosensitization of tumour response to cytotoxic drugs.
Topics: Animals; Cell Survival; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Synergism; Kinetics; Lomustine; Mice; Microsomes, Liver; Misonidazole; Nitroimidazoles; Oxidation-Reduction | 1986 |
In vivo interaction between radiation and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea in the absence or presence of misonidazole in mice.
Topics: Animals; Combined Modality Therapy; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Tumor Stem Cell Assay | 1985 |
Misonidazole protects mouse tumour and normal tissues from the toxicity of oral CCNU.
Topics: Administration, Oral; Animals; Drug Interactions; Fibrosarcoma; Injections, Intraperitoneal; Lethal Dose 50; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles | 1985 |
Chemopotentiation of CCNU metabolites by misonidazole.
Topics: Animals; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles | 1985 |
Radiosensitizers: a conference preview.
Topics: Animals; Aziridines; Buthionine Sulfoximine; Carmustine; Combined Modality Therapy; Drug Synergism; Etanidazole; Humans; Ketones; Lomustine; Maleates; Methionine Sulfoximine; Mice; Misonidazole; Neoplasms; Nitroimidazoles; Radiation-Sensitizing Agents | 1984 |
Nitroimidazoles as modifiers of nitrosourea pharmacokinetics.
Topics: Animals; Antineoplastic Agents; Carmustine; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Semustine; Streptozocin; Time Factors | 1984 |
Response of murine tumours to combinations of CCNU with misonidazole and other radiation sensitizers.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etanidazole; Female; Leukocyte Count; Lomustine; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1982 |
Effect of oxygen on misonidazole chemosensitization and cytotoxicity in vitro.
Topics: Aerobiosis; Animals; Cell Line; Cell Survival; Kinetics; Lomustine; Mammary Neoplasms, Experimental; Mice; Misonidazole; Nitroimidazoles; Oxygen | 1984 |
Survival in subpopulations of cells derived from solid KHT sarcomas by centrifugal elutriation following treatment with CCNU and MISO.
Topics: Animals; Cell Cycle; Cell Separation; Cell Survival; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental | 1984 |
The effect in the KHT sarcoma of CCNU and MISO on cell cycle progression evaluated by flow-cytometry.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Drug Synergism; Drug Therapy, Combination; Flow Cytometry; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; RNA, Neoplasm; Sarcoma, Experimental | 1984 |
Enhanced tumor responses through therapies combining CCNU, MISO and radiation.
Topics: Animals; Combined Modality Therapy; Drug Synergism; Drug Therapy, Combination; Female; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Neoplasm Transplantation; Nitroimidazoles; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1984 |
A phase I study of the combination of benznidazole and CCNU in man.
Topics: Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Humans; Lomustine; Neoplasms; Nitroimidazoles; Trypanocidal Agents | 1984 |
Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Hematopoietic Stem Cells; Injections, Intraperitoneal; Lomustine; Male; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Solubility; Spermatogonia | 1983 |
Misonidazole and CCNU: further evidence for a pharmacokinetic mechanism of chemosensitization and therapeutic gain.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Intestine, Small; Kinetics; Lomustine; Male; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1984 |
Hypoxic cells and in situ chemopotentiation of the nitrosoureas by misonidazole.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Misonidazole; Nitroimidazoles; Oxygen; Rats; Skin Neoplasms; Tumor Stem Cell Assay | 1984 |
In vivo potentiation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea by the radiation sensitizer benznidazole.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Radiation-Sensitizing Agents; Sarcoma, Experimental; Time Factors | 1983 |
Modification of CCNU pharmacokinetics by misonidazole--a major mechanism of chemosensitization in mice.
Topics: Animals; Blood Proteins; Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Female; Half-Life; Kinetics; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds | 1983 |
Chemosensitization by lipophilic nitroimidazoles.
Topics: Animals; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Leukocyte Count; Lomustine; Male; Melphalan; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental; Time Factors | 1983 |
In vivo chemosensitization by misonidazole in sensitive and resistant tumor lines.
Topics: Animals; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Humans; Leukemia L1210; Lomustine; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental | 1983 |
Effect of misonidazole or metronidazole pretreatment on the response of the RIF-1 mouse sarcoma to melphalan, cyclophosphamide, chlorambucil and CCNU.
Topics: Animals; Antineoplastic Agents; Cell Survival; Chlorambucil; Cyclophosphamide; Drug Synergism; Drug Therapy, Combination; Female; Lethal Dose 50; Leukocyte Count; Lomustine; Male; Melphalan; Metronidazole; Mice; Mice, Inbred C3H; Misonidazole; Nitroimidazoles; Sarcoma, Experimental | 1982 |
Structure/activity relationships for the enhancement by electron-affinic drugs of the anti-tumour effect of CCNU.
Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Lomustine; Mice; Mice, Inbred C3H; Nitroimidazoles; Nitrosourea Compounds; Oxidation-Reduction; Sarcoma, Experimental; Solubility; Structure-Activity Relationship | 1982 |
Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Hematopoietic Stem Cells; Lomustine; Male; Mice; Mice, Inbred Strains; Misonidazole; Neoplasms, Experimental; Nitroimidazoles; Nitrosourea Compounds; Spermatogonia; Time Factors | 1982 |
In vivo combination of misonidazole and the chemotherapeutic agent CCNU.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Lomustine; Mice; Misonidazole; Nitroimidazoles; Nitrosourea Compounds; Sarcoma, Experimental; Time Factors | 1981 |
Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872.
Topics: Animals; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Lomustine; Mice; Nitroimidazoles; Prodrugs; Sarcoma, Experimental; Stereoisomerism; Tumor Cells, Cultured | 1995 |
In vitro cytotoxicity and chemosensitizing activity of the dual function nitroimidazole RB 6145.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Humans; Lomustine; Mice; Nitroimidazoles; Prodrugs; Stereoisomerism; Tumor Cells, Cultured | 1994 |