Page last updated: 2024-08-21

azomycin and fexinidazole

azomycin has been researched along with fexinidazole in 48 studies

Research

Studies (48)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (4.17)	18.7374
1990's	4 (8.33)	18.2507
2000's	0 (0.00)	29.6817
2010's	31 (64.58)	24.3611
2020's	11 (22.92)	2.80

Authors

Authors	Studies
Jennings, FW	1
Raether, W; Seidenath, H	1
Jennings, FW; Urquhart, GM	1
Atouguia, JM; Jennings, FW; Murray, M	1
Moreno, SN; Yan, W	1
Bouteille, B; Chauviere, G	1
Barrett, MP	1
Bourdin Trunz, B; Bray, MA; Brun, R; Kaiser, M; Mazué, G; Pécoul, B; Torreele, E; Tweats, D	1
Bot, C; Hall, BS; Kelly, JM; Wilkinson, SR	1
Barrett, MP; Brun, R; Don, R; Jacobs, RT; Wang, MZ	1
Bourdin Trunz, B; Bray, MA; Brun, R; Cal, M; Kaiser, M; Torreele, E	1
Fairlamb, AH; Kime, R; Norval, S; Patterson, S; Read, KD; Simeons, FR; Stojanovski, L; Wyllie, S	1
Bourdin Trunz, B; Torreele, E; Tweats, D	1
Bahia, MT; Caldas, IS; de Andrade, IM; Diniz, Lde F; do Nascimento, ÁF; Martins, TA; Ribeiro, I; Talvani, A; Torreele, E; Trunz, BB	1
Barrett, MP; Croft, SL	1
Fairlamb, AH; Patterson, S; Wyllie, S	1
De Rycker, M; Fairlamb, AH; Norval, S; Osuna-Cabello, M; Patterson, S; Perry, MR; Read, KD; Simeons, FR; Stojanovski, L; Wyllie, S	1
Bucheton, B; Courtois, P; Cuny, G; Daulouède, S; Dethoua, M; Nzoumbou-Boko, R; Semballa, S; Truc, P; Vincendeau, P	1
Blesson, S; Bray, MA; Evène, E; Felices, M; Gualano, V; Hovsepian, L; Mordt, OV; Sassella, D; Strub-Wourgaft, N; Tarral, A; Torreele, E	1
Bahia, MT; Caldas, IS; Charman, SA; Chatelain, E; Diniz, Lde F; Gonçalves, KR; Koltun, M; Marques, LF; Mazzeti, AL; Mota, LW; Nascimento, AF; Saunders, J; Scandale, I; Shackleford, DM; Talvani, A; White, KL	1
Ardiot, C; Blesson, S; Bompart, F; Bonnin, Y; Coleman, CH; Colonna, P; Dhai, A; Ecuru, J; Edielu, A; Hervé, C; Hirsch, F; Kouyaté, B; Mamzer-Bruneel, MF; Maoundé, D; Martinent, E; Ntsiba, H; Pelé, G; Quéva, G; Reinmund, MC; Sarr, SC; Sepou, A; Strub-Wourgaft, N; Tarral, A; Tetimian, D; Valverde, O; Van Nieuwenhove, S	1
Berriman, M; Fairlamb, AH; Foth, BJ; Kelner, A; Sokolova, AY; Wyllie, S	1
Maxmen, A	2
Abgrall, A; Augé, C; Blesson, S; Filali-Ansary, A; Mordt, OV; Pellissier, F; Sanderink, GJ; Souchaud, M	1
Charman, SA; Chatelain, E; Chen, G; Francisco, AF; Jayawardhana, S; Kelly, JM; Lewis, MD; Osuna-Cabello, M; Read, KD; Saunders, J; Shackleford, DM; White, KL	1
Koniordou, M; Patterson, S; Seifert, K; Wyllie, S	1
Alavijeh, MS; Burrell-Saward, H; Croft, SL; de LaFlor, R; Harris, AJ; Sallam, H; Ward, TH	1
Badibabi, LK; Bardonneau, C; Bernhard, S; Blesson, S; Bonama, AK; Dama, FR; Delhomme, S; Heradi, JA; Ilunga, M; Kalonji, WM; Kuziena, W; Lubaki, JF; Lukula, PK; Lumbala, C; Mandula, G; Mbembo, HM; Mesu, VKBK; Mordt, OV; Ngima, PN; Scherrer, B; Simon, F; Solomo, JLL; Strub-Wourgaft, N; Tarral, A; Tete, DN; Vuvu, SL	1
Pollastri, MP	1
Chappuis, F	1
Deeks, ED	1
Aguiar, MMG; de Morais-Teixeira, E; Rabello, A	1
Cavaleri, M; Harvey Allchurch, M; Nagercoil, N; Nambasa, V; Ntamabyaliro, N; Pelfrene, E; Ventura, FV	1
Burki, T	1
Bayão, TS; Cupertino, MDC; Gomes, AP; Siqueira-Batista, R	1
Fairlamb, AH	1
Akl, EA; Barrett, MP; Bergman, H; Chappuis, F; Erphas, O; Franco, JR; Kadima Ebeja, A; Kazumba, L; Lejon, V; Lindner, AK; Mwamba, E; Priotto, G; Seixas, J; Simarro, P; Villanueva, G	1
Kaiser, M; Mäser, P	1
Akwaso Masa, F; Bardonneau, C; Bernhard, S; Blesson, S; Botalema Bolengi, F; Delhomme, S; Kande Betu Ku Mesu, V; Kapongo Tshilumbwa, S; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mayala Malu, T; Mpia Moke, C; Mpoyi Muamba Nzambi, D; Mudji E'kitiak, J; Mukendi Ilunga, M; Mutombo Kalonji, W; Ngolo Tete, D; Nkieri Matsho, M; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O	1
Bahia, MT; Diniz, LF; Gonçalves, KR; Mazzeti, AL; Mota, SLA; Pereira, DE	1
Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O	1
Barreira, F; Bilbe, G; Blum, B; Gascón, J; Ortiz, L; Palacios, A; Pinazo, MJ; Pinto, J; Ribeiro, I; Rojas, G; Schijman, AG; Strub-Wourgaft, N; Torrico, F; Vaillant, M	1
Bardonneau, C; Bernhard, S; Blesson, S; Delhomme, S; Fina Lubaki, JP; Ilunga Wa Kyhi, M; Kande Betu Kumesu, V; Kaninda Badibabi, L; Kasongo Bonama, A; Kavunga Lukula, P; Kuziena Mindele, W; Lumbala, C; Lumeya Vuvu, S; Mahenzi Mbembo, H; Mandula Mokenge, G; Mutombo Kalonji, W; Nganzobo Ngima, P; Ngolo Tete, D; Scherrer, B; Simon, F; Strub-Wourgaft, N; Tarral, A; Valverde Mordt, O	1
de Souza, W; Zuma, AA	1
Aguiar, MG; Antunes, PA; Cardoso, VN; Damasio, DSDN; Fernandes, SOA; Ferreira, LAM; Lages, EB; Morais-Teixeira, E; Vital, KD	1
Gudmundsson, KSS; Helleberg, BB; Helleberg, M; Kurtzhals, JAL	1

Reviews

7 review(s) available for azomycin and fexinidazole

Article	Year
[Use of megazol for the treatment of trypanosomiasis]. Medecine tropicale : revue du Corps de sante colonial, 1999, Volume: 59, Issue:4 Topics: Acetanilides; Animals; Anti-Infective Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Metronidazole; Mice; Nitroimidazoles; Thiadiazoles; Trypanocidal Agents; Trypanosomiasis	1999
Potential new drugs for human African trypanosomiasis: some progress at last. Current opinion in infectious diseases, 2010, Volume: 23, Issue:6 Topics: Animals; Benzamides; Boron Compounds; Drug Discovery; Drug Resistance; Drug Therapy, Combination; Eflornithine; Humans; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2010
Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives. Current topics in medicinal chemistry, 2011, Volume: 11, Issue:16 Topics: Africa; Animals; Benzamides; Chagas Disease; Humans; Insect Vectors; Latin America; Nifurtimox; Nitro Compounds; Nitroimidazoles; Nitroreductases; Phosphoramide Mustards; Prodrugs; Protozoan Proteins; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomiasis, African	2011
Development of novel drugs for human African trypanosomiasis. Future microbiology, 2011, Volume: 6, Issue:6 Topics: Animals; Antiprotozoal Agents; Benzoxazoles; Clinical Trials as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Haplorhini; Humans; Mice; Neglected Diseases; Nitroimidazoles; Trypanosoma brucei brucei; Trypanosomiasis, African	2011
Management of trypanosomiasis and leishmaniasis. British medical bulletin, 2012, Volume: 104 Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Chagas Disease; Drug Therapy, Combination; Humans; India; Leishmaniasis; Nitroimidazoles; Pentamidine; Triazoles; Trypanosomiasis, African	2012
Fexinidazole: First Global Approval. Drugs, 2019, Volume: 79, Issue:2 Topics: Administration, Oral; Drug Approval; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2019
Fexinidazole for the treatment of human African trypanosomiasis. Drugs of today (Barcelona, Spain : 1998), 2019, Volume: 55, Issue:11 Topics: Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African	2019

Trials

4 trial(s) available for azomycin and fexinidazole

Article	Year
Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies. Clinical pharmacokinetics, 2014, Volume: 53, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Cross-Over Studies; Dietary Fats; Dose-Response Relationship, Drug; Double-Blind Method; Food-Drug Interactions; Humans; Male; Middle Aged; Nitroimidazoles; Prodrugs; Suspensions; Tablets; Trypanocidal Agents; Trypanosomiasis, African; Young Adult	2014
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial. Lancet (London, England), 2018, 01-13, Volume: 391, Issue:10116 Topics: Administration, Oral; Adult; Democratic Republic of the Congo; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2018
A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023, 02-08, Volume: 76, Issue:3 Topics: Adult; Chagas Disease; Double-Blind Method; Humans; Neutropenia; Nitroimidazoles; Treatment Outcome	2023
Safety and efficacy of oral fexinidazole in children with gambiense human African trypanosomiasis: a multicentre, single-arm, open-label, phase 2-3 trial. The Lancet. Global health, 2022, Volume: 10, Issue:11 Topics: Administration, Oral; Child; Humans; Nitroimidazoles; Tablets; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2022

Other Studies

37 other study(ies) available for azomycin and fexinidazole

Article	Year
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds. Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:2 Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1991
The activity of fexinidazole (HOE 239) against experimental infections with Trypanosoma cruzi, trichomonads and Entamoeba histolytica. Annals of tropical medicine and parasitology, 1983, Volume: 77, Issue:1 Topics: Animals; Antiprotozoal Agents; Chagas Disease; Cricetinae; Dogs; Entamoebiasis; Female; Guinea Pigs; Macaca; Male; Mesocricetus; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Nitroimidazoles; Protozoan Infections; Rabbits; Rats; Trichomonas Infections; Tritrichomonas	1983
The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1983, Volume: 69, Issue:5 Topics: Animals; Antiprotozoal Agents; Chronic Disease; Diminazene; Drug Therapy, Combination; Female; Mice; Mice, Inbred Strains; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1983
Topical chemotherapy for experimental murine African CNS-trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5-nitroimidazoles, fexinidazole or MK-436. Tropical medicine & international health : TM & IH, 1996, Volume: 1, Issue:5 Topics: Administration, Topical; Animals; Antiprotozoal Agents; Dose-Response Relationship, Drug; Drug Combinations; Female; Gels; Melarsoprol; Mice; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African	1996
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation. Journal of immunological methods, 1998, Nov-01, Volume: 220, Issue:1-2 Topics: Animals; Cells, Cultured; DNA Replication; DNA, Protozoan; Drug Evaluation, Preclinical; Drug Resistance; Gamma Rays; Muscle, Skeletal; Nifurtimox; Nitroimidazoles; Rats; Reproduction; Thiadiazoles; Trypanocidal Agents; Trypanosoma cruzi; Uracil	1998
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS neglected tropical diseases, 2010, Dec-21, Volume: 4, Issue:12 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Dogs; Female; Inhibitory Concentration 50; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Rats; Treatment Outcome; Trypanosomiasis, African	2010
Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness. Antimicrobial agents and chemotherapy, 2011, Volume: 55, Issue:12 Topics: Animals; Female; Humans; Mice; Nitroimidazoles; Parasitic Sensitivity Tests; Safrole; Sulfones; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2011
The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis. Science translational medicine, 2012, Feb-01, Volume: 4, Issue:119 Topics: Administration, Oral; Animals; Biotransformation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Leishmania donovani; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Protozoan Proteins; Sulfones; Sulfoxides; Trypanocidal Agents	2012
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness). Mutagenesis, 2012, Volume: 27, Issue:5 Topics: Animals; Bacteria; Bone Marrow Cells; Hepatocytes; Humans; Leukocytes, Mononuclear; Male; Mice; Micronucleus Tests; Mutagenicity Tests; Mutagens; Nitroimidazoles; Nitroreductases; Rats; Trypanocidal Agents; Trypanosomiasis, African	2012
Fexinidazole: a potential new drug candidate for Chagas disease. PLoS neglected tropical diseases, 2012, Volume: 6, Issue:11 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Mice; Nitroimidazoles; Parasitemia; Survival Analysis; Treatment Outcome; Trypanosoma cruzi	2012
Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:2 Topics: Cell Line; Drug Resistance; Gene Knockout Techniques; Leishmania donovani; Leishmaniasis, Visceral; Nitro Compounds; Nitroimidazoles; Nitroreductases; Trypanocidal Agents	2013
The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:10 Topics: Animals; Antiprotozoal Agents; Antitubercular Agents; Female; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Nitroimidazoles; Stereoisomerism	2013
Evaluation of trypanocidal drugs used for human African trypanosomosis against Trypanosoma lewisi. Parasite (Paris, France), 2013, Volume: 20 Topics: Animals; Eflornithine; Female; Humans; Immunocompromised Host; Inhibitory Concentration 50; Melarsoprol; Mice; Nifurtimox; Nitroimidazoles; Parasitemia; Pentamidine; Rats; Rats, Wistar; Suramin; Trypanocidal Agents; Trypanosoma lewisi; Trypanosomiasis	2013
Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:8 Topics: Administration, Oral; Animals; Biotransformation; Chagas Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Mice; Nitroimidazoles; Sulfones; Sulfoxides; Survival Analysis; Trypanocidal Agents; Trypanosoma cruzi	2014
Improving the Quality of Host Country Ethical Oversight of International Research: The Use of a Collaborative 'Pre-Review' Mechanism for a Study of Fexinidazole for Human African Trypanosomiasis. Developing world bioethics, 2015, Volume: 15, Issue:3 Topics: Antiprotozoal Agents; Biomedical Research; Developing Countries; Ethical Review; Humans; International Cooperation; Nitroimidazoles; Trypanosomiasis, African	2015
Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei. The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:3 Topics: Antiprotozoal Agents; Drug Resistance; Genome, Protozoan; Nifurtimox; Nitroimidazoles; Nitroreductases; Parasitic Sensitivity Tests; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Trypanosoma brucei brucei	2016
Busting the billion-dollar myth: how to slash the cost of drug development. Nature, 2016, 08-25, Volume: 536, Issue:7617 Topics: Africa; Amodiaquine; Anti-Bacterial Agents; Artemisinins; Benzamides; Boron Compounds; Child; Clinical Trials as Topic; Cooperative Behavior; Developed Countries; Developing Countries; Drug Approval; Drug Combinations; Drug Costs; Drug Discovery; Drug Industry; Drug Repositioning; Drug Resistance, Microbial; Female; Humans; Malaria; Neglected Diseases; Negotiating; Nitroimidazoles; Organizations, Nonprofit; Sample Size; Trypanosomiasis, African; World Health Organization	2016
A DBS method for quantitation of the new oral trypanocidal drug fexinidazole and its active metabolites. Bioanalysis, 2016, Volume: 8, Issue:19 Topics: Administration, Oral; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Hematocrit; Hemolysis; Humans; Linear Models; Nitroimidazoles; Quality Control; Tandem Mass Spectrometry; Temperature; Time Factors; Trypanocidal Agents	2016
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage. Scientific reports, 2016, 10-17, Volume: 6 Topics: Animals; Area Under Curve; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Nifurtimox; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosoma cruzi	2016
Snapshot Profiling of the Antileishmanial Potency of Lead Compounds and Drug Candidates against Intracellular Leishmania donovani Amastigotes, with a Focus on Human-Derived Host Cells. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3 Topics: Animals; Antimony; Antiprotozoal Agents; Cell Differentiation; Cell Line; Host-Pathogen Interactions; Humans; Inhibitory Concentration 50; Leishmania donovani; Macrophages; Mice; Mice, Knockout; Monocytes; Nitroimidazoles; Primary Cell Culture; Stereoisomerism; Tetradecanoylphorbol Acetate	2017
Dose-dependent effect and pharmacokinetics of fexinidazole and its metabolites in a mouse model of human African trypanosomiasis. International journal of antimicrobial agents, 2017, Volume: 50, Issue:2 Topics: Animals; Antiprotozoal Agents; Cerebral Cortex; Cerebrospinal Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Luminescent Measurements; Mice; Nitroimidazoles; Plasma; Treatment Outcome; Trypanosoma; Trypanosomiasis, African; Whole Body Imaging	2017
Sleeping sickness can now be cured with pills. Nature, 2017, 10-18, Volume: 550, Issue:7677 Topics: Administration, Oral; Clinical Trials, Phase III as Topic; Drug Approval; Drug Combinations; Humans; Nitroimidazoles; Trypanosomiasis, African	2017
Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon. Trends in parasitology, 2018, Volume: 34, Issue:3 Topics: Clinical Trials as Topic; Drug Approval; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African	2018
Oral fexinidazole for human African trypanosomiasis. Lancet (London, England), 2018, 01-13, Volume: 391, Issue:10116 Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosomiasis, African	2018
In vitro activity and in vivo efficacy of fexinidazole against New World Leishmania species. The Journal of antimicrobial chemotherapy, 2019, 08-01, Volume: 74, Issue:8 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Female; Leishmania; Leishmaniasis; Male; Mesocricetus; Mice, Inbred BALB C; Nitroimidazoles	2019
The European Medicines Agency's scientific opinion on oral fexinidazole for human African trypanosomiasis. PLoS neglected tropical diseases, 2019, Volume: 13, Issue:6 Topics: Administration, Oral; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Humans; Nitroimidazoles; Treatment Outcome; Trypanocidal Agents; Trypanosomiasis, African	2019
Recognition for Chagas disease. The Lancet. Infectious diseases, 2019, Volume: 19, Issue:7 Topics: Chagas Disease; Humans; Latin America; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi	2019
Fexinidazole and Human African Trypanosomiasis: good news for this important neglected tropical disease. Revista da Sociedade Brasileira de Medicina Tropical, 2019, Volume: 52 Topics: Humans; Neglected Diseases; Nitroimidazoles; Trypanocidal Agents; Trypanosomiasis, African	2019
New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice. The Lancet. Infectious diseases, 2020, Volume: 20, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiprotozoal Agents; Child; Child, Preschool; Eflornithine; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Nifurtimox; Nitroimidazoles; Practice Guidelines as Topic; Trypanosoma brucei gambiense; Trypanosomiasis, African; World Health Organization; Young Adult	2020
In Vitro Drug Efficacy Testing Against Trypanosoma brucei. Methods in molecular biology (Clifton, N.J.), 2020, Volume: 2116 Topics: Calorimetry; Drug Evaluation, Preclinical; Humans; Life Cycle Stages; Nitroimidazoles; Parasitic Sensitivity Tests; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	2020
Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study. The Lancet. Global health, 2021, Volume: 9, Issue:7 Topics: Administration, Oral; Adolescent; Adult; Aged; Democratic Republic of the Congo; Female; Humans; Male; Middle Aged; Nitroimidazoles; Prospective Studies; Severity of Illness Index; Treatment Outcome; Trypanosoma brucei gambiense; Trypanosomiasis, African; Young Adult	2021
Combination therapy using nitro compounds improves the efficacy of experimental Chagas disease treatment. Parasitology, 2021, Volume: 148, Issue:11 Topics: Animals; Chagas Disease; Drug Therapy, Combination; Female; Humans; Inhibitory Concentration 50; Mice; Neglected Diseases; Nifurtimox; Nitro Compounds; Nitroimidazoles; Real-Time Polymerase Chain Reaction; Sulfones	2021
Fexinidazole. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2021, 11-09, Volume: 78, Issue:22 Topics: Administration, Oral; Humans; Nitroimidazoles; Trypanocidal Agents	2021
Development and Introduction of Fexinidazole into the Global Human African Trypanosomiasis Program. The American journal of tropical medicine and hygiene, 2022, 05-11, Volume: 106, Issue:5_Suppl Topics: Administration, Oral; Animals; Humans; Nitroimidazoles; Trypanosoma brucei gambiense; Trypanosomiasis, African	2022
Fexinidazole interferes with the growth and structural organization of Trypanosoma cruzi. Scientific reports, 2022, 11-27, Volume: 12, Issue:1 Topics: Chagas Disease; Humans; Morphogenesis; Nitroimidazoles; Trypanosoma cruzi	2022
A new oral self-emulsifying drug delivery system improves the antileishmania efficacy of fexinidazole in vivo. International journal of pharmaceutics, 2023, Jan-25, Volume: 631 Topics: Administration, Oral; Animals; Antiprotozoal Agents; Drug Delivery Systems; Emulsifying Agents; Emulsions; Nitroimidazoles; Solubility	2023
Second stage human African Trypanosomiasis with Trypanosoma brucei rhodesiense treated with fexinidazole. The Lancet. Infectious diseases, 2023, Volume: 23, Issue:11 Topics: Animals; Humans; Nitroimidazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	2023