azidopine has been researched along with rubrofusarin* in 1 studies
1 other study(ies) available for azidopine and rubrofusarin
Article | Year |
---|---|
Aspergillus species strain M39 produces two naphtho-gamma-pyrones that reverse drug resistance in human KB cells.
One thousand fungi and Actinomycetes were investigated to see whether they produced compounds that reverse multi-drug resistance in KB cells. Only one Aspergillus strain M39 produced agents with resistance-reversing activity and these compounds were identified to be rubrofusarin B and dianhydro-aurasperone C. Rubrofusarin B only slightly reversed the resistance of KB-C2 cells to Adriamycin and daunomycin, partially reversed the resistance to chromomycin A3, and almost completely reversed the resistance to vincristine and mitomycin C. Purified dianhydro-aurasperone C and rubrofusarin B had similar effects on drug resistance in KB-8-5 cells. Dianhydro-aurasperone C enhanced the accumulation of vinblastine in KB-8-5 cells and inhibited the efflux of vinblastine from the cells. Dianhydro-aurasperone C and rubrofusarin B at 10 microM completely inhibited 3H-azidopine photolabelling of P-glycoprotein. The two products of Aspergillus strain M39 appear to reverse multi-drug resistance by interacting with P-glycoprotein and inhibiting its role as an active efflux pump. Topics: Aspergillus; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Chemical Phenomena; Chemistry; Dihydropyridines; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Naphthols; Pyrans; Pyrones; Verapamil; Vinblastine | 1990 |