azides has been researched along with ro 15-4513 in 364 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 92 (25.27) | 18.7374 |
| 1990's | 179 (49.18) | 18.2507 |
| 2000's | 64 (17.58) | 29.6817 |
| 2010's | 27 (7.42) | 24.3611 |
| 2020's | 2 (0.55) | 2.80 |
| Authors | Studies |
|---|---|
| MacDonald, JF; Prasad, A; Reynolds, JN | 1 |
| Skolnick, P; Wong, G | 2 |
| Colker, RE; Domangue, KR; Hicks, LH; June, HL; June, PL; Lewis, MJ; Perry, LE | 1 |
| Korpi, ER; Uusi-Oukari, M; Wegelius, K | 1 |
| Uusi-Oukari, M | 3 |
| Casanova, M; Kleinman, JE; Korpi, ER; Uusi-Oukari, M; Wegelius, K; Zito, M | 1 |
| Korpi, ER; Uusi-Oukari, M | 2 |
| Gibert-Rahola, J; Maldonado, R; Micó, JA; Valverde, O | 1 |
| Hume, DA; Le, F; Shanley, BC; Wilce, PA | 1 |
| Farde, L; Hall, H; Halldin, C; Litton, JE; Sedvall, G | 1 |
| Jackson, HC; Nutt, DJ | 2 |
| Maksay, G | 1 |
| Sei, Y; Skolnick, P; Wong, G | 1 |
| Lüddens, H; Seeburg, PH; Wieland, HA | 1 |
| D'Amico, E; Koob, GF; Pulvirenti, L; Rassnick, S; Riley, E; Zieglgänsberger, W | 1 |
| Mehta, AK; Mhatre, M; Ticku, MK | 2 |
| Mhatre, MC; Ticku, MK | 2 |
| Dar, MS | 3 |
| Cunningham, CL; Malott, DH; Riley, AL; Risinger, FO | 1 |
| Inoue, O; Itoh, T; Kobayashi, K; Suhara, T; Suzuki, K; Tateno, Y | 2 |
| Domangue, KR; Hicks, LH; June, HL; June, PL; Lewis, MJ; Lummis, GH | 1 |
| Forster, MJ; Lal, H; Prather, PL | 1 |
| Egaña, E; Ramirez, MT; Salinas, A | 1 |
| Olsen, RW; Sapp, DW; Turner, DM | 1 |
| Lanoir, J; Pinard, R; Segu, L | 1 |
| Bosman, DK; Chamuleau, RA; de Haan, JG; Maas, MA; van den Buijs, CA | 1 |
| Bao, K; Becker, HC; Daniel, SS; Middaugh, LD | 1 |
| Herb, A; Keinänen, K; Lüddens, H; Seeburg, PH; Wieland, H; Wisden, W | 1 |
| Jones, EA | 1 |
| Druml, W; Ferenci, P; Püspök, A; Steindl, P | 1 |
| Bottlaender, M; Brouillet, E; Chavoix, C; Dodd, RH; Fournier, D; Hantraye, P; Khalili-Varasteh, M; Mazière, M | 1 |
| Chen, JP; Lal, H; Martin, MW; Prather, PL; Rezazadeh, SM | 1 |
| Binkley, P; Ticku, MK | 1 |
| Ewert, M; Kettenmann, H; Kleingoor, C; Seeburg, PH; von Blankenfeld, G | 1 |
| Inoue, O; Itoh, T; Långström, B; Suhara, T; Tsukada, H; Yamasaki, T; Yonezawa, H | 1 |
| Boix, F; Escorihuela, RM; Fernández-Teruel, A; Núñez, JF; Salazar, W; Tobeña, A; Zapata, A | 1 |
| Engel, JA; Söderpalm, B | 1 |
| Becker, HC; Hale, RL | 2 |
| Ticku, MK | 2 |
| Biggio, G; Concas, A; Sanna, E; Santoro, G; Serra, M | 1 |
| Carboni, G; Corda, MG; Frau, V; Giorgi, O; Lecca, D; Orlandi, M | 1 |
| Gent, JP; Goodchild, CS; Lowson, S | 1 |
| Colker, RE; June, HL; Lewis, MJ; Lummis, GH; Moore, TO | 1 |
| Kunos, G; Varga, K | 1 |
| Budhram, P; Deacon, RM; Gardner, CR; Thomson, TA | 1 |
| Coop, CF; Laverty, R; McNaughton, N; Warnock, K | 1 |
| Koob, GF; Schreiber, JF; Weinger, MB | 1 |
| Wettstein, JG | 1 |
| Basile, AS; Gammal, SH; Geller, D; Jones, EA; Skolnick, P | 1 |
| Buck, KJ; Harris, RA | 1 |
| Collins, MD; Scott, WJ; Zimmerman, EF | 1 |
| Alkana, RL; Finn, DA; Jones, BL; Kobayashi, LS; Syapin, PJ | 1 |
| Borden, LA; Gibbs, TT | 1 |
| Chaplin, RI; Ehlers, CL; Koob, GF | 1 |
| Keinänen, K; Killisch, I; Köhler, M; Lüddens, H; Monyer, H; Pritchett, DB; Seeburg, PH; Sprengel, R | 1 |
| Kulkarni, SK; Ticku, MK | 3 |
| Harris, RA | 1 |
| Hoffer, BJ; Palmer, MR | 1 |
| Castellano, C; Populin, R | 1 |
| Kameyama, T; Nabeshima, T; Tohyama, K | 2 |
| Glowa, JR; Jeffreys, RD; Pournaghash, S; Riley, AL | 1 |
| Bygdeman, M; Eriksdotter-Nilsson, M; Granholm, AC; Hoffer, BJ; Olson, L; Palmer, MR; Seiger, A; Stieg, P; Strömberg, I | 1 |
| Crawley, JN; Paul, SM; Suzdak, PD | 1 |
| McIntyre, TD; Skolnick, P; Trullas, R | 1 |
| Becker, HC | 1 |
| Mehta, AK; Ticku, MK | 3 |
| Haefely, W | 1 |
| Brennan, CH; Lewis, A; Littleton, JM | 1 |
| Bishop, BE; Laverty, R | 1 |
| Breese, GR; McCown, TJ | 1 |
| Biggio, G; Corda, MG; Giorgi, O; Longoni, B | 2 |
| Aramo, S; Carcangiu, G; Marrosu, F; Mereu, G; Passino, N | 1 |
| Anton, RF; Becker, HC | 1 |
| Durcan, MJ; Lister, RG | 1 |
| Frost, JJ; Sadzot, B; Wagner, HN | 1 |
| Mhatre, M; Ticku, MK | 1 |
| Chiu, TH; Rosenberg, HC; Yu, OF | 1 |
| Haraguchi, M; Sadeghi, KG; Samson, HH; Tolliver, GA | 1 |
| Miller, DW; Tessel, RE; Yourick, DL | 1 |
| Galizio, M | 1 |
| Dawid-Milner, S; Díaz-Calavia, JE; Fernández del Moral, R | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG; Nutt, DJ | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG; Wozniak, KM | 1 |
| Korpi, ER; Malminiemi, O | 1 |
| Delaney, D; Poling, A; Schlinger, H | 1 |
| Michael, RP; Schaefer, GJ | 2 |
| Collins, M; Zimmerman, EF | 1 |
| Kalant, H; Khanna, JM; Le, AD; Mana, MJ; Pham, T | 1 |
| Chelazzi, L; Rossi, F; Strata, P; Tempia, F | 2 |
| Bowyer, DM; Cooper, SJ; van der Hoek, G | 1 |
| Amit, Z; Segal, RB; Smith, BR | 1 |
| Atrens, DM; Healey, PA; Menéndez, JA; Verne, SL; Wood, AL | 1 |
| Lister, RG | 4 |
| Brinton, RE; Gee, KW; McEwen, BS | 1 |
| Hatch, RC; Jernigan, AD | 1 |
| Balster, RL; Rees, DC | 1 |
| Biggio, G; Corda, MG; Fernández, A; Giorgi, O | 1 |
| Sieghart, W | 1 |
| Möhler, H; Richards, JG | 1 |
| Moody, EJ; Skolnick, P | 1 |
| Hellevuo, K; Korpi, ER | 1 |
| Hilakivi, LA; Lister, RG | 1 |
| Allan, AM; Daniell, LC; Harris, RA; Nixon, C | 1 |
| Harlan, JT; Moore, EA; Palmer, MR; van Horne, CG | 1 |
| Corda, MG; Giorgi, O; Marrosu, F; Mereu, G | 1 |
| Cau, P; Lanoir, J; Pinard, R; Segu, L | 1 |
| Lister, RG; Nutt, DJ | 5 |
| Bonetti, EP; Burkard, WP; Gabl, M; Hunkeler, W; Lorez, HP; Martin, JR; Moehler, H; Osterrieder, W; Pieri, L; Polc, P | 1 |
| Crawley, J; Glowa, JR; Paul, SM; Suzdak, PD | 1 |
| Celentano, JJ; Farb, DH; Gibbs, TT | 1 |
| Belzung, C; Misslin, R; Vogel, E | 2 |
| Eichinger, A; Sieghart, W | 1 |
| Crawley, JN; Glowa, JR; Paul, SM; Schwartz, RD; Skolnick, P; Suzdak, PD | 1 |
| Eichinger, A; Möhler, H; Richards, JG; Sieghart, W | 1 |
| Eichinger, A; Sieghart, W; Zezula, J | 1 |
| Boi, V; Carcangiu, P; Gessa, GL; Mereu, G; Passino, N | 1 |
| Firestone, LL | 1 |
| Slangen, JL; Woudenberg, F | 1 |
| Hiltunen, AJ; Järbe, TU | 2 |
| Biggio, G; Corda, MG; Giorgi, O | 1 |
| Britton, KT; Koob, GF; Percy, L | 1 |
| Blakely, E; Poling, A; Schlinger, H | 1 |
| Li, TK; Lumeng, L; McBride, WJ; Murphy, JM | 1 |
| Gallant, DM | 1 |
| Britton, KT; Ehlers, CL; Koob, GF | 1 |
| Bonetti, EP; Lister, RG; Nutt, DJ; Reese, RE; Rufener, R; Rusche, D | 1 |
| Colombo, G; Fadda, F; Gessa, GL; Mosca, E | 1 |
| Hoffman, PL; Paul, SM; Suzdak, PD; Szabó, G; Tabakoff, B | 1 |
| Mills, FG; Pfeffer, AO; Sadeghi, KG; Samson, HH; Tolliver, GA | 1 |
| Colombo, G; Fadda, F; Gessa, GL; Mosca, E; Niffoi, T | 1 |
| Benjamin, D; Harris, CM; Lal, H | 1 |
| Alkana, RL; Gee, KW; Syapin, PJ | 1 |
| Kolata, G | 1 |
| Miczek, KA; Weerts, EM | 1 |
| Hunkeler, W; Möhler, H; Richards, JG; Sieghart, W | 1 |
| Gu, ZQ; Harris, BD; Moody, EJ; Skolnick, P | 1 |
| Iwasaki, T; Nakagawa, Y | 1 |
| Chapin, JK; Lee, RS; Maddux, BN; Shimizu, N; Smith, SS; Waterhouse, BD; Woodward, DJ | 1 |
| Chapin, JK; Lee, RS; Maddus, BN; Shimizu, N; Smith, SS; Waterhouse, BD; Woodward, DJ | 1 |
| Davies, MF; Loew, GH; Maguire, PA | 1 |
| Alberts, GL; Binder, JA; Dillon, GH; Im, WB; Pregenzer, JF | 1 |
| Korpi, ER; Lüddens, H; Mäkelä, R; Wong, G | 1 |
| Baulieu, EE; Chesnoy-Marchais, D; Hauser, CA; Robel, P | 1 |
| Hansen, HC; Korpi, ER; Suzdak, PD; Uusi-Oukari, M; Wong, G | 1 |
| Elmer, GI; George, FR | 1 |
| Kettenmann, H; Kleingoor, C; Korpi, ER; Seeburg, PH | 1 |
| Cebers, G; Zharkovsky, A | 1 |
| Cook, JM; Harris, B; Liu, R; Skolnick, P; Zhang, P; Zhang, W | 1 |
| Pokk, P; Zharkovsky, A | 2 |
| Lüddens, H; Wieland, HA | 1 |
| Honkanen, A; Korpi, ER; Wegelius, K | 1 |
| Clark, M; Massenburg, GS; Post, RM; Weiss, SR | 1 |
| Miczek, KA; Tornatzky, W; Weerts, EM | 1 |
| Hughes, RW; June, HL; Lewis, MJ; Spurlock, HL | 1 |
| Cole, BJ; Hillmann, M | 1 |
| June, HL; Lewis, MJ | 1 |
| Gardner, CR; Pringle, AK; Walker, RJ | 1 |
| Andrews, N; File, SE | 1 |
| Hu, XJ; Ticku, MK | 1 |
| Dar, MS; Meng, ZH | 1 |
| Langeland, BT; McKinley-McKee, JS | 1 |
| Escorihuela, RM; Fernández-Teruel, A; Núñez, JF; Prunell, M; Tobeña, A | 1 |
| Basile, AS; Jones, EA; Skolnich, P; Yurdaydin, C | 1 |
| Stephenson, FA; Thompson, CL | 1 |
| Abiko, E; Fukuda, H; Ito, Y; Mitani, K | 1 |
| Korpi, ER; Lüddens, H; Seeburg, PH | 1 |
| Gillard, NP; McKernan, RM; Quirk, K; Ragan, CI; Whiting, PJ | 1 |
| Breese, GR; Criswell, HE | 1 |
| Korpi, ER; Seeburg, PH | 1 |
| Khan, RM; Soliman, MR | 1 |
| Karim, KH; Najim, RA | 1 |
| Ferenci, P; Herneth, A; Püspök, A; Steindl, P | 1 |
| Duggan, MJ; Pollard, S; Stephenson, FA | 1 |
| Korpi, ER; Taira, T; Uusi-Oukari, M | 1 |
| D'Amico, E; Koob, GF; Rassnick, S; Riley, E | 1 |
| Hiramatsu, M; Ishihara, S; Kameyama, T; Nabeshima, T | 1 |
| Koob, GF; Krechman, J; Rassnick, S | 1 |
| Kaivola, J; Korpi, ER; Uusi-Oukari, M | 1 |
| Basile, AS; Fromm, C; Gu, ZQ; Holt, AG; Nowak, G; Yurdaydin, C | 1 |
| Hadingham, KL; Le Bourdelles, B; Palmer, KJ; Ragan, CI; Whiting, PJ; Wingrove, P | 1 |
| Anderson, SM; Cross, AJ; De Souza, RJ | 1 |
| Barber, DJ; Cooper, SJ | 1 |
| Duncalfe, LL; Dunn, SM | 2 |
| Petry, NM | 1 |
| De Blas, AL; Gutiérrez, A; Khan, ZU | 1 |
| Pollard, S; Stephenson, FA; Thompson, CL | 1 |
| Drewe, JA; Lan, NC; Yang, W | 1 |
| Becker, HC; Jarvis, MF | 1 |
| File, SE; Hogg, S; Mills, AD | 1 |
| Stoessl, AJ | 1 |
| Ho, IK; Ito, T; Suzuki, T; Wellman, SE | 1 |
| Mehta, AK; Shank, RP | 1 |
| Ebert, V; Scholze, P; Sieghart, W | 2 |
| Pruett, SB; Wu, WJ | 1 |
| Cooper, SJ; Higgs, S | 2 |
| Fukuda, H; Ito, Y; Kobayashi, M; Segawa, K | 1 |
| Cornelius, LM; Whitmire, D; Whitmire, PS | 1 |
| Benke, D; Benson, JA; Carter, DB; Hamilton, BJ; Knoflach, F; Lüddens, H; Mohler, H; Scheurer, L; Wang, Y | 1 |
| Dzoljic, M; Dzoljic, MR; Erdmann, W | 1 |
| Anderson, S; Stone, T; Yutrzenka, GJ | 1 |
| Bucci, D; Devaud, LL; Morrow, AL; Smith, FD | 1 |
| Heyman, GM; Petry, NM | 1 |
| Liljequist, S; Pokk, P; Zharkovsky, A | 1 |
| Bateson, AN; Davies, M; Dunn, SM; Hadingham, KL; Martin, IL; Whiting, PJ | 1 |
| Inoue, O; Långström, B; Nakanishi, S; Nishiyama, S; Onoe, H; Tsukada, H; Watanabe, Y | 1 |
| Hayase, T; Yamamoto, K; Yamamoto, Y | 1 |
| France, CP; Gerak, LR | 2 |
| Berning, B; Gerner, FM; Hauser, CA; Rupprecht, R; Wetzel, CH | 1 |
| Akwa, Y; Britton, KT; Brot, MD; Koob, GF; Purdy, RH | 1 |
| Korpi, ER; Lüddens, H | 1 |
| Benke, D; Michel, C; Mohler, H | 1 |
| Firestone, LL; Homanics, GE; Korpi, ER; Mäkelä, R; Quinlan, JJ; Uusi-Oukari, M; Wisden, W | 1 |
| Barron, KW; Garrett, KM; Pavelka, SM | 1 |
| Buczek, Y; Lê, AD; Sellers, EM; Tomkins, DM | 1 |
| Anwer, J; Dar, MS; Meng, ZH | 1 |
| Acri, JB; Basile, AS; Lyon, T; Witkin, JM; Wong, G | 1 |
| Jechlinger, M; Klausberger, T; Pelz, R; Sieghart, W; Tretter, V | 1 |
| Davies, M; Dunn, SM; Thuynsma, RP | 1 |
| Bateson, AN; Davies, M; Dunn, SM | 1 |
| ffrench-Mullen, JM; Gong, QH; Hsu, FC; Li, X; Markowitz, RS; Smith, SS | 1 |
| Abiru, H; Fukui, Y; Hayase, T; Yamamoto, K; Yamamoto, Y | 1 |
| Davies, M; Dunn, SM | 1 |
| Cason, CR; Cheatham, G; Cook, JM; Gan, T; June, HL; Lui, R | 1 |
| Asuni, A; Broughton, H; Collins, I; Emms, F; Farrar, S; McKernan, RM; Quirk, K | 1 |
| Inoue, O; Mori, K; Nakano, T; Satoh, T | 1 |
| Benson, JA; Keist, R; Löw, K; Mohler, H; Rudolph, U | 1 |
| Barnes, EM; Stephenson, FA; Tehrani, MH; Thompson, CL | 1 |
| Collier, SD; Pruett, SB; Wu, WJ | 1 |
| Estupinan, LE; France, CP; Gerak, LR | 1 |
| Gatto, GJ; Grant, KA | 1 |
| Gonzalez, LP; Mhatre, MC | 1 |
| Atack, JR; Farrar, SJ; Kerby, J; McKernan, RM; Sur, C; Whiting, PJ | 1 |
| Bencsits, E; Ebert, V; Sieghart, W; Tretter, V | 1 |
| Anagnostaras, SG; Banerjee, PK; DeLorey, TM; Fanselow, MS; Firestone, LL; Guidotti, A; Homanics, GE; Korpi, ER; Lagenaur, C; Li, Z; Mi, ZP; Mihalek, RM; Olsen, RW; Quinlan, JJ; Sage, JR; Sieghart, W; Spigelman, I; Tretter, V | 1 |
| Alho, H; Anghelescu, I; Klawe, C; Korpi, ER; Lüddens, H; Mäkelä, R; Oja, SS; Uusi-Oukari, M | 1 |
| Dikic, B; Katsifis, A; Mardon, K; Mattner, F; McPhee, M; Ridley, D | 1 |
| Söderpalm, B; Svensson, AI | 1 |
| Cooper, RL; Meacham, CA; Shafer, TJ; Ward, TR | 1 |
| Pollard, S; Razzini, G; Stephenson, FA; Thompson, CL | 1 |
| Boileau, AJ; Czajkowski, C; Kucken, AM; Teissére, JA; Wagner, DA; Ward, PR | 1 |
| Atack, JR; Bristow, L; Brown, N; Carling, RW; Castro, JL; Cook, G; Dawson, GR; Farrar, S; Ferris, P; Garrett, L; Howell, O; Macaulay, A; Marshall, G; McKernan, RM; Moore, KW; Myers, J; Ragan, CI; Reynolds, DS; Rosahl, TW; Street, LJ; Sur, C; Wafford, KA; Whiting, PJ | 1 |
| Firestone, LL; Homanics, GE; Quinlan, JJ | 1 |
| France, CP; Gerak, LR; Lelas, S | 1 |
| Broersen, LM; Feldon, J; Lacroix, L; Spinelli, S | 1 |
| Korpi, ER; Lüddens, H; Panula, P; Särkioja, T; Sinkkonen, ST; Tiihonen, J; Tupala, E; Uusi-Oukari, M | 1 |
| Hevers, W; Korpi, ER; Lüddens, H | 1 |
| Gonzalez, LP; McKenzie, SE; Mhatre, MC | 1 |
| Bromidge, FA; Casula, MA; Hadingham, KL; Martin, K; Maubach, K; Pillai, GV; Seabrook, GR; Whiting, PJ; Wingrove, PB | 1 |
| Paz, L; Peter, Y; Pick, CG; Weizman, R | 1 |
| Arnot, MI; Bateson, AN; Davies, M; Martin, IL | 1 |
| Fanselow, M; Olsen, RW; Park, MK; Petrie, J; Sapp, DW; Tyndale, RF | 1 |
| Cook, JM; DeLorey, TM; He, X; Lameh, J; Lin, RC; Loew, GH; McBrady, B | 1 |
| Al-Mulla Hummadi, YM; Farjou, IB; Najim, RA | 1 |
| Pokk, P; Väli, M | 1 |
| Grant, KA; Shelton, KL | 1 |
| Atack, J; Banks, G; Kelly, MD; Maubach, KA; Seabrook, GR; Smith, A; Whiting, PW; Wingrove, P | 1 |
| France, CP; McMahon, LR | 1 |
| Hauer, B; Hevers, W; Homanics, GE; Korpi, ER; Lüddens, H; Mihalek, RM; Sieghart, W; Sinkkonen, ST | 1 |
| Kakiuchi, T; Kuhara, S; Nishiyama, S; Takahashi, K; Tonchev, AB; Tsukada, H; Wang, XD; Yamashima, T; Yamashita, J; Zhao, L | 1 |
| Dämgen, K; Davids, E; Hevers, W; Lüddens, H; Tarazi, FI; Zhang, K | 1 |
| Brooks, DJ; Cunningham, VJ; Feeney, A; Hirani, E; Hume, SP; Lingford-Hughes, A; Nutt, DJ; Osman, S; Pike, VW | 1 |
| Obeng, K; Post, RM; Postma, T; Russell, S; Weiss, SR; Zhang, ZJ | 1 |
| Gatch, MB; Jung, ME; Lal, H; Wallis, CJ | 1 |
| Assandri, R; Crestani, F; Martin, JR; Rudolph, U; Täuber, M | 1 |
| Chiara, DC; Cohen, JB; Olsen, RW; Sawyer, GW | 1 |
| Cagetti, E; Liang, J; Olsen, RW; Spigelman, I | 2 |
| Hojo, J; Kawabe, K; Maeda, J; Obayashi, S; Okauchi, T; Suhara, T; Suzuki, K | 1 |
| Faber, DS; Hsu, FC; Smith, SS; Waldeck, R | 1 |
| Noguchi, J; Suzuki, K | 1 |
| Akaike, S; Fukumura, T; Suzuki, K; Yoshida, Y | 1 |
| Hayase, T; Muso, E; Shiota, K; Yamamoto, K; Yamamoto, Y | 1 |
| Kida, T; Noguchi, J; Suhara, T; Suzuki, K; Zhang, MR | 1 |
| Hayase, T; Hayashi, T; Muso, E; Shiota, K; Yamamoto, K; Yamamoto, Y | 1 |
| Korpi, ER; Lüddens, H; Lüscher, B; Sinkkonen, ST | 1 |
| Foster, AC; Grigoriadis, DE; Gross, RS; Petroski, RE; Sullivan, SK; Verge, G | 1 |
| Baur, R; Berezhnoy, D; Foucaud, B; Goeldner, M; Gonthier, A; Sigel, E | 1 |
| Abe, K; Amitani, M; Hosoi, R; Inoue, O; Kobayashi, K; Umetani, Y | 1 |
| Goldstein, PA; Harrison, NL; Jia, F; Pignataro, L; Schofield, CM; Yue, M | 1 |
| Atack, JR; Cook, SM; McKernan, RM; Pym, LJ; Rosahl, T | 1 |
| Fuchs, K; Furtmüller, B; Höger, H; Homanics, GE; Lehner, R; Ogris, W; Sieghart, W | 1 |
| Ahboucha, S; Butterworth, RF; Coyne, L; Halliwell, RF; Hirakawa, R | 1 |
| Hirano, S; Kamei, J; Miyata, S | 1 |
| Chutsrinopkun, P; Hanchar, HJ; Meera, P; Olsen, RW; Sieghart, W; Supavilai, P; Wallner, M | 1 |
| Hanchar, HJ; Olsen, RW; Wallner, M | 2 |
| France, CP; Gerak, LR; McMahon, LR | 1 |
| Paul, SM | 1 |
| Marszalec, W; Narahashi, T; Yamashita, M; Yeh, JZ | 1 |
| Aller, MI; Böhme, I; Debus, F; Korpi, ER; Leppä, E; Linden, AM; Lüddens, H; Malécot, C; Rabe, H; Vekovischeva, O; Wisden, W | 1 |
| Hanchar, HJ; Meera, P; Olsen, RW; Wallner, M | 1 |
| Marutha Ravindran, CR; Mehta, AK; Ticku, MK | 1 |
| Besson, M; Dawson, GR; Lingford-Hughes, AR; Nutt, DJ; Wilson, SJ | 1 |
| Ives, JH; Payne, HL; Sieghart, W; Thompson, CL | 1 |
| Ando, T; Arakawa, R; Asai, K; Asai, Y; Ito, H; Ito, S; Matsuura, M; Okubo, Y; Otsuka, A; Suhara, T; Takahashi, H; Takano, A | 1 |
| Chandra, D; Homanics, GE; Liang, J; Olsen, RW; Spigelman, I; Suryanarayanan, A | 1 |
| Olsen, RW; Wallner, M | 1 |
| Atack, JR; Dawson, GR; Morris, HV; Reynolds, DS; Rosahl, TW; Stephens, DN | 1 |
| Grant, KA; Helms, CM; Rogers, LS; Waters, CA | 1 |
| Grant, KA; Helms, CM; Rogers, LS | 1 |
| Asai, Y; Ichimiya, T; Ikoma, Y; Ito, H; Maeda, J; Suhara, T; Takano, A; Toyama, H; Yasuno, F | 1 |
| Glass, JD; McElroy, B; Prosser, RA; Zakaria, A | 1 |
| Dubiela, FP; Hipólide, DC; Moreira, KM; Nobrega, JN; Oliveira, MG; Tufik, S | 1 |
| Atack, JR; Belelli, D; Breen, G; Desrivieres, S; Dixon, CI; Guindalini, C; Jugurnauth, S; King, SL; Lambert, JJ; Laranjeira, R; Messas, G; Morris, HV; Peden, DR; Rosahl, TW; Schumann, G; Steiner, RC; Stephens, DN; Vallada, H | 1 |
| Hellsten, KS; Hyde, TM; Kleinman, JE; Korpi, ER; Maksimow, A; Särkioja, T; Sinkkonen, ST; Uusi-Oukari, M | 1 |
| Abe, K; Hosoi, R; Inoue, O; Momosaki, S | 1 |
| Meera, P; Olsen, RW; Otis, TS; Wallner, M | 1 |
| Brooks, DJ; Feeney, A; Grasby, P; Hammers, A; Lingford-Hughes, A; Myers, J; Nutt, DJ; Reid, AG; Rosso, L; Taylor, LG; Turkheimer, F | 1 |
| Aalto, AJ; Kontturi, LS; Uusi-Oukari, M; Wallner, M | 1 |
| Boehm, SL; Melón, LC | 1 |
| Korpi, ER; Leppä, E; Linden, AM; Lüddens, H; Rabe, H; Vekovischeva, OY; Wisden, W; Wulff, P | 1 |
| Contó, MB; de Carvalho, JG; Hipólide, DC; Venditti, MA | 1 |
| Bakalkin, G; Chefer, V; Kuzmin, A; Liljequist, S; Meis, J; Shippenberg, T | 1 |
| Brooks, DJ; Clementi, N; Kalk, NJ; Lingford-Hughes, AR; Myers, JF; Nutt, DJ; Rosso, L; Turkheimer, FE; Watson, BJ; Wilson, SJ | 1 |
| Ishibashi, H; Nabekura, J; Nielsen, M; Witt, MR | 1 |
| Cunningham, VJ; Erritzoe, D; Hammers, A; Kalk, NJ; Lingford-Hughes, AR; Myers, JF; Nutt, DJ; Riano Barros, D; Stokes, PR; Turkheimer, FE; Watson, BJ; Wilson, SJ | 1 |
| De Santis, V; Lingford-Hughes, A; Myers, J; Nutt, D; Parker, C; Quelch, D; Strege, A; Tyacke, R; Wells, L | 1 |
| Banks, ML; Shelton, KL; Tracy, ME | 1 |
| Brooks, DJ; Feeney, A; Hammers, A; Kalk, N; Lingford-Hughes, A; McGinnity, CJ; Myers, J; Nutt, DJ; Reid, AG; Riaño-Barros, DA; Rosso, L; Taylor, LG; Turkheimer, F; Watson, B | 1 |
| Bender, D; Blicher, JU; Brooks, DJ; Hansen, KV; Jakobsen, S; Lou, HC; Møller, A; Rosenstand, A | 1 |
| Chiou, LC; Fan, PC; Huang, WJ; Lee, HJ; Liao, YH | 1 |
| Comley, RA; Gunn, RN; Myers, JF | 1 |
| Bowden-Jones, H; Chandrasekera, S; Clark, L; Erritzoe, D; Galduróz, JCF; Gunn, RN; Lingford-Hughes, AR; Mendez, MA; Mick, I; Myers, J; Nutt, DJ; Rabiner, EA; Ramos, AC; Searle, GE; Stokes, PR; Waldman, AD | 1 |
| Bertelsen, F; Drasbek, KR; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J | 1 |
| Bertoldo, A; Hammers, A; Hinz, R; Koepp, MJ; McGinnity, CJ; Riaño Barros, DA; Rizzo, G; Rosso, L; Turkheimer, FE; Veronese, M | 1 |
| Andersson, M; Bölte, S; Borg, J; Cash, D; Farde, L; Gee, A; Halldin, C; Higgins, K; Horder, J; Howes, OD; Lingford-Hughes, A; Lundberg, J; Mendez, MA; Mick, I; Murphy, DG; Nutt, DJ; Selvaraj, S; Sementa, T; Singh, N; Spain, D; Tangen, Ä; Turkheimer, F; Veronese, M | 1 |
| Blicher, JU; Brooks, DJ; Hansen, KV; Lou, HC; Mouridsen, K; Møller, A; Rømer Thomsen, K | 1 |
| Flaus, A; Hammers, A; Hinz, R; Koepp, MJ; Lingford-Hughes, A; McGinnity, CJ; Myers, JF; Riaño Barros, DA | 1 |
| Benkherouf, AY; Kortesniemi, M; Laaksonen, O; Logrén, N; Salo-Ahen, OMH; Soini, SL; Somborac, T; Uusi-Oukari, M; Yang, B | 1 |
| Jansen, LA; Joshi, S; Kapur, J; Roden, WH | 1 |
15 review(s) available for azides and ro 15-4513
| Article | Year |
|---|---|
Cerebellar GABAA receptors and alcohol-related behaviors: focus on diazepam-insensitive [3H]Ro 15-4513 binding.
Topics: Animals; Azides; Behavior; Behavior, Animal; Benzodiazepines; Cerebellum; Diazepam; Ethanol; Humans; Receptors, GABA-A | 1992 |
Alcohol and GABA-benzodiazepine receptor function.
Topics: Alcoholism; Animals; Azides; Behavior; Benzodiazepines; Chlorides; Ethanol; Humans; Ion Channels; Receptors, GABA-A | 1990 |
GABAergic mechanisms in the electrophysiological actions of ethanol on cerebellar neurons.
Topics: Action Potentials; Animals; Azides; Benzodiazepines; Carbolines; Cerebellum; Dose-Response Relationship, Drug; Ethanol; gamma-Aminobutyric Acid; Male; Neural Inhibition; Rats; Rats, Inbred Strains | 1990 |
Ethanol and the benzodiazepine-GABA receptor-ionophore complex.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Ethanol; Ionophores; Motor Activity; Receptors, GABA-A | 1989 |
Pharmacology of acute alcoholic intoxication.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Brain; Cell Membrane; Ethanol; Humans; Naloxone; Neurons; Receptors, GABA-A; Receptors, Opioid | 1989 |
The benzodiazepine receptor: a pharmacological control element of brain function.
Topics: Animals; Azides; Benzodiazepines; Brain; Electrophysiology; gamma-Aminobutyric Acid; Midazolam; Models, Molecular; Receptors, GABA-A | 1988 |
Molecular interactions of ethanol with GABAergic system and potential of RO15-4513 as an ethanol antagonist.
Topics: Animals; Azides; Benzodiazepines; Ethanol; Humans; Receptors, GABA-A | 1988 |
RO 15-4513 and its interaction with ethanol.
Topics: Animals; Azides; Benzodiazepines; Drug Interactions; Ethanol; Mice; Pentobarbital; Rats; Receptors, GABA-A; Saimiri | 1988 |
General anesthetics.
Topics: Anesthetics; Animals; Azides; Benzodiazepines; Enzyme Activation; Halothane; Luciferases; Membrane Lipids; Membrane Proteins; Protein Kinase C | 1988 |
Alcohol: effects on GABAA receptor function and gene expression.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Ethanol; Gene Expression; Rats; Receptors, GABA-A; RNA, Messenger | 1993 |
Do benzodiazepine ligands contribute to hepatic encephalopathy?
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Disease Models, Animal; Flumazenil; GABA-A Receptor Antagonists; Hepatic Encephalopathy; Humans; Ligands; Receptors, GABA-A | 1993 |
Methods for transient expression of hetero-oligomeric ligand-gated ion channels.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Humans; Ion Channel Gating; Ion Channels; Ligands; Muscimol; Receptors, GABA-A; Transfection | 1997 |
Does ethanol act preferentially via selected brain GABAA receptor subtypes? the current evidence is ambiguous.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Central Nervous System Depressants; Drug Tolerance; Ethanol; Humans; Mice; Rats; Receptors, GABA-A | 2007 |
GABAA receptor subtypes: the "one glass of wine" receptors.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Ethanol; Humans; Receptors, GABA-A; Wine | 2007 |
Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?
Topics: Acetaldehyde; Alcoholism; Animals; Azides; Behavior, Addictive; Benzodiazepines; Binding, Competitive; Central Nervous System Depressants; Dose-Response Relationship, Drug; Drug Design; Ethanol; GABA Antagonists; GABA-A Receptor Antagonists; Humans; Protein Binding; Receptors, GABA-A | 2008 |
3 trial(s) available for azides and ro 15-4513
| Article | Year |
|---|---|
Blockade of alcohol's amnestic activity in humans by an alpha5 subtype benzodiazepine receptor inverse agonist.
Topics: Adult; Affinity Labels; Alcohols; Amnesia; Anti-Anxiety Agents; Azides; Benzodiazepines; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; GABA Agonists; Humans; Male; Models, Biological; Neuropsychological Tests; Severity of Illness Index; Sleep; Time Factors; Tomography, Emission-Computed | 2007 |
Characterisation of the contribution of the GABA-benzodiazepine α1 receptor subtype to [(11)C]Ro15-4513 PET images.
Topics: Adult; Affinity Labels; Azides; Benzodiazepines; Brain; Double-Blind Method; GABA-A Receptor Agonists; Humans; Male; Middle Aged; Positron-Emission Tomography; Protein Binding; Protein Subunits; Pyridines; Radiography; Receptors, GABA-A; Zolpidem | 2012 |
Acute increases in synaptic GABA detectable in the living human brain: a [¹¹C]Ro15-4513 PET study.
Topics: Adult; Azides; Benzodiazepines; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Double-Blind Method; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Memory; Middle Aged; Nipecotic Acids; Positron-Emission Tomography; Psychomotor Performance; Radiopharmaceuticals; Receptors, GABA-A; Synapses; Tiagabine | 2014 |
346 other study(ies) available for azides and ro 15-4513
| Article | Year |
|---|---|
Ethanol modulation of GABA receptor-activated Cl- currents in neurons of the chick, rat and mouse central nervous system.
Topics: Animals; Azides; Benzodiazepines; Brain; Cells, Cultured; Chickens; Chloride Channels; Chlorides; Electrophysiology; Ethanol; Ion Channels; Male; Membrane Proteins; Mice; Neurons; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 1992 |
High affinity ligands for 'diazepam-insensitive' benzodiazepine receptors.
Topics: Animals; Azides; Benzodiazepines; Diazepam; gamma-Aminobutyric Acid; Male; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship | 1992 |
Ethanol self-administration in deprived rats: effects of Ro15-4513 alone, and in combination with flumazenil (Ro15-1788).
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Brain; Flumazenil; Male; Motivation; Rats; Rats, Inbred Strains; Receptors, GABA-A; Self Administration; Taste | 1992 |
Substrate specificity of diazepam-insensitive cerebellar [3H]Ro 15-4513 binding sites.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Binding, Competitive; Cerebellum; Diazepam; Ethanol; GABA-A Receptor Antagonists; Ligands; Male; Membranes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensitivity and Specificity; Substrate Specificity; Tritium | 1992 |
Effect of diethyl pyrocarbonate modification of benzodiazepine receptors on [3H]Ro 15-4513 binding.
Topics: Animals; Appetite Depressants; Azides; Benzodiazepines; Carbolines; Cerebellum; Cerebral Cortex; Diazepam; Diethyl Pyrocarbonate; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Tritium | 1992 |
Characterization of two cerebellar binding sites of [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cell Membrane; Cerebellum; Chromatography, Affinity; Diazepam; Flunitrazepam; Receptors, GABA-A; Swine; Tritium | 1992 |
Cerebellar and frontal cortical benzodiazepine receptors in human alcoholics and chronically alcohol-drinking rats.
Topics: Adult; Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Brain; Cerebellum; Diazepam; Female; Frontal Lobe; Humans; Ligands; Male; Middle Aged; Models, Biological; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Characteristics of two cerebellar binding sites of [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Diazepam; In Vitro Techniques; Kinetics; Receptors, GABA-A; Swine; Synaptic Membranes; Synaptosomes | 1992 |
Ro 15-4513 binding to GABAA receptors: subunit composition determines ligand efficacy.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Cerebellum; Diazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics; Ligands; Male; Muscimol; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1992 |
Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Flumazenil; Flunitrazepam; Male; Mice; Morphine; Receptors, GABA-A; Substance Withdrawal Syndrome | 1992 |
Involvement of gamma-aminobutyric acid and N-methyl-D-aspartate receptors in the inhibitory effect of ethanol on pentylenetetrazole-induced c-fos expression in rat brain.
Topics: Animals; Azides; Benzodiazepines; Brain; Ethanol; Male; N-Methylaspartate; Pentylenetetrazole; Picrotoxin; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 1992 |
[11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Binding, Competitive; Brain Chemistry; Chromatography, High Pressure Liquid; Clonazepam; Humans; In Vitro Techniques; Macaca fascicularis; Male; Receptors, GABA-A; Tomography, Emission-Computed | 1992 |
Effects of benzodiazepine receptor inverse agonists on locomotor activity and exploration in mice.
Topics: Animals; Azepines; Azides; Benzodiazepines; Benzodiazepinones; Exploratory Behavior; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A | 1992 |
Modification of benzodiazepine receptors supports the distinctive role of histidine residues.
Topics: Animals; Azides; Benzodiazepines; Brain; Diethyl Pyrocarbonate; Epoxy Compounds; Histidine; In Vitro Techniques; Male; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship; Tetranitromethane; Tritium | 1992 |
Stable expression of type I gamma-aminobutyric acidA/benzodiazepine receptors in a transfected cell line.
Topics: Animals; Azides; Benzodiazepines; Blotting, Northern; Blotting, Southern; Cell Line; Flunitrazepam; Humans; Male; Plasmids; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Transfection | 1992 |
A single histidine in GABAA receptors is essential for benzodiazepine agonist binding.
Topics: Affinity Labels; Amino Acid Sequence; Anti-Anxiety Agents; Azides; Base Sequence; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Chimera; Histidine; Humans; Kinetics; Macromolecular Substances; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Conformation; Receptors, GABA-A; Transfection | 1992 |
GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats.
Topics: 2-Amino-5-phosphonovalerate; Acamprosate; Animals; Azides; Benzodiazepines; Choice Behavior; Convulsants; Ethanol; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamates; Infusions, Parenteral; Male; Nucleus Accumbens; Organophosphorus Compounds; Rats; Receptors, GABA-A; Receptors, Glutamate; Receptors, Neurotransmitter; Self Administration; Taurine | 1992 |
Modulation of GABAergic transmission by ethanol.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain Chemistry; Ethanol; Female; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Pentylenetetrazole; Rats; Rats, Inbred Strains; RNA, Messenger; Seizures; Synaptic Transmission | 1992 |
Chronic ethanol administration alters gamma-aminobutyric acidA receptor gene expression.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Binding Sites; Cerebellum; Cerebral Cortex; Ethanol; Gene Expression; Macromolecular Substances; Male; Molecular Sequence Data; Poly A; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA; RNA, Messenger; Time Factors; Tritium | 1992 |
Selective antagonism of acute ethanol-induced motor disturbances by centrally administered Ro 15-4513 in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electrodes, Implanted; Ethanol; Injections, Intraventricular; Male; Mice; Motor Activity; Pentobarbital; Pentylenetetrazole; Psychomotor Performance; Seizures | 1992 |
Effect of Ro 15-4513 on ethanol-induced conditioned place preference.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Ethanol; Habituation, Psychophysiologic; Male; Mice; Mice, Inbred DBA; Motor Activity | 1992 |
In vivo binding of [11C]Ro15-4513 in human brain measured with PET.
Topics: Adult; Azides; Benzodiazepines; Brain; Flumazenil; Humans; Ligands; Male; Tomography, Emission-Computed | 1992 |
Failure of Ro15-4513 to alter an ethanol-induced taste aversion.
Topics: Animals; Azides; Benzodiazepines; Ethanol; Male; Rats; Rats, Inbred Strains; Saccharin; Taste | 1992 |
Learning and memory-enhancing effects of Ro 15-4513: a comparison with flumazenil.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Discrimination Learning; Flumazenil; Learning; Memory; Mice; Mice, Inbred ICR; Scopolamine; Stimulation, Chemical | 1992 |
Effect of a benzodiazepine derivate Ro 15-4513 on ethanol-free selection and CNS mitochondrial energetics in rats.
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Brain; Electron Transport; Female; Male; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Rats; Rats, Inbred Strains; Sex Characteristics | 1992 |
The benzodiazepine/alcohol antagonist Ro 15-4513: binding to a GABAA receptor subtype that is insensitive to diazepam.
Topics: Allosteric Regulation; Animals; Azides; Benzodiazepines; Cattle; Cerebellum; Cerebral Cortex; Diazepam; Ethanol; Humans; In Vitro Techniques; Kinetics; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Transient increase in [3H]Ro 15-4513 specific binding in the superficial gray layer of the rat superior colliculus induced by visual deafferentation.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Bicuculline; Binding, Competitive; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mesencephalon; Neurons, Afferent; Ocular Physiological Phenomena; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, GABA-A; Superior Colliculi; Vision, Ocular; Visual Cortex | 1991 |
The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Electroencephalography; Evoked Potentials, Visual; Flumazenil; Hepatic Encephalopathy; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Effects of Ro 15-4513 on ethanol discrimination in C57BL/6 mice.
Topics: Animals; Azides; Benzodiazepines; Discrimination Learning; Ethanol; Female; Mice; Mice, Inbred C57BL; Receptors, GABA-A; Time Factors | 1991 |
Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor alpha 4 subunit.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Base Sequence; Benzodiazepines; Binding, Competitive; Brain; Cloning, Molecular; Kinetics; Macromolecular Substances; Molecular Sequence Data; Muscimol; Oligodeoxyribonucleotides; Organ Specificity; Rats; Receptors, GABA-A; Recombinant Proteins; RNA, Messenger | 1991 |
Benzodiazepine receptor ligands and hepatic encephalopathy: further unfolding of the GABA story.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Central Nervous System; Flumazenil; gamma-Aminobutyric Acid; Hepatic Encephalopathy; Humans; Ligands; Neurons; Receptors, GABA-A; Synaptic Transmission | 1991 |
Beneficial effect of pharmacological modulation of the GABAA-benzodiazepine receptor on hepatic encephalopathy in the rat: comparison with uremic encephalopathy.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Benzodiazepinones; Coma; Flumazenil; Hepatic Encephalopathy; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Uremia | 1991 |
In vivo bidirectional modulatory effect of benzodiazepine receptor ligands on GABAergic transmission evaluated by positron emission tomography in non-human primates.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Carbolines; Cerebral Cortex; Diazepam; Electroencephalography; Flumazenil; gamma-Aminobutyric Acid; Ligands; Male; Papio; Pentylenetetrazole; Receptors, GABA-A; Seizures; Synaptic Transmission; Tomography, Emission-Computed | 1991 |
Modulation of benzodiazepine agonist and inverse-agonist receptor binding by GABA during ethanol withdrawal.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Cerebellum; Cerebral Cortex; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Hippocampus; Male; Rats; Receptors, GABA-A; Substance Withdrawal Syndrome; Synaptic Transmission | 1991 |
Histidine residue is crucial for the binding of ligands to the benzodiazepine site except Ro15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Cerebral Cortex; Diethyl Pyrocarbonate; Flunitrazepam; Histidine; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1991 |
Inverse but not full benzodiazepine agonists modulate recombinant alpha 6 beta 2 gamma 2 GABAA receptors in transfected human embryonic kidney cells.
Topics: Action Potentials; Azides; Benzodiazepines; Carbolines; Cells, Cultured; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Humans; Kidney; Receptors, GABA-A; Recombinant Proteins; Transfection | 1991 |
Differences of distribution between RO 15-1788 and RO 15-4513 in vivo.
Topics: Animals; Azides; Benzodiazepines; Brain; Flumazenil; Male; Mice | 1991 |
The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Male; Pentobarbital; Rats; Rats, Inbred Strains | 1991 |
Involvement of the GABAA/benzodiazepine chloride ionophore receptor complex in the 5,7-DHT Induced anticonflict effect.
Topics: 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Bicuculline; Diazepam; Drinking Behavior; Electroshock; Flumazenil; Hippocampus; Injections, Intraventricular; Limbic System; Male; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Serotonin | 1991 |
RO15-4513 antagonizes the anxiolytic effects of ethanol in a nonshock conflict task at doses devoid of anxiogenic activity.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Conflict, Psychological; Consummatory Behavior; Ethanol; Male; Rats; Rats, Inbred Strains | 1991 |
Ex vivo binding of t-[35S )butylbicyclophosphorothionate: a biochemical tool to study the pharmacology of ethanol at the gamma-aminobutyric acid-coupled chloride channel.
Topics: Animals; Azides; Benzodiazepines; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Convulsants; Diazepam; Drug Interactions; Ethanol; gamma-Aminobutyric Acid; Ion Channels; Isoniazid; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sulfur Radioisotopes | 1991 |
Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors.
Topics: Animals; Azides; Benzodiazepines; Carbolines; GABA Antagonists; Isoniazid; Kindling, Neurologic; Male; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Seizures; Strychnine | 1991 |
Comparison of the effects of benzodiazepine and beta-carboline inverse agonists on body temperature in mice.
Topics: Animals; Azepines; Azides; Benzodiazepines; Benzodiazepinones; Body Temperature; Carbolines; Injections, Intraperitoneal; Male; Mice | 1991 |
Convulsive thresholds in mice during the recovery phase from anaesthesia induced by propofol, thiopentone, methohexitone and etomidate.
Topics: Anesthesia, Intravenous; Animals; Anticonvulsants; Azides; Behavior, Animal; Benzodiazepines; Etomidate; Male; Methohexital; Mice; Movement; Pentylenetetrazole; Propofol; Seizures; Thiopental | 1991 |
Ro15-4513 attenuates the consumption of ethanol in deprived rats.
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Male; Motivation; Rats; Rats, Inbred Strains; Taste; Water Deprivation | 1991 |
Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Azides; Benzodiazepines; Bicuculline; Blood Pressure; Brain Stem; Ethanol; Heart Rate; Male; Microinjections; Muscimol; Pressoreceptors; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reflex | 1990 |
Differential interactions of Ro 15-4513 with benzodiazepines, ethanol and pentobarbital.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; Female; Flumazenil; Male; Muscle Contraction; Muscles; Pentobarbital; Rats; Rats, Inbred Strains; Urethane; Vocalization, Animal | 1990 |
Effects of ethanol and Ro 15-4513 in an electrophysiological model of anxiolytic action.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Ethanol; Hippocampus; Male; Models, Neurological; Rats; Rats, Inbred Strains; Reference Values; Reticular Formation | 1990 |
Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat.
Topics: Anesthesia Recovery Period; Animals; Azides; Benzodiazepines; Carbolines; Flumazenil; Halothane; Male; Pentobarbital; Random Allocation; Rats; Rats, Inbred Strains; Reflex | 1990 |
Unusual behavioral profile of alprazolam in squirrel monkeys.
Topics: Alprazolam; Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Electroshock; Flumazenil; Injections, Intravenous; Lorazepam; Male; Psychomotor Performance; Saimiri | 1990 |
Reversal of the behavioral and electrophysiological abnormalities of an animal model of hepatic encephalopathy by benzodiazepine receptor ligands.
Topics: Animals; Azides; Benzodiazepines; Disease Models, Animal; Electrophysiology; Evoked Potentials, Visual; Flumazenil; Hepatic Encephalopathy; Ligands; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Diazepam sensitivity of the binding of an imidazobenzodiazepine, [3H]Ro 15-4513, in cerebellar membranes from two rat lines developed for high and low alcohol sensitivity.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Diazepam; Drug Tolerance; Ethanol; Membranes; Molecular Weight; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.
Topics: Animals; Azides; Benzodiazepines; Brain; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitrazepam; GABA Antagonists; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Pyridazines; Receptors, GABA-A; Substance Withdrawal Syndrome; Tritium | 1990 |
Ethanol-induced limb defects in mice: effect of strain and Ro15-4513.
Topics: Abnormalities, Drug-Induced; Animals; Azides; Benzodiazepines; Ethanol; Female; Fetal Resorption; Forelimb; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Pregnancy; Radiography; Receptors, GABA-A | 1990 |
Interactions between benzodiazepine antagonists, inverse agonists, and acute behavioral effects of ethanol in mice.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA-A Receptor Antagonists; Hypothermia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Receptors, GABA-A; Reflex | 1990 |
Flunitrazepam photoaffinity labeling of the GABA(A) receptor reduces inhibition of [3H]Ro15-4513 binding by GABA.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Chick Embryo; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Membranes; Photochemistry; Receptors, GABA-A | 1990 |
EEG effects of Ro 15-4513 and FG 7142 alone and in combination with ethanol.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cerebral Cortex; Drug Interactions; Electroencephalography; Ethanol; Hippocampus; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Cerebellar GABAA receptor selective for a behavioural alcohol antagonist.
Topics: Amino Acid Sequence; Animals; Azides; Base Sequence; Benzodiazepines; Binding Sites; Binding, Competitive; Cattle; Cerebellum; DNA; Ethanol; Immunosorbent Techniques; Molecular Sequence Data; Muscimol; Nucleic Acid Hybridization; Phosphorylation; Rats; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Nucleic Acid | 1990 |
Chronic benzodiazepine antagonist treatment and its withdrawal upregulates components of GABA-benzodiazepine receptor ionophore complex in cerebral cortex of rat.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Convulsants; Flumazenil; Flunitrazepam; gamma-Aminobutyric Acid; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values; Up-Regulation | 1990 |
Alcohol sensitivity.
Topics: Animals; Azides; Benzodiazepines; Cerebellum; Ethanol; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Effect of ethanol on memory consolidation in mice: antagonism by the imidazobenzodiazepine Ro 15-4513 and decrement by familiarization with the environment.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Male; Mental Recall; Mice; Mice, Inbred Strains; Reaction Time; Retention, Psychology | 1990 |
Involvement of AChergic systems in chlordiazepoxide induced impairment of passive avoidance response.
Topics: Acetylcholine; Affinity Labels; Animals; Avoidance Learning; Azides; Benzodiazepines; Cerebral Cortex; Chlordiazepoxide; Choline; Hippocampus; Kinetics; Male; Mice; Mice, Inbred Strains; Physostigmine; Reference Values; Scopolamine | 1990 |
The effects of Ro 15-4513 on ethanol-induced taste aversions.
Topics: Animals; Avoidance Learning; Azides; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Drinking Behavior; Drug Interactions; Ethanol; Female; Rats; Saccharin; Taste | 1990 |
Electrophysiologic effects of ethanol in human brain xenografts in oculo: antagonism by Ro15-4513.
Topics: Animals; Azides; Benzodiazepines; Brain; Electrophysiology; Ethanol; Eye; Humans; Nerve Tissue; Rats; Rats, Nude; Transplantation, Heterologous | 1990 |
Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Carbolines; Chlorides; Ethanol; Ion Channels; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Differences in the biophysical properties of the benzodiazepine/gamma-aminobutyric acid receptor chloride channel complex in the long-sleep and short-sleep mouse lines.
Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Heart; Ion Channels; Male; Mice; Mice, Mutant Strains; Receptors, GABA-A; Sleep | 1988 |
Effects of the imidazobenzodiazepine RO15-4513 on the stimulant and depressant actions of ethanol on spontaneous locomotor activity.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Chlorides; Ethanol; Flumazenil; Ion Channels; Male; Mice; Mice, Inbred C3H; Motor Activity; Receptors, GABA-A | 1988 |
Ethanol potentiation of GABAergic transmission in cultured spinal cord neurons involves gamma-aminobutyric acidA-gated chloride channels.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cells, Cultured; Chlorine; Ethanol; Female; Flumazenil; GABA Antagonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Inbred C57BL; Neurons; Radioisotopes; Spinal Cord | 1988 |
Partial agonists of the benzodiazepine receptor: from animal data to results in patients.
Topics: Affinity Labels; Allosteric Site; Animals; Azides; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Chlorides; Clonazepam; Diazepam; Drug Interactions; Ethanol; Flumazenil; Flurazepam; Humans; Ion Channels; Ligands; Models, Neurological; Neurons; Receptors, GABA-A | 1988 |
Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Azides; Benzodiazepines; Bicuculline; Calcium Channels; Carbachol; Catecholamines; Cattle; Cells, Cultured; Ethanol; Nitrendipine; Receptors, GABA-A; Receptors, Nicotinic; Time Factors; Up-Regulation | 1989 |
Dose-dependent reduction by Ro 15-4513 in mice of the effects of ethanol and some other general depressant drugs.
Topics: Anesthetics; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Mice; Sleep; Time Factors | 1989 |
Ethanol-induced locomotor stimulation in C57BL/6 mice following RO15-4513 administration.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Ethanol; Flumazenil; Male; Mice; Mice, Inbred C57BL; Motor Activity | 1989 |
Mechanistic and functional divergence between thyrotropin-releasing hormone and RO 15-4513 interactions with ethanol.
Topics: Animals; Arousal; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Inferior Colliculi; Male; Motor Activity; Rats; Rats, Inbred Strains; Seizures; Thyrotropin-Releasing Hormone | 1989 |
Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Conflict, Psychological; Convulsants; Flumazenil; Isoniazid; Male; Pentobarbital; Punishment; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Antagonism of ethanol effects by Ro 15-4513: an electrophysiological analysis.
Topics: Action Potentials; Animals; Azides; Behavior, Animal; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Ethanol; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Substantia Nigra | 1989 |
The benzodiazepine receptor inverse agonist RO15-4513 exacerbates, but does not precipitate, ethanol withdrawal in mice.
Topics: Acoustic Stimulation; Affinity Labels; Animals; Azides; Benzodiazepines; Ethanol; Male; Mice; Mice, Inbred C3H; Receptors, GABA-A; Seizures; Substance Withdrawal Syndrome | 1989 |
Reduction of the intoxicating effects of ethanol by drugs acting at the benzodiazepine-GABA receptor complex.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Carbolines; Drug Interactions; Ethanol; Male; Mice; Picrotoxin; Receptors, GABA-A | 1989 |
Chronic ethanol treatment alters the behavioral effects of Ro 15-4513, a partially negative ligand for benzodiazepine binding sites.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Drug Interactions; Ethanol; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1989 |
In vivo labeling of central benzodiazepine receptors with the partial inverse agonist [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A | 1989 |
Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Cells, Cultured; Female; Flumazenil; Flunitrazepam; Male; Mice; Mice, Inbred C57BL; Neurons; Receptors, GABA-A; Spinal Cord | 1989 |
Photoaffinity labeling of [3H]flunitrazepam- and [3H]Ro15-4513-bound pellets in rat cerebral cortex and cerebellum.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Suspensions; Synaptic Membranes; Time Factors | 1989 |
Antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonists Ro15-4513 and FG 7142: relation to sucrose reinforcement.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flumazenil; Male; Rats; Receptors, GABA-A; Reinforcement, Psychology; Self Administration; Sucrose | 1989 |
Antagonism of methoxyflurane-induced anesthesia in rats by benzodiazepine inverse agonists.
Topics: Anesthesia; Animals; Azides; Benzodiazepines; Carbolines; Electric Stimulation; Ketamine; Male; Methoxyflurane; Pain; Pain Measurement; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reflex; Respiration | 1989 |
Attenuation of the biphasic effects of ethanol on avoidance extinction by RO 15-4513 in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; GABA-A Receptor Antagonists; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1989 |
Attenuation of ethanol intoxication by alpha-2 adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Alcoholic Intoxication; Animals; Azides; Behavior, Animal; Benzodiazepines; Dioxanes; Ethanol; Idazoxan; Imidazoles; Mice; Receptors, GABA-A; Seizures | 1989 |
Attenuation of hypothermic effects of ethanol by alpha 2-adrenoceptor blockers.
Topics: Adrenergic alpha-Antagonists; Animals; Azides; Benzodiazepines; Body Temperature; Dioxanes; Dose-Response Relationship, Drug; Ethanol; Idazoxan; Imidazoles; Male; Mice; Pentobarbital; Time Factors | 1989 |
Diazepam-insensitive [3H]Ro 15-4513 binding in intact cultured cerebellar granule cells.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Diazepam; Drug Interactions; Rats | 1989 |
Effects of Ro 15-4513 on schedule-controlled responding of pigeons.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Columbidae; Conditioning, Operant; Dose-Response Relationship, Drug; Female; Reinforcement Schedule | 1989 |
Interactions between RO 15-4513 and ethanol on brain self-stimulation and locomotor activity in rats.
Topics: Animals; Azides; Benzodiazepines; Brain; Drug Interactions; Electrodes, Implanted; Ethanol; Male; Motor Activity; Rats; Rats, Inbred Strains; Self Stimulation | 1989 |
Chloride transport in embryonic cells: effect of ethanol and GABA.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Azides; Benzodiazepines; Biological Transport, Active; Bumetanide; Cells, Cultured; Chlorides; Embryo, Mammalian; Ethanol; Extremities; Furosemide; gamma-Aminobutyric Acid; In Vitro Techniques; Mice; Mice, Inbred C57BL | 1989 |
Interactions of diazepam and pentobarbital with RO 15-4513 on intracranial self-stimulation discrimination behavior in rats.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Brain; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Male; Pentobarbital; Rats; Rats, Inbred Strains; Self Stimulation | 1989 |
Effects of Ro 15-4513 on the motor impairment and hypnotic effects of ethanol and pentobarbital.
Topics: Animals; Azides; Benzodiazepines; Ethanol; Hypnotics and Sedatives; Male; Pentobarbital; Psychomotor Performance; Rats; Rats, Inbred Strains | 1989 |
RO15-4513 but not FG-7142 reverses anticonvulsant effects of ethanol against bicuculline- and picrotoxin-induced convulsions in rats.
Topics: Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Bicuculline; Carbolines; Ethanol; Male; Pentobarbital; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
Effects of ethanol and imidazobenzodiazepine Ro 15-4513 on spontaneous saccades of the pigmented rat.
Topics: Animals; Azides; Benzodiazepines; Ethanol; Eye Movements; Female; Male; Rats; Saccades; Time Factors | 1989 |
Effects of the imidazobenzodiazepine Ro 15-4513 on saccharin choice and acceptance, and on food intake, in the rat.
Topics: Animals; Azides; Benzodiazepines; Feeding Behavior; Male; Rats; Saccharin; Taste | 1989 |
Administration of a GABA antagonist selectively attenuates an ethanol-induced conditioned taste aversion.
Topics: Amphetamine; Animals; Avoidance Learning; Azides; Benzodiazepines; Ethanol; GABA Antagonists; Male; Mice; Picrotoxin; Saccharin; Taste | 1989 |
The intrinsic and interactive effects of RO 15-4513 and ethanol on locomotor activity, body temperature, and blood glucose concentration.
Topics: Analysis of Variance; Animals; Azides; Benzodiazepines; Blood Glucose; Body Temperature; Ethanol; Male; Motor Activity; Random Allocation; Rats; Rats, Inbred Strains; Time Factors | 1989 |
Reversal of the intrinsic effects of Ro 15-4513 on exploratory behavior by two benzodiazepine receptor antagonists.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Exploratory Behavior; Flumazenil; Male; Mice; Motor Activity; Receptors, GABA-A | 1987 |
Regional distribution of a Ro5 4864 binding site that is functionally coupled to the gamma-aminobutyric acid/benzodiazepine receptor complex in rat brain.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Benzodiazepinones; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Clonazepam; Male; Photochemistry; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
Effect of intravenously-administered putative and potential antagonists of ethanol on sleep time in ethanol-narcotized mice.
Topics: 4-Aminopyridine; Alcoholic Intoxication; Aminophylline; Aminopyridines; Amphetamine; Animals; Azides; Benzodiazepines; Dextroamphetamine; Doxapram; Ethanol; Male; Mice; Naloxone; Physostigmine; Propranolol; Sleep; Thyrotropin-Releasing Hormone; Yohimbine | 1988 |
Attenuation of the discriminative stimulus properties of ethanol and oxazepam, but not of pentobarbital, by Ro 15-4513 in mice.
Topics: Animals; Azides; Benzodiazepines; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Generalization, Stimulus; Male; Mice; Oxazepam; Phenobarbital; Receptors, GABA-A | 1988 |
Decreased sensitivity to diazepam induced by chronic administration of FG 7142.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Brain Chemistry; Carbolines; Convulsants; Diazepam; Drug Interactions; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
The abstinence syndrome in diazepam-dependent cats is precipitated by Ro 15-1788 and Ro 15-4513 but not by the benzodiazepine receptor antagonist ZK 93426.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cats; Diazepam; Flumazenil; Receptors, GABA-A; Substance Withdrawal Syndrome | 1988 |
Comparison of two different benzodiazepine binding proteins by peptide mapping after limited proteolysis.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Brain Chemistry; Cerebellum; Clonazepam; Flunitrazepam; Hippocampus; Molecular Weight; Peptide Mapping; Rats; Receptors, GABA-A | 1988 |
The imidazobenzodiazepine Ro 15-4513 antagonizes methoxyflurane anesthesia.
Topics: Anesthesia, General; Animals; Azides; Benzodiazepines; Carbolines; Flumazenil; Male; Methoxyflurane; Mice; Receptors, GABA-A; Sleep | 1988 |
Failure of Ro 15-4513 to antagonize ethanol in rat lines selected for differential sensitivity to ethanol and in Wistar rats.
Topics: Animals; Azides; Benzodiazepines; Brain; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Lorazepam; Male; Motor Skills; Rats; Rats, Inbred Strains; Receptors, GABA-A; Species Specificity | 1988 |
RO 15-4513 and FG 7142 reverse the reduction in social behavior caused by ethanol in mice.
Topics: Aggression; Animals; Azides; Benzodiazepines; Carbolines; Ethanol; Male; Mice; Motor Activity; Receptors, GABA-A; Social Behavior | 1988 |
Antagonism of ethanol and pentobarbital actions by benzodiazepine inverse agonists: neurochemical studies.
Topics: Animals; Azides; Benzodiazepines; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbolines; Chloride Channels; Chlorides; Ethanol; Male; Membrane Fluidity; Membrane Proteins; Mice; Mice, Inbred ICR; Pentobarbital; Receptors, GABA-A | 1988 |
Antagonism of ethanol effects on cerebellar Purkinje neurons by the benzodiazepine inverse agonists Ro 15-4513 and FG 7142: electrophysiological studies.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Dose-Response Relationship, Drug; Ethanol; gamma-Aminobutyric Acid; Heart Conduction System; In Vitro Techniques; Male; Membrane Proteins; Purkinje Fibers; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
The benzodiazepine recognition site inverse agonists Ro 15-4513 and FG 7142 both antagonize the EEG effects of ethanol in the rat.
Topics: Animals; Appetite Depressants; Azides; Benzodiazepines; Brain; Carbolines; Electroencephalography; Ethanol; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; Reference Values | 1988 |
Distribution of benzodiazepine receptors in the rat superior colliculus: a light and electron microscope quantitative autoradiographic study.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Receptors, GABA-A; Superior Colliculi | 1988 |
Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [3H]RO15-4513 in rat brain.
Topics: Acoustic Stimulation; Animals; Azides; Benzodiazepines; Body Temperature; Brain Chemistry; Diazepam; Ethanol; Flumazenil; Male; Motor Activity; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures | 1988 |
Ro 15-4513: partial inverse agonism at the BZR and interaction with ethanol.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Brain; Brain Chemistry; Cats; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; Ethanol; Flumazenil; Meta-Analysis as Topic; Mice; Phenobarbital; Rats; Receptors, GABA-A | 1988 |
Antagonizing the anticonvulsant effect of ethanol using drugs acting at the benzodiazepine/GABA receptor complex.
Topics: Animals; Anticonvulsants; Azides; Benzodiazepines; Benzodiazepinones; Carbolines; Convulsants; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Pentobarbital; Receptors, GABA-A; Seizures | 1988 |
Ethanol and the GABA receptor complex: studies with the partial inverse benzodiazepine receptor agonist Ro 15-4513.
Topics: Alcoholic Intoxication; Animals; Azides; Behavior, Animal; Benzodiazepines; Chlorine; Conflict, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Meta-Analysis as Topic; Mice; Pentobarbital; Rats; Receptors, GABA-A; Time Factors | 1988 |
Ethanol potentiates GABA- and glycine-induced chloride currents in chick spinal cord neurons.
Topics: Animals; Azides; Benzodiazepines; Cells, Cultured; Chick Embryo; Chlorides; Ethanol; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Membrane Potentials; Receptors, GABA-A; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord | 1988 |
Does RO 15-4513 reverse the anxiolytic effects of ethanol by its intrinsic properties?
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Choice Behavior; Convulsants; Ethanol; Male; Mice; Motor Activity; Reference Values; Seizures; Stereotyped Behavior | 1988 |
Postnatal development of proteins associated with different benzodiazepine receptors.
Topics: Age Factors; Animals; Azides; Benzodiazepines; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Membrane Proteins; Molecular Weight; Pyridazines; Rats; Receptors, GABA-A | 1986 |
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Chlorides; Ethanol; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes | 1986 |
Photoaffinity labeling of benzodiazepine receptor proteins with the partial inverse agonist [3H]Ro 15-4513: a biochemical and autoradiographic study.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Brain; Carbolines; Cell Membrane; Cerebellum; Flunitrazepam; Hippocampus; Molecular Weight; Photochemistry; Pyridazines; Rats; Receptors, GABA-A | 1987 |
Comparison of tryptic peptides of benzodiazepine binding proteins photolabeled with [3H]flunitrazepam or [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Brain; Cell Membrane; Cerebellum; Flunitrazepam; Hippocampus; Molecular Weight; Peptide Fragments; Photochemistry; Rats; Receptors, GABA-A; Trypsin | 1987 |
Electrophysiological evidence that Ro 15-4513 is a benzodiazepine receptor inverse agonist.
Topics: Animals; Azides; Benzodiazepines; Diazepam; Electrophysiology; Ethanol; In Vitro Techniques; Male; Neurons; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
The effect of the imidazodiazepine Ro 15-4513 on the anticonvulsant effects of diazepam, sodium pentobarbital and ethanol.
Topics: Animals; Azides; Benzodiazepines; Convulsants; Diazepam; Ethanol; Ligands; Male; Mice; Pentobarbital; Receptors, GABA-A | 1987 |
The benzodiazepine receptor inverse agonists FG 7142 and RO 15-4513 both reverse some of the behavioral effects of ethanol in a holeboard test.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Ethanol; Exploratory Behavior; Male; Mice; Motor Activity; Receptors, GABA-A | 1987 |
Alcohol antagonists--the continuing quest.
Topics: Alcohol Deterrents; Animals; Azides; Benzodiazepines; Brain; Ethanol | 1988 |
Interaction of RO 15-4513 and ethanol on the behaviour of mice: antagonistic or additive effects?
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Choice Behavior; Drug Interactions; Ethanol; Hypnotics and Sedatives; Male; Mice; Motor Activity | 1988 |
Reversal of alcohol-induced amnesia by the benzodiazepine inverse agonist Ro 15-4513.
Topics: Amnesia; Animals; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Mice; Time Factors | 1988 |
Ethanol suppression of schedule-controlled responding: interactions with Ro 15-4513, Ro 15-1788 and CGS 8216.
Topics: Alcohol Deterrents; Animals; Azides; Behavior, Animal; Benzodiazepines; Drug Interactions; Ethanol; Flumazenil; Male; Pyrazoles; Rats; Rats, Inbred Strains | 1988 |
Effects of Ro 15-4513, alone or in combination with ethanol, Ro 15-1788, diazepam, and pentobarbital on instrumental behaviors of rats.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Female; Flumazenil; Pentobarbital; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Ro 15-4513, like anxiogenic beta-carbolines, increases dopamine metabolism in the prefrontal cortex of the rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Affinity Labels; Animals; Appetite Depressants; Azides; Benzodiazepines; Carbolines; Cerebral Cortex; Dopamine; Male; Rats; Rats, Inbred Strains | 1988 |
Interactions of three benzodiazepine receptor inverse agonists with ethanol in a plus-maze test of anxiety.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Ethanol; Exploratory Behavior; Learning; Male; Mice; Mice, Inbred Strains; Motor Activity; Reference Values | 1988 |
Ethanol and Ro 15-4513: behaviour maintained by operant procedures (DRL-72s and PTZ-drug discrimination) in rats.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Generalization, Stimulus; Male; Mental Recall; Pentylenetetrazole; Rats; Rats, Inbred Strains; Reinforcement Schedule | 1988 |
The effects of Ro 15-4513 on the behavioral actions of ethanol in an operant reaction time task and a conflict test.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Dose-Response Relationship, Drug; Ethanol; Male; Motor Activity; Pentobarbital; Rats; Rats, Inbred Strains; Reaction Time | 1988 |
Failure of the partial inverse benzodiazepine agonist Ro15-4513 to block the lethal effects of ethanol in rats.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains | 1988 |
Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Azides; Benzodiazepines; Desipramine; Drinking Behavior; Feeding Behavior; Fluoxetine; Male; Rats; Reference Values; Species Specificity | 1988 |
A specific antagonist of ethanol: clinical implications.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Ethanol; Rats | 1987 |
Is ethanol antagonist Ro15-4513 selective for ethanol?
Topics: Animals; Azides; Benzodiazepines; Brain; Conditioning, Psychological; Electroshock; Ethanol; Rats | 1988 |
Interactions of the imidazodiazepine Ro 15-4513 with chemical convulsants.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Bicuculline; Carbolines; Convulsants; Drug Interactions; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures | 1988 |
Antagonist action of imidazobenzodiazepine Ro 15-4513 on ethanol-induced alterations of saccadic eye movements in the pigmented rat.
Topics: Animals; Azides; Benzodiazepines; Drug Interactions; Ethanol; Eye Movements; Female; Injections, Intraperitoneal; Male; Rats; Saccades; Time Factors | 1988 |
RO 15-4513 does not protect rats against the lethal effects of ethanol.
Topics: Animals; Azides; Benzodiazepines; Ethanol; Male; Postural Balance; Rats; Rats, Inbred Strains; Reflex; Time Factors | 1988 |
Protection against ethanol mortality in rats by the imidazobenzodiazepine RO 15-4513.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Male; Rats; Rats, Inbred Strains | 1987 |
Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital.
Topics: Animals; Azides; Benzodiazepines; Body Temperature Regulation; Ethanol; Hypothermia; Kinetics; Male; Mice; Mice, Inbred C57BL; Pentobarbital; Time Factors | 1987 |
Oral ethanol reinforcement in the rat: effect of the partial inverse benzodiazepine agonist RO15-4513.
Topics: Administration, Oral; Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Ethanol; Male; Rats; Reinforcement, Psychology; Self Administration | 1987 |
Interactions of Ro 15-4513 with diazepam, sodium pentobarbital and ethanol in a holeboard test.
Topics: Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; Exploratory Behavior; Head; Male; Mice; Motor Activity; Pentobarbital; Posture | 1987 |
Ethanol prevents stress-induced increase in cortical DOPAC: reversal by RO 15-4513.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Azides; Benzodiazepines; Diazepam; Electroshock; Ethanol; Male; Phenylacetates; Rats; Stress, Physiological | 1987 |
Anxiety-like subjective effect of ethanol antagonist RO 15-4513 demonstrated in pentylenetetrazol discrimination.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Diazepam; Discrimination, Psychological; Male; Pentylenetetrazole; Rats | 1987 |
Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia.
Topics: Animals; Azides; Benzodiazepines; Body Temperature; Ethanol; Hypnotics and Sedatives; Hypothermia; Male; Mice; Mice, Inbred C57BL; Sleep; Time Factors | 1987 |
New drug counters alcohol intoxication.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Ethanol; Humans; Rats | 1986 |
Seizures in drug-treated animals.
Topics: Animals; Azides; Benzodiazepines; Male; Rats; Rats, Inbred Strains; Saimiri; Seizures | 1987 |
Photoaffinity labeling of benzodiazepine receptors with a partial inverse agonist.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; In Vitro Techniques; Photochemistry; Rats; Receptors, GABA-A | 1984 |
Contribution of "diazepam-insensitive" GABAA receptors to the alcohol antagonist properties of Ro 15-4513 and related imidazobenzodiazepines.
Topics: Alcohol Deterrents; Animals; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Cerebellum; Diazepam; Dose-Response Relationship, Drug; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred Strains | 1995 |
Antagonism by intracerebellar Ro15-4513 of acute ethanol-induced motor incoordination in mice.
Topics: Animals; Ataxia; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebellum; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Microinjections; Motor Activity; Postural Balance | 1995 |
Involvement of benzodiazepine/GABA-A receptor complex in ethanol-induced state-dependent learning in rats.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Bicuculline; Diazepam; Ethanol; Evaluation Studies as Topic; Flumazenil; Male; Muscimol; Picrotoxin; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A | 1995 |
Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied gamma-aminobutyric acid.
Topics: Action Potentials; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebellum; Drug Synergism; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Iontophoresis; Purkinje Cells; Rats; Rats, Sprague-Dawley | 1995 |
Effects of systemic and local ethanol on responses of rat cerebellar Purkinje neurons to iontophoretically applied norepinephrine and gamma-aminobutyric acid.
Topics: Action Potentials; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebellum; Drug Synergism; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Iontophoresis; Male; Norepinephrine; Purkinje Cells; Rats; Rats, Sprague-Dawley; Sympathomimetics | 1995 |
Binding of 1,4-benzodiazepines to a novel [3H]Ro15-4513 binding site in the rat spinal cord.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Cloning, Molecular; Imidazoles; In Vitro Techniques; Ligands; Membranes; Pyridines; Radioligand Assay; Rats; Receptors, GABA-A; Spinal Cord | 1995 |
Chloride channel expression with the tandem construct of alpha 6-beta 2 GABAA receptor subunit requires a monomeric subunit of alpha 6 or gamma 2.
Topics: Affinity Labels; Azides; Base Sequence; Benzodiazepines; Binding Sites; Blotting, Northern; Cell Line; Chloride Channels; DNA, Complementary; gamma-Aminobutyric Acid; Gene Expression; Humans; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Molecular Sequence Data; Muscimol; Oligodeoxyribonucleotides; Protein Multimerization; Receptors, GABA-A; Recombinant Proteins | 1995 |
Phenotypic and genotypic analysis of rats with cerebellar GABAA receptors composed from mutant and wild-type alpha 6 subunits.
Topics: Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Diazepam; Genotype; Heterozygote; Molecular Probes; Molecular Sequence Data; Mutation; Phenotype; Rats; Receptors, GABA-A; Recombinant Proteins | 1995 |
Modulation of recombinant alpha 6 beta 2 gamma 2 GABAA receptors by neuroactive steroids.
Topics: Azides; Benzodiazepines; Binding, Competitive; Cell Line; Cells, Cultured; Electrophysiology; gamma-Aminobutyric Acid; Muscimol; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins; Steroids | 1995 |
Characterization of novel ligands for wild-type and natural mutant diazepam-insensitive benzodiazepine receptors.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Cerebellum; Diazepam; Ethanol; Male; Mutation; Rats; Rats, Wistar; Receptors, GABA-A | 1995 |
Antagonism of ethanol by pretreatment or posttreatment with RO 15-4513 and indomethacin alone or in combination.
Topics: Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Brain; Chloride Channels; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Indomethacin; Male; Mice; Mice, Inbred DBA; Postural Balance; Premedication; Receptors, GABA; Reflex | 1995 |
Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Arginine; Autoradiography; Azides; Base Sequence; Benzodiazepines; Binding, Competitive; Cerebellum; Diazepam; Drug Tolerance; Ethanol; gamma-Aminobutyric Acid; Histidine; In Situ Hybridization; Kinetics; Macromolecular Substances; Models, Structural; Molecular Sequence Data; Motor Activity; Oligodeoxyribonucleotides; Point Mutation; Poly A; Protein Structure, Secondary; Rats; Rats, Mutant Strains; Receptors, GABA-A; RNA; RNA, Messenger; Tritium | 1993 |
Effect of Ro 15-4513 and nifedipine on the behaviour and potassium-evoked calcium uptake following withdrawal from chronic ethanol administration in rats.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Calcium; Calcium Channels; Cerebral Cortex; Ethanol; Ion Transport; Male; Nifedipine; Potassium; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Synaptosomes | 1993 |
Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Diazepam; Male; Molecular Probes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship | 1995 |
The effects of drugs acting at GABA-benzodiazepine-barbiturate receptor complex on the behaviour of sleep-deprived mice.
Topics: Analysis of Variance; Animals; Azides; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Flumazenil; Male; Mice; Receptors, GABA-A; Sleep Deprivation | 1995 |
Four amino acid exchanges convert a diazepam-insensitive, inverse agonist-preferring GABAA receptor into a diazepam-preferring GABAA receptor.
Topics: Amino Acid Sequence; Azides; Base Sequence; Benzodiazepines; Binding Sites; Diazepam; GABA Agonists; Humans; Molecular Sequence Data; Mutation; Receptors, GABA-A; Structure-Activity Relationship | 1994 |
Benzodiazepine receptor ligands modulate ethanol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Animals; Anti-Anxiety Agents; Azepines; Azides; Benzodiazepines; Benzodiazepinones; Body Weight; Drug Administration Schedule; Eating; Food Preferences; Injections, Intraperitoneal; Ligands; Male; Naloxone; Pyrazoles; Rats; Receptors, GABA-A | 1994 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Carbamazepine; Convulsants; Drug Tolerance; Electric Stimulation; Electroencephalography; Flunitrazepam; Functional Laterality; Gene Expression; Hippocampus; In Situ Hybridization; Kindling, Neurologic; Macromolecular Substances; Muscimol; Neurons; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Seizures; Tritium | 1994 |
"Anxiolytic" and "anxiogenic" benzodiazepines and beta-carbolines: effects on aggressive and social behavior in rats and squirrel monkeys.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Motor Activity; Rats; Saimiri; Social Behavior; Species Specificity | 1993 |
Ethanol self-administration in freely feeding and drinking rats: effects of Ro15-4513 alone, and in combination with Ro15-1788 (flumazenil).
Topics: Alcohol Drinking; Animals; Azides; Benzodiazepines; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flumazenil; GABA-A Receptor Agonists; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology | 1994 |
Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: opposite effects of FG 7142 and lorazepam.
Topics: Animals; Appetite Depressants; Attention; Azides; Benzodiazepines; Carbolines; Conditioning, Operant; GABA-A Receptor Antagonists; Ligands; Lorazepam; Male; Motor Activity; Rats; Rats, Wistar; Receptors, GABA-A | 1994 |
Interactions of Ro15-4513, Ro15-1788 (flumazenil) and ethanol on measures of exploration and locomotion in rats.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Environment; Ethanol; Exploratory Behavior; Flumazenil; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1994 |
Different functional effect of Ro 15-4513 and Ro 19-4603 on synaptic responses of Purkinje cells in the rat cerebellar slice.
Topics: Animals; Azepines; Azides; Benzodiazepines; Cerebellum; Diazepam; Electrophysiology; Flumazenil; In Vitro Techniques; Male; Neural Inhibition; Purkinje Cells; Rats; Rats, Wistar; Receptors, GABA-A; Synapses | 1994 |
F 2692: flumazenil-reversible anxiolytic effects but inactive on [3H]-Ro 15-4513 binding.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding, Competitive; Carbolines; Cerebellum; Diazepam; Flumazenil; GABA-A Receptor Antagonists; In Vitro Techniques; Interpersonal Relations; Male; Membranes; Motor Activity; Pyridazines; Rats; Receptors, GABA-A | 1994 |
Development pattern of the GABAA-benzodiazepine receptor ionophore complex in primary cultures of cortical neurons.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Chlorides; Flumazenil; Flunitrazepam; Mice; Mice, Inbred C57BL; Muscimol; Neurons; Receptors, GABA-A | 1994 |
Intrastriatal Ro15-4513 functionally antagonizes ethanol-induced motor incoordination and striatal adenosinergic modulation of ethanol-induced motor incoordination in rats.
Topics: Adenosine; Animals; Ataxia; Azides; Benzodiazepines; Corpus Striatum; Dose-Response Relationship, Drug; Ethanol; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA | 1994 |
Inhibition and inactivation of horse liver alcohol dehydrogenase with the imidazobenzodiazepine Ro 15-4513.
Topics: Affinity Labels; Alcohol Dehydrogenase; Animals; Azides; Benzodiazepines; Flumazenil; Horses; Hydrogen-Ion Concentration; Kinetics; Liver; Mathematics; Molecular Structure; NAD | 1994 |
Differential interactions between ethanol and Ro 15-4513 on two anxiety tests in rats.
Topics: Animals; Anxiety; Avoidance Learning; Azides; Benzodiazepines; Ethanol; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1994 |
GABAA receptor subtypes expressed in cerebellar granule cells: a developmental study.
Topics: Aging; Animals; Animals, Newborn; Azides; Benzodiazepines; Cell Membrane; Cells, Cultured; Cerebellum; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Immunohistochemistry; Macromolecular Substances; Neurons; Receptors, GABA-A | 1994 |
Characterization of diazepam-insensitive [3H]Ro 15-4513 binding in rodent brain and cultured cerebellar neuronal cells.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cells, Cultured; Cerebellum; Cerebral Cortex; Diazepam; Guinea Pigs; Hippocampus; Kinetics; Male; Mice; Mice, Inbred Strains; Neurons; Olfactory Bulb; Organ Specificity; Rats; Rats, Wistar; Receptors, GABA-A; Species Specificity; Tritium | 1994 |
Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors.
Topics: Azides; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Humans; Kinetics; Ligands; Peptide Fragments; Radioligand Assay; Receptors, GABA-A | 1994 |
Model of subunit composition of gamma-aminobutyric acid A receptor subtypes expressed in rat cerebellum with respect to their alpha and gamma/delta subunits.
Topics: Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Escherichia coli; Flumazenil; Molecular Sequence Data; Muscimol; Precipitin Tests; Protein Conformation; Rats; Receptors, GABA-A; Recombinant Proteins | 1994 |
Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment.
Topics: Animals; Avoidance Learning; Azides; Benzodiazepines; Chlordiazepoxide; Conflict, Psychological; Dose-Response Relationship, Drug; Ethanol; Flumazenil; Male; Postural Balance; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 1993 |
Natural mutation of GABAA receptor alpha 6 subunit alters benzodiazepine affinity but not allosteric GABA effects.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cerebellum; Cloning, Molecular; Convulsants; Diazepam; gamma-Aminobutyric Acid; Granulocytes; Humans; Kidney; Muscimol; Mutation; Picrotoxin; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection | 1993 |
No age-related changes in human benzodiazepine receptor binding measured by PET with [11C]Ro 15-4513.
Topics: Adult; Affinity Labels; Aged; Aging; Azides; Benzodiazepines; Brain; Humans; Male; Middle Aged; Receptors, GABA-A; Tomography, Emission-Computed | 1993 |
Effects of benzodiazepine agonist, antagonist and inverse agonist on ethanol-induced changes in beta-endorphin levels in specific rat brain regions.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; beta-Endorphin; Brain Chemistry; Cerebral Cortex; Diazepam; Ethanol; Flumazenil; Hippocampus; Hypothalamus; Male; Rats; Rats, Sprague-Dawley | 1993 |
Prevention of ethanol-induced gastric damage by the imidazobenzodiazepines Ro 15-4513 and Ro 15-3505 in rats.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Ethanol; Flumazenil; Male; Rats; Rats, Wistar; Stomach Ulcer | 1993 |
Hepatic encephalopathy in rats with thioacetamide-induced acute liver failure is not mediated by endogenous benzodiazepines.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Convulsants; Flunitrazepam; Hepatic Encephalopathy; Liver Failure, Acute; Male; Rats; Rats, Sprague-Dawley; Thioacetamide | 1993 |
Further evidence for the existence of alpha subunit heterogeneity within discrete gamma-aminobutyric acidA receptor subpopulations.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Cattle; Cerebellum; Cerebral Cortex; Chromatography, Affinity; Cysteine; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Immunoblotting; Macromolecular Substances; Molecular Weight; Receptors, GABA-A | 1993 |
Early postnatal treatment with muscimol transiently alters brain GABAA receptors and open-field behavior in rat.
Topics: Aging; Animals; Animals, Newborn; Azides; Behavior, Animal; Benzodiazepines; Brain Chemistry; Ethanol; Flunitrazepam; Male; Muscimol; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Weight Gain | 1993 |
GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol.
Topics: Alcohol Drinking; Animals; Appetitive Behavior; Arousal; Azides; Benzodiazepines; Brain; Chlordiazepoxide; Conditioning, Operant; Convulsants; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Male; Motivation; Organophosphorus Compounds; Rats; Rats, Wistar; Receptors, GABA-A; Self Administration | 1993 |
Development of tolerance to anxiolytic effects of chlordiazepoxide in elevated plus-maze test and decrease of GABAA receptors.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain Chemistry; Chlordiazepoxide; Down-Regulation; Drug Tolerance; Exploratory Behavior; Flunitrazepam; Male; Mice; Receptors, GABA-A | 1993 |
Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Bicuculline; Diet; Dose-Response Relationship, Drug; Ethanol; GABA-A Receptor Antagonists; Injections, Intraventricular; Male; Rats; Rats, Wistar; Receptors, GABA-A; Reinforcement Schedule; Substance Withdrawal Syndrome | 1993 |
Postnatal development of diazepam-insensitive [3H]Ro 15-4513 binding sites.
Topics: Affinity Labels; Aging; Animals; Autoradiography; Azides; Benzodiazepines; Brain; Brain Chemistry; Cerebellum; Cerebral Cortex; Diazepam; Hippocampus; Kinetics; Membranes; Photochemistry; Rats; Rats, Wistar; Receptors, GABA-A; Ultraviolet Rays | 1993 |
Benzodiazepine receptor ligands are elevated in an animal model of hepatic encephalopathy: relationship between brain concentration and severity of encephalopathy.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Disease Models, Animal; GABA-A Receptor Antagonists; Hepatic Encephalopathy; Ligands; Male; Motor Activity; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 1993 |
Cloning of cDNA sequences encoding human alpha 2 and alpha 3 gamma-aminobutyric acidA receptor subunits and characterization of the benzodiazepine pharmacology of recombinant alpha 1-, alpha 2-, alpha 3-, and alpha 5-containing human gamma-aminobutyric ac
Topics: Amino Acid Sequence; Azides; Base Sequence; Benzodiazepines; Binding Sites; Cell Line; Cloning, Molecular; DNA; Humans; Molecular Sequence Data; Receptors, GABA-A; Recombinant Proteins; Sequence Alignment; Transfection | 1993 |
The human neuroblastoma cell line, IMR-32 possesses a GABAA receptor lacking the benzodiazepine modulatory site.
Topics: Animals; Azides; Benzodiazepines; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Chloride Channels; Flunitrazepam; Humans; Kinetics; Membrane Proteins; Neuroblastoma; Radioligand Assay; Rats; Receptors, GABA-A; Tumor Cells, Cultured | 1993 |
The benzodiazepine receptor partial agonist bretazenil and the partial inverse agonist Ro 15-4513: effects on salt preference and aversion in the rat.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Flumazenil; Food Preferences; Male; Rats; Receptors, GABA-A; Saline Solution, Hypertonic; Sodium Chloride; Taste | 1993 |
Benzodiazepine binding to GABAA receptors: differential effects of sulfhydryl modification.
Topics: Animals; Azides; Benzodiazepines; Cattle; Cerebral Cortex; Disulfides; Dithiothreitol; Ethylmaleimide; Flunitrazepam; In Vitro Techniques; Kinetics; Membranes; Muscimol; Radioligand Assay; Receptors, GABA-A; Sulfhydryl Compounds | 1993 |
Ro 15-4513 selectively attenuates ethanol, but not sucrose, reinforced responding in a concurrent access procedure; comparison to other drugs.
Topics: Animals; Azides; Benzodiazepines; Chlordiazepoxide; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Male; Morphine; Naloxone; Rats; Rats, Wistar; Reinforcement, Psychology; Sucrose; Time Factors | 1995 |
The alpha 1 and alpha 6 subunits can coexist in the same cerebellar GABAA receptor maintaining their individual benzodiazepine-binding specificities.
Topics: Amino Acid Sequence; Animals; Azides; Benzodiazepines; Cerebellum; Immune Sera; Immunoblotting; Immunohistochemistry; Membranes; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution | 1996 |
Bidirectional regulation of GABAA receptor alpha1 and alpha6 subunit expression by a cyclic AMP-mediated signalling mechanism in cerebellar granule cells in primary culture.
Topics: 1-Methyl-3-isobutylxanthine; Affinity Labels; Animals; Azides; Benzodiazepines; Bucladesine; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Neurons; Phosphodiesterase Inhibitors; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Signal Transduction; Tritium | 1996 |
Cloning and characterization of the human GABAA receptor alpha 4 subunit: identification of a unique diazepam-insensitive binding site.
Topics: Amino Acid Sequence; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Humans; Molecular Sequence Data; Receptors, GABA-A; Recombinant Proteins; Sequence Homology, Amino Acid | 1995 |
Chronic ethanol exposure selectively increases diazepam-insensitive [3H]RO15-4513 binding in mouse cerebellum.
Topics: Administration, Inhalation; Analysis of Variance; Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Cerebral Cortex; Diazepam; Ethanol; GABA Modulators; Male; Mice; Mice, Inbred C3H | 1996 |
Differences in benzodiazepine binding in quail selectively bred for differences in tonic immobility.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Brain; Chlorine; Coturnix; Diazepam; Ethanol; Flunitrazepam; gamma-Aminobutyric Acid; Kinetics; Motor Activity; Radioisotopes; Receptors, GABA-A | 1996 |
Effects of ethanol in a putative rodent model of tardive dyskinesia.
Topics: Affinity Labels; Animals; Antipsychotic Agents; Azides; Behavior, Animal; Benzodiazepines; Central Nervous System Depressants; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Ethanol; Fluphenazine; Grooming; Male; Motor Activity; Movement; Rats; Rats, Sprague-Dawley | 1996 |
Chronic pentobarbital administration alters gamma-aminobutyric acidA receptor alpha 6-subunit mRNA levels and diazepam-insensitive [3H]Ro15-4513 binding.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Binding, Competitive; Diazepam; In Situ Hybridization; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger | 1996 |
Characterization of a benzodiazepine receptor site with exceptionally high affinity for Ro 15-4513 in the rat CNS.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Central Nervous System; Cerebellum; Chlorides; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; GABA Modulators; Hippocampus; Imidazoles; Male; Pyridines; Rats; Rats, Wistar; Receptors, GABA-A; Spinal Cord; Tritium | 1995 |
Affinity of various ligands for GABAA receptors containing alpha 4 beta 3 gamma 2, alpha 4 gamma 2, or alpha 1 beta 3 gamma 2 subunits.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cloning, Molecular; Embryo, Mammalian; Humans; In Vitro Techniques; Kidney; Ligands; Protein Binding; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Structure-Activity Relationship | 1996 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepines; Carbolines; Catecholamines; Corticosterone; Diazepam; Disease Models, Animal; Female; GABA-A Receptor Agonists; Glucocorticoids; Immunity, Cellular; Immunity, Innate; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mifepristone; Nadolol; Naltrexone; Neurosecretory Systems; Oxidopamine; Phentolamine; Picrotoxin; Propranolol; Receptors, GABA-A; Spleen; Sympathetic Nervous System | 1996 |
Mapping of GABAA receptor sites that are photoaffinity-labelled by [3H]flunitrazepam and [3H]Ro 15-4513.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain Chemistry; Brain Mapping; Cattle; Cerebellum; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; Hydrogen-Ion Concentration; Hydroxylamines; In Vitro Techniques; Molecular Weight; Radioligand Assay; Receptors, GABA-A | 1996 |
Effects of the benzodiazepine receptor inverse agonist Ro 15-4513 on the ingestion of sucrose and sodium saccharin solutions: a microstructural analysis of licking behavior.
Topics: Animals; Azides; Benzodiazepines; Feeding Behavior; GABA-A Receptor Antagonists; Male; Rats; Saccharin; Sucrose | 1996 |
Inhibition of GABAA ligand-gated Cl- channels by zinc in adult rat brain: a regional study.
Topics: Animals; Azides; Benzodiazepines; Brain; Cerebellum; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Hippocampus; Ion Channel Gating; Kinetics; Male; Muscimol; Organ Specificity; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Synaptosomes; Tritium; Zinc | 1996 |
Pharmacodynamic response to Ro15-4513 in ethanol intoxicated dogs.
Topics: Acetaldehyde; Alcoholic Intoxication; Animals; Azides; Benzodiazepines; Biotransformation; Blood Pressure; Central Nervous System Depressants; Dogs; Ethanol; Heart Rate; Inactivation, Metabolic | 1996 |
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Carbolines; Diazepam; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Imidazoles; Kinetics; Membrane Potentials; Radioligand Assay; Rats; Receptors, GABA-A; Recombinant Proteins; Sensitivity and Specificity; Zinc | 1996 |
Visual evoked potentials and nitrous oxide-induced neuronal depression: role for benzodiazepine receptors.
Topics: Anesthetics, Inhalation; Animals; Azides; Benzodiazepines; Evoked Potentials, Visual; Male; Neurons; Nitrous Oxide; Rats; Rats, Wistar; Receptors, GABA-A | 1996 |
Ro 15-4513 alteration of pentobarbital dependence.
Topics: Animals; Azides; Benzodiazepines; Dose-Response Relationship, Drug; Drug Interactions; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors; Weight Loss | 1996 |
GABAA and NMDA receptor subunit mRNA expression in ethanol dependent rats.
Topics: Alcoholism; Animals; Azides; Base Sequence; Benzodiazepines; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; DNA, Complementary; Gene Expression; Hippocampus; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Seizures; Substance Withdrawal Syndrome; Zolpidem | 1994 |
Bidirectional modulation of sweet and bitter taste by chlordiazepoxide and Ro 15-4513: lack of effect with GABA drugs.
Topics: Animals; Appetitive Behavior; Azides; Benzodiazepines; Brain; Chlordiazepoxide; Dietary Sucrose; Food Preferences; GABA Modulators; Male; Quinine; Rats; Rats, Wistar; Receptors, GABA-A; Taste; Taste Threshold | 1997 |
Ro 15-4513 potentiates, instead of antagonizes, ethanol-induced sleep in mice exposed to small platform stress.
Topics: Animals; Anxiety; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebellum; Chlorides; Diazepam; Drug Synergism; Ethanol; GABA Agonists; GABA Modulators; Male; Mice; Muscimol; Receptors, GABA-A; Sleep; Stress, Psychological | 1996 |
Identification of domains in human recombinant GABAA receptors that are photoaffinity labelled by [3H]flunitrazepam and [3H]Ro15-4513.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Flunitrazepam; GABA Agonists; GABA Modulators; Humans; Hydroxylamines; Membranes; Mice; Radioligand Assay; Receptors, GABA-A; Recombinant Proteins | 1996 |
Extensive heterogeneity of recombinant gamma-aminobutyric acidA receptors expressed in alpha 4 beta 3 gamma 2-transfected human embryonic kidney 293 cells.
Topics: Affinity Labels; Azides; Benzodiazepines; Blotting, Western; Cell Line; GABA Agonists; Humans; Kidney; Kinetics; Muscimol; Receptors, GABA-A; Recombinant Proteins; Transfection | 1996 |
A subclass of GABAA/benzodiazepine receptor exclusively localized in the limbic system.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Carbon Radioisotopes; Female; Flumazenil; GABA Modulators; Image Processing, Computer-Assisted; Isotope Labeling; Limbic System; Macaca mulatta; Receptors, GABA-A; Tomography, Emission-Computed | 1996 |
Protection against cocaine and combined cocaine-ethanol toxicities in mice by imidazobenzodiazepine Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cocaine; Drug Combinations; Drug Synergism; Ethanol; Injections, Intraperitoneal; Liver; Male; Mice; Mice, Inbred ICR; Mortality; Narcotic Antagonists; Narcotics; Receptors, GABA-A; Seizures; Survival Analysis; Survival Rate | 1997 |
Discriminative stimulus effects of flumazenil in rhesus monkeys treated chronically with chlordiazepoxide.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Azides; Benzodiazepines; Chlordiazepoxide; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Antagonists; Macaca mulatta; Pharmaceutical Vehicles; Time Factors | 1997 |
Flunitrazepam has an inverse agonistic effect on recombinant alpha6beta2gamma2-GABAA receptors via a flunitrazepam-binding site.
Topics: Affinity Labels; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Cell Line; Chloride Channels; Flunitrazepam; GABA Agonists; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Humans; Kidney; Kinetics; Macromolecular Substances; Membrane Potentials; Receptors, GABA-A; Recombinant Proteins; Transfection | 1997 |
The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Chloride Channels; Conflict, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Organophosphorus Compounds; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A | 1997 |
The effects of flumazenil, Ro 15-4513 and beta-CCM on the behaviour of control and stressed mice in the plus-maze test.
Topics: Animals; Anxiety; Azides; Behavior, Animal; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; Ligands; Male; Mice; Stress, Psychological | 1997 |
GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Brain; Cell Membrane; Cerebellum; Diazepam; Flumazenil; Immunohistochemistry; Immunosorbent Techniques; Macromolecular Substances; Male; Muscimol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins | 1997 |
Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Convulsants; Diazepam; Diuretics; Furosemide; GABA Agonists; GABA Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Mice; Mice, Inbred C57BL; Mutation; Pregnanolone; Pyridazines; Receptors, GABA-A; Sulfur Radioisotopes; Tritium; Zinc | 1997 |
Diazepam-sensitive GABA(A) receptors in the NTS participate in cardiovascular control.
Topics: Affinity Labels; Animals; Anti-Anxiety Agents; Autonomic Nervous System; Autoradiography; Azides; Benzodiazepines; Blood Pressure; Brain; Diazepam; Drug Synergism; GABA Agonists; Heart Rate; Isonicotinic Acids; Male; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Solitary Nucleus; Tritium | 1997 |
Opposite effects of Ro 15-4513 on acquisition and maintenance of ethanol drinking behavior in male Wistar rats.
Topics: Alcohol Drinking; Animals; Azides; Behavior, Animal; Benzodiazepines; Conditioning, Operant; Drinking Behavior; Ethanol; Interpersonal Relations; Male; Rats; Rats, Wistar; Self Administration; Water | 1997 |
The striatal adenosinergic modulation of ethanol-induced motor incoordination in rats: possible role of chloride flux.
Topics: Adenosine; Affinity Labels; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Cerebrospinal Fluid; Chlorides; Corpus Striatum; Ethanol; GABA Modulators; Male; Microdialysis; Motor Activity; Pentobarbital; Radioisotopes; Rats; Rats, Sprague-Dawley; Xanthines | 1997 |
Localization and pharmacological characterization of pigeon diazepam-insensitive GABAA receptors.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Columbidae; Diazepam; GABA Modulators; gamma-Aminobutyric Acid; Ligands; Male; Radioligand Assay; Receptors, GABA-A | 1997 |
Subunit composition and quantitative importance of hetero-oligomeric receptors: GABAA receptors containing alpha6 subunits.
Topics: Affinity Labels; Animals; Antibodies; Azides; Benzodiazepines; Cell Extracts; Cells, Cultured; Cerebellum; Cloning, Molecular; GABA Agonists; Humans; Kidney; Muscimol; Precipitin Tests; Radioimmunoassay; Rats; Receptors, GABA-A; Tritium | 1998 |
Effects of propofol and pentobarbital on ligand binding to GABAA receptors suggest a similar mechanism of action.
Topics: Allosteric Site; Anesthetics, Intravenous; Animals; Azides; Benzodiazepines; Brain; Cattle; Flunitrazepam; GABA Agonists; In Vitro Techniques; Ligands; Membranes; Muscimol; Pentobarbital; Propofol; Receptors, GABA-A | 1998 |
Structural requirements for ligand interactions at the benzodiazepine recognition site of the GABA(A) receptor.
Topics: Allosteric Site; Animals; Azides; Benzodiazepines; Carbolines; Cell Line; Flunitrazepam; GABA Modulators; Ligands; Mutation; Rats; Receptors, GABA-A | 1998 |
GABA(A) receptor alpha4 subunit suppression prevents withdrawal properties of an endogenous steroid.
Topics: Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Carbolines; Female; gamma-Aminobutyric Acid; Hippocampus; Indomethacin; Lorazepam; Oligonucleotides, Antisense; Patch-Clamp Techniques; Pregnanolone; Premenstrual Syndrome; Progesterone; Pyramidal Cells; Rats; Receptors, GABA-A; RNA, Messenger; Transcription, Genetic | 1998 |
Effects of benzodiazepine receptor ligands on the ingestion of sucrose, intralipid, and maltodextrin: an investigation using a microstructural analysis of licking behavior in a brief contact test.
Topics: Analysis of Variance; Animals; Azides; Benzodiazepines; Drinking; Fat Emulsions, Intravenous; GABA Agents; Male; Midazolam; Polysaccharides; Rats; Rats, Inbred Strains; Reaction Time; Receptors, GABA-A; Solutions; Sucrose; Taste; Time Factors | 1998 |
Effects of buprenorphine and Ro 15-4513 on delayed death and brain beta-endorphin levels in rats treated with cocaine or cocaine-ethanol.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; beta-Endorphin; Brain Chemistry; Buprenorphine; Central Nervous System Depressants; Cocaine; Dopamine Uptake Inhibitors; Ethanol; Male; Narcotic Antagonists; Rats; Rats, Wistar; Stress, Physiological | 1998 |
Identification of a unique domain in bovine brain GABAA receptors that is photoaffinity labelled by [3H]Ro15-4513.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cattle; Nerve Tissue Proteins; Receptors, GABA-A | 1998 |
GABAA-benzodiazepine receptors in the striatum are involved in the sedation produced by a moderate, but not an intoxicating ethanol dose in outbred Wistar rats.
Topics: Alcoholic Intoxication; Analysis of Variance; Animals; Azides; Benzodiazepines; Corpus Striatum; Ethanol; Flumazenil; GABA Agents; GABA-A Receptor Agonists; Hypnotics and Sedatives; Male; Oocytes; Pyridazines; Rats; Rats, Wistar; Receptors, GABA-A; Xenopus | 1998 |
Photoaffinity labeling of the benzodiazepine binding site of alpha1beta3gamma2 gamma-aminobutyric acidA receptors with flunitrazepam identifies a subset of ligands that interact directly with His102 of the alpha subunit and predicts orientation of these w
Topics: Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Flunitrazepam; GABA Modulators; Humans; Ligands; Models, Molecular; Photoaffinity Labels; Receptors, GABA-A; Structure-Activity Relationship; Ultraviolet Rays | 1998 |
Imaging of the super high affinity binding sites for [3H]Ro15-4513 in rat hippocampus: comparison between in vitro and in vivo binding.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Brain Chemistry; Hippocampus; In Vitro Techniques; Male; Radionuclide Imaging; Rats; Rats, Wistar; Tritium | 1998 |
Pharmacology of recombinant gamma-aminobutyric acidA receptors rendered diazepam-insensitive by point-mutated alpha-subunits.
Topics: Amino Acid Sequence; Animals; Azides; Base Sequence; Benzodiazepines; Benzodiazepinones; Cell Line; Diazepam; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Recombinant Proteins | 1998 |
Decreased expression of GABAA receptor alpha6 and beta3 subunits in stargazer mutant mice: a possible role for brain-derived neurotrophic factor in the regulation of cerebellar GABAA receptor expression?
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain-Derived Neurotrophic Factor; Cell Membrane; Cerebellum; Gene Expression Regulation; Genes, Recessive; Macromolecular Substances; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Neurons; Radioligand Assay; Receptors, GABA-A; Tritium | 1998 |
Ethanol-induced activation of the hypothalamic-pituitary-adrenal axis in a mouse model for binge drinking: role of Ro15-4513-sensitive gamma aminobutyric acid receptors, tolerance, and relevance to humans.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Ethanol; Female; Humans; Hypothalamo-Hypophyseal System; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Pituitary-Adrenal System; Receptors, GABA; Sensitivity and Specificity | 1998 |
Ventilatory effects of negative GABA(A) modulators in rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Diazepam; Female; GABA Modulators; Macaca mulatta; Male; Receptors, GABA-A; Respiration, Artificial | 1998 |
Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Male; Rats | 1997 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Depressants; Cerebellum; Cerebral Cortex; Chronic Disease; Ethanol; Flunitrazepam; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Precipitin Tests; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium; Zolpidem | 1999 |
Increased Ro15-4513-induced seizures following multiple ethanol withdrawals.
Topics: Animals; Azides; Benzodiazepines; Body Weight; Convulsants; Drug Synergism; Ethanol; GABA Agonists; Male; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1999 |
Preferential coassembly of alpha4 and delta subunits of the gamma-aminobutyric acidA receptor in rat thalamus.
Topics: Affinity Labels; Animals; Antibodies; Azides; Benzodiazepines; Binding, Competitive; Cells, Cultured; Humans; Rats; Receptors, GABA-A; Thalamus; Tritium | 1999 |
A significant part of native gamma-aminobutyric AcidA receptors containing alpha4 subunits do not contain gamma or delta subunits.
Topics: Antibodies, Monoclonal; Azides; Benzodiazepines; Binding Sites; Brain; Cell Line; Chromatography, Affinity; Humans; Muscimol; Precipitin Tests; Protein Binding; Receptors, GABA-A | 1999 |
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.
Topics: Animals; Azides; Behavior, Animal; Benzodiazepines; Brain; Female; Hypnotics and Sedatives; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscimol; Receptors, GABA-A; Sleep Wake Disorders; Steroids | 1999 |
Discriminative stimulus effects of flumazenil in untreated and in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Receptors, GABA-A | 1999 |
Furosemide action on cerebellar GABA(A) receptors in alcohol-sensitive ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Bicuculline; Bridged Bicyclo Compounds, Heterocyclic; Carbolines; Cerebellum; Drug Combinations; Female; Furosemide; GABA Agonists; GABA Antagonists; Ligands; Male; Pyridazines; Rats; Receptors, GABA-A; Sodium Chloride | 1999 |
Synthesis and evaluation of [123I]labelled analogues of the partial inverse agonist Ro 15-4513 for the study of diazepam-insensitive benzodiazepine receptors.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Brain; Diazepam; Female; Indicators and Reagents; Iodine Radioisotopes; Molecular Structure; Radioligand Assay; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, GABA-A; Structure-Activity Relationship; Tissue Distribution | 1999 |
Naloxone reverses disinhibitory/aggressive behavior in 5,7-DHT-lesioned rats; involvement of GABA(A) receptor blockade?
Topics: 5,7-Dihydroxytryptamine; Aggression; Amobarbital; Animals; Azides; Benzodiazepines; Drinking; GABA Modulators; Impulsive Behavior; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Serotonin; Serotonin Agents | 1999 |
Effects of the chlorotriazine herbicide, cyanazine, on GABA(A) receptors in cortical tissue from rat brain.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Chlorine; GABA Agonists; Herbicides; Male; Muscimol; Radioisotopes; Rats; Rats, Long-Evans; Receptors, GABA-A; Synaptosomes; Triazines | 1999 |
Cyclic AMP-mediated regulation of GABA(A) receptor subunit expression in mature rat cerebellar granule cells: evidence for transcriptional and translational control.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cellular Senescence; Cerebellum; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Intracellular Membranes; Neurons; Protein Isoforms; Rats; Rats, Wistar; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2000 |
Identification of benzodiazepine binding site residues in the gamma2 subunit of the gamma-aminobutyric acid(A) receptor.
Topics: Amino Acid Sequence; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Cloning, Molecular; Flumazenil; Flunitrazepam; Humans; Molecular Sequence Data; Point Mutation; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Homology, Amino Acid | 2000 |
Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
Topics: Allosteric Site; Animals; Anti-Anxiety Agents; Anticonvulsants; Azides; Benzodiazepines; Binding, Competitive; Brain; Cell Line; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Fluorobenzenes; GABA-A Receptor Antagonists; Hypnotics and Sedatives; Ligands; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Motor Activity; Patch-Clamp Techniques; Receptors, GABA-A; Reflex, Startle; Triazoles | 2000 |
Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines.
Topics: Alternative Splicing; Animals; Azides; Benzodiazepines; Brain; Carbolines; Diazepam; Drug Resistance; Female; Flumazenil; GABA Modulators; Genetic Variation; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Midazolam; Pyridines; Receptors, GABA-A; Sleep; Zolpidem | 2000 |
Antagonism of the discriminative stimulus effects of positive gamma-aminobutyric acid(A) modulators in rhesus monkeys discriminating midazolam.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Diazepam; Discrimination Learning; Drug Antagonism; Female; Flumazenil; GABA Modulators; Macaca mulatta; Male; Midazolam; Receptors, GABA-A | 2000 |
Blockade of latent inhibition following pharmacological increase or decrease of GABA(A) transmission.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Chlordiazepoxide; Convulsants; Dose-Response Relationship, Drug; GABA Modulators; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Pentylenetetrazole; Rats; Rats, Wistar; Reflex, Startle | 2000 |
Characterization of gamma-aminobutyrate type A receptors with atypical coupling between agonist and convulsant binding sites in discrete brain regions.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Cerebellum; Chickens; Convulsants; GABA Agonists; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Picrotoxin; Radioligand Assay; Rats; Rats, Wistar; Receptors, GABA-A; Sesterterpenes; Sulfur Radioisotopes; Thalamus; Tritium | 2001 |
Assembly of functional alpha6beta3gamma2delta GABA(A) receptors in vitro.
Topics: Affinity Labels; Anesthetics; Animals; Anticonvulsants; Azides; Benzodiazepines; Binding Sites; Cells, Cultured; Desoxycorticosterone; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Membrane Potentials; Muscimol; Protein Structure, Tertiary; Rats; Receptors, GABA-A; Transfection; Triazoles; Tritium | 2000 |
Diazepam during prior ethanol withdrawals does not alter seizure susceptibility during a subsequent withdrawal.
Topics: Affinity Labels; Alcohol Withdrawal Seizures; Animals; Anticonvulsants; Azides; Benzodiazepines; Brain; Central Nervous System Depressants; Diazepam; Electroencephalography; Ethanol; Male; Rats; Rats, Sprague-Dawley | 2001 |
Identification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Anti-Anxiety Agents; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; DNA, Complementary; Female; Flumazenil; Flunitrazepam; GABA-A Receptor Agonists; Humans; Imidazoles; Isoleucine; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Protein Binding; Protein Structure, Tertiary; Protein Subunits; Pyridazines; Pyridines; Receptors, GABA-A; Recombinant Fusion Proteins; Sequence Alignment; Structure-Activity Relationship; Threonine; Transfection; Xenopus laevis; Zolpidem | 2001 |
Mice performance on the staircase test following acute ethanol administration.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Diazepam; Dose-Response Relationship, Drug; Ethanol; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred ICR; Psychomotor Performance | 2001 |
GABA(A) receptor gene expression in rat cortex: differential effects of two chronic diazepam treatment regimes.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; Gene Expression; Infusion Pumps, Implantable; Injections, Subcutaneous; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Tritium | 2001 |
Altered gabaa receptor subunit and splice variant expression in rats treated with chronic intermittent ethanol.
Topics: Alcoholism; Alternative Splicing; Animals; Azides; Benzodiazepines; Cerebellum; Cerebral Cortex; Ethanol; Gene Expression; Hippocampus; Histocytochemistry; Kinetics; Male; Photoaffinity Labels; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2001 |
Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Carbolines; Conditioning, Psychological; Convulsants; Fear; Flumazenil; GABA Antagonists; GABA Modulators; Imidazoles; Ligands; Male; Memory; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylscopolamine; Piperazines; Quinolines; Receptors, GABA-A; Scopolamine; Silanes; Tritium | 2001 |
Modulation of ethanol-induced motor incoordination by mouse striatal A(1) adenosinergic receptor.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Affinity Labels; Animals; Antihypertensive Agents; Ataxia; Azides; Benzodiazepines; Central Nervous System Depressants; Corpus Striatum; Ethanol; Male; Mice; Mice, Inbred ICR; Microinjections; Motor Activity; Pertussis Toxin; Phenethylamines; Receptor, Adenosine A2A; Receptors, Purinergic P1; Vasodilator Agents; Virulence Factors, Bordetella; Xanthines | 2001 |
Benzodiazepines protect against ethanol-induced gastric mucosal damage in vitro.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Clonazepam; Ethanol; Flumazenil; GABA Modulators; Gastric Mucosa; In Vitro Techniques; Male; Rats; Rats, Wistar; Stomach Ulcer | 2001 |
The effects of flumazenil, Ro 154513 and beta-CCM on the behaviour of control and stressed mice in the staircase test.
Topics: Animals; Arousal; Azides; Benzodiazepines; Carbolines; Dose-Response Relationship, Drug; Escape Reaction; Exploratory Behavior; Fear; Flumazenil; Immobilization; Male; Mice; Mice, Inbred BALB C; Sleep Deprivation; Sleep, REM; Social Isolation; Stress, Psychological | 2001 |
Effects of naltrexone and Ro 15-4513 on a multiple schedule of ethanol and Tang self-administration.
Topics: Animals; Azides; Benzodiazepines; Beverages; Drinking; Ethanol; Female; Macaca fascicularis; Male; Naltrexone; Narcotic Antagonists; Self Administration | 2001 |
Role of the histidine residue at position 105 in the human alpha 5 containing GABA(A) receptor on the affinity and efficacy of benzodiazepine site ligands.
Topics: Anticonvulsants; Arginine; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Binding, Competitive; Cell Line; Cells, Cultured; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Histidine; Humans; Ligands; Mutation; Protein Subunits; Receptors, GABA-A | 2002 |
Daily treatment with diazepam differentially modifies sensitivity to the effects of gamma-aminobutyric acid(A) modulators on schedule-controlled responding in rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Conditioning, Operant; Diazepam; Dose-Response Relationship, Drug; Electroshock; Food; GABA Agonists; GABA Antagonists; GABA Modulators; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A; Reinforcement Schedule; Triazolam | 2002 |
Altered receptor subtypes in the forebrain of GABA(A) receptor delta subunit-deficient mice: recruitment of gamma 2 subunits.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Female; GABA Agonists; gamma-Aminobutyric Acid; Ion Channels; Male; Mice; Mice, Knockout; Muscimol; Mutation; Neural Inhibition; Neurons; Radioligand Assay; Receptors, GABA-A; Synaptic Transmission; Tritium | 2002 |
PET imaging of ischemic neuronal death in the hippocampus of living monkeys.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain Ischemia; Carbon Radioisotopes; Cell Death; Dementia; Disease Models, Animal; Hippocampus; Lysine; Macaca; Maleimides; Neurons; Receptors, GABA-A; Receptors, Muscarinic; Tomography, Emission-Computed | 2002 |
Organotypic rat cerebellar slice culture as a model to analyze the molecular pharmacology of GABAA receptors.
Topics: Affinity Labels; Animals; Animals, Newborn; Azides; Benzodiazepines; Binding Sites; Cell Survival; Cells, Cultured; Cerebellum; Culture Techniques; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2002 |
Imaging the GABA-benzodiazepine receptor subtype containing the alpha5-subunit in vivo with [11C]Ro15 4513 positron emission tomography.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Carbon Radioisotopes; Cerebellum; Cerebral Cortex; Flumazenil; Hippocampus; Humans; Kinetics; Male; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tissue Distribution; Tomography, Emission-Computed | 2002 |
The benzodiazepine partial inverse agonist Ro15-4513 alters anticonvulsant and lethal effects of carbamazepine in amygdala-kindled rats.
Topics: Affinity Labels; Amygdala; Animals; Anticonvulsants; Azides; Benzodiazepines; Carbamazepine; Drug Interactions; Epilepsy; GABA-A Receptor Agonists; Kindling, Neurologic; Male; Rats; Rats, Sprague-Dawley | 2002 |
Effects of GABA(A) compounds on mCPP drug discrimination in rats.
Topics: Alprazolam; Animals; Azides; Benzodiazepines; Bicuculline; Conditioning, Operant; Discrimination, Psychological; Flumazenil; GABA Agonists; GABA Antagonists; Male; Pentylenetetrazole; Piperazines; Rats; Rats, Long-Evans; Receptors, GABA-A | 2002 |
Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Cell Line; Chloride Channels; Convulsants; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Motor Activity; Pentylenetetrazole; Point Mutation; Rats; Transfection | 2002 |
Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cattle; Chromatography, High Pressure Liquid; Databases as Topic; Detergents; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Models, Chemical; Models, Molecular; Molecular Sequence Data; Mollusca; Peptides; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proton-Translocating ATPases; Receptors, GABA-A; Sequence Homology, Amino Acid; Tyrosine | 2002 |
Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors.
Topics: Affinity Labels; Alcoholism; Allosteric Regulation; Anesthetics; Animals; Anxiety; Azides; Benzodiazepines; Benzodiazepinones; Binding Sites; Diazepam; Electrophysiology; Ethanol; GABA Modulators; Hippocampus; Hypnosis; Immunoblotting; Kinetics; Male; Maze Learning; Neurons; Pregnanediones; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Sleep | 2003 |
Visualization of alpha5 subunit of GABAA/benzodiazepine receptor by 11C Ro15-4513 using positron emission tomography.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Brain Mapping; Carbon Radioisotopes; Macaca mulatta; Male; Protein Subunits; Receptors, GABA-A; Tomography, Emission-Computed | 2003 |
Neurosteroid effects on GABAergic synaptic plasticity in hippocampus.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Female; gamma-Aminobutyric Acid; Hippocampus; Neural Inhibition; Neuronal Plasticity; Oligonucleotides, Antisense; Organ Culture Techniques; Pregnanolone; Rats; Rats, Long-Evans; Receptors, GABA; Synaptic Transmission | 2003 |
Automated synthesis of the ultra high specific activity of [11C]Ro15-4513 and its application in an extremely low concentration region to an ARG study.
Topics: Affinity Labels; Animals; Autoradiography; Azides; Benzodiazepines; Male; Rats; Rats, Wistar; Tomography, Emission-Computed | 2003 |
Decomposition of an aqueous solution of [11C]Ro 15-4513: implication of hydrated electrons in the radiolysis of [11C]Ro 15-4513.
Topics: Azides; Benzodiazepines; Photolysis; Pulse Radiolysis; Solutions | 2003 |
Stressor-like effects of cocaine on heat shock protein and stress-activated protein kinase expression in the rat hippocampus: interaction with ethanol and anti-toxicity drugs.
Topics: Animals; Azides; Benzazepines; Benzodiazepines; Central Nervous System Depressants; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Drug Administration Schedule; Ethanol; Heat-Shock Proteins; Hippocampus; Infusions, Parenteral; Ketanserin; Male; Mitogen-Activated Protein Kinases; Motor Activity; Muscarinic Antagonists; Pirenzepine; Rats; Serotonin Antagonists; Swimming | 2003 |
Metabolite analysis of [11C]Ro15-4513 in mice, rats, monkeys and humans.
Topics: Animals; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Haplorhini; Humans; Metabolic Clearance Rate; Mice; Organ Specificity; Radioisotope Dilution Technique; Radiopharmaceuticals; Rats; Species Specificity; Tissue Distribution; Tomography, Emission-Computed | 2003 |
Similar effects of cocaine and immobilization stress on the levels of heat-shock proteins and stress-activated protein kinases in the rat hippocampus, and on swimming behaviors: the contribution of dopamine and benzodiazepine receptors.
Topics: Animals; Arousal; Azides; Benzazepines; Benzodiazepines; Cocaine; Dopamine Agonists; Escape Reaction; Heat-Shock Proteins; Hippocampus; Immobilization; Injections, Intraperitoneal; Male; Mitogen-Activated Protein Kinases; Motor Activity; Neurons; Rats; Rats, Wistar; Receptors, Dopamine D1; Stress, Psychological | 2003 |
Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit changes in a model of alcohol withdrawal and dependence.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Diazepam; Drug Interactions; Ethanol; GABA Agonists; Hippocampus; Isoxazoles; Neurons; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Substance Withdrawal Syndrome; Zolpidem | 2004 |
Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety.
Topics: Animals; Anxiety; Autoradiography; Azides; Benzodiazepines; Female; GABA Agonists; Male; Mice; Mice, Knockout; Muscimol; Receptors, GABA; Receptors, GABA-A; Sulfur Radioisotopes; Synapses; Transfection | 2004 |
Characterization of the interaction of indiplon, a novel pyrazolopyrimidine sedative-hypnotic, with the GABAA receptor.
Topics: Acetamides; Animals; Azides; Benzodiazepines; Binding Sites; Brain; Cell Membrane; Cerebellum; Cerebral Cortex; Chloride Channels; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Kinetics; Male; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiophenes; Triazolam; Tritium; Zolpidem | 2004 |
Conformational changes at benzodiazepine binding sites of GABA(A) receptors detected with a novel technique.
Topics: Allosteric Site; Animals; Azides; Benzodiazepines; Binding Sites; Female; Protein Conformation; Rats; Receptors, GABA-A; Xenopus | 2005 |
Changes in in vivo [(3)H]-Ro15-4513 binding induced by forced swimming in mice.
Topics: Analysis of Variance; Animals; Azides; Benzodiazepines; Binding Sites; Body Temperature; Brain; Cold Temperature; Dose-Response Relationship, Drug; Drug Interactions; Hypothermia; Male; Mice; Naloxone; Narcotic Antagonists; Radioactivity; Stress, Physiological; Swimming; Time Factors; Tissue Distribution; Tritium | 2005 |
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons.
Topics: Action Potentials; Animals; Animals, Newborn; Azides; Benzodiazepines; Bicuculline; Blotting, Western; Cells, Cultured; Chlorides; Dose-Response Relationship, Drug; Electric Stimulation; GABA Agonists; GABA Antagonists; Humans; Immunohistochemistry; Immunoprecipitation; In Vitro Techniques; Indoles; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred C57BL; Neural Inhibition; Neurons; Patch-Clamp Techniques; Prokaryotic Initiation Factors; Protein Subunits; Pyridines; Receptors, GABA-A; Synapses; Synaptophysin; Transfection; Ventral Thalamic Nuclei; Zinc Compounds; Zolpidem | 2005 |
Selective labelling of diazepam-insensitive GABAA receptors in vivo using [3H]Ro 15-4513.
Topics: Animals; Azides; Benzodiazepines; Benzodiazepinones; Binding, Competitive; Cerebellum; Flumazenil; Humans; Isotope Labeling; Ligands; Lorazepam; Male; Mice; Mice, Transgenic; Prosencephalon; Receptors, GABA-A; Receptors, GABA-B; Tritium | 2005 |
Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice.
Topics: Affinity Labels; Animals; Antibodies; Azides; Benzodiazepines; Blotting, Western; Cerebellum; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; GABA Agonists; Immunoprecipitation; Mice; Mice, Knockout; Muscimol; Receptors, GABA-A | 2006 |
An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons.
Topics: Affinity Labels; Allosteric Regulation; Animals; Azides; Benzodiazepines; Cells, Cultured; Chloride Channels; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Modulators; Hepatic Encephalopathy; Hippocampus; Male; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pregnanolone; Rats; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission | 2006 |
Involvement of diazepam-insensitive benzodiazepine receptors in the suppression of DOI-induced head-twitch responses in diabetic mice.
Topics: Amphetamines; Animals; Azides; Behavior, Animal; Benzodiazepines; Bicuculline; Diabetes Mellitus, Experimental; Diazepam; Flumazenil; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Mice, Inbred ICR; Receptors, GABA-A; Serotonin Receptor Agonists | 2006 |
Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to alpha4/6beta3delta GABAA receptors.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Cell Line; Ethanol; GABA-A Receptor Antagonists; Humans; Ligands; Molecular Structure; Protein Subunits; Rats; Receptors, GABA-A | 2006 |
Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513.
Topics: Animals; Azides; Benzodiazepines; Carbolines; Electrophysiology; Esters; Ethanol; Flumazenil; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Molecular Structure; Mutation; Oocytes; Patch-Clamp Techniques; Protein Subunits; Receptors, GABA-A; Xenopus laevis | 2006 |
Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys.
Topics: Animals; Azides; Benzodiazepines; Conditioning, Operant; Cues; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Female; Flumazenil; GABA Agonists; GABA Modulators; Hypnotics and Sedatives; Macaca mulatta; Male; Pentobarbital; Pregnanolone; Receptors, GABA-A | 2006 |
Alcohol-sensitive GABA receptors and alcohol antagonists.
Topics: Alcohols; Animals; Azides; Benzodiazepines; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Receptors, GABA | 2006 |
Effects of ethanol on tonic GABA currents in cerebellar granule cells and mammalian cells recombinantly expressing GABA(A) receptors.
Topics: Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Ethanol; Furosemide; gamma-Aminobutyric Acid; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Recombinant Proteins; Xenopus | 2006 |
Low concentrations of ethanol do not affect radioligand binding to the delta-subunit-containing GABAA receptors in the rat brain.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Central Nervous System Depressants; Dose-Response Relationship, Drug; Ethanol; Immunoprecipitation; Male; Muscimol; Radioligand Assay; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Tritium | 2007 |
AMPA and kainate receptors mediate mutually exclusive effects on GABA(A) receptor expression in cultured mouse cerebellar granule neurones.
Topics: Animals; Animals, Newborn; Azides; Benzodiazepines; Cells, Cultured; Cerebellum; Excitatory Amino Acids; GABA Agonists; Gene Expression Regulation; Kainic Acid; Mice; Mice, Neurologic Mutants; Models, Biological; Muscimol; Neurons; Potassium Chloride; Protein Subunits; Radioligand Assay; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Signal Transduction; Tritium | 2008 |
GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit.
Topics: Adult; Azides; Benzodiazepines; Binding, Competitive; Brain; Carbon Radioisotopes; Dominance, Cerebral; Female; Hippocampus; Humans; Learning; Male; Memory; Middle Aged; Positron-Emission Tomography; Prefrontal Cortex; Protein Subunits; Psychiatric Status Rating Scales; Psychotic Disorders; Receptors, GABA-A; Schizophrenia | 2008 |
Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells.
Topics: Anesthetics; Animals; Azides; Behavior, Animal; Benzodiazepines; Blotting, Western; Central Nervous System Depressants; Dentate Gyrus; Electrophysiology; Ethanol; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnanediones; Protein Subunits; Receptors, GABA-A; Synapses | 2008 |
Alpha2-containing GABA(A) receptors are involved in mediating stimulant effects of cocaine.
Topics: Animals; Autoradiography; Azides; Benzodiazepines; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; Hyperkinesis; Mice; Mice, Knockout; Midazolam; Motor Activity; Protein Subunits; Receptors, GABA-A | 2008 |
Zolpidem generalization and antagonism in male and female cynomolgus monkeys trained to discriminate 1.0 or 2.0 g/kg ethanol.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Antagonism; Ethanol; Female; GABA Agonists; Generalization, Stimulus; Macaca fascicularis; Male; Pyridines; Zolpidem | 2008 |
Antagonism of the ethanol-like discriminative stimulus effects of ethanol, pentobarbital, and midazolam in cynomolgus monkeys reveals involvement of specific GABA(A) receptor subtypes.
Topics: Animals; Azides; Benzodiazepines; Discrimination Learning; Dose-Response Relationship, Drug; Ethanol; Female; Flumazenil; Macaca fascicularis; Male; Midazolam; Pentobarbital; Protein Subunits; Receptors, GABA-A | 2009 |
Quantitative analyses of [¹¹C]Ro15-4513 binding to subunits of GABAA/benzodiazepine receptor in the living human brain.
Topics: Adult; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Humans; Kinetics; Male; Positron-Emission Tomography; Protein Binding; Protein Subunits; Receptors, GABA-A; Tissue Survival; Young Adult | 2009 |
Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation.
Topics: Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Ethanol; GABA Antagonists; GABA Modulators; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Photoperiod; Receptors, GABA-A; Serotonin; Suprachiasmatic Nucleus | 2009 |
Inverse benzodiazepine agonist beta-CCM does not reverse learning deficit induced by sleep deprivation.
Topics: Animals; Autoradiography; Avoidance Learning; Azides; Benzodiazepines; Carbolines; Drug Inverse Agonism; GABA-A Receptor Antagonists; Male; Radioligand Assay; Rats; Sleep Deprivation | 2010 |
Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors.
Topics: Adult; Animals; Azides; Benzodiazepines; Binding Sites; Case-Control Studies; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dopamine; Female; Humans; Learning; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Nucleus Accumbens; Point Mutation; Polymorphism, Single Nucleotide; Receptors, GABA-A; Reward; Young Adult | 2010 |
Human locus coeruleus neurons express the GABA(A) receptor gamma2 subunit gene and produce benzodiazepine binding.
Topics: Adult; Autoradiography; Azides; Benzodiazepines; Female; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Humans; Locus Coeruleus; Male; Melanins; Neurons; Pyridines; Radioligand Assay; Receptors, GABA-A; Tyrosine 3-Monooxygenase; Zolpidem | 2010 |
Remarkable selectivity of the in vivo binding of [3H]Ro15-4513 to α5 subtype of benzodiazepine receptor in the living mouse brain.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding, Competitive; Brain; Carbolines; Dose-Response Relationship, Drug; Flumazenil; Flunitrazepam; Male; Mice; Protein Subunits; Receptors, GABA-A; Tritium | 2010 |
Alcohol- and alcohol antagonist-sensitive human GABAA receptors: tracking δ subunit incorporation into functional receptors.
Topics: Allosteric Regulation; Animals; Azides; Benzodiazepines; Carbolines; Cations, Divalent; Cell Line; Diazepam; Ethanol; Humans; Mutation; Patch-Clamp Techniques; Protein Subunits; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection; Zinc | 2010 |
A [11C]Ro15 4513 PET study suggests that alcohol dependence in man is associated with reduced α5 benzodiazepine receptors in limbic regions.
Topics: Adult; Alcoholism; Azides; Benzodiazepines; Carbon Radioisotopes; Case-Control Studies; Ethanol; Humans; Limbic System; Male; Memory; Nucleus Accumbens; Positron-Emission Tomography; Receptors, GABA-A | 2012 |
The cerebellar GABAAR α6-R100Q polymorphism alters ligand binding in outbred Sprague-Dawley rats in a similar manner as in selectively bred AT and ANT rats.
Topics: Alcoholism; Animals; Azides; Benzodiazepines; Binding Sites; Cerebellum; Drug Tolerance; Ethanol; Genotype; Male; Polymorphism, Genetic; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2011 |
GABAA receptors in the posterior, but not anterior, ventral tegmental area mediate Ro15-4513-induced attenuation of binge-like ethanol consumption in C57BL/6J female mice.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Azides; Benzodiazepines; Disease Models, Animal; Drinking; Drug Administration Routes; Ethanol; Female; GABA Modulators; GABA-A Receptor Agonists; Mice; Mice, Inbred C57BL; Microinjections; Sucrose; Ventral Tegmental Area | 2011 |
Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation.
Topics: Animals; Autoradiography; Azides; Behavior, Animal; Benzodiazepines; Binding Sites; Brain; Carbolines; Convulsants; Female; HEK293 Cells; Humans; Hypnotics and Sedatives; Ligands; Male; Mice; Mice, Inbred C57BL; Protein Binding; Protein Subunits; Pyridines; Receptors, GABA-A; Zolpidem | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepam; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Flunitrazepam; GABA Modulators; Male; Pentobarbital; Rats; Rats, Wistar; Reaction Time; Seizures; Sleep; Statistics, Nonparametric; Tritium | 2012 |
Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats.
Topics: Alcohol Drinking; Analysis of Variance; Animals; Azides; Benzodiazepines; Central Nervous System Depressants; Cognition; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Male; Maze Learning; Memory; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors; Water | 2012 |
Modulation of diazepam-insensitive GABA(A) receptors by micromolar concentrations of thyroxine and related compounds in vitro.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Brain; Central Nervous System Depressants; Diazepam; Electrophysiological Phenomena; Ethanol; GABA Modulators; Isoxazoles; Male; Membranes; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, GABA-A; Thyroid Hormones; Thyroxine | 2013 |
Alcohol selectivity of β3-containing GABAA receptors: evidence for a unique extracellular alcohol/imidazobenzodiazepine Ro15-4513 binding site at the α+β- subunit interface in αβ3δ GABAA receptors.
Topics: Animals; Azides; Benzodiazepines; Binding Sites; Dose-Response Relationship, Drug; Ethanol; Extracellular Fluid; Female; Protein Structure, Secondary; Protein Subunits; Rats; Receptors, GABA-A; Xenopus laevis | 2014 |
Influence of agonist induced internalization on [3H]Ro15-4513 binding-an application to imaging fluctuations in endogenous GABA with positron emission tomography.
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Carbon Radioisotopes; Cell Membrane; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Nipecotic Acids; Positron-Emission Tomography; Radiopharmaceuticals; Rats, Sprague-Dawley; Receptors, GABA-A; Tiagabine; Tritium | 2015 |
Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice.
Topics: Allosteric Regulation; Animals; Azides; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Illicit Drugs; Male; Mice; Mice, Inbred C57BL; Microdialysis; Receptors, GABA-A; Reward; Self Stimulation | 2016 |
Using [(11)C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism.
Topics: Adult; Affinity Labels; Alcoholism; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Hippocampus; Humans; Male; Memory; Nucleus Accumbens; Opioid-Related Disorders; Positron-Emission Tomography; Receptors, GABA-A | 2016 |
Exogenous dopamine reduces GABA receptor availability in the human brain.
Topics: Adult; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Dopamine Agents; Gyrus Cinguli; Humans; Levodopa; Ligands; Male; Middle Aged; Positron-Emission Tomography; Receptors, GABA; Young Adult | 2016 |
Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum.
Topics: Allosteric Regulation; Animals; Apomorphine; Azides; Behavior, Animal; Benzodiazepines; Brain; Central Nervous System Stimulants; Cerebellum; Diazepam; Dopamine Agonists; Flavones; GABA Modulators; Humans; Locomotion; Methamphetamine; Mice; Neurons; Receptors, GABA-A; Synaptic Transmission | 2016 |
Quantification of [
Topics: Azides; Benzodiazepines; Binding, Competitive; Brain; Healthy Volunteers; Humans; Male; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Receptors, GABA-A; Sensitivity and Specificity | 2017 |
Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity.
Topics: Adult; Azides; Behavior, Addictive; Benzodiazepines; Brain; Carbon Radioisotopes; Gambling; Humans; Impulsive Behavior; Male; Positron-Emission Tomography; Receptors, GABA-A | 2017 |
Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Autoradiography; Azides; Benzodiazepines; Carbon Radioisotopes; Disease Models, Animal; Female; GABA Agents; GABA-A Receptor Agonists; Male; Muscimol; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, GABA-A; Valproic Acid | 2017 |
Test-retest reproducibility of quantitative binding measures of [
Topics: Adult; Azides; Benzodiazepines; Brain; Carbon Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, GABA-A; Reproducibility of Results | 2017 |
GABA
Topics: Adult; Animals; Autism Spectrum Disorder; Azides; Behavior; Benzodiazepines; Carbon Radioisotopes; Case-Control Studies; Disease Models, Animal; Female; Flumazenil; Gray Matter; Humans; Male; Mice; Motion Perception; Positron-Emission Tomography; Protein Subunits; Receptors, GABA-A; Task Performance and Analysis | 2018 |
Attenuation of dopamine-induced GABA release in problem gamblers.
Topics: Adult; Azides; Benzodiazepines; Dopamine; Dopamine Agents; Double-Blind Method; Frontal Lobe; Gambling; gamma-Aminobutyric Acid; Humans; Levodopa; Male; Positron-Emission Tomography; Self-Control; Synaptic Transmission | 2019 |
Decreased GABA-A Receptor Binding in Association With β-Lactam Antibiotic Use.
Topics: Adult; Anti-Bacterial Agents; Azides; Benzodiazepines; Binding Sites; Floxacillin; Humans; Male; Protein Binding; Receptors, GABA-A | 2019 |
Hops compounds modulatory effects and 6-prenylnaringenin dual mode of action on GABA
Topics: Animals; Azides; Benzodiazepines; Binding, Competitive; Cyclohexenes; Dose-Response Relationship, Drug; Flavonoids; Flumazenil; Flunitrazepam; GABA Modulators; Humulus; Male; Molecular Docking Simulation; Plant Extracts; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Terpenes | 2020 |
Reduced neurosteroid potentiation of GABA
Topics: Adolescent; Adult; Animals; Azides; Benzodiazepines; Cells, Cultured; Cerebral Cortex; Child; Child, Preschool; Drug Resistant Epilepsy; Electrophysiological Phenomena; Female; GABA-A Receptor Agonists; Hippocampus; Humans; Infant; Male; Neurons; Neurosteroids; Oocytes; Patch-Clamp Techniques; Pregnanolone; Rats; Receptors, GABA-A; Xenopus; Young Adult | 2020 |