azides has been researched along with dihydropyridines in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (15.34) | 18.7374 |
| 1990's | 114 (69.94) | 18.2507 |
| 2000's | 24 (14.72) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zernig, G | 1 |
| Miyamoto, K; Nakamura, S; Wakusawa, S | 1 |
| Agresti, M; Amato, JM; Fleming, GF; Safa, AR | 1 |
| Naito, M; Tsuruo, T | 2 |
| Inoko, K; Koyama, M; Miyamoto, K; Takagi, K; Wakusawa, S | 1 |
| Komano, T; Saeki, T; Shimabuku, AM; Ueda, K | 1 |
| Holohan, PD; Rebbeor, J; Sokol, PP; White, KE | 1 |
| Charuk, JH; Reithmeier, RA | 1 |
| Beck, WT; Danks, MK; Friche, E | 1 |
| Bruggemann, EP; Currier, SJ; Gottesman, MM; Pastan, I | 1 |
| Anstett, M; Atassi, G; Bizzari, JP; Genton, A; Léonce, S; Pérez, V; Pierré, A | 1 |
| Cardarelli, CO; Currier, SJ; Gottesman, MM; Kane, SE; Pastan, I; Willingham, MC | 1 |
| Azuma, Y; Komano, T; Saeki, T; Shibano, Y; Shimabuku, AM; Ueda, K | 1 |
| Kanaoka, Y; Nakayama, H; Taki, M | 1 |
| Glossmann, H; Haase, H; Holtzhauer, M; Striessnig, J; Vetter, R | 1 |
| Gollasch, M; Hescheler, J; Offermanns, S; Rosenthal, W; Schmidt, A; Schultz, G; Spicher, K | 1 |
| Catterall, WA; Murphy, BJ; Striessnig, J | 1 |
| Akiyama, S; Furukawa, T; Ichikawa, M; Kuwazuru, Y; Shudo, N; Sumizawa, T; Yoshimura, A | 1 |
| Gottesman, MM; Horio, M; Lovelace, E; Pastan, I | 1 |
| Suzuki, H; Tatsuta, T; Tomida, A | 1 |
| Akiyama, S; Furukawa, T; Ichikawa, M; Nakazima, Y; Sumizawa, T; Yoshimura, A | 1 |
| Fukazawa, N; Sato, W; Suzuki, T; Tsuruo, T; Yusa, K | 1 |
| Maeda, H; Miyamoto, Y | 1 |
| Bates, SE; Dichek, HL; Fojo, AT; Gazdar, A; Loriaux, DL; Mickley, LA; Shieh, CY | 1 |
| Safa, AR; Tamai, I | 1 |
| Georges, E; Ling, V; Zhang, JT | 1 |
| Chen, AY; Liu, LF; Potmesil, M; Wall, ME; Wani, MC; Yu, C | 1 |
| Hofmann, F; Meyer, HE; Nastainczyk, W; Regulla, S; Schneider, T | 1 |
| Friedrich, K; Glossmann, H; Grabner, M; Knaus, HG; Koch, WJ; Scheffauer, F; Schwartz, A; Staudinger, R; Striessnig, J | 1 |
| Inada, H; Kikuchi, J; Kiue, A; Kohno, K; Kuwano, M; Okumura, M; Sano, T; Sato, S; Suzuki, K | 1 |
| Bruggemann, EP; Currier, SJ; Germann, UA; Gottesman, MM; Pastan, I; Tanaka, S; Ueda, K | 1 |
| Akiyama, S; Furukawa, T; Ichikawa, M; Sumizawa, T; Yoshimura, A | 1 |
| Akiyama, S; Douzono, H; Ikeda, S; Nagata, Y; Sugita, M; Sumizawa, T; Yoshimura, A | 1 |
| Gindin, E; Greenberger, LM; Horwitz, SB; Yang, CP | 1 |
| Bindslev, N; Demant, EJ; Friche, E; Jensen, PB; Sehested, M; Skovsgaard, T | 1 |
| Demant, EJ; Friche, E; Jensen, PB; Nissen, NN; Sehested, M | 1 |
| Inada, H; Kikuchi, J; Kiue, A; Kohno, K; Naito, A; Okumura, M; Sano, T; Sato, S; Suzuki, K; Takano, H | 1 |
| Furukawa, T; Hanada, S; Ishibashi, K; Kuwazuru, Y; Maruyama, M; Saito, T; Sumizawa, T; Uozumi, K; Utsunomiya, A; Yoshimura, A | 1 |
| Naito, M; Sato, W; Tsuruo, T; Yusa, K | 1 |
| Lemaire, S; Murphy, BJ; Rogers, CA; Sunahara, RK; Tuana, BS | 1 |
| Murphy, BJ; Sunahara, RK; Tuana, BS | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Rombusch, M | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Schober, M; Striessnig, J | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Kämpf, K | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Ferry, DR; Glossmann, H; Goll, A | 1 |
| Hofmann, F; Nastainczyk, W; Sieber, M; Wernet, W; Zubor, V | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Moosburger, K; Schirmer, M; Striessnig, J | 1 |
| Johnson, DF; Kuo, TH; Tsang, W; Wiener, J | 1 |
| Glossmann, H; Hymel, L; Schindler, H; Striessnig, J | 1 |
| Krizanová, O; Orlický, J; Zachar, J | 1 |
| Bruggemann, EP; Germann, UA; Gottesman, MM; Pastan, I | 1 |
| Akiyama, S; Ichikawa, M; Ikeda, S; Kuwazuru, Y; Sumizawa, T; Uda, T; Yoshimura, A | 1 |
| Flockerzi, V | 1 |
| Glossmann, H; Grassegger, A; Höltje, HD; Hymel, L; Knaus, HG; Marrer, S; Müller, J; Schindler, HG; Striessnig, J | 1 |
| Hudecová, S; Krizanová, O; Orlický, J; Zachar, J | 1 |
| Arceci, RJ; DePinho, SG; Greenberger, LM; Horwitz, SB; Yang, CP | 1 |
| Akiyama, S; Cornwell, MM; Kikuchi, J; Kiue, A; Kohno, K; Kuwano, M; Nogae, I; Pastan, I; Suzuki, K; Yoshida, Y | 1 |
| Akiyama, S; Kamiwatari, M; Kikuchi, H; Nagata, Y; Sakoda, R; Seto, K; Shudo, N; Sumizawa, T; Yoshimura, A | 1 |
| Akiyama, S; Hanada, S; Hashimoto, S; Kamiwatari, M; Kikuchi, H; Nagata, Y; Sakota, R; Seto, K; Utsunomiya, A; Yoshimura, A | 1 |
| Asoh, K; Kohno, K; Kuwano, M; Nogae, I; Saburi, Y; Sato, S | 1 |
| Safa, AR; Spearman, T; Van Dyke, K; Ye, ZG | 1 |
| Glossmann, H; Knaus, HG; Striessnig, J | 1 |
| Horwitz, SB; Mellado, W; Yang, CP | 1 |
| Campbell, KP; Imagawa, T; Leung, AT; Sharp, AH | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Rombush, M | 1 |
| Boiocchi, M; Cappelletto, B; Corona, G; Gigante, M; Raschack, M; Simone, F; Toffoli, G | 1 |
| Drímal, J | 1 |
| Gizinski, MJ; Schumaker, KS | 1 |
| Kawada, M; Umezawa, K | 1 |
| Boer, R; Borchers, C; Conrad, J; Gekeler, V; Haas, S; Ise, W; Klemm, K; Przybylski, M; Schödl, A; Ulrich, WR | 1 |
| Bennis, S; Ichas, F; Robert, J | 1 |
| Charuk, JH; Reithmeier, RA; Wong, PY | 1 |
| Hu, YP; Robert, J | 1 |
| Eliason, JF; Ishikawa, T; Ramuz, H; Tsuruo, T; Yamamoto, T; Yoshikubo, T | 1 |
| Bates, SE; Dickstein, B; Fojo, AT; Lee, JS; Spolyar, M | 1 |
| Ashbourne, KJ; DiDiodato, G; Sharom, FJ; Yu, X | 1 |
| Senior, AE; Urbatsch, IL | 1 |
| Boer, R; Gekeler, V; Glossmann, H; Gotwald, M; Hofer, S; Hofmann, J; Ise, W; Mitterdorfer, J; Noller, A; Utz, I | 1 |
| Koseki, Y; Lothstein, L; Sweatman, TW | 1 |
| Georges, E; Ling, V; Liu, Z; Zordan-Nudo, T | 1 |
| Boyle, B; Clarke, R; Jacobson, M; Leonessa, F; Lippman, J; McGarvey, M | 1 |
| Charuk, JH; Clarke, DM; Loo, TW; Reithmeier, RA | 1 |
| Clarke, DM; Loo, TW | 4 |
| Belani, CP; Gutheil, JC; Hart, SR; Hussain, A; Melera, PW | 1 |
| Ling, V; Poruchynsky, MS | 1 |
| Kang, Y; Perry, RR | 1 |
| Akiyama, S; Fujii, R; Furukawa, T; Matsumoto, T; Nagata, Y; Sakai, S; Sueda, N; Sugita, M; Sumizawa, T; Takahashi, T | 1 |
| Gajdzik, L; Graf, J; Stapf, V; Thalhammer, T | 1 |
| Ahmad, S; Glazer, RI; Safa, AR | 1 |
| Boiocchi, M; Gigante, M; Simone, F; Toffoli, G | 1 |
| Demant, EJ; Friche, E; Nissen, NI; Sehested, M | 1 |
| Chen, HX; Gesmonde, JF; Hait, WN; Murren, JR; Reiss, M; Yang, JM | 1 |
| Hasegawa, T; Inoko, K; Kajita, S; Koyama, M; Miyamoto, K; Takagi, K; Wakusawa, S | 1 |
| Abraham, I; Sampson, KE; Wolf, CL | 1 |
| Akiyama, S; Furukawa, T; Ichikawa-Haraguchi, M; Nishiyama, K; Ohi, Y; Shirahama, T; Sumizawa, T; Yoshimura, A | 1 |
| Chen, G; Krishan, A; Ramachandran, C | 1 |
| Hori, R; Komano, T; Saeki, T; Tanigawara, Y; Ueda, K | 1 |
| Harwood, FC; Horton, JK; Houghton, PJ; Kuttesch, JF; Thimmaiah, KN | 1 |
| Itagaki, K; Kalasz, H; Naito, K; Nakayama, H; Schwartz, A; Vaghy, PL; Watanabe, T; Yabana, H | 1 |
| Aoudjit, F; Dupuis, G; Payet, MD; Ricard, I | 1 |
| Hoffman, MM; Roepe, PD; Stutts, MJ; Wei, LY | 1 |
| Balasubramanian, M; Buckingham, LE; Coon, JS; Emanuele, RM; Komarov, P; Safa, AR; Shah, H | 1 |
| Christensen, JG; LeBlanc, GA | 1 |
| Bergman, PJ; Gravitt, KR; Gupta, KP; O'Brian, CA; Ward, NE | 1 |
| Abou-Donia, MB; Corcoran, JJ; Fine, RL; Lanning, CL; Rao, US; Sachs, CW | 1 |
| Kobayashi, D; Miyamoto, K; Ohmae, S; Sanae, F; Takag, K | 1 |
| Bamberger, U; Georges, E; Heckel, A; Lheureux, F; Liu, Z; Pouliot, JF | 1 |
| Hidaka, H; Minamino, T; Miyamoto, K; Nakamura, S; Nomura, M; Wakusawa, S | 1 |
| Boer, R; Gekeler, V; Grunicke, H; Hofmann, J; Ise, W; Klemm, K; Sanders, KH; Schächtele, C; Schubert, C; Uberall, F; Utz, I | 1 |
| Bell, SE; Bentley, J; Kellett, GL; Quinn, DM; Warr, JR | 1 |
| Kameyama, A; Kameyama, M; Sekiguchi, K; Shearman, MS | 1 |
| Drímal, J; Koprda, V | 1 |
| Chu, JW; DiDiodato, G; Sharom, FJ; Yu, X | 1 |
| Cullen, JM; Dunn, SE | 1 |
| Chapey, C; Hu, YP; Robert, J | 1 |
| Gilsdorf, JS; Holohan, PD; Rebbeor, JF | 1 |
| Chen, G; Dumontet, C; Durán, GE; Jaffrézou, JP; Lacayo, NJ; Sikic, BI; Steger, KA | 1 |
| Abu Khoudoud, OR; Bikhazi, AB; Bitar, KM; el-Kasti, MM; Ibrahim, MZ; Kreydiyyeh, SI; Saleh, RS | 1 |
| Bertola, A; Boiocchi, M; Corona, G; Sorio, R; Toffoli, G | 1 |
| Akhmed, N; Bates, SE; Dickstein, B; Elgemeie, GH; Lan, LB; Lee, JS; Paull, K; Rao, US; Scala, S; Stein, WD | 1 |
| Akiyama, S; Furukawa, T; Ikeda, S; Nagata, Y; Nakamura, Y; Sumizawa, T; Tani, A | 1 |
| Hait, WN; LaVoie, EJ; Makhey, DB; Sullivan, GF; Yang, JM | 1 |
| Hayashi, M; Komiyama, K; Omura, S; Rho, MC; Shiomi, K; Toyoshima, M; Uchida, R | 1 |
| Greenberger, LM | 1 |
| Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M | 1 |
| Charuk, MH; Grey, AA; Reithmeier, RA | 1 |
| Inami, M; Kawamura, I; Manda, T; Matsumoto, S; Naoe, Y; Nishigaki, F; Shimomura, K; Takagaki, S; Tsujimoto, S | 1 |
| Böhme, M; Keppler, D; Koester, M; Wallstab, A | 1 |
| Bradshaw, D; Drew, L; Harris, W; Hill, CH; Khan, A; Merritt, JE; Mulqueen, M; Rumsby, M; Sullivan, JA; Warr, R; Wilson, K | 1 |
| Ling, V; Ruysschaert, JM; Shapiro, AB; Sonveaux, N; Vigano, C | 1 |
| Chu, JW; Hose, CD; Liu, R; Lu, P; Monks, A; Müller, M; Sarkadi, B; Seprôdi, J; Sharom, FJ; Szabó, K; Váradi, A; Yu, X | 1 |
| Andreae, S; Demmer, A; Thole, H; Tümmler, B | 1 |
| Altenberg, GA; Castro, AF; Horton, JK; Vanoye, CG | 1 |
| Fujita, R; Ishikawa, M; Sasaki, K; Takayanagi, M; Takayanagi, Y | 2 |
| Chen, KG; Cohen, D; Durán, GE; Lacayo, NJ; Sikic, BI | 1 |
| Boer, R; Callaghan, R; Ferry, D; Ulrich, WR | 1 |
| Komada, F; Nishiguchi, K; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y | 2 |
| Fujita, R; Ishikawa, M; Miyake, N; Sasaki, K; Takayanagi, M; Takayanagi, Y | 1 |
| Aikou, T; Akiyama, SI; Chen, ZS; Furukawa, T; Hirota, K; Ikeda, R; Komatsu, M; Okumura, H; Sakou, M; Sumizawa, T; Suzuki, H | 1 |
| Fukami, A; Hayashi, M; Komiyama, K; Obata, R; Omura, S; Rho, MC; Sunazuka, T; Tomoda, H | 1 |
| Bootle, D; Charlton, P; Dangerfield, W; Liddle, C; Mistry, P; Okiji, S; Plumb, JA; Stewart, AJ; Templeton, D | 1 |
| Fujita, R; Furusawa, S; Ishikawa, M; Kataoka, Y; Miura, M; Sasaki, K; Takayanagi, M; Takayanagi, Y; Takeshita, M | 1 |
| Lawrence, DS; Myers, CB; Smith, CD; Smith, SN; Zilfou, JT | 1 |
| Chou, KM; Hacker, MP; Paul Krapcho, A | 1 |
| Blott, E; Callaghan, R; Gabriel, M; Higgins, CF; Linton, KJ; Martin, C; Soceneantu, L; Storm, J; Taylor, AM; Woodhouse, J | 1 |
| Boer, R; Borchers, C; Denzinger, T; Figala, V; Gekeler, V; Haas, S; Ise, W; Klemm, K; Przybylski, M; Ulrich, WR | 1 |
| Chi, DW; Kim, SW; Kwon, HY; Lee, YH; Park, JD; Pyo, S; Rhee, DK; Shim, JH | 1 |
| Chu, JW; Qu, Q; Sharom, FJ | 1 |
| Morris, ME; Zhang, S | 1 |
| Castanys, S; Conseil, G; Dayan, G; Di Pietro, A; Gamarro, F; Marsaud, V; Munoz-Martinez, F; Perez-Victoria, JM; Perez-Victorias, FJ; Renoir, JM | 1 |
| Escalon, EA; Fonseca, HB; Melnick, SJ; Rabi, T; Ramachandran, C | 1 |
| Ambudkar, SV; Nandigama, K; Peng, XH; Sauna, ZE; Tekle, S | 1 |
| Castanys, S; Cortés-Selva, F; Gamarro, F; Jiménez, IA; Lu, P; Muñoz-Martínez, F; Pérez-Victoria, JM; Ravelo, AG; Sharom, FJ | 1 |
| Hu, X; Lu, Q; Qiangrong, P; Wang, T | 1 |
| Ambudkar, SV; Bates, SE; Robey, RW; Shukla, S | 1 |
| Ambudkar, SV; Chearwae, W; Limtrakul, P; Shukla, S | 1 |
2 review(s) available for azides and dihydropyridines
| Article | Year |
|---|---|
The molecular pharmacology and structural features of calcium channels.
Topics: Animals; Autoradiography; Azides; Brain; Calcium; Calcium Channels; Cations, Divalent; Dihydropyridines; Guinea Pigs; Ion Channels; Nicotinic Acids; Nimodipine; Pyridines; Radioligand Assay; Receptors, Nicotinic; Solubility; Subcellular Fractions | 1985 |
Structure of calcium channels.
Topics: Affinity Labels; Azides; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Molecular Structure; Muscles; Piperidines; Receptors, Nicotinic; Structure-Activity Relationship; Thiazepines; Thiazines | 1989 |
161 other study(ies) available for azides and dihydropyridines
| Article | Year |
|---|---|
Photoaffinity labeling of the partially purified mitochondrial phenylalkylamine calcium antagonist receptor.
Topics: Affinity Labels; Azides; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Mitochondria; Verapamil | 1992 |
Drug resistance dependent on different molecular size P-glycoproteins in Yoshida rat ascites hepatoma cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport, Active; Cell Line; Cell Membrane; Dihydropyridines; Drug Resistance; Female; Liver Neoplasms, Experimental; Membrane Glycoproteins; Molecular Structure; Neoplasm Proteins; p-Dimethylaminoazobenzene; Rats; Vinblastine | 1992 |
Megestrol acetate reverses multidrug resistance and interacts with P-glycoprotein.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cells, Cultured; Chemical Phenomena; Chemistry, Physical; Cricetinae; Cricetulus; Dihydropyridines; Drug Interactions; Drug Resistance; Epithelial Cells; Epithelium; Humans; Iodine Radioisotopes; Lung; Megestrol; Megestrol Acetate; Membrane Glycoproteins; Neuroblastoma; Progesterone; Tritium; Tumor Cells, Cultured; Vincristine; Vindesine | 1992 |
Functionally active homodimer of P-glycoprotein in multidrug-resistant tumor cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macromolecular Substances; Membrane Glycoproteins; Mitolactol; Mitomycins; Precipitin Tests; Succinimides; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Reversal of vinblastine resistance by a new staurosporine derivative, NA-382, in P388/ADR cells.
Topics: Affinity Labels; Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Division; Cell Line; Cell Membrane; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Leukemia P388; Membrane Glycoproteins; Protein Kinase C; Staurosporine; Vinblastine | 1992 |
Specific drug binding by purified lipid-reconstituted P-glycoprotein: dependence on the lipid composition.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; beta-Galactosidase; Biological Transport; Cholesterol; Dihydropyridines; Ergosterol; Humans; Lipid Metabolism; Lipids; Liposomes; Membrane Glycoproteins; Mice; Recombinant Fusion Proteins; Stigmasterol; Transfection | 1992 |
Photoaffinity labeling of the organic cation/H+ exchanger in renal brush border membrane vesicles.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cations; Dihydropyridines; Dithiothreitol; Dogs; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Hydrogen; Kidney Cortex; Membrane Glycoproteins; Microvilli; Photochemistry; Prazosin; Substrate Specificity | 1992 |
Interaction of P-glycoprotein with a hydrophobic component of rat urine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; CHO Cells; Cricetinae; Dihydropyridines; Drug Resistance; Female; Kinetics; Male; Membrane Glycoproteins; Rats; Tissue Extracts; Urine; Verapamil; Vinblastine | 1992 |
Characterization of tumor cell resistance to 4'-deoxy-4'-iododoxorubicin developed in Ehrlich ascites cells in vivo.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cell Line; Daunorubicin; Dihydropyridines; DNA Topoisomerases, Type II; DNA-Binding Proteins; Doxorubicin; Drug Resistance; Macromolecular Substances; Membrane Glycoproteins; Mice; Neoplasm Proteins; Teniposide; Tumor Cells, Cultured | 1992 |
Characterization of the azidopine and vinblastine binding site of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Cell Membrane; Colchicine; Cyanogen Bromide; Dihydropyridines; Drug Resistance; Humans; KB Cells; Kinetics; Membrane Glycoproteins; Molecular Weight; Peptide Fragments; Transfection; Trypsin; Verapamil; Vinblastine; Vincristine | 1992 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Squamous Cell; Cell Cycle; Cell Membrane; Cells, Cultured; Colonic Neoplasms; Cricetinae; Cricetulus; Dihydropyridines; Doxorubicin; Drug Resistance; Flow Cytometry; Fluorescence; Humans; Kinetics; Leukemia P388; Leukemia, Myeloid, Acute; Lung; Membrane Glycoproteins; Mice; Piperidines; Sensitivity and Specificity; Triazines; Tritium; Tumor Cells, Cultured; Verapamil | 1992 |
Identification of residues in the first cytoplasmic loop of P-glycoprotein involved in the function of chimeric human MDR1-MDR2 transporters.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Base Sequence; Dihydropyridines; Drug Resistance; Humans; Membrane Glycoproteins; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Structure, Secondary; Recombinant Fusion Proteins; Restriction Mapping; Sequence Homology, Amino Acid; Transfection | 1992 |
Expression of human P-glycoprotein in yeast cells--effects of membrane component sterols on the activity of P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Base Sequence; Cell Membrane; Dihydropyridines; Doxorubicin; Ergocalciferols; Ergosterol; Gene Expression; Genetic Vectors; Humans; Membrane Glycoproteins; Molecular Sequence Data; Saccharomyces cerevisiae; Sterols; Tritium | 1991 |
Diazipine, a novel photoaffinity probe for dihydropyridine receptors of calcium channels.
Topics: Affinity Labels; Animals; Azides; Azirines; Calcium Channel Blockers; Calcium Channels; Chromatography, Affinity; Dihydropyridines; Kinetics; Molecular Weight; Muscles; Rabbits; Receptors, Nicotinic | 1991 |
A rapid procedure for the purification of cardiac 1,4-dihydropyridine receptors from porcine heart.
Topics: Affinity Labels; Animals; Azides; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Isradipine; Membranes; Myocardium; Phosphorylation; Photochemistry; Protein Kinases; Receptors, Nicotinic; Sarcolemma; Swine | 1991 |
Inhibition of voltage-dependent Ca2+ currents and activation of pertussis toxin-sensitive G-proteins via muscarinic receptors in GH3 cells.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Carbachol; Cell Line; Dihydropyridines; Electric Conductivity; GTP-Binding Proteins; Guanosine Triphosphate; Molecular Weight; Pertussis Toxin; Photochemistry; Pituitary Gland; Prolactin; Rats; Receptors, Muscarinic; Virulence Factors, Bordetella | 1991 |
Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.
Topics: Amino Acid Sequence; Animals; Antibodies; Azides; Binding Sites; Binding Sites, Antibody; Calcium Channel Blockers; Calcium Channels; Chromatography, Affinity; Dihydropyridines; Isradipine; Macromolecular Substances; Molecular Sequence Data; Muscles; Peptide Fragments; Peptides; Receptors, Nicotinic; Tritium; Trypsin | 1991 |
Interaction of organic chemicals with P-glycoprotein in the adrenal gland, kidney, and a multidrug-resistant KB cell.
Topics: Adrenal Glands; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Blotting, Western; Carrier Proteins; Cell Line; Coloring Agents; Dihydropyridines; Dinitrophenols; Drug Resistance; Humans; Kidney; Membrane Glycoproteins | 1991 |
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Biological Transport, Active; Carcinoma, Squamous Cell; Cell Membrane; Dihydropyridines; Drug Resistance; Humans; Kinetics; Leucine; Membrane Glycoproteins; Phenothiazines; Quinidine; Trifluoperazine; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Novel mechanism of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine in potentiation of antitumor drug action on multidrug-resistant and sensitive Chinese hamster cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane; Cricetinae; Cricetulus; Daunorubicin; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Synergism; Ethylenediamines; Membrane Glycoproteins; Terpenes; Verapamil; Vinblastine | 1991 |
Glycosylation of P-glycoprotein in a multidrug-resistant KB cell line, and in the human tissues.
Topics: Adrenal Glands; Affinity Labels; Amidohydrolases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance; Glucosamine; Glycosylation; Hexosaminidases; Humans; Immunoblotting; Kidney; Liver; Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; Membrane Glycoproteins; Molecular Weight; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Photochemistry; Protein Processing, Post-Translational; Tissue Distribution; Tumor Cells, Cultured; Tunicamycin | 1991 |
Circumvention of multidrug resistance by a newly synthesized quinoline derivative, MS-073.
Topics: Affinity Labels; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Administration Schedule; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Female; Leukemia P388; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Piperazines; Quinolines; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
Enhancement by verapamil of neocarzinostatin action on multidrug-resistant Chinese hamster ovary cells: possible release of nonprotein chromophore in cells.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Division; Cell Line; Cell Membrane; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Dihydropyridines; Drug Resistance; Drug Synergism; Female; Kinetics; Membrane Glycoproteins; Ovary; Verapamil; Zinostatin | 1991 |
Mitotane enhances cytotoxicity of chemotherapy in cell lines expressing a multidrug resistance gene (mdr-1/P-glycoprotein) which is also expressed by adrenocortical carcinomas.
Topics: Adrenal Cortex Neoplasms; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Dactinomycin; Dihydropyridines; Drug Resistance; Gene Expression; Humans; Membrane Glycoproteins; Mitotane; Nucleic Acid Hybridization; RNA, Messenger; Tumor Cells, Cultured; Vinblastine | 1991 |
Azidopine noncompetitively interacts with vinblastine and cyclosporin A binding to P-glycoprotein in multidrug resistant cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Biological Transport; Cell Line; Cell Membrane; Cricetinae; Cyclosporins; Dihydropyridines; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Kinetics; Membrane Glycoproteins; Vinblastine | 1991 |
Modulation of ATP and drug binding by monoclonal antibodies against P-glycoprotein.
Topics: Adenosine Triphosphate; Affinity Labels; Amino Acid Sequence; Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Membrane; CHO Cells; Cricetinae; Dihydropyridines; Drug Resistance; Membrane Glycoproteins; Models, Structural; Molecular Sequence Data; Protein Conformation | 1991 |
Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Camptothecin; Dihydropyridines; Drug Resistance; Humans; KB Cells; Membrane Glycoproteins; Topotecan | 1991 |
Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel alpha 1 subunit.
Topics: Amino Acid Sequence; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Kinetics; Models, Biological; Molecular Sequence Data; Muscles; Myocardium; Nitrendipine; Peptide Fragments; Rabbits | 1991 |
Calcium channels from Cyprinus carpio skeletal muscle.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Biological Evolution; Calcium Channels; Carps; Dihydropyridines; Macromolecular Substances; Molecular Sequence Data; Muscles; Rabbits; Sequence Homology, Nucleic Acid | 1991 |
Activities of newly synthesized dihydropyridines in overcoming of vincristine resistance, calcium antagonism, and inhibition of photoaffinity labeling of P-glycoprotein in rodents.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Drug Resistance; Leukemia P388; Male; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Structure-Activity Relationship; Vincristine | 1990 |
Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.
Topics: Affinity Labels; Animals; Antibodies; Antibodies, Monoclonal; Antigen-Antibody Reactions; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Base Sequence; Blotting, Western; Cloning, Molecular; Dihydropyridines; Drug Resistance; Escherichia coli; Genetic Vectors; Humans; Membrane Glycoproteins; Methionine; Molecular Sequence Data; Molecular Weight; Neoplasm Proteins; Peptide Fragments; Plasmids; Rabbits; Recombinant Proteins | 1990 |
Modulators of the multidrug-transporter, P-glycoprotein, exist in the human plasma.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Blood Proteins; Cell Survival; Chromatography, High Pressure Liquid; Daunorubicin; Dihydropyridines; Drug Resistance; Humans; KB Cells; Kinetics; Membrane Glycoproteins; Molecular Weight; Neoplasm Proteins; Vinblastine | 1990 |
Aspergillus species strain M39 produces two naphtho-gamma-pyrones that reverse drug resistance in human KB cells.
Topics: Aspergillus; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Chemical Phenomena; Chemistry; Dihydropyridines; Doxorubicin; Drug Resistance; Humans; Membrane Glycoproteins; Naphthols; Pyrans; Pyrones; Verapamil; Vinblastine | 1990 |
Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Binding, Competitive; Calcium Channels; Cell Line; Cell Membrane; Chymotrypsin; Dihydropyridines; Drug Resistance; Macrophages; Membrane Glycoproteins; Mice; Peptide Mapping; Prazosin; Receptors, Adrenergic, alpha; Sequence Homology, Nucleic Acid; Verapamil | 1990 |
Transport of the multidrug resistance modulators verapamil and azidopine in wild type and daunorubicin resistant Ehrlich ascites tumour cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cells, Cultured; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Humans; In Vitro Techniques; Membrane Glycoproteins; Verapamil; Vincristine | 1990 |
The solvents cremophor EL and Tween 80 modulate daunorubicin resistance in the multidrug resistant Ehrlich ascites tumor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Ehrlich Tumor; Cyclosporins; Daunorubicin; Dihydropyridines; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Glycerol; Humans; Intracellular Membranes; Membrane Glycoproteins; Polysorbates; Tritium; Tumor Cells, Cultured; Verapamil | 1990 |
Reversal by two dihydropyridine compounds of resistance to multiple anticancer agents in mouse P388 leukemia in vivo and in vitro.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dactinomycin; Dihydropyridines; Dioxins; Drug Resistance; Drug Synergism; Leukemia P388; Male; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Tritium; Vinblastine; Vincristine; Vindesine | 1990 |
Expression of P-glycoprotein in adult T-cell leukemia cells.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blast Crisis; Cell Line; Dihydropyridines; Gene Expression Regulation, Leukemic; Humans; Immunoblotting; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Lymph Nodes; Membrane Glycoproteins; Nimodipine; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Progesterone; RNA, Messenger; Tritium; Vinblastine | 1990 |
Staurosporine, a potent inhibitor of C-kinase, enhances drug accumulation in multidrug-resistant cells.
Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Drug Resistance; Humans; Membrane Glycoproteins; Phosphorylation; Protein Kinases; Staurosporine; Tumor Cells, Cultured; Vincristine | 1990 |
Identification, characterization, and photoaffinity labeling of the dihydropyridine receptor associated with the L-type calcium channel from bovine adrenal medulla.
Topics: Adrenal Medulla; Affinity Labels; Allosteric Regulation; Animals; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Cattle; Dihydropyridines; Hot Temperature; Isradipine; Oxadiazoles; Photochemistry; Radioligand Assay; Receptors, Nicotinic; Stereoisomerism; Sulfhydryl Reagents | 1990 |
A sensitive and rapid method for identification and characterization of low abundance receptors.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Methods; Muscles; Peptide Hydrolases; Peptide Mapping; Rabbits; Receptors, Nicotinic; Scintillation Counting | 1990 |
Calcium channels: basic properties as revealed by radioligand binding studies.
Topics: Affinity Labels; Animals; Azides; Binding Sites; Binding, Competitive; Brain; Calcium; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Iodobenzenes; Ion Channels; Molecular Weight; Muscles; Neurilemma; Photochemistry; Pyridines; Sarcolemma; Verapamil | 1985 |
Subunit composition of skeletal muscle transverse tubule calcium channels evaluated with the 1,4-dihydropyridine photoaffinity probe, [3H]azidopine.
Topics: Affinity Labels; Animals; Azides; Cell Fractionation; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Ion Channels; Membrane Proteins; Molecular Conformation; Molecular Weight; Muscles; Pyridines; Tritium | 1985 |
Stereoselective photoaffinity labelling of the purified 1,4-dihydropyridine receptor of the voltage-dependent calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Dihydropyridines; Guinea Pigs; Ion Channels; Muscles; Photochemistry; Pyridines; Radioligand Assay; Receptors, Nicotinic; Solubility; Stereoisomerism | 1986 |
Photoaffinity labelling of the cardiac calcium channel. (-)-[3H]azidopine labels a 165 kDa polypeptide, and evidence against a [3H]-1,4-dihydropyridine-isothiocyanate being a calcium-channel-specific affinity ligand.
Topics: Affinity Labels; Animals; Azides; Calcium; Cell Membrane; Dihydropyridines; Electrophoresis, Polyacrylamide Gel; Guinea Pigs; Heart; Hexobendine; Ion Channels; Isothiocyanates; Myocardium; Nicardipine; Nifedipine; Peptides; Pyridines; Rats; Species Specificity; Thiocyanates | 1987 |
The 165-kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Ion Channels; Isradipine; Kinetics; Molecular Weight; Muscles; Oxadiazoles; Pyridines; Rabbits; Receptors, Nicotinic; Verapamil | 1987 |
Interaction between calcium channel ligands and calcium channels.
Topics: Affinity Labels; Animals; Azides; Calcium; Chemical Phenomena; Chemistry; Dihydropyridines; Guinea Pigs; Ion Channels; Ligands; Male; Muscles; Myocardium; Rabbits; Receptors, Drug | 1987 |
Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; In Vitro Techniques; Ion Channels; Isradipine; Membrane Proteins; Molecular Weight; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma | 1987 |
Purification and reconstitution of calcium channel drug-receptor sites.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channels; Dihydropyridines; Guinea Pigs; Ion Channels; Muscles; Receptors, Drug; Receptors, Nicotinic; Verapamil | 1988 |
Binding of dihydropyridine calcium antagonists to membranes from human skeletal muscle.
Topics: Animals; Azides; Binding Sites; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Humans; In Vitro Techniques; Ion Channels; Isradipine; Muscle Proteins; Muscles; Oxadiazoles; Rabbits | 1988 |
Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood Proteins; Dihydropyridines; Epitopes; Humans; Immune Sera; KB Cells; Membrane Glycoproteins; Peptide Fragments; Serine Endopeptidases; Trypsin | 1989 |
Cytoplasmic orientation and two-domain structure of the multidrug transporter, P-glycoprotein, demonstrated with sequence-specific antibodies.
Topics: Affinity Labels; Amino Acid Sequence; Antibodies; Antigen-Antibody Complex; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood Proteins; Cytoplasm; Dihydropyridines; Epitopes; Fluorescent Antibody Technique; Humans; Immunoblotting; KB Cells; Membrane Glycoproteins; Models, Structural; Molecular Weight; Peptide Fragments; Trypsin | 1989 |
Molecular properties of voltage-activated calcium channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Azides; Calcium Channels; Cloning, Molecular; Dihydropyridines; DNA; Glycoproteins; Muscles; Phosphorylation; Protein Conformation; Protein Kinases; Receptors, Nicotinic; Verapamil | 1989 |
Is Ca2+ antagonists binding protein from cytosolic fraction the precursor of alpha 1-subunit of Ca2+ channel?
Topics: Affinity Labels; Animals; Antibodies; Azides; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cytoplasm; Dihydropyridines; In Vitro Techniques; Isradipine; Muscles; Oxadiazoles; Protein Precursors; Rabbits; Radioligand Assay; Receptors, Nicotinic; Ultraviolet Rays; Verapamil | 1989 |
Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line; Dihydropyridines; Drug Resistance; Endometrium; Estradiol; Female; Intracellular Membranes; Kinetics; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microsomes; Pregnancy; Pregnancy, Animal; Progesterone; Protein Binding; Steroids; Verapamil; Vinblastine | 1989 |
Analysis of structural features of dihydropyridine analogs needed to reverse multidrug resistance and to inhibit photoaffinity labeling of P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance; Humans; Membrane Glycoproteins; Photolysis; Structure-Activity Relationship; Tumor Cells, Cultured; Vincristine; Vindesine | 1989 |
Correlation between reversing of multidrug resistance and inhibiting of [3H]azidopine photolabeling of P-glycoprotein by newly synthesized dihydropyridine analogues in a human cell line.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Dihydropyridines; Drug Resistance; Humans; KB Cells; Membrane Glycoproteins; Molecular Weight; Structure-Activity Relationship; Vincristine | 1989 |
[A molecular basis for multidrug resistance and reversal of the resistance].
Topics: Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance; Humans; In Vitro Techniques; Membrane Glycoproteins; Neoplasms | 1989 |
Potentiation of some anticancer agents by dipyridamole against drug-sensitive and drug-resistant cancer cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line; Dactinomycin; Dihydropyridines; Dipyridamole; Drug Resistance; Drug Synergism; Fluorouracil; Humans; Membrane Glycoproteins; Tumor Cells, Cultured; Vincristine | 1989 |
3H-azidopine photoaffinity labeling of high molecular weight proteins in chloroquine resistant falciparum malaria.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Chloroquine; Chlorpromazine; Dihydropyridines; Drug Resistance; Glycoproteins; Molecular Weight; Nicardipine; Photochemistry; Plasmodium falciparum; Proteins; Quinacrine; Reserpine; Trifluoperazine; Verapamil | 1989 |
Photoaffinity-labelling of the calcium-channel-associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea-pig hippocampus. A 195 kDa polypeptide carries both drug receptors and has similarities to the alpha 1 subunit of the purified skeletal-m
Topics: Affinity Labels; Animals; Azides; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Guinea Pigs; Hippocampus; In Vitro Techniques; Kinetics; Muscles; Peptides; Radioimmunoassay; Receptors, Nicotinic; Tritium; Verapamil | 1988 |
Azidopine photoaffinity labeling of multidrug resistance-associated glycoproteins.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Calcium Channel Blockers; Dihydropyridines; Drug Resistance; Membrane Glycoproteins; Photolysis | 1988 |
Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Dihydropyridines; Isradipine; Molecular Weight; Muscles; Oxadiazoles; Photochemistry; Pyridines; Rabbits; Receptors, Nicotinic | 1987 |
Photoaffinity labelling of Ca2+ channels with [3H]azidopine.
Topics: Affinity Labels; Animals; Azides; Calcium; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Guinea Pigs; Ion Channels; Kinetics; Muscles; Photolysis; Pyridines; Tritium | 1984 |
Structure-activity relationship of verapamil analogs and reversal of multidrug resistance.
Topics: Animals; Antineoplastic Agents; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Calcium; Dihydropyridines; Doxorubicin; Drug Design; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Synergism; Humans; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Structure-Activity Relationship; Tumor Cells, Cultured; Tumor Stem Cell Assay; Verapamil | 1995 |
Identification of dihydropyridine (DHP) binding sites on cultured monkey renal cells (GMRC) with a photoaffinity probe (-)-[3H]-azidopine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Azides; Binding Sites; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Chlorocebus aethiops; Dihydropyridines; Kidney; Kinetics; Muscle Proteins; Nisoldipine; Nitrendipine; Propanolamines; Receptors, Adrenergic, beta | 1994 |
1,4-Dihydropyridine binding sites in moss plasma membranes. Properties of receptors for a calcium channel antagonist.
Topics: Azides; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cations, Divalent; Cell Membrane; Cytokinins; Dihydropyridines; Hydrogen-Ion Concentration; Kinetics; Oxidation-Reduction; Plant Development; Plants; Sulfhydryl Reagents; Temperature | 1995 |
Reconstitution of purified P-glycoprotein into liposomes.
Topics: Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Detergents; Dihydropyridines; Humans; Molecular Weight; Proteolipids; Vincristine | 1995 |
Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Membrane; Dihydropyridines; Furans; Humans; KB Cells; Phosphatidylethanolamines; Sensitivity and Specificity; Tritium; Vinblastine | 1995 |
B9209-005, an azido derivative of the chemosensitizer dexniguldipine-HCl, photolabels P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line; Dihydropyridines; Drug Resistance, Multiple; Drug Synergism; Humans; Photochemistry | 1995 |
Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Microscopy, Confocal; Microscopy, Fluorescence; Phenotype; Quinine; Subcellular Fractions; Tumor Cells, Cultured; Verapamil | 1995 |
Differential interaction of human renal P-glycoprotein with various metabolites and analogues of cyclosporin A.
Topics: Affinity Labels; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Line; Cyclosporine; Cyclosporins; Dihydropyridines; Drug Resistance, Multiple; Humans; Kidney; Male; Microvilli; Osmolar Concentration | 1995 |
Azelastine and flezelastine as reversing agents of multidrug resistance: pharmacological and molecular studies.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azepines; Azides; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Phthalazines; Rats; Tumor Cells, Cultured; Vincristine | 1995 |
Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro.
Topics: Animals; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; In Vitro Techniques; Propylamines; Rats; Stereoisomerism; Tiapamil Hydrochloride; Tumor Cells, Cultured; Verapamil; Vincristine | 1995 |
Differential modulation of P-glycoprotein transport by protein kinase inhibition.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carrier Proteins; Cyclosporine; Dactinomycin; Dihydropyridines; Drug Resistance; Humans; Isoenzymes; Membrane Glycoproteins; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1993 |
Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores.
Topics: Adenosine Triphosphatases; Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cell Membrane; CHO Cells; Cricetinae; Dihydropyridines; Enzyme Activation; Ionophores; Peptides; Photochemistry; Protein Binding; Verapamil | 1995 |
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Brain Chemistry; Cattle; Cell Membrane; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Dihydropyridines; Escherichia coli; Lipids; Liver; Proteolipids; Sheep; Verapamil; Vinblastine | 1995 |
Mechanism of action of dexniguldipine-HCl (B8509-035), a new potent modulator of multidrug resistance.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line; Cell Survival; Dihydropyridines; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Humans; Rhodamine 123; Rhodamines; Transfection; Vincristine | 1995 |
P-glycoprotein overexpression in mouse cells does not correlate with resistance to N-benzyladriamycin-14-valerate (AD 198).
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cells, Cultured; Dihydropyridines; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Immunoblotting; Mice; Tumor Cells, Cultured; Verapamil | 1994 |
Effects of nonionic detergents on P-glycoprotein drug binding and reversal of multidrug resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cells, Cultured; Cholic Acids; Detergents; Dihydropyridines; Drug Resistance; Humans; Membrane Glycoproteins; Octoxynol; Verapamil | 1993 |
Effect of tamoxifen on the multidrug-resistant phenotype in human breast cancer cells: isobologram, drug accumulation, and M(r) 170,000 glycoprotein (gp170) binding studies.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Breast Neoplasms; Carrier Proteins; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Drug Resistance; Female; Humans; Membrane Glycoproteins; Phenotype; Tamoxifen; Tumor Cells, Cultured; Vinblastine | 1994 |
Interaction of rat kidney P-glycoprotein with a urinary component and various drugs including cyclosporin A.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cyclosporine; Dihydropyridines; Drug Interactions; Drug Resistance; Female; Kidney Cortex; Male; Membrane Glycoproteins; Microvilli; Precipitin Tests; Rats; Tritium; Urine | 1994 |
Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.
Topics: 3T3 Cells; Affinity Labels; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cloning, Molecular; Dihydropyridines; DNA, Complementary; Drug Resistance; Glycine; Glycoside Hydrolases; Hot Temperature; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mutation; Protein Processing, Post-Translational | 1994 |
Alterations in Ca2+ transport ATPase and P-glycoprotein expression can mediate resistance to thapsigargin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Calcium-Transporting ATPases; Carrier Proteins; Cell Division; Cell Line; Cell Survival; Colchicine; Cricetinae; Cricetulus; Dactinomycin; Daunorubicin; Dihydropyridines; DNA, Complementary; Drug Resistance; Gene Expression; Lung; Membrane Glycoproteins; Mitotane; Multigene Family; Substrate Specificity; Terpenes; Thapsigargin; Transfection; Vincristine | 1994 |
Detection of oligomeric and monomeric forms of P-glycoprotein in multidrug resistant cells.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cell Compartmentation; Cell Line; Cell Membrane; Centrifugation; CHO Cells; Cricetinae; Dihydropyridines; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Humans; Membrane Glycoproteins | 1994 |
Effect of alpha-interferon on P-glycoprotein expression and function and on verapamil modulation of doxorubicin resistance.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Carrier Proteins; Cell Line; Cricetinae; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Synergism; Interferon-alpha; Membrane Glycoproteins; RNA, Messenger; Verapamil | 1994 |
Effect of newly synthesized indole derivatives on multidrug resistance in human cancer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Dihydropyridines; Drug Resistance; Humans; Indoles; KB Cells; Membrane Glycoproteins; Vincristine | 1994 |
Bile canalicular cationic dye secretion as a model for P-glycoprotein mediated transport.
Topics: Acridine Orange; Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Bile Canaliculi; Blotting, Western; Carrier Proteins; Cell Membrane; Cyclosporine; Dihydropyridines; In Vitro Techniques; Liver; Male; Membrane Glycoproteins; Models, Biological; Perfusion; Precipitin Tests; Rats; Rats, Inbred Strains; Verapamil | 1994 |
Modulation of P-glycoprotein by protein kinase C alpha in a baculovirus expression system.
Topics: Adenosine Triphosphatases; Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Baculoviridae; Base Sequence; Carrier Proteins; Cell Line; Dihydropyridines; DNA, Complementary; Drug Resistance; Gene Expression; Genetic Vectors; Humans; Isoenzymes; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Moths; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha | 1994 |
Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein.
Topics: 3T3 Cells; Adenosine Triphosphatases; Affinity Labels; Amino Acid Sequence; Amino Acids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane; Dihydropyridines; DNA, Complementary; Drug Resistance; Humans; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Photochemistry; Structure-Activity Relationship; Substrate Specificity | 1994 |
Comparison of mechanisms responsible for resistance to idarubicin and daunorubicin in multidrug resistant LoVo cell lines.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cell Membrane; Cell Nucleus; Clone Cells; Colonic Neoplasms; Daunorubicin; Dihydropyridines; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Fluorescence; Humans; Idarubicin; Tumor Cells, Cultured | 1994 |
Functional consequences of proline mutations in the predicted transmembrane domain of P-glycoprotein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Base Sequence; Cell Membrane; Cell Survival; Cloning, Molecular; Codon; Colchicine; Dactinomycin; Dihydropyridines; Doxorubicin; Drug Resistance; Gene Library; Humans; Kidney Cortex; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Proline; Protein Conformation; Recombinant Proteins; RNA, Messenger; Transfection; Tunicamycin; Vinblastine | 1993 |
Effect of anthracycline analogs on photolabelling of p-glycoprotein by [125I]iodomycin and [3H]azidopine: relation to lipophilicity and inhibition of daunorubicin transport in multidrug resistant cells.
Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Biological Transport; Carcinoma, Ehrlich Tumor; Daunorubicin; Detergents; Dihydropyridines; Doxorubicin; Drug Resistance; Iodine Radioisotopes; Membrane Glycoproteins; Photochemistry; Structure-Activity Relationship; Tritium; Tumor Cells, Cultured; Vincristine | 1993 |
Terfenadine (Seldane): a new drug for restoring sensitivity to multidrug resistant cancer cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Division; Dihydropyridines; Doxorubicin; Drug Resistance; Flupenthixol; Humans; Membrane Glycoproteins; Mice; Rhodamine 123; Rhodamines; Structure-Activity Relationship; Terfenadine; Tumor Cells, Cultured | 1993 |
Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Synergism; Female; Humans; In Vitro Techniques; Leukemia P388; Membrane Glycoproteins; Mice; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine | 1993 |
Non-glucocorticoid steroid analogues (21-aminosteroids) sensitize multidrug resistant cells to vinblastine.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Dihydropyridines; Drug Interactions; Drug Resistance; Humans; KB Cells; Membrane Glycoproteins; Pregnatrienes; Structure-Activity Relationship; Verapamil; Vinblastine | 1993 |
Expression of the multidrug transporter, P-glycoprotein, in renal and transitional cell carcinomas.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Renal Cell; Carcinoma, Transitional Cell; Carrier Proteins; Dihydropyridines; Drug Resistance; Humans; Immunoblotting; Kidney; Kidney Neoplasms; Membrane Glycoproteins; Neoplasm Proteins | 1993 |
Thaliblastine, a plant alkaloid, circumvents multidrug resistance by direct binding to P-glycoprotein.
Topics: Affinity Labels; Animals; Antineoplastic Agents, Phytogenic; Aporphines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Benzylisoquinolines; Carrier Proteins; Cell Cycle; Dihydropyridines; DNA, Neoplasm; Doxorubicin; Drug Resistance; Isoquinolines; Leukemia P388; Membrane Glycoproteins; Mice | 1993 |
P-glycoprotein-mediated transcellular transport of MDR-reversing agents.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Line; Cell Line, Transformed; Dihydropyridines; Diltiazem; Drug Resistance; Epithelium; Humans; Kinetics; Membrane Glycoproteins; Nitrendipine; Protein Kinase C; Staurosporine; Sucrose; Transfection; Tritium | 1993 |
Pharmacological characterization of N-substituted phenoxazines directed toward reversing Vinca alkaloid resistance in multidrug-resistant cancer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Carrier Proteins; Cell Survival; Dihydropyridines; Drug Interactions; Drug Resistance; Humans; KB Cells; Membrane Glycoproteins; Neoplasm Proteins; Oxazines; Protein Binding; Structure-Activity Relationship; Tumor Cells, Cultured; Vinca Alkaloids | 1993 |
Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carrier Proteins; Cell Membrane; Cloning, Molecular; Dihydropyridines; DNA; Drug Resistance; Humans; Kinetics; Membrane Glycoproteins; Mice; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Phenylalanine; Protein Structure, Secondary; Recombinant Proteins; Transfection; Vinblastine | 1993 |
Identification of 1,4-dihydropyridine binding domains within the primary structure of the alpha 1 subunit of the skeletal muscle L-type calcium channel.
Topics: Affinity Labels; Animals; Azides; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Muscle Proteins; Muscles; Peptide Fragments; Photochemistry; Rabbits; Tritium | 1993 |
Effects of modulators of cytosolic Ca2+ on phytohemagglutin-dependent Ca2+ response and interleukin-2 production in Jurkat cells.
Topics: Affinity Labels; Azides; Binding Sites; Calcium; Calcium Channel Blockers; Cytosol; Dihydropyridines; Gallic Acid; Glycoproteins; Humans; Interleukin-2; Isradipine; Kinetics; Nifedipine; Phytohemagglutinins; Ryanodine; T-Lymphocytes; Tumor Cells, Cultured | 1993 |
Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.
Topics: 3T3 Cells; Affinity Labels; Animals; Azides; Base Sequence; Colchicine; Cystic Fibrosis Transmembrane Conductance Regulator; Dihydropyridines; DNA Primers; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Fluoresceins; Fluorescent Dyes; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Recombinant Proteins; Spectrometry, Fluorescence; Transfection; Vinblastine; Vincristine | 1995 |
Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Chromatography, High Pressure Liquid; Dihydropyridines; Drug Resistance, Multiple; Humans; Oleic Acid; Oleic Acids; Structure-Activity Relationship; Surface-Active Agents; Tumor Cells, Cultured | 1996 |
Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol.
Topics: Animals; Antibiotics, Antineoplastic; Anticarcinogenic Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Melanoma, Experimental; Mice; Mice, Inbred Strains; Mice, Nude; Neoplasm Transplantation; Phenotype; Transfection; Tritium | 1996 |
Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-alpha pseudosubstrate peptide.
Topics: Affinity Labels; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Breast Neoplasms; Dihydropyridines; Drug Resistance, Multiple; Female; Humans; Isoenzymes; Molecular Sequence Data; Myristic Acid; Myristic Acids; Oligopeptides; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Tumor Cells, Cultured | 1996 |
Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein.
Topics: Adenosine Triphosphatases; Adrenal Glands; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Baculoviridae; Cell Line; Chlorpyrifos; Digestive System; Dihydropyridines; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Insecticides; Kidney; Liver; Male; Rats; Rats, Inbred F344 | 1996 |
Negative inotropic action of denbufylline through interfering with the calcium channel independently of its PDE IV inhibitory activity in guinea pig ventricle papillary muscles.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Azides; Caffeine; Calcium Channels; Depression, Chemical; Dihydropyridines; Guinea Pigs; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Papillary Muscles; Phosphodiesterase Inhibitors; Ryanodine; Sulfonamides; Xanthines | 1996 |
BIBW22 BS, potent multidrug resistance-reversing agent, binds directly to P-glycoprotein and accumulates in drug-resistant cells.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Cell Survival; CHO Cells; Colchicine; Cricetinae; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Kinetics; Lymphoma; Morpholines; Peptide Mapping; Protein Binding; Triamterene; Tumor Cells, Cultured; Verapamil; Vinblastine | 1996 |
Inhibition of P-glycoprotein-dependent multidrug resistance by an isoquinolinesulfonamide compound H-87 in rat ascites hepatoma AH66 cells.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Camptothecin; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Irinotecan; Isoquinolines; Protein Binding; Protein Kinase Inhibitors; Rats; Sulfonamides; Tritium; Tumor Cells, Cultured; Vinblastine | 1996 |
Effects of the selective bisindolylmaleimide protein kinase C inhibitor GF 109203X on P-glycoprotein-mediated multidrug resistance.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance, Multiple; Enzyme Inhibitors; Gene Expression; Humans; Indoles; Maleimides; Mice; Phosphorylation; Protein Kinase C; Verapamil | 1996 |
2-deoxy-D-glucose toxicity and transport in human multidrug-resistant KB carcinoma cell lines.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Blotting, Western; Colchicine; Deoxyglucose; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Phloretin; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1996 |
Cyclic AMP-dependent protein kinase but not protein kinase C regulates the cardiac Ca2+ channel through phosphorylation of its alpha 1 subunit.
Topics: Animals; Azides; Calcium; Calcium Channel Blockers; Calcium Channels; Cattle; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Heart Ventricles; Membrane Potentials; Membrane Proteins; Molecular Weight; Myocardium; Phosphoproteins; Phosphorylation; Protein Binding; Protein Kinase C; Proteolipids; Sarcolemma | 1996 |
Endothelin-1 significantly increased number of specific high-affinity 1,4-dihydropyridine (DHP) binding sites photolabelled on vascular smooth muscle cells with (-)-[3H]-azidopine.
Topics: Affinity Labels; Animals; Aorta, Thoracic; Azides; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Dihydropyridines; Endothelin-1; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Protein Kinase C; Rats; Staurosporine | 1996 |
Synthetic hydrophobic peptides are substrates for P-glycoprotein and stimulate drug transport.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; CHO Cells; Colchicine; Cricetinae; Dihydropyridines; Drug Resistance, Multiple; Kinetics; Leupeptins; Oligopeptides; Substrate Specificity; Vinblastine | 1996 |
Woodchuck p-glycoprotein found in virus-induced hepatocellular carcinomas binds anticancer drugs.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Carcinoma, Hepatocellular; Dihydropyridines; Doxorubicin; Liver Neoplasms; Marmota | 1996 |
Relationship between the inhibition of azidopine binding to P-glycoprotein by MDR modulators and their efficiency in restoring doxorubicin intracellular accumulation.
Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cyclosporine; Cyclosporins; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Mice; Nicardipine; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1996 |
Evidence that the organic cation/H+ exchanger in the brush border membrane of dog kidney is a 41-kDa protein.
Topics: Acridine Orange; Affinity Labels; Animals; Azides; Binding, Competitive; Carrier Proteins; Dihydropyridines; Dogs; Electrophoresis, Polyacrylamide Gel; Kidney Cortex; Kinetics; Macromolecular Substances; Microvilli; Molecular Weight; Substrate Specificity | 1997 |
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Survival; Cyclosporins; Dihydropyridines; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Humans; Neoplasm Proteins; Phenotype; Polymerase Chain Reaction; Prazosin; Rhodamine 123; Rhodamines; Sarcoma; Vault Ribonucleoprotein Particles; Verapamil | 1997 |
Binding and distribution of three prototype calcium channel blockers in perfused rat liver.
Topics: Animals; Azides; Calcium Channel Blockers; Calcium Channels; Carbon Radioisotopes; Dihydropyridines; Inulin; Isradipine; Liver; Models, Biological; Perfusion; Rats; Rats, Sprague-Dawley; Time Factors; Tritium; Urea; Verapamil | 1997 |
Reversal activity of cyclosporin A and its metabolites M1, M17 and M21 in multidrug-resistant cells.
Topics: Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane; Chromatography, High Pressure Liquid; Cyclosporine; Dihydropyridines; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Etoposide; Humans; Hydroxylation; Kinetics; Methylation; Molecular Structure; Paclitaxel; Photochemistry; Tumor Cells, Cultured | 1997 |
P-glycoprotein substrates and antagonists cluster into two distinct groups.
Topics: Adenosine Triphosphatases; Affinity Labels; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport, Active; Colonic Neoplasms; Cyclosporine; Dihydropyridines; Drug Interactions; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Immunosuppressive Agents; Rhodamines; Stimulation, Chemical; Substrate Specificity; Tritium; Tumor Cells, Cultured; Vinblastine | 1997 |
Function of P-glycoprotein expressed in placenta and mole.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Dihydropyridines; Drug Resistance, Multiple; Female; Humans; Hydatidiform Mole; Immunohistochemistry; KB Cells; Placenta; Pregnancy; Uterine Neoplasms; Vincristine | 1997 |
Inhibitory effect of alkylating modulators on the function of P-glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Breast Neoplasms; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flupenthixol; Fluphenazine; Humans; Tumor Cells, Cultured; Vinblastine | 1997 |
Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells.
Topics: Affinity Labels; Androstadienes; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; KB Cells; Penicillium; Vincristine | 1998 |
Identification of drug interaction sites in P-glycoprotein.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Line; Dihydropyridines; Drug Resistance, Multiple; Epitope Mapping; Humans; Iodine Radioisotopes; Radioisotope Dilution Technique; Tritium | 1998 |
Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.
Topics: Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane; Cloning, Molecular; Colchicine; Daunorubicin; Dihydropyridines; DNA-Directed RNA Polymerases; Drug Resistance, Multiple; Electrophoresis, Polyacrylamide Gel; Escherichia coli; HeLa Cells; Humans; Indicators and Reagents; Iodine Radioisotopes; Osteosarcoma; Plasmids; Polymerase Chain Reaction; Prazosin; Recombinant Proteins; Restriction Mapping; Transfection; Tritium; Tumor Cells, Cultured; Vaccinia virus; Vinblastine; Viral Proteins | 1998 |
Identification of the synthetic surfactant nonylphenol ethoxylate: a P-glycoprotein substrate in human urine.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Membrane Permeability; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Cyclosporine; Dihydropyridines; Dogs; Drug Resistance, Multiple; Ethylene Glycols; Humans; Magnetic Resonance Spectroscopy | 1998 |
Different effects of FK317 on multidrug-resistant tumor in vivo and in vitro.
Topics: Affinity Labels; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biotransformation; Carcinoma, Small Cell; Cell Survival; Dihydropyridines; Drug Resistance, Multiple; Humans; KB Cells; Lung Neoplasms; Male; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Oxazines; Transplantation, Heterologous; Tritium; Vinblastine | 1998 |
Selective inhibition of MDR1 P-glycoprotein-mediated transport by the acridone carboxamide derivative GG918.
Topics: Acridines; Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Bile; Daunorubicin; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Isoquinolines; Liver; Male; Neoplasm Proteins; Organelles; Photoaffinity Labels; Rats; Rats, Wistar; Taurocholic Acid; Tetrahydroisoquinolines | 1999 |
The bisindolylmaleimide protein kinase C inhibitor, Ro 32-2241, reverses multidrug resistance in KB tumour cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cell Survival; Daunorubicin; Dihydropyridines; DNA, Neoplasm; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Indoles; KB Cells; Maleimides; Protein Kinase C; Tumor Cells, Cultured | 1999 |
Ligand-mediated tertiary structure changes of reconstituted P-glycoprotein. A tryptophan fluorescence quenching analysis.
Topics: Acrylamide; Adenosine Triphosphate; Affinity Labels; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; CHO Cells; Cricetinae; Dihydropyridines; Drug Resistance, Multiple; Fluorescence; Ligands; Nucleotides; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Proteolipids; Tryptophan | 1999 |
Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cell Membrane; CHO Cells; Colchicine; Cricetinae; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Oligopeptides; Peptides; Photoaffinity Labels; Rhodamine 123; Tumor Cells, Cultured | 1999 |
Iodomycin and iodipine, a structural analogue of azidopine, bind to a common domain in hamster P-glycoprotein.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; CHO Cells; Cricetinae; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Humans; Iodine Radioisotopes; Iodobenzenes | 1999 |
Mechanism of inhibition of P-glycoprotein-mediated drug transport by protein kinase C blockers.
Topics: 3T3 Cells; Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Dihydropyridines; Enzyme Inhibitors; Humans; Mice; Phosphorylation; Protein Kinase C; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 1999 |
Reversal of acquired resistance to doxorubicin in K562 human leukemia cells by astemizole.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astemizole; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Colorimetry; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; K562 Cells; Photoaffinity Labels | 2000 |
Loss of cyclosporin and azidopine binding are associated with altered ATPase activity by a mutant P-glycoprotein with deleted phe(335).
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Calcium Channel Blockers; Cyclosporine; Dihydropyridines; Drug Interactions; Enzyme Activation; Humans; Molecular Sequence Data; Phenylalanine; Photoaffinity Labels; Tritium; Tumor Cells, Cultured; Vanadates; Verapamil | 2000 |
Localization of the 1,4-dihydropyridine drug acceptor of P-glycoprotein to a cytoplasmic domain using a permanently charged derivative N-methyl dexniguldipine.
Topics: Affinity Labels; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Azides; Binding Sites; Cell Division; Cell Membrane; Cells, Cultured; Dihydropyridines; Drug Interactions; Structure-Activity Relationship; Synaptic Vesicles; Vinblastine | 2000 |
Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cells, Cultured; Daunorubicin; Dihydropyridines; Doxorubicin; Drug Interactions; Drug Resistance, Neoplasm; Humans; Itraconazole; Photoaffinity Labels; Swine; Transfection; Tritium; Vinblastine | 1999 |
The novel anticancer drug KRN5500 interacts with, but is hardly transported by, human P-glycoprotein.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Cell Division; Dihydropyridines; Humans; Photoaffinity Labels; Purine Nucleosides; Swine | 2000 |
Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Calcium Channel Blockers; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; K562 Cells; Piperazines; Rhodamine 123 | 2000 |
Enhancement of doxorubicin activity in multidrug-resistant cells by mefloquine.
Topics: Affinity Labels; Antibiotics, Antineoplastic; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Calcium Channel Blockers; Coloring Agents; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mefloquine; Phenotype; Rhodamine 123; Tumor Cells, Cultured; Verapamil | 2000 |
Reversal of P-glycoprotein and multidrug-resistance protein-mediated drug resistance in KB cells by 5-O-benzoylated taxinine K.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Azides; Biological Transport; Bridged-Ring Compounds; Dihydropyridines; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glutathione; Humans; KB Cells; Leukotriene C4; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organelles; Paclitaxel; Photoaffinity Labels; Plants, Medicinal; Taxoids; Taxus; Tritium; Vault Ribonucleoprotein Particles | 2000 |
Reversal of multidrug resistance by 7-O-benzoylpyripyropene A in multidrug-resistant tumor cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Squamous Cell; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; KB Cells; Pyridones; Sesquiterpenes; Tumor Cells, Cultured; Vincristine | 2000 |
In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576.
Topics: Acridines; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Cyclosporins; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Isoquinolines; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Paclitaxel; Quinolines; Tetrahydroisoquinolines; Time Factors; Treatment Outcome; Tritium; Xenograft Model Antitumor Assays | 2001 |
Reversal of vinblastine resistance in human leukemic cells by haloperidol and dihydrohaloperidol.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Drug Resistance, Neoplasm; Drug Synergism; Haloperidol; Humans; Leukemia; Photoaffinity Labels; Tumor Cells, Cultured; Vinblastine | 2001 |
Indoloquinoxaline compounds that selectively antagonize P-glycoprotein.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Cisplatin; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Photoaffinity Labels; Quinoxalines; Toxicity Tests; Tumor Cells, Cultured; Vinblastine | 2000 |
Impact of the basic amine on the biological activity and intracellular distribution of an aza-anthrapyrazole: BBR 3422.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cell Division; Dihydropyridines; DNA; Drug Interactions; Drug Resistance, Multiple; Electrophoresis, Agar Gel; Humans; Indazoles; Isoquinolines; Photoaffinity Labels; Subcellular Fractions; Tritium; Tumor Cells, Cultured | 2001 |
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Baculoviridae; Binding Sites; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Cysteine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; Kinetics; Mutagenesis; Nicardipine; Photoaffinity Labels; Serine; Spodoptera; Vinblastine | 2001 |
Characterization of the dexniguldipine binding site in the multidrug resistance-related transport protein P-glycoprotein by photoaffinity labeling and mass spectrometry.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Chromatography, High Pressure Liquid; Dihydropyridines; Humans; Mass Spectrometry; Peptide Fragments; Photoaffinity Labels; Tritium; Trypsin; Tumor Cells, Cultured | 2002 |
Reversal of P-glycoprotein-mediated multidrug resistance by ginsenoside Rg(3).
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Dihydropyridines; Disease Models, Animal; Drug Resistance, Multiple; Fluorescent Dyes; Ginsenosides; Humans; KB Cells; Leukemia P388; Mice; Rhodamine 123; Tritium; Tumor Cells, Cultured; Vinblastine | 2003 |
Transition state P-glycoprotein binds drugs and modulators with unchanged affinity, suggesting a concerted transport mechanism.
Topics: Adenosine Diphosphate; Anilino Naphthalenesulfonates; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Benzimidazoles; Biological Transport; CHO Cells; Cobalt; Cricetinae; Dihydropyridines; Doxorubicin; Magnesium; Pharmaceutical Preparations; Photoaffinity Labels; Protein Binding; Spectrometry, Fluorescence; Tryptophan; Vanadates; Vinblastine | 2003 |
Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport.
Topics: Adenosine Triphosphatases; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Daunorubicin; Dihydropyridines; Doxorubicin; Drug Interactions; Flavonoids; Genistein; Humans; Phloretin; Photoaffinity Labels; Silymarin; Time Factors; Transfection; Tritium; Tumor Cells, Cultured | 2003 |
RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance.
Topics: 3T3 Cells; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Enzyme Inhibitors; Mice; Mifepristone; Vinblastine | 2003 |
Novel plant triterpenoid drug amooranin overcomes multidrug resistance in human leukemia and colon carcinoma cell lines.
Topics: Affinity Labels; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma; Cell Cycle; Cell Survival; Colonic Neoplasms; Dihydropyridines; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia; Triterpenes; Tumor Cells, Cultured | 2003 |
The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1).
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Cells, Cultured; Dihydropyridines; Disulfiram; Drug Interactions; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Hydrolysis; Mice; Multidrug Resistance-Associated Proteins; Phosphorus Radioisotopes; Prazosin | 2004 |
Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Azides; Benzimidazoles; Binding, Competitive; Celastraceae; Cell Membrane; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Kinetics; Liposomes; Membrane Transport Modulators; Membrane Transport Proteins; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; NIH 3T3 Cells; Photoaffinity Labels; Protein Binding; Sesquiterpenes; Substrate Specificity; Vinblastine | 2004 |
Schisandrin B--a novel inhibitor of P-glycoprotein.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line, Tumor; Cell Proliferation; Cyclooctanes; Daunorubicin; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; Models, Chemical; Neoplasms; Polycyclic Compounds; Protein Binding; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Calcium Channel Blockers; Cell Line; Chlorophyll; Dihydropyridines; Drug Interactions; Humans; Mitoxantrone; Neoplasm Proteins; Nicardipine; Nifedipine; Photoaffinity Labels; Prazosin | 2006 |
Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin.
Topics: Adenosine Triphosphate; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azides; Biological Transport; Chlorophyll; Curcumin; Dihydropyridines; Drug Resistance, Neoplasm; Humans; Hydrolysis; Mitoxantrone; Mutation; Neoplasm Proteins; Prazosin; Toxicity Tests; Tumor Cells, Cultured | 2006 |