Compounds > azelnidipine
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azelnidipine and olmesartan medoxomil

azelnidipine has been researched along with olmesartan medoxomil in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cui, TX; Horiuchi, M; Iwai, M; Jinno, T; Li, JM; Li, Z; Liu, HW; Ogihara, T; Rakugi, H1
Iwao, H; Izumi, Y; Izumiya, Y; Kim-Mitsuyama, S; Yoshida, K; Yoshiyama, M1
Horiuchi, M; Ide, A; Iwai, M; Li, JM; Li, Z; Min, LJ; Mogi, M; Oshita, A; Suzuki, J; Yoshii, T1
Arakawa, K; Kuramoto, K; Tanigawara, Y; Yoshihara, K1
Kuramoto, K; Ogihara, T; Saruta, T; Shimada, K2
Hirooka, Y; Kishi, T; Ogawa, K; Shinohara, K; Sunagawa, K; Utsumi, H; Yasukawa, K1
Furusu, A; Kohno, S; Koji, T; Miyazaki, T; Nishino, T; Obata, Y; Sato, Y; Uramatsu, T1
Asai, S; Nakayama, T; Nishida, Y; Susa, N; Takahashi, Y; Yada, Y1

Trials

3 trial(s) available for azelnidipine and olmesartan medoxomil

ArticleYear
Comparative pharmacodynamics of olmesartan and azelnidipine in patients with hypertension: a population pharmacokinetic/pharmacodynamic analysis.
    Drug metabolism and pharmacokinetics, 2009, Volume: 24, Issue:4

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Azetidinecarboxylic Acid; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Clinical Laboratory Techniques; Cross-Over Studies; Dihydropyridines; Female; Humans; Hypertension; Imidazoles; Individuation; Male; Middle Aged; Olmesartan Medoxomil; Population Groups; Tetrazoles

2009
A randomized, double-blind, four-arm parallel-group study of the efficacy and safety of azelnidipine and olmesartan medoxomil combination therapy compared with each monotherapy in Japanese patients with essential hypertension: the REZALT study.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:12

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Asian People; Azetidinecarboxylic Acid; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypertension; Imidazoles; Male; Middle Aged; Olmesartan Medoxomil; Tetrazoles; Treatment Outcome

2009
Effects of combination olmesartan medoxomil plus azelnidipine versus monotherapy with either agent on 24-hour ambulatory blood pressure and pulse rate in Japanese patients with essential hypertension: additional results from the REZALT study.
    Clinical therapeutics, 2010, Volume: 32, Issue:5

    Topics: Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Azetidinecarboxylic Acid; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Dihydropyridines; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Imidazoles; Male; Middle Aged; Olmesartan Medoxomil; Tetrazoles

2010

Other Studies

6 other study(ies) available for azelnidipine and olmesartan medoxomil

ArticleYear
Calcium channel blocker azelnidipine enhances vascular protective effects of AT1 receptor blocker olmesartan.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:2

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Occlusive Diseases; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cell Division; Dihydropyridines; Drug Synergism; Drug Therapy, Combination; Imidazoles; Inflammation; Male; MAP Kinase Signaling System; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Olmesartan Medoxomil; Oxidative Stress; Receptor, Angiotensin, Type 1; Tetrazoles; Tunica Intima

2004
Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2004, Volume: 27, Issue:10

    Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Azetidinecarboxylic Acid; Calcium Channel Blockers; Cardiac Output, Low; Creatinine; Dihydropyridines; Drug Combinations; Echocardiography; Gene Expression; Hypertension; Imidazoles; Myocardium; Olmesartan Medoxomil; Organ Size; Rats; Rats, Inbred Dahl; Survival Analysis; Tetrazoles; Thiazepines

2004
Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice.
    Journal of hypertension, 2005, Volume: 23, Issue:7

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoproteins E; Arteriosclerosis; Azetidinecarboxylic Acid; Blotting, Western; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Imidazoles; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NADPH Oxidases; Olmesartan Medoxomil; Oxidative Stress; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Superoxides; Tetrazoles; Time Factors

2005
Combination therapy of olmesartan and azelnidipine inhibits sympathetic activity associated with reducing oxidative stress in the brain of hypertensive rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2012, Volume: 34, Issue:6

    Topics: Animals; Antihypertensive Agents; Azetidinecarboxylic Acid; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Drug Therapy, Combination; Hypertension; Imidazoles; Male; Olmesartan Medoxomil; Oxidative Stress; Rats; Rats, Inbred SHR; Tetrazoles

2012
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine.
    Biological & pharmaceutical bulletin, 2013, Volume: 36, Issue:8

    Topics: Animals; Antihypertensive Agents; Azetidinecarboxylic Acid; Calcium Channel Blockers; Chemokine CCL2; Dihydropyridines; Hypertension; Imidazoles; Inhibitor of Apoptosis Proteins; Kidney; Lipoproteins, LDL; Macrophages; Male; Nephrosclerosis; Olmesartan Medoxomil; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Scavenger; Tetrazoles

2013
Comparative effect of fixed-dose combination tablets of candesartan cilexetil/amlodipine versus olmesartan medoxomil/azelnidipine on laboratory parameters in patients with hypertension: a retrospective cohort study.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2016, Volume: 38, Issue:2

    Topics: Aged; Alanine Transaminase; Amlodipine; Antihypertensive Agents; Aspartate Aminotransferases; Azetidinecarboxylic Acid; Benzimidazoles; Biphenyl Compounds; Blood Urea Nitrogen; Cohort Studies; Creatinine; Dihydropyridines; Drug Combinations; Female; Glomerular Filtration Rate; Humans; Hypertension; Male; Middle Aged; Olmesartan Medoxomil; Potassium; Propensity Score; Retrospective Studies; Sodium; Tetrazoles; Uric Acid

2016