azathioprine has been researched along with 6-thioguanylic acid in 103 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (7.77) | 18.7374 |
| 1990's | 10 (9.71) | 18.2507 |
| 2000's | 29 (28.16) | 29.6817 |
| 2010's | 48 (46.60) | 24.3611 |
| 2020's | 8 (7.77) | 2.80 |
| Authors | Studies |
|---|---|
| Lennard, L; Van Loon, JA; Weinshilboum, RM | 1 |
| Amess, J; Amos, R; Lennard, L; Maddocks, JL; Thomas, RM | 1 |
| Lennard, L; Lilleyman, JS; Van Loon, JA; Weinshilboum, RM | 1 |
| Harrington, CI; Lennard, L; Maddocks, JL; Thomas, S | 1 |
| Lennard, L; Maddocks, JL | 1 |
| Brown, CB; Fox, M; Lennard, L; Maddocks, JL | 1 |
| Lennard, L; Maddocks, JL; Murphy, MF | 1 |
| Dooley, T; Maddocks, JL | 1 |
| Lipsky, JJ; Mays, DC; Sandborn, WJ; Tremaine, WJ; Van O, EC; Zins, BJ | 1 |
| Bentdal, O; Bergan, S; Rugstad, HE; Stokke, O | 1 |
| Kriegbaum, NJ; Schmiegelow, K | 1 |
| Aarbakke, J; Bentdal, O; Bergan, S; Hartmann, A; Klemetsdal, B; Rugstad, HE; Stokke, O; Sødal, G | 1 |
| Armstrong, VW; Gummert, J; Mohr, FW; Oellerich, M; Schütz, E | 1 |
| Boulieu, R | 1 |
| Aarbakke, J; Bentdal, O; Bergan, S; Giverhaug, T; Hartmann, A; Klemetsdal, B; Rugstad, HE; Stokke, O; Sødal, G | 1 |
| Aziz, T; Campbell, C; Deiraniya, A; el-Gamel, A; Evans, C; Keevil, B; Rahman, A; Yonan, N | 1 |
| Bentdal, O; Bergan, S; Hartmann, A; Leivestad, T; Rugstad, HE; Stokke, O; Sødal, G | 1 |
| Baudouin, V; Broly, F; Dervieux, T; Jacqz-Aigrain, E; Loirat, C; Maisin, A; Médard, Y; Zhang, D | 1 |
| Bertocchi, M; Boulieu, R; Dervieux, T; Gallant, I; Mornex, JF; Sauviat, M | 1 |
| Desager, JP; Dewit, O; Horsmans, Y; Vanheuverzwyn, R | 1 |
| Franklin, CL; Lipsky, JJ; Lowry, PW; Mays, DC; Myhre, GM; Sandborn, WJ; Thomas, CW; Tremaine, WJ; Weaver, AL | 1 |
| Bessard, G; Bonaz, B; Phelip, JM; Roblin, X; Serre-Debeauvais, F | 1 |
| Larsen, NE; Reuther, LO; Sonne, J; Vainer, B | 1 |
| Dubinsky, MC | 1 |
| Griffiths, AM | 1 |
| Bayless, TM; Cuffari, C; Dassopoulos, T; Thompson, RE; Turnbough, L | 1 |
| Hindorf, U; Lyrenäs, E; Nilsson, A; Schmiegelow, K | 1 |
| Rumbo, C | 1 |
| Al Hadithy, AF; Brouwers, JR; de Boer, NK; Derijks, LJ; Escher, JC; Mulder, CJ | 1 |
| Hibi, T; Hisamatsu, T | 1 |
| Barclay, ML; Gearry, RB | 1 |
| Barham, R; Barry, M; Boulieu, R; Dervieux, T; Matsutani, M; Meyer, G; Neri, B; Seidman, E | 1 |
| Barclay, ML; Florkowski, CM; Gearry, RB; George, PM; Harraway, J; Pike, LS; Roberts, RL; Zhang, M | 1 |
| Eichelbaum, M; Fischer, C; Galle, PR; Hofmann, U; Kiesslich, R; Neurath, MF; Schwab, M; Teichgräber, U | 1 |
| Dejaco, C; Harrer, M; Mantl, M; Miehsler, W; Reinisch, W; Schaeffeler, E; Schneider, B; Schwab, M; Teml, A; Vogelsang, H | 1 |
| de Boer, NK; Mulder, CJ; van Bodegraven, AA | 1 |
| Bentue-Ferrer, D; Branger, B; Bretagne, JF; D'Halluin, PN; Heresbach, D; Lebreton, C; Tribut, O | 1 |
| Bongartz, TA; Gödde, A; Lang, B; Müller-Ladner, U; Schedel, J; Schölmerich, J; Schütz, E | 1 |
| Banerjee, S; Bishop, WP | 1 |
| Dilger, K; Herfarth, H; Lukas, M; Müller, R; Schaeffeler, E; Schwab, M; Strauch, U | 1 |
| Bentue-Ferrer, D; Bridoux-Henno, L; Cagnard, B; Dabadie, A; Delaperriere, N; Moizard, C; Tosoni-Verlingue, D; Tribut, O | 1 |
| Adler, G; Armstrong, VW; Behrens, C; Bias, P; Herfarth, H; Kruis, W; Oellerich, M; Reinshagen, M; Schütz, E; Shipkova, M; Stallmach, A; Stein, J; von Ahsen, N; von Tirpitz, C | 1 |
| Devlin, SM; Kwan, LY; Mirocha, JM; Papadakis, KA | 1 |
| Baldassano, RN; Davis, CM; Hommel, KA | 1 |
| Cairns, C; Collier, PS; Collins, J; Dempsey, S; Hawwa, AF; McCarthy, A; McElnay, JC; Millership, JS; Rodgers, C; Vandenbroeck, K | 1 |
| Barclay, ML; Burt, MJ; Ding, SL; Gardiner, SJ; Gearry, RB | 1 |
| Beppu, T; Hirai, F; Hisabe, T; Ishihara, H; Maki, S; Matsui, T; Murakami, Y; Nagahama, T; Takaki, Y; Takatsu, N; Yao, K | 1 |
| Aoyagi, Y; Arai, K; Baba, Y; Fujii, T; Ikuse, T; Inage, E; Kudo, T; Nagata, S; Ohtani, K; Ohtsuka, Y; Shimizu, T; Suzuki, R; Yamakawa, Y | 1 |
| Bartoli, F; Campanozzi, A; Decorti, G; Londero, M; Malusa, N; Marino, S; Martelossi, S; Stocco, G; Ventura, A | 1 |
| Beránek, M; Chládek, J; Dědek, P; Hroch, M; Krásničanová, P; Malý, J; Pozler, O | 1 |
| Barclay, ML; Burt, MJ; Chalmers-Watson, T; Chapman, BA; Gardiner, SJ; Gearry, RB; Huelsen, A; Ross, AG; Stedman, CA | 1 |
| Abreu, L; Algaba, A; Benito, LM; Bermejo, F; Bujanda, L; Cabriada, JL; Calvo, M; Cara, C; Carneros, JA; Carpio, D; Casellas, F; Esteve, M; Froilan, C; García-Fernández, FJ; García-Sánchez, V; Ginard, D; Gisbert, JP; González-Lama, Y; López-Sanromán, A; Manceñido, N; Maté, J; McNicholl, AG; Merino, O; Muñoz, C; Pajares, R; Ricart, E; Velasco, M; Vera, MI | 1 |
| Armstrong, L; Bishop, J; Galloway, P; McGrogan, P; Russell, RK; Sharif, JA | 1 |
| Angelberger, S; Heinkele, G; Hofmann, U; Jaeger, S; Lichtenberger, C; Reinisch, W; Schaeffeler, E; Schwab, M | 1 |
| Bakker, JA; Bierau, J; Bos, LP; Bus, P; Engels, LG; Gilissen, LP; Hooymans, PM; Masclee, AA; Neef, C; Paulussen, AD; Romberg-Camps, MJ; Stockbrügger, RW; Stronkhorst, A; Wong, DR | 1 |
| Barclay, ML; Chin, P; Sies, CW; van Egmond, R; Zhang, M | 1 |
| Bi, HC; Chen, BL; Chen, MH; Ding, L; Gao, X; Hu, PJ; Huang, M; Liu, H; Wang, XD; Xiao, YL; Zhang, FB; Zhao, LZ | 1 |
| Caufield, M; Tom, WL | 1 |
| Bouma, G; de Boer, NK; Losekoot, N; Mulder, CJ; Peters, GJ; Seinen, ML; Smid, K; van Asseldonk, DP; van Bodegraven, AA | 1 |
| Angelberger, S; Bar-Meir, S; Dilger, K; Greinwald, R; Herrlinger, KR; Lukas, M; Mueller, R; Petritsch, W; Reinisch, W; Schaeffeler, E; Schwab, M; Shonova, O; Stange, EF; Teml, A | 1 |
| de Boer, NK; de Jong, DJ; Dijkstra, G; Hommes, DW; Jharap, B; Mulder, CJ; Oldenburg, B; Stokkers, P; van Bodegraven, AA; van der Woude, CJ; van Elburg, RM | 1 |
| Boulieu, R; Lachaux, A; Nguyen, TM; Nguyen, TV; Vu, DH | 1 |
| Curkovic, I; Frei, P; Fried, M; Jetter, A; Kullak-Ublick, GA; Rentsch, KM; Rogler, G | 1 |
| Bakker, JA; Bus, P; Engels, LG; Gilissen, LP; Hooymans, PM; Masclee, AA; Neef, C; Pierik, M; Seinen, ML; van Bodegraven, AA; Wong, DR | 1 |
| Bégin, J; Doré, M; Frenette, AJ; Mansour, AM; Troyanov, Y | 1 |
| Beaune, P; Chatellier, G; Chouchana, L; Golmard, JL; Loriot, MA; Narjoz, C; Pineau, B; Roche, D | 1 |
| Amre, D; Deslandres, C; Kopylov, U; Seidman, EG; Theoret, Y | 1 |
| Choe, YH; Kim, MJ; Lee, SY | 1 |
| Battat, R; Benmassaoud, A; Kopylov, U; Paradis-Surprenant, L; Seidman, EG | 1 |
| Choe, YH; Choi, SY; Kang, B; Kim, JW; Kim, MJ; Lee, MN; Lee, SY; Woo, SY | 2 |
| Bouma, G; de Boer, NK; Kreijne, JE; Mulder, CJ; Seinen, ML; van Bodegraven, AA; Wilhelm, AJ | 1 |
| Asher, R; Collins, P; Dibb, M; Jackson, R; Kneebone, A; Poon, SS; Probert, C; Subramanian, S | 1 |
| Ito, Z; Kobayashi, H; Koido, S; Kubota, T; Odahara, S; Ohkusa, T; Saito, K; Takami, S; Uchiyama, K | 1 |
| Begun, J | 1 |
| Burke, G; Pinto, A; Rae, W | 1 |
| Baili, C; Fangbin, Z; Feng, X; Hui, L; Huichang, B; Liang, D; Lizi, Z; Min, H; Minhu, C; Peng, C; Pinjin, H; Xiang, G; Xueding, W; Yanjun, C; Yinglian, X | 1 |
| Han, W; Hu, J; Hu, N; Liu, Q; Mei, Q; Wang, Y | 1 |
| Borowiec, A; Dadlez, M; Hryniewiecka, E; Jazwiec, R; Paczek, L; Samborowska, E; Tszyrsznic, W; Zegarska, J; Zochowska, D | 1 |
| Gong, X; Li, X; Liu, Y; Mei, S; Yang, L; Zhang, X; Zhao, Z; Zhou, A; Zhou, H; Zhu, L | 1 |
| Bouma, G; de Boer, NKH; Meijer, B; Mulder, CJJ; van Bodegraven, AA; Wilhelm, AJ | 1 |
| Boulieu, R; Citterio-Quentin, A; Gustin, MP; Moulsma, M | 1 |
| Christensen, B; Cohen, RD; Gondal, B; Hirsch, A; Rubin, DT; Yarur, AJ | 1 |
| Esaki, M; Hibi, T; Hisamatsu, T; Ishida, T; Kanai, T; Kato, S; Matsui, T; Matsumoto, T; Motoya, S; Nagahori, M; Naito, Y; Nakagawa, T; Nakase, H; Nojima, M; Suzuki, Y; Watanabe, K; Watanabe, M; Yoshimura, N | 1 |
| Bruijnzeel-Koomen, CAF; de Bruin-Weller, MS; de Graaf, M; Garritsen, FM; van den Broek, MPH; van der Schaft, J; van Schaik, RH | 1 |
| Bouvy, ML; Broekman, MMTJ; Coenen, MJH; de Jong, DJ; Derijks, LJJ; Guchelaar, HJ; Hooymans, PM; Kievit, W; Klungel, OH; Scheffer, H; van Marrewijk, CJ; Verbeek, ALM; Wanten, GJ; Wong, DR | 1 |
| Bruijnzeel-Koomen, CAF; De Bruin-Weller, MS; de Graaf, M; Garritsen, FM; Hijnen, DJ; van den Broek, MPH; van der Schaft, J | 1 |
| Ainsworth, MA; Brynskov, J; Mogensen, DV; Nersting, J; Schmiegelow, K; Steenholdt, C | 1 |
| Andrews, JM; Baird, A; Bampton, P; Barclay, ML; Bell, SJ; Gearry, RB; Grafton, R; Halliwell, J; Jones, GT; Kennedy, MA; Krishnaprasad, K; Lawrance, IC; McHugh, PC; Prosser, R; Radford-Smith, G; Roberts, RL; Seinen, ML; Simms, LA; Studd, C; van Bodegraven, AA; van Rij, AM; Wallace, MC | 1 |
| Ben-Horin, S; Chen, BL; Chen, MH; Guo, J; He, Y; Luber, R; Mao, R; Roblin, X; Sparrow, MP; Zeng, ZR | 1 |
| Ben-Horin, S; Chen, MH; Chowers, Y; Eliakim, R; Fudim, E; Gueta, I; Kopylov, U; Loebstein, R; Mao, R; Markovits, N; Peled, Y; Picard, O; Ungar, B; Van Assche, G; Yavzori, M | 1 |
| Bachmann, O; Essmann, J; Keil, C; Manns, MP; Otte, A; Unruh, O | 1 |
| Bolia, R; Hardikar, W; Rajanayagam, J | 1 |
| Adler, J; Eder, SJ; Kandavel, P; Newman, NE; Waljee, AK; Whitfield, EP | 1 |
| Atanasovska, E; Gjatovska, LL; Gjorgjievska, K; Kikerkov, I; Pavlovska, K; Petrushevska, M; Ribarska, JT; Zendelovska, D | 1 |
| Bai, YJ; Li, Y; Miao, Q; Su, ZZ; Wang, LL; Yan, L; Zhang, JL; Zou, YG | 1 |
| Czaja, AJ | 1 |
| Dawson, L; Gibson, PR; Kariyawasam, VC; Luber, RP; Martin, C; Munari, S; Sparrow, MP; Ward, MG | 1 |
| Dong, J; Huang, P; Jiao, Z; Lin, C; Lin, R; Lin, W; Liu, Y; Wang, C; Zeng, D; Zheng, W | 1 |
| Benninga, MA; Buiter, HJC; de Boer, NKH; de Meij, TGJ; Jagt, JZ; Pothof, CD; van Limbergen, JE; van Wijk, MP | 1 |
| Bai, Y; Li, Y; Miao, Q; Wang, L; Yan, L; Zhang, J; Zhou, Y; Zou, Y | 1 |
| Anderson, S; Ansari, AR; Bayoumy, AB; Boekema, PJ; Derijks, LJJ; Loganayagam, A; Mulder, CJJ; Sanderson, JD | 1 |
| Ge, W; Jin, L; Luo, X; Yan, S; Zhang, X; Zhu, H | 1 |
4 review(s) available for azathioprine and 6-thioguanylic acid
| Article | Year |
|---|---|
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
Topics: Antimetabolites; Azathioprine; Gene Frequency; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Inosine Triphosphatase; Mercaptopurine; Methyltransferases; Phenotype; Practice Guidelines as Topic; Pyrophosphatases; Racial Groups; Thionucleotides | 2005 |
[Immunosuppressants for therapy of patients with ulcerative colitis].
Topics: Azathioprine; Colitis, Ulcerative; Cyclosporine; Drug Therapy, Combination; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Methyltransferases; Mycophenolic Acid; Tacrolimus; Thionucleotides | 2005 |
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Bone Marrow; Erythrocytes; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Inosine Triphosphatase; Mercaptopurine; Methyltransferases; Polymorphism, Genetic; Pyrophosphatases; Thionucleotides | 2005 |
Review article: opportunities to improve and expand thiopurine therapy for autoimmune hepatitis.
Topics: Allopurinol; Azathioprine; Drug-Related Side Effects and Adverse Reactions; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Inflammatory Bowel Diseases; Mercaptopurine; Purines; Quality Improvement; Thioguanine; Thionucleotides; Treatment Outcome | 2020 |
16 trial(s) available for azathioprine and 6-thioguanylic acid
| Article | Year |
|---|---|
An intravenous loading dose of azathioprine decreases the time to response in patients with Crohn's disease.
Topics: Adult; Aged; Azathioprine; Crohn Disease; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infusions, Intravenous; Male; Methyltransferases; Middle Aged; Remission Induction; Thionucleotides; Time Factors | 1995 |
Optimization of azathioprine therapy by measuring 6-thioguanine nucleotides and methylated mercaptopurine in renal allograft recipients.
Topics: Azathioprine; Erythrocytes; Graft Rejection; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Mercaptopurine; Methyltransferases; Prospective Studies; Thionucleotides | 1995 |
Effect of allopurinol on the metabolism of azathioprine in heart transplant patients.
Topics: Allopurinol; Azathioprine; Erythrocytes; Graft Rejection; Guanine Nucleotides; Heart Transplantation; Humans; Immunosuppressive Agents; Regression Analysis; Thionucleotides | 1998 |
Monitored high-dose azathioprine treatment reduces acute rejection episodes after renal transplantation.
Topics: Adolescent; Adult; Aged; Azathioprine; Bone Marrow; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Graft Rejection; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Leukocyte Count; Male; Middle Aged; Neutrophils; Thionucleotides | 1998 |
Interaction between azathioprine and aminosalicylates: an in vivo study in patients with Crohn's disease.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Biomarkers; Crohn Disease; Drug Interactions; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mesalamine; Methyltransferases; Middle Aged; Sulfasalazine; Thionucleotides | 2002 |
Erythrocyte mean corpuscular volume as a surrogate marker for 6-thioguanine nucleotide concentration monitoring in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Biomarkers; Endpoint Determination; Erythrocyte Indices; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukocyte Count; Male; Mercaptopurine; Middle Aged; Severity of Illness Index; Surveys and Questionnaires; Thionucleotides; Treatment Outcome | 2003 |
A prospective, open-label trial of 6-thioguanine in patients with ulcerative or indeterminate colitis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Azathioprine; Biomarkers; C-Reactive Protein; Colitis, Ulcerative; Dose-Response Relationship, Drug; Endoscopy, Gastrointestinal; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methylthioinosine; Methyltransferases; Middle Aged; Orosomucoid; Patient Compliance; Prospective Studies; Quality of Life; Thioguanine; Thionucleotides; Treatment Outcome | 2005 |
Impact of thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations in patients with chronic inflammatory diseases.
Topics: Adult; Aged; Azathioprine; Chronic Disease; Cohort Studies; Female; Guanine Nucleotides; Humans; Inflammation; Male; Methyltransferases; Middle Aged; Sensitivity and Specificity; Thionucleotides | 2006 |
Monitoring of thiopurine methyltransferase activity in postsurgical patients with Crohn's disease during 1 year of treatment with azathioprine or mesalazine.
Topics: Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Crohn Disease; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Monitoring; Female; Gene Frequency; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Mesalamine; Methyltransferases; Middle Aged; Phenotype; Postoperative Period; Prospective Studies; Thioguanine; Thionucleotides; Time Factors | 2007 |
6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Crohn Disease; Dose-Response Relationship, Drug; Erythrocyte Indices; Female; Genotype; Guanine Nucleotides; Humans; Leukopenia; Male; Mercaptopurine; Methyltransferases; Middle Aged; Remission Induction; Thionucleotides; Thrombocytopenia | 2007 |
Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease.
Topics: Adult; Antimetabolites, Antineoplastic; Azathioprine; Female; Forecasting; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Thionucleotides; Treatment Outcome | 2008 |
Therapeutic drug monitoring of thiopurine metabolites in adult thiopurine tolerant IBD patients on maintenance therapy.
Topics: Adolescent; Adult; Aged; Azathioprine; Biomarkers, Pharmacological; Chromatography, High Pressure Liquid; Cross-Sectional Studies; Disease Progression; Dose-Response Relationship, Drug; Drug Monitoring; Female; Genetic Markers; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Maintenance Chemotherapy; Male; Medication Adherence; Mercaptopurine; Methyltransferases; Middle Aged; Prospective Studies; Severity of Illness Index; Thioinosine; Thionucleotides; Young Adult | 2012 |
Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anemia, Neonatal; Azathioprine; Biomarkers; Female; Fetal Blood; Follow-Up Studies; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infant, Newborn; Inflammatory Bowel Diseases; Mercaptopurine; Middle Aged; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Thionucleotides; Treatment Outcome; Young Adult | 2014 |
Low allopurinol doses are sufficient to optimize azathioprine therapy in inflammatory bowel disease patients with inadequate thiopurine metabolite concentrations.
Topics: Adult; Aged; Allopurinol; Azathioprine; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides | 2013 |
Significance of measurement of serum trough level and anti-drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohn's disease: a subanalysis of the DIAMOND trial.
Topics: Adalimumab; Anti-Inflammatory Agents; Antibodies; Crohn Disease; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Sensitivity and Specificity; Thionucleotides; Treatment Outcome | 2017 |
Patients' beliefs about medicine are associated with early thiopurine discontinuation in patients with inflammatory bowel diseases.
Topics: Adult; Female; Guanine Nucleotides; Health Knowledge, Attitudes, Practice; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Medication Adherence; Mercaptopurine; Middle Aged; Surveys and Questionnaires; Thioinosine; Thionucleotides; Treatment Outcome; Young Adult | 2018 |
83 other study(ies) available for azathioprine and 6-thioguanylic acid
| Article | Year |
|---|---|
Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism.
Topics: Adult; Azathioprine; Bone Marrow; Erythrocytes; Female; Guanine Nucleotides; Humans; Male; Methyltransferases; Middle Aged; Polymorphism, Genetic; Thionucleotides | 1989 |
Azathioprine and severe bone marrow depression.
Topics: Acute Disease; Azathioprine; Bone Marrow Diseases; Female; Guanine Nucleotides; Humans; Middle Aged; Thionucleotides | 1986 |
Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations.
Topics: Adult; Azathioprine; Child; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Leukemia, Lymphoid; Male; Methyltransferases; Risk; Thionucleotides | 1987 |
Skin cancer in renal transplant recipients is associated with increased concentrations of 6-thioguanine nucleotide in red blood cells.
Topics: Adult; Azathioprine; Carcinoma, Squamous Cell; Drug Administration Schedule; Erythrocytes; Female; Guanine Nucleotides; Humans; Keratosis; Kidney Transplantation; Male; Middle Aged; Photosensitivity Disorders; Skin Neoplasms; Thionucleotides | 1985 |
Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells.
Topics: Azathioprine; Erythrocytes; Guanine Nucleotides; Humans; In Vitro Techniques; Leukemia, Lymphoid; Mercaptopurine; Thioguanine; Thionucleotides | 1983 |
Azathioprine metabolism in kidney transplant recipients.
Topics: Adult; Allopurinol; Azathioprine; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Individuality; Kidney Transplantation; Leukocyte Count; Leukopenia; Male; Sex Factors; Thionucleotides | 1984 |
Severe megaloblastic anaemia associated with abnormal azathioprine metabolism.
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Azathioprine; Guanine Nucleotides; Humans; Male; Middle Aged; Thionucleotides | 1984 |
Assay of an active metabolite of 6-thioguanine, 6-thioguanosine 5'-monophosphate, in human red blood cells.
Topics: Azathioprine; Chromatography, Liquid; Erythrocytes; Guanine Nucleotides; Humans; Reference Values; Thioguanine; Thionucleotides | 1982 |
Monitoring of azathioprine treatment by determination of 6-thioguanine nucleotide concentrations in erythrocytes.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Creatinine; Drug Monitoring; Erythrocytes; Female; Graft Rejection; Guanine Nucleotides; Humans; Kidney Transplantation; Male; Middle Aged; Thionucleotides | 1994 |
6-Thioguanine nucleotide accumulation in erythrocytes during azathioprine treatment for systemic connective tissue diseases: a possible index for monitoring treatment.
Topics: Adult; Aged; Azathioprine; Connective Tissue Diseases; Erythrocytes; Evaluation Studies as Topic; Female; Guanine Nucleotides; Humans; Male; Middle Aged; Retrospective Studies; Thionucleotides | 1993 |
Azathioprine pharmacogenetics: the relationship between 6-thioguanine nucleotides and thiopurine methyltransferase in patients after heart and kidney transplantation.
Topics: Azathioprine; Chromatography, High Pressure Liquid; DNA; Erythrocytes; Female; Guanine Nucleotides; Heart Transplantation; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Methyltransferases; Pharmacogenetics; Polymorphism, Genetic; Radioimmunoassay; Thionucleotides; White People; Xanthine Oxidase | 1996 |
Sample preparation for the determination of purine nucleotide analogues in tissues.
Topics: Antimetabolites; Azathioprine; Chromatography, High Pressure Liquid; Ganciclovir; Guanine Nucleotides; Guanosine Triphosphate; Heart Transplantation; Humans; Inosine Monophosphate; Lung; Myocardium; Purine Nucleotides; Specimen Handling; Thionucleotides | 1996 |
Possibilities for therapeutic drug monitoring of azathioprine: 6-thioguanine nucleotide concentrations and thiopurine methyltransferase activity in red blood cells.
Topics: Adolescent; Adult; Aged; Azathioprine; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Methyltransferases; Middle Aged; Thionucleotides | 1997 |
Thiopurine methyltransferase activity and its relationship to the occurrence of rejection episodes in paediatric renal transplant recipients treated with azathioprine.
Topics: Antimetabolites; Azathioprine; Child; Chromatography, High Pressure Liquid; Female; Genotype; Graft Rejection; Guanine Nucleotides; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Methyltransferases; Prodrugs; Thionucleotides | 1999 |
Methylated and non methylated thiopurine nucleotide ratio (Me6-MPN/6-TGN): usefulness in the monitoring of azathioprine therapy?
Topics: Adult; Azathioprine; DNA Methylation; Dose-Response Relationship, Drug; Erythrocytes; Female; Guanine Nucleotides; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Middle Aged; Monitoring, Physiologic; Thionucleotides | 2000 |
Drug interaction between infliximab and azathioprine in patients with Crohn's disease.
Topics: Adolescent; Adult; Antibodies, Monoclonal; Antimetabolites; Azathioprine; Crohn Disease; Drug Interactions; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Infliximab; Leukocyte Count; Liver Function Tests; Male; Middle Aged; Prospective Studies; Thionucleotides; Treatment Outcome | 2003 |
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.
Topics: Adjuvants, Immunologic; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Female; Genotype; Guanine Nucleotides; Humans; Male; Mercaptopurine; Methyltransferases; Middle Aged; Mutation; Polymerase Chain Reaction; Thionucleotides | 2004 |
Monitoring of AZA/6-MP treatment in children with IBD is necessary.
Topics: Azathioprine; Child; Drug Monitoring; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methylthioinosine; Methyltransferases; Polymorphism, Genetic; Thionucleotides | 2003 |
Monitoring of azathioprine/6-mercaptopurine treatment in children with IBD is not necessary.
Topics: Azathioprine; Child; Drug Monitoring; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methylthioinosine; Methyltransferases; Polymorphism, Genetic; Thionucleotides | 2003 |
Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease.
Topics: Adult; Azathioprine; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Logistic Models; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Remission Induction; Thionucleotides; Treatment Outcome | 2004 |
Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Drug Monitoring; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Sulfasalazine; Thionucleotides | 2004 |
Azathioprine metabolite measurements: its use in current clinical practice.
Topics: Azathioprine; Guanine Nucleotides; Humans; Monitoring, Physiologic; Thionucleotides | 2004 |
Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy.
Topics: Adult; Azathioprine; Chromatography, Liquid; Cohort Studies; Drug Therapy, Combination; Erythrocytes; Female; Genetic Variation; Guanine Nucleotides; Humans; Hydrolysis; Inflammatory Bowel Diseases; Male; Mass Spectrometry; Mercaptopurine; Methyltransferases; Purine Nucleotides; Thionucleotides | 2005 |
Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.
Topics: Azathioprine; Biomarkers; Erythrocytes; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Mercaptopurine; Methyltransferases; Thionucleotides | 2005 |
6-thioguanosine diphosphate and triphosphate levels in red blood cells and response to azathioprine therapy in Crohn's disease.
Topics: Adult; Antibodies, Monoclonal; Azathioprine; Biomarkers; Crohn Disease; Erythrocytes; Guanine Nucleotides; Guanosine Diphosphate; Humans; Immunosuppressive Agents; Infliximab; Thionucleotides | 2005 |
Myelotoxicity and hepatotoxicity during azathioprine therapy.
Topics: Adult; Azathioprine; Biopsy; Blood Platelets; Bone Marrow; Crohn Disease; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocytes; Liver; Liver Cirrhosis; Male; Thionucleotides | 2005 |
RBC 6-TGN and hematological parameters in patients with Crohn's disease treated by azathioprine.
Topics: Adult; Azathioprine; Blood Cell Count; Crohn Disease; Erythrocyte Indices; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Neutrophils; Thionucleotides | 2005 |
Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Erythrocytes; Female; Guanine Nucleotides; Heterozygote; Humans; Infant; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prednisone; Remission Induction; Retrospective Studies; Thionucleotides | 2006 |
[Advantages of different dosages of active metabolites in the follow-up of azathioprine treatment for Crohn disease].
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Crohn Disease; Female; Follow-Up Studies; Guanine Nucleotides; Humans; Male; Thionucleotides | 2006 |
Medication adherence and quality of life in pediatric inflammatory bowel disease.
Topics: Adolescent; Anti-Inflammatory Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Depression; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Guanine Nucleotides; Humans; Illness Behavior; Male; Medication Adherence; Mercaptopurine; Mesalamine; Quality of Life; Thionucleotides | 2008 |
Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine.
Topics: Adolescent; Antimetabolites, Antineoplastic; Azathioprine; Child; Child, Preschool; Female; Gene Frequency; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Pharmacogenetics; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thionucleotides; Treatment Outcome | 2008 |
Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides.
Topics: Adult; Azathioprine; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Middle Aged; Thionucleotides | 2008 |
Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease.
Topics: Adult; Alopecia; Aminosalicylic Acids; Anti-Inflammatory Agents; Asian People; Azathioprine; Chemical and Drug Induced Liver Injury; Communicable Diseases; Female; Gastrointestinal Agents; Gastrointestinal Diseases; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Japan; Leukopenia; Liver Diseases; Male; Methyltransferases; Phenotype; Polymorphism, Genetic; Predictive Value of Tests; Retrospective Studies; Thionucleotides; Young Adult | 2009 |
Monitoring 6-thioguanine nucleotide concentrations in Japanese children and adolescents with inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Biomarkers, Pharmacological; Child; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Drug Monitoring; Female; Follow-Up Studies; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Japan; Male; Mercaptopurine; Remission Induction; Retrospective Studies; Thionucleotides; Treatment Outcome | 2010 |
Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Medication Adherence; Mercaptopurine; Thionucleotides; Young Adult | 2010 |
Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease.
Topics: Adolescent; Azathioprine; Child; Child, Preschool; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides; Treatment Outcome | 2010 |
Allopurinol might improve response to azathioprine and 6-mercaptopurine by correcting an unfavorable metabolite ratio.
Topics: Adult; Allopurinol; Anti-Inflammatory Agents; Azathioprine; Biotransformation; Drug Therapy, Combination; Enzyme Inhibitors; Erythrocyte Count; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; New Zealand; Red-Cell Aplasia, Pure; Retrospective Studies; Steroids; Thionucleotides; Time Factors; Treatment Outcome; Xanthine Oxidase | 2011 |
Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients.
Topics: Adolescent; Adult; Aged; Area Under Curve; Azathioprine; Biomarkers; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Prospective Studies; ROC Curve; Thionucleotides; Treatment Outcome; Young Adult | 2011 |
Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine.
Topics: Adolescent; Azathioprine; Biomarkers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Retrospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2011 |
Simultaneous quantification of eleven thiopurine nucleotides by liquid chromatography-tandem mass spectrometry.
Topics: Azathioprine; Chromatography, High Pressure Liquid; Crohn Disease; Erythrocytes; Guanine Nucleotides; Humans; Immunosuppressive Agents; Isotope Labeling; Mercaptopurine; Methylthioinosine; Tandem Mass Spectrometry; Thionucleotides | 2012 |
High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.
Topics: Antimetabolites, Antineoplastic; Azathioprine; Chromatography, High Pressure Liquid; Drug Resistance; Erythrocyte Membrane; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Statistics as Topic; Thioguanine; Thionucleotides | 2012 |
The potential influence of 5-aminosalicylic acid on the induction of myelotoxicity during thiopurine therapy in inflammatory bowel disease patients.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Asian People; Azathioprine; Bone Marrow; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infant; Inflammatory Bowel Diseases; Male; Mercaptopurine; Mesalamine; Methyltransferases; Middle Aged; Prospective Studies; Retrospective Studies; Thionucleotides; Young Adult | 2012 |
Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring.
Topics: Administration, Oral; Adolescent; Azathioprine; Child; Child, Preschool; Dermatitis, Atopic; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Prospective Studies; Severity of Illness Index; Thionucleotides | 2013 |
The effect of allopurinol and low-dose thiopurine combination therapy on the activity of three pivotal thiopurine metabolizing enzymes: results from a prospective pharmacological study.
Topics: Adult; Allopurinol; Azathioprine; Drug Therapy, Combination; Enzyme Activation; Enzyme Inhibitors; Fatigue; Female; Guanine Nucleotides; Humans; Hypoxanthine Phosphoribosyltransferase; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Nausea; Prospective Studies; Thioinosine; Thionucleotides; Xanthine Oxidase | 2013 |
Mucosal improvement in patients with moderate to severe postoperative endoscopic recurrence of Crohn's disease and azathioprine metabolite levels.
Topics: Adolescent; Adult; Aged; Azathioprine; Biomarkers; Crohn Disease; Drug Administration Schedule; Drug Monitoring; Endoscopy, Gastrointestinal; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Intestinal Mucosa; Male; Middle Aged; Recurrence; ROC Curve; Severity of Illness Index; Thioguanine; Thioinosine; Thionucleotides; Treatment Outcome; Young Adult | 2013 |
Relationship between azathioprine dosage and thiopurine metabolites in pediatric IBD patients: identification of covariables using multilevel analysis.
Topics: Adolescent; Age Factors; Azathioprine; Child; Dose-Response Relationship, Drug; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Multilevel Analysis; Retrospective Studies; Thionucleotides | 2013 |
The pharmacokinetic effect of adalimumab on thiopurine metabolism in Crohn's disease patients.
Topics: Adalimumab; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Azathioprine; C-Reactive Protein; Crohn Disease; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Guanine Nucleotides; Humans; Hypoxanthine Phosphoribosyltransferase; Immunosuppressive Agents; Inosine Triphosphatase; Male; Methyltransferases; Middle Aged; Prospective Studies; Pyrophosphatases; Severity of Illness Index; Thioinosine; Thionucleotides; Young Adult | 2014 |
Febuxostat as a novel option to optimize thiopurines' metabolism in patients with inadequate metabolite levels.
Topics: Adult; Azathioprine; Drug Interactions; Enzyme Inhibitors; Febuxostat; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Mercaptopurine; Muscular Diseases; Thiazoles; Thionucleotides; Xanthine Oxidase | 2014 |
Interindividual variability in TPMT enzyme activity: 10 years of experience with thiopurine pharmacogenetics and therapeutic drug monitoring.
Topics: Adult; Azathioprine; Databases, Factual; Drug Monitoring; Female; Genotype; Guanine Nucleotides; Humans; Individuality; Male; Methyltransferases; Middle Aged; Pharmacogenetics; Phenotype; Retrospective Studies; Thioguanine; Thioinosine; Thionucleotides; Young Adult | 2014 |
Thiopurine metabolite ratios for monitoring therapy in pediatric Crohn disease.
Topics: Adolescent; Azathioprine; Chemical and Drug Induced Liver Injury; Child; Crohn Disease; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Methyltransferases; Odds Ratio; Thionucleotides; Treatment Failure | 2014 |
Monitoring thiopurine metabolites in korean pediatric patients with inflammatory bowel disease.
Topics: Adolescent; Adult; Azathioprine; Child; Child, Preschool; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Methyltransferases; Republic of Korea; Risk Factors; Thionucleotides; Treatment Outcome | 2014 |
Hematologic indices as surrogate markers for monitoring thiopurine therapy in IBD.
Topics: Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; Erythrocyte Indices; Female; Guanine Nucleotides; Hematologic Tests; Hemoglobins; Humans; Lymphocyte Count; Male; Mercaptopurine; Platelet Count; Predictive Value of Tests; Retrospective Studies; Thionucleotides; Treatment Outcome | 2015 |
Relationship between azathioprine dosage, 6-thioguanine nucleotide levels, and therapeutic response in pediatric patients with IBD treated with azathioprine.
Topics: Adolescent; Azathioprine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Methyltransferases; Polymerase Chain Reaction; Prognosis; Retrospective Studies; Thionucleotides | 2015 |
Routinely Established Skewed Thiopurine Metabolism Leads to a Strikingly High Rate of Early Therapeutic Failure in Patients With Inflammatory Bowel Disease.
Topics: Adolescent; Adult; Aged; Azathioprine; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Female; Follow-Up Studies; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Retrospective Studies; Risk Factors; Thioinosine; Thionucleotides; Treatment Failure; Young Adult | 2015 |
Body Mass Index and Smoking Affect Thioguanine Nucleotide Levels in Inflammatory Bowel Disease.
Topics: Adult; Azathioprine; Biomarkers; Body Mass Index; Colitis, Ulcerative; Crohn Disease; Drug Administration Schedule; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Linear Models; Male; Mercaptopurine; Middle Aged; Obesity; Retrospective Studies; Smoking; Thionucleotides; Treatment Outcome | 2015 |
Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Crohn Disease; Dose-Response Relationship, Drug; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukopenia; Male; Mesalamine; Methyltransferases; Polymorphism, Genetic; Retrospective Studies; Thionucleotides | 2015 |
A Prospective Study Evaluating Metabolic Capacity of Thiopurine and Associated Adverse Reactions in Japanese Patients with Inflammatory Bowel Disease (IBD).
Topics: Adult; Alleles; Azathioprine; Erythrocytes; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Incidence; Inflammatory Bowel Diseases; Japan; Leukopenia; Male; Methyltransferases; Middle Aged; Mutation; Pharmacogenetics; Prospective Studies; Pyrophosphatases; Thionucleotides; Young Adult | 2015 |
Inflammatory bowel disease in the clinic: Escalation and de-escalation of therapy: A longitudinal case-based discussion.
Topics: Adolescent; Azathioprine; Crohn Disease; Drug Substitution; Drug Therapy, Combination; Enteral Nutrition; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infliximab; Lymphoma, T-Cell; Male; Methotrexate; Recurrence; Remission Induction; Thionucleotides | 2016 |
A study of the utility of azathioprine metabolite testing in myasthenia gravis.
Topics: Adult; Aged; Aged, 80 and over; Azathioprine; Cell Count; Cohort Studies; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Lymphocytes; Male; Middle Aged; Myasthenia Gravis; Severity of Illness Index; Statistics as Topic; Thionucleotides | 2016 |
Prospective Evaluation of Pharmacogenomics and Metabolite Measurements upon Azathioprine Therapy in Inflammatory Bowel Disease: An Observational Study.
Topics: Adult; Aged; Azathioprine; China; Drug Monitoring; Female; Genetic Testing; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukopenia; Male; Methyltransferases; Middle Aged; Pharmacogenetics; Predictive Value of Tests; Prospective Studies; Thionucleotides | 2016 |
Measurement of red blood cell 6-thioguanine nucleotide is beneficial in azathioprine maintenance therapy of Chinese Crohn's disease patients.
Topics: Adult; Azathioprine; Crohn Disease; Drug Monitoring; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Leukopenia; Male; Methyltransferases; Prospective Studies; Thionucleotides; Young Adult | 2016 |
Determination of Concentrations of Azathioprine Metabolites 6-Thioguanine and 6-Methylmercaptopurine in Whole Blood With the Use of Liquid Chromatography Combined With Mass Spectrometry.
Topics: Adult; Azathioprine; Chromatography, Liquid; Erythrocytes; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Male; Mercaptopurine; Organ Transplantation; Tandem Mass Spectrometry; Thioguanine; Thionucleotides | 2016 |
LC-MS/MS Analysis of Erythrocyte Thiopurine Nucleotides and Their Association With Genetic Variants in Patients With Neuromyelitis Optica Spectrum Disorders Taking Azathioprine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Azathioprine; Child; Chromatography, Liquid; Erythrocytes; Female; Genetic Variation; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Middle Aged; Neuromyelitis Optica; Nucleotides; Polymorphism, Genetic; Tandem Mass Spectrometry; Thionucleotides; Young Adult | 2017 |
Pharmacology of Thiopurine Therapy in Inflammatory Bowel Disease and Complete Blood Cell Count Outcomes: A 5-Year Database Study.
Topics: Adult; Blood Cell Count; Databases, Factual; Drug Monitoring; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Thionucleotides; Time Factors; Treatment Outcome | 2017 |
ITPA Activity in Adults and Children Treated With or Without Azathioprine: Relationship Between TPMT Activity, Thiopurine Metabolites, and Co-medications.
Topics: Adolescent; Adult; Aged; Azathioprine; Child; Child, Preschool; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infant; Male; Methyltransferases; Middle Aged; Phenotype; Pyrophosphatases; Retrospective Studies; Thioinosine; Thionucleotides; Young Adult | 2017 |
Higher Thioguanine Nucleotide Metabolite Levels are Associated With Better Long-term Outcomes in Patients With Inflammatory Bowel Diseases.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis, Ulcerative; Crohn Disease; Digestive System Surgical Procedures; Drug Monitoring; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Longitudinal Studies; Male; Mercaptopurine; Middle Aged; Predictive Value of Tests; Recurrence; Remission Induction; Retrospective Studies; Thionucleotides; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2018 |
Thiopurine metabolite levels in patients with atopic dermatitis and/or chronic hand/foot eczema treated with azathioprine.
Topics: Adult; Azathioprine; Chromatography, High Pressure Liquid; Dermatitis, Atopic; Eczema; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Thionucleotides; Treatment Outcome | 2018 |
Allopurinol Co-prescription Improves the Outcome of Azathioprine Treatment in Chronic Eczema.
Topics: Adult; Allopurinol; Azathioprine; Chronic Disease; Dermatitis, Atopic; Drug Therapy, Combination; Eczema; Female; Foot Dermatoses; Guanine Nucleotides; Hand Dermatoses; Humans; Immunosuppressive Agents; Male; Mercaptopurine; Middle Aged; Prospective Studies; Thionucleotides; Time Factors; Treatment Outcome | 2018 |
A Role for Thiopurine Metabolites in the Synergism Between Thiopurines and Infliximab in Inflammatory Bowel Disease.
Topics: Adult; Antibodies; Drug Synergism; Drug Therapy, Combination; Erythrocytes; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Infliximab; Male; Mercaptopurine; Methyltransferases; Middle Aged; Retrospective Studies; Thionucleotides | 2018 |
Nonsynonymous Polymorphism in Guanine Monophosphate Synthetase Is a Risk Factor for Unfavorable Thiopurine Metabolite Ratios in Patients With Inflammatory Bowel Disease.
Topics: Adult; Azathioprine; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cohort Studies; Female; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Mercaptopurine; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thionucleotides; Young Adult | 2018 |
6-Thioguanine Nucleotide Levels Are Associated With Mucosal Healing in Patients With Crohn's Disease.
Topics: Adolescent; Adult; Australia; Azathioprine; Biomarkers; China; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; Endoscopy, Gastrointestinal; Female; France; Guanine Nucleotides; Humans; Immunosuppressive Agents; Linear Models; Male; Mucous Membrane; Multivariate Analysis; Retrospective Studies; ROC Curve; Thioguanine; Thionucleotides; Young Adult | 2018 |
Pharmacokinetics and Immune Reconstitution Following Discontinuation of Thiopurine Analogues: Implications for Drug Withdrawal Strategies.
Topics: Adult; Azathioprine; Bacterial Toxins; Cell Proliferation; Enterotoxins; Female; Guanine Nucleotides; Humans; Immune Reconstitution; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Metabolic Clearance Rate; Muromonab-CD3; Superantigens; T-Lymphocytes; Thionucleotides; Withholding Treatment | 2018 |
Fecal calprotectin is significantly linked to azathioprine metabolite concentrations in Crohn's disease.
Topics: Adult; Anti-Inflammatory Agents; Azathioprine; Biomarkers; Crohn Disease; Cross-Sectional Studies; Drug Monitoring; Erythrocytes; Feces; Female; Gastrointestinal Agents; Guanine Nucleotides; Humans; Intestinal Mucosa; Leukocyte L1 Antigen Complex; Longitudinal Studies; Male; Middle Aged; Predictive Value of Tests; Retrospective Studies; Thionucleotides; Time Factors; Treatment Outcome; Wound Healing | 2019 |
Lower 6-MMP/6-TG Ratio May Be a Therapeutic Target in Pediatric Autoimmune Hepatitis.
Topics: Allopurinol; Antimetabolites; Azathioprine; Child; Female; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Liver Function Tests; Maintenance Chemotherapy; Male; Mercaptopurine; Retrospective Studies; Thionucleotides; Treatment Outcome | 2018 |
Mean Corpuscular Volume to White Blood Cell Ratio for Thiopurine Monitoring in Pediatric Inflammatory Bowel Disease.
Topics: Adolescent; Area Under Curve; Azathioprine; C-Reactive Protein; Child; Colitis, Ulcerative; Crohn Disease; Cross-Sectional Studies; Erythrocyte Indices; Feces; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Leukocyte Count; Leukocyte L1 Antigen Complex; Male; Mercaptopurine; Predictive Value of Tests; Retrospective Studies; ROC Curve; Severity of Illness Index; Thionucleotides; Young Adult | 2019 |
Importance of 6-Thioguanine Nucleotide Metabolite Monitoring in Inflammatory Bowel Disease Patients Treated with Azathioprine.
Topics: Adult; Azathioprine; Drug Monitoring; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Middle Aged; Prospective Studies; Thionucleotides; Time Factors | 2019 |
Highly sensitive and rapid determination of azathioprine metabolites in whole blood lysate by liquid chromatography-tandem mass spectrometry.
Topics: Adult; Azathioprine; Chromatography, High Pressure Liquid; Drug Monitoring; Female; Guanine Nucleotides; Humans; Limit of Detection; Linear Models; Male; Methylthioinosine; Middle Aged; Reproducibility of Results; Tandem Mass Spectrometry; Thionucleotides | 2020 |
Thiopurines and their optimization during infliximab induction and maintenance: A retrospective study in Crohn's disease.
Topics: Azathioprine; Biomarkers; Crohn Disease; Drug Therapy, Combination; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Infliximab; Maintenance Chemotherapy; Male; Mercaptopurine; Remission Induction; Retrospective Studies; Thionucleotides; Treatment Outcome | 2021 |
Population pharmacokinetics of azathioprine active metabolite in patients with inflammatory bowel disease and dosage regimens optimisation.
Topics: Adolescent; Adult; Azathioprine; Female; Genotype; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Male; Methyltransferases; Middle Aged; Models, Biological; Polymorphism, Single Nucleotide; Pyrophosphatases; Thionucleotides; Young Adult | 2021 |
Adverse Events of Thiopurine Therapy in Pediatric Inflammatory Bowel Disease and Correlations with Metabolites: A Cohort Study.
Topics: Adolescent; Antimetabolites; Azathioprine; Biomarkers, Pharmacological; Child; Cohort Studies; Colitis, Ulcerative; Crohn Disease; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; Guanine Nucleotides; Humans; Male; Mercaptopurine; Netherlands; Retrospective Studies; Thionucleotides; Withholding Treatment | 2022 |
Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.
Topics: Adult; Aged; Alleles; Azathioprine; China; Female; Genetic Association Studies; Guanine Nucleotides; Hepatitis, Autoimmune; Humans; Leukopenia; Male; Methyltransferases; Middle Aged; Mutation; Phenotype; Pyrophosphatases; Thionucleotides | 2021 |
Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine.
Topics: Adult; Azathioprine; Female; Genotype; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mercaptopurine; Methyltransferases; Middle Aged; Phenotype; Retrospective Studies; Thioguanine; Thionucleotides | 2021 |
Inosine Triphosphate Pyrophosphatase and NUDT15 are Good Predictors of Clinical Outcomes in Thiopurine-Treated Chinese Patients with Inflammatory Bowel Disease.
Topics: Azathioprine; Biomarkers; China; Guanine Nucleotides; Humans; Inflammatory Bowel Diseases; Leukopenia; Methyltransferases; Prognosis; Pyrophosphatases; Thionucleotides | 2022 |