azacitidine has been researched along with trichostatin a in 508 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (0.98) | 18.2507 |
| 2000's | 269 (52.95) | 29.6817 |
| 2010's | 227 (44.69) | 24.3611 |
| 2020's | 7 (1.38) | 2.80 |
| Authors | Studies |
|---|---|
| Chiba, DE; Dos Santos, JL; Lopes, JR | 1 |
| Bailey, EC; Chen, WY; Dong, JY; McCune, SL; Townes, TM | 1 |
| Chen, ZJ; Pikaard, CS | 1 |
| Bachman, KE; Baylin, SB; Cameron, EE; Herman, JG; Myöhänen, S | 1 |
| Coffee, B; Reines, D; Warren, ST; Zhang, F | 1 |
| Asch, BB; Asch, HL; Head, KL; Mielnicki, LM; Ying, AM | 1 |
| Li, J; Noguchi, CT; Schechter, AN; Smith, RD | 1 |
| Kim, HS; Lee, JY; Park, J; Park, JB; Shin, JY | 1 |
| Ferguson, AT; Orlandi, R; Sacchi, N; Sirchia, SM; Sironi, E; Subramanyan, S; Sukumar, S | 1 |
| Brooks, CG; Brown, AR; Chrzanowska-Lightowlers, ZM; Fraser, KP; Gays, F; Shrestha, S; Tristram, CM; Unnikrishnan, M | 1 |
| Lowrey, CH; McInerney, JM; Nawrocki, JR | 1 |
| Chen, C; Yang, MC; Yang, TP | 1 |
| Bouhassira, EE; Feng, YQ; Fiering, S; Greally, JM; Lorincz, MC | 1 |
| Hirokawa, Y; Ito, H; Mizokami, A; Nakayama, T; Sekita, N; Shiraishi, T; Suzuki, H; Toyota, M; Watanabe, M; Yatani, R | 1 |
| Beal, MD; Lakshmanan, RR; Otterson, GA; Zhu, WG | 1 |
| Ding, BC; Heng, H; Hukku, B; Matherly, LH; Witt, TL; Zhang, L | 1 |
| Magdinier, F; Wolffe, AP | 1 |
| Pontoglio, M; Viollet, B; Yaniv, M | 1 |
| Albritton, WL; Cabrera-Juárez, E; Setlow, JK | 1 |
| Bashambu, M; Singal, R; van Wert, J | 1 |
| Gorelik, E; Huang, X; Li, M; Orucevic, A | 1 |
| Cho, JH; Hattori, N; Kimura, H; Minami, T; Ohgane, J; Shiota, K; Tanaka, S | 1 |
| Bovenzi, V; Momparler, RL | 1 |
| Akakura, K; Ichikawa, T; Igarashi, T; Ito, H; Kito, H; Nakayama, T; Sekita, N; Shiraishi, T; Suzuki, H; Toyota, M; Watanabe, M; Yoshie, O | 1 |
| Davidson, NE; Ferguson, AT; Herman, JG; Nelson, WG; Phillips, DL; Yang, X | 1 |
| Stimson, KM; Vertino, PM | 1 |
| Fujita, M; Hosokawa, M; Imai, K; Itoh, F; Kikuchi, T; Suzuki, H; Toyota, M; Yamamoto, H | 1 |
| Horton, Y; Roddie, PH; Turner, ML | 1 |
| Danbara, M; Higashihara, M; Kameyama, K; Takagaki, Y | 1 |
| Bharadwaj, S; Prasad, GL | 1 |
| Bocchetta, M; Carbone, M; Gazdar, AF; Minna, JD; Shivapurkar, N; Toyooka, KO; Toyooka, S | 1 |
| Fukuyama, Y; Gazdar, AF; Minna, JD; Tockman, MS; Toyooka, S; Wistuba, II | 1 |
| Fang, D; Setaluri, V; Tsuji, Y | 1 |
| Bayatti, N; Behl, C; Goodenough, S; Manthey, D; van der Burg, B; Zschocke, J | 1 |
| Bestor, TH; Lynch, CA; Tycko, B; Walsh, CP | 1 |
| Chaudhary, PM; Gazdar, AF; Harada, K; Hay, RJ; Maitra, A; Mastrangelo, D; Matta, H; Miyajima, K; Reddy, JL; Shivapurkar, N; Timmons, CF; Tomlinson, GE; Toyooka, S | 1 |
| Erdlenbruch, B; Kanbach, K; Monkemeyer, S; Pekrun, A; Reinhardt, D; Rönndahl, G; Witt, O | 1 |
| Bai, S; Datta, J; Dong, X; Ghoshal, K; Jacob, ST; Majumder, S; Parthun, M | 1 |
| Chen, LF; Guo, WH; Ito, K; Ito, Y; Nakanishi, H; Tatematsu, M; Weng, LQ | 1 |
| Issa, JP; Kondo, Y; Shen, L | 1 |
| Haleem, K; Sen, N; Siddique, AB; Simmons, WJ; Thomas, RM; Tsiagbe, VK; Zhang, DJ | 1 |
| Hoque, MO; Meltzer, SJ; Mori, M; Osada, M; Sato, F; Sidransky, D; Upadhyay, S; Xiao, Y; Yamashita, K | 1 |
| Baylin, SB; Eguchi, S; Fahrner, JA; Herman, JG | 1 |
| Bernstein, M; Momparler, LF; Momparler, RL; Shaker, S | 1 |
| de la Chapelle, A; Huang, Y; Pellegata, NS | 1 |
| Flaswinkel, H; Hoeflich, A; Shi, W; Stojkovic, M; Wolf, E; Zakhartchenko, V | 1 |
| Enright, BP; Kubota, C; Tian, XC; Yang, X | 1 |
| Bartoli, A; Delfino, DV; Di Ianni, M; Fetriconi, I; Fettucciari, K; Marconi, P; Rosati, E; Rossi, R; Tabilio, A | 1 |
| Maatouk, DM; Resnick, JL | 1 |
| Bhakat, KK; Mitra, S | 1 |
| Andrews, LG; Hansen, NJ; Key, JS; Lopatina, NG; Pita, MA; Poole, JC; Saldanha, SN; Tollefsbol, TO | 1 |
| Bang, YJ; Dimtchev, A; Jeong, SJ; Jong, HS; Jung, M; Kim, NK; Kim, TY; Lee, JW; Song, SH | 1 |
| Borczuk, AC; Brody, JS; Busch, S; Capurro, M; D'Armiento, JM; Filmus, J; Kim, H; Lange, J; Powell, CA; Rothman, PB; Xu, GL | 1 |
| Hirokawa, Y; Matsuzaki, T; Shiraishi, T; Sugimura, Y; Suzuki, H; Takagi, A; Watanabe, M; Yamada, Y; Yamanaka, M; Yatani, R | 1 |
| Bang, YJ; Cho, B; Hwang, KS; Jeong, S; Jeoung, DI; Kang, GH; Kim, HY; Lee, H; Lee, HJ; Lee, YS | 1 |
| D'Ambrosio, E; Di Nardo, P; Grassi, G; Grassi, M; Kaiser, H; Kandolf, R; Kuhn, A; Küpper, JH; Maccaroni, P; Meyer, R; Pascale, E | 1 |
| Ali-Osman, F; Dinh, DH; Foster, DC; Gujrati, M; Kisiel, W; Kondraganti, S; Konduri, SD; Lakka, SS; Olivero, WC; Rao, JS; Srivenugopal, KS; Yanamandra, N | 1 |
| Chen, HB; Costa, M; Kluz, T; Yan, Y; Zhang, P | 1 |
| Iwanari, M; Nakajima, M; Yokoi, T | 1 |
| Fearon, ER; Hinoi, T; Loda, M | 1 |
| Biallek, M; Jonat, W; Klöppel, G; Lüttges, J; Maass, N; Morohoshi, T; Mundhenke, C; Nagasaki, K; Ohike, N; Zhang, M | 1 |
| Hoffman, AR; Hu, JF; Li, T; Ulaner, GA; Vu, TH; Yang, Y | 1 |
| Chan, AS; Chan, TL; Chen, X; Chu, KM; Leung, SY; Li, R; So, S; Tsui, WY; Yuen, ST | 1 |
| Ashhab, Y; Ben-Yehuda, D; Peretz, T; Shteper, PJ; Vlodavsky, I; Zcharia, E | 1 |
| Blazková, J; Elleder, D; Hájková, P; Hejnar, J; Svoboda, J; Walter, J | 1 |
| Correa, P; Ito, Y; Macdonald, J; Peeters, KC; Sasako, M; van de Velde, CJ; Wong, JE | 1 |
| Bone, JR; Briggs, KL; Clayman, GL; Coombes, MM; Dent, SY; El-Naggar, AK | 1 |
| Kim, DH; Kwon, HJ; Shim, JS | 1 |
| Akino, K; Imai, K; Issa, JP; Itoh, F; Kikuchi, T; Mita, H; Murai, M; Obata, T; Ogi, K; Sasaki, Y; Satoh, A; Suzuki, H; Tokino, T; Toyota, M | 1 |
| Hoshikawa, Y; Jonat, W; Jünemann, KP; Maass, N; Minei, S; Nagasaki, K; Sato, K; Sugimoto, S; Takimoto, Y; Zhang, M | 1 |
| Hattori, N; Ko, YG; Nishino, K; Ohgane, J; Shiota, K; Tanaka, S | 1 |
| Blaschke, B; Knobbe, CB; Reifenberger, G; Reifenberger, J; Ruzicka, T; Schulte, KW; Sterzinger, AA | 1 |
| Araki, H; DeSimone, J; Hoffman, R; Lavelle, D; Mahmud, N; Milhem, M; Saunthararajah, Y | 1 |
| Li, HH; Li, M; Lou, FD; Lu, XC; Xu, ZM; Yu, L; Zhao, Y | 1 |
| Aapola, U; Kaipia, A; Mäenpää, K; Peterson, P | 1 |
| Blaschke, B; Knobbe, CB; Reifenberger, G; Reifenberger, J | 1 |
| David, GL; De Marzo, AM; Kumar, A; Lin, X; Marchi, VL; Nelson, WG; Yegnasubramanian, S | 1 |
| Moore, G; Reader, S; Shaw, P; Vorontsova, M | 1 |
| Aventín, A; Brunet, S; Carnicer, MJ; Estivill, C; Lasa, A; Nomdedéu, JF; Sierra, J | 1 |
| Heasley, LE; Winn, RA | 1 |
| Fujimoto, H; Imamura, M; Kato, N; Kondo, T; Matsumura, N; Minami, Y; Oishi, I; Tanaka, Y; Tsukada, J; Yoda, A | 1 |
| Berru, M; Ronai, D; Shulman, MJ | 1 |
| Leung, T; Lim, L; Ng, Y; Tan, I | 1 |
| Chen, YX; Fang, JY; Gu, WQ; Lu, J; Lu, LG; Lu, R; Yang, L; Zhu, HY | 1 |
| Kohno, T; Nishioka, M; Ochiai, K; Okamoto, A; Otsuka, A; Tanaka, T; Yanaihara, N; Yokota, J | 1 |
| Carpentieri, D; Flake, AW; Hayashi, S; Ikegaki, N; Kim, DY; Kung, B; Riceberg, JS; Robinson, ME; Tang, XX; Titus, TB | 1 |
| Butler, JS; Ladd, PD; Skalnik, DG | 1 |
| Bisht, KS; Bradbury, CM; Brandenburg, SA; Chuang, EY; Cook, J; Cui, H; Feinberg, AP; Gius, D; Ho, AS; Hu, Y; Mattson, D; Mitchell, JB; Munson, PJ; Smart, DK; Sun, L; Young, L; Zhao, S | 1 |
| Alikhani-Koopaei, R; Fouladkou, F; Frey, BM; Frey, FJ | 1 |
| Eshleman, JR; Fukushima, N; Goggins, M; Iacobuzio-Donahue, CA; Miyagi, Y; Parker, AR; Sato, N | 1 |
| Brent, TP; Danam, RP; Harris, LC; Howell, SR | 1 |
| Dürr, M; Harder, F; Jauch, A; Kirchhof, N; Müller, AM; Schmittwolf, C; Zenke, M | 1 |
| Davidson, NE; Garrett-Mayer, E; Herman, JG; Keen, JC; Mack, KM; Manning, J; Pettit, C | 1 |
| Gan, Y; Shen, YH; Utama, B; Wang, J; Wang, X; Wang, XL | 1 |
| Ahn, HS; Choi, HS; Kang, HJ; Koh, SH; Park, ES; Shin, HY | 1 |
| Hoon, DS; Huang, S; Kim, J; Koyanagi, K; Mori, T; Takeuchi, H; Umetani, N; Yamano, T | 1 |
| Dote, H; Gazdar, AF; Murakami, M; Naito, M; Ota, T; Shimizu, N; Toyooka, S; Toyota, M; Tsukuda, K; Yano, M | 1 |
| Aoyagi, K; Danjoh, I; Fukaya, M; Nishigaki, M; Sakamoto, H; Sasaki, H; Yanagihara, K; Yoshida, T | 1 |
| Attewell, JR; Dowdy, SC; Eberhardt, NL; Jiang, SW; Jin, F; Podratz, KC; Xiong, Y | 1 |
| Barrett, JC; Kumakura, S; Tsutsui, T; Tsutsui, TW; Yagisawa, J | 1 |
| Higashimoto, K; Joh, K; Kudo, S; Matsukura, S; Matsuo, S; Mukai, T; Nakagawachi, T; Soejima, H; Urano, T; Zhao, W | 1 |
| Furukawa, T; Horii, A; Kanai, N; Sunamura, M; Xu, S | 1 |
| Chen, Y; Cui, J; Dou, LP; Lou, FD; Lü, M; Lu, XC; Xu, ZM; Yang, L; Yu, L | 1 |
| Basma, H; Cheng, PW; Choi, KH; Singh, J | 1 |
| D'Abreo, C; Fish, JE; Lin, S; Marsden, PA; Matouk, CC; Rachlis, A; Tai, SC | 1 |
| Jakobsson, J; Lundberg, C; Rosenqvist, N | 1 |
| Law, RD; Suttle, JC | 1 |
| Choi, EJ; Kim, JS; Kim, YH; Seo, JH; Whang, YM; Yoo, YD | 1 |
| Hidaka, E; Kamijo, T; Koike, K; Kubota, T; Sakashita, K; Sugane, K; Zhao, XY | 1 |
| Abe, T; Fukushima, N; Goggins, M; Matsubayashi, H; Sato, N | 1 |
| Brambilla, E; Drabkin, HA; Franklin, W; Kusy, S; Minna, J; Potiron, V; Roche, J; Zeng, C | 1 |
| Dowdy, SC; Eberhardt, NL; Gonzalez Bosquet, J; Jiang, SW; Podratz, KC; Xiong, Y; Zhao, Y | 1 |
| Decoteau, JF; Dong, WF; Geyer, CR; Hirsch, C; Ichinohasama, R; Sanche, SE; Scott, SA; Sheridan, D | 1 |
| Dufau, ML; Fatima, N; Zhang, Y | 1 |
| Brem, G; Ewerling, S; Hofmann, A; Kabermann, A; Kessler, B; Pfeifer, A; Wolf, E | 1 |
| Fushiki, S; Ito, K; Itoh, K; Nishimura, M; Nishiyama, K; Sakakura, C; Shimada, J; Terauchi, K; Yanada, M; Yaoi, T | 1 |
| Horio, Y; Osada, H; Sugito, N; Takahashi, T; Tatematsu, Y | 1 |
| Frühwald, MC; Grotzer, M; Hagemann, C; Jürgens, H; Mühlisch, J; Osada, N; Rickert, CH; Roggendorf, W; Schwering, A; Sörensen, N; Vince, GH | 1 |
| Chen, D; Christman, JK; Fang, MZ; Jin, Z; Sun, Y; Yang, CS | 1 |
| Bocci, G; Ebos, JM; Emmenegger, U; Francia, G; Green, SK; Kerbel, RS; Man, S; Shaked, Y; Weinerman, A | 1 |
| Mitchell, MD; Sato, TA | 1 |
| Cao, F; Gambhir, SS; Gonzalgo, ML; Krishnan, M; Park, JM; Paulmurugan, R; Tseng, JR; Wang, D; Wu, JC | 1 |
| Ankri, S; Bernes, S; Siman-Tov, R | 1 |
| Andreasen, PA; Gao, S; Krogdahl, A; Skeldal, S; Sørensen, JA | 1 |
| Das, S; Dignam, J; Fackenthal, J; Grushko, TA; Hagos, F; Nanda, R; Olopade, OI; Sveen, L; Tretiakova, M; Wei, M; Xu, J | 1 |
| Hara, E; Hozumi, N; Kihara-Negishi, F; Oikawa, T; Sakurai, T; Suzuki, M; Tenen, DG; Yamada, T | 1 |
| Ajima, R; Fujiwara, T; Kohno, T; Minna, JD; Sasaki, H; Takahashi, K; Tanaka, N; Yokota, J | 1 |
| Bai, T; Tanaka, T; Umesaki, N; Yukawa, K | 1 |
| Argani, P; D'Costa, A; Fackler, MJ; Garrett-Mayer, E; Lo, PK; Mehrotra, J; Sukumar, S | 1 |
| Bell, I; Crawley, S; Deng, G; Gum, J; Kakar, S; Kim, YS; Matsuzaki, K; Mehta, KR; Nguyen, A; Sleisenger, MH; Tanaka, H; Terdiman, JP; Waldman, FM | 1 |
| Araki, H; Beam, CA; Hoffman, R; Mahmud, N; Milhem, M; Nunez, R; Xu, M | 1 |
| Ahlquist, DA; Burgart, LJ; Harrington, JJ; Klatt, KK; Lesche, R; Lewin, J; Lofton-Day, C; Molina, JR; Osborn, NK; Zou, H | 1 |
| Chen, BB; Chen, Q; Chen, YM; Song, YF; Xie, Y; Xu, R; Zhang, XH | 1 |
| Baylin, SB; Eguchi, S; Esteller, M; Fraga, MF; Fuks, F; Griffioen, AW; Hellebrekers, DM; Hoebers, NT; Jair, KW; van Engeland, M; Viré, E | 1 |
| Brena, RM; Hackanson, B; Morrison, C; Otterson, GA; Plass, C; Tada, Y | 1 |
| Bernard, O; Gagnon, JF; Guillemette, C; Têtu, B; Villeneuve, L | 1 |
| Chen, X; Herzel, HP; Jammas, D; Krapfenbauer, U; Kuban, RJ; Lund, P; Mikeska, T; Schäfer, R; Sers, C; Ungethüm, U; Walter, J; Weisshaupt, K | 1 |
| Banwell, CM; Campbell, MJ; Colston, KW; Guy, M; MacCartney, DP; Mansi, J; Miles, AE; O'Neill, LP; Stewart, PM; Turner, BM; Uskokovic, MR | 1 |
| Chang, MS; Jung, EJ; Kim, WH; Lee, BL; Lee, YM | 1 |
| Pantel, K; Schwarzenbach, H; Wischnewski, F | 1 |
| Al-Saleem, T; Cairns, P; Dulaimi, E; Hoffman, AM; Ibanez de Caceres, I; Uzzo, RG | 1 |
| Goto, M; Hamada, T; Higashi, M; Nomoto, M; Tsutsumida, H; Yamada, N; Yonezawa, S | 1 |
| Chen, HJ; Dannenberg, LO; Edenberg, HJ; Tian, H | 1 |
| Brooks, CG; Mager, DL; Rouhi, A; Takei, F | 1 |
| Davidson, NE; Saxena, NK; Sharma, D; Vertino, PM | 1 |
| Pampalakis, G; Sotiropoulou, G | 1 |
| Fan, PS; Kahaleh, B; Wang, Y | 1 |
| Bhalla, KN; Huang, C; Inoue, M; Ito, K; Ito, Y; Ko, TK; Lau, QC; Liu, Q; Loh, M; Putti, TC; Raja, E; Salto-Tellez, M; Sukumar, S; Zhu, T | 1 |
| Fahey, J; Field, L; Foltz, G; Frakes, A; Hood, L; Lee, H; Madan, A; Nelson, T; Ryken, TC; Ryu, GY; Sibenaller, Z; Vibhakar, R; Yoon, JG; Zander, K | 1 |
| Hoon, DS; Kitago, M; Martinez, SR; Mori, T; Morton, DL; Nguyen, SL; O'Day, SJ; Tanemura, A; Tran, AN; Umetani, N; Wang, HJ | 1 |
| Das, PM; Ferdinand, L; Gopisetty, G; Ramachandran, K; Reis, IM; Singal, R; Vanwert, J | 1 |
| Dannenberg, LO; Edenberg, HJ | 1 |
| Blaschke, B; Knobbe, CB; Reifenberger, G; van den Boom, J; Wolter, M | 1 |
| Fields, CR; Kim, JH; Kim, TY; Robertson, KD; Zhong, S | 1 |
| Fike, FM; Kuraishy, AI; Loya, RG; Malone, CS; Mikkili, MR; Teitell, MA; Wall, R | 1 |
| Coffin, J; Dokras, A; Field, L; Frakes, A; Lee, H; Madan, A; Nelson, T; Ryu, GY; Yoon, JG | 1 |
| Claus, R; Duque, JA; Fliegauf, M; Kolanczyk, M; Lübbert, M; Stock, M | 1 |
| Baqir, S; Smith, LC | 1 |
| Albert, SH; Liao, D; Liu, J; Niu, Y; Robertson, KD; Santiago, A; Zhao, LY | 1 |
| Cantor, JP; Collins, JE; Druck, T; Friedberg, JS; Han, SY; Huebner, K; Iliopoulos, D; Lakshman, TV; McCorkell, KA; Rao, AS; Semba, S; Wachsberger, P | 1 |
| Brockington, M; Jungbluth, H; Monk, D; Moore, GE; Muntoni, F; Sewry, CA; Stanier, P; Zhou, H | 1 |
| Fields, CR; Pan, YX; Robertson, KD; Su, N; Zhong, S | 1 |
| Abdelkarim, M; Berg, T; Fliegauf, M; Guo, Y; Lübbert, M | 1 |
| Chim, CS; He, H; Jiang, SH; Kung, HF; Leung, SY; Lin, MC; Sun, YW; Tu, SP; Wang, J; Wong, BC; Yang, Y; Yu, LF; Yuen, ST; Zeng, H; Zou, B | 1 |
| Cai, X; Long, JE | 1 |
| Araki, H; Boccuni, P; Hoffman, R; Mahmud, N; Yoshinaga, K; Zhao, Y | 1 |
| Bandle, R; Clair, T; Koh, E; Roberts, DD; Stracke, ML | 1 |
| Bazhin, AV; Eichmüller, SB; Schadendorf, D; Schnölzer, M; Wiedemann, N | 1 |
| Bártová, E; Kozubek, S; Kozubík, A; Pacherník, J | 1 |
| Akahira, J; Ito, K; Moriya, T; Niikura, H; Okamura, K; Sakuma, M; Sasano, H; Yaegashi, N | 1 |
| Hattori, N; Imao, Y; Nishino, K; Ohgane, J; Shiota, K; Tanaka, S; Yagi, S | 1 |
| Abecassis, M; Hummel, M; Li, Z; Varghese, TK; Yan, S | 1 |
| Kalberer, CP; Langenkamp, U; Rohner, A; Siegler, U; Wodnar-Filipowicz, A | 1 |
| Bruserud, Ø; Ryningen, A; Stapnes, C | 1 |
| Choi, HS; Guo, XH; Hwang, CK; Kim, CS; Law, PY; Loh, HH; Song, KY; Wei, LN | 1 |
| Chan, CY; Cheung, OF; Ching, YP; Lee, JM; Ng, IO; Ng, YL; Tung, EK; Wong, CC; Wong, CM | 1 |
| Aubert, JP; Desseyn, JL; Perrais, M; Pigny, P; Van Seuningen, I; Vincent, A | 1 |
| Hou, J; Li, H; Li, J; Liew, CT; Yin, D; Zhang, C; Zhang, J; Zhang, Q; Zhang, T; Zhou, G | 1 |
| Fuks, F; Griffioen, AW; Hellebrekers, DM; Herman, JG; Langenkamp, E; Melotte, V; Molema, G; Van Criekinge, W; van Engeland, M; Viré, E | 1 |
| Jagodzinski, PP; Piotrowska, H | 2 |
| Iliopoulos, D; Malizos, KN; Tsezou, A | 1 |
| Huang, TH; Liu, JC; Plass, C; Potter, D; Smith, LT; Wang, SH; Wu, J; Wu, YZ | 1 |
| Di, GH; Fan, J; Hou, YF; Lei, W; Li, DQ; Lu, JS; Shao, ZM; Shen, ZZ; Wu, FY; Wu, J; Yin, WJ | 1 |
| Daigle, D; Gradoville, L; Miller, G; Ye, J | 1 |
| Aydin, D; Doğan, AL; Güç, D; Taşbasan, B; Tazebay, UH; Tuncel, M; Uğur, O; Yaman, E | 1 |
| Davie, JR; Diasio, RB; Guarcello, V; Li, L; Soong, R; Wang, K; Zhang, X | 1 |
| Bruno, E; Hoffman, R; Hu, W; Ishii, T; Lindgren, V; Shi, J; Sozer, S; Xu, M; Zhang, W; Zhao, Y | 1 |
| Imreh, S; Klein, G; Popescu, NC; Zhou, X | 1 |
| Chen, I; Durante, W; Jamaluddin, MD; Jan, M; Jiang, X; Liu, X; Schafer, AI; Wang, H; Yang, F; Yang, X | 1 |
| Bieblova, J; Bubenik, J; Hejnar, J; Indrova, M; Jandlova, T; Lubyova, B; Manning, J; Pribylova, H; Reinis, M; Simova, J | 1 |
| Keen, JC; Obajimi, O; Pryzbylkowski, P | 1 |
| Akao, Y; Kinoshita, T; Kitade, Y; Nakagawa, Y; Naoe, T | 1 |
| Luo, J; Qi, J; Tao, WH; Zhu, YQ | 1 |
| Carén, H; Ejeskär, K; Fransson, S; Kogner, P; Martinsson, T | 1 |
| D'Souza, T; Honda, H; Ji, H; Morin, PJ; Pazin, MJ | 1 |
| Delmas, AL; Fields, CR; Jin, B; Liu, X; Peng, J; Qiu, J; Robertson, KD; Soo, HM; Tao, Q; Wu, W; Ying, J | 1 |
| Dai, DQ; Meng, CF; Peng, G; Zhu, XJ | 4 |
| Bishop, MC; Li, G; McArdle, SE; Rees, RC; Seth, R; Walton, TJ | 1 |
| Bilban, M; Drach, J; Heller, G; Holzer, S; Müllauer, L; Schmidt, WM; Ziegler, B; Zielinski, CC; Zöchbauer-Müller, S | 1 |
| Aventín, A; Brunet, S; Carnicer, MJ; Lasa, A; Nomdedéu, JF; Orantes, V; Pena, J; Serrano, E; Sierra, J | 1 |
| Arrouss, I; Billot, K; Cario-Andre, M; Duhamel, M; Navarro, P; Rebollo, A | 1 |
| Cooper, DA; Kelleher, AD; Lim, HG; Suzuki, K | 1 |
| Di, GH; Fan, J; Lu, JS; Shao, ZM; Shen, ZZ; Wang, L; Wu, FY; Wu, J; Yin, WJ | 1 |
| Cirillo, LA; Horswill, MA; Narayan, M; Twining, SS; Warejcka, DJ | 1 |
| Cao, J; Jiang, J; Jiang, Y; Li, G; Li, N; Wang, S; Xiong, J | 1 |
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| Lau, KM; Li, KK; Mao, Y; Ng, HK; Pang, JC; Poon, WS; Wang, Y; Zhou, L | 1 |
| Chan, AK; Lau, KM; Li, KK; Mao, Y; Ng, HK; Pang, JC; Poon, WS; Shi, Z; Wang, Y; Yang, L; Zhou, L | 1 |
| Mikkelsen, JG; Nielsen, AL; Pedersen, FS; Wolf, G | 1 |
| Chen, J; Peng, L; Ren, G; Tan, C; Yang, Z | 1 |
| Brewer, MA; Meng, F; Sun, G; Yu, Y; Zhong, M | 2 |
| Chen, H; Hardy, TM; Li, Y; Meeran, SM; Patel, SN; Tollefsbol, TO | 1 |
| Laska, MJ; Nexø, BA; Nissen, KK | 1 |
| Ambs, S; Calin, GA; Croce, CM; Esposito, D; Hudson, RS; Liu, CG; Prueitt, RL; Schetter, AJ; Stephens, RM; Van Roosbroeck, K; Volfovsky, N; Volinia, S; Yi, M | 1 |
| Agarwal, C; Agarwal, R; Chan, D; Mateen, S; Raina, K | 1 |
| Camacho-Arroyo, I; García-Gómez, E; González-Arenas, A; Hansberg-Pastor, V; Peña-Ortiz, MA; Rodríguez-Dorantes, M | 1 |
| Antonicelli, F; Diederich, M; Doliwa, C; Dufer, J; Poplineau, M; Schnekenburger, M; Trussardi-Régnier, A | 1 |
| Brown, CO; Fitzgerald, MP; Goel, A; Salem, K; Schibler, J; Singh, N; Zhan, F | 1 |
| Held, G; Kaddu-Mulindwa, D; Kubuschok, B; Neumann, F; Pfreundschuh, M; Preuss, KD; Roemer, K; Widmann, T; Zwick, C | 1 |
| Cao, K; Dhara, SK; Fan, Y; Majumder, A; Medrzycki, M; Mithani, M; Stice, SL; Swetenburg, R | 1 |
| Bendinelli, P; Desiderio, MA; Locatelli, A; Maroni, P; Matteucci, E | 1 |
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| Cai, X; Chen, K; Chen, Q; Huang, A; Li, S; Nie, D; Quan, H; Shan, X; Tang, N; Zhou, F; Zhou, Z | 1 |
| Greene, WK; Kees, UR; Welch, MD | 1 |
| Argraves, WS; Aseem, O; Barth, JL; Klatt, SC; Smith, BT | 1 |
| Hinoda, Y; Morishige, A; Nakamura, M; Nishikawa, J; Oga, A; Okada, T; Saito, M; Sakai, K; Sakaida, I; Sasaki, K; Suehiro, Y; Zhang, Y | 1 |
| Guo, LH; He, JS; Li, H; Wang, F; Yu, J | 1 |
| Chen, HB; Jiang, SW; Li, J; Liu, Q; Ren, J; Wang, Y; Xu, S; Zhang, R | 1 |
| Al-Nakhle, H; Bell, SM; Burns, PA; Cummings, M; Hanby, AM; Hughes, TA; Lane, S; Parker, MD; Smith, L; Speirs, V | 1 |
| Gacek, A; Rychli, K; Strauss, J; Sulyok, M; Wagner, M; Zutz, C | 1 |
| Abe, K; Egawa, S; Fukushige, S; Horii, A; Kaneko, N; Karasawa, H; Miura, K; Mizuguchi, Y; Morishita, K; Motoi, F; Nagase, H; Saiki, Y; Sasaki, I; Sase, T; Shibata, C; Sunamura, M; Unno, M; Yamamura, A | 1 |
| Chen, X; Liu, Y; Long, Q; Meng, S; Ren, K; Song, N; Xie, Y; Zhao, X | 1 |
| Clifford, SC; Farwick, N; Frühwald, MC; Gerss, J; Hasselblatt, M; Kerl, K; Kreth, JH; Lechtape, B; Mühlisch, J; Plagemann, T; Richter, GH; Schlosser, S; Unland, R | 1 |
| Green, BB; Kerr, DE | 1 |
| Geng, CZ; Hou, SY; Liu, WH; Lü, WH; Sang, MX; Shan, BE; Xu, YY | 1 |
| Araki, H; Baluchamy, S; Lavelle, D; Li, X; Mahmud, N; Petro, B; Quigley, JG; Suphangul, M; Taioli, S | 1 |
| Dong, L; Lei, H; Li, Z; Liu, C; Luo, M; Ma, Y; Shen, J; Song, W; Wang, F; Wang, Y; Yu, J; Zhang, J | 1 |
| Komandirov, MA; Sharifulina, SA; Uzdensky, AB | 1 |
| Brglez, V; Lambeau, G; Petan, T; Pucer, A; Pungerčar, J | 1 |
| Al-Rayyan, N; Cheng, A; Elbedewy, A; Ivanova, MM; Klinge, CM; Litchfield, LM; Radde, BN | 1 |
| Chen, H; Chu, Y; Dowdy, SC; Jiang, SW; Li, J; Liu, F; Wang, Y; Xiong, Y; Zhang, G; Zhang, R | 1 |
| Ackley, A; Bosque, A; Clemson, M; Famiglietti, M; Morris, KV; Planelles, V; Saayman, S; Turner, AW | 1 |
| Alp, E; Gurocak, S; Konac, E; Menevse, S; Onen, IH; Sozen, S; Varol, N; Yilmaz, A | 1 |
| Huang, S; Luo, M; Ning, Q; Qin, Y; Shao, S; Yuan, N; Zhang, X; Zhao, X; Zuo, X | 1 |
| Bai, W; Gao, A; Niu, P; Tian, L; Yang, J; Zuo, X | 1 |
| Ali, D; Bengtzen, S; Deneberg, S; Kanduri, M; Karimi, M; Kimby, E; Lehmann, S; Lennartsson, A; Mansouri, L; Qu, Y; Rosenquist, R | 1 |
| Chen, LB; Guan, XX; Lu, XX; Tong, JD; Wang, JZ; Wang, Z; Zhang, YW; Zheng, Y | 1 |
| Poplutz, MK; Rink, L; Uciechowski, P; Wessels, I | 1 |
| Cui, ZG; Feng, XQ; Guo, J; Liu, SG; Meng, FJ; Nie, SM; Shi, X; Su, Z; Zhang, L; Zhao, CT | 1 |
| Dong, Z; Guo, W; Guo, Y; Kuang, G; Shen, S; Yang, Z; Zhang, M | 1 |
| Motevalli, A; Roberts, T; Slijepcevic, P; Virmouni, SA; Yasaei, H | 1 |
| Dawn, B; Elias, HK; Malik, AB; Rajasingh, J; Rajasingh, S; Simpson, AD; Sundivakkam, PK; Thangavel, J; Vogel, SM; Xuan, YT | 1 |
| Fu, B; Li, ZQ; Liu, D; Ma, H; Qi, MY; Wang, L; Wang, WT; Zhang, X; Zhang, YL | 1 |
| Bivalacqua, T; Brait, M; Driscoll, T; Hoque, MO; Maldonado, L; Michailidi, C; Munari, E; Netto, GJ; Schoenberg, M; Schultz, L; Sidransky, D | 1 |
| He, HB; Huan, YJ; Kong, QR; Li, JY; Liu, ZH; Wang, HM; Wu, ZF; Xie, BT; Zhang, JG; Zhu, J | 1 |
| Deng, Y; Guo, X; Li, T; Liu, L; Lu, X; Yu, G; Zhang, Y | 1 |
| Chen, G; Fan, Y; Jin, J; Li, L; Liu, Q; Tao, Q; Wang, L; Wang, Z; Xu, B; Ying, J; Zhang, L; Zhang, Q | 1 |
| Domann, FE; Hudachek, DR; Vorrink, SU | 1 |
| Boucher, J; Charalambous, M; Ferguson-Smith, AC; Kahn, CR; Kleinridders, A; Mori, MA; Ristow, M; Zarse, K | 1 |
| Lin, S; Luo, Y; Tang, S; Tian, J; Wei, L; Xie, M | 1 |
| Araki, H; Koca, E; Mahmud, N; Park, Y; Petro, B; Rondelli, D; Saraf, S; Taioli, S; Yoshinaga, KG | 1 |
| Arizumi, T; Chishina, H; Hagiwara, S; Inoue, T; Kitai, S; Kudo, M; Minami, Y; Nishida, N; Sakurai, T; Takita, M; Ueshima, K; Yada, N | 1 |
| Agrawal, H; Chauhan, MS; Manik, RS; Palta, P; Saini, M; Selokar, NL; Singla, SK | 2 |
| Chiyomaru, T; Enokida, H; Goto, Y; Higashimoto, I; Inoue, H; Mataki, H; Matsushita, R; Mizuno, K; Nakagawa, M; Nishikawa, R; Samukawa, T; Seki, N | 1 |
| Carreon, S; Denny, AD; Li, JG; Lieu, M; Qiang, M; Yao, JM; Zhang, K | 1 |
| Dong, Z; Guo, W; Guo, X; Guo, Y; Kuang, G; Shen, S; Wang, C | 1 |
| Dehghani, M; Kianpour, S; Mokarram, P; Monabati, A; Mostafavi-Pour, Z; Torabinejad, S | 1 |
| Falahi, F; Huisman, C; Karsten, G; Kok, K; Overkamp, J; Rots, MG; Schuuring, E; Terpstra, MM; van der Wijst, MG; van der Zee, AG; Wisman, GB | 1 |
| Acun, T; Arango, D; Demir, K; Oztas, E; Yakicier, MC | 1 |
| Apprey, V; Devaney, JM; Furbert-Harris, P; Ittmann, M; Kwabi-Addo, B; Lee, NH; Olender, J; Wang, BD; Wang, S | 1 |
| Abdel-Wahab, AH; Al Homssi, A; Al-Tel, T; Al-Tunaiji, H; El-Awady, RA; El-Serafi, A; Hersi, F; Saleh, EM; Suhail, M | 1 |
| Hoffman, R; Iancu-Rubin, C | 1 |
| He, H; Huan, Y; Liu, Z; Wang, H; Wu, Z; Zhang, J; Zhu, J | 1 |
| Huan, Y; Liu, Z; Song, X; Wu, Z; Zhang, J; Zhu, J | 1 |
| Barani, B; Dawn, B; Rajasingh, J; Rajasingh, S; Samanta, S; Thangavel, J; Xuan, YT | 1 |
| Bapat, SA; Chandra, N; Singh, AK | 1 |
| Ackley, A; Burdach, J; Clemson, M; Hart, J; Lenox, A; Morris, KV; Saayman, S; Vadie, N; Vogt, PK | 1 |
| Behboudi, A; Dios, DG; Hedberg Oldfors, C; Karlsson, S; Linder, A; Nilsson, S; Samuelson, E; Visuttijai, K | 1 |
| Goes, FS; Ishizuka, K; Kano, S; Koga, M; Kondo, MA; Obie, C; Passeri, E; Primerano, A; Rapoport, JL; Sawa, A; Sengupta, S; Srivastava, R; Valle, D; Wilson, AM; Zandi, PP | 1 |
| Berdasco, M; Blanco-Luquin, I; Coca, V; Cordoba, A; De La Cruz, S; Escors, D; Guerrero-Setas, D; Ibañez, B; Illarramendi, JJ; Jauregui, I; Kochan, G; Lera, JM; Liechtenstein, T; Perez-Janices, N; Torrea, N; Vicente-Garcia, F | 1 |
| Bae, YJ; Kim, HJ; Kim, YJ; Kwon, YR | 1 |
| Chen, CT; Lee, MJ; Li, PT; Tsai, YJ | 1 |
| Ito, S; Uchida, H | 1 |
| Deng, Y; Liu, D; Sheng, Y; Wang, H; Yang, F; Zhang, C; Zhang, T | 1 |
| Ema, A; Enomoto, T; Katoh, H; Kikuchi, M; Kojo, K; Kosaka, Y; Minatani, N; Sawanobori, M; Sengoku, N; Tanino, H; Ushiku, H; Waraya, M; Watanabe, M; Yamashita, K | 1 |
| Li, B; Li, D; Lian, C; Tang, B; Wang, K; Wang, M; Wang, X; Wang, Y; Xiao, T; Zhang, W; Zhang, Y; Zuo, Q | 1 |
| Drzewiecka, H; Dyszkiewicz, W; Gałęcki, B; Jagodziński, PP; Jarmołowska-Jurczyszyn, D; Kluk, A | 1 |
| Dang, Q; Dong, B; Guo, Y; Jin, X; Li, Y; Lin, D; Liu, Y; Lu, Y; Quan, C; Ruan, Y; Song, P; Xie, Y; Yang, M; Zhao, S | 1 |
| Clarke, PAG; Davis, R; Kwabi-Addo, B; Mumuni, S; Wang, S | 1 |
| Cheng, L; Hou, Y; Luo, T; Wang, F; Wang, H; Xu, J | 1 |
| Arnold, RD; Cummings, BS; Glenn, TC; Kolli, RT; Moore, M; Scholpa, NE | 1 |
| Cang, M; Gao, XY; He, N; Liang, H; Liu, DJ; Nuo, MT; Yang, WL; Yuan, JL | 1 |
| Bisogno, G; Celegato, B; Lanfranchi, G; Martini, P; Millino, C; Pacchioni, B; Poli, E; Romualdi, C; Rosolen, A; Tombolan, L; Zin, A | 1 |
| Camões, SP; Castro, M; Cipriano, M; Correia, JC; Cruz, H; Cruz, P; Miranda, JP; Oliveira, NG; Ruas, JL; Santos, JM | 1 |
| Ali, MW; Alqinyah, M; Cacan, E; Gao, M; Greer, SF; Hooks, SB; Maganti, N; Weng, HR; Yadav, R | 1 |
| Akizuki, R; Endo, S; Hichino, A; Ikari, A; Matsunaga, T; Okamoto, M; Taga, S | 1 |
| Chang, YW; Singh, KP | 1 |
| Acun, T; Doberstein, N; Gemoll, T; Habermann, JK; Oztas, E; Ried, T; Thorns, C | 1 |
| Darwish, HA; Diab, I; Helmy, MW; Motawi, TK; Noureldin, MH | 1 |
| Blennerhassett, MG; Bonafiglia, QA; Hurlbut, DJ; Lourenssen, SR | 1 |
| Baharvand, H; Javan, M; Zare, L | 1 |
| Cui, NX; Li, L; Li, Y; Rong, L; Yang, SQ; Yi, ZC; Yu, CH; Zhao, X | 1 |
| Sangeeta, K; Yenugu, S | 1 |
| Li, X; Yu, Q | 1 |
| Fu, B; Li, Q; Liu, P; Tao, F; Wu, S; Zhang, P | 1 |
| Feng, X; Huang, J; Meng, F; Nie, S; Wang, W; Yan, X; Zhang, L; Zhuang, L | 1 |
| Alisch, R; Bauer, A; Borth, L; Cook, T; Gorges, LR; Hariharan, N; Hogan, KJ; Iskandar, BJ; Keles, S; Kuehn, T; Lake, W; Madrid, A; Newton, MA; Ondoma, S; Papale, LA; Patel, NJ; Rizk, E; Stewart, K; Vadakkadath Meethal, S; Weber, K | 1 |
| Atri, S; Hodjat, M; Nasoohi, N | 1 |
| Hartung, EE; Mukhtar, SZ; Niles, LP; Shah, SM | 1 |
| Chen, J; Chen, X; Huang, D; Li, H; Ling, X; Liu, L; Pan, Z; Tan, Q; Zhang, H; Zheng, D; Zhong, B | 1 |
| Amirinia, F; Asadi, N; Hodjat, M; Jourshari, PB | 1 |
| Mrozowicz, J; Samiec, M; Sawicki, S; Szmatoła, T; Witarski, W; Ząbek, T | 1 |
2 review(s) available for azacitidine and trichostatin a
| Article | Year |
|---|---|
HIV latency reversal agents: A potential path for functional cure?
Topics: Anti-HIV Agents; CD4-Positive T-Lymphocytes; Histone Deacetylase Inhibitors; HIV Infections; HIV-1; Humans; Molecular Structure; Virus Latency | 2021 |
Role of epigenetic reprogramming in hematopoietic stem cell function.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Proliferation; Cellular Reprogramming; Chromatin; Cytokines; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Lithium Chloride; Valproic Acid | 2015 |
2 trial(s) available for azacitidine and trichostatin a
| Article | Year |
|---|---|
Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential.
Topics: Animals; Antigens, CD34; Azacitidine; Cell Division; Cells, Cultured; Chromatin; Cytokines; Decitabine; Enzyme Inhibitors; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Thy-1 Antigens; Time Factors; Transplantation, Heterologous; Up-Regulation | 2007 |
Treatment of nuclear-donor cells or cloned zygotes with chromatin-modifying agents increases histone acetylation but does not improve full-term development of cloned cattle.
Topics: Acetylation; Animals; Azacitidine; Cattle; Cell Nucleus; Cells, Cultured; Chromatin Assembly and Disassembly; Cloning, Organism; Decitabine; Embryonic Development; Female; Histone Deacetylase Inhibitors; Histones; Hydralazine; Hydroxamic Acids; Nuclear Transfer Techniques; Pregnancy; Term Birth; Up-Regulation; Valproic Acid; Zygote | 2012 |
504 other study(ies) available for azacitidine and trichostatin a
| Article | Year |
|---|---|
Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase.
Topics: Animals; Azacitidine; beta-Galactosidase; Butyrates; Butyric Acid; Cloning, Molecular; Cytomegalovirus; Dependovirus; Enzyme Inhibitors; Gene Expression; Genes, Reporter; Genetic Therapy; Genetic Vectors; Globins; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Polymerase Chain Reaction; Recombinant Proteins; Retroviridae; Transfection; Tumor Cells, Cultured | 1997 |
Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance.
Topics: Azacitidine; Brassica; Butyrates; Butyric Acid; Cell Nucleolus; Cytosine; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Plant; Genes, Dominant; Histones; Hydroxamic Acids; Polyploidy; RNA Polymerase I; RNA, Ribosomal; Transcription, Genetic | 1997 |
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Cell Cycle Proteins; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MutL Protein Homolog 1; Neoplasm Proteins; Neoplasms; Nuclear Proteins; Promoter Regions, Genetic; Tissue Inhibitor of Metalloproteinase-3; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Proteins | 1999 |
Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.
Topics: Acetylation; Acetyltransferases; Azacitidine; Cells, Cultured; Chromatin; Decitabine; DNA; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Histone Acetyltransferases; Histones; Humans; Hydroxamic Acids; Male; Nerve Tissue Proteins; Protein Binding; RNA-Binding Proteins; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 1999 |
Epigenetic regulation of gelsolin expression in human breast cancer cells.
Topics: Acetylation; Apoptosis; Azacitidine; Blotting, Southern; Breast; Cell Cycle; Cells, Cultured; CpG Islands; DNA Methylation; DNA Mutational Analysis; Enzyme Inhibitors; Epithelial Cells; Female; Gelsolin; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Introns; Neoplasm Proteins; Protein Processing, Post-Translational; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm | 1999 |
Quantitative PCR analysis of HbF inducers in primary human adult erythroid cells.
Topics: Adult; Azacitidine; Butyric Acid; DNA, Complementary; Erythroid Precursor Cells; Erythropoietin; Fetal Hemoglobin; Gene Expression Regulation; Globins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Hydroxyurea; Polymerase Chain Reaction; RNA, Messenger | 2000 |
Mechanism for inactivation of the KIP family cyclin-dependent kinase inhibitor genes in gastric cancer cells.
Topics: Azacitidine; Butyric Acid; CDC2 Protein Kinase; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor p57; Decitabine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microtubule-Associated Proteins; Nuclear Proteins; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2000 |
Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast; Breast Neoplasms; Cell Line; Chromatin; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Epithelial Cells; Female; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Receptors, Estrogen; Receptors, Retinoic Acid; Tretinoin; Tumor Cells, Cultured | 2000 |
The mouse tumor cell lines EL4 and RMA display mosaic expression of NK-related and certain other surface molecules and appear to have a common origin.
Topics: Acetylation; Animals; Antigens, Ly; Antigens, Surface; Azacitidine; CD2 Antigens; CD3 Complex; CD4 Antigens; Cell Lineage; Clone Cells; DNA Methylation; Gene Expression Regulation, Neoplastic; Genetic Variation; Histones; Hyaluronan Receptors; Hydroxamic Acids; Killer Cells, Natural; Lectins, C-Type; Membrane Glycoproteins; Mice; Mosaicism; NK Cell Lectin-Like Receptor Subfamily B; Receptors, Immunologic; Receptors, NK Cell Lectin-Like; RNA, Messenger; Tumor Cells, Cultured | 2000 |
Long-term silencing of retroviral vectors is resistant to reversal by trichostatin A and 5-azacytidine.
Topics: Acetylation; Acetyltransferases; Azacitidine; beta-Galactosidase; Cell Line; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Gene Silencing; Genetic Therapy; Genetic Vectors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Retroviridae; Treatment Failure | 2000 |
Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites.
Topics: Alleles; Animals; Azacitidine; Base Sequence; Cell Line; Cloning, Molecular; CpG Islands; Cricetinae; Decitabine; DNA Methylation; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hybrid Cells; Hydroxamic Acids; Hypoxanthine Phosphoribosyltransferase; Molecular Sequence Data; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; X Chromosome | 2001 |
Position effects are influenced by the orientation of a transgene with respect to flanking chromatin.
Topics: Animals; Azacitidine; Chromatin; Deoxyribonuclease I; DNA Methylation; Enhancer Elements, Genetic; Flow Cytometry; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Genomic Imprinting; Globins; Hydroxamic Acids; In Situ Hybridization, Fluorescence; Integrases; Locus Control Region; Mice; Mutagenesis, Insertional; Promoter Regions, Genetic; Transcriptional Activation; Transfection; Transgenes; Tumor Cells, Cultured; Viral Proteins | 2001 |
Epigenetic regulation of androgen receptor gene expression in human prostate cancers.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Binding Sites; Cyclic AMP Response Element-Binding Protein; Decitabine; Dinucleoside Phosphates; DNA Methylation; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostatic Neoplasms; Receptors, Androgen; Tumor Cells, Cultured | 2000 |
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
Topics: Acetylation; Apoptosis; Azacitidine; Decitabine; DNA Modification Methylases; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Oligopeptides; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells.
Topics: 5' Untranslated Regions; Antimetabolites, Antineoplastic; Azacitidine; Biological Transport; Carrier Proteins; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Reporter; Histones; Humans; Hydroxamic Acids; In Situ Hybridization, Fluorescence; K562 Cells; Karyotyping; Leukemia, Erythroblastic, Acute; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Promoter Regions, Genetic; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Translocation, Genetic | 2001 |
Selective association of the methyl-CpG binding protein MBD2 with the silent p14/p16 locus in human neoplasia.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Chromatin; Colonic Neoplasms; CpG Islands; Cross-Linking Reagents; DNA; DNA Methylation; DNA-Binding Proteins; Formaldehyde; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, p16; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Models, Genetic; Promoter Regions, Genetic; Protein Binding; Proteins; RNA, Messenger; Substrate Specificity; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p14ARF | 2001 |
Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes.
Topics: Acetylation; Animals; Animals, Newborn; Azacitidine; Cells, Cultured; DNA Methylation; DNA-Binding Proteins; Embryonic and Fetal Development; Gene Expression Regulation, Enzymologic; Gene Silencing; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Hepatocytes; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Liver; Mice; Nuclear Proteins; Phenylalanine Hydroxylase; Transcription Factors; Transcriptional Activation | 2001 |
Evidence for gene silencing in Haemophilus influenzae.
Topics: Azacitidine; Butyrates; Chloramphenicol; DNA-Directed RNA Polymerases; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Frequency; Gene Silencing; Haemophilus influenzae; Hydroxamic Acids; Microbial Sensitivity Tests; Mutation; Plasmids; Rifampin; Transformation, Bacterial | 2001 |
Cytosine methylation represses glutathione S-transferase P1 (GSTP1) gene expression in human prostate cancer cells.
Topics: Azacitidine; Base Sequence; Cytosine; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Glutathione Transferase; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoenzymes; Male; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; Prostatic Neoplasms; Transfection; Tumor Cells, Cultured | 2001 |
Nitric oxide (NO), methylation and TIMP-1 expression in BL6 melanoma cells transfected with MHC class I genes.
Topics: Antimetabolites, Antineoplastic; Azacitidine; CpG Islands; DNA Methylation; Enzyme Inhibitors; Genes, MHC Class I; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melanoma; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tumor Cells, Cultured; Up-Regulation | 2000 |
DNA methylation regulates placental lactogen I gene expression.
Topics: Animals; Azacitidine; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation; Hydroxamic Acids; Placental Lactogen; Promoter Regions, Genetic; Rats; Rats, Inbred BUF; RNA, Messenger; Tissue Distribution; Transcriptional Activation | 2001 |
Antineoplastic action of 5-aza-2'-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Decitabine; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Receptors, Estrogen; Receptors, Retinoic Acid; Tumor Cells, Cultured | 2001 |
Epigenetic regulation of the KAI1 metastasis suppressor gene in human prostate cancer cell lines.
Topics: Adenocarcinoma; Antigens, CD; Azacitidine; Base Sequence; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Kangai-1 Protein; Male; Membrane Glycoproteins; Molecular Sequence Data; Neoplasm Metastasis; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Proto-Oncogene Proteins; Sulfites; Tumor Cells, Cultured | 2001 |
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Topics: Acetylation; Azacitidine; Breast Neoplasms; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Synergism; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Fulvestrant; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Receptors, Estrogen; RNA, Messenger; Tumor Cells, Cultured | 2001 |
Methylation-mediated silencing of TMS1/ASC is accompanied by histone hypoacetylation and CpG island-localized changes in chromatin architecture.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Binding Sites; CARD Signaling Adaptor Proteins; Cells, Cultured; Chromatin; CpG Islands; Cytoskeletal Proteins; Decitabine; Deoxyribonuclease I; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Fibroblasts; Gene Silencing; Histones; Humans; Hydroxamic Acids; Models, Genetic; Polymerase Chain Reaction; Precipitin Tests; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2002 |
Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cyclooxygenase 2; Cytosine; Decitabine; DNA; DNA Methylation; Enzyme Inhibitors; Gastric Mucosa; Gene Silencing; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Isoenzymes; Membrane Proteins; Methylation; Polymorphism, Single-Stranded Conformational; Precipitin Tests; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Primary acute myeloid leukaemia blasts resistant to cytokine-induced differentiation to dendritic-like leukaemia cells can be forced to differentiate by the addition of bryostatin-1.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Azacitidine; Bryostatins; CD40 Ligand; Cell Differentiation; Child; Cytokines; Dendritic Cells; Drug Resistance; Drug Synergism; Female; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-D Antigens; Humans; Hydroxamic Acids; Immunophenotyping; In Situ Hybridization, Fluorescence; Interleukin-12; Interleukin-4; Karyotyping; Lactones; Leukemia, Myeloid; Lymphocyte Culture Test, Mixed; Macrolides; Male; Middle Aged; Neoplasm Proteins; Neoplastic Stem Cells; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
DNA methylation dominates transcriptional silencing of Pax5 in terminally differentiated B cell lines.
Topics: Animals; Azacitidine; B-Lymphocytes; Decitabine; DNA Methylation; DNA-Binding Proteins; Gene Expression Regulation; Gene Silencing; Hydroxamic Acids; Mice; PAX5 Transcription Factor; Promoter Regions, Genetic; Transcription Factors | 2002 |
Tropomyosin-1, a novel suppressor of cellular transformation is downregulated by promoter methylation in cancer cells.
Topics: Antibiotics, Antineoplastic; Azacitidine; Breast Neoplasms; Chromatin; Decitabine; DNA Methylation; Down-Regulation; Drosophila Proteins; Enzyme Inhibitors; Fibroblasts; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Microscopy, Fluorescence; Promoter Regions, Genetic; Tropomyosin; Tumor Cells, Cultured | 2002 |
Progressive aberrant methylation of the RASSF1A gene in simian virus 40 infected human mesothelial cells.
Topics: Alleles; Azacitidine; Cell Line, Transformed; Cell Transformation, Viral; Cocarcinogenesis; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Expression Regulation; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Mesothelioma; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Simian virus 40; Tumor Suppressor Proteins | 2002 |
Differential expression of FEZ1/LZTS1 gene in lung cancers and their cell cultures.
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Azacitidine; Blotting, Western; Carcinoma, Large Cell; Carcinoma, Squamous Cell; Chromosomes, Human, Pair 8; CpG Islands; Decitabine; DNA Modification Methylases; DNA-Binding Proteins; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Loss of Heterozygosity; Lung Neoplasms; Nerve Tissue Proteins; Polymorphism, Single-Stranded Conformational; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Selective down-regulation of tyrosinase family gene TYRP1 by inhibition of the activity of melanocyte transcription factor, MITF.
Topics: Acetamides; Azacitidine; Binding Sites; Blotting, Northern; Cells, Cultured; Cycloheximide; Decitabine; DNA-Binding Proteins; Down-Regulation; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Humans; Hydroxamic Acids; Luciferases; Melanocytes; Membrane Glycoproteins; Microphthalmia-Associated Transcription Factor; Monophenol Monooxygenase; Mutation; Oxidoreductases; Promoter Regions, Genetic; Protein Binding; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Sequence Deletion; Transcription Factors; Tumor Cells, Cultured | 2002 |
Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells.
Topics: Animals; Azacitidine; Brain; Butadienes; Caveolin 1; Caveolins; Cell Line; Decitabine; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Humans; Hydroxamic Acids; Methylation; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neurons; Nitriles; Promoter Regions, Genetic; Receptors, Estrogen; RNA, Messenger; Transcription, Genetic | 2002 |
Reactivation of a silenced H19 gene in human rhabdomyosarcoma by demethylation of DNA but not by histone hyperacetylation.
Topics: Acetylation; Animals; Azacitidine; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cells, Cultured; DNA Methylation; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Insulin-Like Growth Factor II; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnancy; Rhabdomyosarcoma; RNA; RNA, Long Noncoding; RNA, Untranslated; Tissue Plasminogen Activator | 2002 |
Deregulation of caspase 8 and 10 expression in pediatric tumors and cell lines.
Topics: Azacitidine; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 10; Caspase 8; Caspase 9; Caspases; Child; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Amplification; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, myc; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Neoplasm Proteins; Neoplasms; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
Topics: Amides; Azacitidine; Benzamides; Butyrates; Enzyme Inhibitors; Fetal Hemoglobin; Gene Expression Regulation; Gene Expression Regulation, Leukemic; Globins; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Hydroxyurea; Imidazoles; K562 Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Phenylbutyrates; Pyridines; Vorinostat | 2003 |
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure.
Topics: Acetylation; Animals; Azacitidine; Base Sequence; Chromatin; Chromosomal Proteins, Non-Histone; DNA (Cytosine-5-)-Methyltransferases; DNA Footprinting; DNA-Binding Proteins; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Metallothionein; Methyl-CpG-Binding Protein 2; Mice; Models, Genetic; Molecular Sequence Data; Promoter Regions, Genetic; Repressor Proteins; Sequence Analysis, DNA; Transcription Factor MTF-1; Transcription Factors; Tumor Cells, Cultured; Zinc | 2002 |
Inhibition of growth of mouse gastric cancer cells by Runx3, a novel tumor suppressor.
Topics: Animals; Azacitidine; Base Sequence; Cell Division; Core Binding Factor Alpha 3 Subunit; CpG Islands; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Gene Silencing; Genes, Tumor Suppressor; Hydroxamic Acids; Mice; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms; Transcription Factors | 2002 |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Tumor Cells, Cultured | 2003 |
Regulation of mouse mammary tumor virus env transcriptional activator initiated mammary tumor virus superantigen transcripts in lymphomas of SJL/J mice: role of Ikaros, demethylation, and chromatin structural change in the transcriptional activation of ma
Topics: Animals; Azacitidine; Chromatin; Deoxyribonuclease I; DNA Methylation; DNA-Binding Proteins; Female; Genes, env; Hydroxamic Acids; Ikaros Transcription Factor; Lymphoma, B-Cell; Mammary Tumor Virus, Mouse; Mice; Promoter Regions, Genetic; Retroviridae Infections; RNA, Messenger; Superantigens; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Tumor Virus Infections | 2003 |
Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.
Topics: Azacitidine; Base Sequence; Carcinoma, Squamous Cell; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2002 |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Preclinical evaluation of antineoplastic activity of inhibitors of DNA methylation (5-aza-2'-deoxycytidine) and histone deacetylation (trichostatin A, depsipeptide) in combination against myeloid leukemic cells.
Topics: Acetylation; Acute Disease; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Azacitidine; Cell Division; Decitabine; Depsipeptides; DNA Methylation; DNA Replication; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Hydroxamic Acids; Leukemia, Myeloid; Neoplasm Proteins; Peptides, Cyclic; Protein Processing, Post-Translational; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2003 |
Hypermethylation, but not LOH, is associated with the low expression of MT1G and CRABP1 in papillary thyroid carcinoma.
Topics: Adenocarcinoma, Papillary; Adult; Aged; Azacitidine; Base Sequence; CpG Islands; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Loss of Heterozygosity; Male; Metallothionein; Microsatellite Repeats; Middle Aged; Molecular Sequence Data; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors, Retinoic Acid; Thyroid Neoplasms; Tumor Cells, Cultured | 2003 |
Induction of a senescent-like phenotype does not confer the ability of bovine immortal cells to support the development of nuclear transfer embryos.
Topics: Animals; Apoptosis; Azacitidine; Bromodeoxyuridine; Butyrates; Cattle; Cell Differentiation; Cell Division; Cell Line; Cellular Senescence; Decitabine; DNA Methylation; Embryonic and Fetal Development; Enzyme Inhibitors; Epithelial Cells; Female; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Mammary Glands, Animal; Nuclear Transfer Techniques; Oocytes; Phenotype; Ploidies | 2003 |
Epigenetic characteristics and development of embryos cloned from donor cells treated by trichostatin A or 5-aza-2'-deoxycytidine.
Topics: Acetylation; Animals; Azacitidine; Blastocyst; Cattle; Cloning, Organism; Decitabine; DNA Methylation; DNA Modification Methylases; Embryonic and Fetal Development; Enzyme Inhibitors; Epigenesis, Genetic; Female; Fibroblasts; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Nuclear Transfer Techniques | 2003 |
Effect of trichostatin a and 5'-azacytidine on transgene reactivation in U937 transduced cells.
Topics: Animals; Azacitidine; beta-Galactosidase; Cell Differentiation; Clone Cells; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Genetic Therapy; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Vitro Techniques; Mice; Rats; Simplexvirus; Thymidine Kinase; Transcriptional Activation; Transduction, Genetic; Transgenes; U937 Cells | 2003 |
Continuing primordial germ cell differentiation in the mouse embryo is a cell-intrinsic program sensitive to DNA methylation.
Topics: Alkaline Phosphatase; Animals; Antigens, Nuclear; Azacitidine; Biomarkers; Cell Differentiation; Cell Division; Cells, Cultured; DNA Methylation; Female; Germ Cells; Hydroxamic Acids; Male; Meiosis; Mice; Mice, Inbred Strains; Nuclear Proteins; Oogonia; Sex Differentiation; Spermatogonia; Tetradecanoylphorbol Acetate; Tretinoin | 2003 |
CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration.
Topics: Acetylation; Azacitidine; Cells, Cultured; Chromatin; CpG Islands; Cytosine; DNA Methylation; DNA Primers; Enzyme Inhibitors; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Gene Silencing; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Luciferases; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Restriction Mapping; Transcription, Genetic | 2003 |
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells.
Topics: Antineoplastic Agents; Azacitidine; Catalytic Domain; Cell Differentiation; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Methylation; Promoter Regions, Genetic; Telomerase; Teratocarcinoma; Tretinoin; Tumor Cells, Cultured | 2003 |
Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells.
Topics: Acetylation; Acetyltransferases; Alleles; Azacitidine; Blotting, Northern; Blotting, Southern; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; GTPase-Activating Proteins; Histone Acetyltransferases; Histones; Humans; Hydroxamic Acids; Neoplasm Proteins; Protein Processing, Post-Translational; RNA, Messenger; RNA, Neoplasm; Saccharomyces cerevisiae Proteins; Stomach Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
The heparan sulfate proteoglycan GPC3 is a potential lung tumor suppressor.
Topics: Adenocarcinoma; Animals; Apoptosis; Azacitidine; Cell Line, Tumor; Decitabine; Enzyme Inhibitors; Gene Expression Profiling; Genes, Tumor Suppressor; Glypicans; Humans; Hydroxamic Acids; Lung Neoplasms; Membrane Proteins; Mice; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Respiratory Mucosa; Smoking; Tumor Suppressor Proteins | 2003 |
Aberrant methylation of the vascular endothelial growth factor receptor-1 gene in prostate cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Sulfites; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-1 | 2003 |
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.
Topics: Antigens, Nuclear; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Biomarkers, Tumor; CpG Islands; DEAD-box RNA Helicases; Decitabine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Methylation; Molecular Sequence Data; Neoplasm Staging; Nuclear Proteins; Oligonucleotide Probes; Precancerous Conditions; Promoter Regions, Genetic; Stomach Neoplasms; Transcription Factors; Tumor Cells, Cultured | 2003 |
Inhibitors of DNA methylation and histone deacetylation activate cytomegalovirus promoter-controlled reporter gene expression in human glioblastoma cell line U87.
Topics: Animals; Azacitidine; Cytomegalovirus; DNA Methylation; DNA Replication; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Models, Theoretical; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
Topics: Azacitidine; Brain Neoplasms; Chromatin; Chromosomal Proteins, Non-Histone; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme Inhibitors; Gene Silencing; Glioblastoma; Glioma; Glycoproteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Methyl-CpG-Binding Protein 2; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins | 2003 |
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure.
Topics: Acetylation; Animals; Azacitidine; Bacterial Proteins; Carcinogens; Chromatin; Clone Cells; Cricetinae; Cricetulus; DNA Methylation; Drug Combinations; Escherichia coli Proteins; Gene Expression; Gene Silencing; Histones; Hydroxamic Acids; Lysine; Nickel; Pentosyltransferases; Precipitin Tests; Proteins; RNA, Messenger; Transgenes | 2003 |
Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells.
Topics: 5' Flanking Region; Aryl Hydrocarbon Hydroxylases; Azacitidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Dealkylation; DNA; Environmental Pollutants; Gene Expression Regulation, Enzymologic; HeLa Cells; Histones; Humans; Hydroxamic Acids; Methylation; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfites; Tumor Cells, Cultured | 2003 |
Silencing of CDX2 expression in colon cancer via a dominant repression pathway.
Topics: Adenoma; Azacitidine; Blotting, Western; CDX2 Transcription Factor; Cell Division; Colonic Neoplasms; Cytoplasm; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Immunohistochemistry; Methyltransferases; Mutation; Mutation, Missense; Phenotype; Phosphatidylinositol 3-Kinases; Rectal Neoplasms; Trans-Activators; Transcription, Genetic | 2003 |
Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas.
Topics: Acetylation; Aged; Azacitidine; Carcinoma, Pancreatic Ductal; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Pancreatic Neoplasms; Promoter Regions, Genetic; Proteins; Serpins; Tumor Cells, Cultured; Up-Regulation | 2003 |
The histone code regulating expression of the imprinted mouse Igf2r gene.
Topics: Acetylation; Alleles; Animals; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation; Gene Silencing; Genomic Imprinting; Histones; Hydroxamic Acids; Male; Mice; Pregnancy; Receptor, IGF Type 2 | 2003 |
Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.
Topics: Adenocarcinoma; Azacitidine; Cell Line; Decitabine; DNA Methylation; DNA Modification Methylases; DNA-Binding Proteins; Down-Regulation; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Helix-Loop-Helix Motifs; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Inhibitor of Differentiation Proteins; Microsatellite Repeats; Promoter Regions, Genetic; Stomach Neoplasms; Transcription Factors | 2003 |
Role of promoter methylation in regulation of the mammalian heparanase gene.
Topics: Animals; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Glucuronidase; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Rats | 2003 |
Demethylation of host-cell DNA at the site of avian retrovirus integration.
Topics: Agar; Animals; Azacitidine; Cell Line; Cell Line, Tumor; CpG Islands; Cricetinae; Decitabine; DNA Methylation; Enzyme Inhibitors; Genes, src; Histone Deacetylases; Hydroxamic Acids; Mesocricetus; Models, Genetic; Molecular Sequence Data; Protein Synthesis Inhibitors; Retroviridae; Sulfites; Terminal Repeat Sequences; Transcription, Genetic; Virus Integration | 2003 |
Therapeutic strategies in gastric cancer.
Topics: Animals; Azacitidine; Core Binding Factor Alpha 3 Subunit; DNA-Binding Proteins; Enzyme Inhibitors; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methyltransferases; Mice; Mice, Nude; Stomach Neoplasms; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Squamous Cell; Decitabine; DNA Methylation; Gene Silencing; Genes, p16; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids | 2003 |
Plakoglobin is a new target gene of histone deacetylase in human fibrosarcoma HT1080 cells.
Topics: Azacitidine; beta Catenin; Cell Line, Tumor; Chromatin; Chromatin Assembly and Disassembly; Cytoskeletal Proteins; Decitabine; Desmoplakins; DNA-Binding Proteins; Enzyme Inhibitors; Fibrosarcoma; gamma Catenin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Reporter; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lymphoid Enhancer-Binding Factor 1; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; RNA, Messenger; Trans-Activators; Transcription Factors; Transcriptional Activation | 2004 |
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Separation; Chromatin; Colorectal Neoplasms; CpG Islands; Decitabine; Depsipeptides; DNA Methylation; Doxorubicin; Flow Cytometry; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Models, Genetic; Neuropeptides; Oligopeptides; Polymerase Chain Reaction; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Sulfites | 2003 |
Expression and regulation of tumor suppressor gene maspin in human bladder cancer.
Topics: Adult; Aged; Azacitidine; Carcinoma, Transitional Cell; Cell Line, Tumor; Cytoplasm; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, Reporter; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Luciferases; Male; Middle Aged; Promoter Regions, Genetic; Protein Biosynthesis; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Serpins; Transcriptional Activation; Urinary Bladder Neoplasms | 2004 |
Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells.
Topics: Animals; Azacitidine; Cell Lineage; Chromatin; Decitabine; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Heterozygote; Hydroxamic Acids; Liver; Luciferases; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Models, Genetic; NIH 3T3 Cells; Octamer Transcription Factor-3; Placenta; Polymerase Chain Reaction; Precipitin Tests; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Sulfites; Transcription Factors; Trophoblasts | 2004 |
Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Mutation; Promoter Regions, Genetic; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2004 |
Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.
Topics: Adult; Antigens, CD34; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Cells, Cultured; Decitabine; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; In Vitro Techniques; Methylation; Phenotype; Protein Synthesis Inhibitors; Thy-1 Antigens | 2004 |
[Effect of inhibitors for demethylation and histone deacetylase on proliferation of cell line K562 and expression of tumor related genes].
Topics: Azacitidine; Cell Cycle; Cell Division; Decitabine; DNA Methylation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; K562 Cells | 2004 |
Epigenetic modifications affect Dnmt3L expression.
Topics: Animals; Azacitidine; Base Sequence; Binding Sites; Cell Line; Chlorocebus aethiops; COS Cells; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation; Hydroxamic Acids; Luciferases; Mice; Molecular Sequence Data; NIH 3T3 Cells; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Sp1 Transcription Factor; Stem Cells; Thymus Gland | 2004 |
Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas.
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Azacitidine; Carrier Proteins; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Gene Deletion; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hydroxamic Acids; Membrane Proteins; Mutation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiolester Hydrolases; Transcription, Genetic | 2004 |
MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine.
Topics: Acetylation; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Breast Neoplasms; Chromatin; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger; Transcriptional Activation; Tumor Cells, Cultured | 2004 |
Effect of 5-azacytidine and trichostatin A on somatic centromere association in wheat.
Topics: Azacitidine; Centromere; Chromosome Pairing; DNA; Hydroxamic Acids; In Situ Hybridization; Microscopy, Fluorescence; Plant Roots; Polyploidy; Triticum | 2004 |
MEIS 1 expression is downregulated through promoter hypermethylation in AML1-ETO acute myeloid leukemias.
Topics: Acute Disease; Adult; Azacitidine; Bone Marrow; Case-Control Studies; Cell Line, Tumor; Core Binding Factor Alpha 2 Subunit; Decitabine; DNA Methylation; Down-Regulation; Homeodomain Proteins; Humans; Hydroxamic Acids; Leukemia, Myeloid; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Promoter Regions, Genetic; RNA, Messenger; RUNX1 Translocation Partner 1 Protein; Transcription Factors | 2004 |
Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth.
Topics: Azacitidine; beta Catenin; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; Desmoplakins; DNA Modification Methylases; gamma Catenin; Humans; Hydroxamic Acids; Lung Neoplasms; Neoplasm Proteins; Trans-Activators | 2004 |
Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines.
Topics: Acetylation; Apoptosis; Azacitidine; Butyrates; Cell Line, Tumor; Checkpoint Kinase 2; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Hodgkin Disease; Humans; Hydroxamic Acids; Lymphoma; Methylation; Protein Serine-Threonine Kinases; RNA, Messenger | 2004 |
The epigenetic stability of the locus control region-deficient IgH locus in mouse hybridoma cells is a clonally varying, heritable feature.
Topics: Animals; Azacitidine; CpG Islands; Enhancer Elements, Genetic; Enzyme Inhibitors; Genes, Immunoglobulin; Genetic Variation; Hybridomas; Hydroxamic Acids; Immunoglobulin Heavy Chains; Introns; Locus Control Region; Mice; Models, Genetic; Polymerase Chain Reaction; Recombinant Proteins; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA; Transcription, Genetic; Transcriptional Activation | 2004 |
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Topics: Amino Acid Sequence; Animals; Azacitidine; Base Sequence; Blotting, Northern; cdc42 GTP-Binding Protein; Cell Line; Cell Line, Tumor; COS Cells; Cytoplasm; Decitabine; DNA; DNA Methylation; Genes, Reporter; Genetic Variation; Genetic Vectors; Glutathione Transferase; GTP Phosphohydrolases; HeLa Cells; Humans; Hydroxamic Acids; Luciferases; Models, Genetic; Molecular Sequence Data; Myotonin-Protein Kinase; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Sp1 Transcription Factor; Transcription, Genetic; Transfection | 2004 |
Epigenetic modification regulates both expression of tumor-associated genes and cell cycle progressing in human colon cancer cell lines: Colo-320 and SW1116.
Topics: Acetylation; Azacitidine; Butyrates; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Decitabine; DNA; DNA Methylation; Gene Expression Regulation, Neoplastic; Genes, APC; Genes, p16; Histones; Humans; Hydroxamic Acids | 2004 |
Reduced expression of MYO18B, a candidate tumor-suppressor gene on chromosome arm 22q, in ovarian cancer.
Topics: Azacitidine; Carcinoma, Endometrioid; Case-Control Studies; Chromosomes, Human, Pair 22; Cystadenocarcinoma, Mucinous; Cystadenocarcinoma, Serous; Decitabine; DNA Methylation; DNA Mutational Analysis; Female; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Mutation, Missense; Myosin Heavy Chains; Ovarian Neoplasms; Ovary; Promoter Regions, Genetic; Tumor Cells, Cultured | 2004 |
Favorable neuroblastoma genes and molecular therapeutics of neuroblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Azacitidine; Boronic Acids; Caspases; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Nude; Mice, SCID; Neoplasm Proteins; Neuroblastoma; Phenylbutyrates; Proteasome Inhibitors; Transplantation, Heterologous; Tumor Cells, Cultured | 2004 |
Identification of a genomic fragment that directs hematopoietic-specific expression of Rac2 and analysis of the DNA methylation profile of the gene locus.
Topics: 5-Methylcytosine; Animals; Azacitidine; Base Sequence; Cell Line; Codon, Initiator; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation; Hematopoietic System; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; K562 Cells; Luciferases; Mice; Mice, Transgenic; Molecular Sequence Data; NIH 3T3 Cells; Promoter Regions, Genetic; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Recombinant Fusion Proteins; Regulatory Sequences, Nucleic Acid; Transcription Initiation Site; Transfection | 2004 |
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach.
Topics: Algorithms; Apoptosis; Azacitidine; Cell Division; Cell Line, Tumor; Cluster Analysis; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome; Humans; Hydroxamic Acids; Metallothionein; Methyltransferases; Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reproducibility of Results; RNA, Messenger; Transcriptional Activation | 2004 |
Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Azacitidine; Base Sequence; Blood Pressure; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Humans; Hydrocortisone; Hydroxamic Acids; Hypertension; Molecular Sequence Data; Procainamide; Promoter Regions, Genetic; Rats; Rats, Wistar; Receptors, Glucocorticoid; Transcription Factors; Transcription, Genetic | 2004 |
Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Decitabine; DNA Primers; Glycoproteins; Humans; Hydroxamic Acids; Loss of Heterozygosity; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous | 2005 |
Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins.
Topics: Acetylation; Azacitidine; Cell Line, Transformed; Cell Line, Tumor; DNA Methylation; DNA-Binding Proteins; Female; Gene Expression Regulation, Enzymologic; Gene Silencing; HeLa Cells; Histones; Humans; Hydroxamic Acids; O(6)-Methylguanine-DNA Methyltransferase; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Uterine Cervical Neoplasms | 2005 |
In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents.
Topics: Animals; Azacitidine; Chromatin; Decitabine; Diploidy; Genes, bcl-2; Green Fluorescent Proteins; Hematopoiesis; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; In Vitro Techniques; Karyotyping; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multipotent Stem Cells; Neurons; Spheroids, Cellular | 2005 |
Epigenetic regulation of protein phosphatase 2A (PP2A), lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Chemokines, C; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lymphokines; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Protein Phosphatase 2; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sialoglycoproteins; Tumor Cells, Cultured | 2004 |
Role of histone deacetylation in cell-specific expression of endothelial nitric-oxide synthase.
Topics: Azacitidine; Decitabine; DNA Methylation; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Promoter Regions, Genetic; Sp1 Transcription Factor | 2005 |
Co-culture of human CD34+ cells with mesenchymal stem cells increases the survival of CD34+ cells against the 5-aza-deoxycytidine- or trichostatin A-induced cell death.
Topics: Antigens, CD34; Apoptosis; Azacitidine; Cell Differentiation; Cell Proliferation; Cell Size; Cell Survival; Cells, Cultured; Coculture Techniques; Decitabine; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Mesenchymal Stem Cells; Tissue Engineering | 2005 |
Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; RNA, Messenger; Skin Neoplasms; Tumor Cells, Cultured; Up-Regulation | 2005 |
Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in gastrointestinal tumour.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Gastrointestinal Neoplasms; Humans; Hydroxamic Acids; Promoter Regions, Genetic; ras GTPase-Activating Proteins; Sequence Analysis, DNA | 2005 |
Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Cell Survival; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genome, Human; GTP Phosphohydrolases; Humans; Hydroxamic Acids; Introns; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; ras Proteins; RNA Interference; RNA, Small Interfering; Stomach Neoplasms; Transcriptional Activation | 2005 |
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Down-Regulation; Endometrial Neoplasms; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; RNA, Messenger | 2005 |
Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells.
Topics: Acetylation; Azacitidine; Cell Line, Transformed; Cell Line, Tumor; Cell Transformation, Viral; Chromatin; Decitabine; DNA Methylation; DNA-Binding Proteins; Fibroblasts; Humans; Hydroxamic Acids; Oncogene Proteins, Viral; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic; Repressor Proteins; Telomerase; Telomere | 2005 |
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Topics: Azacitidine; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Gene Expression; Gene Silencing; Histones; Humans; Hydroxamic Acids; Lysine; Methyl-CpG-Binding Protein 2; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors | 2005 |
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer.
Topics: Acetylation; Adenocarcinoma; Azacitidine; Base Sequence; Carcinoma, Pancreatic Ductal; Cell Differentiation; CpG Islands; DNA Methylation; Dual Specificity Phosphatase 6; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; Neoplasm Invasiveness; Pancreatic Neoplasms; Protein Tyrosine Phosphatases; Tumor Cells, Cultured | 2005 |
[Analysis of the methylation in the promoter of LRP15 gene and its expression].
Topics: Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; K562 Cells; Neoplasm Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic | 2005 |
Activation of CMV promoter-controlled glycosyltransferase and beta -galactosidase glycogenes by butyrate, tricostatin A, and 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; beta-Galactosidase; Butyrates; Cell Line, Tumor; Cricetinae; Cricetulus; Cytomegalovirus; Decitabine; DNA Modification Methylases; Drug Synergism; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Silencing; Glycosyltransferases; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger | 2005 |
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.
Topics: Acetylation; Animals; Azacitidine; beta-Galactosidase; Blotting, Western; Cell Line; Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Endothelium, Vascular; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Mice; Mice, Transgenic; Models, Genetic; Muscle, Smooth; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; Serine; Time Factors; Transgenes; Umbilical Veins | 2005 |
Inhibition of chromatin condensation prevents transgene silencing in a neural progenitor cell line transplanted to the rat brain.
Topics: Animals; Azacitidine; Brain; Brain Tissue Transplantation; Cell Line, Transformed; Chromatin Assembly and Disassembly; Decitabine; Enzyme Inhibitors; Female; Gene Silencing; Heterochromatin; Hydroxamic Acids; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Transgenes | 2005 |
Chromatin remodeling in plant cell culture: patterns of DNA methylation and histone H3 and H4 acetylation vary during growth of asynchronous potato cell suspensions.
Topics: 5-Methylcytosine; Acetylation; Azacitidine; Chromatin Assembly and Disassembly; Cytosine; DNA Methylation; Epigenesis, Genetic; Histones; Hydroxamic Acids; Solanum tuberosum; Transcription, Genetic | 2005 |
Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Receptors, Retinoic Acid; Tretinoin | 2005 |
Granulocyte-macrophage colony-stimulating factor induces de novo methylation of the p15 CpG island in hematopoietic cells.
Topics: Azacitidine; Base Sequence; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; CpG Islands; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Molecular Sequence Data; Myeloid Cells; Sequence Analysis, DNA | 2005 |
Epigenetic down-regulation of CDKN1C/p57KIP2 in pancreatic ductal neoplasms identified by gene expression profiling.
Topics: Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cluster Analysis; Cyclin-Dependent Kinase Inhibitor p57; Decitabine; Down-Regulation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene.
Topics: Azacitidine; Base Sequence; Blotting, Southern; Cell Line, Tumor; Computational Biology; CpG Islands; Decitabine; DNA Methylation; DNA Primers; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Luciferases; Membrane Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Plasmids; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA | 2005 |
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.
Topics: Adenocarcinoma; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Endometrial Neoplasms; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Polymerase Chain Reaction; Receptors, Progesterone; RNA, Messenger; Up-Regulation | 2005 |
5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.
Topics: Acylation; Azacitidine; Chromatin Assembly and Disassembly; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA Methylation; Enzyme Inhibitors; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; K562 Cells; Leukemia, Myeloid, Acute; Neoplasm Proteins; Promoter Regions, Genetic; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2006 |
Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription.
Topics: Acetylation; Azacitidine; Base Sequence; Chromatin; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, LH; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2005 |
Epigenetic regulation of lentiviral transgene vectors in a large animal model.
Topics: Animals; Animals, Genetically Modified; Azacitidine; Cells, Cultured; CpG Islands; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Fibroblasts; Genetic Vectors; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Histone Deacetylases; HIV-1; Hydroxamic Acids; Promoter Regions, Genetic; Proviruses; Swine | 2006 |
Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines.
Topics: Alleles; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Chromosomes, Human, Pair 1; Core Binding Factor Alpha 3 Subunit; CpG Islands; DNA Methylation; DNA, Complementary; Down-Regulation; Exons; Gene Deletion; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; In Situ Hybridization, Fluorescence; Lung Neoplasms; Polymerase Chain Reaction; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.
Topics: Acetylation; Androstadienes; Azacitidine; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Lysine; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Wortmannin | 2005 |
Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood.
Topics: Adolescent; Adult; Azacitidine; Brain Neoplasms; Caspase 8; Caspases; Child; Child, Preschool; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Silencing; Humans; Hydroxamic Acids; Infant; Male; Neuroectodermal Tumors, Primitive; Promoter Regions, Genetic; Rhabdoid Tumor; Teratoma; Tumor Suppressor Proteins | 2006 |
Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
Topics: Anticarcinogenic Agents; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Esophageal Neoplasms; Genistein; Glycine max; Humans; Hydroxamic Acids; Isoflavones; Isothiocyanates; O(6)-Methylguanine-DNA Methyltransferase; Receptors, Retinoic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfites; Sulfoxides; Tea; Thiocyanates | 2005 |
Down-regulation of DNA mismatch repair proteins in human and murine tumor spheroids: implications for multicellular resistance to alkylating agents.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Animals; Antineoplastic Agents, Alkylating; Azacitidine; Base Pair Mismatch; Blotting, Western; Carrier Proteins; Cell Line, Tumor; Cisplatin; DNA Methylation; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance, Neoplasm; Humans; Hydroxamic Acids; Mammary Neoplasms, Experimental; Mice; Mismatch Repair Endonuclease PMS2; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Spheroids, Cellular; Tumor Cells, Cultured | 2005 |
Molecular inhibition of histone deacetylation results in major enhancement of the production of IL-1beta in response to LPS.
Topics: Acetylation; Azacitidine; Decidua; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Histones; Humans; Hydroxamic Acids; In Vitro Techniques; Interleukin-1; Interleukin-10; Pregnancy; Tumor Necrosis Factor-alpha | 2006 |
Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging.
Topics: Animals; Azacitidine; Cell Line; Cell Proliferation; Cell Survival; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Silencing; Genes, Reporter; Hydroxamic Acids; Luciferases, Firefly; Muscle, Skeletal; Myoblasts, Cardiac; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Stem Cells; Tretinoin | 2006 |
Epigenetic and classical activation of Entamoeba histolytica heat shock protein 100 (EHsp100) expression.
Topics: Animals; Azacitidine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Protozoan; Entamoeba histolytica; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation; Heat-Shock Proteins; Hot Temperature; Hydroxamic Acids; Promoter Regions, Genetic | 2005 |
CpG methylation of the PAI-1 gene 5'-flanking region is inversely correlated with PAI-1 mRNA levels in human cell lines.
Topics: 5' Flanking Region; Azacitidine; Carcinoma, Squamous Cell; CpG Islands; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mouth Neoplasms; Plasminogen Activator Inhibitor 1; RNA, Messenger; Sequence Analysis, DNA; Time Factors; U937 Cells | 2005 |
BRCA1 promoter methylation in sporadic breast cancer is associated with reduced BRCA1 copy number and chromosome 17 aneusomy.
Topics: Aneuploidy; Antimetabolites, Antineoplastic; Azacitidine; BRCA1 Protein; Breast; Breast Neoplasms; Cell Line, Tumor; Chromosomes, Human, Pair 17; Decitabine; DNA Methylation; Female; Gene Dosage; Gene Expression; Genes, BRCA1; Humans; Hydroxamic Acids; Lymphocytes; Middle Aged; Promoter Regions, Genetic; RNA, Messenger | 2005 |
Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b.
Topics: Animals; Azacitidine; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Immunoprecipitation; Mice; NIH 3T3 Cells; Promoter Regions, Genetic; Proto-Oncogene Proteins; Trans-Activators; Transcription, Genetic | 2006 |
Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancer.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Epithelial Cells; Gene Deletion; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Histone Deacetylase Inhibitors; Homozygote; Humans; Hydroxamic Acids; Lung Neoplasms; Molecular Sequence Data; Transfection | 2006 |
A novel mechanism for acquired cisplatin-resistance: suppressed translation of death-associated protein kinase mRNA is insensitive to 5-aza-2'-deoxycitidine and trichostatin in cisplatin-resistant cervical squamous cancer cells.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Death-Associated Protein Kinases; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Protein Biosynthesis; Protein Synthesis Inhibitors; RNA, Messenger; Uterine Cervical Neoplasms | 2006 |
Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer.
Topics: Acetylation; Azacitidine; Breast; Breast Neoplasms; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2006 |
Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Chromatin; Chromosomal Instability; Colorectal Neoplasms; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Immunoprecipitation; Loss of Heterozygosity; Microsatellite Repeats; Protein Conformation | 2006 |
Expansion of human umbilical cord blood SCID-repopulating cells using chromatin-modifying agents.
Topics: Animals; Antigens, CD34; Azacitidine; Cells, Cultured; Chromatin; Cord Blood Stem Cell Transplantation; Cytokines; Decitabine; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Severe Combined Immunodeficiency; Thy-1 Antigens; Transplantation, Heterologous | 2006 |
Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia.
Topics: Azacitidine; Biomarkers; Cell Line; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Colonic Polyps; Decitabine; Humans; Hydroxamic Acids; Methylation; Polymerase Chain Reaction; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trans-Activators | 2006 |
High-frequency promoter hypermethylation of the deleted in liver cancer-1 gene in multiple myeloma.
Topics: Azacitidine; Base Sequence; Bone Marrow; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Female; GTPase-Activating Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Molecular Sequence Data; Multiple Myeloma; Neoplasm Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Suppressor Proteins; Up-Regulation | 2006 |
Angiostatic activity of DNA methyltransferase inhibitors.
Topics: Acetylation; Angiogenesis Inhibitors; Animals; Azacitidine; Cell Movement; Cytidine; DNA Modification Methylases; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Histones; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Melanoma, Experimental; Mice; Mice, Mutant Strains; Neovascularization, Pathologic; Neovascularization, Physiologic; Thrombospondin 1 | 2006 |
Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer.
Topics: Acetylation; Azacitidine; Blotting, Northern; Blotting, Southern; Carcinoma, Non-Small-Cell Lung; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Methyl-CpG-Binding Protein 2; Mutagenesis; Promoter Regions, Genetic; Sequence Analysis, DNA; Upstream Stimulatory Factors | 2006 |
Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer.
Topics: Azacitidine; Camptothecin; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucuronides; Glucuronosyltransferase; HCT116 Cells; HT29 Cells; Humans; Hydroxamic Acids; Irinotecan | 2006 |
Oncogenic HRAS suppresses clusterin expression through promoter hypermethylation.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Transformed; Clusterin; Decitabine; DNA Methylation; Genes, ras; Genes, Suppressor; Hydroxamic Acids; Promoter Regions, Genetic; Rats; Signal Transduction | 2006 |
Altered nuclear receptor corepressor expression attenuates vitamin D receptor signaling in breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Calcitriol; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Decitabine; Female; Humans; Hydroxamic Acids; Nuclear Proteins; Nuclear Receptor Co-Repressor 1; Receptors, Calcitriol; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured | 2006 |
Lytic induction and apoptosis of Epstein-Barr virus-associated gastric cancer cell line with epigenetic modifiers and ganciclovir.
Topics: Apoptosis; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Ganciclovir; Herpesvirus 4, Human; Humans; Hydroxamic Acids; Protein Processing, Post-Translational; Signal Transduction; Stomach Neoplasms; Virus Activation | 2007 |
Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells.
Topics: Acetylation; Antigens, Neoplasm; Azacitidine; Blotting, Western; Cell Line, Tumor; Corynebacterium; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Melanoma-Specific Antigens; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic | 2006 |
Identification of novel target genes by an epigenetic reactivation screen of renal cancer.
Topics: Adult; Aged; Azacitidine; Base Sequence; Carcinoma, Renal Cell; Cell Line, Tumor; Collagen Type I; Collagen Type I, alpha 1 Chain; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 3; Kidney Neoplasms; Male; Middle Aged; Molecular Sequence Data; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Up-Regulation | 2006 |
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer.
Topics: Azacitidine; Cell Line, Tumor; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Mucin-2; Mucins; Pancreatic Neoplasms; Promoter Regions, Genetic; RNA, Messenger | 2006 |
Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation.
Topics: Alcohol Dehydrogenase; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Liver Neoplasms; Promoter Regions, Genetic | 2006 |
Plasticity of Ly49g expression is due to epigenetics.
Topics: Acetylation; Antigens, Ly; Azacitidine; Cell Line; CpG Islands; Epigenesis, Genetic; Gene Expression Regulation; Histones; Hydroxamic Acids; Lectins, C-Type; Receptors, NK Cell Lectin-Like; Transcription, Genetic | 2007 |
Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes.
Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; Estrogen Antagonists; Estrogen Receptor alpha; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Promoter Regions, Genetic; Repressor Proteins; RNA, Messenger; Sin3 Histone Deacetylase and Corepressor Complex; Tamoxifen | 2006 |
Multiple mechanisms underlie the aberrant expression of the human kallikrein 6 gene in breast cancer.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Calcitriol; Cell Line, Tumor; Decitabine; Disease Progression; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Kallikreins; Promoter Regions, Genetic; Transcription, Genetic | 2006 |
Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts.
Topics: Azacitidine; Cells, Cultured; Collagen Type I; CpG Islands; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Fibroblasts; Gene Expression Regulation; Genes, Suppressor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Phenotype; Promoter Regions, Genetic; Proto-Oncogene Protein c-fli-1; Scleroderma, Systemic; Signal Transduction; Skin; Transfection | 2006 |
RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Targeting; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Promoter Regions, Genetic | 2006 |
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.
Topics: Azacitidine; Brain Neoplasms; Decitabine; DNA Methylation; Gene Expression; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Genome, Human; Glioma; Histones; Humans; Hydroxamic Acids; Nerve Tissue Proteins; Promoter Regions, Genetic | 2006 |
Estrogen receptor-alpha methylation predicts melanoma progression.
Topics: Age Factors; Azacitidine; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Estrogen Receptor alpha; Female; Gene Silencing; Humans; Hydroxamic Acids; Male; Melanoma; Middle Aged; Neoplasm Staging; Promoter Regions, Genetic; Sex Factors | 2006 |
Methylation mediated silencing of TMS1/ASC gene in prostate cancer.
Topics: Aged; Aged, 80 and over; Azacitidine; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Cytoskeletal Proteins; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation.
Topics: Acetylation; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cluster Analysis; DNA Methylation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Liver; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction.
Topics: Adenosine Triphosphatases; Antimetabolites, Antineoplastic; Apolipoproteins; Apolipoproteins D; Astrocytoma; Azacitidine; Biomarkers, Tumor; Brain Neoplasms; Cation Transport Proteins; Cell Adhesion Molecules, Neuronal; Decitabine; Disease Progression; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Guanine Nucleotide Exchange Factors; Histone Deacetylases; Humans; Hydroxamic Acids; Membrane Transport Proteins; Nerve Tissue Proteins; Nuclear Proteins; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Protein Synthesis Inhibitors; Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma.
Topics: Azacitidine; Brain Neoplasms; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Humans; Hydroxamic Acids; Up-Regulation | 2006 |
B29 gene silencing in pituitary cells is regulated by its 3' enhancer.
Topics: Animals; Azacitidine; CD79 Antigens; Cell Line; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunologic Factors; Mice; Octamer Transcription Factor-1; Pituitary Gland; Promoter Regions, Genetic; Rats; Trans-Activators; Transcription Factor Pit-1 | 2006 |
Epigenetic regulation of maspin expression in the human placenta.
Topics: Acetylation; Azacitidine; Cells, Cultured; Chromatin; CpG Islands; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Tumor Suppressor; Gestational Age; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Placenta; Pregnancy; Promoter Regions, Genetic; Serpins | 2006 |
Inhibitors of DNA methylation and histone deacetylation independently relieve AML1/ETO-mediated lysozyme repression.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Chromatin Assembly and Disassembly; Core Binding Factor Alpha 2 Subunit; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Silencing; Histone Acetyltransferases; Histones; Humans; Hydroxamic Acids; Muramidase; Protein Processing, Post-Translational; RNA, Small Interfering; U937 Cells; Up-Regulation | 2006 |
Inhibitors of histone deacetylases and DNA methyltransferases alter imprinted gene regulation in embryonic stem cells.
Topics: Animals; Azacitidine; Base Sequence; Cell Differentiation; Cell Line; Cell Proliferation; DNA Methylation; DNA Modification Methylases; DNA Primers; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Genomic Imprinting; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Pluripotent Stem Cells | 2006 |
An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis.
Topics: Apoptosis; Azacitidine; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Chromosomes, Human, Pair 10; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Male; Microtubule-Associated Proteins; Neoplasm Proteins; Neoplasms; Promoter Regions, Genetic; Recombinant Fusion Proteins; Transcription, Genetic | 2006 |
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity.
Topics: Acid Anhydride Hydrolases; Animals; Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Caspases; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Oxidoreductases; Promoter Regions, Genetic; Transgenes; Transplantation, Heterologous; Tumor Cells, Cultured; Tumor Suppressor Proteins; WW Domain-Containing Oxidoreductase | 2007 |
Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies.
Topics: Alleles; Animals; Azacitidine; Base Sequence; Case-Control Studies; Cells, Cultured; CpG Islands; Decitabine; DNA Methylation; DNA Primers; Epigenesis, Genetic; Female; Fetus; Gene Silencing; Genes, Recessive; Genomic Imprinting; Humans; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Myoblasts, Skeletal; Myopathy, Central Core; Pedigree; Point Mutation; Polymorphism, Single Nucleotide; Ryanodine Receptor Calcium Release Channel; Tissue Distribution | 2006 |
Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer.
Topics: Acetylation; Adenocarcinoma; Azacitidine; Biomarkers, Tumor; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Chromatin Immunoprecipitation; Colony-Forming Units Assay; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2007 |
Reversal of p15/INK4b hypermethylation in AML1/ETO-positive and -negative myeloid leukemia cell lines.
Topics: Azacitidine; Core Binding Factor Alpha 2 Subunit; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Myeloid; Oncogene Proteins, Fusion; RUNX1 Translocation Partner 1 Protein; Transcription, Genetic; Tumor Cells, Cultured | 2007 |
Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Apoptosis Regulatory Proteins; Azacitidine; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Neoplasm Proteins; Promoter Regions, Genetic; Protein Synthesis Inhibitors; RNA, Messenger; Stomach Neoplasms | 2006 |
Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle.
Topics: Animals; Azacitidine; Brain; Cattle; Cell Line; Cloning, Organism; CpG Islands; Decitabine; DNA; DNA Methylation; Epigenesis, Genetic; Female; Fetal Heart; Gene Expression; Gene Expression Regulation, Developmental; Genomic Imprinting; Hydroxamic Acids; Introns; Liver; Lung; Male; Molecular Sequence Data; Nuclear Transfer Techniques; Receptor, IGF Type 2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA | 2007 |
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Humans; Hydroxamic Acids; Lysophospholipids; Melanoma; Nerve Tissue Proteins; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; RNA-Binding Proteins; RNA, Messenger; Sphingosine | 2007 |
Expression of GAGE family proteins in malignant melanoma.
Topics: Antigens, Neoplasm; Autoantibodies; Azacitidine; Cell Line, Tumor; Humans; Hydroxamic Acids; Immunohistochemistry; Melanoma; Neoplasm Proteins; Recombinant Proteins; Skin Neoplasms | 2007 |
Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites.
Topics: Animals; Azacitidine; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Centromere; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Decitabine; DNA Methylation; Enzyme Inhibitors; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Hydroxamic Acids; Immunohistochemistry; Microscopy, Confocal; Nuclear Proteins; Protein Subunits; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors | 2007 |
Promoter methylation status of the Cyclin D2 gene is associated with poor prognosis in human epithelial ovarian cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cyclin D2; Cyclins; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Immunohistochemistry; Ovarian Neoplasms; Prognosis; Promoter Regions, Genetic; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.
Topics: 5' Flanking Region; Acetylation; Animals; Azacitidine; Base Sequence; Cell Line; Decitabine; DNA Methylation; DNA Primers; DNA-Binding Proteins; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Homeodomain Proteins; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Nanog Homeobox Protein; NIH 3T3 Cells; Octamer Transcription Factor-3; Pluripotent Stem Cells; Promoter Regions, Genetic; Trophoblasts | 2007 |
Transcriptional reactivation of murine cytomegalovirus ie gene expression by 5-aza-2'-deoxycytidine and trichostatin A in latently infected cells despite lack of methylation of the major immediate-early promoter.
Topics: Animals; Azacitidine; Decitabine; DNA Methylation; DNA, Viral; Enzyme Inhibitors; Gene Expression Regulation, Viral; Genes, Immediate-Early; Hydroxamic Acids; Immediate-Early Proteins; Mice; Models, Animal; Muromegalovirus; Promoter Regions, Genetic; Proviruses; Transcription, Genetic; Virus Activation | 2007 |
Differentiation-promoting drugs up-regulate NKG2D ligand expression and enhance the susceptibility of acute myeloid leukemia cells to natural killer cell-mediated lysis.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bryostatins; Cell Differentiation; Cell Line, Tumor; Cholecalciferol; Cytotoxicity, Immunologic; Decitabine; Flow Cytometry; GPI-Linked Proteins; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Killer Cells, Natural; Leukemia, Myeloid; Reverse Transcriptase Polymerase Chain Reaction; Tretinoin; Up-Regulation | 2007 |
Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Azacitidine; Cell Cycle; Cell Differentiation; Cell Proliferation; Decitabine; DNA, Mitochondrial; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Myeloid; Male; Middle Aged; Myelodysplastic Syndromes; Phenylbutyrates; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2007 |
Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Chromatin Immunoprecipitation; Epigenesis, Genetic; Histones; Hydroxamic Acids; Methyl-CpG-Binding Protein 2; Methylation; Mice; Models, Biological; Neurons; Promoter Regions, Genetic; Receptors, Opioid, mu; RNA, Small Interfering; Transcription, Genetic | 2007 |
Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Neoplasm Invasiveness; Promoter Regions, Genetic; Serine Proteinase Inhibitors | 2007 |
Epigenetic regulation (DNA methylation, histone modifications) of the 11p15 mucin genes (MUC2, MUC5AC, MUC5B, MUC6) in epithelial cancer cells.
Topics: Acylation; Azacitidine; Chromosomes, Human, Pair 11; Decitabine; DNA Methylation; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucin-5B; Mucin-6; Mucins; Neoplasms; Tumor Cells, Cultured | 2007 |
Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Methylation; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic | 2007 |
Identification of epigenetically silenced genes in tumor endothelial cells.
Topics: Azacitidine; Caco-2 Cells; Clusterin; Colonic Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Endothelial Cells; Epigenesis, Genetic; Fibrillin-1; Fibrillins; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microfilament Proteins; Neovascularization, Pathologic; Oxidoreductases Acting on Sulfur Group Donors; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Thioredoxins | 2007 |
Trichostatin A, sodium butyrate, and 5-aza-2'-deoxycytidine alter the expression of glucocorticoid receptor alpha and beta isoforms in Hut-78 T- and Raji B-lymphoma cell lines.
Topics: Antineoplastic Agents; Azacitidine; Blotting, Western; Butyrates; Cell Line, Tumor; Decitabine; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Lymphoma; Polymerase Chain Reaction; Receptors, Glucocorticoid; Reverse Transcription | 2007 |
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Analysis of Variance; Azacitidine; Blotting, Western; Cartilage, Articular; Case-Control Studies; Chondrocytes; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Gene Expression; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Knee Joint; Leptin; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Middle Aged; Osteoarthritis; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering | 2007 |
Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing.
Topics: Acetylation; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation; Gene Silencing; Histones; Hydroxamic Acids; Leukemia L1210; Lysine; Methylation; Mice; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Protein Processing, Post-Translational | 2007 |
[Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine].
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Ovariectomy; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2006 |
De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists.
Topics: Azacitidine; Blotting, Northern; Cell Line; Cycloheximide; Decitabine; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Herpesvirus 4, Human; Herpesvirus 8, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immediate-Early Proteins; Protein Biosynthesis; Protein Kinase C; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Viral; Tetradecanoylphorbol Acetate; Trans-Activators; Viral Proteins; Virus Activation | 2007 |
The comparative effects of gene modulators on thyroid-specific genes and radioiodine uptake.
Topics: Aged; Apoptosis; Azacitidine; Cell Line, Tumor; Gene Expression Regulation; Humans; Hydroxamic Acids; Iodine Radioisotopes; Proteins; RNA, Messenger; Thyroid Gland; Thyroid Neoplasms; Time Factors; Tretinoin | 2007 |
Suppression of DPYD expression in RKO cells via DNA methylation in the regulatory region of the DPYD promoter: a potentially important epigenetic mechanism regulating DPYD expression.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; Dihydrouracil Dehydrogenase (NADP); DNA Methylation; DNA Primers; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Sp1 Transcription Factor; Suppression, Genetic | 2007 |
Effects of chromatin-modifying agents on CD34+ cells from patients with idiopathic myelofibrosis.
Topics: Antigens, CD34; Antimetabolites, Antineoplastic; Azacitidine; Cell Movement; Chromatin; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Hematopoietic Stem Cells; Homozygote; Humans; Hydroxamic Acids; Mutation; Primary Myelofibrosis; Protein Synthesis Inhibitors; Receptors, CXCR4; Stem Cells | 2007 |
The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma.
Topics: Amino Acid Sequence; Animals; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Interferon-alpha; Liver Neoplasms; Male; Mice; Mice, Nude; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Sequence Homology, Amino Acid | 2007 |
Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene.
Topics: Azacitidine; Base Sequence; Butyrates; Cell Proliferation; Cells, Cultured; CpG Islands; Cyclin A; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Endothelial Cells; Gene Expression Regulation; Homocysteine; Humans; Hydroxamic Acids; Molecular Sequence Data; Promoter Regions, Genetic; Transfection | 2007 |
Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours.
Topics: Animals; Antigen Presentation; Apoptosis; Azacitidine; Enzyme Inhibitors; Epigenesis, Genetic; Genes, MHC Class I; Histones; Human papillomavirus 16; Humans; Hydroxamic Acids; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Papillomavirus Infections; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Up-Regulation | 2008 |
Trichostatin A and 5 Aza-2' deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR.
Topics: 3' Untranslated Regions; Antigens, Surface; Azacitidine; Base Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Decitabine; ELAV Proteins; ELAV-Like Protein 1; Enzyme Inhibitors; Epigenesis, Genetic; Estrogen Receptor alpha; Estrogen Receptor Modulators; Female; Humans; Hydroxamic Acids; Immunoprecipitation; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Transfection | 2008 |
Downregulation of microRNAs-143 and -145 in B-cell malignancies.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Burkitt Lymphoma; Cell Line, Tumor; Cell Survival; Decitabine; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lymphoma, B-Cell; MicroRNAs; RNA, Neoplasm; Tumor Cells, Cultured | 2007 |
[The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor].
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenoma; Adult; Aged; Azacitidine; Cell Line, Tumor; Colorectal Neoplasms; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glycoproteins; HCT116 Cells; Humans; Hydroxamic Acids; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Genetic and epigenetic changes in the common 1p36 deletion in neuroblastoma tumours.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Cell Line, Tumor; Chromosome Deletion; Chromosomes, Human, Pair 1; Class I Phosphatidylinositol 3-Kinases; Decitabine; DNA Methylation; DNA Mutational Analysis; DNA-Binding Proteins; DNA, Neoplasm; Exons; Genetic Variation; Histones; Humans; Hydroxamic Acids; Mutation; Neuroblastoma; Phosphatidylinositol 3-Kinases; Polymorphism, Genetic; Retinol-Binding Proteins, Cellular; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins; Up-Regulation | 2007 |
Regulation of the CLDN3 gene in ovarian cancer cells.
Topics: Azacitidine; Binding Sites; Cell Line, Tumor; Claudin-3; Claudin-4; CpG Islands; Decitabine; DNA Methylation; Female; Humans; Hydroxamic Acids; Membrane Proteins; Mutagenesis, Site-Directed; Ovarian Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Sp3 Transcription Factor | 2007 |
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.
Topics: Abnormalities, Multiple; Acetylation; Azacitidine; B-Lymphocytes; Case-Control Studies; Cell Line, Transformed; Cell Transformation, Viral; Cells, Cultured; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Recessive; Histones; Humans; Hydroxamic Acids; Immunologic Deficiency Syndromes; Intellectual Disability; Male; Mutation; Neurons; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Time Factors | 2008 |
Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Cell Line, Tumor; Chromatin; CpG Islands; DNA Methylation; DNA, Neoplasm; Drug Synergism; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Suppressor Protein p14ARF | 2007 |
DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines.
Topics: Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Estrogen Receptor alpha; Estrogen Receptor beta; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Receptors, Progesterone | 2008 |
Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Genome, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Multiple Myeloma; Transcription, Genetic; Tumor Cells, Cultured | 2008 |
Epigenetic-based treatments emphasize the biologic differences of core-binding factor acute myeloid leukemias.
Topics: Adult; Azacitidine; Biomarkers, Tumor; Chromatin Assembly and Disassembly; Chromosome Inversion; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Core Binding Factor Alpha 2 Subunit; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Mutation; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RUNX1 Translocation Partner 1 Protein; Translocation, Genetic; Tumor Cells, Cultured; U937 Cells | 2008 |
Differential epigenetic regulation of Aiolos expression in human tumoral cell lines and primary cells.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Cell Culture Techniques; Cell Line, Tumor; Chromatin; CpG Islands; Decitabine; DNA Methylation; Drug Combinations; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Histones; Humans; Hydroxamic Acids; Ikaros Transcription Factor; Jurkat Cells; Neoplasms; Promoter Regions, Genetic; Transcription Factors; Transcriptional Activation; U937 Cells | 2008 |
Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro.
Topics: Acetylation; Azacitidine; CD4 Antigens; Cell Line; Chromatin Immunoprecipitation; DNA Methylation; DNA-Cytosine Methylases; Gene Silencing; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Receptors, CCR5; Receptors, CXCR4; RNA, Small Interfering; Simian Immunodeficiency Virus | 2008 |
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens; Female; Flow Cytometry; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tamoxifen; Trefoil Factor-1; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2008 |
Epigenetic silencing of maspin expression occurs early in the conversion of keratocytes to fibroblasts.
Topics: Azacitidine; Base Sequence; Blotting, Western; Cell Differentiation; Cells, Cultured; Corneal Stroma; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Eye Proteins; Fibroblasts; Gene Silencing; Humans; Hydroxamic Acids; Molecular Sequence Data; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serpins | 2008 |
Homocysteine-induced extracellular superoxide dismutase and its epigenetic mechanisms in monocytes.
Topics: Azacitidine; Base Sequence; Cardiovascular Diseases; Cells, Cultured; Cholesterol; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Primers; Epigenesis, Genetic; Foam Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Homocysteine; Humans; Hydrogen Peroxide; Hydroxamic Acids; Lipoproteins, LDL; Methyl-CpG-Binding Protein 2; Models, Biological; Monocytes; RNA, Messenger; Superoxide Dismutase | 2008 |
Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; DNA Restriction Enzymes; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genome, Human; Humans; Hydroxamic Acids; Male; Membrane Proteins; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Stomach Neoplasms | 2008 |
Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors.
Topics: Acetylation; Animals; Azacitidine; Butyrates; Callithrix; Cell Line; Chromatin Immunoprecipitation; Decitabine; DNA Modification Methylases; DNA, Viral; Enzyme Inhibitors; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Tetradecanoylphorbol Acetate; Valproic Acid; Virus Activation; Virus Latency | 2008 |
SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome.
Topics: Alleles; Azacitidine; Base Sequence; Cell Line; Decitabine; DNA Methylation; DNA Primers; Enzyme Inhibitors; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Silencing; Histones; Humans; Hydroxamic Acids; Models, Biological; Mutation; Naphthalenes; Niacinamide; Promoter Regions, Genetic; Pyrones; Sirtuin 1; Sirtuins; Trinucleotide Repeat Expansion | 2008 |
The novel gene LRP15 is regulated by DNA methylation and confers increased efficiency of DNA repair of ultraviolet-induced DNA damage.
Topics: Animals; Azacitidine; Base Sequence; Cell Proliferation; Chlorocebus aethiops; Comet Assay; COS Cells; Cyclin B; Cyclin B1; Decitabine; DNA Damage; DNA Methylation; DNA Repair; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Hydroxamic Acids; Molecular Sequence Data; Neoplasm Proteins; RNA, Messenger; Ultraviolet Rays | 2008 |
[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor].
Topics: Adaptor Proteins, Signal Transducing; Adenocarcinoma; Adenoma; Adult; Aged; Azacitidine; Biomarkers, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Eye Proteins; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Male; Membrane Proteins; Middle Aged; RNA, Messenger | 2007 |
DNA methylation and histone modifications cause silencing of Wnt antagonist gene in human renal cell carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Immunoprecipitation; Kidney Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Wnt Proteins | 2008 |
Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells.
Topics: Acetylation; Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromones; CpG Islands; Decitabine; Deubiquitinating Enzyme CYLD; Down-Regulation; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, Tumor Suppressor; Genistein; Histones; Humans; Hydroxamic Acids; Male; Methylation; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytoestrogens; Prostatic Neoplasms; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1; Sirtuins; Tumor Suppressor Proteins; Up-Regulation | 2008 |
Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Exons; Female; Gene Expression Regulation, Neoplastic; Gestational Trophoblastic Disease; Humans; Hydroxamic Acids; Octamer Transcription Factor-3; Placenta; Pregnancy; Promoter Regions, Genetic; RNA, Messenger | 2008 |
Epigenetic remodeling during arsenical-induced malignant transformation.
Topics: Acetylation; Arsenicals; Azacitidine; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Decitabine; Environmental Exposure; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Teratogens; Urinary Bladder Neoplasms; Urothelium | 2008 |
Internuclear gene silencing in Phytophthora infestans is established through chromatin remodelling.
Topics: Algal Proteins; Azacitidine; Chromatin; Chromatin Assembly and Disassembly; DNA Methylation; DNA-Cytosine Methylases; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Histone Deacetylase Inhibitors; Hydroxamic Acids; Phytophthora; Proteins | 2008 |
Assessment of NORE1A as a putative tumor suppressor in human neuroblastoma.
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Bromodeoxyuridine; Cell Line, Tumor; DNA Methylation; Down-Regulation; Ganglioneuroma; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Monomeric GTP-Binding Proteins; Neuroblastoma; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2008 |
TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; CDC2 Protein Kinase; Cell Differentiation; Decitabine; Epigenesis, Genetic; Granulocyte Colony-Stimulating Factor; Hydroxamic Acids; Interleukin-3; Mice; Myeloid Progenitor Cells; Oncogene Proteins; Oncogene Proteins, Fusion; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Proto-Oncogene Protein c-ets-1; RNA-Binding Protein FUS; Transcription Factors; Transcriptional Regulator ERG | 2008 |
Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation.
Topics: Animals; Azacitidine; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Histones; Hydroxamic Acids; Lysine; Mice; Oocytes; Sheep; Zygote | 2008 |
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Adenosylhomocysteinase; Apoptosis; Azacitidine; beta Catenin; Colorectal Neoplasms; Decitabine; Dishevelled Proteins; DNA Methylation; DNA Modification Methylases; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Oligonucleotide Array Sequence Analysis; Phosphoproteins; Promoter Regions, Genetic; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transfection; Wnt Proteins | 2008 |
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Topics: Animals; Azacitidine; Cells, Cultured; Chromatin; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Male; Mice; Pituitary Gland; Protein Processing, Post-Translational; Up-Regulation | 2008 |
Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells.
Topics: Acetylation; Adult; Aged; Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Loss of Heterozygosity; Male; Middle Aged; Promoter Regions, Genetic; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2008 |
Increased pre-implantation development of cloned bovine embryos treated with 5-aza-2'-deoxycytidine and trichostatin A.
Topics: Animals; Azacitidine; Blastocyst; Cattle; Cloning, Organism; Decitabine; Drug Therapy, Combination; Embryonic Development; Enzyme Inhibitors; Hydroxamic Acids; Nuclear Transfer Techniques | 2008 |
Incubation with somatostatin, 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Prostatic Neoplasms; Receptors, Somatostatin; RNA, Messenger; Somatostatin; Up-Regulation | 2008 |
Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines.
Topics: Acetylation; Antigens, CD; Azacitidine; Cadherins; Cell Line, Tumor; Chromatin Immunoprecipitation; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic | 2008 |
A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts.
Topics: Azacitidine; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Female; Granulocyte Precursor Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; I-kappa B Kinase; Leukemia, Myeloid, Acute; Male; Middle Aged; NF-kappa B; Valproic Acid | 2008 |
DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Barrett Esophagus; Cell Transformation, Neoplastic; CpG Islands; Decitabine; Disease Progression; DNA Methylation; DNA, Neoplasm; Down-Regulation; Epigenesis, Genetic; Esophageal Neoplasms; Gene Expression Regulation, Enzymologic; Glutathione Peroxidase; Glutathione Transferase; Humans; Hydroxamic Acids; Middle Aged; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 2009 |
Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.
Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Caspases; Cell Division; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; Digestive System Neoplasms; DNA Methylation; Epigenesis, Genetic; G2 Phase; Gene Silencing; Humans; Hydroxamic Acids; Liver Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Transfection; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Ubiquitin Thiolesterase | 2008 |
Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Cell Line, Tumor; Colonic Neoplasms; Decitabine; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Profiling; Histones; Humans; Hydroxamic Acids; RNA, Messenger; Sequence Analysis, DNA; Stomach Neoplasms | 2008 |
Epigenetic mechanisms and Sp1 regulate mitochondrial citrate carrier gene expression.
Topics: Acetylation; Animals; Anion Transport Proteins; Azacitidine; Base Sequence; Cell Line; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression; Genes, Reporter; Histones; Humans; Hydroxamic Acids; Mice; Mitochondrial Proteins; Organic Anion Transporters; Promoter Regions, Genetic; Rats; Sp1 Transcription Factor | 2008 |
[Effect of decitabine combined with Trichostatin A on MDS cell line SKM-1 in vitro].
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; fas Receptor; Humans; Hydroxamic Acids; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Myelodysplastic Syndromes; Survivin | 2008 |
LRRC3B, encoding a leucine-rich repeat-containing protein, is a putative tumor suppressor gene in gastric cancer.
Topics: Acetylation; Animals; Azacitidine; Base Sequence; Blotting, Southern; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Primers; Down-Regulation; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasm Proteins; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms | 2008 |
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) expression is increased by the histone deacetylase inhibitor trichostatin A.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; Early Growth Response Protein 1; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Growth Differentiation Factor 15; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasm Proteins; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Sp1 Transcription Factor; Up-Regulation | 2008 |
Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma.
Topics: Azacitidine; Carrier Proteins; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; Esophageal Neoplasms; Gene Expression Profiling; Gene Silencing; Genes, Tumor Suppressor; Glioma; Heat-Shock Proteins; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Melanoma; Membrane Proteins; Microfilament Proteins; Neuropeptides; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Aberrant methylation of candidate tumor suppressor genes in neuroblastoma.
Topics: Azacitidine; Child; Child, Preschool; Decitabine; DNA Methylation; Epigenesis, Genetic; Genes, Tumor Suppressor; Genome; Humans; Hydroxamic Acids; Infant; Neuroblastoma; Polymerase Chain Reaction; RNA, Messenger | 2009 |
Comparative epigenomics of human and mouse mammary tumors.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Databases, Genetic; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; Genes, Tumor Suppressor; Glycoproteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Mammary Neoplasms, Animal; Mice; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Structure-Activity Relationship; Tissue Inhibitor of Metalloproteinase-3 | 2009 |
Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells.
Topics: Acetylation; Azacitidine; Cell Hypoxia; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histocompatibility Antigens; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Methylation; Neoplasm Proteins; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Stomach Neoplasms; Transcription, Genetic | 2009 |
Promoter hypermethylation is not the major mechanism for inactivation of the FBXW7 beta-form in human gliomas.
Topics: Azacitidine; Base Sequence; Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; DNA Methylation; DNA Mutational Analysis; Enzyme Inhibitors; F-Box Proteins; F-Box-WD Repeat-Containing Protein 7; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioma; Humans; Hydroxamic Acids; Isoenzymes; Molecular Sequence Data; Promoter Regions, Genetic; Ubiquitin-Protein Ligases | 2008 |
Aberrant methylation of human L- and M-fructose 1,6-bisphosphatase genes in cancer.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Cell Line, Tumor; DNA Methylation; Female; Fructose-Bisphosphatase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Middle Aged; Neoplasms; Promoter Regions, Genetic | 2008 |
AZGP1 autoantibody predicts survival and histone deacetylase inhibitors increase expression in lung adenocarcinoma.
Topics: Acetylation; Adenocarcinoma; Adipokines; Adult; Aged; Aged, 80 and over; Autoantibodies; Azacitidine; Biomarkers, Tumor; Carrier Proteins; Case-Control Studies; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycoproteins; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Lung Neoplasms; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Cells, Cultured | 2008 |
Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; Drug Administration Schedule; Estrogen Receptor Modulators; Humans; Hydroxamic Acids; Receptors, Estrogen; RNA, Messenger; Tamoxifen | 2009 |
[Effects of 5-Aza-2'-deoxycytidine and trichostatin A on DNA methylation and expression of hMLH1 in ovarian cancer cell line COC1/DDP].
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cisplatin; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MutL Protein Homolog 1; Nuclear Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; RNA, Messenger | 2008 |
Hypomethylating drugs convert HA-1-negative solid tumors into targets for stem cell-based immunotherapy.
Topics: Acetylation; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Hydroxamic Acids; Immunotherapy; Minor Histocompatibility Antigens; Neoplasm Proteins; Neoplasms; Oligopeptides; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA, Messenger; RNA, Neoplasm; T-Lymphocytes, Cytotoxic; Transcription, Genetic | 2009 |
Promoter CpG methylation in cancer cells contributes to the regulation of MUC4.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Mucin-4; Neoplasms; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
[The role of DNA methylation and histone modifications in structural maintainance of heterochromatin domains (chromocenters)].
Topics: Acetylation; Animals; Azacitidine; Cell Line; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; DNA Methylation; Enzyme Inhibitors; Heterochromatin; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Mice; Microscopy, Electron; Protein Structure, Tertiary | 2008 |
The developmental potential of mouse somatic cell nuclear-transferred oocytes treated with trichostatin A and 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blastocyst; Decitabine; DNA Methylation; Embryo Transfer; Embryonic Development; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Methyltransferases; Mice; Nuclear Transfer Techniques; Oocytes | 2009 |
Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Epigenesis, Genetic; Gastrointestinal Tract; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Oncostatin M Receptor beta Subunit; Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2009 |
Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study.
Topics: Analysis of Variance; Apoptosis; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; Endocrine Gland Neoplasms; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Pancreatic Neoplasms | 2009 |
Promoter CpG island hypermethylation- and H3K9me3 and H3K27me3-mediated epigenetic silencing targets the deleted in colon cancer (DCC) gene in colorectal carcinogenesis without affecting neighboring genes on chromosomal region 18q21.
Topics: Azacitidine; Cell Line, Tumor; Chromosomes, Human, Pair 18; Colonic Neoplasms; CpG Islands; DCC Receptor; Decitabine; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Receptors, Cell Surface; Tumor Suppressor Proteins | 2009 |
Lysyl oxidase-like 2 promotes migration in noninvasive breast cancer cells but not in normal breast epithelial cells.
Topics: Amino Acid Oxidoreductases; Azacitidine; Blotting, Western; Breast Neoplasms; Catalysis; Cell Line; Cell Line, Tumor; Decitabine; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Immunohistochemistry; Mammary Glands, Human; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells.
Topics: Azacitidine; Cell Growth Processes; Cell Line, Tumor; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Estrogen Receptor beta; Female; Histone Acetyltransferases; Humans; Hydroxamic Acids; Ovarian Neoplasms; Promoter Regions, Genetic | 2009 |
Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.
Topics: Apoptosis; Azacitidine; Benzamides; Butyrates; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Survival; Decitabine; DNA Modification Methylases; DNA Repair; Drug Synergism; Flow Cytometry; Fluorescent Antibody Technique; Fluorobenzenes; Histone Acetyltransferases; HL-60 Cells; Humans; Hydroxamic Acids; Immunohistochemistry; K562 Cells; Leukemia, Myeloid; Myelodysplastic Syndromes; Phenanthrenes; Phthalazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Pyridines; U937 Cells | 2009 |
Epigenetic hierarchy governing Nestin expression.
Topics: Acetylation; Animals; Azacitidine; Carcinoma, Embryonal; Cell Line; Chromatin; Chromatin Immunoprecipitation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryonic Stem Cells; Enhancer Elements, Genetic; Epigenesis, Genetic; Histones; Hydroxamic Acids; Intermediate Filament Proteins; Introns; Mice; Nerve Tissue Proteins; Nestin; Promoter Regions, Genetic; Transcription, Genetic; Tretinoin | 2009 |
Glucocorticoid receptor alpha and beta variant expression is associated with ASF/SF2 splicing factor upregulation in HT-29 colon cancer and MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Butyrates; Colonic Neoplasms; Decitabine; Enzyme Inhibitors; HT29 Cells; Humans; Hydroxamic Acids; Nuclear Proteins; Receptors, Glucocorticoid; RNA-Binding Proteins; Serine-Arginine Splicing Factors | 2009 |
Expression level and DNA methylation status of glutathione-S-transferase genes in normal murine prostate and TRAMP tumors.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Drug Combinations; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutathione S-Transferase pi; Glutathione Transferase; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Metastasis; Prostate; Prostatic Neoplasms; RNA, Messenger | 2009 |
Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-2 | 2009 |
CpG island methylation affects accessibility of the proximal BRCA1 promoter to transcription factors.
Topics: Adenocarcinoma; Azacitidine; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Genes, BRCA1; Humans; Hydroxamic Acids; Neoplasm Proteins; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2010 |
Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1.
Topics: Acetylation; Analysis of Variance; Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Inhibitors; Exons; Hippocampus; Histone Deacetylase 1; Histone Deacetylases; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Methyl-CpG-Binding Protein 2; Methylation; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Messenger; Time Factors; Transcription Factors | 2009 |
Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.
Topics: Adult; Animals; Antigens, CD34; Azacitidine; Cell Culture Techniques; Cell Division; Cells, Cultured; Cord Blood Stem Cell Transplantation; Cytokines; Decitabine; Enzyme Inhibitors; Epigenesis, Genetic; Fetal Blood; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Thy-1 Antigens; Transplantation, Heterologous; Transplantation, Homologous | 2009 |
Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer.
Topics: Acetylation; Animals; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatin; Cystatin M; Decitabine; Disease Progression; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Mice; Mice, Nude; Neoplasms, Experimental; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous | 2009 |
Epigenetic silencing of TTF-1/NKX2-1 through DNA hypermethylation and histone H3 modulation in thyroid carcinomas.
Topics: Azacitidine; Base Sequence; Carcinoma, Papillary; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Primers; Epigenesis, Genetic; Gene Expression Profiling; Gene Silencing; Histones; Humans; Hydroxamic Acids; Nuclear Proteins; RNA, Messenger; RNA, Neoplasm; Thyroid Gland; Thyroid Neoplasms; Thyroid Nuclear Factor 1; Transcription Factors | 2009 |
Epigenetic modifiers exacerbate oxidative stress in renal proximal tubule cells.
Topics: Animals; Antifungal Agents; Antimetabolites, Antineoplastic; Azacitidine; Cell Survival; Cells, Cultured; Decitabine; Hydroxamic Acids; Kidney Tubules, Proximal; Mice; Oxidative Stress; Reactive Oxygen Species | 2009 |
Distinct roles for histone methyltransferases G9a and GLP in cancer germ-line antigen gene regulation in human cancer cells and murine embryonic stem cells.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; Embryonic Stem Cells; Gene Expression; Gene Expression Regulation; Histocompatibility Antigens; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Mice; Mice, Knockout | 2009 |
Xenoestrogen-induced epigenetic repression of microRNA-9-3 in breast epithelial cells.
Topics: Azacitidine; Breast; Cell Line, Tumor; Cells, Cultured; CpG Islands; Decitabine; Diethylstilbestrol; DNA Methylation; Epigenesis, Genetic; Epithelial Cells; Fluorescent Antibody Technique; Gene Expression; Gene Expression Profiling; Gene Regulatory Networks; Humans; Hydroxamic Acids; MicroRNAs; Models, Biological; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2009 |
Repression of induced apoptosis in the 2-cell bovine embryo involves DNA methylation and histone deacetylation.
Topics: 5-Methylcytosine; Animals; Apoptosis; Azacitidine; Blastocyst; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; Cytosine; Decitabine; DNA Fragmentation; DNA Methylation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids | 2009 |
Regulation of Toll-like receptor 4-associated MD-2 in intestinal epithelial cells: a comprehensive analysis.
Topics: Azacitidine; Caco-2 Cells; Cell Polarity; DNA Methylation; Humans; Hydroxamic Acids; Inflammatory Bowel Diseases; Intestinal Mucosa; Lipopolysaccharides; Lymphocyte Antigen 96; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Toll-Like Receptor 4; Transcriptional Activation | 2010 |
LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromosome Deletion; Chromosome Mapping; Chromosomes, Human, Pair 11; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Guanine Nucleotide Exchange Factors; Humans; Hydroxamic Acids; Male; Nucleic Acid Hybridization; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Rho Guanine Nucleotide Exchange Factors; Transfection; Tumor Suppressor Proteins | 2009 |
[Effects of 5-Aza-2'-deoxycytidine and trichostatin A on P16, hMLH1 and MGMT genes and DNA methylation in human gastric cancer cells].
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Genes, p16; Humans; Hydroxamic Acids; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Suppressor Proteins | 2009 |
Impaired active demethylation of the paternal genome in pronuclear-stage rat zygotes produced by in vitro fertilization or intracytoplasmic sperm injection.
Topics: Animals; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Fertilization in Vitro; Genome; Hydroxamic Acids; Male; Oocytes; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Sperm Injections, Intracytoplasmic; Zygote | 2010 |
MeCP2/H3meK9 are involved in IL-6 gene silencing in pancreatic adenocarcinoma cell lines.
Topics: Adenocarcinoma; Azacitidine; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; DNA; DNA Methylation; Gene Silencing; Humans; Hydroxamic Acids; Interleukin-6; Methyl-CpG-Binding Protein 2; NF-kappa B; Pancreatic Neoplasms | 2009 |
Correction of the abnormal trafficking of primary myelofibrosis CD34+ cells by treatment with chromatin-modifying agents.
Topics: Animals; Antigens, CD34; Azacitidine; Bone Marrow; Chromatin; Decitabine; Down-Regulation; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Primary Myelofibrosis; Receptors, CXCR4; Spleen | 2009 |
Wnt antagonist gene DKK2 is epigenetically silenced and inhibits renal cancer progression through apoptotic and cell cycle pathways.
Topics: Adult; Aged; Apoptosis; Azacitidine; Carcinoma, Renal Cell; Cell Cycle; Chromatin Immunoprecipitation; Decitabine; Disease Progression; Female; Gene Silencing; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Male; Middle Aged; Wnt Proteins | 2009 |
Demonstration of all-or-none loss of imprinting in mRNA expression in single cells.
Topics: Alleles; Azacitidine; Cell Cycle Proteins; Cells, Cultured; Decitabine; Gene Expression; Genomic Imprinting; Humans; Hydroxamic Acids; RNA, Messenger; Transcription Factors; Trophoblasts; Tumor Suppressor Proteins | 2009 |
Expression and function of CD9 in melanoma cells.
Topics: Animals; Antigens, CD; Azacitidine; Blotting, Western; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Infant, Newborn; Melanocytes; Melanoma; Membrane Glycoproteins; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tetraspanin 29; Transfection | 2010 |
Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells.
Topics: Acetylation; Azacitidine; Blotting, Western; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoprecipitation; Lysine; Polymerase Chain Reaction; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Cells, Cultured | 2009 |
Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation.
Topics: Azacitidine; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Neoplasm; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; MicroRNAs; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; Chromatin Assembly and Disassembly; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Phenylbutyrates; Receptors, Prostaglandin E; RNA, Messenger; Tumor Cells, Cultured; Vorinostat | 2009 |
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.
Topics: Azacitidine; Cell Adhesion Molecule-1; Cell Adhesion Molecules; Cell Line, Tumor; DNA Methylation; Gene Expression Regulation, Leukemic; Histones; Humans; Hydroxamic Acids; Immunoglobulins; Leukemia, Myeloid, Acute; Membrane Proteins; Mutation; Myeloid-Lymphoid Leukemia Protein; Nerve Tissue Proteins; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Receptors, Retinoic Acid; Sequence Analysis, DNA; Tissue Inhibitor of Metalloproteinase-3; Transcription, Genetic; Translocation, Genetic; Tumor Suppressor Proteins | 2009 |
Role of histone modifications and DNA methylation in the regulation of O6-methylguanine-DNA methyltransferase gene expression in human stomach cancer cells.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Suppressor Proteins | 2010 |
Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.
Topics: Azacitidine; Cell Cycle Proteins; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Lung Neoplasms; Neoplasms, Squamous Cell; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Thiazolidinediones; Transcription, Genetic; Tretinoin | 2009 |
Human spongiosa mesenchymal stem cells fail to generate cardiomyocytes in vitro.
Topics: Azacitidine; Cell Differentiation; Coculture Techniques; Culture Media; Humans; Hydroxamic Acids; Mesenchymal Stem Cells; Myocardium | 2009 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Topics: Adenosine; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors | 2009 |
IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Cisplatin; DNA Methylation; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; HeLa Cells; HT29 Cells; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 3; Kaplan-Meier Estimate; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tumor Cells, Cultured | 2010 |
Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines.
Topics: Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Azacitidine; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Drug Antagonism; Drug Synergism; Electrophoresis, Capillary; Growth Inhibitors; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; K562 Cells; Leukemia; Oxides; U937 Cells; Valproic Acid | 2010 |
Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Base Sequence; Blotting, Western; DNA Methylation; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Electrophoresis, Gel, Two-Dimensional; Flow Cytometry; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mitochondrial Proton-Translocating ATPases; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 2010 |
Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cisplatin; Decitabine; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Muscle Proteins; Ovarian Neoplasms; Prognosis; Promoter Regions, Genetic; Proportional Hazards Models; SKP Cullin F-Box Protein Ligases; Smad4 Protein; Taiwan; Transforming Growth Factor beta; Young Adult | 2010 |
Differentiation of human adipose-derived stem cells into beating cardiomyocytes.
Topics: Actins; Adipose Tissue; Adult; Animals; Animals, Newborn; Azacitidine; Calcium; Cell Communication; Cell Differentiation; Cells, Cultured; Coculture Techniques; Culture Media; Gap Junctions; Gene Expression Regulation; Heart; Humans; Hydroxamic Acids; Imaging, Three-Dimensional; Middle Aged; Myocytes, Cardiac; Rats; RNA, Messenger; Stem Cells; Troponin T | 2010 |
Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation.
Topics: Acetylation; Apoptosis; Azacitidine; Butyrates; Cell Line, Tumor; Decitabine; Early Growth Response Protein 1; Gene Knockdown Techniques; Histones; Humans; Hydroxamic Acids; p300-CBP Transcription Factors; Promoter Regions, Genetic; PTEN Phosphohydrolase; Stomach Neoplasms; Up-Regulation; Vitamin D | 2010 |
Decreased fibronectin production significantly contributes to dysregulated repair of asthmatic epithelium.
Topics: Adolescent; Asthma; Azacitidine; Cells, Cultured; Child; Child, Preschool; Cycloheximide; Dexamethasone; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Extracellular Matrix; Fibronectins; Homocystine; Humans; Hydroxamic Acids; Hypersensitivity; Microarray Analysis; Respiratory Mucosa; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta1 | 2010 |
The novel human endogenous retrovirus-related gene, psiTPTE22-HERV, is silenced by DNA methylation in cancers.
Topics: Azacitidine; Blotting, Western; Chromosomes, Human, Pair 22; Cytoplasm; Decitabine; DNA Methylation; DNA Modification Methylases; Endogenous Retroviruses; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Membrane Proteins; Neoplasms; Open Reading Frames; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic | 2010 |
Differential regulation of the dioxin-induced Cyp1a1 and Cyp1b1 genes in mouse hepatoma and fibroblast cell lines.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Azacitidine; Carcinoma, Hepatocellular; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Decitabine; Dioxins; Enzyme Induction; Fibroblasts; Gene Expression Regulation, Enzymologic; Hybrid Cells; Hydroxamic Acids; Liver Neoplasms; Mice; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2010 |
The effect of epigenetic therapy on congenital neurogenic bladders--a pilot study.
Topics: Azacitidine; Cells, Cultured; Collagen; Epigenesis, Genetic; Genetic Therapy; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Muscle, Smooth; Pilot Projects; Urinary Bladder; Urinary Bladder, Neurogenic; Valproic Acid | 2010 |
TWIST1 hypermethylation is observed frequently in colorectal tumors and its overexpression is associated with unfavorable outcomes in patients with colorectal cancer.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Azacitidine; Case-Control Studies; Cell Line, Tumor; Chromosome Mapping; Colorectal Neoplasms; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Intestinal Mucosa; Linear Models; Male; Middle Aged; Nuclear Proteins; Polymerase Chain Reaction; Prognosis; Sequence Analysis, DNA; Statistics, Nonparametric; Twist-Related Protein 1 | 2010 |
Changes in chromatin structure and methylation of the human interleukin-1beta gene during monopoiesis.
Topics: Azacitidine; Calcitriol; Cell Differentiation; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokines; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation, Leukemic; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Interleukin-1beta; Lipopolysaccharide Receptors; Lipopolysaccharides; Micrococcal Nuclease; Monocytes; Myelopoiesis; Promoter Regions, Genetic | 2010 |
Epigenetic regulation affects N-myc downstream-regulated gene 1 expression indirectly in pancreatic cancer cells.
Topics: Azacitidine; Cell Cycle Proteins; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Pancreatic Neoplasms; Promoter Regions, Genetic; Tumor Cells, Cultured | 2010 |
Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells.
Topics: Acetylation; Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Exons; Histones; Hydroxamic Acids; Mice; Nerve Growth Factors; Neurons; Promoter Regions, Genetic | 2010 |
The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice.
Topics: Amputation, Surgical; Animals; Azacitidine; Female; Forelimb; Gene Expression Regulation; Histone Deacetylase Inhibitors; Hydroxamic Acids; Methyltransferases; Mice; Mice, Inbred C57BL; Proliferating Cell Nuclear Antigen; Regeneration; RNA, Messenger; Staining and Labeling; Toes | 2010 |
Methylation of PARP-1 promoter involved in the regulation of benzene-induced decrease of PARP-1 mRNA expression.
Topics: Azacitidine; Benzene; Carcinogens; Cell Line; Decitabine; DNA Methylation; Drug Synergism; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methyltransferases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; RNA, Messenger | 2010 |
[Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and apoptosis of ALDH1a2 gene in human bladder cancer cell lines].
Topics: Aldehyde Dehydrogenase 1 Family; Apoptosis; Azacitidine; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Retinal Dehydrogenase; Urinary Bladder Neoplasms | 2010 |
Promoter hypomethylation contributes to the expression of MUC3A in cancer cells.
Topics: 5' Flanking Region; Azacitidine; Carcinoma; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Mucin-3; RNA, Messenger | 2010 |
Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Apoptosis Regulatory Proteins; Azacitidine; Carcinoma; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Mice; Middle Aged; Nasopharyngeal Neoplasms; Neoplasm Transplantation; Polymerase Chain Reaction; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; RNA, Messenger; Time Factors; Transfection; Tumor Suppressor Proteins; Young Adult | 2010 |
Wnt antagonist DKK1 acts as a tumor suppressor gene that induces apoptosis and inhibits proliferation in human renal cell carcinoma.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Blotting, Western; Carcinoma, Renal Cell; Caspase 3; Cell Proliferation; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Male; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Wnt Proteins | 2011 |
Epigenetically altered wound healing in keloid fibroblasts.
Topics: Acetylation; Azacitidine; Black or African American; Cell Division; Cells, Cultured; Culture Media; Decitabine; Dermis; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Fibrosis; Gene Expression Profiling; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Insulin-Like Growth Factor Binding Protein 5; Intercellular Signaling Peptides and Proteins; Keloid; Membrane Proteins; Oligonucleotide Array Sequence Analysis; Wound Healing | 2010 |
Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors.
Topics: Azacitidine; Cell Line, Tumor; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Multiple Myeloma; Neoplasm Proteins; ran GTP-Binding Protein; Transcription Factors | 2010 |
S100A6 overexpression is associated with poor prognosis and is epigenetically up-regulated in gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Female; Humans; Hydroxamic Acids; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Protein Synthesis Inhibitors; S100 Calcium Binding Protein A6; S100 Proteins; Stomach Neoplasms; Up-Regulation | 2010 |
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Topics: Azacitidine; Calcitriol; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Promoter Regions, Genetic; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Steroid Hydroxylases; Vitamin D3 24-Hydroxylase | 2010 |
The functional significance of microRNA-145 in prostate cancer.
Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Decitabine; DNA Methylation; Down-Regulation; Gene Silencing; Genistein; Humans; Hydroxamic Acids; Male; Microarray Analysis; MicroRNAs; Prostatic Neoplasms; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2010 |
Demethylation by 5-aza-2'-deoxycytidine in colorectal cancer cells targets genomic DNA whilst promoter CpG island methylation persists.
Topics: Acetylation; Apoptosis; Azacitidine; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Cells, Cultured; Colorectal Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2010 |
Promoter hypermethylation and histone hypoacetylation contribute to pancreatic-duodenal homeobox 1 silencing in gastric cancer.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Neoplasms; Trans-Activators; Tumor Cells, Cultured | 2010 |
Function and regulatory mechanisms of the candidate tumor suppressor receptor protein tyrosine phosphatase gamma (PTPRG) in breast cancer cells.
Topics: Animals; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; CpG Islands; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Decitabine; DNA Methylation; Extracellular Signal-Regulated MAP Kinases; Female; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Mice; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 5 | 2010 |
Epigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications.
Topics: Acetylation; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Nuclear Proteins; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors | 2010 |
Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent.
Topics: Azacitidine; Cells, Cultured; Decitabine; DNA Modification Methylases; Endometriosis; Endometrium; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methylation; Promoter Regions, Genetic; Receptors, Progesterone; Stromal Cells | 2010 |
Trichostatin A and 5-azacytidine both cause an increase in global histone H4 acetylation and a decrease in global DNA and H3K9 methylation during mitosis in maize.
Topics: Acetylation; Azacitidine; Chromatin; DNA Methylation; Enzyme Inhibitors; Histones; Hydroxamic Acids; Interphase; Mitosis; Zea mays | 2010 |
Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.
Topics: Animals; Antigens, CD34; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Bone Marrow; Cells, Cultured; Chromatin; Decitabine; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; Immunoblotting; Interleukin Receptor Common gamma Subunit; Janus Kinase 2; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Mutation; Primary Myelofibrosis; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vorinostat | 2010 |
Epigenetic silencing of somatostatin in gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Methylation; Predictive Value of Tests; Reproducibility of Results; RNA, Messenger; Somatostatin; Stomach Neoplasms | 2011 |
Chromatin-modifying agents increase transcription of CYP46A1, a key player in brain cholesterol elimination.
Topics: Analysis of Variance; Azacitidine; Blotting, Western; Cholesterol; Cholesterol 24-Hydroxylase; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neurons; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sp1 Transcription Factor; Sp3 Transcription Factor; Steroid Hydroxylases | 2010 |
Cell line-dependent variability in HIV activation employing DNMT inhibitors.
Topics: Azacitidine; Decitabine; DNA Modification Methylases; Enzyme Inhibitors; Genes, Reporter; Green Fluorescent Proteins; HIV; Humans; Hydroxamic Acids; Jurkat Cells; Tumor Necrosis Factor-alpha; Virus Activation; Virus Latency | 2010 |
Epigenetic regulation on the 5'-proximal CpG island of human porcine endogenous retrovirus subgroup A receptor 2/GPR172B.
Topics: Animals; Azacitidine; Cell Culture Techniques; CpG Islands; Decitabine; DNA Methylation; Endogenous Retroviruses; Epigenomics; Gene Expression Regulation, Viral; HEK293 Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Receptors, Virus; Swine | 2011 |
Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Azacitidine; Bone Marrow Cells; Bone Regeneration; Cell Differentiation; Cell Lineage; Cells, Cultured; Chondrogenesis; Core Binding Factor Alpha 1 Subunit; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Osteogenesis; Stromal Cells | 2011 |
Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation.
Topics: Adenine Phosphoribosyltransferase; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2011 |
Epigenetic modification involved in benzene-induced apoptosis through regulating apoptosis-related genes expression.
Topics: Animals; Apoptosis; Azacitidine; Benzene; Bone Marrow Cells; Carcinogens; Cells, Cultured; Epigenesis, Genetic; Gene Expression Regulation; Hydroxamic Acids; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2011 |
Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A.
Topics: Animals; Azacitidine; Blastocyst; Cattle; Cloning, Organism; Decitabine; Embryo Transfer; Embryonic Development; Female; Hydroxamic Acids; Nuclear Transfer Techniques; Pregnancy; Pregnancy Outcome | 2011 |
Modulation of matrix metalloproteinase activity in human thyroid cancer cell lines using demethylating agents and histone deacetylase inhibitors.
Topics: Adenocarcinoma, Follicular; Adenocarcinoma, Papillary; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Drug Screening Assays, Antitumor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Thyroid Neoplasms; Valproic Acid | 2011 |
(-)-Epigallocatechin-3-gallate reactivates silenced tumor suppressor genes, Cip1/p21 and p16INK4a, by reducing DNA methylation and increasing histones acetylation in human skin cancer cells.
Topics: Acetylation; Anticarcinogenic Agents; Azacitidine; Catechin; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Genes, p16; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Skin Neoplasms; Transcriptional Activation | 2011 |
Epigenetic repression of SATB1 by polycomb group protein EZH2 in epithelial cells.
Topics: Azacitidine; Base Sequence; Cell Line; Chromatin Immunoprecipitation; DNA Methylation; DNA Primers; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelium; Gene Silencing; Humans; Hydroxamic Acids; Matrix Attachment Region Binding Proteins; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2010 |
Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Decitabine; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Humans; Hydroxamic Acids; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Paclitaxel; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA Interference; Transplantation, Heterologous | 2011 |
Aberrant methylation frequency of TNFRSF10C promoter in pancreatic cancer cell lines.
Topics: Apoptosis; Azacitidine; Decitabine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Gene Expression; GPI-Linked Proteins; Humans; Hydroxamic Acids; Pancreatic Neoplasms; Promoter Regions, Genetic; Receptors, Tumor Necrosis Factor, Member 10c; Restriction Mapping; Sequence Analysis, DNA; Tumor Cells, Cultured; Tumor Necrosis Factor Decoy Receptors | 2011 |
Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Azacitidine; Carbonic Anhydrase IX; Carbonic Anhydrases; Cell Hypoxia; Cell Line, Tumor; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Promoter Regions, Genetic; Stomach Neoplasms | 2011 |
Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis.
Topics: Adenocarcinoma; Adenoma; Antineoplastic Agents, Alkylating; Azacitidine; Caco-2 Cells; Cell Survival; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Gene Expression; Gene Silencing; Humans; Hydroxamic Acids; Receptors, Calcium-Sensing; RNA, Messenger; Tissue Array Analysis | 2011 |
Histone deacetylase inhibitors upregulate Rap1GAP and inhibit Rap activity in thyroid tumor cells.
Topics: Adenocarcinoma, Follicular; Azacitidine; Butyrates; Carcinoma; Carcinoma, Papillary; Cell Line, Tumor; Decitabine; DNA Methylation; Drug Screening Assays, Antitumor; Drug Synergism; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasm Proteins; rap GTP-Binding Proteins; rap1 GTP-Binding Proteins; RNA, Small Interfering; Thyroid Neoplasms; Up-Regulation | 2011 |
DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Azacitidine; Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Decitabine; DNA Methylation; Early Growth Response Protein 1; Gene Expression Regulation, Neoplastic; Gene Silencing; Glioblastoma; Growth Differentiation Factor 15; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Sulindac; Transfection | 2012 |
[Study of RASSF1A expression and promoter demethylation in Hep-2 cell line].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; DNA Methylation; Gene Expression; Gene Silencing; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2011 |
The effects of 5-aza-2'- deoxycytidine and trichostatin A on gene expression and DNA methylation status in cloned bovine blastocysts.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Blastocyst; Cattle; Cloning, Organism; Decitabine; DNA Methylation; Female; Fertilization in Vitro; Gene Expression; Histone Deacetylase Inhibitors; Hydroxamic Acids; Nuclear Transfer Techniques | 2011 |
Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Silencing; Hydroxamic Acids; Mammary Glands, Animal; Mammary Neoplasms, Animal; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 2011 |
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Azacitidine; Cell Division; Cell Line, Tumor; Cell Proliferation; Decitabine; Drug Synergism; Drug Therapy, Combination; Epigenomics; Female; G2 Phase; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genomic Imprinting; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Transplantation, Heterologous; Vorinostat | 2011 |
Effect of trichostatin A and 5-Aza-2'-deoxycytidine on transgene reactivation and epigenetic modification in transgenic pig fibroblast cells.
Topics: Acetylation; Animals; Animals, Genetically Modified; Azacitidine; Cell Shape; Cell Survival; Cells, Cultured; Cytomegalovirus; Decitabine; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Gene Expression Regulation; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Methyltransferases; Promoter Regions, Genetic; Swine; Transgenes | 2011 |
Cardiomyocyte marker expression in a human lymphocyte cell line using mouse cardiomyocyte extract.
Topics: Actins; Animals; Azacitidine; B-Lymphocytes; Biomarkers; Cell Extracts; Cell Membrane Permeability; Cell Transdifferentiation; Decitabine; Flow Cytometry; Humans; Hydroxamic Acids; Immunohistochemistry; Mice; Myocytes, Cardiac; Myosin Heavy Chains; Troponin T | 2011 |
Epigenetic inactivation of the SFRP1 gene in esophageal squamous cell carcinoma.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; DNA Methylation; Esophageal Neoplasms; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Membrane Proteins | 2011 |
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cell Line, Tumor; Chromatin Immunoprecipitation; Cohort Studies; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Lung Neoplasms; Male; Matrix Attachment Region Binding Proteins; Middle Aged; Neoplasm Staging; Prognosis; Tissue Array Analysis | 2011 |
Effects of epigenetic-based anti-cancer drugs in leukaemia and multiple myeloma cells.
Topics: Antineoplastic Agents; Azacitidine; Chromobox Protein Homolog 5; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Leukemia; Multiple Myeloma; Retinoblastoma Protein; Tumor Suppressor Protein p53 | 2011 |
SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; DNA Modification Methylases; DNA Mutational Analysis; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Liver Neoplasms; Male; Middle Aged; Molecular Sequence Data; Promoter Regions, Genetic; Repressor Proteins; Restriction Mapping; Transcription, Genetic; Young Adult; Zinc Finger E-box Binding Homeobox 2 | 2011 |
Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter.
Topics: Azacitidine; Binding Sites; CCCTC-Binding Factor; Cell Line, Tumor; Decitabine; DNA Methylation; DNA, Neoplasm; Down-Regulation; Genes, Reporter; Genes, Retinoblastoma; Glioma; HeLa Cells; Humans; Hydroxamic Acids; K562 Cells; Mutation; Nucleic Acid Conformation; Promoter Regions, Genetic; Repressor Proteins; Sequence Analysis, DNA; Transgenes | 2011 |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Endothelial Cells; Epithelial-Mesenchymal Transition; Heparitin Sulfate; Histones; Humans; Hydroxamic Acids; Methylation; Pancreatic Neoplasms; RNA, Messenger; Sequence Analysis, DNA; Snail Family Transcription Factors; Sulfotransferases; Transcription Factors; Transcriptional Activation | 2011 |
Aberrant DNA methylation but not mutation of CITED4 is associated with alteration of HIF-regulated genes in breast cancer.
Topics: Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Glucose Transporter Type 1; HCT116 Cells; HL-60 Cells; Humans; Hydroxamic Acids; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; K562 Cells; Mutation; Neoplasm Invasiveness; Polymorphism, Genetic; Promoter Regions, Genetic; RNA, Messenger; Transcription Factors | 2011 |
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: roles of epigenetic modifications in transcriptional regulation.
Topics: 5' Flanking Region; Animals; Azacitidine; Cell Line; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Genome; Histones; Humans; Hydroxamic Acids; Mice; Organ Specificity; Promoter Regions, Genetic; Protein Processing, Post-Translational; Rats; Receptors, Ghrelin; RNA, Messenger; Transcription Initiation Site; Transcription, Genetic | 2011 |
Methylation of specific CpG sites in the P2 promoter of parathyroid hormone-related protein determines the invasive potential of breast cancer cell lines.
Topics: 5' Flanking Region; Azacitidine; Breast Neoplasms; Cells, Cultured; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Parathyroid Hormone-Related Protein; Promoter Regions, Genetic | 2011 |
Genomic DNA hypomethylation by histone deacetylase inhibition implicates DNMT1 nuclear dynamics.
Topics: Azacitidine; Cell Line, Tumor; Cell Nucleus; Chromatin; Cyclin-Dependent Kinase Inhibitor p21; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Protein Isoforms | 2011 |
Improvement of cardiac function in mouse myocardial infarction after transplantation of epigenetically-modified bone marrow progenitor cells.
Topics: Animals; Azacitidine; Bone Marrow Cells; Cell Differentiation; Decitabine; Endothelial Cells; Epigenesis, Genetic; Gene Expression Regulation; Heart; Hydroxamic Acids; Inflammation; Male; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Neovascularization, Physiologic; Pluripotent Stem Cells; Stem Cell Transplantation; Stem Cells; Ventricular Dysfunction, Left | 2011 |
γ-radiation induces cellular sensitivity and aberrant methylation in human tumor cell lines.
Topics: Ataxia Telangiectasia Mutated Proteins; Azacitidine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Decitabine; DNA Breaks; DNA Methylation; DNA-Binding Proteins; Gamma Rays; Genes, p16; Humans; Hydroxamic Acids; Neoplasms; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Radiation Tolerance; Tumor Suppressor Proteins | 2011 |
TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Cadherins; Carcinoma, Renal Cell; Case-Control Studies; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Male; Middle Aged; Promoter Regions, Genetic; Prostatic Neoplasms; ROC Curve; Sensitivity and Specificity; Urinary Bladder Neoplasms | 2011 |
Dynamics of bivalent chromatin domains upon drug induced reactivation and resilencing in cancer cells.
Topics: Azacitidine; Chromatin; Chromosomes, Human, Pair 2; Chromosomes, Human, Pair 3; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Histones; Humans; Hydroxamic Acids; Inhibin-beta Subunits; Jumonji Domain-Containing Histone Demethylases; Time Factors; Transcriptional Activation | 2011 |
Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia.
Topics: Aged; Antigens, Neoplasm; Antimetabolites, Antineoplastic; Azacitidine; Biomarkers; Bone Marrow Cells; Case-Control Studies; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenomics; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunotherapy; Leukemia, Myeloid, Acute; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2011 |
Trichostatin a promotes cardiomyocyte differentiation of rat mesenchymal stem cells after 5-azacytidine induction or during coculture with neonatal cardiomyocytes via a mechanism independent of histone deacetylase inhibition.
Topics: Animals; Animals, Newborn; Azacitidine; Cell Differentiation; Cells, Cultured; Coculture Techniques; GATA4 Transcription Factor; Histone Deacetylase Inhibitors; Histone Deacetylases; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Hydroxamic Acids; MEF2 Transcription Factors; Mesenchymal Stem Cells; Myocytes, Cardiac; Myogenic Regulatory Factors; Rats; Rats, Wistar; Time Factors; Transcription Factors; Troponin T | 2012 |
Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Down-Regulation; Epigenomics; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MicroRNAs; Polymerase Chain Reaction; RNA, Neoplasm; Stomach Neoplasms | 2011 |
Epigenetic modifiers exert renal toxicity through induction of p66shc.
Topics: Animals; Azacitidine; Binding Sites; Cell Line, Transformed; Cytochromes c; Epigenesis, Genetic; Gene Knockdown Techniques; Hydroxamic Acids; Kidney Tubules, Proximal; Mice; Mitochondria; Mutation; Promoter Regions, Genetic; Protein Binding; Reactive Oxygen Species; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Up-Regulation | 2011 |
Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline.
Topics: Acetylation; Azacitidine; Catalase; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Down-Regulation; Doxorubicin; Drug Resistance; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Protein Modification, Translational | 2012 |
CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells.
Topics: Acetylation; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Epigenesis, Genetic; Flow Cytometry; Gene Expression Profiling; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Interferon-gamma; Nuclear Proteins; Promoter Regions, Genetic; Rhabdomyosarcoma; Signal Transduction; Trans-Activators | 2012 |
Heparanase expression is associated with histone modifications in glioblastoma.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; CpG Islands; Decitabine; DNA Modification Methylases; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioblastoma; Glucuronidase; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Molecular Sequence Data; NF-kappa B p50 Subunit; Promoter Regions, Genetic; Protein Processing, Post-Translational; Transcription Factor RelA | 2012 |
[Silence mechanism of WT1 gene in leukemic cell line U937].
Topics: Azacitidine; Decitabine; DNA Methylation; Gene Silencing; Histones; HL-60 Cells; Humans; Hydroxamic Acids; K562 Cells; Promoter Regions, Genetic; U937 Cells; WT1 Proteins | 2011 |
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromosomes, Human, Pair 3; Decitabine; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Lysine; Multigene Family; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2011 |
RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Blotting, Western; Caspase 3; Cell Line, Tumor; Cell Proliferation; Core Binding Factor Alpha 3 Subunit; CpG Islands; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2012 |
Epigenetic modulation of the HeLa cell membrane N-glycome.
Topics: Antineoplastic Agents; Azacitidine; Butyrates; Carbohydrate Sequence; Cytidine; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glycomics; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Molecular Sequence Data; Polysaccharides | 2012 |
Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; Epigenesis, Genetic; Humans; Hydroxamic Acids; Jurkat Cells; Neuroblastoma; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; T-Lymphocytes | 2012 |
Protocadherin8 is a functional tumor suppressor frequently inactivated by promoter methylation in nasopharyngeal carcinoma.
Topics: Apoptosis; Azacitidine; Cadherins; Cell Adhesion; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Male; Middle Aged; Nasopharyngeal Neoplasms; Prognosis; Promoter Regions, Genetic; Protocadherins; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wound Healing | 2012 |
Genome-wide miRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers.
Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Profiling; Gene Silencing; Humans; Hydroxamic Acids; Lung; Lung Neoplasms; Male; MicroRNAs; Middle Aged; Molecular Targeted Therapy; Oligonucleotide Array Sequence Analysis | 2012 |
Methylation characteristics and developmental potential of Guangxi Bama minipig (Sus scrofa domestica) cloned embryos from donor cells treated with trichostatin A and 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blastocyst; Cell Cycle; Cells, Cultured; Cloning, Organism; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Hydroxamic Acids; Insulin-Like Growth Factor II; Kidney; Nuclear Transfer Techniques; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Swine, Miniature | 2013 |
Position effect variegation and epigenetic modification of a transgene in a pig model.
Topics: Animals; Animals, Genetically Modified; Azacitidine; Cell Line; Chromatin Assembly and Disassembly; Chromosomal Position Effects; Cytomegalovirus; Decitabine; DNA Methylation; Enzyme Inhibitors; Genetic Variation; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Promoter Regions, Genetic; Swine; Transgenes | 2012 |
Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia.
Topics: Apoptosis Regulatory Proteins; Azacitidine; Cell Division; Cell Line, Tumor; CpG Islands; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Neoplasm; Female; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Genes, Immunoglobulin; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Immunoglobulin Heavy Chains; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Male; Neoplasm Proteins; Sequence Analysis, DNA; Transcription Factors | 2012 |
Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines.
Topics: Azacitidine; Cell Line, Tumor; Colonic Neoplasms; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Membrane Transport Proteins; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Molecular analysis of FMR1 reactivation in fragile-X induced pluripotent stem cells and their neuronal derivatives.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Differentiation; Cells, Cultured; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Fragile X Mental Retardation Protein; Fragile X Syndrome; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Induced Pluripotent Stem Cells; Mice; Neurons | 2012 |
Epigenetic modification of TLRs in leukocytes is associated with increased susceptibility to Salmonella enteritidis in chickens.
Topics: Animals; Avian Proteins; Azacitidine; Bacterial Load; Base Sequence; Chickens; Cytokines; Decitabine; DNA Primers; Epigenesis, Genetic; Genetic Predisposition to Disease; Hydroxamic Acids; Leukocytes; Poultry Diseases; Salmonella enteritidis; Salmonella Infections, Animal; Toll-Like Receptors | 2012 |
Activation and epigenetic regulation of DNA transposon nDart1 in rice.
Topics: Azacitidine; DNA Methylation; DNA Transposable Elements; DNA, Plant; Epigenesis, Genetic; Gene Expression Regulation, Plant; Genes, Plant; Hydroxamic Acids; Mutation; Oryza; Seeds; Sequence Analysis, DNA; Transposases | 2012 |
Silencing of Wnt5a during colon cancer metastasis involves histone modifications.
Topics: Azacitidine; Cell Line, Tumor; Colonic Neoplasms; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Neoplasm Metastasis; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Wnt Proteins; Wnt-5a Protein | 2012 |
Even-skipped homeobox 1 is frequently hypermethylated in prostate cancer and predicts PSA recurrence.
Topics: Azacitidine; Cell Line, Tumor; Disease-Free Survival; DNA Methylation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Male; Prognosis; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms; Recurrence | 2012 |
DNMT1: an emerging target in the treatment of invasive urinary bladder cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Immunohistochemistry; Oligonucleotide Array Sequence Analysis; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Transcriptome; Urinary Bladder Neoplasms | 2013 |
Towards experimental manipulation of stochasticity in gene expression.
Topics: Animals; Azacitidine; Cell Line; Chickens; Chromatin; Gene Expression Regulation; Hydroxamic Acids; Spectrometry, Fluorescence; Stochastic Processes | 2012 |
Expression pattern of SVEP1 alternatively-spliced forms.
Topics: Alternative Splicing; Animals; Antimetabolites, Antineoplastic; Azacitidine; Calcium-Binding Proteins; Cell Adhesion Molecules; Cell Line, Tumor; Coculture Techniques; Estrogens; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Proteins; Rats; Transcription Factors; Tumor Necrosis Factor-alpha | 2012 |
Pharmacological unmasking microarray approach-based discovery of novel DNA methylation markers for hepatocellular carcinoma.
Topics: Azacitidine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Female; Hep G2 Cells; Humans; Hydroxamic Acids; Liver; Liver Neoplasms; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Survival Analysis | 2012 |
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Base Sequence; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Modification Methylases; DNA Primers; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Luciferases; Microarray Analysis; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Tumor Suppressor Proteins | 2012 |
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma.
Topics: Azacitidine; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Latent TGF-beta Binding Proteins; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neovascularization, Pathologic; Promoter Regions, Genetic; Tumor Microenvironment; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor A | 2012 |
Effect of phenylhexyl isothiocyanate on aberrant histone H3 methylation in primary human acute leukemia.
Topics: Acetylation; Acute Disease; Adolescent; Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Case-Control Studies; Child; Decitabine; DNA Methylation; Female; Histone Deacetylase Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Isothiocyanates; Leukemia; Male; Middle Aged; Protein Processing, Post-Translational; Young Adult | 2012 |
Prostaglandin E2 induces growth inhibition, apoptosis and differentiation in T and B cell-derived acute lymphoblastic leukemia cell lines (CCRF-CEM and Nalm-6).
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Caspase 3; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Dinoprostone; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Hydroxamic Acids; Inhibitory Concentration 50; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Up-regulation of miR-182 expression after epigenetic modulation of human melanoma cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Melanoma; MicroRNAs; Oligonucleotide Array Sequence Analysis; Skin; Skin Neoplasms; Up-Regulation | 2013 |
Targeting the MAGE A3 antigen in pancreatic cancer.
Topics: Adenocarcinoma; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokines; Decitabine; Deoxycytidine; DNA Methylation; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Male; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Receptors, Antigen, T-Cell; T-Lymphocytes; Testis; Valproic Acid | 2012 |
[Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and methylation of CHFR in human laryngreal carcinoma cell line].
Topics: Azacitidine; Cell Cycle Proteins; Decitabine; DNA Methylation; Gene Expression; Hep G2 Cells; Humans; Hydroxamic Acids; Laryngeal Neoplasms; Methylation; Neoplasm Proteins; Poly-ADP-Ribose Binding Proteins; Promoter Regions, Genetic; Ubiquitin-Protein Ligases | 2012 |
The TCF4/β-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Breast Neoplasms; Carbohydrate Epimerases; Chromatin; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Promoter Regions, Genetic; Protein Processing, Post-Translational; Transcription Factor 4; Transcription Factors; Transcription, Genetic; Wnt Signaling Pathway | 2012 |
Expression and functions of μ-opioid receptors and cannabinoid receptors type 1 in T lymphocytes.
Topics: Analgesics, Opioid; Animals; Azacitidine; Cannabinoids; Cyclic AMP; Decitabine; Humans; Hydroxamic Acids; Interleukin-2; Interleukin-4; Jurkat Cells; Lymphocyte Activation; Mice; Neuroimmunomodulation; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Signal Transduction; T-Lymphocytes | 2012 |
Enforced expression of RASAL1 suppresses cell proliferation and the transformation ability of gastric cancer cells.
Topics: Aged; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Epstein-Barr Virus Infections; Female; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Helicobacter Infections; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; ras GTPase-Activating Proteins; Stomach Neoplasms | 2012 |
Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype.
Topics: Azacitidine; B-Lymphocytes; Cell Line, Tumor; Cluster Analysis; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Hydroxamic Acids; Inhibitor of Differentiation Protein 2; Lymphoma, Large-Cell, Anaplastic; Phenotype; Promoter Regions, Genetic; T-Lymphocytes; Transcription Factors | 2013 |
Decreased PADI4 mRNA association with global hypomethylation in hepatocellular carcinoma during HBV exposure.
Topics: Adult; Aged; Azacitidine; Carcinoma, Hepatocellular; Cell Line, Tumor; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Histone Deacetylase Inhibitors; Host-Pathogen Interactions; Humans; Hydrolases; Hydroxamic Acids; Immunohistochemistry; Liver Neoplasms; Long Interspersed Nucleotide Elements; Male; Middle Aged; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Analysis | 2013 |
Epigenetic mechanisms regulate the prostaglandin E receptor 2 in breast cancer.
Topics: Adipose Tissue; Azacitidine; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Receptors, Prostaglandin E, EP2 Subtype; Reference Values; Stromal Cells | 2012 |
Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.
Topics: Animals; Azacitidine; Cell Line, Tumor; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Humans; Hydroxamic Acids; Karyotyping; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Phenotype; Risk; Skin Neoplasms | 2012 |
DNA methylation of NDRG2 in gastric cancer and its clinical significance.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Cell Line, Tumor; DNA Methylation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Stomach Neoplasms; Transfection; Tumor Suppressor Proteins | 2013 |
Sulforaphane causes a major epigenetic repression of myostatin in porcine satellite cells.
Topics: 3' Untranslated Regions; Animals; Azacitidine; Base Sequence; Cells, Cultured; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Follistatin; Gene Expression Regulation; Histone Deacetylase Inhibitors; Hydroxamic Acids; Isothiocyanates; MicroRNAs; Molecular Sequence Data; MyoD Protein; Myostatin; Promoter Regions, Genetic; Satellite Cells, Skeletal Muscle; Signal Transduction; Sulfoxides; Swine; Thiocyanates | 2012 |
Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Embryonal; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Embryonal Carcinoma Stem Cells; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Genes, Reporter; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Luciferases; MCF-7 Cells; Neoplasm Invasiveness; Neoplasm Proteins; Nuclear Receptor Subfamily 6, Group A, Member 1; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; RNA Interference; RNA, Messenger; Time Factors; Tissue Array Analysis; Transcription, Genetic; Transfection; Tretinoin; Valproic Acid | 2013 |
Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2.
Topics: Azacitidine; Base Sequence; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA Modification Methylases; Down-Regulation; Focal Adhesion Kinase 2; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Liver Neoplasms; MicroRNAs; Multigene Family; Oligonucleotide Array Sequence Analysis; RNA Interference; Transcriptome | 2013 |
Oxidative stress in coronary artery disease: epigenetic perspective.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line; Coronary Artery Disease; Decitabine; DNA Methylation; Endothelial Cells; Epigenesis, Genetic; Female; Ferredoxin-NADP Reductase; Folic Acid; Glutathione S-Transferase pi; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Hydroxamic Acids; Male; Malondialdehyde; Membrane Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidative Stress; Promoter Regions, Genetic; Protein Carbonylation; Proto-Oncogene Proteins; Superoxide Dismutase; Young Adult | 2013 |
5-aza-2'-deoxycytidine has minor effects on differentiation in human thyroid cancer cell lines, but modulates genes that are involved in adaptation in vitro.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Carcinoma; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Survival; Decitabine; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Oligonucleotide Array Sequence Analysis; Thyroid Gland; Thyroid Neoplasms; Vorinostat | 2013 |
Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
Topics: Animals; Anterior Chamber; Antimetabolites, Antineoplastic; Azacitidine; Cecum; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Injections; Injections, Subcutaneous; Lysine; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Up-Regulation | 2013 |
Evaluation of long-term transgene expression in piggyBac-modified human T lymphocytes.
Topics: Antineoplastic Agents; Azacitidine; Cells, Cultured; Cytokines; DNA Transposable Elements; Gene Expression; Green Fluorescent Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Leukocytes, Mononuclear; Nerve Tissue Proteins; Receptors, Antigen, T-Cell; T-Lymphocytes; Transfection; Transgenes | 2013 |
MiR-383 is downregulated in medulloblastoma and targets peroxiredoxin 3 (PRDX3).
Topics: Adolescent; Adult; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Child; Child, Preschool; Decitabine; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Male; Medulloblastoma; MicroRNAs; Peroxiredoxin III; RNA Interference; Young Adult | 2013 |
MIR-137 suppresses growth and invasion, is downregulated in oligodendroglial tumors and targets CSE1L.
Topics: Adult; Aged; Azacitidine; Brain Neoplasms; Bromodeoxyuridine; Cell Line, Tumor; Cell Proliferation; Cellular Apoptosis Susceptibility Protein; Child; Cohort Studies; Collagen; Decitabine; Down-Regulation; Drug Combinations; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Laminin; Male; MicroRNAs; Middle Aged; Oligodendroglioma; Proteoglycans | 2013 |
Epigenetic marking and repression of porcine endogenous retroviruses.
Topics: Animals; Azacitidine; Cell Line; Decitabine; DNA Methylation; DNA, Viral; Down-Regulation; Endogenous Retroviruses; Enzyme Inhibitors; Epigenetic Repression; Gene Expression Regulation, Viral; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Male; Mice; Primary Cell Culture; Proviruses; RNA, Messenger; RNA, Viral; Swine; Swine Diseases; Swine, Miniature; Up-Regulation | 2013 |
Epigenetic inactivation of ADAMTS9 via promoter methylation in multiple myeloma.
Topics: ADAM Proteins; ADAMTS9 Protein; Adult; Aged; Azacitidine; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Female; Humans; Hydroxamic Acids; Male; Middle Aged; Multiple Myeloma; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints | 2013 |
Anticancer efficacy of cisplatin and trichostatin A or 5-aza-2'-deoxycytidine on ovarian cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Blotting, Western; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Decitabine; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Mice, Inbred C3H; Mice, SCID; Ovarian Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured | 2013 |
Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance, Neoplasm; Drug Synergism; Epigenesis, Genetic; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Genistein; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Nude; Mice, Transgenic; Proliferating Cell Nuclear Antigen; Promoter Regions, Genetic; Tamoxifen; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
(Some) cellular mechanisms influencing the transcription of human endogenous retrovirus, HERV-Fc1.
Topics: Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Endogenous Retroviruses; Epigenesis, Genetic; Gene Expression Regulation; Humans; Hydroxamic Acids; Promoter Regions, Genetic; Retroelements; Terminal Repeat Sequences; Transcription, Genetic | 2013 |
Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer.
Topics: Adenocarcinoma; Aged; Azacitidine; Case-Control Studies; Cell Line, Tumor; Conserved Sequence; Decitabine; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Genome, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Metribolone; Middle Aged; Oligonucleotide Array Sequence Analysis; Prostate; Prostatic Neoplasms; RNA, Messenger; RNA, Neoplasm; RNA, Untranslated; Testosterone Congeners; Transcriptome | 2013 |
Silibinin synergizes with histone deacetylase and DNA methyltransferase inhibitors in upregulating E-cadherin expression together with inhibition of migration and invasion of human non-small cell lung cancer cells.
Topics: Antioxidants; Azacitidine; Blotting, Western; Cadherins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Decitabine; Drug Synergism; Enzyme Inhibitors; Epigenesis, Genetic; Gene Silencing; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Silybin; Silymarin; Transcription Factors; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2013 |
The role of DNA methylation and histone acetylation in the regulation of progesterone receptor isoforms expression in human astrocytoma cell lines.
Topics: Acetylation; Astrocytoma; Azacitidine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Neoplasm Grading; Protein Isoforms; Receptors, Progesterone | 2013 |
Epigenetically induced changes in nuclear textural patterns and gelatinase expression in human fibrosarcoma cells.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatin Assembly and Disassembly; Decitabine; Disease Progression; DNA Methylation; Epigenesis, Genetic; Fibrosarcoma; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Image Cytometry; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neoplasm Metastasis; Neoplasm Proteins | 2013 |
Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma.
Topics: Antineoplastic Agents; Azacitidine; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Decitabine; Dexamethasone; Disease Progression; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Hydroxamic Acids; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxidants; Prognosis; Pyrazines; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class A | 2013 |
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Topics: Antigen-Presenting Cells; Antigens, Neoplasm; Azacitidine; B-Lymphocytes; Cancer Vaccines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Transformed; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation, Neoplastic; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon-gamma; Melanoma; Neoplasms; RNA, Messenger; Telomerase; Telomere; Tumor Necrosis Factor-alpha; Valproic Acid; Vorinostat | 2013 |
Inhibition of DNA methyltransferases and histone deacetylases induces astrocytic differentiation of neural progenitors.
Topics: Astrocytes; Azacitidine; Cell Differentiation; DNA; DNA Modification Methylases; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Immunohistochemistry; Neural Stem Cells; Neurogenesis; Neurons | 2013 |
Epigenetic control of endothelin-1 axis affects invasiveness of breast carcinoma cells with bone tropism.
Topics: Azacitidine; Bone Neoplasms; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Cell Movement; Collagen; Dactinomycin; DNA Methylation; Drug Combinations; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Laminin; Mutation; Neoplasm Invasiveness; Peptides, Cyclic; Proteoglycans; Proto-Oncogene Protein c-ets-1; Receptor, Endothelin A; RNA Stability; RNA, Messenger; Transcription, Genetic | 2013 |
Inhibition of DNA methyltransferases, histone deacetylases and lysine-specific demethylase-1 suppresses the tumorigenicity of the ovarian cancer ascites cell line SKOV3.
Topics: Acetylation; Animals; Ascites; Azacitidine; Cadherins; Carcinogenesis; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Demethylases; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C3H; Mice, SCID; Neoplasm Invasiveness; Neoplasm Metastasis; Nuclear Proteins; Ovarian Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured; Twist-Related Protein 1 | 2013 |
Reversal of ER-β silencing by chromatin modifying agents overrides acquired tamoxifen resistance.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents, Hormonal; Apoptosis; Azacitidine; Breast Neoplasms; Cell Survival; Chromatin Assembly and Disassembly; Decitabine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MCF-7 Cells; Tamoxifen; Time Factors; Transfection | 2013 |
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
Topics: Acetylation; Animals; Azacitidine; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation; Gene Knockdown Techniques; Gene Silencing; Histones; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Liver Neoplasms; Membrane Proteins; Promoter Regions, Genetic; Tumor Burden; Viral Core Proteins; Wnt Proteins; Xenograft Model Antitumor Assays | 2014 |
Hypomethylation of the CTGF gene locus is a common feature of paediatric pre-B acute lymphoblastic leukaemia.
Topics: Azacitidine; Cells, Cultured; Child; Connective Tissue Growth Factor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Leukemic; Humans; Hydroxamic Acids; Jurkat Cells; Neoplasm Proteins; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Sequence Analysis, DNA | 2013 |
Cubilin expression is monoallelic and epigenetically augmented via PPARs.
Topics: Albumins; Alleles; Animals; Azacitidine; Base Sequence; Caco-2 Cells; Epigenesis, Genetic; Exons; Gene Expression Regulation; Humans; Hydroxamic Acids; Intestines; Kidney Tubules, Proximal; Low Density Lipoprotein Receptor-Related Protein-2; Male; Membrane Proteins; Mice; Peroxisome Proliferator-Activated Receptors; Promoter Regions, Genetic; Protein Transport; Receptors, Cell Surface | 2013 |
Identification of genes specifically methylated in Epstein-Barr virus-associated gastric carcinomas.
Topics: Aged; Azacitidine; Carcinoma; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; DNA Methylation; DNA-Binding Proteins; DNA, Neoplasm; Epstein-Barr Virus Infections; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Homeodomain Proteins; Humans; Hydroxamic Acids; Male; Microfilament Proteins; Middle Aged; Neoplasm Proteins; Nerve Tissue Proteins; Nuclear Proteins; Oncogene Proteins; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Stomach Neoplasms; Transcription Factors; Tumor Protein p73; Tumor Suppressor Proteins | 2013 |
The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer.
Topics: 3' Untranslated Regions; Adult; Aged; Aged, 80 and over; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Decitabine; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Hydroxamic Acids; Male; MicroRNAs; Middle Aged; Neoplasm Staging; ras Proteins; Stomach Neoplasms | 2013 |
Cytostatic and apoptotic effects of DNMT and HDAC inhibitors in endometrial cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Endometrial Neoplasms; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Neoplasm Staging | 2014 |
Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region.
Topics: 5' Untranslated Regions; Acetylation; Azacitidine; Breast Neoplasms; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Loss of Heterozygosity; Promoter Regions, Genetic; RNA, Messenger | 2013 |
Small chemical chromatin effectors alter secondary metabolite production in Aspergillus clavatus.
Topics: Acetylglucosamine; Aspergillus; Azacitidine; Butyrates; Chromatin; Cytochalasins; Histone Deacetylase Inhibitors; Hydroxamic Acids; Methyltransferases; Patulin; Peptones; Pyrrolidinones; Valproic Acid | 2013 |
Suppressed expression of NDRG2 correlates with poor prognosis in pancreatic cancer.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Middle Aged; Negative Staining; Pancreatic Neoplasms; Prognosis; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2013 |
Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development.
Topics: Antineoplastic Agents; Azacitidine; Carcinogenesis; Case-Control Studies; Cystadenoma, Serous; DNA Methylation; DNA, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Hydroxamic Acids; Methyltransferases; Neoplasm Staging; Ovarian Neoplasms; Ovary; rhoB GTP-Binding Protein | 2013 |
Epigenetic repression of the dopamine receptor D4 in pediatric tumors of the central nervous system.
Topics: Apoptosis; Azacitidine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Central Nervous System Neoplasms; Child; Chromatin Assembly and Disassembly; Decitabine; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Humans; Hydroxamic Acids; Male; Medulloblastoma; Neuroectodermal Tumors, Primitive; Receptors, Dopamine D4; Sulfites; Tumor Cells, Cultured | 2014 |
Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts.
Topics: Acetylation; Animals; Azacitidine; Cattle; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Fibroblasts; Gene Expression Regulation; Hydroxamic Acids; Immunity, Innate; Interleukins; Lipopolysaccharides; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; RNA; Serum Amyloid A Protein; Tumor Necrosis Factor-alpha | 2014 |
Expressions of MAGE-A9 and MAGE-A11 in breast cancer and their expression mechanism.
Topics: Adult; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Middle Aged; Neoplasm Proteins; Receptors, Estrogen | 2014 |
Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.
Topics: Animals; Antigens, CD34; Azacitidine; Cell Proliferation; Cells, Cultured; Decitabine; DNA Methylation; Epigenesis, Genetic; Fetal Blood; Gene Expression; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Mice, Inbred NOD; Mice, SCID; Thy-1 Antigens; Transplantation, Heterologous; Valproic Acid | 2014 |
DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer.
Topics: Aged; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Guanine Nucleotide Exchange Factors; Humans; Hydroxamic Acids; Male; MicroRNAs; Middle Aged; Real-Time Polymerase Chain Reaction; Stomach Neoplasms; T-Lymphoma Invasion and Metastasis-inducing Protein 1 | 2015 |
Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact.
Topics: Action Potentials; Animals; Apoptosis; Astacoidea; Azacitidine; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Hydroxamic Acids; In Vitro Techniques; Indoles; Lasers; Mechanoreceptors; Necrosis; Neuroglia; Organometallic Compounds; Photic Stimulation; Photosensitizing Agents; Valproic Acid | 2014 |
Secreted phospholipases A₂are differentially expressed and epigenetically silenced in human breast cancer cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; Group III Phospholipases A2; Group X Phospholipases A2; Humans; Hydroxamic Acids; MCF-7 Cells; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; COUP Transcription Factor II; CpG Islands; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Humans; Hydroxamic Acids; MCF-7 Cells; Real-Time Polymerase Chain Reaction | 2014 |
Chromatin composition alterations and the critical role of MeCP2 for epigenetic silencing of progesterone receptor-B gene in endometrial cancers.
Topics: Adenocarcinoma; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; DNA-Binding Proteins; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Methyl-CpG-Binding Protein 2; Neoplasm Proteins; Protein Binding; Protein Interaction Mapping; Real-Time Polymerase Chain Reaction; Receptors, Progesterone; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Transcription Factors | 2014 |
An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.
Topics: Azacitidine; Epigenesis, Genetic; Gene Expression Regulation, Viral; HEK293 Cells; HIV Infections; HIV-1; Humans; Hydroxamic Acids; Jurkat Cells; Promoter Regions, Genetic; RNA, Antisense; RNA, Long Noncoding; RNA, Messenger; RNA, Viral | 2014 |
The epigenetically regulated effects of Wnt antagonists on the expression of genes in the apoptosis pathway in human bladder cancer cell line (T24).
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; beta Catenin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin D; Cytidine Triphosphate; Dose-Response Relationship, Drug; Epigenomics; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Hydroxamic Acids; Urinary Bladder Neoplasms; Wnt Proteins | 2014 |
Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI.
Topics: Apoptosis; Azacitidine; Breast Neoplasms; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Checkpoint Kinase 1; Cyclin B1; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Decitabine; Female; G2 Phase Cell Cycle Checkpoints; Genetic Vectors; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methyltransferases; Protein Kinases; rho GTP-Binding Proteins; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Transfection; Tumor Suppressor Protein p53 | 2014 |
PTEN methylation involved in benzene-induced hematotoxicity.
Topics: Animals; Azacitidine; Benzene; Body Weight; Carcinogens; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Genes, Tumor Suppressor; Hydroxamic Acids; Leukocytes; Male; Promoter Regions, Genetic; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2014 |
microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle Proteins; Chromosomes, Human, Pair 11; Cohort Studies; Female; Gene Deletion; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Methylation; MicroRNAs; Middle Aged; Promoter Regions, Genetic | 2014 |
Integrated analysis of DNA methylation and mRNA expression profiling reveals candidate genes associated with cisplatin resistance in non-small cell lung cancer.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Azacitidine; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; GPI-Linked Proteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; RNA, Messenger | 2014 |
Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation.
Topics: Azacitidine; Cell Differentiation; Chromatin Assembly and Disassembly; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation; Histone Deacetylase Inhibitors; HL-60 Cells; Humans; Hydroxamic Acids; Inflammation Mediators; Interleukin-6; Lipopolysaccharides; Monocytes; Promoter Regions, Genetic | 2014 |
Effect of 5-aza-2'-deoxycytidine combined with trichostatin A on RPMI-8226 cell proliferation, apoptosis and DLC-1 gene expression.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; Decitabine; Gene Expression; GTPase-Activating Proteins; Humans; Hydroxamic Acids; Multiple Myeloma; Tumor Suppressor Proteins | 2014 |
Aberrant methylation and decreased expression of the TGF-β/Smad target gene FBXO32 in esophageal squamous cell carcinoma.
Topics: Adult; Aged; Azacitidine; Calmodulin-Binding Proteins; Carcinoma, Squamous Cell; Cell Growth Processes; Decitabine; DNA Methylation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Gene Silencing; Humans; Hydroxamic Acids; Immunohistochemistry; Male; Middle Aged; Muscle Proteins; Promoter Regions, Genetic; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Smad Proteins; Transforming Growth Factor beta; Up-Regulation | 2014 |
The effect of chemotherapeutic agents on telomere length maintenance in breast cancer cell lines.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; DNA; DNA Methylation; Epigenesis, Genetic; Female; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Methyltransferases; Promoter Regions, Genetic; Shelterin Complex; Telomere; Telomere Homeostasis; Telomere-Binding Proteins | 2014 |
Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury.
Topics: Acetylation; Acute Lung Injury; Animals; Azacitidine; Blotting, Western; Capillary Permeability; Cell Proliferation; Cell Survival; Chromatin Immunoprecipitation; Decitabine; Disease Models, Animal; Drug Therapy, Combination; Endothelial Cells; Endotoxemia; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Hydroxamic Acids; In Situ Nick-End Labeling; Inflammation; Lung; Male; Methylation; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction | 2014 |
HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methylation; Proteins; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2014 |
An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Case-Control Studies; Cyclin A1; Cyclin D2; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Humans; Hydroxamic Acids; Male; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Predictive Value of Tests; Promoter Regions, Genetic; Urinary Bladder Neoplasms | 2014 |
Epigenetic modification agents improve genomic methylation reprogramming in porcine cloned embryos.
Topics: Animals; Azacitidine; Cellular Reprogramming; Cloning, Organism; Decitabine; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Epigenesis, Genetic; Fertilization in Vitro; Gene Expression; Histone Deacetylase Inhibitors; Hydroxamic Acids; Nuclear Transfer Techniques; Swine | 2014 |
[Expression of neprilysin gene is associated with methylation and histone modification on promoter in mouse neuroblastoma Neuro-2a cells].
Topics: Acetylation; Animals; Azacitidine; Blotting, Western; Cell Line, Tumor; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Mice; Neprilysin; Neuroblastoma; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis.
Topics: Azacitidine; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Female; G2 Phase Cell Cycle Checkpoints; Genes, Tumor Suppressor; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Interferon Regulatory Factors; Kidney Neoplasms; M Phase Cell Cycle Checkpoints; Male; Prognosis; Promoter Regions, Genetic | 2014 |
Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).
Topics: Aryl Hydrocarbon Receptor Nuclear Translocator; Azacitidine; Chromatin; CpG Islands; Cytochrome P-450 CYP1A1; Decitabine; DNA Methylation; Epigenesis, Genetic; HeLa Cells; Hep G2 Cells; Humans; Hydroxamic Acids; Polychlorinated Biphenyls; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; RNA, Messenger | 2014 |
Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes.
Topics: Adipose Tissue, Brown; Animals; Azacitidine; Cell Line, Transformed; Cells, Cultured; DNA Methylation; Embryo, Mammalian; Enzyme Inhibitors; Fibroblasts; Gene Expression; Gene Expression Profiling; Genomic Imprinting; Histone Deacetylase Inhibitors; Hydroxamic Acids; Insulin; Insulin-Like Growth Factor I; Mice, Knockout; MicroRNAs; Oligonucleotide Array Sequence Analysis; Receptor, IGF Type 1; Receptor, Insulin; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2014 |
Effects of 5-aza-2'-deoxycytidine and trichostatin A on high glucose- and interleukin-1β-induced secretory mediators from human retinal endothelial cells and retinal pigment epithelial cells.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Dose-Response Relationship, Drug; Endothelial Cells; Epithelial Cells; Eye Proteins; Gene Expression; Glucose; Humans; Hydroxamic Acids; Intercellular Adhesion Molecule-1; Interleukin-1beta; Matrix Metalloproteinase 2; Nerve Growth Factors; Primary Cell Culture; Retina; Retinal Pigments; RNA, Messenger; Serpins; Vascular Endothelial Growth Factor A | 2014 |
Ex vivo expansion of human mobilized peripheral blood stem cells using epigenetic modifiers.
Topics: Adult; Animals; Antigens, CD34; Azacitidine; Blood Cells; Bone Marrow Cells; Cell Count; Cell Division; Cells, Cultured; Chromatin Assembly and Disassembly; Colony-Forming Units Assay; Cytokines; Decitabine; DNA Methylation; Epigenesis, Genetic; Fetal Blood; Graft Survival; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Heterografts; Humans; Hydroxamic Acids; Immunomagnetic Separation; Infant, Newborn; Mice; Mice, Inbred NOD; Mice, SCID; Peripheral Blood Stem Cell Transplantation; Transcription, Genetic | 2015 |
Identification of epigenetically inactivated genes in human hepatocellular carcinoma by integrative analyses of methylation profiling and pharmacological unmasking.
Topics: Aged; Azacitidine; Biopsy, Needle; Carcinoma, Hepatocellular; Case-Control Studies; Decitabine; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hydroxamic Acids; Liver Neoplasms; Male; Middle Aged; Reference Values; Sampling Studies; Tumor Cells, Cultured | 2014 |
Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status
Topics: Acetylation; Animals; Apoptosis; Azacitidine; Blastocyst; Buffaloes; Cells, Cultured; Cloning, Organism; Decitabine; DNA Methylation; DNA Modification Methylases; Ectogenesis; Embryo Culture Techniques; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; India; Methylation; Protein Processing, Post-Translational | 2016 |
Downregulation of the microRNA-1/133a cluster enhances cancer cell migration and invasion in lung-squamous cell carcinoma via regulation of Coronin1C.
Topics: Aged; Aged, 80 and over; Azacitidine; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Lung Neoplasms; Male; Microfilament Proteins; MicroRNAs; Middle Aged; Multigene Family; Neoplasm Invasiveness; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2015 |
Epigenetic mechanisms are involved in the regulation of ethanol consumption in mice.
Topics: Acetylation; Alcohol Drinking; Animals; Azacitidine; Central Nervous System Depressants; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Ethanol; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Male; Mice, Inbred C57BL; Prefrontal Cortex; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2014 |
RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Alternative Splicing; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cytidine Triphosphate; DNA Methylation; Esophageal Neoplasms; Esophagus; Female; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Humans; Hydroxamic Acids; Male; Middle Aged; Monomeric GTP-Binding Proteins; Neoplasm Invasiveness; Prognosis; Promoter Regions, Genetic; Protein Isoforms; Protein Synthesis Inhibitors; RNA, Messenger, Stored | 2015 |
Methylation of Integrin α4 and E-Cadherin Genes in Human Prostate Cancer.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Biomarkers, Tumor; Cadherins; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Integrin alpha4; Male; Promoter Regions, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2015 |
Prolonged re-expression of the hypermethylated gene EPB41L3 using artificial transcription factors and epigenetic drugs.
Topics: Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Code; Histone Deacetylases; Humans; Hydroxamic Acids; Microfilament Proteins; RNA, Messenger; Transcription Factors | 2015 |
PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas.
Topics: Azacitidine; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Down-Regulation; Enzyme Inhibitors; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Homozygote; Humans; Hydroxamic Acids; Liver Neoplasms; Microarray Analysis; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Receptor-Like Protein Tyrosine Phosphatases, Class 2; Sequence Deletion | 2015 |
Genome-wide differentially methylated genes in prostate cancer tissues from African-American and Caucasian men.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Black or African American; Cell Line, Tumor; Decitabine; DNA Methylation; Gene Expression Regulation, Neoplastic; Genome, Human; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Organ Specificity; Promoter Regions, Genetic; Prostatic Neoplasms; White People | 2015 |
Epigenetics and miRNA as predictive markers and targets for lung cancer chemotherapy.
Topics: Antibiotics, Antineoplastic; Azacitidine; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; Doxorubicin; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lung Neoplasms; MicroRNAs; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs.
Topics: Animals; Azacitidine; Cellular Reprogramming; Cloning, Organism; Decitabine; DNA Methylation; Embryonic Development; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Homeodomain Proteins; Hydroxamic Acids; Sus scrofa; Transcription Factors | 2015 |
Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos.
Topics: Animals; Azacitidine; Cells, Cultured; Cellular Reprogramming; Decitabine; DNA Methylation; Embryo Culture Techniques; Embryonic Development; Enzyme Inhibitors; Epigenesis, Genetic; Fertilization in Vitro; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Hydroxamic Acids; Nuclear Transfer Techniques; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine | 2015 |
Epigenetic modifiers reduce inflammation and modulate macrophage phenotype during endotoxemia-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Azacitidine; Decitabine; Drug Combinations; Endotoxemia; Epigenesis, Genetic; Histone Deacetylases; Humans; Hydroxamic Acids; Inflammation; Lipopolysaccharides; Macrophages; Methyltransferases; Mice; Sepsis; Signal Transduction | 2015 |
Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer.
Topics: Animals; Azacitidine; Benzamidines; Biomarkers, Tumor; Curcumin; Cytochrome P-450 Enzyme System; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Hydroxamic Acids; Molecular Targeted Therapy; Ovarian Neoplasms; Piperazines; Proteins; Retinoid X Receptor gamma | 2015 |
MYCNOS functions as an antisense RNA regulating MYCN.
Topics: Azacitidine; Carrier Proteins; Cell Line, Tumor; DNA Helicases; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Models, Genetic; N-Myc Proto-Oncogene Protein; Neuroblastoma; Nuclear Proteins; Oncogene Proteins; Poly-ADP-Ribose Binding Proteins; Promoter Regions, Genetic; Protein Isoforms; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA Helicases; RNA Recognition Motif Proteins; RNA, Antisense | 2015 |
Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region.
Topics: Animals; Azacitidine; DNA Methylation; Female; Gene Expression Regulation; Genes, Tumor Suppressor; Genetic Loci; Humans; Hydroxamic Acids; Inositol Polyphosphate 5-Phosphatases; Myosin Type I; Phosphoric Monoester Hydrolases; Rats; Tumor Suppressor Protein p53 | 2015 |
Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities.
Topics: Adolescent; Adult; Azacitidine; Cell Culture Techniques; Cell Differentiation; Chromosome Aberrations; Culture Media; Female; Fibroblasts; Humans; Hydroxamic Acids; Induced Pluripotent Stem Cells; Male; Middle Aged; Neural Stem Cells; Schizophrenia; Valproic Acid; Young Adult | 2015 |
Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; Hydroxamic Acids; Immunohistochemistry; Kaplan-Meier Estimate; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; Treatment Outcome; Tumor Suppressor Proteins | 2015 |
Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A.
Topics: Azacitidine; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrogenesis; Drug Therapy, Combination; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mesenchymal Stem Cells; Neurogenesis; Osteogenesis | 2016 |
Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment.
Topics: Acetylation; Aminolevulinic Acid; Azacitidine; Cell Line, Tumor; Cell Movement; Chromatin Immunoprecipitation; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 9; MicroRNAs; Mitochondria; Neoplasm Invasiveness; Photochemotherapy; Promoter Regions, Genetic; Proteins | 2015 |
Differential regulation of expression of RNA-editing enzymes, ADAR1 and ADAR2, by 5-aza-2'-deoxycytidine and trichostatin A in human neuronal SH-SY5Y cells.
Topics: Adenosine Deaminase; Azacitidine; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Neurons; RNA-Binding Proteins; RNA, Messenger | 2015 |
Methylation of tumor suppressor gene CDH13 and SHP1 promoters and their epigenetic regulation by the UHRF1/PRMT5 complex in endometrial carcinoma.
Topics: Azacitidine; Cadherins; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Decitabine; DNA Methylation; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Hydroxamic Acids; Middle Aged; Promoter Regions, Genetic; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein-Arginine N-Methyltransferases; RNA, Messenger; Ubiquitin-Protein Ligases; Up-Regulation | 2016 |
Epigenetic regulation of ZEB1-RAB25/ESRP1 axis plays a critical role in phenylbutyrate treatment-resistant breast cancer.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Decitabine; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Immunohistochemistry; MCF-7 Cells; Phenylbutyrates; rab GTP-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; Signal Transduction; Trastuzumab; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Chickens; Cloning, Molecular; Computational Biology; Decitabine; DNA Methylation; Drug Synergism; Embryonic Stem Cells; Fluorescent Antibody Technique; Gene Expression Regulation; Hydroxamic Acids; Nanog Homeobox Protein; Pluripotent Stem Cells; Promoter Regions, Genetic | 2016 |
Decreased expression of connective tissue growth factor in non-small cell lung cancer is associated with clinicopathological variables and can be restored by epigenetic modifiers.
Topics: Adult; Aged; Aged, 80 and over; Azacitidine; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Connective Tissue Growth Factor; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lung Neoplasms; Male; Middle Aged; Prognosis; Promoter Regions, Genetic; Tumor Cells, Cultured | 2016 |
DNA methylation of claudin-6 promotes breast cancer cell migration and invasion by recruiting MeCP2 and deacetylating H3Ac and H4Ac.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Claudins; DNA Methylation; Epigenesis, Genetic; Female; Histones; Humans; Hydroxamic Acids; MCF-7 Cells; Methyl-CpG-Binding Protein 2; Middle Aged; Neoplasm Invasiveness; Promoter Regions, Genetic; Young Adult | 2016 |
Sex steroid-induced DNA methylation changes and inflammation response in prostate cancer.
Topics: Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Chemokine CXCL5; Chemokines, CC; Cytokines; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Hydroxamic Acids; Inflammation; Interleukin-5; Male; Polymerase Chain Reaction; Promoter Regions, Genetic; Prostatic Neoplasms; Tissue Array Analysis; Tumor Cells, Cultured | 2016 |
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Azacitidine; Cell Line, Tumor; Cell Survival; Decitabine; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Neuroblastoma; Peptide Fragments; RNA, Messenger; Sirtuin 1; Time Factors | 2016 |
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; Azacitidine; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Docetaxel; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Hydroxamic Acids; Kidney; Male; Methylation; Neoplasms; Oligopeptides; Prostatic Neoplasms; Rats; Taxoids | 2016 |
Promoter methylation and histone modifications affect the expression of the exogenous DsRed gene in transgenic goats.
Topics: Animals; Animals, Genetically Modified; Azacitidine; Cytomegalovirus; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Dosage; Gene Expression; Gene Silencing; Goats; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Luminescent Proteins; Male; Promoter Regions, Genetic; Transgenes | 2016 |
Global DNA methylation profiling uncovers distinct methylation patterns of protocadherin alpha4 in metastatic and non-metastatic rhabdomyosarcoma.
Topics: Azacitidine; Biopsy; Cell Adhesion Molecules, Neuronal; Cell Line, Tumor; Cluster Analysis; Cytidine Triphosphate; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome-Wide Association Study; Humans; Hydroxamic Acids; Neoplasm Metastasis; Neuropeptides; Promoter Regions, Genetic; Protocadherins; Receptors, Cell Surface; Rhabdomyosarcoma; Transcriptome | 2016 |
The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.
Topics: Azacitidine; Cell Culture Techniques; Cell Differentiation; Dimethyl Sulfoxide; Drug Evaluation, Preclinical; Epigenesis, Genetic; Hepatocytes; Humans; Hydroxamic Acids; Infant, Newborn; Mesenchymal Stem Cells; Models, Biological; Multidrug Resistance-Associated Protein 2 | 2017 |
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity.
Topics: Acetylation; Animals; Azacitidine; Cell Line; Chemokine CXCL2; Disease Models, Animal; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Hydroxamic Acids; Inflammation; Lipopolysaccharides; Lysophospholipids; Methyltransferases; Mice, Inbred C57BL; Microglia; Promoter Regions, Genetic; Receptors, G-Protein-Coupled; RGS Proteins; RNA, Messenger; Signal Transduction; Sphingosine; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2017 |
Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells.
Topics: A549 Cells; Adenocarcinoma; Adenocarcinoma of Lung; Azacitidine; Butyric Acid; Cell Proliferation; Chromones; Claudin-2; Down-Regulation; Epigenesis, Genetic; Humans; Hydroxamic Acids; Lung Neoplasms; MicroRNAs; Morpholines; Nitriles; RNA, Messenger; Signal Transduction; Sulfones | 2017 |
Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Decitabine; DNA Methylation; Doxorubicin; Drug Synergism; Epigenesis, Genetic; Estradiol; Estrogens; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; MCF-7 Cells | 2017 |
Treatment of Donor Cells and Reconstructed Embryos with a Combination of Trichostatin-A and 5-aza-2'-Deoxycytidine Improves the Developmental Competence and Quality of Buffalo Embryos Produced by Handmade Cloning and Alters Their Epigenetic Status and Gen
Topics: Animals; Azacitidine; Buffaloes; Cloning, Organism; Decitabine; Embryo, Mammalian; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Hydroxamic Acids; Male | 2017 |
HLJ1 (DNAJB4) Gene Is a Novel Biomarker Candidate in Breast Cancer.
Topics: Adult; Azacitidine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cohort Studies; CpG Islands; Decitabine; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; HSP40 Heat-Shock Proteins; Humans; Hydroxamic Acids; Kaplan-Meier Estimate; Precision Medicine; RNA, Messenger | 2017 |
Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer.
Topics: Anticarcinogenic Agents; Azacitidine; beta Catenin; Caspase 3; Cell Proliferation; Cyclin D1; Decitabine; Disease Progression; Epigenesis, Genetic; Estrogen Receptor beta; Hormones; Humans; Hydroxamic Acids; Male; Methylation; Nitriles; Propionates; Prostate; Prostatic Neoplasms; Vascular Endothelial Growth Factor A | 2018 |
Epigenetic modification of intestinal smooth muscle cell phenotype during proliferation.
Topics: Actins; Animals; Azacitidine; Cell Proliferation; Crohn Disease; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histone Deacetylase 2; Histone Deacetylases; Humans; Hydroxamic Acids; Ileum; Inflammation; Intestinal Mucosa; Intestines; Muscle Contraction; Myocytes, Smooth Muscle; Rats | 2018 |
In vivo conversion of astrocytes to oligodendrocyte lineage cells using chemicals: targeting gliosis for myelin repair.
Topics: Animals; Astrocytes; Azacitidine; Brain; Cell Differentiation; Cell Lineage; Cell Transplantation; Cellular Reprogramming Techniques; Demyelinating Diseases; Epigenomics; Gliosis; Humans; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Oligodendroglia | 2018 |
Benzene metabolite 1,2,4-benzenetriol changes DNA methylation and histone acetylation of erythroid-specific genes in K562 cells.
Topics: Acetylation; Azacitidine; Benzene; Cell Differentiation; DNA Methylation; GATA1 Transcription Factor; Globins; Hemin; Histone Deacetylase Inhibitors; Histones; Humans; Hydroquinones; Hydroxamic Acids; K562 Cells; RNA Polymerase II | 2019 |
Male reproductive tract antimicrobial expression in the extremes of ages of rats.
Topics: Aging; Animals; Azacitidine; beta-Defensins; Gene Expression Regulation; Genitalia, Male; Glycopeptides; Hydroxamic Acids; Lipopolysaccharides; Male; Rats; Rats, Wistar | 2019 |
PON1 hypermethylation is associated with progression of renal cell carcinoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aryldialkylphosphatase; Azacitidine; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; CpG Islands; Databases, Genetic; Disease Progression; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Kidney Neoplasms; Mice; Mice, Nude; Sunitinib; Transplantation, Heterologous | 2019 |
5-Azacytidine and trichostatin A enhance the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from steroid-induced avascular necrosis of the femoral head in rabbit.
Topics: Alkaline Phosphatase; Animals; Azacitidine; beta Catenin; Cell Differentiation; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Femur Head Necrosis; Humans; Hydroxamic Acids; Mesenchymal Stem Cells; Osteogenesis; Osteonecrosis; Rabbits; Steroids; Wnt Signaling Pathway | 2019 |
The Effect of Ras Homolog C/Rho-Associated Coiled-Protein Kinase (Rho/ROCK) Signaling Pathways on Proliferation and Apoptosis of Human Myeloma Cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Proliferation; Humans; Hydroxamic Acids; Multiple Myeloma; Protein Kinase Inhibitors; rho GTP-Binding Proteins; rho-Associated Kinases; RNA, Messenger; Signal Transduction | 2019 |
Ancestral Folate Promotes Neuronal Regeneration in Serial Generations of Progeny.
Topics: Administration, Oral; Animals; Axons; Azacitidine; DNA Methylation; Female; Folic Acid; Genome; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Intraperitoneal; Male; Nerve Regeneration; Neurons; Phenotype; Rats, Sprague-Dawley; Transcription, Genetic | 2020 |
Azacitidine, as a DNMT Inhibitor Decreases hTERT Gene Expression and Telomerase Activity More Effective Compared with HDAC Inhibitor in Human Head and Neck Squamous Cell Carcinoma Cell Lines.
Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Survival; DNA Methylation; DNA Modification Methylases; Drug Development; Enzyme Activation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Peptide Fragments; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Telomerase | 2021 |
5-Azacytidine upregulates melatonin MT
Topics: Animals; Azacitidine; Cell Line; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Histone Deacetylase Inhibitors; Hydroxamic Acids; Melatonin; Rats; Receptor, Melatonin, MT1; Receptors, Melatonin; RNA, Messenger; Transcriptional Activation; Valproic Acid | 2020 |
The DNMT1-associated lncRNA UCA1 was upregulated in TK6 cells transformed by long-term exposure to hydroquinone and benzene-exposed workers via DNA hypomethylation.
Topics: Azacitidine; Benzene; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Humans; Hydroquinones; Hydroxamic Acids; Occupational Exposure; Promoter Regions, Genetic; RNA, Long Noncoding; Up-Regulation | 2021 |
5-Azacitidine and Trichostatin A induce DNA damage and apoptotic responses in tongue squamous cell carcinoma: An in vitro study.
Topics: Azacitidine; Carcinoma, Squamous Cell; Decitabine; DNA Damage; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Tongue; Tongue Neoplasms | 2022 |
Trichostatin A-Mediated Epigenetic Modulation Predominantly Triggers Transcriptomic Alterations in the Ex Vivo Expanded Equine Chondrocytes.
Topics: Animals; Azacitidine; Chondrocytes; Decitabine; DNA Methylation; Epigenesis, Genetic; Epigenomics; Histone Deacetylase Inhibitors; Histones; Horses; Hydroxamic Acids; Transcriptome | 2022 |