azacitidine has been researched along with isomethyleugenol in 520 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 231 (44.42) | 18.7374 |
| 1990's | 140 (26.92) | 18.2507 |
| 2000's | 70 (13.46) | 29.6817 |
| 2010's | 75 (14.42) | 24.3611 |
| 2020's | 4 (0.77) | 2.80 |
| Authors | Studies |
|---|---|
| Friedman, S | 1 |
| Bezdĕk, M; Fajkus, J; Vyskot, B | 1 |
| Jansson, A; Masucci, M; Rymo, L | 1 |
| Altiok, E; Contreras-Brodin, B; Ernberg, I; Hu, LF; Klein, G; Minarovits, J | 1 |
| Baik, M; Park, CS | 1 |
| Bezdĕk, M; Koukalová, B; Kuhrová, V; Vyskot, B | 1 |
| Abbruzzese, JL; Anzai, H; Frost, P | 1 |
| Basham, TY; Merigan, TC; Reid, TR | 1 |
| Commane, M; McIntyre, P; Perry, ME; Rolfe, M; Stark, GR | 1 |
| Abbruzzese, JL; Frost, P | 1 |
| Crowther, P; Davidson, S; Radley, J; Woodcock, D | 1 |
| Thomas, GA; Williams, ED | 1 |
| De Greve, H; Hernalsteens, JP; Renckens, S; Van Montagu, M | 1 |
| Bird, A | 1 |
| Fujii, J; Fusamoto, H; Hayashi, N; Kamada, T; Miyoshi, E; Taniguchi, N; Towata, T; Ueda, K | 1 |
| Pinney, RJ; Radnedge, L | 2 |
| Gartler, SM; Hansen, RS; Sasaki, T | 1 |
| Grant, JH; Kudlow, JE; Meluch, AA; Paterson, AJ; Shin, TH | 1 |
| Biard, DS; Maratrat, M; Melcion, C; Sarasin, A; Thybaud, V | 1 |
| Pandit, NN; Russo, VE | 1 |
| Baik, JH; Bulle, F; Chikhi, N; Giuili, G; Guellaën, G; Siegrist, S | 1 |
| Amigorena, S; Bonnerot, C; Daëron, M; Even, J; Fridman, WH | 1 |
| Hoehn, H; Koehler, J; Poot, M; Priest, JH; Rabinovitch, PS | 1 |
| Beitel, G; Foster, R; Gedamu, L; Jahroudi, N; Price-Haughey, J | 1 |
| Hudson, JL; Liebling, MR; Richardson, BC | 1 |
| Dycaico, MJ; Kohler, SW; Kretz, PL; Provost, GS; Short, JM; Sorge, JA | 1 |
| Gartler, SM; Hansen, RS | 1 |
| Cedar, H; Razin, A | 1 |
| Athanassakis-Vassiliadis, I; Galanopoulos, VK; Grigoriou, M; Papamatheakis, J | 1 |
| Lutze, LH; Morgan, WF; Phillips, JW; Winegar, RA | 1 |
| Abbruzzese, JL; Ellis, M; Frost, P; Hunt, B; Lee, D | 1 |
| Chieco-Bianchi, L; Panozzo, M; Saggioro, D | 1 |
| Chaplin, DD; Webb, GC | 1 |
| Feick, A; Kohler, SW; Kretz, PL; Provost, GS; Short, JM | 1 |
| Kraakman, ME; Lambert, M; Schuurman, RK; van den Elsen, PJ; van Eggermond, MC | 1 |
| Cosgrove, DE; Cox, GS | 1 |
| Momparler, LF; Momparler, RL; Onetto-Pothier, N | 1 |
| Kuipers, AG; Mooibroek, H; Punt, PJ; Sietsma, JH; Wessels, JG | 1 |
| Bona, R; Cozzi, R; D'Erme, M; Palitti, F; Perticone, P | 1 |
| Fried, M; Heard, E | 1 |
| Storch, TG | 1 |
| Graessmann, A; Weber, H; Ziechmann, C | 1 |
| Breindl, M; Chan, H; Hartung, S | 1 |
| Hoeben, RC; Migchielsen, AA; van der Eb, AJ; van der Jagt, RC; van Ormondt, H | 1 |
| Bassin, RH; Rimoldi, D; Samid, D; Srikantan, V; Wilson, VL | 1 |
| Andrulis, IL; Kerbel, RS; Worton, KS | 1 |
| Hsieh, LL; Weinstein, IB | 1 |
| Chen, J; Jones, PA | 1 |
| Chou, TC; Kong, XB; Tong, WP | 1 |
| Milstone, DS; Parker, KL; Schimmer, BP; Seidman, JG; Szyf, M | 1 |
| Kaplan, G; Racaniello, VR | 1 |
| Gellersen, B; Kempf, R | 1 |
| Call, KM; Thilly, WG | 1 |
| Catravas, GN; Kalinich, JF; Snyder, SL | 1 |
| Kurosawa, T; Ookawara, T; Sugiyama, T; Suzuki, K; Taniguchi, N | 1 |
| Becker, PB; Nitsch, D; Reik, A; Schütz, G; Weih, F | 1 |
| Costello, JF; Erickson, LC; Futscher, BW; Kroes, RA; Marathi, U; Pieper, RO | 1 |
| Chalkley, R; Faber, S; Granner, D; Ip, T | 1 |
| Aleixandre, C; Costantino, MA; de Capoa, A; Felli, MP; Giancotti, P; Grappelli, C; Miller, DA; Poggesi, I; Ravenna, L; Vicenti, O | 1 |
| Galanti, N; Rojas, MV | 1 |
| Nyce, J | 1 |
| Airapetyan, VO; Kir'yanov, GI; Zatsepina, OV | 1 |
| Farrar, WL; Ruscetti, FW; Young, HA | 1 |
| Gattoni-Celli, S; Hsiao, WL; Weinstein, IB | 2 |
| Karlsson, S; Nienhuis, AW | 1 |
| Kerr, SJ | 1 |
| Abramian, DS; Glebov, OK | 1 |
| Alvarez, E; Frost, P; Kerbel, RS; Liteplo, RG | 1 |
| Suk, WA | 1 |
| Jones, PA | 3 |
| Greig, R; Kline, T; Mallon, F; Poste, G; Trainer, DL | 1 |
| Cooper, IA; Crowther, PJ; Simmons, DL; Woodcock, DM | 1 |
| Jones, PA; Taylor, SM | 3 |
| Selker, EU; Stevens, JN | 1 |
| Benvenisty, N; Razin, A; Reshef, L | 1 |
| Feldmesser, E; Kafri, T; Razin, A; Szyf, M | 1 |
| Benvenisty, N; Mencher, D; Razin, A; Reshef, L; Szyf, M | 1 |
| Everett, CA; Hart, IR; Ormerod, EJ | 1 |
| Buisson, N; Gourdji, D; Laverriere, JN; Martial, JA; Muller, M; Tixier-Vidal, A; Tougard, C | 1 |
| Bouchard, J; Momparler, RL; Samson, J | 1 |
| Balling, R; Bernstein, A; Hozumi, N; Huszar, D; Kothary, R; Magli, MC; Rossant, J | 1 |
| Gregory, P; Wang, N | 1 |
| Jones, PA; Kautiainen, TL | 1 |
| Berger, C; Coyle-Morris, J; Gemmill, RM; Glover, TW; Pearce-Birge, L | 1 |
| DeSimone, J; Hall, L; Heller, P; Lavelle, D; Zwiers, D | 1 |
| Hickey, I; Jones, S; O'Neill, K | 1 |
| Altevogt, P | 1 |
| Hudson, J; Kahn, L; Lovett, EJ; Richardson, B | 1 |
| Frost, P; Kerbel, RS; Liteplo, R | 1 |
| Barbé, J; Gibert, I; Guerrero, R | 1 |
| Gonzalez, FJ; Nebert, DW; Peterson, TC | 1 |
| Everett, CA; Finch, M; Hart, IR; Ormerod, EJ | 1 |
| Kaysen, J; Kufe, D; Spriggs, D | 1 |
| Amelotti, F; Barbieri, R; Bernardi, F; Buzzoni, D; Conconi, F; del Senno, L; Marchetti, G; Patracchini, P; Piva, R; Rossi, M | 1 |
| Adra, CN; McBurney, MW; Paterno, GD | 1 |
| Cooper, IA; Crowther, PJ; Morley, AA; Simmons, DL; Trainor, KJ; Woodcock, DM | 1 |
| Holliday, R | 1 |
| Hildebrandt, A | 1 |
| Barra, Y; Isselbacher, KJ; Jay, G; Khoury, G; Tanaka, K | 1 |
| Crawford, BD; Hildebrand, CE; Stallings, RL; Tesmer, J; Tobey, RA | 1 |
| Bartolucci, S; Bouchard, J; Momparler, LF; Momparler, RL; Nucci, R; Raia, CA; Rossi, M; Sepe, S; Vaccaro, C | 1 |
| Buisson, N; Gourdji, D; Laverrière, JN; Martial, JA; Morin, A; Muller, M; Tixier-Vidal, A; Truong, AT | 1 |
| Canivet, M; Emanoil-Ravier, R; Lasneret, J; Lesser, J; Périès, J | 1 |
| Nettesheim, P; Walker, C | 1 |
| Lassar, AB; Paterson, BM; Weintraub, H | 1 |
| Fairweather, DS; Fox, M; Margison, GP | 1 |
| Ivarie, R; Morris, JA | 1 |
| Holliday, R; Jeggo, PA | 1 |
| Bongarzone, I; Borrello, MG; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA | 1 |
| Branno, M; Maharajan, P; Maharajan, V; Scarano, E | 1 |
| Richardson, B | 1 |
| Carter, DB; Kovacs, EJ; Oppenheim, JJ; Young, HA | 1 |
| Jones, PA; Michalowsky, LA | 4 |
| Gyger, M; Momparler, RL; Rivard, GE | 1 |
| Frahm, J; Hoshino, J; Kröger, H | 2 |
| Hamada, J; Hosokawa, M; Ishikawa, M; Kobayashi, H; Okada, F | 1 |
| Honda, S; Matsuo, M | 1 |
| Matthews, AM; Shay, JW; Walker, C | 1 |
| Gunter, KC; Sneller, MC | 1 |
| Hotta, J; Loh, PC | 1 |
| Borri-Voltattorni, C; Dominici, P; Fioretti, MC; Fuschiotti, P; Puccetti, P; Romani, L | 1 |
| Antonsson, BE; Avramis, VI; Holcenberg, JS; Nyce, J | 1 |
| Ellis, N; Gartler, SM; Keitges, E; Rocchi, M | 1 |
| Ihara, T; Kurishita, A | 1 |
| Azuma, M; Hayashi, Y; Sato, M; Yanagawa, T; Yoshida, H; Yura, Y | 1 |
| Cozzi, R; Gustavino, B; Perticone, P | 1 |
| Lee, JS; O'Neill, L | 1 |
| Kuratomi, Y; Kuwano, M; Masumi, S; Ono, M; Yasutake, C | 1 |
| Heuertz, S; Homman, N; Hors-Cayla, MC | 1 |
| Essani, K; Goorha, R; Granoff, A | 1 |
| Blyth, WA; Hill, TJ; Whitby, AJ | 1 |
| Allegrucci, M; Borri Voltattorni, C; Dominici, P; Fioretti, MC; Puccetti, P; Romani, L | 1 |
| Bianchi, MS; Bianchi, NO; Larramendy, M | 1 |
| Banks, GR; Gounari, F; Holliday, R; Jeggo, PA; Khazaie, K | 1 |
| Charache, S; Dover, GJ | 1 |
| Chen, E; Ginder, GD; Karr, RW | 1 |
| Barbieri, R; Fisher, PB; Gambari, R; Giacomini, P; Natali, PG; Piva, R; Tecce, R | 1 |
| Ananthaswamy, HN | 1 |
| Csordas, A; Rossi, K; Schauenstein, K | 1 |
| Avramis, VI; Powell, WC | 1 |
| Lee, YH; Lin, JY; Lo, SJ; Pao, CC | 1 |
| Alvarez, E; Elliott, BE; Houghton, AN; Kerbel, RS | 1 |
| Bernstein, DI; Kappes, JC; Stephanopoulos, DE | 1 |
| Déry, CV; Horvath, J; Robert, N; Tellier, R; Toth, M; Weber, JM | 1 |
| Del Senno, L; Fasulo, MP; Pancaldi, S; Poli, F; Vannini, GL | 1 |
| Bare, RM; McDowell, AE; Miller, MS; Waalkes, MP; Wilson, MJ | 1 |
| Amigorena, S; Bonnerot, C; Daëron, M; Even, J; Fridman, WH; Hogarth, PM; Varin, N | 1 |
| Biedler, JL; Melera, PW; Michitsch, RW | 1 |
| Dürst, M; Rösl, F; zur Hausen, H | 1 |
| Pfeifer, GP; Steigerwald, SD | 1 |
| Bruckschen, M; Pott, U; Sies, H; Wagner, G | 1 |
| Furano, AV; Nur, I; Pascale, E | 1 |
| Burns, LJ; Ginder, GD; Glauber, JG | 1 |
| Albury, D; Johnson-Thompson, M | 1 |
| Cano, C; Herrera-Estrella, L; Ruiz-Herrera, J | 1 |
| DeMars, R; Korn, N; Nadon, N | 1 |
| Bongarzone, I; Borrello, MG; Cattadori, MR; Della Porta, G; Donghi, R; Mondellini, P; Pierotti, MA; Traversari, C | 1 |
| al-Ubaidi, MR; Frazier, ML; Kellems, RE; Siciliano, MJ; Stallings, RL | 1 |
| Weetman, AP | 1 |
| Szpirer, C; Vanhamme, L | 1 |
| den Dulk, H; Giphart-Gassler, M; Tasseron-de Jong, JG; van de Putte, P | 1 |
| Emerson, CP; Pinney, DF | 1 |
| Fioretti, MC; Fuschiotti, P; Puccetti, P; Romani, L | 1 |
| Contreras-Salazar, B; Ernberg, I; Falk, K; Klein, G; Masucci, MG; Minarovits, J; Ragnar, E | 1 |
| Avramis, VI; Mecum, RA; Powell, WC | 2 |
| Araki, K; Inomoto, T; Iwanaga, T; Matsubara, K; Miyazaki, J; Tsurimoto, T; Yamamura, K | 1 |
| Brüggemann, U; Doerfler, W; Knust, B | 1 |
| Avramis, VI; Holcenberg, JS; Mecum, RA; Nyce, J; Steele, DA | 1 |
| Andrews, DF; Nemunaitis, J; Singer, JW; Tompkins, C | 1 |
| Augusti-Tocco, G; Bartolucci, S; Estenoz, M; Longo, A; Momparler, RL; Rossi, M; Santoro, B | 1 |
| Constantinides, PG; Davis, CM; Gevers, W; Parker, MI; van der Riet, F; van Schalkwyk, L | 1 |
| Diver, WP; Woodcock, DM | 1 |
| Adra, CN; Hockey, AJ; McBurney, MW | 1 |
| Cecchini, E; Citti, L; Durante, M; Geri, C; Natali, L; Nuti Ronchi, V; Parenti, R | 1 |
| Farooq, M; Holliday, R; Hunter, JL; Matsumura, T | 1 |
| Bouchard, J | 1 |
| Busson, P; Ernberg, I; Falk, K; Klein, G; Masucci, MG; Minarovits, J; Tursz, T | 1 |
| Amasino, RM; John, MC | 1 |
| Chen, XR; Shi, ZZ; Yu, YN | 1 |
| Biswas, DK; Chisholm, J; Kumar, V; Pasion, SG; Rivera, RT; Zhang, ZX | 1 |
| Chandler, LA; Jones, PA | 1 |
| Aleström, P; Gautvik, KM; Parrow, VC | 1 |
| Kwok, FW; Ng, SF | 1 |
| Blau, HM; Chiu, CP | 1 |
| Denda, A; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
| Benvenisty, N; Mencher, D; Meyuhas, O; Razin, A; Reshef, L | 1 |
| Abruzzo, MA; Jacobs, PA; Mayer, M | 1 |
| Adams, RL; Burdon, RH; Davis, T; Kirk, D; Rinaldi, A | 1 |
| Ferraro, M; Lavia, P | 2 |
| Anderson, WF; Baur, A; Berg, P; Bernstein, S; DiPietro, J; Humphries, RK; Nienhuis, AW | 1 |
| Depper, JM; Drogula, CL; Greene, WC; Krönke, M; Leonard, WJ; Waldmann, TA | 1 |
| Babiss, LE; Fisher, PB; Zimmer, SG | 1 |
| Korba, BE; Wilson, VL; Yoakum, GH | 1 |
| Ley, TJ; Nienhuis, AW | 1 |
| Adams, RL; Burdon, RH; Qureshi, M | 1 |
| Takimoto, K | 1 |
| Momparler, LF; Momparler, RL; Samson, J | 1 |
| Amasino, RM; Gordon, MP; Powell, AL | 1 |
| Ikushima, T | 1 |
| Canivet, M; Dianoux, L; Hojman-Montes de Oca, F; Lasneret, J; Périès, J; Ravicovitch-Ravier, R | 1 |
| Abbasi, MM; Beisler, JA; Glazer, RI; Peale, AL | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Mohandas, T; Shapiro, LJ; Sparkes, RS | 1 |
| Eisenman, R; Groudine, M; Weintraub, H | 1 |
| Compere, SJ; Palmiter, RD | 1 |
| Migeon, BR; Wolf, SF | 1 |
| Clough, DW; Davidson, RL; Kunkel, LM | 1 |
| Jones, PA; Mohandas, T; Shapiro, LJ; Taylor, SM | 1 |
| Ivarie, RD; Morris, JA | 1 |
| Adams, RL; Fulton, J; Kirk, D | 1 |
| Maharajan, V; Pratibha, M; Scarano, E; Tosi, L | 1 |
| Harris, M | 1 |
| Graves, JA | 1 |
| DeSimone, J; Hall, L; Heller, P; Zwiers, D | 1 |
| Bird, S; Cowing, D; Gusella, J; Hoffmann, JW; Steffen, D; Tabin, C; Weinberg, RA | 1 |
| Anagnou, NP; DeSimone, J; Humphries, RK; Keller, GH; Keller, P; Ley, TJ; Nienhuis, AW; Turner, PH; Young, NS | 1 |
| Benz, EJ | 1 |
| Christy, B; Scangos, G | 1 |
| Christman, JK; Herzog, D; Mendelsohn, N; Schneiderman, N | 1 |
| Adams, RL; Burdon, RH | 1 |
| Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM | 1 |
| Bolander, FF | 1 |
| Ishida, H; Niwa, O; Sugahara, T; Yokota, Y | 1 |
| Bedigian, HG; Copeland, NG; Jenkins, NA; Rodick, S; Salvatore, K | 1 |
| Jones, PA; Taylor, SM; Wilson, VL | 1 |
| Harris, JS; Lu, LJ; Randerath, K; Tseng, WC | 1 |
| Schwartz, SA | 1 |
| Jones, PA; Momparler, RL; Wilson, VL | 1 |
| Mohandas, T; Shapiro, LJ | 1 |
| Cremisi, C | 1 |
| Bouchard, J; Momparler, RL | 1 |
| Hori, TA | 1 |
| DeSimone, J; Heller, P; Ley, TJ; Nienhuis, AW; Noguchi, CT; Schechter, AN; Turner, PH | 1 |
| Boyer, S; Charache, S; Dover, G; Moyer, M; Smith, K; Talbot, CC | 1 |
| Canivet, M; Emanoil-Ravicovitch, R; Hojman-Montes de Oca, F; Lasneret, J; Peries, J; Tobaly, J | 1 |
| Cooper, DN | 1 |
| Anisowicz, A; Gadi, IK; Harrison, JJ; Raffeld, M; Sager, R | 1 |
| Dev, VG; Mixon, JC | 1 |
| Appella, E; Jay, G; Tanaka, K | 1 |
| Antequera, F; Santos, T; Tamame, M; Villanueva, JR | 1 |
| Kolata, G | 1 |
| Frost, P; Kerbel, RS; Liteplo, RG | 1 |
| Clarke, LE; Hepburn, AG; Pearson, L; White, J | 1 |
| Jones, PA; Taylor, SM; Wilson, V | 1 |
| Anagnou, NP; DeSimone, J; Heller, P; Ley, TJ; Nienhuis, AW; Noguchi, CT; Schechter, AN | 1 |
| Boyer, SH; Charache, SH; Dover, GJ; Smith, KD; Talbot, CC | 1 |
| DeSimone, J; Duncan, CH; Heller, P; Schimenti, JC | 2 |
| Chase, RA; Ginder, GD; Kelley, K; Whitters, M | 1 |
| Beardsley, GP; Letvin, NL; Linch, DC; McIntyre, KW; Nathan, DG | 1 |
| Adamson, JW | 1 |
| Constantinides, PA; Jones, PA; Taylor, SM | 1 |
| Christman, JK | 1 |
| Bouchard, J; Momparler, RL; Onetto, N; Rivard, GE | 1 |
| Gattoni-Celli, S; Hsiao, WL; Kirschmeier, P; Weinstein, IB | 1 |
| Delers, A; Saggioro, D; Szpirer, C; Szpirer, J | 1 |
| Forchhammer, J; Olsson, L | 1 |
| Chiang, KS; Feng, TY | 1 |
| Priest, JH; Shafer, DA | 1 |
| Basilico, C; Liboi, E | 1 |
| Hoffman, RM | 1 |
| Amelotti, F; Barbieri, R; Bernardi, F; del Senno, L; Gambari, R | 1 |
| Carlow, DA; Elliott, BE; Frost, P; Kerbel, RS; Liteplo, R | 1 |
| Chiswell, DJ; Gillespie, DA; Searle, S; Wyke, JA | 1 |
| Cheong, LC; Friedman, S | 1 |
| Barr, PJ; Garrett, CE; Santi, DV | 1 |
| Barbieri, R; del Senno, L; Fantoni, A; Gambari, R; Raschellà, G; Tripodi, M; Viola, L | 1 |
| Lan, NC | 1 |
| Glazer, RI; Knode, MC | 1 |
| Guha, S | 1 |
| Lu, LJ; Randerath, K | 1 |
| Anagnou, NP; Anderson, WF; Chiang, YL; Haidaris, D; Ley, TJ; Wilson, VL | 1 |
| Fang, FD | 1 |
| Goorha, R; Granoff, A; Murti, KG; Willis, DB | 1 |
| DeSimone, J; Heller, P | 1 |
| Amelotti, F; Barbieri, R; Bernardi, F; Conconi, F; del Senno, L; Gambari, R; Piva, R; Viola, L | 1 |
| Carr, BI; Reilly, JG; Riggs, A; Smith, SS; Winberg, C | 1 |
| Flatau, E; Gonzales, FA; Jones, PA; Michalowsky, LA | 1 |
| Bouck, N; Kokkinakis, D; Ostrowsky, J | 1 |
| Strobl, JS; Thompson, EB | 1 |
| DeSimone, J; Duncan, CH; Heller, P; Lavelle, D; Schimenti, JC | 1 |
| Ho, T; Holliday, R | 1 |
| Claeys, KM; Foss, HM; Roberts, CJ; Selker, EU | 1 |
| Kurihara, K; Matsuoka, I; Mizuno, N; Okuse, K | 1 |
| Augusti-Tocco, G; Bartolucci, S; Carpinelli, P; Granata, F; Rossi, M | 1 |
| Schulz, WA; Teubner, B | 1 |
| Adylova, AT; Atakhanova, BA; Turakulov, IaKh; Umarova, GD | 1 |
| Dolnick, BJ; Hsueh, CT | 1 |
| Liu, WM; Maraia, RJ; Rubin, CM; Schmid, CW | 1 |
| Ehrlich, R; Katz, SL | 1 |
| De Cabo, SF; Fernández-Piqueras, J; Hazen, MJ; Molero, ML | 1 |
| Hsieh, CL | 1 |
| Esnault, C; Lai, E; Lee, H | 1 |
| Gutierrez, JC; Martin-Gonzalez, A; Palacios, G | 1 |
| Baik, MG; Choi, YJ; Roh, SG; Woo, JH | 1 |
| Gerard, JR; Ghosh, P; Lederer, J; Lichtman, A; McGurn, ME; Melvin, AJ; Penix, L; Wilson, CB; Ye, J; Young, HA | 1 |
| Hooper, F; O'Rourke, K; Powers, D; Richardson, B; Yung, RL | 1 |
| Benvenuto, G; Bruni, CB; Chiariotti, L; Colantuoni, V; Rossi, E; Salvatore, P; Zarrilli, R | 1 |
| Bezdĕk, M; Holý, A; Koukalová, B; Kovarík, A | 1 |
| Cashman, NR; Ledoux, S; Nalbantoglu, J | 1 |
| Lee, CH; Wei, LN | 1 |
| Campos, A; Fernández, JL; Gosálvez, J; Goyanes, V; Pereira, S | 1 |
| Farrell, PJ; Holder, A; Palmero, I; Peters, G; Sinclair, AJ | 1 |
| Gartler, SM; Goldman, MA | 1 |
| Dixon-McCarthy, B; Gill, TJ; Kunz, HW; Yuan, XJ | 1 |
| Jahan, N; Mitsuya, H; O'Brien, MC; Ueno, T; Zajac-Kaye, M | 1 |
| Chrisp, CE; Johnson, KJ; Quddus, J; Richardson, BC; Yung, RL | 1 |
| Ambinder, RF; Barletta, J; Robertson, KD; Samid, D | 1 |
| Richardson, BC; Yung, RL | 1 |
| Georgiev, G; Grigorian, M; Lukanidin, E; Tkatch, T; Tulchinsky, E | 1 |
| Haaf, T | 1 |
| Bhagwat, AS; Gabbara, S | 1 |
| Christie, NT; Costa, M; Dowjat, K; Kargacin, B; Kitahara, J; Klein, CB; Lee, YW; Salnikow, K; Zhitkovich, A | 1 |
| Bourgeois, CA; Delattre, JY; Dutrillaux, AM; Dutrillaux, B; Kokalj-Vokac, N; Malfoy, B; Poisson, M; Vega, F | 1 |
| Baylin, SB; Davidson, NE; Ferguson, AT; Lapidus, RG | 1 |
| Gourdji, D; Laverrière, JN; Ngô, VM | 1 |
| Podimatas, T; Zagris, N | 1 |
| Avramis, VI; Kees, UR | 1 |
| Caspary, WJ; Gibis, P; Körber, C; Spencer, DL; Stopper, H | 1 |
| Hirohashi, S; Kanai, Y; Ochiai, A; Shimoyama, Y; Sugimura, T; Yoshiura, K | 1 |
| Blann, E; Hammons, GJ; Lyn-Cook, BD; Nichols, J; Warren, GJ | 1 |
| Ambinder, RF; Hayward, SD; Ling, PD; Robertson, KD; Samid, D | 1 |
| Chen, W; Coxon, AB; Kaye, FJ; Khleif, SN; Otterson, GA | 1 |
| de la Torre, C; Leyton, C; Mergudich, D; Sans, J | 1 |
| Baylin, SB; Burger, PC; Gabrielson, E; Herman, JG; Lee, DJ; Mao, L; Merlo, A; Sidransky, D | 1 |
| Riggs, AD; Singer-Sam, J | 1 |
| Chu, C; Shen, CK | 1 |
| Abbruzzese, JL; Chernajovsky, Y; Ellerhorst, JA; Frost, P; Newman, RA | 1 |
| Hoehn, H; Poot, M; Weller, EM | 1 |
| Lendahl, U; Nilsson, E | 1 |
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| Buhlmann, JE; Green, WR; Kuhne, MR; Lam, TM; Schwarz, DA; White, HD | 1 |
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| Chan, E; Marquez, VE; Sun, F; Wu, Z; Yang, X; Yu, Q | 1 |
| Bussey, KJ; Ho, J; Ikediobi, O; Lorenzi, P; Nishizuka, S; Pommier, YG; Reimers, MA; Reinhold, WC; Shankavaram, UT; Weinstein, JN; Ziegler, MS | 1 |
| Frame, D | 1 |
| Cheng, W; Du, X; Huang, Q; Huang, W; Jiang, L; Lai, D; Liu, T; Liu, Z; Xu, F; Zhao, Y | 1 |
| Issa, JP | 1 |
| Kimmins, S; Lambrot, R | 1 |
| Chen, M; Patterson, AJ; Xiao, D; Xue, Q; Zhang, L | 1 |
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| Gao, F; Liang, Y; Lu, Q; Tang, J; Wu, X; Yin, H; Zhao, M | 1 |
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| Arimondo, PB; Champion, C; Guianvarc'h, D; Guieysse-Peugeot, AL; Jeltsch, A; Jurkowska, RZ; Ponger, L; Sénamaud-Beaufort, C | 1 |
| El-Rifai, W; Hu, T; Jackson, K; Marshal, D; Peng, D; Soutto, M | 1 |
| Godsey, S; Oyer, JA; Turker, MS; Yates, PA | 1 |
| Ran, Y; Wu, S; You, Y | 1 |
| Chen, Y; Fan, X; Huang, C; Song, T; Wang, T; Wu, P; Yang, J; Zhang, J | 1 |
| Dong, ZM; Fang, XH; Ge, MH; Hu, FJ; Li, P; Ling, ZQ; Mao, WM; Zhao, X | 1 |
| Morales-Ramírez, P; Rodríguez-Reyes, R | 1 |
| Li, W; Matsumura, F; Vogel, CF; Wong, P; Wu, D | 1 |
| Chim, CS; Chung, LP; Jin, DY; Lam, WW; Li, GK; Liang, R; Loong, F; So, CC; Wong, KY | 1 |
| Jiang, P; Lee, W; Li, W; Xiang, Y; Yu, G; Zhang, Y | 1 |
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| Bieblová, J; Bubeník, J; Indrová, M; Mikyšková, R; Polláková, V; Reiniš, M; Símová, J; Stěpánek, I | 1 |
| Blanco-Fernández, A; Dempsey, E; Harvey, DJ; Madden, SF; Mariño, K; McCann, A; Peracaula, R; Pérez-Garay, M; Rudd, PM; Saldova, R; Struwe, WB; Watson, JA | 1 |
| Berglundh, T; Larsson, L; Rymo, L; Thorbert-Mros, S | 1 |
| Blatt, K; Cerny-Reiterer, S; Ghanim, V; Hadzijusufovic, E; Heller, G; Herrmann, H; Karlic, H; Mirkina, I; Peter, B; Pickl, WF; Schuch, K; Valent, P; Zöchbauer-Müller, S | 1 |
| Chen, H; Jin, F; Liu, C; Mao, XY; Wang, H; Wei, J; Yao, F; Zheng, HC | 1 |
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| Chen, LH; Cheng, LY; Cherng, CG; Kao, GS; Su, CC; Tzeng, WY; Wang, CY; Yu, L | 1 |
| Chen, PW; Li, H; Mellon, J; Niederkorn, JY; Sadegh, L | 1 |
| Borden, EC; Fruehauf, JP; Haney, R; Jacobs, BS; Lindner, DJ; Tuthill, R; Wu, Y | 1 |
| Bollag, G; Bornman, WG; Davies, MA; Dayyani, F; Desai, J; Gallick, GE; Gopal, YN; Jiang, ZQ; Kopetz, S; Lemos, R; Mao, M; Mariadason, JM; Mills, GB; Powis, G; Tang, XM; Tian, F; Tsao, CC; Wistuba, II | 1 |
| Akria, L; Arad, A; Aviv, A; Braester, A; Dally, N; Filanovsky, K; Gafter-Gvili, A; Gatt, ME; Hellmann, I; Herishanu, Y; Herzog-Tzarfati, K; Leiba, R; Merkel, D; Mittelman, M; Nagler, A; Nemets, A; Ofran, Y; Ronson, A; Rouvio, O; Silbershatz, I; Tadmor, T; Vidal, L; Yeganeh, S | 1 |
| Chen, Y; Cui, X; Hu, H; Jiao, Y; Li, S; Lin, L; Lv, X; Song, E; Wang, M; Yao, H; Yu, F | 1 |
| Brock, MV; Guo, M; Herman, JG; Licchesi, JD; Liu, X; Pei, X; Yang, Y; Yue, W; Zhang, X | 1 |
| Ito, Y; Murrell, A; Nativio, R | 1 |
| Gong, T; Jia, SJ; Lai, YQ; Zhang, BK; Zhao, M | 1 |
| Cao, M; Lü, CX; Quan, XQ; Ruan, L; Shang, SS; Wang, G; Wu, XF; Xu, RD; Yan, FQ; Zhang, CT | 1 |
| Liu, Z; Zhang, L; Zhang, S; Zhang, W; Zhang, Y | 1 |
| Drews, M; Frycz, BA; Jagodziński, PP; Marciniak, R; Murawa, D; Murawa, P; Wysocki-Borejsza, M | 1 |
| Alp, E; Konac, E; Menevse, S; Yilmaz, A | 1 |
| Hsu, CL; Kuo, CC; Li, HJ; Lin, WC; Lin, YW; Yan, MD; Yu, PN | 1 |
| Benedetti, D; Bomben, R; Caldana, C; D'Arena, G; Dal Bo, M; Del Poeta, G; Di Raimondo, F; Gaidano, G; Gattei, V; Hartmann, TN; Hutterer, E; Pozzato, G; Pozzo, F; Rossi, D; Rossi, FM; Tissino, E; Zaja, F; Zucchetto, A | 1 |
| Chen, P; Chen, Y; He, Z; Peng, H; Zeng, H; Zhang, H; Zhang, Y | 1 |
| Buchi, F; Gozzini, A; Masala, E; Rossi, A; Sanna, A; Santini, V; Spinelli, E; Valencia, A | 1 |
| Buer, J; Geffers, R; Kehrmann, J; Probst-Kepper, M; Steinmann, J; Tatura, R; Zeschnigk, M | 1 |
| Chen, HX; Liu, H; Wang, S; Wang, Z | 1 |
| Ali, D; Bengtzen, S; Deneberg, S; Kanduri, M; Karimi, M; Kimby, E; Lehmann, S; Lennartsson, A; Mansouri, L; Qu, Y; Rosenquist, R | 1 |
| Bernasconi, MJ; Frederick, DT; Gunda, V; Parangi, S; Wargo, JA | 1 |
| Hu, C; Jin, J; Li, K; Mei, C; Ren, Z; Tong, H; Vera, JC; Zhuang, Z | 1 |
| Dawn, B; Elias, HK; Malik, AB; Rajasingh, J; Rajasingh, S; Simpson, AD; Sundivakkam, PK; Thangavel, J; Vogel, SM; Xuan, YT | 1 |
| Fu, B; Li, ZQ; Liu, D; Ma, H; Qi, MY; Wang, L; Wang, WT; Zhang, X; Zhang, YL | 1 |
| Cao, JL; Peng, YN; Tang, LH; Wang, Y; Yan, M; Yu, LN; Zhou, XL | 1 |
| Byon, J; Deeg, HJ; Holman, ZJ; Jiang, PY; Karoopongse, E; Marcondes, AM; Ramakrishnan, A; Yeung, C; Yu, Q | 1 |
| Agrawal, R; Gomez-Pinilla, F; Tyagi, E; Ying, Z; Zhuang, Y | 1 |
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| Agrawal, H; Chauhan, MS; Manik, RS; Palta, P; Saini, M; Selokar, NL; Singla, SK | 1 |
| Jiang, X | 1 |
| Chen, XJ; Li, YJ; Li, YY; Liu, ZY; Sun, ZL; Xie, WJ; Zhang, DS | 1 |
| Bohnsack, MT; Günnigmann, MA; Haag, S; Höbartner, C; Kretschmer, J; Warda, AS | 1 |
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| Affinito, O; Belardo, C; Chiariotti, L; Cristino, L; De Novellis, V; Errico, F; Florio, E; Imperatore, R; Keller, S; Luongo, L; Maddaloni, G; Maione, S; Migliarini, S; Nuzzo, T; Pasqualetti, M; Pollegioni, L; Punzo, D; Sacchi, S; Sisalli, MJ; Usiello, A | 1 |
| Katula, KS; Rumph, C; Vaidya, H | 1 |
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| Arnold, RD; Cummings, BS; Glenn, TC; Kolli, RT; Moore, M; Scholpa, NE | 1 |
| Clozel, T; Elemento, O; Erdem, Z; Hassler, MR; Krzywinski, M; Robinson, BD; Shariat, SF; Xylinas, E; Zhuang, D | 1 |
| Chen, YS; Chuang, PC; Huang, YH; Ko, JY; Lee, MS; Lian, WS; Sun, YC; Wang, FS; Weng, WT; Wu, SL | 1 |
| Butter, R; Linnekamp, JF; Medema, JP; Spijker, R; van Laarhoven, HWM | 1 |
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| Diamantopoulos, PT; Dimou, M; Dryllis, G; Galanopoulos, A; Giannakopoulou, N; Giannopoulos, A; Hatzidavid, S; Kontandreopoulou, CN; Kotsianidis, I; Loupis, T; Panayiotidis, P; Pappa, V; Solomou, E; Symeonidis, A; Viniou, NA; Zoi, K | 1 |
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| Ades, L; Balabanian, K; Bisio, V; Boy, M; Caignard, A; Clappier, E; Dulphy, N; Espeli, M; Fain, O; Fenaux, P; Gagne, K; Guidez, F; Henry, G; Kim, R; Larcher, L; Lereclus, E; Mekinian, A; Retiere, C; Rodrigues-Lima, F; Schell, B; Sebert, M; Toubert, A; Villemonteix, J; Zhao, LP | 1 |
28 review(s) available for azacitidine and isomethyleugenol
| Article | Year |
|---|---|
The essentials of DNA methylation.
Topics: Animals; Azacitidine; DNA; Methylation; Methyltransferases; Models, Biological; Promoter Regions, Genetic | 1992 |
DNA methylation and development.
Topics: Animals; Azacitidine; DNA; Embryonic and Fetal Development; Methylation; Transcription, Genetic; X Chromosome | 1990 |
Developmental regulation of human globin genes.
Topics: Azacitidine; Chromatin; Chromosome Deletion; Chromosomes, Human, 16-18; Chromosomes, Human, 6-12 and X; Enhancer Elements, Genetic; Fetal Hemoglobin; Gene Expression Regulation; Genes; Globins; Hemoglobins; Humans; Methylation; Mutation; Poly A; Promoter Regions, Genetic; Protein Biosynthesis; Repetitive Sequences, Nucleic Acid; RNA Caps; RNA Processing, Post-Transcriptional; RNA, Messenger; Thalassemia; Transcription Factors | 1985 |
Effects of 5-azacytidine and its 2'-deoxyderivative on cell differentiation and DNA methylation.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Transformation, Neoplastic; Chromosomes; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Genes, Viral; Humans; Methylation; Phenotype; Species Specificity | 1985 |
DNA methylation and cancer.
Topics: Animals; Azacitidine; Cell Division; DNA (Cytosine-5-)-Methyltransferases; DNA Replication; DNA, Neoplasm; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Neoplasms | 1986 |
DNA methylation and drug resistance in variants of C3H10T1/2 C1 8 cells.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Decitabine; DNA; Drug Resistance; Embryo, Mammalian; Gene Expression Regulation; Methylation; Mice; Muscles | 1986 |
10T1/2 cells: an in vitro model for molecular genetic analysis of mesodermal determination and differentiation.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Cells, Cultured; Gene Expression Regulation; In Vitro Techniques; Mesoderm; Methylation; Mice; Oncogenes; Stem Cells; Transcriptional Activation | 1989 |
Hypomethylation of DNA in the regulation of gene expression.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Differentiation; Cytosine; DNA; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms | 1988 |
Altering gene expression with 5-azacytidine.
Topics: Anemia, Sickle Cell; Animals; Azacitidine; Cell Differentiation; Cell Line; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Fetal Hemoglobin; Gene Expression Regulation; Genes; Genes, Regulator; Methylation; Mutation; Neoplasms; Thalassemia; Thymidine Kinase | 1985 |
Induction of hemoglobin F synthesis in patients with beta thalassemia.
Topics: Animals; Azacitidine; DNA; Erythroblasts; Female; Fetal Hemoglobin; Gene Expression Regulation; Globins; Humans; Hydroxyurea; Methylation; Papio; Thalassemia | 1985 |
DNA methylation in eukaryotes.
Topics: 5-Methylcytosine; Aging; Animals; Azacitidine; Base Sequence; Chromatin; Cytosine; Deoxyribonuclease HpaII; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction Enzymes; DNA-Cytosine Methylases; Gene Expression Regulation; Globins; Methylation; Nucleic Acid Conformation; Ovalbumin | 1982 |
Eukaryotic DNA methylation.
Topics: 5-Methylcytosine; Animals; Azacitidine; Base Composition; Cell Differentiation; Chromosome Mapping; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; DNA Replication; Eukaryotic Cells; Gene Expression Regulation; Genes; Genes, Viral; Humans; Methylation; Models, Genetic; Mutation; Transcription, Genetic; Transformation, Genetic | 1983 |
DNA modification, differentiation, and transformation.
Topics: 5-Methylcytosine; Animals; Azacitidine; Carcinogens; Cell Differentiation; Cell Line; Cell Survival; Cricetinae; Cricetulus; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Fibroblasts; Humans; Methylation; Mice; Papio; Phenotype; Rats; Transformation, Genetic | 1983 |
5-Azacytidine, DNA methylation, and differentiation.
Topics: 5-Methylcytosine; Azacitidine; Cell Differentiation; Cytidine; Cytosine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dosage Compensation, Genetic; Female; Gene Expression Regulation; Genes, Viral; Methylation; Methyltransferases; Nucleic Acids; Phosphorylation; RNA, Transfer; X Chromosome | 1984 |
DNA methylation in friend erythroleukemia cells: the effects of chemically induced differentiation and of treatment with inhibitors of DNA methylation.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Differentiation; Cell Line; Cytosine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Friend murine leukemia virus; Gene Expression Regulation; Globins; Leukemia, Erythroblastic, Acute; Methylation; Mice | 1984 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
Possible epigenetic mechanisms of tumor progression: induction of high-frequency heritable but phenotypically unstable changes in the tumorigenic and metastatic properties of tumor cell populations by 5-azacytidine treatment.
Topics: Animals; Azacitidine; DNA; Ethyl Methanesulfonate; Humans; Mammary Neoplasms, Experimental; Methylation; Methylnitronitrosoguanidine; Models, Genetic; Mutation; Neoplasm Metastasis; Neoplasms; Neoplastic Stem Cells; Phenotype; Stem Cells | 1984 |
5-Azacytidine and fetal hemoglobin.
Topics: Adult; Anemia, Sickle Cell; Animals; Azacitidine; Carcinogens; Disease Models, Animal; DNA; Fetal Hemoglobin; Gene Expression Regulation; Humans; Male; Methylation; Middle Aged; Papio; Thalassemia | 1984 |
Reactivation of inactive X-linked genes.
Topics: Aging; Animals; Azacitidine; Cell Fusion; Dosage Compensation, Genetic; Gene Expression Regulation, Developmental; Germ Cells; Humans; Methylation; X Chromosome | 1994 |
Role of T cell DNA methylation in lupus syndromes.
Topics: Azacitidine; DNA; Humans; Lupus Erythematosus, Systemic; Lymphocyte Function-Associated Antigen-1; Methylation; Procainamide; T-Lymphocytes | 1994 |
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinogens; Chromosomes; Decitabine; DNA Replication; Humans; Methylation | 1995 |
X chromosome inactivation and DNA methylation.
Topics: Animals; Azacitidine; Base Sequence; Chromatin; Dinucleoside Phosphates; DNA; Embryonic and Fetal Development; Female; Humans; Male; Methylation; Molecular Sequence Data; Phosphoglycerate Kinase; Sex Chromosome Aberrations; X Chromosome; Y Chromosome | 1993 |
DNA methylation: its possible functional roles in developmental regulation of human globin gene families.
Topics: Adult; Animals; Azacitidine; Base Sequence; Chromatin; DNA; DNA-Binding Proteins; Fetus; Gene Expression Regulation; Globins; Humans; Methylation; Multigene Family; Promoter Regions, Genetic; TATA Box; Transfection | 1993 |
Reactivation of silenced genes and transcriptional therapy.
Topics: Acetylation; Azacitidine; Chromatin; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Methylation; Transcriptional Activation | 2003 |
Epigenetic changes in the myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Azacitidine; Cell Transformation, Neoplastic; Decitabine; DNA Methylation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Leukemia, Myeloid; Methylation; Myelodysplastic Syndromes; Neoplasms; Protein Processing, Post-Translational | 2010 |
[TET2 dysregulation in hematologic malignancies].
Topics: Azacitidine; Cytosine; Decitabine; Dioxygenases; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Genetic Predisposition to Disease; Hematologic Neoplasms; Humans; Methylation; Molecular Targeted Therapy; Multigene Family; Mutation; Neoplasm Proteins; Proto-Oncogene Proteins | 2014 |
Clinical and biological effects of demethylating agents on solid tumours - A systematic review.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cytidine; Decitabine; DNA Methylation; Humans; Hydralazine; Immune System; Methylation; Neoplasms; Procaine; Treatment Outcome | 2017 |
Catalytic crosslinking-based methods for enzyme-specified profiling of RNA ribonucleotide modifications.
Topics: Animals; Azacitidine; Biocatalysis; Cross-Linking Reagents; Escherichia coli Proteins; Fluorouracil; Humans; Immunoprecipitation; Methylation; Methyltransferases; Multienzyme Complexes; Pseudouridine; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome; Uridine | 2019 |
3 trial(s) available for azacitidine and isomethyleugenol
| Article | Year |
|---|---|
Clinical trial on 5-aza-2'-deoxycytidine in patients with acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Antineoplastic Agents; Azacitidine; Cell Cycle; Cell Differentiation; Child; Clinical Trials as Topic; Decitabine; DNA, Neoplasm; Drug Evaluation; Humans; Leukemia; Methylation; Research Design | 1985 |
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Cell Cycle Proteins; Cell Differentiation; Child; Child, Preschool; Cohort Studies; Cyclin-Dependent Kinase Inhibitor p15; Decitabine; DNA Methylation; DNA Modification Methylases; Dose-Response Relationship, Drug; Female; Gene Silencing; Hematologic Neoplasms; Humans; Karyotyping; Leukemia; Male; Methylation; Middle Aged; Myeloproliferative Disorders; Time Factors; Treatment Outcome; Tumor Suppressor Proteins | 2004 |
A phase II study of 5-day intravenous azacitidine in patients with myelodysplastic syndromes.
Topics: Aged; Antimetabolites, Antineoplastic; Azacitidine; Humans; Injections; Methylation; Middle Aged; Myelodysplastic Syndromes; Remission Induction; Risk Assessment; Survival Analysis | 2009 |
489 other study(ies) available for azacitidine and isomethyleugenol
| Article | Year |
|---|---|
The effect of 5-azacytidine on E. coli DNA methylase.
Topics: Azacitidine; Chloramphenicol; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Escherichia coli; Kinetics; Methylation; Methyltransferases; Rifampin | 1979 |
Changes in chromatin structure due to hypomethylation induced with 5-azacytidine or DL-ethionine.
Topics: Azacitidine; Base Sequence; Chromatin; Chromosome Mapping; Deoxyribonucleases, Type II Site-Specific; DNA; Ethionine; Methylation; Micrococcal Nuclease; Molecular Sequence Data; Nicotiana; Nucleosomes; Plants, Toxic | 1992 |
Methylation of discrete sites within the enhancer region regulates the activity of the Epstein-Barr virus BamHI W promoter in Burkitt lymphoma lines.
Topics: Antigens, Viral; Azacitidine; Base Sequence; Burkitt Lymphoma; Deoxyribonuclease BamHI; DNA, Recombinant; DNA, Viral; Enhancer Elements, Genetic; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Methylation; Molecular Sequence Data; Promoter Regions, Genetic; Restriction Mapping; Transfection; Tumor Cells, Cultured | 1992 |
Host-cell-phenotype-dependent control of the BCR2/BWR1 promoter complex regulates the expression of Epstein-Barr virus nuclear antigens 2-6.
Topics: Antigens, Viral; Azacitidine; B-Lymphocytes; Base Sequence; Burkitt Lymphoma; DNA; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesvirus 4, Human; In Vitro Techniques; Methylation; Molecular Sequence Data; Nasopharyngeal Neoplasms; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; RNA, Messenger; RNA, Viral | 1992 |
Regulation of c-fos and ornithine decarboxylase mRNA levels by estrogen and 5-azacytidine.
Topics: 3T3 Cells; Animals; Azacitidine; Blotting, Northern; Estrogens; Gene Expression Regulation; Genes, fos; In Vitro Techniques; Methylation; Mice; Ornithine Decarboxylase; Proto-Oncogene Proteins c-fos; RNA, Messenger | 1992 |
Differential sensitivity of CG and CCG DNA sequences to ethionine-induced hypomethylation of the Nicotiana tabacum genome.
Topics: Azacitidine; Cytosine Nucleotides; DNA; Ethionine; Genome; Guanine Nucleotides; Methylation; Nicotiana; Plants, Toxic; Repetitive Sequences, Nucleic Acid | 1992 |
Synergistic cytotoxicity with 2'-deoxy-5-azacytidine and topotecan in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azacitidine; Camptothecin; Colorectal Neoplasms; Decitabine; DNA Topoisomerases, Type I; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Female; Lethal Dose 50; Methylation; Mice; Mice, Inbred BALB C; Topotecan; Tumor Cells, Cultured | 1992 |
Resistance to interferon-alpha in a mouse B-cell lymphoma involves DNA methylation.
Topics: Animals; Azacitidine; DNA; Drug Resistance; Ethyl Methanesulfonate; Interferon-alpha; Lymphoma, B-Cell; Methylation; Mice; Mutagenesis; Tumor Cells, Cultured | 1992 |
Induction of gene amplification by 5-aza-2'-deoxycytidine.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Azacitidine; Blotting, Southern; Cell Line; Cricetinae; Decitabine; DNA; Dose-Response Relationship, Drug; Drug Resistance; Gene Amplification; Mesocricetus; Methylation; Phosphonoacetic Acid | 1992 |
Studies on the mechanism of the synergistic interaction between 2'-deoxy-5-azacytidine and cisplatin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Cisplatin; Decitabine; DNA, Neoplasm; Drug Resistance; Drug Synergism; Humans; Melanoma; Methylation; Mice; Sensitivity and Specificity; Tubercidin; Tumor Cells, Cultured | 1992 |
Cytotoxicity of 5-aza-2'-deoxycytidine in a mammalian cell system.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Cricetinae; Cricetulus; Decitabine; DNA; Female; Methylation; Ovary | 1992 |
Production of thyroid tumours in mice by demethylating agents.
Topics: Animals; Azacitidine; Decitabine; DNA; Goiter; Methylation; Mice; Thyroid Neoplasms | 1992 |
Petunia plants escape from negative selection against a transgene by silencing the foreign DNA via methylation.
Topics: Agrobacterium tumefaciens; Amidohydrolases; Azacitidine; Blotting, Southern; Cell Line; Chromosome Deletion; Cloning, Molecular; DNA Transposable Elements; DNA, Bacterial; Gene Expression Regulation, Enzymologic; Methylation; Nucleic Acid Hybridization; Phenotype; Plants, Genetically Modified; Restriction Mapping; Selection, Genetic; Transformation, Genetic | 1992 |
Enhancement of hepatitis-B surface-antigen expression by 5-azacytidine in a hepatitis-B-virus-transfected cell line.
Topics: alpha-Fetoproteins; Azacitidine; Blotting, Southern; DNA, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Methylation; Transfection; Tumor Cells, Cultured | 1992 |
Increase in susceptibility to EcoRII restriction of bacteriophage lambda produced by propagation on host cells growing in 5-azacytidine: a new in-vivo method for demonstration of DNA-methylation inhibition.
Topics: Azacitidine; Bacteriophage lambda; Deoxyribonucleases, Type II Site-Specific; DNA, Viral; Escherichia coli; Methylation; Plasmids | 1992 |
Hemimethylation and hypersensitivity are early events in transcriptional reactivation of human inactive X-linked genes in a hamster x human somatic cell hybrid.
Topics: Animals; Azacitidine; Base Sequence; Chromatin; Cricetinae; Decitabine; Dinucleoside Phosphates; DNA; Dosage Compensation, Genetic; Genetic Linkage; Humans; Hybrid Cells; Hypoxanthine Phosphoribosyltransferase; Kinetics; Methylation; Molecular Sequence Data; RNA, Messenger; Transcription, Genetic; X Chromosome | 1992 |
5-Azacytidine treatment of HA-A melanoma cells induces Sp1 activity and concomitant transforming growth factor alpha expression.
Topics: Azacitidine; Base Sequence; DNA; Gene Expression Regulation; Humans; Kinetics; Melanoma; Methylation; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic; RNA, Messenger; Sp1 Transcription Factor; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1992 |
Flow cytometric detection of drugs altering the DNA methylation pattern.
Topics: Azacitidine; Base Sequence; beta-Galactosidase; Butyrates; Butyric Acid; Cell Cycle; Cell Transformation, Viral; Cells, Cultured; Decitabine; DNA, Bacterial; Escherichia coli; Flow Cytometry; Fluorometry; Gene Expression Regulation, Enzymologic; Humans; Kidney; Lac Operon; Methylation; Molecular Sequence Data; Transcription, Genetic | 1992 |
Reversible inactivation of a foreign gene, hph, during the asexual cycle in Neurospora crassa transformants.
Topics: Azacitidine; DNA, Fungal; Drug Resistance, Microbial; Genes; Methylation; Multigene Family; Neurospora crassa; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Recombination, Genetic; Restriction Mapping; Transformation, Genetic | 1992 |
Repetitive 5-azacytidine treatments of Fao cells induce a stable and strong expression of gamma-glutamyl transpeptidase.
Topics: Animals; Azacitidine; Cell Separation; Clone Cells; DNA; gamma-Glutamyltransferase; Gene Expression; Genome; Methylation; Rats; Tumor Cells, Cultured | 1992 |
Unmethylation of specific sites in the 5' region is critical for the expression of murine alpha Fc gamma R gene.
Topics: Animals; Antigens, Differentiation; Azacitidine; Blotting, Northern; Blotting, Southern; Cells, Cultured; Gene Expression Regulation; Interleukin-2; Leukocytes; Lymphocyte Activation; Lymphocytes; Macrophages; Mast Cells; Methylation; Mice; Receptors, Fc; Receptors, IgG; RNA, Messenger; Transcription, Genetic | 1990 |
Cell kinetic disturbances induced by treatment of human diploid fibroblasts with 5-azacytidine indicate a major role for DNA methylation in the regulation of the chromosome cycle.
Topics: Azacitidine; Bisbenzimidazole; Bromodeoxyuridine; Cell Cycle; Cells, Cultured; DNA; DNA Replication; Fibroblasts; Flow Cytometry; Humans; Methylation | 1990 |
Cell-type specific and differential regulation of the human metallothionein genes. Correlation with DNA methylation and chromatin structure.
Topics: Azacitidine; Carcinoma, Hepatocellular; Cell Line; Chloramphenicol O-Acetyltransferase; Chromatin; DNA; Gene Expression Regulation; Genes; Humans; Kinetics; Liver Neoplasms; Metallothionein; Methylation; Organ Specificity; Plasmids; Promoter Regions, Genetic; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1990 |
CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation.
Topics: Acecainide; Antibody Formation; Antigen-Presenting Cells; Antigens, CD; Antigens, Differentiation; Azacitidine; B-Lymphocytes; CD4-Positive T-Lymphocytes; Cell Differentiation; DNA; Histocompatibility Antigens; Humans; Hydroxyurea; Integrin beta1; Leukocyte Common Antigens; Methylation; Procainamide | 1990 |
Development of a short-term, in vivo mutagenesis assay: the effects of methylation on the recovery of a lambda phage shuttle vector from transgenic mice.
Topics: Animals; Azacitidine; Bacteriophage lambda; Blotting, Southern; Cells, Cultured; DNA; Escherichia coli; Ethylnitrosourea; Fibroblasts; Genetic Vectors; Methylation; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation | 1990 |
5-Azacytidine-induced reactivation of the human X chromosome-linked PGK1 gene is associated with a large region of cytosine demethylation in the 5' CpG island.
Topics: 5-Methylcytosine; Azacitidine; Cytosine; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Humans; Methylation; Phosphoglycerate Kinase; Regulatory Sequences, Nucleic Acid; Restriction Mapping; X Chromosome | 1990 |
Induction of class II MHC antigen expression on the murine placenta by 5-azacytidine correlates with fetal abortion.
Topics: Animals; Azacitidine; Blotting, Northern; Female; Fetal Death; Gene Expression; Gestational Age; Histocompatibility Antigens Class II; Immunoenzyme Techniques; Lymphocyte Activation; Major Histocompatibility Complex; Methylation; Mice; Mice, Inbred Strains; Placenta; Pregnancy; Pregnancy, Animal; Spleen; Trophoblasts | 1990 |
Chromosome aberration induction in Chinese hamster ovary cells by restriction enzymes with different methylation sensitivity.
Topics: Animals; Azacitidine; Cell Line; Chromosome Aberrations; Cricetinae; Cytosine; Decitabine; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Methylation; Substrate Specificity | 1990 |
Synergistic cytotoxicity using 2'-deoxy-5-azacytidine and cisplatin or 4-hydroperoxycyclophosphamide with human tumor cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line; Cell Survival; Cisplatin; Computer Graphics; Cyclophosphamide; Decitabine; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Methylation; Tumor Cells, Cultured | 1990 |
Human T-lymphotropic virus type I transcriptional regulation by methylation.
Topics: Azacitidine; Blotting, Southern; Cell Line; DNA, Viral; Gene Expression Regulation, Viral; Gene Products, gag; Human T-lymphotropic virus 1; Humans; Methylation; Proviruses; Repetitive Sequences, Nucleic Acid; Restriction Mapping; RNA, Viral; Transcription, Genetic | 1990 |
Genetic variability at the human tumor necrosis factor loci.
Topics: Azacitidine; Base Sequence; Cells, Cultured; Chromosome Mapping; DNA; Humans; Methylation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Tumor Necrosis Factor-alpha | 1990 |
The use of lambda phage shuttle vectors in transgenic mice for development of a short term mutagenicity assay.
Topics: Animals; Azacitidine; Bacteriophage lambda; Cells, Cultured; DNA Restriction-Modification Enzymes; Escherichia coli; Female; Fibroblasts; Genetic Vectors; Male; Methylation; Mice; Mice, Transgenic; Mutagenicity Tests; Mutation; Organ Specificity | 1990 |
The MHC class II deficiency syndrome: heterogeneity at the level of the response to 5-azadeoxycytidine.
Topics: Azacitidine; Cell Line, Transformed; Decitabine; DNA; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; Humans; Immunologic Deficiency Syndromes; Lymphocytes; Methylation; Promoter Regions, Genetic; Syndrome; Transcription, Genetic | 1990 |
Effects of sodium butyrate and 5-azacytidine on DNA methylation in human tumor cell lines: variable response to drug treatment and withdrawal.
Topics: 5-Methylcytosine; Azacitidine; Butyrates; Butyric Acid; Cytosine; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Dose-Response Relationship, Drug; HeLa Cells; Humans; Methylation; Tumor Cells, Cultured | 1990 |
Comparison of antineoplastic activity of cytosine arabinoside and 5-aza-2'-deoxycytidine against human leukemic cells of different phenotype.
Topics: Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; DNA; Humans; Leukemia; Methylation; Phenotype; Tumor Cells, Cultured | 1990 |
Introduction of hygromycin B resistance into Schizophyllum commune: preferential methylation of donor DNA.
Topics: Azacitidine; Blotting, Southern; Cloning, Molecular; Cytosine; DNA, Fungal; Drug Resistance, Microbial; Gene Expression Regulation, Fungal; Hygromycin B; Methylation; Schizophyllum; Transformation, Genetic | 1990 |
Persistence of azacytidine-induced SCEs and genomic methylation in CHO cells in vitro.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Cycle; Chromatography, High Pressure Liquid; Cricetinae; Cytosine; In Vitro Techniques; Methylation; Sister Chromatid Exchange | 1990 |
The use of 5-azacytidine to increase cleavage of methylation sensitive rare cutting restriction enzymes sites in amplified DNA.
Topics: Animals; Azacitidine; Cell Line; DNA; DNA Restriction Enzymes; Methylation; Nucleic Acid Amplification Techniques; Rats; Restriction Mapping | 1990 |
Oxygen concentration regulates 5-azacytidine-induced myogenesis in C3H/10T1/2 cultures.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Differentiation; Cell Line; Cytosine; DNA; Kinetics; Methylation; Mice; Mice, Inbred C3H; Muscles; Oxygen | 1990 |
In vitro DNA methylation inhibits gene expression in transgenic tobacco.
Topics: Amino Acid Oxidoreductases; Azacitidine; DNA; Gene Expression; Glucuronidase; Methylation; Mosaic Viruses; Nicotiana; Plants, Toxic; Polyethylene Glycols; Protoplasts; Restriction Mapping; Transfection; Transformation, Genetic | 1990 |
Retrovirus-induced interference with collagen I gene expression in Mov13 fibroblasts is maintained in the absence of DNA methylation.
Topics: Animals; Azacitidine; Base Sequence; Cell Line; Cell Transformation, Viral; Chromatin; Cloning, Molecular; Collagen; Gene Expression Regulation, Neoplastic; Methylation; Mice; Molecular Sequence Data; Moloney murine leukemia virus; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Transcription Factors; Transcription, Genetic; Xenopus laevis | 1991 |
Inactivation of the Moloney murine leukemia virus long terminal repeat in murine fibroblast cell lines is associated with methylation and dependent on its chromosomal position.
Topics: Animals; Azacitidine; beta-Galactosidase; Blotting, Southern; Cell Line; Chloramphenicol O-Acetyltransferase; DNA, Viral; Fibroblasts; Genetic Vectors; Methylation; Mice; Moloney murine leukemia virus; Plasmids; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; Transcription, Genetic | 1991 |
Increased sensitivity of nontumorigenic fibroblasts expressing ras or myc oncogenes to malignant transformation induced by 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Differentiation; Cell Line; Cell Survival; Cell Transformation, Neoplastic; Cocarcinogenesis; Decitabine; DNA; Genes, ras; Matrix Metalloproteinase 3; Metalloendopeptidases; Methylation; Mice; Mice, Nude; Neoplasm Metastasis; Proto-Oncogene Proteins c-myc; Proto-Oncogenes; RNA, Messenger | 1991 |
Hypomethylation and reactivation of the asparagine synthetase gene induced by L-asparaginase and ethyl methanesulfonate.
Topics: Asparaginase; Aspartate-Ammonia Ligase; Azacitidine; Cells, Cultured; DNA; Enzyme Induction; Ethyl Methanesulfonate; Gene Expression Regulation; Methylation; RNA, Messenger | 1991 |
Factors influencing the expression of endogenous retrovirus-like sequences in Rat 6 cells.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Animals; Azacitidine; Blotting, Northern; Cell Division; Cell Line; Cell Nucleus; Cycloheximide; Gene Expression Regulation, Viral; Growth Substances; Methylation; Rats; Retroviridae; RNA, Messenger; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1990 |
Potentiation of MyoD1 activity by 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Blotting, Northern; Bone and Bones; Cell Differentiation; Cloning, Molecular; Decitabine; DNA; Fluorescent Antibody Technique; Gene Expression Regulation; Humans; Methylation; Muscles; MyoD Protein; Nuclear Proteins; Phosphoproteins; Transfection; Tumor Cells, Cultured | 1990 |
Induction of deoxycytidine kinase by 5-azacytidine in an HL-60 cell line resistant to arabinosylcytosine.
Topics: Azacitidine; Base Sequence; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance; Enzyme Induction; Humans; Kinetics; Leukemia, Experimental; Leukemia, Myeloid; Methylation; Molecular Sequence Data; Time Factors; Tritium; Tumor Cells, Cultured | 1991 |
cis modification of the steroid 21-hydroxylase gene prevents its expression in the Y1 mouse adrenocortical tumor cell line.
Topics: Adrenal Cortex Neoplasms; Animals; Azacitidine; Bacterial Proteins; Cloning, Molecular; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Gene Expression; Methylation; Mice; Nucleic Acid Hybridization; RNA, Messenger; Steroid 21-Hydroxylase; Transfection; Tumor Cells, Cultured | 1990 |
Down regulation of poliovirus receptor RNA in HeLa cells resistant to poliovirus infection.
Topics: Azacitidine; Blotting, Southern; Down-Regulation; Gene Expression Regulation, Viral; Genes, Viral; HeLa Cells; Humans; Immunity, Innate; Methylation; Poliovirus; Receptors, Virus; RNA, Messenger; Sensitivity and Specificity | 1991 |
Human prolactin gene expression: positive correlation between site-specific methylation and gene activity in a set of human lymphoid cell lines.
Topics: Azacitidine; Base Sequence; Cell Line; Cloning, Molecular; Cytarabine; Deoxyribonuclease EcoRI; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Gene Expression; Humans; Lymphocytes; Methylation; Molecular Sequence Data; Nucleic Acid Hybridization; Prolactin | 1990 |
5-Azacytidine inhibits the induction of transient TK-deficient cells by 5-bromodeoxyuridine. A novel hypothesis for the facilitation of hypermethylation by 5-bromodeoxyuridine.
Topics: Azacitidine; Bromodeoxyuridine; Cell Cycle; Chromatography, High Pressure Liquid; Cytidine; Deoxycytidine; DNA; Dose-Response Relationship, Drug; Drug Antagonism; Gene Expression Regulation; Humans; In Vitro Techniques; Methylation; Mutation; Thymidine Kinase | 1991 |
Radioprotective properties of DNA methylation-disrupting agents.
Topics: 5-Methylcytosine; Animals; Azacitidine; Butyrates; Butyric Acid; Cell Survival; Cytosine; Depression, Chemical; DNA; In Vitro Techniques; Methylation; Radiation-Protective Agents; Stimulation, Chemical | 1991 |
High sensitivity to 5-azacytidine in LEC rats, a strain with a metabolic predisposition to hepatitis and hepatoma: possible involvement of DNA methylation in the expression of cytochrome P-450 and gamma-glutamyl transpeptidase.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cytochrome P-450 Enzyme System; Cytosine; Disease Susceptibility; DNA; DNA (Cytosine-5-)-Methyltransferases; gamma-Glutamyltransferase; Gene Expression Regulation, Enzymologic; Hepatitis, Animal; Liver; Liver Neoplasms, Experimental; Methylation; Rats; Rats, Mutant Strains | 1991 |
Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.
Topics: Azacitidine; Base Sequence; Blotting, Southern; Cells, Cultured; Chromatin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Dinucleoside Phosphates; DNA; DNA Fingerprinting; DNA-Binding Proteins; Methylation; Molecular Sequence Data; Tyrosine Transaminase | 1991 |
Direct correlation between methylation status and expression of the human O-6-methylguanine DNA methyltransferase gene.
Topics: Azacitidine; Blotting, Northern; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Restriction Mapping; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1991 |
The interplay of ubiquitous DNA-binding factors, availability of binding sites in the chromatin, and DNA methylation in the differential regulation of phosphoenolpyruvate carboxykinase gene expression.
Topics: Animals; Azacitidine; Base Sequence; Binding Sites; Cell Line; Chromatin; Cytosine; Deoxyribonuclease I; Dinucleoside Phosphates; DNA; DNA-Binding Proteins; Gene Expression Regulation; Methylation; Molecular Sequence Data; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; Rats; RNA, Messenger | 1991 |
Inheritance of ribosomal gene activity and level of DNA methylation of individual gene clusters in a three generation family.
Topics: Azacitidine; Cells, Cultured; Chromosomes, Human; DNA, Ribosomal; Female; Humans; Lymphocytes; Male; Methylation; Multigene Family; Nucleolus Organizer Region; Pedigree | 1991 |
Relationship between DNA methylation and cell proliferation in Trypanosoma cruzi.
Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; DNA; DNA Replication; DNA, Protozoan; Kinetics; Methylation; Oxygen Consumption; Thymidine; Trypanosoma cruzi | 1991 |
Gene silencing in mammalian cells by direct incorporation of electroporated 5-methyl-2'-deoxycytidine 5'-triphosphate.
Topics: 5-Methylcytosine; Animals; Azacitidine; Base Composition; Cell Division; Cell Line; Cell Survival; Cricetinae; Cytosine; Deoxycytosine Nucleotides; Drug Resistance; Gene Expression Regulation; Methylation; Mutagenesis; Thioguanine | 1991 |
Nucleolar activation during artificial demethylation of DNA in cultured pig embryonic kidney cells.
Topics: Animals; Azacitidine; Cell Nucleolus; Cells, Cultured; DNA; Gene Expression Regulation; Kidney; Methylation; RNA, Ribosomal; Transcription, Genetic | 1990 |
5-Azacytidine treatment of a murine cytotoxic T cell line alters interferon-gamma gene induction by interleukin 2.
Topics: Animals; Azacitidine; Cell Line; DNA Restriction Enzymes; Gene Expression Regulation; Genes; Interferon-gamma; Interleukin-2; Methylation; Mice; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Transcriptional Activation | 1985 |
Effects of 5-azacytidine on the progressive nature of cell transformation.
Topics: Animals; Azacitidine; Benzo(a)pyrene; Cell Adhesion; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Methylation; Mice | 1985 |
Induction of adipocyte formation in 10T1/2 cells by 1-methylguanine and 7-methylguanine.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; DNA; Guanine; Methylation; Mice; Neoplasms | 1985 |
[Genetic transformation of somatic cells. VIII. The effect of the DNA methylation inhibitor 5-azacytidine on the stability of thymidine kinase-negative and -positive phenotypes of transformant clone cells].
Topics: Animals; Azacitidine; Bromodeoxyuridine; Cell Transformation, Viral; Clone Cells; Cricetinae; Cricetulus; DNA; Drug Resistance; Genes, Viral; Methylation; Phenotype; Simplexvirus; Thymidine Kinase; Transformation, Genetic | 1985 |
Induction of thymidine kinase activity in a spontaneously enzyme-deficient murine tumor cell line by exposure in vivo to the DNA-hypomethylating agent 5-aza-2'-deoxycytidine: implications for mechanisms of tumor progression.
Topics: Animals; Azacitidine; Cell Line; Decitabine; DNA; Enzyme Induction; Male; Methylation; Mice; Mice, Inbred DBA; Mutation; Neoplasms, Experimental; Thymidine Kinase | 1985 |
Interaction between nontransforming retroviruses and chemicals in cells in vitro: association with progression to neoplastic phenotypes.
Topics: Animals; Azacitidine; Carcinogens; Cell Survival; Cell Transformation, Neoplastic; DNA; Methylation; Oncogenes; Phenotype; Rats; Rats, Inbred F344; Retroviridae | 1985 |
Effect of 5-azacytidine on DNA methylation and the malignant properties of B16 melanoma cells.
Topics: Animals; Azacitidine; Deoxycytidine; DNA, Neoplasm; Female; Lung Neoplasms; Melanoma; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis | 1985 |
Levels and stability of DNA methylation in random surviving cell clones derived from a Chinese hamster cell line after prolonged treatment with 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Cell Cycle; Cell Line; Cell Survival; Clone Cells; Cricetinae; Decitabine; Deoxycytidine; DNA; Female; Methylation; Ovary; Time Factors | 1986 |
Cellular differentiation.
Topics: Acetates; Acetic Acid; Adipose Tissue; Animals; Azacitidine; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; DNA; DNA (Cytosine-5-)-Methyltransferases; Gene Expression Regulation; Methylation; Mice; Mice, Inbred C3H; Triglycerides | 1985 |
DNA methylation at asymmetric sites is associated with numerous transition mutations.
Topics: 5-Methylcytosine; Azacitidine; Base Sequence; Biological Evolution; Cytosine; DNA, Ribosomal; Methylation; Mutation; Neurospora crassa | 1985 |
Developmental changes in the methylation pattern, chromatin conformation and expression of the rat phosphoenolpyruvate carboxykinase gene.
Topics: Animals; Azacitidine; Base Sequence; Chromatin; DNA; DNA Restriction Enzymes; Fetus; Genes; Liver; Methylation; Organ Specificity; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Spleen; Transcription, Genetic | 1985 |
Cell specific DNA methylation patterns; formation and a nucleosome locking model for their function.
Topics: Animals; Azacitidine; Cell Line; Dimethyl Sulfoxide; DNA, Neoplasm; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Experimental; Methylation; Mice; Models, Genetic; Nucleosomes; Thrombin | 1985 |
Tissue-specific hypomethylation and expression of rat phosphoenolpyruvate carboxykinase gene induced by in vivo treatment of fetuses and neonates with 5-azacytidine.
Topics: Animals; Animals, Newborn; Azacitidine; DNA; Female; Fetus; Genes; Liver; Methylation; Nucleic Acid Hybridization; Phosphoenolpyruvate Carboxykinase (GTP); Pregnancy; Rats; Rats, Inbred Strains; RNA; Spleen; Transcription, Genetic | 1985 |
Enhanced experimental metastatic capacity of a human tumor line following treatment with 5-azacytidine.
Topics: Animals; Azacitidine; Cytotoxicity, Immunologic; DNA, Neoplasm; Humans; Killer Cells, Natural; Lung Neoplasms; Melanoma; Methylation; Mice; Neoplasm Metastasis; Neoplasm Transplantation | 1986 |
Differential implication of deoxyribonucleic acid methylation in rat prolactin and rat growth hormone gene expressions: a comparison between rat pituitary cell strains.
Topics: Animals; Azacitidine; Cell Line; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; Gene Expression Regulation; Growth Hormone; Kinetics; Methylation; Nucleic Acid Hybridization; Pituitary Gland; Pituitary Neoplasms; Prolactin; Rats | 1986 |
Induction of differentiation and inhibition of DNA methylation in HL-60 myeloid leukemic cells by 5-AZA-2'-deoxycytidine.
Topics: Antineoplastic Agents; Azacitidine; Cell Differentiation; Cell Line; Decitabine; Dimethyl Sulfoxide; DNA; Dose-Response Relationship, Drug; Humans; Leukemia, Myeloid, Acute; Methylation; Superoxides | 1985 |
Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector.
Topics: Animals; Azacitidine; Drug Resistance; Gene Expression Regulation; Genes; Genes, Bacterial; Genetic Engineering; Genetic Vectors; Germ Cells; Helper Viruses; Leukemia Virus, Murine; Methylation; Mice; Neomycin; RNA, Messenger | 1985 |
Alterations in the X chromosome replication pattern induced by 5-azacytidine in a human tumor line.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Chromosome Banding; DNA Replication; Dosage Compensation, Genetic; Gene Expression Regulation; Humans; Methylation; X Chromosome | 1986 |
DNA methyltransferase levels in tumorigenic and nontumorigenic cells in culture.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cattle; Cells, Cultured; Cricetinae; Cytosine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Fibroblasts; Gene Expression Regulation; Humans; Mesocricetus; Methylation; Mice; Neoplasm Proteins; Neoplasms, Experimental; Rats | 1986 |
Effects of 5-azacytidine on expression of endogenous retrovirus-related sequences in C3H 10T1/2 cells.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA, Viral; Fibroblasts; Genes, Intracisternal A-Particle; Mammary Tumor Virus, Mouse; Methylation; Mice; Mice, Inbred C3H; Poly A; Repetitive Sequences, Nucleic Acid; Retroviridae; RNA; RNA, Messenger; RNA, Viral; Transcription, Genetic | 1986 |
DNA demethylation induced by 5-azacytidine does not affect fragile X expression.
Topics: Azacitidine; Cell Line; Chromosome Fragility; DNA; DNA Restriction Enzymes; Fragile X Syndrome; Gene Expression Regulation; Genetic Markers; Humans; Lymphocytes; Male; Methylation; X Chromosome | 1986 |
On the mechanism of Hb F elevations in the baboon by erythropoietic stress and pharmacologic manipulation.
Topics: Anemia, Hemolytic; Animals; Azacitidine; Cytarabine; DNA; Erythropoiesis; Fetal Hemoglobin; Hemorrhage; Hydroxyurea; Leukocyte Count; Methylation; Nucleic Acid Hybridization; Papio; Reticulocytes | 1986 |
Azacytidine induces reversion of thymidine kinase deficiency in Friend erythroleukemia cells.
Topics: Alleles; Animals; Azacitidine; Cell Line; Clone Cells; DNA; Dose-Response Relationship, Drug; Friend murine leukemia virus; Gene Expression Regulation; Leukemia, Erythroblastic, Acute; Methylation; Mice; Thymidine Kinase | 1986 |
Effects of mutagens on the immunogenicity of tumor cells: comparison of cell surface changes induced by 5-azacytidine and N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Animals; Azacitidine; Cell Line; DNA, Neoplasm; Epitopes; Lymphoma; Membrane Proteins; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred DBA; Mutagens; Neoplasm Transplantation; T-Lymphocytes, Cytotoxic | 1986 |
Effect of an inhibitor of DNA methylation on T cells. I. 5-Azacytidine induces T4 expression on T8+ T cells.
Topics: Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Azacitidine; Cell Cycle; Clone Cells; DNA; Humans; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Methylation; Phenotype; T-Lymphocytes | 1986 |
On the possible contribution of DNA hypomethylation to the induction of high frequency and heritable drug-induced alterations in the malignant phenotype.
Topics: Alkylating Agents; Animals; Azacitidine; Cell Line; DNA, Neoplasm; Gene Amplification; Humans; Methylation; Mice; Mutagens; Mutation; Neoplasms; Neoplasms, Experimental; Phenotype; Thymidine Kinase | 1986 |
5-Azacytidine: survival and induction of the SOS response in Escherichia coli K-12.
Topics: Adenosine Triphosphate; Azacitidine; Bacterial Proteins; Bacteriophage lambda; DNA (Cytosine-5-)-Methyltransferases; DNA Repair; Escherichia coli; Escherichia coli Proteins; Exodeoxyribonuclease V; Exodeoxyribonucleases; Genes, Bacterial; Methylation; Mitomycin; Mitomycins; Rec A Recombinases; Recombination, Genetic; Serine Endopeptidases; Ultraviolet Rays; Virus Activation | 1986 |
Methylation differences in the murine P1450 and P3450 genes in wild-type and mutant hepatoma cell culture.
Topics: Animals; Azacitidine; Base Sequence; Cells, Cultured; Cytochrome P-450 Enzyme System; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; Gene Amplification; Genes; Isoenzymes; Liver Neoplasms, Experimental; Methylation; Mice; Mutation; Polychlorinated Dibenzodioxins | 1986 |
DNA methylation levels in human and murine melanoma cell lines of varying metastatic potential.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Humans; Melanoma; Methylation; Mice; Neoplasm Metastasis | 1986 |
Incorporation of 5-fluorodeoxycytidine and metabolites into nucleic acids of human MCF-7 breast carcinoma cells.
Topics: Azacitidine; Breast Neoplasms; Cell Line; Cell Survival; Decitabine; Deoxycytidine; Deoxyuridine; DNA, Neoplasm; Floxuridine; Humans; Methylation; RNA, Neoplasm; Tetrahydrouridine | 1986 |
Methylation and expression of c-myc and c-abl oncogenes in human leukemic K562 cells before and after treatment with 5-azacytidine.
Topics: Azacitidine; Cell Differentiation; Cell Line; DNA Restriction Enzymes; DNA, Neoplasm; Humans; Leukemia, Myeloid; Methylation; Nucleic Acid Hybridization; Oncogenes | 1986 |
X chromosome reactivation in mouse embryonal carcinoma cells.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; DNA Replication; Dosage Compensation, Genetic; Gene Expression Regulation; Hypoxanthine Phosphoribosyltransferase; Methylation; Mice; Teratoma; Transcription, Genetic; X Chromosome | 1985 |
Delayed DNA methylation is an integral feature of DNA replication in mammalian cells.
Topics: Animals; Azacitidine; Cell Cycle; Cell Line; Cells, Cultured; Cricetinae; Decitabine; DNA; DNA Replication; Humans; Kinetics; Lymphocytes; Methylation; Mutation | 1986 |
Strong effects of 5-azacytidine on the in vitro lifespan of human diploid fibroblasts.
Topics: 5-Methylcytosine; Azacitidine; Cell Division; Cell Line; Cell Survival; Cytarabine; Cytosine; Decitabine; DNA; Fibroblasts; Humans; Methylation | 1986 |
Methylation is an early and necessary step in the sporulation programme of the slime mold Physarum polycephalum.
Topics: Azacitidine; Decitabine; DNA, Fungal; Ethionine; Methylation; Physarum; S-Adenosylhomocysteine; Spores, Fungal | 1986 |
Developmental and tissue-specific regulation of the Q10 class I gene by DNA methylation.
Topics: Animals; Animals, Newborn; Azacitidine; Base Sequence; DNA; Histocompatibility Antigens; Liver; Methylation; Mice; Mice, Inbred Strains; Nucleotide Mapping | 1986 |
5-Azacytidine-induced conversion to cadmium resistance correlates with early S phase replication of inactive metallothionein genes in synchronized CHO cells.
Topics: Animals; Azacitidine; Cadmium; Cell Line; Cricetinae; Cricetulus; DNA; DNA Replication; Drug Resistance; Genes; Interphase; Metallothionein; Methylation | 1986 |
5-AZA-2'-deoxycytidine synergistic action with thymidine on leukemic cells and interaction of 5-AZA-dCMP with dCMP deaminase.
Topics: Animals; Azacitidine; Cell Line; Cell Survival; DCMP Deaminase; Decitabine; Deoxycytosine Nucleotides; DNA, Neoplasm; Drug Synergism; Humans; Methylation; Mice; Nucleotide Deaminases; Thymidine; Thymine Nucleotides | 1986 |
[Regulation of prolactin and growth hormone gene expression in pituitary cell culture].
Topics: Animals; Azacitidine; Cells, Cultured; Gene Expression Regulation; Growth Hormone; Methylation; Pituitary Gland; Prolactin; Rats; Thyrotropin-Releasing Hormone; Transcription, Genetic | 1986 |
Simultaneous activation by 5-azacytidine of intracisternal R particles and murine intracisternal-A particle related sequences in Syrian hamster cells.
Topics: Animals; Azacitidine; Cell Line; Cricetinae; Gene Expression Regulation; Genes, Intracisternal A-Particle; Inclusion Bodies, Viral; Methylation; Microscopy, Electron; Proto-Oncogenes; RNA, Viral; Time Factors; Transcription, Genetic; Virus Replication | 1986 |
In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Decitabine; DNA; Dose-Response Relationship, Drug; Epithelium; Male; Methylation; Methylnitronitrosoguanidine; Mutation; Rats; Rats, Inbred F344; Time Factors; Trachea | 1986 |
Transfection of a DNA locus that mediates the conversion of 10T1/2 fibroblasts to myoblasts.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; DNA; Fibroblasts; Methylation; Mice; Muscles; Phenotype; Transfection | 1986 |
The in vitro lifespan of MRC-5 cells is shortened by 5-azacytidine-induced demethylation.
Topics: 5-Methylcytosine; Azacitidine; Cell Division; Cell Line; Cell Survival; Cytosine; DNA; Fibroblasts; Humans; Methylation | 1987 |
Activation of a nonexpressed hypoxanthine phosphoribosyltransferase allele in mutant H23 HeLa cells by agents that inhibit DNA methylation.
Topics: Alleles; Azacitidine; Azaserine; Ethyl Methanesulfonate; Genes; HeLa Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Methylation; Methylnitronitrosoguanidine; Mutation; Thioguanine | 1986 |
Azacytidine-induced reactivation of a DNA repair gene in Chinese hamster ovary cells.
Topics: Animals; Azacitidine; Cell Line; Cricetinae; Cricetulus; DNA Repair; Ethyl Methanesulfonate; Female; Methylation; Mutation; Ovary; X-Rays | 1986 |
DNA methylation affecting the transforming activity of the human Ha-ras oncogene.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Humans; Methylation; Mice; Oncogenes; Plasmids; Transfection | 1987 |
Effects of 5 azacytidine on DNA methylation and early development of sea urchins and ascidia.
Topics: Animals; Azacitidine; Blastocyst; DNA; Methylation; Protein Biosynthesis; RNA; Sea Urchins; Urochordata | 1986 |
Effect of an inhibitor of DNA methylation on T cells. II. 5-Azacytidine induces self-reactivity in antigen-specific T4+ cells.
Topics: Antibodies, Monoclonal; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface; Azacitidine; DNA; HLA Antigens; Humans; In Vitro Techniques; Lymphocyte Activation; Macrophages; Methylation; T-Lymphocytes | 1986 |
Enhanced interleukin-1 production by human monocyte cell lines following treatment with 5-azacytidine.
Topics: Azacitidine; Bromodeoxyuridine; Cell Line; DNA; Gene Expression Regulation; Humans; Interleukin-1; Lipopolysaccharides; Methylation; Monocytes; RNA, Messenger | 1987 |
Suppression of nuclear ADP-ribosyltransferase activity in Ehrlich ascites tumor cells by 5-azacytidine and its analogs.
Topics: Animals; Azacitidine; Carcinoma, Ehrlich Tumor; Cell Nucleus; Cytosine; DNA; Female; Hydroxyurea; Methylation; Mice; Mice, Inbred Strains; Poly(ADP-ribose) Polymerase Inhibitors | 1987 |
Changes in the tumorigenic and metastatic properties of tumor cells treated with quercetin or 5-azacytidine.
Topics: Animals; Azacitidine; Cell Line; DNA; Fibrosarcoma; Flavonoids; Methylation; Mice; Mice, Inbred C57BL; Mutagens; Neoplasm Metastasis; Neoplasm Transplantation; Phenotype; Quercetin | 1987 |
5-Azacytidine shortens the in vitro lifespan of human diploid cells.
Topics: Azacitidine; Cell Survival; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Fibroblasts; Humans; Methylation | 1987 |
Suppression of tumorigenicity mediated by 5-azacytidine and associated with increased chromosome number.
Topics: Animals; Azacitidine; Cell Line; Chromosomes; DNA, Neoplasm; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental | 1987 |
DNA methylation alters chromatin structure and regulates Thy-1 expression in EL-4 T cells.
Topics: 5-Methylcytosine; Animals; Antigens, Surface; Azacitidine; Cell Line; Chromatin; Cytosine; Decitabine; DNA, Neoplasm; Ethyl Methanesulfonate; Gene Expression Regulation; Lymphoma; Methylation; Mice; Mice, Inbred C57BL; RNA, Messenger; T-Lymphocytes; Thy-1 Antigens | 1987 |
Enhanced production of a human spumavirus (Retroviridae) in semi-permissive cell cultures after treatment with 5-azacytidine.
Topics: Azacitidine; Cells, Cultured; Dimethyl Sulfoxide; DNA; Humans; Methylation; Retroviridae; Time Factors; Transfection | 1987 |
DNA methylating activity in murine lymphoma cells xenogenized by triazene derivatives.
Topics: Animals; Azacitidine; Carmustine; Cell Line; Cytarabine; Dacarbazine; DNA, Neoplasm; Lymphoma; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Quinacrine; Triazenes | 1987 |
Suppression of nuclear ADP-ribosyltransferase activity in regenerating rat liver by 5-azacytidine and its relevance to the nuclear methylating activities.
Topics: Animals; Azacitidine; Cell Nucleus; Cytidine; DNA; Dose-Response Relationship, Drug; Female; Liver; Liver Regeneration; Methylation; Methyltransferases; Poly(ADP-ribose) Polymerase Inhibitors; Proteins; Rats; Rats, Inbred Strains; RNA | 1987 |
Effect of 5-azacytidine and congeners on DNA methylation and expression of deoxycytidine kinase in the human lymphoid cell lines CCRF/CEM/0 and CCRF/CEM/dCk-1.
Topics: Azacitidine; Cell Line; Cytarabine; Decitabine; Deoxycytidine Kinase; DNA; DNA (Cytosine-5-)-Methyltransferases; Drug Resistance; Humans; Lymphoid Tissue; Methylation; Phosphotransferases | 1987 |
High-frequency reactivation of X-linked genes in Chinese hamster X human hybrid cells.
Topics: Animals; Azacitidine; Cell Line; Cricetinae; Cricetulus; Dosage Compensation, Genetic; Gene Expression Regulation; Genetic Markers; Humans; Hybrid Cells; Methylation | 1987 |
Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Dose-Response Relationship, Drug; Female; Fetal Death; Limb Deformities, Congenital; Methylation; Pregnancy; Rats | 1987 |
5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone.
Topics: Adenocarcinoma; Amylases; Animals; Azacitidine; Cell Differentiation; Clone Cells; DNA; Humans; Methylation; Mice; Mice, Inbred BALB C; Myosins; Neoplasm Transplantation; Salivary Gland Neoplasms; Transplantation, Heterologous | 1987 |
Sister chromatid exchanges induced by DNA demethylating agents persist through several cell cycles in mammalian cells.
Topics: Animals; Azacitidine; Cell Cycle; Cells, Cultured; Cricetinae; Cricetulus; DNA; Ethionine; Humans; Methylation; Mitomycin; Mitomycins; Sister Chromatid Exchange; Ultraviolet Rays | 1987 |
Methylation of the HLA-DR alpha gene is positively correlated with expression.
Topics: Azacitidine; Cell Line; DNA; Gene Expression Regulation; HLA-D Antigens; HLA-DQ Antigens; HLA-DR Antigens; Humans; Interferon-gamma; Methylation; Nucleic Acid Hybridization; Transcription, Genetic | 1987 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neoplastic; DNA; Epidermal Growth Factor; Metallothionein; Methylation; Methylnitronitrosoguanidine; Mice; Mice, Inbred BALB C; Mutation; Proto-Oncogenes; Tetradecanoylphorbol Acetate | 1987 |
Time dependence of X gene reactivation induced by 5-azacytidine: possible progressive restructuring of chromatin.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Division; Cell Line; Chromatin; Cricetinae; Cytosine; Dosage Compensation, Genetic; Enzyme Induction; Female; Gene Expression Regulation; Humans; Hybrid Cells; Hypoxanthine Phosphoribosyltransferase; Methylation | 1987 |
Differential nuclear protein binding to 5-azacytosine-containing DNA as a potential mechanism for 5-aza-2'-deoxycytidine resistance.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cell Line; Cell Nucleus; Cytarabine; Cytosine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Drug Resistance; Methylation; Mice | 1987 |
Mutation in a DNA-binding protein reveals an association between DNA-methyltransferase activity and a 26,000-Da polypeptide in frog virus 3-infected cells.
Topics: Animals; Azacitidine; Cell Line; Chromatography, Affinity; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Genes, Viral; Iridoviridae; Methylation; Mutation; Peptides; Virus Replication | 1987 |
The effect of DNA hypomethylating agents on the reactivation of herpes simplex virus from latently infected mouse ganglia in vitro. Brief report.
Topics: Animals; Azacitidine; Dimethyl Sulfoxide; DNA, Viral; Ganglia, Sympathetic; Herpes Simplex; In Vitro Techniques; Methylation; Mice; Simplexvirus; Vero Cells; Virus Replication | 1987 |
DNA methylating activity in murine lymphoma cells treated with xenogenizing chemicals.
Topics: Animals; Azacitidine; Carmustine; DNA, Neoplasm; Leukemia L1210; Male; Methylation; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Triazenes | 1987 |
The asymmetric methylation of CG palindromic dinucleotides increases sister-chromatid exchanges.
Topics: Aedes; Animals; Azacitidine; Base Sequence; Cell Cycle; Cell Line; Cricetinae; Cricetulus; Cytosine; Dinucleoside Phosphates; Female; Guanine; Methylation; Oligonucleotides; Ovary; Sister Chromatid Exchange | 1988 |
Gene reactivation: a tool for the isolation of mammalian DNA methylation mutants.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Line; Cricetinae; Cricetulus; Decitabine; DNA; Ethyl Methanesulfonate; Female; Genes; Metallothionein; Methylation; Mutation; Nucleic Acid Hybridization; Ovary; Temperature; Thymidine Kinase | 1987 |
Increasing fetal hemoglobin production in sickle cell disease: results of clinical trials.
Topics: Anemia, Sickle Cell; Azacitidine; DNA; Fetal Hemoglobin; Hematopoietic Stem Cells; Humans; Hydroxyurea; Methylation; Reticulocytes | 1987 |
Negative and positive regulation of human leukocyte antigen class I gene transcription in K562 leukemia cells.
Topics: Azacitidine; DNA, Neoplasm; Drug Synergism; Gene Expression Regulation; HLA Antigens; Humans; Interferon-gamma; Kinetics; Leukemia; Methylation; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1987 |
Regulation of the expression of class II genes of the human major histocompatibility complex in tumor cells.
Topics: Azacitidine; B-Lymphocytes; DNA, Neoplasm; Gene Expression Regulation; Genes, MHC Class II; HLA-D Antigens; HLA-DR Antigens; Humans; Interferons; Leukemia, Erythroblastic, Acute; Major Histocompatibility Complex; Melanoma; Methylation; Recombinant Proteins; Tumor Cells, Cultured | 1987 |
Regulated expression of tumor-specific and MHC class I antigens in an ultraviolet radiation-induced murine skin cancer.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Decitabine; Gene Expression Regulation; H-2 Antigens; Histocompatibility Antigens; Interferon-gamma; Methylation; Mice; Neoplasms, Radiation-Induced; Skin Neoplasms; Ultraviolet Rays | 1988 |
Differential inhibition of mitogen induced T cell proliferation by 5-azacytidine and cytosine-arabinoside.
Topics: Animals; Azacitidine; Concanavalin A; Cytarabine; DNA; Gene Expression Regulation; Lymphocyte Activation; Male; Methylation; Rats; Rats, Inbred Strains; Spleen; T-Lymphocytes; Thymus Gland | 1988 |
Biochemical pharmacology of 5,6-dihydro-5-azacytidine (DHAC) and DNA hypomethylation in tumor (L1210)-bearing mice.
Topics: Animals; Azacitidine; Bone Marrow; Brain; Chromatography, High Pressure Liquid; DNA, Neoplasm; Erythrocytes; Intestinal Mucosa; Kidney; Leukemia L1210; Liver; Lung; Male; Methylation; Mice; Muscles; Myocardium; Spleen; Testis; Tissue Distribution; Tumor Cells, Cultured | 1988 |
Enhanced production of hepatitis B virus surface antigen in mouse C127 cell on a bovine papillomavirus-metallothionein vector.
Topics: Animals; Azacitidine; Cadmium; Cadmium Compounds; Cell Line; DNA, Recombinant; Genetic Vectors; Hepatitis B Surface Antigens; Metallothionein; Methylation; Mice; Papillomaviridae; Sulfates; Transfection | 1988 |
Heritable high frequency modulation of antigen expression in neoplastic cells exposed to 5-aza-2'-deoxycytidine or hydroxyurea: analysis and implications.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Decitabine; DNA, Neoplasm; Histocompatibility Antigens; Humans; Hydroxyurea; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methylation; Mice; Tumor Cells, Cultured | 1988 |
Enhanced in vitro reactivation of herpes simplex virus type 2 from latently infected guinea-pig neural tissues by 5-azacytidine.
Topics: Animals; Azacitidine; DNA, Viral; Ganglia, Spinal; Guinea Pigs; Herpes Simplex; Methylation; Organ Culture Techniques; Simplexvirus; Spinal Cord; Virus Activation | 1988 |
Activation of the major late promoter in adenovirus transformed cells by 5-azacytidine.
Topics: Adenoviridae; Animals; Azacitidine; Cell Line; Cell Transformation, Viral; DNA, Viral; Methylation; Promoter Regions, Genetic; Rats; Stimulation, Chemical; Transcription, Genetic | 1988 |
5-Azacytidine accelerates yeast-mycelium conversion in Candida albicans.
Topics: Azacitidine; Candida albicans; DNA, Fungal; Kinetics; Methylation | 1988 |
Increased metallothionein gene expression in 5-aza-2'-deoxycytidine-induced resistance to cadmium cytotoxicity.
Topics: Animals; Azacitidine; Cadmium; Cell Line; Cell Survival; Decitabine; DNA; DNA Restriction Enzymes; Dose-Response Relationship, Drug; Drug Resistance; Gene Expression Regulation; Hydroxyurea; Kinetics; Liver; Metallothionein; Methylation; Nucleic Acid Hybridization; Rats; Rats, Inbred F344 | 1988 |
Methylation in the 5' region of the murine beta Fc gamma R gene regulates the expression of Fc gamma receptor II.
Topics: Animals; Azacitidine; Cell Line; DNA; Ethyl Methanesulfonate; Gene Expression Regulation; Immunoglobulin G; Methylation; Mice; Receptors, Fc; Receptors, IgG; T-Lymphocytes | 1988 |
Modulation of N-myc expression, but not tumorigenicity, accompanies phenotypic conversion of neuroblastoma cells in prolonged culture.
Topics: Azacitidine; Cell Line; Cell Transformation, Neoplastic; Gene Amplification; Gene Expression Regulation; Humans; Methylation; Neuroblastoma; Oncogenes; Phenotype; Time Factors; Tumor Cells, Cultured | 1988 |
Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine.
Topics: Azacitidine; Cycloheximide; DNA, Viral; Humans; Hybrid Cells; Methylation; Papillomaviridae; Transcription, Genetic | 1988 |
Variable DNA methylation changes during differentiation of human melanoma cells.
Topics: Aphidicolin; Azacitidine; Cell Differentiation; Cell Division; Chromatography, High Pressure Liquid; Cytarabine; Decitabine; Diterpenes; DNA; DNA, Neoplasm; Humans; Hydroxyurea; Methylation; Monophenol Monooxygenase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1988 |
Effects of 5-azacytidine and methyl-group deficiency on NAD(P)H: quinone oxidoreductase and glutathione S-transferase in liver.
Topics: Animals; Azacitidine; Choline Deficiency; DNA; Electrophoresis, Agar Gel; Enzyme Induction; Glutathione Transferase; Liver; Male; Methionine; Methylation; Mice; Mice, Inbred Strains; NAD(P)H Dehydrogenase (Quinone); Quinone Reductases; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
The left end of rat L1 (L1Rn, long interspersed repeated) DNA which is a CpG island can function as a promoter.
Topics: Animals; Azacitidine; Base Composition; Biological Evolution; Chloramphenicol O-Acetyltransferase; Gene Expression Regulation; Methylation; Promoter Regions, Genetic; Rats; Regulatory Sequences, Nucleic Acid; Repetitive Sequences, Nucleic Acid; Transcription, Genetic | 1988 |
Butyrate induces selective transcriptional activation of a hypomethylated embryonic globin gene in adult erythroid cells.
Topics: Acetylation; Animals; Azacitidine; Blotting, Northern; Butyrates; Chickens; Gene Expression Regulation; Globins; Histones; Methylation; Phenylhydrazines; Reticulocytes; Transcription, Genetic; Transcriptional Activation | 1988 |
Azapyrimidine analogues: inhibition of viral DNA synthesis and protein synthesis in SV40 infected BSC-1 cells.
Topics: Animals; Azacitidine; Cell Line; Chlorocebus aethiops; DNA, Viral; Dose-Response Relationship, Drug; Methylation; Protein Biosynthesis; Simian virus 40; Structure-Activity Relationship; Virus Replication | 1988 |
DNA methylation and polyamines in regulation of development of the fungus Mucor rouxii.
Topics: Azacitidine; DNA, Fungal; Hydroxyurea; Methylation; Mucor; Polyamines; Putrescine; Spores, Fungal | 1988 |
A-11: cell type-specific and single-active-X transcription controls of newly found gene in cultured human cells.
Topics: Azacitidine; Blotting, Northern; Cell Line; Chromosome Mapping; Cloning, Molecular; DNA; Dosage Compensation, Genetic; Fibroblasts; Gamma Rays; Gene Expression Regulation; Genes; Humans; Lymphocytes; Methylation; Mutation; Restriction Mapping; RNA Splicing; Transcription, Genetic; X Chromosome | 1988 |
Modulation of the human Harvey-ras oncogene expression by DNA methylation.
Topics: Animals; Azacitidine; Blotting, Northern; Cell Line; Cell Transformation, Neoplastic; DNA; Gene Expression Regulation; Genes, ras; Humans; Methylation; Mice; Restriction Mapping; Transfection | 1988 |
Hypomethylation and ADA gene expression in mouse CAK cells.
Topics: Adenosine Deaminase; Animals; Azacitidine; Blotting, Northern; Blotting, Southern; Cell Line; Cricetinae; DNA; Gene Expression Regulation; Hybrid Cells; Isoenzymes; Methylation; Mice; Nucleoside Deaminases; Transcription Factors | 1989 |
Hypomethylation enhances Ia antigen expression by the FRTL5 rat thyroid cell line.
Topics: Animals; Azacitidine; Cell Line; Gene Expression Regulation; Histocompatibility Antigens Class II; Interferon-gamma; Methylation; Rats; Recombinant Proteins; Thyroid Gland | 1988 |
Spontaneous and 5-azacytidine-induced revertants of methionine-dependent tumor-derived and H-ras-1-transformed cells.
Topics: Animals; Azacitidine; Cell Division; Cell Line, Transformed; Cell Transformation, Neoplastic; Culture Media; Ethyl Methanesulfonate; Homocysteine; Methionine; Methylation; Oncogenes; Tumor Cells, Cultured | 1989 |
De novo methylation as major event in the inactivation of transfected herpesvirus thymidine kinase genes in human cells.
Topics: Azacitidine; Cell Line; Cloning, Molecular; Gene Expression Regulation; Humans; In Vitro Techniques; Methylation; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Selection, Genetic; Simplexvirus; Thymidine Kinase | 1989 |
DNA methylation and differentiation.
Topics: Animals; Azacitidine; Cell Differentiation; Decitabine; DNA; Gene Expression Regulation; Humans; In Vitro Techniques; Methylation | 1989 |
Lack of correlation between DNA-methylating activity and appearance of the immunogenic phenotype in clones of a murine lymphoma treated with mutagens.
Topics: 5-Methylcytosine; Animals; Antigens, Neoplasm; Azacitidine; Clone Cells; Cytosine; DNA, Neoplasm; Female; Leukemia L1210; Male; Methylation; Methylnitronitrosoguanidine; Mice; Mutagens; Phenotype; Triazenes | 1989 |
5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael.
Topics: Antigens, Viral; Azacitidine; Burkitt Lymphoma; Capsid; Cell Line; Epstein-Barr Virus Nuclear Antigens; Fluorescent Antibody Technique; Gene Expression Regulation; Genes; Genes, Viral; Herpesvirus 4, Human; Humans; Immunoblotting; Kinetics; Methylation; Viral Matrix Proteins | 1989 |
Gene structure and transcription in mouse cells with extensively demethylated DNA.
Topics: 5-Methylcytosine; Animals; Azacitidine; Chromatin; Clone Cells; Cytosine; Decitabine; DNA; Gene Expression Regulation; Methylation; Mice; Transcription, Genetic | 1989 |
Cellular metabolism of 5,6-dihydro-5-azacytidine and its incorporation into DNA and RNA of human lymphoid cells CEM/O and CEM/dCk(-).
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line; DNA, Neoplasm; Humans; Leukemia; Lymphocytes; Methylation; Mutation; RNA, Neoplasm; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |
Demethylation by 5-azacytidine results in the expression of hepatitis B virus surface antigen in transgenic mice.
Topics: Animals; Azacitidine; Blotting, Northern; Gene Expression Regulation; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Methylation; Mice; Mice, Transgenic; RNA, Messenger | 1989 |
Reactivation of a methylation-silenced gene in adenovirus-transformed cells by 5-azacytidine or by E1A trans activation.
Topics: Adenovirus Early Proteins; Adenoviruses, Human; Animals; Azacitidine; Blotting, Northern; Blotting, Southern; Cell Line, Transformed; DNA, Viral; Methylation; Nucleic Acid Hybridization; Oncogene Proteins, Viral; Promoter Regions, Genetic; RNA, Viral; Transcription, Genetic; Transfection | 1989 |
Pharmacodynamic and DNA methylation studies of high-dose 1-beta-D-arabinofuranosyl cytosine before and after in vivo 5-azacytidine treatment in pediatric patients with refractory acute lymphocytic leukemia.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Arabinofuranosylcytosine Triphosphate; Azacitidine; Child; Child, Preschool; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Resistance; Drug Screening Assays, Antitumor; Female; Gene Expression Regulation; Humans; Male; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Remission Induction; Tumor Cells, Cultured | 1989 |
Effect of 5-azacytidine on gene expression in marrow stromal cells.
Topics: Azacitidine; Blotting, Northern; Bone Marrow; Cells, Cultured; Collagen; DNA; DNA Probes; Humans; Interleukin-1; Interleukin-6; Interleukins; Methylation; Plasmids; Proto-Oncogenes; RNA, Messenger; Time Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1989 |
5-Aza-2'-deoxycytidine as inducer of differentiation and growth inhibition in mouse neuroblastoma cells.
Topics: Acetylcholinesterase; Animals; Azacitidine; Cell Differentiation; Cell Division; Cell Survival; Decitabine; DNA; Methylation; Mice; Neuroblastoma; Tumor Cells, Cultured | 1989 |
Activation and demethylation of the intracisternal A particle genes by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Line; Dealkylation; Decitabine; Gene Expression Regulation; Genes, Intracisternal A-Particle; Methylation; Mice; Microscopy, Electron; Proto-Oncogenes; RNA, Messenger | 1989 |
2-Aminopurine as a probe for mismatch repair in mammalian cells and its relationship to DNA methylation.
Topics: 2-Aminopurine; Adenine; Animals; Azacitidine; Cell Line; Clone Cells; Cricetinae; Cricetulus; Decitabine; DNA; DNA Repair; DNA Replication; Female; Methylation; Molecular Probes; Ovary | 1989 |
Reactivation of hprt on the inactive X chromosome with DNA demethylating agents.
Topics: Animals; Azacitidine; Cell Differentiation; DNA Replication; Dosage Compensation, Genetic; Gene Expression Regulation; Genes; Hot Temperature; Hypoxanthine Phosphoribosyltransferase; Isoelectric Focusing; Methylation; Mice; Protein Denaturation; RNA, Messenger; Tumor Cells, Cultured; X Chromosome | 1989 |
5-azacytidine-induced tumorous transformation and DNA hypomethylation in Nicotiana tissue cultures.
Topics: 5-Methylcytosine; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Cytosine; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Electrophoresis, Agar Gel; Methylation; Plant Tumors; Thymidine; Time Factors | 1989 |
Maintenance of DNA methylation level in SV40-infected human fibroblasts during their in vitro limited proliferative life span.
Topics: 5-Methylcytosine; Azacitidine; Base Composition; Cell Division; Cell Transformation, Viral; Cytosine; Decitabine; DNA; Humans; In Vitro Techniques; Methylation; Simian virus 40 | 1989 |
Mechanism of action of 5-AZA-dC: induced DNA hypomethylation does not lead to aberrant gene expression in human leukemic CEM cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line; Decitabine; DNA Damage; DNA, Neoplasm; Gene Expression; Humans; Kinetics; Methylation; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; RNA, Neoplasm | 1989 |
The role of methylation in the phenotype-dependent modulation of Epstein-Barr nuclear antigen 2 and latent membrane protein genes in cells latently infected with Epstein-Barr virus.
Topics: Antigens, Viral; Azacitidine; Cell Line; DNA Probes; DNA Replication; Enhancer Elements, Genetic; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Genes, Viral; Herpesvirus 4, Human; Humans; Lymphocytes; Membrane Proteins; Methylation; Nasopharyngeal Neoplasms; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Restriction Mapping; Viral Proteins; Viral Structural Proteins | 1989 |
Extensive changes in DNA methylation patterns accompany activation of a silent T-DNA ipt gene in Agrobacterium tumefaciens-transformed plant cells.
Topics: Alkyl and Aryl Transferases; Azacitidine; Cell Line, Transformed; DNA Transposable Elements; DNA, Bacterial; Gene Expression; Methylation; Nicotiana; Phenotype; Plant Tumors; Plants, Toxic; Plasmids; Rhizobium; RNA, Messenger; Transcription, Genetic; Transferases | 1989 |
[Is hypomethylation of cellular DNA a step required in the initiation process of chemical carcinogenesis?].
Topics: Aflatoxin B1; Aflatoxins; Amnion; Azacitidine; Carcinogens; Cells, Cultured; DNA; Epithelial Cells; Ethionine; Humans; Methylation; Methylnitronitrosoguanidine | 1989 |
Cellular metabolism of 1-beta-D-arabinofuranosyl-5-azacytosine and incorporation into DNA and RNA of human lymphoid CEM/0 and CEM/dCk(-) cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Leukemia; Methylation; RNA, Neoplasm; Stereoisomerism; Time Factors; Tritium; Tumor Cells, Cultured | 1989 |
Suppression of prolactin gene expression in GH cells correlates with site-specific DNA methylation.
Topics: Animals; Azacitidine; Blotting, Northern; Blotting, Southern; Deoxyribonuclease I; DNA; Gene Expression Regulation; Growth Hormone; In Vitro Techniques; Methylation; Pituitary Gland; Prolactin; Rats; RNA, Messenger; Tumor Cells, Cultured | 1989 |
5-azacytidine-induced alterations in the GH12C1 cells: effects on cellular morphology, chromosome structure, DNA and protein synthesis.
Topics: Animals; Azacitidine; Chromosomes; DNA; Electrophoresis, Polyacrylamide Gel; Growth Hormone; Methylation; Microscopy, Electron; Nuclear Proteins; Pituitary Neoplasms; Prolactin; Rats; Tumor Cells, Cultured | 1989 |
5-Azacytidine affects the programming of expression of the somatic nucleus of Paramecium.
Topics: Animals; Azacitidine; Cell Nucleus; DNA; Mesoderm; Methylation; Paramecium | 1989 |
5-Azacytidine permits gene activation in a previously noninducible cell type.
Topics: Animals; Antigens, Surface; Azacitidine; Creatine Kinase; DNA; Gene Expression Regulation; Genes; HeLa Cells; Humans; Methylation; Mice; Transcriptional Activation | 1985 |
5-azacytidine potentiates initiation induced by carcinogens in rat liver.
Topics: Animals; Azacitidine; Carcinogens; Cocarcinogenesis; DNA; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Methylation; Rats | 1985 |
Sequential changes in DNA methylation patterns of the rat phosphoenolpyruvate carboxykinase gene during development.
Topics: Age Factors; Animals; Azacitidine; Base Sequence; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction Enzymes; Enzyme Induction; Female; Liver; Male; Methylation; Muscles; Phosphoenolpyruvate Carboxykinase (GTP); Pregnancy; Rats; Rats, Inbred Strains; Spleen | 1985 |
The effect of methionine and 5-azacytidine on fragile X expression.
Topics: Azacitidine; Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; DNA; Dose-Response Relationship, Drug; Female; Humans; Lymphocytes; Male; Methionine; Methylation; X Chromosome | 1985 |
Delayed methylation and the matrix bound DNA methylase.
Topics: Animals; Azacitidine; Binding Sites; Cell Nucleus; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; In Vitro Techniques; L Cells; Methylation; Methyltransferases; Mice; Time Factors | 1985 |
Differential gene activity visualized on sister chromatids after replication in the presence of 5-azacytidine.
Topics: Azacitidine; DNA Replication; DNA, Ribosomal; Gene Expression Regulation; Humans; Lymphocytes; Methylation; Nucleolus Organizer Region | 1985 |
Transfer of human and murine globin-gene sequences into transgenic mice.
Topics: Animals; Azacitidine; Base Sequence; Chromosome Mapping; DNA; Embryo Transfer; Female; Galactokinase; Gene Expression Regulation; Genes; Genetic Engineering; Genetic Markers; Globins; Humans; Male; Methylation; Mice; Microinjections; Pedigree; Plasmids; Pregnancy; Zygote | 1985 |
Activators of protein kinase C and 5-azacytidine induce IL-2 receptor expression on human T lymphocytes.
Topics: Azacitidine; Cells, Cultured; DNA; Enzyme Activation; Humans; Methylation; Phytohemagglutinins; Protein Kinase C; Protein Kinases; Receptors, Immunologic; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1985 |
Reversibility of progression of the transformed phenotype in Ad5-transformed rat embryo cells.
Topics: Adenoviruses, Human; Animals; Azacitidine; Cell Division; Cell Transformation, Viral; Cells, Cultured; DNA, Neoplasm; DNA, Viral; Gene Expression Regulation; Genes, Viral; Methylation; Mice; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Transcription, Genetic | 1985 |
Induction of hepatitis B virus core gene in human cells by cytosine demethylation in the promoter.
Topics: 5-Methylcytosine; Azacitidine; Cytosine; DNA Restriction Enzymes; DNA, Viral; Gene Expression Regulation; Genes, Viral; Hepatitis B Core Antigens; Humans; Methylation; Promoter Regions, Genetic; Time Factors; Transcription, Genetic; Virus Replication | 1985 |
Nuclear matrix-associated DNA methylase.
Topics: Ammonium Sulfate; Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Krebs 2; Cell Nucleus; Decitabine; DNA (Cytosine-5-)-Methyltransferases; Kinetics; L Cells; Methylation; Methyltransferases; Mice; Solubility | 1985 |
Reactivation and mutagenesis of herpes virus in 5-azacytidine-treated monkey kidney cells.
Topics: Animals; Azacitidine; Cells, Cultured; Chlorocebus aethiops; DNA, Viral; Methylation; Mutation; Simian virus 40; Simplexvirus; Ultraviolet Rays | 1985 |
Comparison of the antileukemic activity of 5-AZA-2'-deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-azacytidine against L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cytarabine; Decitabine; DNA, Neoplasm; Leukemia L1210; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 1984 |
Changes in T-DNA methylation and expression are associated with phenotypic variation and plant regeneration in a crown gall tumor line.
Topics: Azacitidine; Cell Line; DNA; Gene Expression Regulation; Genetic Variation; Meiosis; Methylation; Phenotype; Plant Tumors; Recombination, Genetic; Rhizobium | 1984 |
SCE and DNA methylation.
Topics: 5-Methylcytosine; Animals; Azacitidine; Benzamides; Cell Line; Cricetinae; Cricetulus; Cytosine; Deer; DNA; DNA Replication; Female; Fibroblasts; Male; Methylation; Mitomycin; Mitomycins; Models, Genetic; Sister Chromatid Exchange | 1984 |
Regulation of intracisternal A particles in mouse teratocarcinoma cells: involvement of DNA methylation in transcriptional control.
Topics: Animals; Azacitidine; Cell Differentiation; Cytarabine; DNA, Viral; Gene Expression Regulation; Inclusion Bodies, Viral; Methylation; Mice; RNA, Viral; Teratoma | 1984 |
The effect of 5-azacytidine and dihydro-5-azacytidine on nuclear ribosomal RNA and poly(A) RNA synthesis in L1210 cells in vitro.
Topics: Adenosine; Animals; Azacitidine; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Leukemia L1210; Methionine; Methylation; Mice; Poly A; RNA; RNA, Heterogeneous Nuclear; RNA, Messenger; RNA, Ribosomal; Uridine | 1980 |
Cellular differentiation, cytidine analogs and DNA methylation.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Differentiation; Cells, Cultured; Cytarabine; Cytidine; Decitabine; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methyltransferases; Mice; Muscles; Structure-Activity Relationship | 1980 |
The comparative effects of 5-azacytidine and dihydro-5-azacytidine on 4 S and 5 S nuclear RNA.
Topics: Animals; Azacitidine; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Leukemia L1210; Methylation; Mice; Molecular Weight; RNA, Neoplasm | 1980 |
Reactivation of an inactive human X chromosome: evidence for X inactivation by DNA methylation.
Topics: Animals; Azacitidine; Base Sequence; Cell Differentiation; DNA; Female; Gene Expression Regulation; Glucosephosphate Dehydrogenase; Humans; Hybrid Cells; Hypoxanthine Phosphoribosyltransferase; Methylation; Mice; Sex Chromosomes; X Chromosome | 1981 |
Chromatin structure of endogenous retroviral genes and activation by an inhibitor of DNA methylation.
Topics: Animals; Azacitidine; Cell Transformation, Viral; Chick Embryo; Chromatin; Deoxyribonuclease I; Deoxyribonucleases; DNA; DNA Restriction Enzymes; Endonucleases; Methylation; Retroviridae; Transcription, Genetic | 1981 |
DNA methylation controls the inducibility of the mouse metallothionein-I gene lymphoid cells.
Topics: Animals; Azacitidine; Cadmium; Cell Line; Dexamethasone; DNA; Gene Expression Regulation; Metalloproteins; Metallothionein; Methylation; Mice; RNA, Messenger; Thymoma; Transcriptional Activation | 1981 |
Studies of X chromosome DNA methylation in normal human cells.
Topics: Azacitidine; Cell Division; Cells, Cultured; DNA; DNA Restriction Enzymes; Female; Gene Expression Regulation; Humans; Hybrid Cells; Methylation; Placenta; Plasmids; Sex Chromosomes; X Chromosome | 1982 |
5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene.
Topics: Azacitidine; Cell Transformation, Viral; DNA; Gene Expression Regulation; Genes, Viral; Methylation; Simplexvirus; Thymidine Kinase | 1982 |
Cell cycle-specific reactivation of an inactive X-chromosome locus by 5-azadeoxycytidine.
Topics: Animals; Azacitidine; Cell Division; Decitabine; DNA; Female; Genes; Humans; Hybrid Cells; Hypoxanthine Phosphoribosyltransferase; Interphase; Methylation; Mice; Sex Chromosomes; X Chromosome | 1982 |
Induction of prolactin-deficient variants of GH3 rat pituitary tumor cells by ethyl methanesulfonate: reversion by 5-azacytidine, a DNA methylation inhibitor.
Topics: Animals; Azacitidine; Cell Line; Ethyl Methanesulfonate; Gene Expression Regulation; Methylation; Mutation; Phenotype; Pituitary Neoplasms; Prolactin; Rats; Ultraviolet Rays | 1982 |
The effect of 5-azadeoxycytidine on cell growth and DNA methylation.
Topics: Animals; Azacitidine; Cell Division; Cell Line; Cricetinae; Decitabine; DNA Replication; Methylation; Mice; Time Factors | 1982 |
Analogues of 5-methyl cytosine and early embryonic development.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cytosine; DNA; Embryo, Nonmammalian; Gene Expression Regulation; Methylation; Sea Urchins | 1982 |
Induction of thymidine kinase in enzyme-deficient Chinese hamster cells.
Topics: Animals; Azacitidine; Butyrates; Cell Differentiation; Cells, Cultured; Cricetinae; Cricetulus; DNA; Enzyme Induction; Ethionine; Ethyl Methanesulfonate; Gene Expression Regulation; Methylation; Thymidine Kinase | 1982 |
5-azacytidine-induced re-expression of alleles on the inactive X chromosome in a hybrid mouse cell line.
Topics: Alleles; Animals; Azacitidine; DNA; Dosage Compensation, Genetic; Female; Hybrid Cells; Hypoxanthine Phosphoribosyltransferase; Isoenzymes; Methylation; Mice; Muridae; Phosphoglycerate Kinase; Sex Chromosomes; X Chromosome | 1982 |
5-Azacytidine stimulates fetal hemoglobin synthesis in anemic baboons.
Topics: Animals; Azacitidine; Fetal Hemoglobin; Gene Expression Regulation; Globins; Hematopoiesis; Hemoglobin A; Hydroxyurea; Methylation; Papio | 1982 |
DNA methylation affecting the expression of murine leukemia proviruses.
Topics: 5-Methylcytosine; AKR murine leukemia virus; Animals; Azacitidine; Cell Line; Cloning, Molecular; Cytosine; DNA Restriction Enzymes; DNA, Viral; Gene Expression Regulation; Genes, Viral; Leukemia Virus, Murine; Methylation; Mice; Moloney murine leukemia virus; Rats; Recombination, Genetic; Transfection | 1982 |
5-azacytidine selectively increases gamma-globin synthesis in a patient with beta+ thalassemia.
Topics: Adult; Azacitidine; DNA; Erythropoiesis; Gene Expression Regulation; Globins; Hemoglobins; Humans; Male; Methylation; RNA, Messenger; Stimulation, Chemical; Thalassemia | 1982 |
Clinical management of gene expression.
Topics: Azacitidine; DNA; Fetal Hemoglobin; Gene Expression Regulation; Globins; Humans; Methylation; Thalassemia | 1982 |
Expression of transferred thymidine kinase genes is controlled by methylation.
Topics: Animals; Azacitidine; Gene Expression Regulation; Genes; Genes, Viral; Genetic Linkage; L Cells; Methylation; Mice; Simplexvirus; Thymidine Kinase | 1982 |
Effect of 5-azacytidine on differentiation and DNA methylation in human promyelocytic leukemia cells (HL-60).
Topics: Azacitidine; Cell Differentiation; Cell Line; Clone Cells; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Humans; Leukemia, Myeloid, Acute; Methylation; Methyltransferases; Superoxides; Tetradecanoylphorbol Acetate | 1983 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin | 1983 |
The effect of 5-azacytidine on mammary gland differentiation in vitro.
Topics: Animals; Azacitidine; Cell Differentiation; Female; Lactation; Mammary Glands, Animal; Methylation; Mice; Mice, Inbred C3H; Pregnancy; Prolactin | 1983 |
Mechanism of action of eukaryotic DNA methyltransferase. Use of 5-azacytosine-containing DNA.
Topics: Animals; Azacitidine; Cells, Cultured; Cytidine; DNA (Cytosine-5-)-Methyltransferases; DNA, Single-Stranded; Methylation; Methyltransferases; Mice; Osmolar Concentration | 1982 |
Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells.
Topics: Animals; Azacitidine; Bromodeoxyuridine; Cell Cycle; Cell Differentiation; Cell Line; DNA, Viral; Gene Expression Regulation; Genes, Viral; Methylation; Mice; Moloney murine leukemia virus; Recombination, Genetic; Teratoma; Transcription, Genetic; Transfection; Tretinoin | 1983 |
Emv-13 (Akv-3): a noninducible endogenous ecotropic provirus of AKR/J mice.
Topics: Animals; Antigens, Viral; Azacitidine; Cells, Cultured; DNA, Viral; Genes, Viral; Idoxuridine; Leukemia Virus, Murine; Methylation; Mice; Mice, Inbred AKR; Recombination, Genetic; RNA, Viral; Virus Activation | 1983 |
Inhibition of DNA methylation by 5-azacytidine.
Topics: Animals; Azacitidine; Cell Differentiation; Cells, Cultured; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methyltransferases; Mice; Mice, Inbred C3H | 1983 |
Specific effects of 5-fluoropyrimidines and 5-azapyrimidines on modification of the 5 position of pyrimidines, in particular the synthesis of 5-methyluracil and 5-methylcytosine in nucleic acids.
Topics: 5-Methylcytosine; Animals; Azacitidine; Cytidine; Cytosine; DNA; Liver; Methylation; Mice; Pyrimidines; RNA, Transfer; Thymine | 1983 |
Transcriptional activation of endogenous rat retrovirus with and without hypomethylation of proviral DNA.
Topics: Animals; Azacitidine; Bromodeoxyuridine; DNA Replication; DNA, Viral; Fibroblasts; Gene Expression Regulation; Methylation; Rats; Retroviridae; Transcription, Genetic; Virus Activation; Virus Cultivation | 1983 |
Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action.
Topics: 5-Methylcytosine; Animals; Antineoplastic Agents; Azacitidine; Cytosine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; Dose-Response Relationship, Drug; Leukemia L1210; Male; Methylation; Mice | 1983 |
DNA methylation and the control of gene expression on the human X chromosome.
Topics: Animals; Azacitidine; Cell Line; Chromosome Banding; Cricetinae; Cricetulus; DNA; DNA Replication; Female; Genes; Humans; Hybrid Cells; Methylation; Mice; Sex Chromosomes; X Chromosome | 1983 |
Activation of human ribosomal genes by 5-azacytidine.
Topics: Azacitidine; DNA; Fibroblasts; Gene Expression Regulation; Humans; Methylation; Nucleolus Organizer Region; RNA, Ribosomal | 1983 |
Effect of 5-azacytidine treatment on mouse embryonal carcinoma cells.
Topics: Animals; Antigens, Viral; Antigens, Viral, Tumor; Azacitidine; Cell Differentiation; Cell Line; Cytoskeleton; DNA Replication; H-2 Antigens; Methylation; Mice; Plasminogen Activators; Polyomavirus; Simian virus 40; Teratoma; Virus Replication | 1983 |
Incorporation of 5-Aza-2'-deoxycytidine-5'-triphosphate into DNA. Interactions with mammalian DNA polymerase alpha and DNA methylase.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cattle; Cytidine Triphosphate; Cytosine Nucleotides; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Polymerase II; DNA-Directed DNA Polymerase; Kinetics; Methylation; Methyltransferases; Mice; Templates, Genetic | 1983 |
Induction of chromosome decondensation, sister-chromatid exchanges and endoreduplications by 5-azacytidine, an inhibitor of DNA methylation.
Topics: Animals; Azacitidine; Cell Line; Chromosomes; Cricetinae; Cricetulus; Crossing Over, Genetic; Dipodomys; DNA; DNA Replication; Female; Heterochromatin; Humans; Lymphocytes; Methylation; Ovary; Sister Chromatid Exchange | 1983 |
5-Azacytidine increases gamma-globin synthesis and reduces the proportion of dense cells in patients with sickle cell anemia.
Topics: Adult; Anemia, Sickle Cell; Azacitidine; Bone Marrow Cells; DNA; Erythrocytes; Fetal Hemoglobin; Globins; Humans; Male; Methylation; Middle Aged; RNA, Messenger; Thalassemia | 1983 |
Treatment of sickle cell anemia with 5-azacytidine results in increased fetal hemoglobin production and is associated with nonrandom hypomethylation of DNA around the gamma-delta-beta-globin gene complex.
Topics: Adult; Anemia, Sickle Cell; Azacitidine; DNA; DNA Restriction Enzymes; Fetal Hemoglobin; Genes; Globins; Humans; Male; Methylation; Nucleic Acid Hybridization | 1983 |
Activation of intracisternal a particles by 5-azacytidine in mouse Ki-BALB cell line.
Topics: Animals; Azacitidine; Cell Line; Cell Transformation, Viral; DNA, Viral; Dose-Response Relationship, Drug; Idoxuridine; Kirsten murine sarcoma virus; Methylation; Mice; Retroviridae; Time Factors; Virus Activation | 1983 |
Azacytidine-induced tumorigenesis of CHEF/18 cells: correlated DNA methylation and chromosome changes.
Topics: Adipose Tissue; Animals; Azacitidine; Cell Line; Chromosome Aberrations; Chromosome Disorders; Cricetinae; DNA, Neoplasm; Karyotyping; Methylation; Mice; Mice, Nude; Neoplasms, Experimental; Trisomy | 1983 |
Fragile X expression is decreased by 5-azacytidine and S-adenosylhomocysteine.
Topics: Azacitidine; Cell Line; Culture Media; DNA; Dose-Response Relationship, Drug; Floxuridine; Fragile X Syndrome; Homocysteine; Humans; Karyotyping; Methionine; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Sex Chromosome Aberrations | 1983 |
Developmental activation of the H-2K gene is correlated with an increase in DNA methylation.
Topics: Animals; Azacitidine; Cell Line; DNA Restriction Enzymes; DNA, Neoplasm; Epidermal Growth Factor; ErbB Receptors; Genes; H-2 Antigens; Major Histocompatibility Complex; Methylation; Mice; Nucleic Acid Hybridization; Poly A; Receptors, Cell Surface; RNA; RNA, Messenger; Teratoma | 1983 |
High-frequency conversion to a "fluffy" developmental phenotype in Aspergillus spp. by 5-azacytidine treatment: evidence for involvement of a single nuclear gene.
Topics: Aspergillus nidulans; Aspergillus niger; Azacitidine; DNA, Fungal; Genes, Fungal; Genotype; Kinetics; Methylation; Phenotype; Species Specificity | 1983 |
Globin gene studies create a puzzle.
Topics: Anemia, Sickle Cell; Azacitidine; Cell Differentiation; Cytarabine; DNA; Erythropoiesis; Fetal Hemoglobin; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Hydroxyurea; Interphase; Methylation | 1984 |
5-azacytidine induction of thymidine kinase in a spontaneously enzyme-deficient murine tumor line.
Topics: Animals; Azacitidine; Cell Division; Cell Line; DNA, Neoplasm; Enzyme Induction; Methylation; Mice; Neoplasms, Experimental; Thymidine Kinase | 1984 |
The role of cytosine methylation in the control of nopaline synthase gene expression in a plant tumor.
Topics: Amino Acid Oxidoreductases; Azacitidine; Cytosine; DNA; DNA, Neoplasm; Gene Expression Regulation; Malate Dehydrogenase; Methylation; Plant Tumors; Rhizobium | 1983 |
DNA methylation and globin gene expression in patients treated with 5-azacytidine.
Topics: Azacitidine; DNA (Cytosine-5-)-Methyltransferases; Fetal Hemoglobin; Gene Expression Regulation; Genes; Globins; Humans; Methylation | 1983 |
5-Azacytidine increases fetal hemoglobin production in a patient with sickle cell disease.
Topics: Adult; Anemia, Sickle Cell; Azacitidine; DNA (Cytosine-5-)-Methyltransferases; Fetal Hemoglobin; Gene Expression Regulation; Globins; Hemoglobin, Sickle; Humans; Male; Methylation | 1983 |
Fetal hemoglobin production in adult baboons by 5-azacytidine or by phenylhydrazine-induced hemolysis is associated with hypomethylation of globin gene DNA.
Topics: Animals; Azacitidine; Fetal Hemoglobin; Gene Expression Regulation; Genes; Globins; Hemolysis; Methylation; Papio; Phenylhydrazines; Time Factors | 1983 |
In vivo demethylation of chicken embryonic beta-type globin genes with 5-azacytidine.
Topics: Animals; Azacitidine; Chickens; Gene Expression Regulation; Genes; Globins; Methylation; Transcription, Genetic; Transcriptional Activation | 1983 |
Augmentation of fetal-hemoglobin production in anemic monkeys by hydroxyurea.
Topics: Anemia; Animals; Azacitidine; Bloodletting; DNA; Erythrocyte Count; Fetal Hemoglobin; Globins; Hydroxyurea; Macaca fascicularis; Methylation; Transcription, Genetic | 1984 |
Hemoglobin--from F to A, and back.
Topics: Anemia, Sickle Cell; Azacitidine; DNA; Fetal Hemoglobin; Humans; Hydroxyurea; Methylation; Thalassemia | 1984 |
5-aza-2'-deoxycytidine therapy in patients with acute leukemia inhibits DNA methylation.
Topics: Azacitidine; Cell Line; Decitabine; DNA, Neoplasm; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methylation | 1984 |
Effects of 5-azacytidine on methylation and expression of specific DNA sequences in C3H 10T1/2 cells.
Topics: Animals; Azacitidine; Cell Line; Clone Cells; Gene Expression Regulation; Globins; Methylation; Mice; Mice, Inbred C3H; Oncogenes | 1984 |
Spontaneous and 5-azacytidine-induced reexpression of ornithine carbamoyl transferase in hepatoma cells.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Gene Expression Regulation; Liver; Liver Neoplasms, Experimental; Methylation; Ornithine Carbamoyltransferase; Rats | 1984 |
Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity.
Topics: Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; DNA, Neoplasm; Methylation; Mice; Neoplasm Metastasis; Neoplasms, Experimental | 1984 |
The persistence of maternal inheritance in Chlamydomonas despite hypomethylation of chloroplast DNA induced by inhibitors.
Topics: Azacitidine; Chlamydomonas; Chloroplasts; Ethionine; Extrachromosomal Inheritance; Methylation | 1984 |
Reversal of DNA methylation with 5-azacytidine alters chromosome replication patterns in human lymphocyte and fibroblast cultures.
Topics: Azacitidine; Cell Division; Cells, Cultured; Chromosome Banding; Chromosomes; DNA Replication; Female; Fibroblasts; Gene Expression Regulation; Humans; Lymphocytes; Male; Methylation; Transcriptional Activation | 1984 |
Inhibition of polyoma gene expression in transformed mouse cells by hypermethylation.
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Neoplastic; Cells, Cultured; Cloning, Molecular; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Methylation; Mice; Mice, Inbred Strains; Mutation; Nucleic Acid Hybridization; Plasmids; Polyomavirus | 1984 |
Epsilon-globin gene is undermethylated in K-562 cells: increased expression after treatment of the cells with 5-azacytidine.
Topics: Azacitidine; Cell Line; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; DNA, Recombinant; Gene Expression Regulation; Globins; Humans; Leukemia; Methylation; Nucleic Acid Hybridization; RNA, Messenger | 1984 |
Analysis of the variations in proviral cytosine methylation that accompany transformation and morphological reversion in a line of Rous sarcoma virus-infected Rat-1 cells.
Topics: 5-Methylcytosine; Animals; Avian Sarcoma Viruses; Azacitidine; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Cytosine; DNA Restriction Enzymes; DNA, Viral; Methylation; Rats; Transcription, Genetic | 1984 |
Effect of 5-azacytidine on deoxyribonucleic acid methylation in Escherichia coli K12.
Topics: Azacitidine; Bacterial Proteins; beta-Galactosidase; DNA, Bacterial; Escherichia coli; Methylation; Methyltransferases | 1984 |
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs.
Topics: Azacitidine; Deoxycytidine; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methyltransferases | 1983 |
Human leukemia K-562 cells: induction of erythroid differentiation by 5-azacytidine.
Topics: Azacitidine; Cell Differentiation; Cell Line; Deoxyribonuclease HpaII; DNA; DNA Restriction Enzymes; Erythrocytes; Fetal Hemoglobin; Gene Expression Regulation; Globins; Hemoglobins; Hemoglobins, Abnormal; Humans; Leukemia, Erythroblastic, Acute; Methylation; RNA, Messenger | 1984 |
The effects of 5-azacytidine on the expression of the rat growth hormone gene. Methylation modulates but does not control growth hormone gene activity.
Topics: Adrenocorticotropic Hormone; Animals; Azacitidine; Cell Line; DNA; Gene Expression Regulation; Growth Hormone; Liver Neoplasms, Experimental; Methylation; Mice; Nucleic Acid Precursors; Pituitary Neoplasms; Prolactin; Rats; RNA Precursors; RNA, Messenger | 1984 |
1-beta-D-arabinosyl-5-azacytosine. Cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells.
Topics: Azacitidine; Cell Line; Cell Survival; Colonic Neoplasms; DNA, Neoplasm; Humans; Kinetics; Methylation; Stereoisomerism | 1984 |
Effect of 5-azacytidine on DNA methylation and on the enzymes of de novo pyrimidine biosynthesis in Bacillus subtilis Marburg strain.
Topics: Azacitidine; Bacillus subtilis; Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Paper; DNA (Cytosine-5-)-Methyltransferases; DNA, Bacterial; Methylation; Orotate Phosphoribosyltransferase; Pentosyltransferases; Phosphorylation; Pyrimidines; Uridine Kinase | 1984 |
Long term instability and molecular mechanism of 5-azacytidine-induced DNA hypomethylation in normal and neoplastic tissues in vivo.
Topics: Animals; Azacitidine; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Kinetics; Leukemia L1210; Liver; Liver Regeneration; Male; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 1984 |
DNA methylation and regulation of the human beta-globin-like genes in mouse erythroleukemia cells containing human chromosome 11.
Topics: Acetamides; Animals; Azacitidine; Cell Line; Chromosomes, Human, 6-12 and X; DNA; Gene Expression Regulation; Globins; Humans; Hybrid Cells; Leukemia, Erythroblastic, Acute; Methylation; Mice; RNA, Messenger | 1984 |
[DNA methylation and control of gene expression].
Topics: Animals; Azacitidine; Base Sequence; Cell Transformation, Viral; Chromosomes; DNA; DNA Replication; Gene Expression Regulation; Humans; Methylation | 1984 |
Is increase of fetal hemoglobin due to erythropoietic stress the result of DNA hypomethylation?
Topics: Anemia, Hemolytic; Animals; Azacitidine; Base Sequence; Bone Marrow; DNA; Erythropoiesis; Fetal Hemoglobin; Methylation; Nucleic Acid Hybridization; Papio; Phenylhydrazines | 1983 |
The role of DNA methylation in virus replication: inhibition of frog virus 3 replication by 5-azacytidine.
Topics: Animals; Azacitidine; Cells, Cultured; DNA Replication; DNA Restriction Enzymes; Fishes; Iridoviridae; Kinetics; Methylation; Microscopy, Electron; Vaccinia virus; Virus Replication | 1984 |
Human leukemic K562 cells: differential effects of 5-azacytidine on DNA methylation of epsilon-, gamma-globin and 7SL RNA genes.
Topics: Azacitidine; Base Sequence; Cell Line; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Restriction Enzymes; Electrophoresis, Cellulose Acetate; Globins; Humans; Leukemia; Methylation; RNA | 1984 |
The tumorigenicity of 5-azacytidine in the male Fischer rat.
Topics: Animals; Azacitidine; DNA; Kidney Neoplasms; Leukemia, Experimental; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphatic Diseases; Male; Methylation; Neoplasms, Experimental; Rats; Rats, Inbred F344; Skin Neoplasms; Testicular Neoplasms | 1984 |
DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells.
Topics: Animals; Azacitidine; Cell Line; Cytosine; Decitabine; DNA; Drug Resistance; Kinetics; Methylation; Mice; Mice, Inbred C3H | 1984 |
Induction of a step in carcinogenesis that is normally associated with mutagenesis by nonmutagenic concentrations of 5-azacytidine.
Topics: Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Clone Cells; Cricetinae; DNA; Kidney; Methylation; Mutagenicity Tests; Mutagens; Mutation | 1984 |
Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA.
Topics: 5-Methylcytosine; Adenoma; Animals; Azacitidine; Base Sequence; Cell Line; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Neoplasm; Methylation; Oligodeoxyribonucleotides; Oligonucleotides; Pituitary Neoplasms; Rats; Substrate Specificity | 1984 |
DNA methylation and expression of baboon globin genes.
Topics: Animals; Azacitidine; Base Sequence; DNA; DNA Restriction Enzymes; Gene Expression Regulation; Globins; Hematopoietic Stem Cells; Hemoglobins; Methylation; Papio; Phenylhydrazines | 1984 |
Evidence for gene silencing by DNA methylation in normal human diploid fibroblasts.
Topics: Azacitidine; Cell Line; Deoxycytosine Nucleotides; Diploidy; DNA; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Linkage; Humans; Hypoxanthine Phosphoribosyltransferase; Male; Methylation; X Chromosome | 1995 |
Abnormal chromosome behavior in Neurospora mutants defective in DNA methylation.
Topics: 5-Methylcytosine; Aneuploidy; Azacitidine; Blotting, Southern; Chromosomes, Fungal; Crosses, Genetic; Cytosine; DNA, Fungal; Genes, Fungal; Genetic Complementation Test; Methionine; Methylation; Mutation; Neurospora crassa; Phenotype; S-Adenosylmethionine | 1993 |
Induction of cholinergic and adrenergic differentiation in N-18 cells by differentiation agents and DNA demethylating agents.
Topics: Acetylcholine; Antineoplastic Agents; Azacitidine; Cell Differentiation; Choline O-Acetyltransferase; Culture Media, Conditioned; Decitabine; DNA, Neoplasm; Methylation; Neurons; RNA, Messenger; Sympathetic Nervous System; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1993 |
Antiproliferative effects and DNA hypomethylation by 5-aza-2'-deoxycytidine in human neuroblastoma cell lines.
Topics: Antigens, Differentiation; Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Division; Decitabine; Deoxycytidine; Deoxycytidine Kinase; DNA-Cytosine Methylases; DNA, Neoplasm; Humans; Methylation; Neuroblastoma; Tumor Cells, Cultured | 1993 |
Exemption of satellite DNA from demethylation in immortalized differentiated derivatives of F9 mouse embryonal carcinoma cells.
Topics: Animals; Antineoplastic Agents; Azacitidine; Carcinoma, Embryonal; Cell Differentiation; Cell Division; Cell Line; Cell Line, Transformed; Collagen; Decitabine; DNA, Neoplasm; DNA, Satellite; Embryo, Mammalian; Endoderm; Glyceraldehyde-3-Phosphate Dehydrogenases; Kinetics; Methylation; Mice; Pseudogenes; Repetitive Sequences, Nucleic Acid; Restriction Mapping; RNA, Messenger; Stem Cells; Tumor Cells, Cultured | 1994 |
[The effect of thyroid hormones and 5-azacytidine on the gene transcription of malic enzyme and 6-phosphogluconate dehydrogenase].
Topics: Animals; Azacitidine; Depression, Chemical; DNA; Gene Expression Regulation, Enzymologic; Malate Dehydrogenase; Male; Methylation; Phosphogluconate Dehydrogenase; Rats; Rats, Wistar; Thyroid Hormones; Transcription, Genetic | 1993 |
Regulation of folate-binding protein gene expression by DNA methylation in methotrexate-resistant KB cells.
Topics: Azacitidine; Blotting, Southern; Carrier Proteins; Decitabine; DNA, Neoplasm; Drug Resistance; Folate Receptors, GPI-Anchored; Gene Expression Regulation, Neoplastic; Humans; KB Cells; Methotrexate; Methylation; Receptors, Cell Surface; Transcription, Genetic | 1994 |
Alu transcripts: cytoplasmic localisation and regulation by DNA methylation.
Topics: Azacitidine; Base Sequence; Blotting, Northern; Cell Fractionation; Centrifugation, Density Gradient; Cytoplasm; DNA; DNA, Complementary; HeLa Cells; Humans; Methylation; Molecular Sequence Data; Repetitive Sequences, Nucleic Acid; Ribonucleoproteins; Ribosomes; RNA; RNA Polymerase III; RNA, Messenger | 1994 |
De novo methylation of an MHC class I transgene following transformation with human adenoviruses is not correlated with its altered expression.
Topics: Adenoviridae; Animals; Azacitidine; Cell Line; Cell Membrane; Cell Transformation, Viral; DNA; Gene Expression Regulation, Viral; Genes, MHC Class I; Histocompatibility Antigens Class I; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Swine; Swine, Miniature | 1994 |
S-adenosyl-L-homocysteine: a non-cytotoxic hypomethylating agent.
Topics: Azacitidine; Cell Membrane Permeability; Cells, Cultured; Decitabine; DNA; DNA Modification Methylases; DNA Replication; Fibroblasts; Humans; L-Lactate Dehydrogenase; Methylation; Mitochondria; S-Adenosylhomocysteine; Tetrazolium Salts | 1994 |
Dependence of transcriptional repression on CpG methylation density.
Topics: 5-Methylcytosine; Azacitidine; Butyrates; Cell Nucleus; Cytosine; DNA-Cytosine Methylases; Gene Expression Regulation; Methylation; Transcription, Genetic; Transfection | 1994 |
Structure and organization of a stable extrachromosomal element in human cells.
Topics: Azacitidine; DNA; Electrophoresis, Gel, Pulsed-Field; Extrachromosomal Inheritance; Gene Amplification; HeLa Cells; Humans; Methylation; Nucleic Acid Conformation; Restriction Mapping; Tetrahydrofolate Dehydrogenase; Transfection | 1994 |
Macronuclear DNA demethylation is involved in the encystment process of the ciliate Colpoda inflata.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Nucleus; DNA, Protozoan; Gene Expression; Methylation; Restriction Mapping; Trichostomatida | 1994 |
Non-hormonal factors on differentiation of bovine mammary cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amino Acids; Animals; Azacitidine; Cattle; Cell Differentiation; Cells, Cultured; Cyclic AMP; DNA; Enzyme Activation; Female; Mammary Glands, Animal; Methylation; Pregnancy; Protein Biosynthesis; Spermidine | 1994 |
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.
Topics: Animals; Azacitidine; Base Sequence; Deoxyribonucleoproteins; DNA-Binding Proteins; Gene Expression Regulation; Genes; Interferon-gamma; Methylation; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymorphism, Restriction Fragment Length; Regulatory Sequences, Nucleic Acid; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells | 1994 |
Lymphocyte function-associated antigen 1 overexpression and T cell autoreactivity.
Topics: Azacitidine; CD18 Antigens; DNA; DNA, Complementary; Humans; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Methylation; Plasmids; Procainamide; T-Lymphocytes; Transfection; Ultraviolet Rays | 1994 |
Activation of the galectin-1 (L-14-I) gene from nonexpressing differentiated cells by fusion with undifferentiated and tumorigenic cells.
Topics: Alleles; Animals; Azacitidine; Base Sequence; Cell Differentiation; Cell Fusion; Cells, Cultured; Galectin 1; Gene Expression Regulation, Neoplastic; Genes, Dominant; Hemagglutinins; Humans; Liver; Liver Neoplasms, Experimental; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplastic Stem Cells; Osteosarcoma; Rats; Tumor Cells, Cultured | 1994 |
Sequence-specific hypomethylation of the tobacco genome induced with dihydroxypropyladenine, ethionine and 5-azacytidine.
Topics: Adenine; Adenosylhomocysteinase; Azacitidine; Cells, Cultured; Deoxyribonucleases, Type II Site-Specific; DNA-Cytosine Methylases; DNA, Plant; Ethionine; Genome, Plant; Hydrolases; Methylation; Nicotiana; Plants, Toxic | 1994 |
Amyloid precursor protein gene expression in neural cell lines: influence of DNA cytosine methylation.
Topics: Amyloid beta-Protein Precursor; Animals; Azacitidine; Cell Line; Cytosine; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Neoplastic; Methylation; Mice; Neuroblastoma; Restriction Mapping; RNA, Messenger; RNA, Ribosomal, 28S | 1994 |
Demethylation in the 5'-flanking region of mouse cellular retinoic acid binding protein-I gene is associated with its high level of expression in mouse embryos and facilitates its induction by retinoic acid in P19 embryonal carcinoma cells.
Topics: Animals; Azacitidine; Base Sequence; Carcinoma, Embryonal; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; Embryonic and Fetal Development; Gene Expression Regulation, Developmental; Methylation; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Retinoic Acid; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 1994 |
An extra band within the human 9qh+ region that behaves like the surrounding constitutive heterochromatin.
Topics: 5-Methylcytosine; Adult; Azacitidine; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human; Chromosomes, Human, Pair 9; Cytosine; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Lymphocytes; Male; Methylation; Microscopy, Electron | 1994 |
Expression of cyclin D2 in Epstein-Barr virus-positive Burkitt's lymphoma cell lines is related to methylation status of the gene.
Topics: Antigens, Viral; Azacitidine; Base Sequence; Burkitt Lymphoma; Cyclin D2; Cyclins; DNA-Binding Proteins; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation; Herpesvirus 4, Human; Humans; Methylation; Molecular Sequence Data; Tumor Cells, Cultured | 1995 |
Role of methylation in placental major histocompatibility complex antigen expression and fetal loss.
Topics: Animals; Azacitidine; DNA; Female; Fetal Death; Gene Expression; Genes, MHC Class I; Genes, MHC Class II; Genomic Imprinting; Histocompatibility Antigens Class I; Histocompatibility Antigens Class II; Immunohistochemistry; Major Histocompatibility Complex; Methylation; Nucleic Acid Hybridization; Placenta; Pregnancy; Rats; Rats, Inbred WF; Specific Pathogen-Free Organisms | 1994 |
HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Cytarabine; DNA; Fluorouracil; HIV-1; Methotrexate; Methylation; Molecular Sequence Data; NF-kappa B; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Vinblastine | 1995 |
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
Topics: Animals; Autoantibodies; Azacitidine; Cell Line; Cytokines; Cytotoxicity, Immunologic; DNA; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Immunoglobulin M; Immunotherapy, Adoptive; Lupus Erythematosus, Systemic; Lymphocyte Activation; Methylation; Mice; Mice, Inbred AKR; Mice, Inbred NZB; Procainamide; Th2 Cells | 1995 |
Pharmacologic activation of expression of immunodominant viral antigens: a new strategy for the treatment of Epstein-Barr-virus-associated malignancies.
Topics: Adult; Antigens, Viral; Azacitidine; Base Sequence; Burkitt Lymphoma; Decitabine; DNA-Binding Proteins; DNA, Neoplasm; DNA, Viral; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesviridae Infections; Herpesvirus 4, Human; Humans; Immunodominant Epitopes; Lymphoma, B-Cell; Methylation; Molecular Sequence Data; Polymerase Chain Reaction; Tumor Cells, Cultured; Tumor Virus Infections; Viral Matrix Proteins; Virus Activation | 1995 |
Transcriptional regulation of the mts1 gene in human lymphoma cells: the role of DNA-methylation.
Topics: Azacitidine; Decitabine; DNA Modification Methylases; Gene Expression Regulation; Humans; Lymphoma; Methylation; Neoplasm Metastasis; Restriction Mapping; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
The mechanism of inhibition of DNA (cytosine-5-)-methyltransferases by 5-azacytosine is likely to involve methyl transfer to the inhibitor.
Topics: Azacitidine; Base Sequence; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; Escherichia coli; Hot Temperature; Methylation; Models, Chemical; Molecular Sequence Data; Oligonucleotides; S-Adenosylmethionine; Sodium Dodecyl Sulfate | 1995 |
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens.
Topics: Animals; Azacitidine; Base Sequence; Carcinogens; Cell Line; Chromatin; Cricetinae; Cricetulus; DNA; DNA Primers; Drug Resistance; Gene Expression; Genetic Variation; Hypoxanthine Phosphoribosyltransferase; Methylation; Models, Biological; Molecular Sequence Data; Nickel; Phenotype; Thioguanine | 1995 |
[Characterization of chromosomal rearrangements by in situ hybridization in glioblastoma].
Topics: Azacitidine; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; DNA, Neoplasm; DNA, Satellite; Glioblastoma; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Male; Methylation; Middle Aged; Tumor Cells, Cultured | 1994 |
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; Breast Neoplasms; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression; Gene Expression Regulation, Neoplastic; Guanine; Humans; Methylation; Molecular Sequence Data; Receptors, Estrogen; RNA, Messenger; Tumor Cells, Cultured | 1995 |
CpG methylation represses the activity of the rat prolactin promoter in rat GH3 pituitary cell lines.
Topics: Animals; Azacitidine; Base Sequence; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; DNA; DNA-Binding Proteins; Gene Expression Regulation; Methylation; Molecular Sequence Data; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Rats; Transcription Factor Pit-1; Transcription Factors; Transfection | 1995 |
5-Azacytidine changes gene expression and causes developmental arrest of early chick embryo.
Topics: Animals; Azacitidine; Blastocyst; Cell Movement; Chick Embryo; DNA; Gene Expression; Methylation; Morula; Protein Biosynthesis | 1994 |
Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; DNA; Humans; Leukemia; Methylation; Tumor Cells, Cultured | 1995 |
Micronuclei induced by modulators of methylation: analogs of 5-azacytidine.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Deoxycytidine; Leukemia L5178; Methylation; Mice; Mice, Inbred C3H; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutation | 1995 |
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
Topics: Azacitidine; Base Sequence; Cadherins; Carcinoma; DNA Primers; DNA, Neoplasm; Gene Expression; Genes, Regulator; Genes, Tumor Suppressor; Humans; Methylation; Molecular Sequence Data; Neoplasm Invasiveness; Oligodeoxyribonucleotides; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1995 |
Increased DT-diaphorase activity in transformed and tumorigenic pancreatic acinar cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Genes, ras; In Vitro Techniques; Methylation; NAD(P)H Dehydrogenase (Quinone); NADH Dehydrogenase; Pancreatic Neoplasms; Rats; Rats, Inbred F344 | 1995 |
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.
Topics: Antigens, Viral; Azacitidine; Base Sequence; DNA (Cytosine-5-)-Methyltransferases; DNA Footprinting; DNA-Binding Proteins; DNA, Viral; Enzyme Inhibitors; Epstein-Barr Virus Nuclear Antigens; Gene Expression Regulation, Viral; Herpesvirus 4, Human; Methylation; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; Sequence Alignment; Sequence Homology, Nucleic Acid; Transcription, Genetic; Virus Latency | 1995 |
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine.
Topics: Azacitidine; Base Sequence; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA; DNA Modification Methylases; Enzyme Inhibitors; Gene Expression Regulation; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Protein Kinase Inhibitors; Tumor Cells, Cultured | 1995 |
Impaired chromosome segregation in plant anaphase after moderate hypomethylation of DNA.
Topics: Allium; Anaphase; Azacitidine; Cell Division; Chromatids; Chromosomes; DNA, Plant; Kinetics; Methylation; Mitosis; Telophase | 1995 |
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.
Topics: 5-Methylcytosine; Alleles; Azacitidine; Base Sequence; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Carrier Proteins; Chromosomes, Human, Pair 9; CpG Islands; Cyclin-Dependent Kinase Inhibitor p16; Cytosine; Decitabine; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glioma; Head and Neck Neoplasms; Humans; Lung Neoplasms; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
2'-deoxy-5-azacytidine increases binding of cisplatin to DNA by a mechanism independent of DNA hypomethylation.
Topics: Azacitidine; Cisplatin; Decitabine; DNA; DNA Damage; Drug Synergism; Humans; Methylation; Plasmids; Spectrophotometry, Atomic | 1993 |
Induction of replicative senescence by 5-azacytidine: fundamental cell kinetic differences between human diploid fibroblasts and NIH-3T3 cells.
Topics: 3T3 Cells; Acridine Orange; Amniotic Fluid; Animals; Azacitidine; Bromodeoxyuridine; Cell Division; Cell Separation; Cells, Cultured; Cellular Senescence; Flow Cytometry; G1 Phase; G2 Phase; Humans; Methylation; Mice; RNA | 1993 |
Transient expression of a human beta-actin promoter/lacZ gene introduced into mouse embryos correlates with a low degree of methylation.
Topics: Actins; Animals; Azacitidine; Base Sequence; beta-Galactosidase; Blastocyst; Blastomeres; Female; Gene Expression Regulation; Genes, Synthetic; Humans; Male; Methylation; Mice; Mice, Transgenic; Microinjections; Molecular Sequence Data; Polymerase Chain Reaction; Promoter Regions, Genetic; Recombinant Fusion Proteins | 1993 |
Treatment of Agrobacterium or leaf disks with 5-azacytidine increases transgene expression in tobacco.
Topics: Agrobacterium tumefaciens; Azacitidine; Gene Expression Regulation; Glucuronidase; Methylation; Nicotiana; Plants, Genetically Modified; Plants, Toxic; Transformation, Genetic | 1993 |
Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin.
Topics: Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; DNA; DNA Damage; DNA, Satellite; Heterochromatin; Humans; In Situ Hybridization, Fluorescence; Lymphocytes; Methylation; Nucleic Acid Denaturation | 1993 |
The role of polyamine metabolism in dimorphism of Yarrowia lipolytica.
Topics: Azacitidine; DNA, Fungal; Eflornithine; Methylation; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Saccharomycetales | 1993 |
HLA-E is the only class I gene that escapes CpG methylation and is transcriptionally active in the trophoblast-derived human cell line JAR.
Topics: Azacitidine; Base Sequence; Choriocarcinoma; Electrophoresis, Gel, Pulsed-Field; Gene Expression Regulation; Genes; Genes, MHC Class I; Histocompatibility Antigens Class I; HLA Antigens; HLA-E Antigens; In Vitro Techniques; Methylation; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Restriction Mapping; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Post-UV survival and mutagenesis in DNA repair-proficient and -deficient strains of Escherichia coli K-12 grown in 5-azacytidine to inhibit DNA cytosine methylation: evidence for mutagenic excision repair.
Topics: Azacitidine; Cytosine; DNA Repair; DNA, Bacterial; Escherichia coli; Methylation; Mutagenesis; Ultraviolet Rays | 1993 |
5-Aza-2'-deoxycytidine: cell differentiation and DNA methylation.
Topics: Antineoplastic Agents; Azacitidine; Cartilage; Cell Differentiation; Cell Line; Decitabine; DNA; Gene Expression Regulation; Methylation; Muscle Proteins; MyoD Protein; Phenotype | 1993 |
Effects of 5-aza-2'-deoxycytidine on differentiation and oncogene expression in the human monoblastic leukemia cell line U-937.
Topics: Antigens, Surface; Antineoplastic Agents; Azacitidine; Cell Adhesion; Cell Differentiation; Cell Division; Decitabine; DNA; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, myc; Humans; Leukemia, Monocytic, Acute; Macrophages; Methylation; Monocytes; Tumor Cells, Cultured | 1993 |
5-Azadeoxycytidine distinguishes between active and inactive X chromosome condensation.
Topics: Animals; Azacitidine; Cell Cycle; Cell Line; Chromosome Banding; Gene Expression Regulation; Heterochromatin; Humans; Methylation; Mitosis; X Chromosome | 1993 |
Regulation of gene expression involved in the progression of human breast cancer to hormone independence.
Topics: Azacitidine; Binding Sites; Breast Neoplasms; Cell Division; DNA; Epidermal Growth Factor; ErbB Receptors; Estrogens; Gene Expression Regulation, Neoplastic; Humans; Methylation; Receptors, Estrogen; Tumor Cells, Cultured | 1993 |
Cell-cycle dependent micronucleus formation and mitotic disturbances induced by 5-azacytidine in mammalian cells.
Topics: Anaphase; Animals; Azacitidine; Chromatids; DNA; DNA Damage; Heterochromatin; Methylation; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Microscopy, Ultraviolet; Mitosis; Mutagens; S Phase; Spindle Apparatus; Tumor Cells, Cultured | 1993 |
Hemidemethylation is sufficient for chromatin relaxation and transcriptional activation of methylated aprt gene in mouse P19 embryonal carcinoma cell line.
Topics: Adenine Phosphoribosyltransferase; Animals; Antineoplastic Agents; Azacitidine; Chromatin; Decitabine; Enzyme Activation; Gene Expression Regulation, Enzymologic; Methylation; Mice; Teratoma; Transcription, Genetic; Tumor Cells, Cultured | 1993 |
Novel regulation of an MHC class I gene response to interferon-gamma.
Topics: 3T3 Cells; Animals; Azacitidine; Base Sequence; Gene Expression Regulation; Genes, MHC Class I; H-2 Antigens; In Vitro Techniques; Interferon-gamma; Methylation; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Recombinant Proteins; Transfection | 1993 |
Isolation of Escherichia coli mutants lacking methylcytosine-dependent restriction systems for cloning extensively methylated frog virus 3 DNA.
Topics: 5-Methylcytosine; Ampicillin Resistance; Azacitidine; Base Sequence; Clone Cells; Cloning, Molecular; Cytosine; DNA Transposable Elements; DNA-Binding Proteins; DNA-Cytosine Methylases; DNA, Viral; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Iridoviridae; Methylation; Molecular Sequence Data; Mutation; Plasmids; Substrate Specificity; Transformation, Genetic | 1993 |
DNA methylation is not involved in growth regulation of gene expression of proliferating cell nuclear antigen.
Topics: Animals; Azacitidine; Cell Division; Cells, Cultured; Culture Media; Gene Expression Regulation; Genes; In Vitro Techniques; Male; Methylation; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Restriction Mapping; RNA, Messenger | 1993 |
Region-specific methylation of the parathyroid hormone-related peptide gene determines its expression in human renal carcinoma cell lines.
Topics: Azacitidine; Blotting, Southern; Chloramphenicol O-Acetyltransferase; DNA Probes; DNA, Neoplasm; Gene Expression; Humans; Kidney Neoplasms; Methylation; Neoplasm Proteins; Parathyroid Hormone-Related Protein; Protein Biosynthesis; Proteins; Recombinant Fusion Proteins; Restriction Mapping; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1993 |
The effect of 5-azacytidine (5-aza-CR) and its analogue on cell differentiation and DNA methylation of HL-60 cells.
Topics: Antineoplastic Agents; Azacitidine; Cell Differentiation; Decitabine; DNA-Cytosine Methylases; DNA-Directed RNA Polymerases; DNA, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Methylation; Tumor Cells, Cultured | 1993 |
Latency and reactivation of Marek's disease virus in B lymphocytes transformed by avian leukosis virus.
Topics: Alpharetrovirus; Animals; Azacitidine; B-Lymphocytes; Cell Line; Cell Transformation, Viral; Chick Embryo; DNA, Viral; Herpesvirus 2, Gallid; Methylation; Virus Latency | 1993 |
HRF20/CD59 complement regulatory protein expression is phenotype-dependent and inducible by the hypomethylating agent 5-azacytidine on Burkitt's lymphoma cell lines.
Topics: Antigens, CD; Azacitidine; B-Lymphocytes; Burkitt Lymphoma; CD59 Antigens; Cell Line, Transformed; DNA, Neoplasm; Gene Expression; Herpesvirus 4, Human; Humans; Immunophenotyping; Lymphocyte Activation; Membrane Glycoproteins; Methylation; Tumor Cells, Cultured; Up-Regulation | 1993 |
Methylation of the regulatory region of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene leads to its transcriptional inactivation.
Topics: Animals; Animals, Newborn; Azacitidine; DNA; Exons; Fetus; Gene Expression; Hydroxymethylglutaryl-CoA Synthase; Kidney; Liver Neoplasms, Experimental; Male; Methylation; Mitochondria, Liver; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Restriction Mapping; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Persistence of increased levels of ribosomal gene activity in CHO-K1 cells treated in vitro with demethylating agents.
Topics: Animals; Antimetabolites; Azacitidine; CHO Cells; Chromosome Deletion; Clone Cells; Cricetinae; DNA, Ribosomal; Ethionine; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Methylation; Mitotic Index; Mutagens; Nucleolus Organizer Region; Silver Staining | 1995 |
5-Aza deoxyCytidine-induced inhibition of differentiation of spermatogonia into spermatocytes in the mouse.
Topics: Animals; Antispermatogenic Agents; Azacitidine; Cell Differentiation; Decitabine; DNA; DNA Modification Methylases; Isotope Labeling; Male; Methylation; Mice; Spermatocytes; Spermatogenesis; Spermatogonia | 1995 |
Epigenetic control of sexual phenotype in a dioecious plant, Melandrium album.
Topics: Azacitidine; DNA, Plant; Gene Expression Regulation, Plant; Methylation; Phenotype; Plant Development; Plants; Reproduction | 1996 |
Restriction enzyme buffers and 5-azacytidine induce loss of protein and banding in plant metaphase chromosomes.
Topics: Azacitidine; Buffers; Chromosome Banding; Chromosomes; Deoxyribonucleases, Type II Site-Specific; DNA Restriction Enzymes; DNA, Plant; Fabaceae; Karyotyping; Metaphase; Methylation; Plant Proteins; Plant Roots; Plants, Medicinal | 1995 |
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation.
Topics: Astrocytoma; Azacitidine; Base Sequence; Brain Chemistry; Brain Neoplasms; Carrier Proteins; Chromatin; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Glioblastoma; Glioma; Humans; Methylation; Molecular Sequence Data; Neoplasm Proteins; Regulatory Sequences, Nucleic Acid; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured | 1996 |
Hypermethylated myoblasts specifically deficient in MyoD autoactivation as a consequence of instability of MyoD.
Topics: 3T3 Cells; Animals; Azacitidine; Cell Differentiation; Cell Line; Cell Nucleus; Fibroblasts; Gene Expression; Genetic Complementation Test; Humans; Kinetics; Methylation; Mice; Muscle, Skeletal; MyoD Protein; Protease Inhibitors; Receptors, Estrogen; Recombinant Fusion Proteins | 1996 |
Promoter-specific modulation of insulin-like growth factor II genomic imprinting by inhibitors of DNA methylation.
Topics: Animals; Animals, Newborn; Astrocytes; Azacitidine; Cells, Cultured; Decitabine; DNA Modification Methylases; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Genomic Imprinting; Humans; Insulin-Like Growth Factor II; Methylation; Mice; Promoter Regions, Genetic | 1996 |
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Azacitidine; Base Sequence; Decitabine; Dinucleoside Phosphates; DNA; DNA Modification Methylases; DNA Primers; DNA Probes; DNA, Neoplasm; Enzyme Inhibitors; Genome, Human; Humans; Male; Melanoma; Melanoma-Specific Antigens; Methylation; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; T-Lymphocytes, Cytotoxic; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Regulation of human endogenous retrovirus-K Gag expression in teratocarcinoma cell lines and human tumours.
Topics: Azacitidine; Butyrates; Butyric Acid; DNA Methylation; DNA, Viral; Female; Gene Products, gag; Humans; Male; Methylation; Ovarian Neoplasms; Retroelements; Teratocarcinoma; Testicular Neoplasms; Tumor Cells, Cultured | 1996 |
5-Azacytidine and BDNF enhance the maturation of neurons derived from EGF-generated neural stem cells.
Topics: Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured; Epidermal Growth Factor; Methylation; Mice; Microtubule Proteins; Microtubule-Associated Proteins; Nerve Tissue Proteins; Neurons; Stem Cells; Subcellular Fractions; tau Proteins | 1997 |
Differential chromosome sensitivity to 5-azacytidine in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Antimetabolites, Antineoplastic; Azacitidine; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 9; DNA; Heterochromatin; Humans; Male; Methylation | 1998 |
Methylation of a CpG island within the promoter region of the KAI1 metastasis suppressor gene is not responsible for down-regulation of KAI1 expression in invasive cancers or cancer cell lines.
Topics: Antigens, CD; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Carcinoma, Transitional Cell; CpG Islands; Down-Regulation; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Kangai-1 Protein; Membrane Glycoproteins; Methylation; Molecular Sequence Data; Neoplasm Invasiveness; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Caspase 10; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Decitabine; Dose-Response Relationship, Drug; Enzyme Inhibitors; GPI-Linked Proteins; Humans; Jurkat Cells; Membrane Glycoproteins; Methylation; Neuroblastoma; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 10c; Reverse Transcriptase Polymerase Chain Reaction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor Decoy Receptors; Tumor Necrosis Factor-alpha | 2001 |
Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation.
Topics: Alkylating Agents; Alleles; Animals; Animals, Newborn; Azacitidine; Blotting, Northern; Blotting, Southern; Cell Line; Cells, Cultured; CpG Islands; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Silencing; Genotype; Keratinocytes; Methylation; Mice; Mice, Inbred BALB C; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Sensitivity and Specificity; Signal Transduction; Sulfites; Time Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2001 |
Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells.
Topics: Animals; Asparaginase; Aspartate-Ammonia Ligase; Azacitidine; Base Sequence; Blotting, Northern; CpG Islands; Decitabine; DNA; DNA Modification Methylases; DNA Primers; Gene Amplification; Liver; Lymphoma; Methylation; Mice; Mice, Inbred C3H; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Nucleic Acid; Spleen; Tumor Cells, Cultured | 2001 |
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Bone Neoplasms; Caspase 3; Caspase 8; Caspase 9; Caspases; Decitabine; DNA Modification Methylases; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Induction; Gene Transfer Techniques; Humans; Membrane Glycoproteins; Methylation; Neoplasm Proteins; Receptors, Tumor Necrosis Factor; RNA, Messenger; Sarcoma, Ewing; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Reduced expression of syndecan-1 affects metastatic potential and clinical outcome in patients with colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Azacitidine; Chi-Square Distribution; Colorectal Neoplasms; Decitabine; Female; Humans; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Lymphatic Metastasis; Male; Membrane Glycoproteins; Methylation; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Prognosis; Proteoglycans; RNA, Messenger; RNA, Neoplasm; Survival Analysis; Syndecan-1; Syndecans; Tumor Cells, Cultured | 2001 |
Reduced expression of intercellular adhesion molecule-1 in ovarian adenocarcinomas.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; DNA Primers; DNA, Neoplasm; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Intercellular Adhesion Molecule-1; Loss of Heterozygosity; Methylation; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Prognosis; RNA, Messenger; Survival Analysis; Tumor Cells, Cultured | 2001 |
Aberrant methylation and histone deacetylation of cyclooxygenase 2 in gastric cancer.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cyclooxygenase 2; Cytosine; Decitabine; DNA; DNA Methylation; Enzyme Inhibitors; Gastric Mucosa; Gene Silencing; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Isoenzymes; Membrane Proteins; Methylation; Polymorphism, Single-Stranded Conformational; Precipitin Tests; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; Stomach Neoplasms; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells.
Topics: Animals; Azacitidine; Brain; Butadienes; Caveolin 1; Caveolins; Cell Line; Decitabine; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Gene Expression Regulation; Gene Silencing; Genes, Reporter; Humans; Hydroxamic Acids; Methylation; Mice; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Neurons; Nitriles; Promoter Regions, Genetic; Receptors, Estrogen; RNA, Messenger; Transcription, Genetic | 2002 |
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Culture Techniques; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Gene Silencing; Histones; Humans; Lysine; Methylation; Precipitin Tests; Tumor Cells, Cultured; Tumor Suppressor Protein p14ARF; Urinary Bladder Neoplasms | 2002 |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Tumor Cells, Cultured | 2003 |
Dependence of histone modifications and gene expression on DNA hypermethylation in cancer.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinases; Methylation; Neoplasm Invasiveness; Pancreatic Neoplasms; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Control mechanisms in the regulation of telomerase reverse transcriptase expression in differentiating human teratocarcinoma cells.
Topics: Antineoplastic Agents; Azacitidine; Catalytic Domain; Cell Differentiation; DNA (Cytosine-5-)-Methyltransferases; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Hydroxamic Acids; Methylation; Promoter Regions, Genetic; Telomerase; Teratocarcinoma; Tretinoin; Tumor Cells, Cultured | 2003 |
Sera from liver failure patients and a demethylating agent stimulate transdifferentiation of murine bone marrow cells into hepatocytes in coculture with nonparenchymal liver cells.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Blood Proteins; Bone Marrow Cells; Cell Culture Techniques; Cell Differentiation; Child; Coculture Techniques; Hepatocytes; Humans; Liver; Liver Failure; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged | 2003 |
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma.
Topics: Antigens, Nuclear; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; Biomarkers, Tumor; CpG Islands; DEAD-box RNA Helicases; Decitabine; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Methylation; Molecular Sequence Data; Neoplasm Staging; Nuclear Proteins; Oligonucleotide Probes; Precancerous Conditions; Promoter Regions, Genetic; Stomach Neoplasms; Transcription Factors; Tumor Cells, Cultured | 2003 |
Epigenetic inactivation of laminin-5-encoding genes in lung cancers.
Topics: Azacitidine; Carcinoid Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Adhesion Molecules; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Methylation; Humans; Kalinin; Laminin; Lung Neoplasms; Lymphocytes; Methylation; Models, Genetic; Mouth Mucosa; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Sulfites; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation.
Topics: Antioxidants; Azacitidine; Base Sequence; Blotting, Northern; Blotting, Western; Caco-2 Cells; Cell Differentiation; Cell Nucleus; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; HeLa Cells; Humans; Luciferases; Methylation; Molecular Sequence Data; Monoamine Oxidase; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Signal Transduction; Software; Sp1 Transcription Factor; Sp3 Transcription Factor; Sulfites; Time Factors; Transcription Factors; Transcriptional Activation; Transfection; Up-Regulation | 2003 |
Effects of histone deacetylation and DNA methylation on the constitutive and TCDD-inducible expressions of the human CYP1 family in MCF-7 and HeLa cells.
Topics: 5' Flanking Region; Aryl Hydrocarbon Hydroxylases; Azacitidine; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Dealkylation; DNA; Environmental Pollutants; Gene Expression Regulation, Enzymologic; HeLa Cells; Histones; Humans; Hydroxamic Acids; Methylation; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfites; Tumor Cells, Cultured | 2003 |
Altered expression of the septin gene, SEPT9, in ovarian neoplasia.
Topics: Adult; Azacitidine; Base Sequence; Cell Line, Tumor; DNA, Circular; Female; Fetus; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Humans; Methylation; Mutation; Ovarian Neoplasms; Protein Splicing; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Septins; Transcription, Genetic | 2003 |
Epigenetic silencing of the HIC-1 gene in human medulloblastomas.
Topics: Adolescent; Adult; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Northern; Cerebellar Neoplasms; Child; Child, Preschool; Cystine; Decitabine; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Glycine; Humans; Infant; Loss of Heterozygosity; Male; Medulloblastoma; Methylation; Middle Aged; Molecular Sequence Data; Myogenic Regulatory Factors; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; RNA, Messenger; Sulfites; Tumor Cells, Cultured | 2003 |
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.
Topics: Acetylation; Alpharetrovirus; Animals; Azacitidine; Cell Line; Cell Transformation, Viral; Chickens; Chromatin; CpG Islands; DNA Methylation; Erythroid Cells; Flow Cytometry; Gene Dosage; Gene Silencing; Genes, Reporter; Histones; Kinetics; Lysine; Methylation; Models, Genetic; Polymerase Chain Reaction; Precipitin Tests; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Transcription, Genetic; Transgenes | 2004 |
Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.
Topics: Adult; Antigens, CD34; Antimetabolites, Antineoplastic; Azacitidine; Cell Division; Cells, Cultured; Decitabine; Hematopoietic Stem Cells; Humans; Hydroxamic Acids; In Vitro Techniques; Methylation; Phenotype; Protein Synthesis Inhibitors; Thy-1 Antigens | 2004 |
Regulation of Chk2 gene expression in lymphoid malignancies: involvement of epigenetic mechanisms in Hodgkin's lymphoma cell lines.
Topics: Acetylation; Apoptosis; Azacitidine; Butyrates; Cell Line, Tumor; Checkpoint Kinase 2; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Hodgkin Disease; Humans; Hydroxamic Acids; Lymphoma; Methylation; Protein Serine-Threonine Kinases; RNA, Messenger | 2004 |
Demethylating agent, 5-azacytidine, reverses differentiation of embryonic stem cells.
Topics: Alkaline Phosphatase; Animals; Azacitidine; Cell Differentiation; Cell Line; DNA Methylation; Embryo, Mammalian; Enzyme Inhibitors; Flow Cytometry; Methylation; Mice; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; RNA, Untranslated; Stem Cells; Sulfites | 2004 |
Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages.
Topics: Adenoviridae; Animals; Azacitidine; Cell Line; Cholestanetriol 26-Monooxygenase; Cholesterol; Cytomegalovirus; DEAE-Dextran; DNA; DNA Methylation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genes, Reporter; Green Fluorescent Proteins; Humans; Lipids; Macrophages; Methylation; Mice; Microscopy, Confocal; Plasmids; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Steroid Hydroxylases; Transfection | 2005 |
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Topics: Annexin A5; Apoptosis; Azacitidine; Benzothiazoles; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA, Complementary; DNA, Neoplasm; Down-Regulation; Enzyme Inhibitors; Flow Cytometry; G2 Phase; GADD45 Proteins; Humans; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Methylation; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2005 |
Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas.
Topics: Astrocytoma; Azacitidine; Base Sequence; Brain; Cadherins; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Exons; Gene Silencing; Humans; Methylation; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Protocadherins; Reverse Transcriptase Polymerase Chain Reaction; Sulfites; Transcription, Genetic | 2005 |
5-Azacytidine suppresses RNA polymerase II recruitment to the SLPI gene.
Topics: Animals; Azacitidine; Cell Line; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Interleukin-1; Methylation; Protein Methyltransferases; Proteinase Inhibitory Proteins, Secretory; Proteins; RNA Polymerase II; Transcription, Genetic | 2005 |
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.
Topics: Acetylation; Animals; Azacitidine; beta-Galactosidase; Blotting, Western; Cell Line; Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Endothelium, Vascular; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Mice; Mice, Transgenic; Models, Genetic; Muscle, Smooth; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; Serine; Time Factors; Transgenes; Umbilical Veins | 2005 |
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
Topics: Azacitidine; Calreticulin; Cell Line, Tumor; Choriocarcinoma; Decitabine; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens Class I; HLA Antigens; HLA-G Antigens; Humans; Melanoma; Methylation; Promoter Regions, Genetic; Transcription, Genetic | 2005 |
Rumex acetosa Y chromosomes: constitutive or facultative heterochromatin?
Topics: Azacitidine; Cell Culture Techniques; Cell Nucleus; Chromatin Assembly and Disassembly; Chromosomes, Plant; Gene Expression Regulation, Plant; Heterochromatin; Histones; Meristem; Methylation; Plant Roots; Rumex; Y Chromosome | 2005 |
The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells.
Topics: Amsacrine; Animals; Antineoplastic Agents; Azacitidine; CHO Cells; Chromosome Segregation; Chromosomes; Cricetinae; Cricetulus; DNA; DNA Damage; DNA Replication; DNA Restriction Enzymes; Dose-Response Relationship, Drug; Electrophoresis, Gel, Pulsed-Field; Methylation; Topoisomerase II Inhibitors | 2005 |
Dynamic DNA methylation and histone modifications contribute to lentiviral transgene silencing in murine embryonic carcinoma cells.
Topics: Animals; Azacitidine; beta-Galactosidase; Chromatin; CpG Islands; DNA Methylation; Gene Silencing; Histones; Lentivirus; Methylation; Mice; Neoplastic Stem Cells; Peptide Elongation Factor 1; Promoter Regions, Genetic; Transduction, Genetic; Virus Activation | 2005 |
Tissue-specific and de novo promoter methylation of the mouse glucose transporter 2.
Topics: 5' Flanking Region; Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; Gene Expression Regulation; Genes, p53; Glucose Transporter Type 2; Hepatocytes; Liver; Male; Methylation; Mice; Mice, Inbred C57BL; Organ Specificity; Promoter Regions, Genetic; Sulfites | 2005 |
A pharmacodynamic study of 5-azacytidine in the P39 cell line.
Topics: Apoptosis; Azacitidine; Cadherins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Humans; Leukemia, Myeloid; Methylation; Myogenic Regulatory Factors; Time Factors | 2006 |
Aberrant methylation of the eyes absent 4 gene in ulcerative colitis-associated dysplasia.
Topics: Azacitidine; Biomarkers; Cell Line; Chronic Disease; Colitis, Ulcerative; Colonic Neoplasms; Colonic Polyps; Decitabine; Humans; Hydroxamic Acids; Methylation; Polymerase Chain Reaction; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trans-Activators | 2006 |
Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Biomarkers, Tumor; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Humans; Leukemia, Promyelocytic, Acute; Methylation; Multivariate Analysis; Prognosis; Recurrence; Remission Induction; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; RNA, Messenger; Sensitivity and Specificity; Survival Rate; Tretinoin; Tumor Cells, Cultured | 2006 |
Mouse follicular and marginal zone B cells show differential expression of Dnmt3a and sensitivity to 5'-azacytidine.
Topics: Animals; Azacitidine; B-Lymphocytes; Cell Death; Cells, Cultured; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Gene Expression Regulation; Injections, Intraperitoneal; Methylation; Mice; Spleen | 2006 |
Analysis of genes upregulated by the demethylating agent 5-aza-2'-deoxycytidine in gastric cancer cell lines.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA, Complementary; Gene Expression Regulation, Neoplastic; Genome, Human; Humans; Methylation; Oligonucleotide Array Sequence Analysis; RNA, Messenger; Stomach Neoplasms; Sulfates; Time Factors; Up-Regulation | 2006 |
Excess methionine suppresses the methylation cycle and inhibits neural tube closure in mouse embryos.
Topics: Animals; Azacitidine; Embryo Culture Techniques; Embryo, Mammalian; Folic Acid; Methionine; Methylation; Mice; Neural Tube Defects; Phenotype | 2006 |
DNA mismatch repair as an effector for promoting phorbol ester-induced apoptotic DNA damage and cell killing: implications in tumor promotion.
Topics: Apoptosis; Azacitidine; Base Pair Mismatch; Cell Line, Tumor; CpG Islands; Decitabine; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Humans; Methylation; Neoplasms; Phorbol Esters; Protein Kinase C; Protein Kinase Inhibitors; Reactive Oxygen Species | 2006 |
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; Enzyme Inhibitors; Genes, Tumor Suppressor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Protein Methyltransferases; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.
Topics: Adult; Antimetabolites, Antineoplastic; Apoptosis; Astrocytoma; Azacitidine; Brain Neoplasms; Cell Line, Tumor; Dealkylation; DNA; Down-Regulation; Female; Flow Cytometry; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfates; Tumor Suppressor Proteins | 2006 |
Low-dose decitabine and high-risk MDS.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methylation; Myelodysplastic Syndromes; Neoplasm Proteins; Protein Processing, Post-Translational; Randomized Controlled Trials as Topic; Remission Induction; Risk Factors | 2006 |
Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
Topics: Annexin A5; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Decitabine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Hydroxamic Acids; Methylation; Pancreatic Neoplasms; Vorinostat | 2007 |
Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters.
Topics: Animals; Azacitidine; Cell Differentiation; Cell Line; Chromatin Immunoprecipitation; Epigenesis, Genetic; Histones; Hydroxamic Acids; Methyl-CpG-Binding Protein 2; Methylation; Mice; Models, Biological; Neurons; Promoter Regions, Genetic; Receptors, Opioid, mu; RNA, Small Interfering; Transcription, Genetic | 2007 |
Transcriptional silencing of the TMS1/ASC tumour suppressor gene by an epigenetic mechanism in hepatocellular carcinoma cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Carcinoma, Hepatocellular; CARD Signaling Adaptor Proteins; Cell Line, Tumor; Cytoskeletal Proteins; Decitabine; DNA Methylation; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Liver Neoplasms; Methylation; Promoter Regions, Genetic; RNA, Messenger; RNA, Neoplasm; Transcription, Genetic | 2007 |
Global genomic methylation levels in the liver and gonads of the three-spine stickleback (Gasterosteus aculeatus) after exposure to hexabromocyclododecane and 17-beta oestradiol.
Topics: Animals; Azacitidine; Carcinogens; Decitabine; Deoxycytidine; DNA; Estradiol; Female; Gonads; Hydrocarbons, Brominated; Liver; Male; Methylation; Smegmamorpha | 2008 |
Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing.
Topics: Acetylation; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation; Gene Silencing; Histones; Hydroxamic Acids; Leukemia L1210; Lysine; Methylation; Mice; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Protein Processing, Post-Translational | 2007 |
ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations.
Topics: Animals; Azacitidine; Base Sequence; Cell Proliferation; Decitabine; DNA Methylation; DNA Modification Methylases; Fibromatosis, Aggressive; Gene Expression Regulation; Histones; Humans; Mesoderm; Methylation; Mice; Molecular Sequence Data; NIH 3T3 Cells; Promoter Regions, Genetic; Transcription Factors | 2007 |
DNA methylation state is preserved in the sperm-derived pronucleus of the pig zygote.
Topics: Animals; Azacitidine; Cell Nucleus; CpG Islands; Decitabine; DNA; DNA Methylation; Epigenesis, Genetic; Immunohistochemistry; Male; Methylation; Mice; Polymerase Chain Reaction; Spermatozoa; Swine; Zygote | 2007 |
Hypomethylation of interleukin-4 and -6 promoters in T cells from systemic lupus erythematosus patients.
Topics: Adult; Antimetabolites, Antineoplastic; Azacitidine; Cells, Cultured; DNA; Female; Humans; Interleukin-4; Interleukin-6; Lupus Erythematosus, Systemic; Male; Methylation; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes | 2008 |
Progressive silencing of p14ARF in oesophageal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Barrett Esophagus; Base Sequence; Cell Line; Decitabine; Disease Progression; Epithelial Cells; Esophageal Neoplasms; Female; Gene Silencing; Histones; Humans; Male; Methylation; Middle Aged; Molecular Sequence Data; Survival Rate; Tumor Suppressor Protein p14ARF | 2009 |
Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells.
Topics: Acetylation; Anticarcinogenic Agents; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Chromones; CpG Islands; Decitabine; Deubiquitinating Enzyme CYLD; Down-Regulation; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, p53; Genes, Tumor Suppressor; Genistein; Histones; Humans; Hydroxamic Acids; Male; Methylation; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytoestrogens; Prostatic Neoplasms; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Reverse Transcriptase Polymerase Chain Reaction; Sirtuin 1; Sirtuins; Tumor Suppressor Proteins; Up-Regulation | 2008 |
Hypermethylation-modulated downregulation of claudin-7 expression promotes the progression of colorectal carcinoma.
Topics: Azacitidine; Cell Line, Tumor; Claudins; Colorectal Neoplasms; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Gene Expression; Humans; Lymph Nodes; Lymphatic Metastasis; Membrane Proteins; Methylation; Neoplasm Staging; Promoter Regions, Genetic | 2008 |
Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; B-Lymphocytes; Base Sequence; Burkitt Lymphoma; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Mammalian target of rapamycin pathway inhibition enhances the effects of 5-aza-dC on suppressing cell proliferation in human gastric cancer cell lines.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Base Sequence; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Decitabine; Down-Regulation; Humans; Methylation; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Stomach Neoplasms; TOR Serine-Threonine Kinases; Transcription, Genetic; Up-Regulation | 2008 |
Hypoxic silencing of tumor suppressor RUNX3 by histone modification in gastric cancer cells.
Topics: Acetylation; Azacitidine; Cell Hypoxia; Cell Line, Tumor; Core Binding Factor Alpha 3 Subunit; Decitabine; Disease Progression; DNA Methylation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histocompatibility Antigens; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Methylation; Neoplasm Proteins; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Stomach Neoplasms; Transcription, Genetic | 2009 |
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Topics: Animals; Azacitidine; Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Decitabine; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, Formyl Peptide; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2009 |
[5-aza-2'-deoxycytidine induces changes of histone H3-lysine 9 methylation in bladder tumor cells].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Survival; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Time Factors; Urinary Bladder Neoplasms | 2008 |
Methylation-mediated repression of GADD45alpha in prostate cancer and its role as a potential therapeutic target.
Topics: Antineoplastic Agents; Azacitidine; Cell Cycle Proteins; Cell Line, Tumor; DNA Methylation; DNA Primers; DNA, Neoplasm; Docetaxel; Gene Expression Regulation, Neoplastic; Genome; Humans; Male; Methylation; Nuclear Proteins; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Taxoids; Up-Regulation | 2009 |
Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1.
Topics: Acetylation; Analysis of Variance; Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Inhibitors; Exons; Hippocampus; Histone Deacetylase 1; Histone Deacetylases; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Methyl-CpG-Binding Protein 2; Methylation; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Messenger; Time Factors; Transcription Factors | 2009 |
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Topics: Adenosine; Azacitidine; Blotting, Western; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-7; Methylation; Molecular Structure; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2009 |
Efficient readout of posttranslational codes on the 50-residue tail of histone H3 by high-resolution MS/MS.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA (Cytosine-5-)-Methyltransferases; HeLa Cells; Histones; Humans; Methylation; Protein Processing, Post-Translational; Serine Endopeptidases; Tandem Mass Spectrometry | 2010 |
Induction of Foxp3 demethylation increases regulatory CD4+CD25+ T cells and prevents the occurrence of diabetes in mice.
Topics: Animals; Azacitidine; Base Sequence; CD4-Positive T-Lymphocytes; Decitabine; Diabetes Mellitus, Type 1; Female; Forkhead Transcription Factors; Humans; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Molecular Sequence Data; T-Lymphocytes, Regulatory; Thymus Gland; Treatment Outcome | 2009 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Topics: Adenosine; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors | 2009 |
Multifactorial regulation of E-cadherin expression: an integrative study.
Topics: Azacitidine; Branched DNA Signal Amplification Assay; Cadherins; Cell Adhesion; Cell Line, Tumor; Drug Screening Assays, Antitumor; Epithelial Cells; Gene Dosage; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Methylation; Oligonucleotide Array Sequence Analysis; RNA, Messenger; RNA, Small Interfering; Trans-Activators; Transcription Factors; Up-Regulation; Zinc Finger E-box-Binding Homeobox 1 | 2010 |
Alternative dosing schedules for methylation inhibitors in MDS treatment.
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; Drug Administration Schedule; Humans; Methylation; Myelodysplastic Syndromes | 2009 |
Establishment and characterization of multi-drug resistant, prostate carcinoma-initiating stem-like cells from human prostate cancer cell lines 22RV1.
Topics: Acetylation; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Male; Methylation; Mice; Mice, Nude; Neoplasm Proteins; Neoplastic Stem Cells; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-kit; Time Factors; Tumor Burden | 2010 |
Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines.
Topics: Azacitidine; Decitabine; Gene Silencing; Histones; Humans; Lysine; Male; Methylation; Octamer Transcription Factor-3; Proto-Oncogene Mas; Testicular Neoplasms; Tumor Suppressor Proteins | 2011 |
Chronic prenatal hypoxia induces epigenetic programming of PKC{epsilon} gene repression in rat hearts.
Topics: Animals; Azacitidine; Blotting, Western; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Female; Fetal Heart; Fetal Hypoxia; Gene Expression Regulation, Enzymologic; Male; Methylation; Pregnancy; Promoter Regions, Genetic; Protein Kinase C-epsilon; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sp1 Transcription Factor | 2010 |
Active loss of DNA methylation in two-cell stage goat embryos.
Topics: 5-Methylcytosine; Animals; Azacitidine; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Embryo, Mammalian; Enzyme Inhibitors; Female; Goats; Histones; Immunohistochemistry; Lysine; Male; Methylation; Zygote | 2010 |
Hypomethylation of IL10 and IL13 promoters in CD4+ T cells of patients with systemic lupus erythematosus.
Topics: Adolescent; Adult; Azacitidine; Case-Control Studies; CD4-Positive T-Lymphocytes; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Interleukin-10; Interleukin-13; Lupus Erythematosus, Systemic; Male; Methylation; Polymerase Chain Reaction; Promoter Regions, Genetic | 2010 |
Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent.
Topics: Azacitidine; Cells, Cultured; Decitabine; DNA Modification Methylases; Endometriosis; Endometrium; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Methylation; Promoter Regions, Genetic; Receptors, Progesterone; Stromal Cells | 2010 |
Mechanistic insights on the inhibition of c5 DNA methyltransferases by zebularine.
Topics: Animals; Azacitidine; Base Sequence; Cytidine; Decitabine; DNA; DNA (Cytosine-5-)-Methyltransferases; Enzyme Inhibitors; Humans; Methylation; Mice | 2010 |
Epigenetic silencing of somatostatin in gastric cancer.
Topics: Adenocarcinoma; Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Methylation; Predictive Value of Tests; Reproducibility of Results; RNA, Messenger; Somatostatin; Stomach Neoplasms | 2011 |
Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation.
Topics: Adenine Phosphoribosyltransferase; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2011 |
Demethylation of E-cadherin gene in nasopharyngeal carcinoma could serve as a potential therapeutic strategy.
Topics: Azacitidine; Biomarkers, Tumor; Cadherins; CpG Islands; Decitabine; DNA Modification Methylases; Down-Regulation; Humans; Methylation; Nasopharyngeal Neoplasms; Promoter Regions, Genetic; Transcription, Genetic; Tumor Cells, Cultured | 2011 |
Differentiation induction of cardiac c-kit positive cells from rat heart into sinus node-like cells by 5-azacytidine.
Topics: Animals; Azacitidine; Biomarkers; Cell Differentiation; Cells, Cultured; Enzyme Inhibitors; GATA4 Transcription Factor; Heart; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; Ion Channels; Methylation; Potassium Channels; Proto-Oncogene Proteins c-kit; Rats; Sinoatrial Node | 2011 |
Hypermethylation-modulated down-regulation of CDH1 expression contributes to the progression of esophageal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Azacitidine; Cadherins; Carcinoma, Squamous Cell; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Shape; Cell Survival; Decitabine; DNA Methylation; DNA Modification Methylases; Down-Regulation; Esophageal Neoplasms; Female; Humans; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Promoter Regions, Genetic; Transcription, Genetic | 2011 |
The in vivo induction of sister chromatid exchange by the demethylating agent 5-aza-2'-deoxycytidine.
Topics: Animals; Azacitidine; Cell Death; Decitabine; Male; Methylation; Mice; Mice, Inbred BALB C; Mitotic Index; Sister Chromatid Exchange | 2011 |
Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Decitabine; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; TCF Transcription Factors | 2011 |
Epigenetic inactivation of the miR-124-1 in haematological malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Blotting, Western; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase 6; Epigenesis, Genetic; Female; Hematologic Neoplasms; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Non-Hodgkin; Male; Methylation; MicroRNAs; Middle Aged; Multiple Myeloma; Reverse Transcriptase Polymerase Chain Reaction; Young Adult | 2011 |
Decreased expression of protease-activated receptor 4 in human gastric cancer.
Topics: Aged; Azacitidine; Cell Line, Tumor; Decitabine; DNA Modification Methylases; Down-Regulation; Female; Gastric Mucosa; Gene Expression; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Humans; Male; Methylation; Middle Aged; Promoter Regions, Genetic; Receptors, Thrombin; Sequence Analysis, DNA; Stomach Neoplasms | 2011 |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1, a novel epithelial-mesenchymal transition inducer in pancreatic cancer.
Topics: Azacitidine; Base Sequence; Cell Line, Tumor; Chromatin Immunoprecipitation; Decitabine; Endothelial Cells; Epithelial-Mesenchymal Transition; Heparitin Sulfate; Histones; Humans; Hydroxamic Acids; Methylation; Pancreatic Neoplasms; RNA, Messenger; Sequence Analysis, DNA; Snail Family Transcription Factors; Sulfotransferases; Transcription Factors; Transcriptional Activation | 2011 |
CpG methylation at the USF-binding site mediates cell-specific transcription of human ascorbate transporter SVCT2 exon 1a.
Topics: Azacitidine; CCAAT-Binding Factor; Cell Line; Cell Line, Tumor; CpG Islands; Decitabine; Dinucleoside Phosphates; Exons; Humans; Methylation; Promoter Regions, Genetic; Sodium-Coupled Vitamin C Transporters; Upstream Stimulatory Factors | 2011 |
Azacitidine induces demethylation of p16INK4a and inhibits growth in adult T-cell leukemia/lymphoma.
Topics: Azacitidine; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p16; Humans; Leukemia-Lymphoma, Adult T-Cell; Methylation; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Base Sequence; DNA Primers; Enzyme-Linked Immunosorbent Assay; Histocompatibility Antigens Class I; Human papillomavirus 16; Immunotherapy; Male; Methylation; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Real-Time Polymerase Chain Reaction | 2011 |
5-AZA-2'-deoxycytidine induced demethylation influences N-glycosylation of secreted glycoproteins in ovarian cancer.
Topics: Azacitidine; Carcinoma, Ovarian Epithelial; Decitabine; Female; Glycoproteins; Glycosylation; Glycosyltransferases; Humans; Methylation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polysaccharides | 2011 |
Influence of epigenetic modifications of the interleukin-10 promoter on IL10 gene expression.
Topics: Acetylation; Adenine; Azacitidine; B-Lymphocytes; Cell Line; Chromatin; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Epigenesis, Genetic; Escherichia coli; Gene Expression Regulation; Genotype; Guanine; Histone Deacetylase Inhibitors; Histones; Humans; Interleukin-10; Lipopolysaccharides; Methylation; Polymorphism, Genetic; Promoter Regions, Genetic; RNA, Messenger; Transcription, Genetic | 2012 |
5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS-demethylation and FAS re-expression, and synergism with FAS-ligand.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Base Sequence; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; DNA, Neoplasm; Drug Synergism; Fas Ligand Protein; fas Receptor; Female; Humans; Leukemia, Mast-Cell; Male; Mast Cells; Mastocytosis, Systemic; Methylation; Middle Aged; Molecular Sequence Data; Neoplasm Proteins; Point Mutation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-kit; RNA, Small Interfering | 2012 |
MTA1 expression correlates significantly with ER-alpha methylation in breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Decitabine; DNA Methylation; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Humans; Mammary Glands, Human; Methylation; Middle Aged; Neoplasm Staging; Repressor Proteins; Trans-Activators | 2012 |
[Effects of 5-Aza-2'-deoxycitydine and trichostatin A on expression and methylation of CHFR in human laryngreal carcinoma cell line].
Topics: Azacitidine; Cell Cycle Proteins; Decitabine; DNA Methylation; Gene Expression; Hep G2 Cells; Humans; Hydroxamic Acids; Laryngeal Neoplasms; Methylation; Neoplasm Proteins; Poly-ADP-Ribose Binding Proteins; Promoter Regions, Genetic; Ubiquitin-Protein Ligases | 2012 |
Methylation mediated silencing of miR-23b expression and its role in glioma stem cells.
Topics: Antineoplastic Agents; Azacitidine; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Decitabine; Down-Regulation; Epigenesis, Genetic; Gene Silencing; Glioma; Humans; Methylation; MicroRNAs; Neoplastic Stem Cells; Promoter Regions, Genetic; Temozolomide | 2012 |
Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female rats.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Azacitidine; Behavior, Animal; Cerebral Cortex; Conditioning, Psychological; Corticosterone; Cues; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Down-Regulation; Estradiol; Fear; Female; Histone Deacetylase Inhibitors; Histones; Light; Lysine; Maternal Deprivation; Methylation; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Stress, Psychological; Valproic Acid | 2012 |
Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
Topics: Animals; Anterior Chamber; Antimetabolites, Antineoplastic; Azacitidine; Cecum; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Injections; Injections, Subcutaneous; Lysine; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Up-Regulation | 2013 |
Thrombospondin-1 expression in melanoma is blocked by methylation and targeted reversal by 5-Aza-deoxycytidine suppresses angiogenesis.
Topics: Animals; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Decitabine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Methylation; Mice; Neovascularization, Pathologic; Promoter Regions, Genetic; Xenograft Model Antitumor Assays | 2013 |
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents.
Topics: Animals; Antineoplastic Agents; Azacitidine; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Humans; Indoles; Methylation; Mice; Mitogen-Activated Protein Kinases; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Signal Transduction; Sulfonamides; Vemurafenib | 2013 |
Predicting infections in high-risk patients with myelodysplastic syndrome/acute myeloid leukemia treated with azacitidine: a retrospective multicenter study.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Azacitidine; Chromosome Aberrations; Disease Susceptibility; Female; Humans; Incidence; Infections; Israel; Leukemia, Myeloid, Acute; Male; Methylation; Middle Aged; Myelodysplastic Syndromes; Neutropenia; Retrospective Studies; Risk Factors; Severity of Illness Index; Thrombocytopenia | 2013 |
The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2).
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Apoptosis; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cyclophosphamide; Decitabine; DNA Methylation; DNA, Neoplasm; Docetaxel; Down-Regulation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Heparan Sulfate Proteoglycans; Humans; Methylation; MicroRNAs; Neoplasm Proteins; RNA, Neoplasm; Taxoids | 2013 |
Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.
Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Animals; Apoptosis; Azacitidine; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Carcinogenesis; Carcinoma, Hepatocellular; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Decitabine; Epigenesis, Genetic; Female; G2 Phase Cell Cycle Checkpoints; Heterografts; Humans; Liver Neoplasms; Male; Methylation; Mice, Nude; Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Transcription Factor 4; Transcription Factors; Wnt Signaling Pathway | 2013 |
Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus.
Topics: Azacitidine; CCCTC-Binding Factor; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Chromosomal Proteins, Non-Histone; Cohesins; Decitabine; DNA Methylation; Down-Regulation; Enhancer Elements, Genetic; Enzyme Inhibitors; Gene Expression; Genetic Loci; Genomic Imprinting; Histones; Humans; Insulin-Like Growth Factor II; Methylation; Mucoproteins; Neoplasm Proteins; Nucleosomes; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; RNA, Long Noncoding; Transcription Factors | 2013 |
Homocysteine-induced hypermethylation of DDAH2 promoter contributes to apoptosis of endothelial cells.
Topics: Amidohydrolases; Annexin A5; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Survival; Coloring Agents; Endothelial Cells; Homocysteine; Methylation; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Repressor Proteins; Tetrazolium Salts; Thiazoles | 2013 |
FOXP3 demethylation as a means of identifying quantitative defects in regulatory T cells in acute coronary syndrome.
Topics: Acute Coronary Syndrome; Adult; Aged; Atherosclerosis; Azacitidine; Biomarkers; CD4 Antigens; Cells, Cultured; Cholesterol, LDL; Decitabine; DNA Modification Methylases; Down-Regulation; Female; Flow Cytometry; Forkhead Transcription Factors; Humans; Interferon-gamma; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Male; Methylation; Middle Aged; T-Lymphocytes, Regulatory; Transforming Growth Factor beta1; Troponin I; Up-Regulation | 2013 |
Epigenetic modifications during sex change repress gonadotropin stimulation of cyp19a1a in a teleost ricefield eel (Monopterus albus).
Topics: Acetylation; Amino Acid Sequence; Animals; Aromatase; Azacitidine; Base Sequence; CpG Islands; Cyclic AMP; Decitabine; DNA Methylation; Eels; Enzyme Inhibitors; Epigenesis, Genetic; Female; Fish Proteins; Gene Expression; Gonadotropins; Hermaphroditic Organisms; Histones; Male; Methylation; Molecular Sequence Data; Ovary; Reverse Transcriptase Polymerase Chain Reaction; Sex Determination Processes; Testis | 2013 |
Expression of 17β-hydroxysteroid dehydrogenase type 1 in gastric cancer.
Topics: Aged; Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Estradiol; Estradiol Dehydrogenases; Estrone; Female; Humans; Male; Methylation; Stomach Neoplasms; Up-Regulation | 2013 |
The DNA methyl transferase inhibitor, 5'-aza-2-deoxycitidine, enhances the apoptotic effect of Mevastatin in human leukemia HL-60 cells.
Topics: Apoptosis; Azacitidine; Caspases; Decitabine; DNA Modification Methylases; DNA Replication; Drug Synergism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; HL-60 Cells; Humans; L-Lactate Dehydrogenase; Leukemia; Lovastatin; Methylation; Microscopy, Fluorescence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2014 |
The role of Sp1 and EZH2 in the regulation of LMX1A in cervical cancer cells.
Topics: Azacitidine; Base Sequence; Binding Sites; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; LIM-Homeodomain Proteins; Methylation; Molecular Sequence Data; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Sp1 Transcription Factor; Transcription Factors; Uterine Cervical Neoplasms | 2013 |
CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism.
Topics: Azacitidine; B-Lymphocytes; Cell Proliferation; Cells, Cultured; Chromosomes, Human, Pair 12; Decitabine; Disease Progression; Gene Expression Regulation, Leukemic; Humans; Integrin alpha4; Leukemia, Lymphocytic, Chronic, B-Cell; Methylation; Sequence Analysis, DNA; Signal Transduction; Survival Analysis; Trisomy | 2013 |
Protective effect of demethylation treatment on cigarette smoke extract-induced mouse emphysema model.
Topics: Animals; Apoptosis; Azacitidine; Decitabine; Disease Models, Animal; DNA-Binding Proteins; Electron Transport Complex IV; Emphysema; Lung; Male; Methylation; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Proteins; RNA, Messenger; Smoking; Transcription Factors | 2013 |
Redistribution of H3K27me3 and acetylated histone H4 upon exposure to azacitidine and decitabine results in de-repression of the AML1/ETO target gene IL3.
Topics: Acetylation; Apoptosis; Azacitidine; Cell Line, Tumor; Cell Survival; Chromatin Assembly and Disassembly; Core Binding Factor Alpha 2 Subunit; Decitabine; DNA Modification Methylases; Gene Silencing; Histones; Humans; Interleukin-3; Leukemia, Myeloid, Acute; Methylation; Promoter Regions, Genetic; Proto-Oncogene Proteins; RUNX1 Translocation Partner 1 Protein; Transcription Factors | 2014 |
Impact of 5-aza-2'-deoxycytidine and epigallocatechin-3-gallate for induction of human regulatory T cells.
Topics: Azacitidine; Catechin; Decitabine; Forkhead Transcription Factors; Humans; Male; Methylation; Oligonucleotide Array Sequence Analysis; T-Lymphocytes, Regulatory | 2014 |
Effects of 5-azacytidine on RUNX3 gene expression and the biological behavior of esophageal carcinoma cells.
Topics: Animals; Azacitidine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Core Binding Factor Alpha 3 Subunit; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Xenograft Model Antitumor Assays | 2014 |
microRNA-34b/c on chromosome 11q23 is aberrantly methylated in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Cell Cycle Proteins; Chromosomes, Human, Pair 11; Cohort Studies; Female; Gene Deletion; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Methylation; MicroRNAs; Middle Aged; Promoter Regions, Genetic | 2014 |
A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression.
Topics: Animals; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Coculture Techniques; Cytoplasm; Decitabine; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Granzymes; Humans; Immunotherapy; Interferon-gamma; Lymphocytes; Membrane Proteins; Methylation; Mice; Mice, SCID; Neoplasm Metastasis; Polymerase Chain Reaction; Receptors, Antigen, T-Cell; RNA, Messenger; Thyroid Neoplasms | 2014 |
Sequential combination of decitabine and idarubicin synergistically enhances anti-leukemia effect followed by demethylating Wnt pathway inhibitor promoters and downregulating Wnt pathway nuclear target.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Cell Nucleus; Cell Proliferation; Decitabine; Down-Regulation; Drug Synergism; Humans; Idarubicin; In Situ Nick-End Labeling; Leukemia; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Wnt Proteins | 2014 |
Combinatorial therapy with acetylation and methylation modifiers attenuates lung vascular hyperpermeability in endotoxemia-induced mouse inflammatory lung injury.
Topics: Acetylation; Acute Lung Injury; Animals; Azacitidine; Blotting, Western; Capillary Permeability; Cell Proliferation; Cell Survival; Chromatin Immunoprecipitation; Decitabine; Disease Models, Animal; Drug Therapy, Combination; Endothelial Cells; Endotoxemia; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Hydroxamic Acids; In Situ Nick-End Labeling; Inflammation; Lung; Male; Methylation; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction | 2014 |
HSPC117 is regulated by epigenetic modification and is involved in the migration of JEG-3 cells.
Topics: Azacitidine; Cell Line, Tumor; Cell Movement; Decitabine; Epigenesis, Genetic; Histones; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methylation; Proteins; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2014 |
Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain.
Topics: Animals; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Methylation; Mice; Morphine; Neuralgia; Neuroblastoma; Pain Measurement; Pain Threshold; Promoter Regions, Genetic; Receptors, Opioid, mu; Sensory Receptor Cells; Spinal Cord | 2014 |
The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy.
Topics: Azacitidine; Bone Marrow Cells; Cell Line, Tumor; Cluster Analysis; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; F-Box Proteins; Gene Expression; Gene Expression Profiling; Gene Knockdown Techniques; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; MicroRNAs; Molecular Targeted Therapy; Myelodysplastic Syndromes; Polycomb Repressive Complex 2 | 2014 |
Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet.
Topics: Animals; Anxiety; Azacitidine; Brain; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Decitabine; Diet, Fat-Restricted; Disease Models, Animal; Enzyme Inhibitors; Fatty Acids, Omega-3; Female; Male; Maze Learning; Methylation; Mice; Neuroblastoma; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Transcription Factors | 2015 |
Treatment of buffalo (Bubalus bubalis) donor cells with trichostatin A and 5-aza-2'-deoxycytidine alters their growth characteristics, gene expression and epigenetic status and improves the in vitro developmental competence, quality and epigenetic status
Topics: Acetylation; Animals; Apoptosis; Azacitidine; Blastocyst; Buffaloes; Cells, Cultured; Cloning, Organism; Decitabine; DNA Methylation; DNA Modification Methylases; Ectogenesis; Embryo Culture Techniques; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; India; Methylation; Protein Processing, Post-Translational | 2016 |
[Effects of 5-aza-2-deoxycytidine on methylation status of RECK gene and cancer cell invasion in tongue cancer SCC-4 cells].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Decitabine; DNA Methylation; GPI-Linked Proteins; Humans; Methylation; Neoplasm Invasiveness; RNA, Messenger; Tongue Neoplasms | 2014 |
BCL2 promotor methylation and miR-15a/16-1 upregulation is associated with sanguinarine-induced apoptotic death in rat HSC-T6 cells.
Topics: Animals; Apoptosis; Azacitidine; Benzophenanthridines; Cell Line; Cell Survival; Decitabine; Down-Regulation; Isoquinolines; Membrane Potential, Mitochondrial; Methylation; MicroRNAs; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-2; Rats; Reactive Oxygen Species; Up-Regulation | 2015 |
NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs.
Topics: 5-Methylcytosine; Azacitidine; Cross-Linking Reagents; Cytoplasm; Enzyme Inhibitors; Golgi Apparatus; HEK293 Cells; HeLa Cells; Humans; In Vitro Techniques; Methylation; RNA, Transfer; tRNA Methyltransferases | 2015 |
Cross talk between poly(ADP-ribose) polymerase 1 methylation and oxidative stress involved in the toxic effect of anatase titanium dioxide nanoparticles.
Topics: Antioxidants; Azacitidine; Cell Line, Tumor; Cell Survival; Decitabine; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Methylation; Methyltransferases; Nanoparticles; Oxidative Stress; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Reactive Oxygen Species; Thioctic Acid; Titanium | 2015 |
Nine years without a new FDA-approved therapy for MDS: how can we break through the impasse?
Topics: Algorithms; Azacitidine; Clinical Trials as Topic; Decitabine; Drug Approval; Drug Industry; Humans; Karyotyping; Lenalidomide; Methylation; Mutation; Myelodysplastic Syndromes; Prognosis; Risk Assessment; Thalidomide; United States; United States Food and Drug Administration | 2015 |
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.
Topics: Age Factors; Aging; Animals; Animals, Newborn; Azacitidine; Brain; Cell Death; D-Aspartate Oxidase; D-Aspartic Acid; Decitabine; Embryo, Mammalian; Enzyme Inhibitors; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2016 |
Inactivation of the WNT5A Alternative Promoter B Is Associated with DNA Methylation and Histone Modification in Osteosarcoma Cell Lines U2OS and SaOS-2.
Topics: Azacitidine; Bone Neoplasms; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; DNA, Neoplasm; Exons; Gene Expression Regulation, Neoplastic; Genes, Reporter; Histone Code; Humans; Luciferases, Renilla; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Osteoblasts; Osteosarcoma; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Transfection; Wnt Proteins; Wnt Signaling Pathway; Wnt-5a Protein | 2016 |
Sustained expression of FMR1 mRNA from reactivated fragile X syndrome alleles after treatment with small molecules that prevent trimethylation of H3K27.
Topics: Azacitidine; Cell Line, Tumor; Decitabine; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Fragile X Mental Retardation Protein; Gene Expression Regulation; Histones; Humans; Male; Methylation; Microsatellite Repeats; Small Molecule Libraries; Up-Regulation | 2016 |
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Topics: Acetylation; Animals; Antineoplastic Agents; Azacitidine; Cell Death; Cell Line, Tumor; Cell Proliferation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; Docetaxel; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Hydroxamic Acids; Kidney; Male; Methylation; Neoplasms; Oligopeptides; Prostatic Neoplasms; Rats; Taxoids | 2016 |
An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer.
Topics: Antineoplastic Agents; Azacitidine; Biomarkers, Tumor; Cell Line, Tumor; Cisplatin; Decitabine; Doxorubicin; Drug Resistance, Neoplasm; Epigenomics; Etoposide; Homeodomain Proteins; Humans; Hydroxamic Acids; Methylation; Neoadjuvant Therapy; Promoter Regions, Genetic; Urinary Bladder Neoplasms; Vinblastine; Vorinostat | 2016 |
Histone demethylase UTX counteracts glucocorticoid deregulation of osteogenesis by modulating histone-dependent and -independent pathways.
Topics: Animals; Azacitidine; beta Catenin; Cells, Cultured; Chromatin Immunoprecipitation; Core Binding Factor Alpha 1 Subunit; Decitabine; DNA Methylation; Glucocorticoids; Histone Demethylases; Histones; Immunoblotting; Intercellular Signaling Peptides and Proteins; Male; Methylation; Mice; Osteogenesis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sp7 Transcription Factor | 2017 |
Hyperglycemia impedes definitive endoderm differentiation of human embryonic stem cells by modulating histone methylation patterns.
Topics: Animals; Antigens, Differentiation; Azacitidine; beta Catenin; Cell Differentiation; Cell Line; Cell Lineage; DNA Modification Methylases; Endoderm; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Female; Gene Expression Regulation, Developmental; Glucose; Histones; Humans; Hyperglycemia; Male; Mesoderm; Methylation; Mice; Mice, Inbred ICR; Pancreas; Promoter Regions, Genetic; Signal Transduction; Wnt Proteins | 2017 |
Combinatorial strategy of epigenetic and hormonal therapies: A novel promising approach for treating advanced prostate cancer.
Topics: Anticarcinogenic Agents; Azacitidine; beta Catenin; Caspase 3; Cell Proliferation; Cyclin D1; Decitabine; Disease Progression; Epigenesis, Genetic; Estrogen Receptor beta; Hormones; Humans; Hydroxamic Acids; Male; Methylation; Nitriles; Propionates; Prostate; Prostatic Neoplasms; Vascular Endothelial Growth Factor A | 2018 |
Methylation-induced silencing of SPG20 facilitates gastric cancer cell proliferation by activating the EGFR/MAPK pathway.
Topics: Animals; Azacitidine; Base Sequence; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Silencing; Humans; Male; MAP Kinase Signaling System; Methylation; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Multivariate Analysis; Nomograms; Prognosis; Proteins; Stomach Neoplasms; Survival Analysis; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2018 |
5-Azacytidine promotes shoot regeneration during Agrobacterium-mediated soybean transformation.
Topics: Agrobacterium tumefaciens; Azacitidine; Cotyledon; DNA Methylation; Fabaceae; Gene Transfer Techniques; Genes, Plant; Genotype; Glycine max; Methylation; Peptide Hydrolases; Plant Shoots; Plants, Genetically Modified; Protoplasts; Regeneration; Sequence Analysis, DNA; Transfection; Transformation, Genetic; Transgenes | 2019 |
Bone marrow ribonucleotide reductase mRNA levels and methylation status as prognostic factors in patients with myelodysplastic syndrome treated with 5-Azacytidine.
Topics: Azacitidine; Bone Marrow; Humans; Methylation; Myelodysplastic Syndromes; Prognosis; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; RNA, Messenger | 2022 |
A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine.
Topics: Anemia; Animals; Azacitidine; Cat Diseases; Cats; Female; Leukopenia; Methylation; Myelodysplastic Syndromes | 2022 |
Study of genetic modifications of flower development and methylation status in phytoplasma infected Brassica (Brassica rapa L.).
Topics: Azacitidine; Brassica; Brassica rapa; Flowers; Gene Expression Regulation, Plant; Methylation; Phytoplasma; Plant Proteins; Plants | 2022 |
Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation.
Topics: Azacitidine; Dioxygenases; DNA-Binding Proteins; Humans; Killer Cells, Natural; Methylation; Mutation; Myelodysplastic Syndromes; Receptors, KIR | 2023 |