Compounds > azacitidine

azacitidine and irinotecan

azacitidine has been researched along with irinotecan in 16 studies

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (25.00)	29.6817
2010's	10 (62.50)	24.3611
2020's	2 (12.50)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Giacomini, KM; Huang, Y; Khuri, N; Kido, Y; Kosaka, A; Morrissey, KM; Sali, A; Wittwer, MB; Zhang, X; Zur, AA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bernard, O; Gagnon, JF; Guillemette, C; Têtu, B; Villeneuve, L	1
Enomoto, M; Iida, S; Ishiguro, M; Kato, K; Makino, H; Morita, S; Sugihara, K; Takagi, Y; Uetake, H	1
Cortesi, F; Crea, F; Danesi, R; Del Tacca, M; Gallegos Ruiz, MI; Giovannetti, E; Mey, V; Nannizzi, S; Peters, GJ; Ricciardi, S	1
Bai, T; Kobayashi, A; Matsuoka, T; Sasaki, N; Tanaka, J; Tanaka, T; Tanizaki, Y; Toujima, S; Utsunomiya, H; Utsunomiya, T; Yamamoto, M; Yukawa, K	1
Aoki, D; Banno, K; Kisu, I; Kobayashi, Y; Masuda, K; Nomura, H; Susumu, N; Tominaga, E; Tsuji, K; Ueki, A; Yamagami, W; Yanokura, M	1
Ikehata, M; Iwakawa, S; Ogawa, M; Tanaka, S; Ueda, K; Yamada, Y	1
Baylin, SB; Dobromilskaya, I; Easwaran, H; Huang, P; Poirier, JT; Rudin, CM; Topper, M; Vendetti, FP; Wrangle, J	1
A Guzzetta, A; Abdelfatah, E; Ahuja, N; Azad, N; B Baylin, S; Hu, Y; Kerner, Z; Sharma, A; Singh, J; Vatapalli, R; Wyatt McMahon, K; Yerram, S; Zahnow, C	1
Fukuda, M; Hosokawa, M; Iwakawa, S; Masuda, A; Tanaka, S; Ueda, K	1
Ahuja, N; Cai, Y; Hu, Y; Karunasena, E; Keer, H; Lerner, L; Morreale, M; Saggi, S; Sen, R; Thakar, M; Ying Lin, W	1
Beydemir, Ş; Demir, Y; Türkeş, C	1
Asaro, G; De Luca, A; Delfini, M; Guglielmi, G; Iavicoli, S; Sciubba, F; Spagnoli, M	1

Reviews

1 review(s) available for azacitidine and irinotecan

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

15 other study(ies) available for azacitidine and irinotecan

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Computer Simulation; Fluorescent Dyes; Organic Cation Transport Proteins; Prescription Drugs	2013
Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Mar-15, Volume: 12, Issue:6 Topics: Azacitidine; Camptothecin; Cell Line, Tumor; CpG Islands; Decitabine; DNA Methylation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucuronides; Glucuronosyltransferase; HCT116 Cells; HT29 Cells; Humans; Hydroxamic Acids; Irinotecan	2006
Effect of combined therapy with low-dose 5-aza-2'-deoxycytidine and irinotecan on colon cancer cell line HCT-15. Annals of surgical oncology, 2007, Volume: 14, Issue:5 Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Azacitidine; Camptothecin; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Irinotecan; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Tumor Suppressor Protein p14ARF	2007
Epigenetic mechanisms of irinotecan sensitivity in colorectal cancer cell lines. Molecular cancer therapeutics, 2009, Volume: 8, Issue:7 Topics: 14-3-3 Proteins; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Azacitidine; Camptothecin; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; DNA Damage; DNA Methylation; DNA Topoisomerases, Type I; Drug Therapy, Combination; Epigenesis, Genetic; Humans; Irinotecan; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2009
Demethylation restores SN38 sensitivity in cells with acquired resistance to SN38 derived from human cervical squamous cancer cells. Oncology reports, 2012, Volume: 27, Issue:4 Topics: Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Azacitidine; Calcium-Calmodulin-Dependent Protein Kinases; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Dealkylation; Death-Associated Protein Kinases; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Uterine Cervical Neoplasms	2012
Association of epigenetic inactivation of the WRN gene with anticancer drug sensitivity in cervical cancer cells. Oncology reports, 2012, Volume: 28, Issue:4 Topics: Adenocarcinoma; Antineoplastic Agents; Azacitidine; Camptothecin; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; DNA Methylation; Epigenesis, Genetic; Exodeoxyribonucleases; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; RecQ Helicases; RNA, Small Interfering; Topoisomerase I Inhibitors; Uterine Cervical Neoplasms; Werner Syndrome Helicase	2012
Different effects of epigenetic modifiers on the cytotoxicity induced by 5-fluorouracil, irinotecan or oxaliplatin in colon cancer cells. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:1 Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Camptothecin; Cell Line, Tumor; Colonic Neoplasms; Decitabine; DNA; DNA Modification Methylases; Drug Synergism; Epigenesis, Genetic; Fluorouracil; HCT116 Cells; Histone Deacetylase Inhibitors; HT29 Cells; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin	2014
Evaluation of azacitidine and entinostat as sensitization agents to cytotoxic chemotherapy in preclinical models of non-small cell lung cancer. Oncotarget, 2015, Jan-01, Volume: 6, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Benzamides; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; DNA Methylation; Drug Evaluation, Preclinical; Epigenesis, Genetic; Female; Histones; Humans; Irinotecan; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Pyridines	2015
Hypomethylating agents synergize with irinotecan to improve response to chemotherapy in colorectal cancer cells. PloS one, 2017, Volume: 12, Issue:4 Topics: Animals; Antineoplastic Agents; ATP-Binding Cassette Transporters; Azacitidine; Caco-2 Cells; Camptothecin; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; DNA Methylation; DNA Repair; Gene Expression; Gene Expression Profiling; HCT116 Cells; Humans; Irinotecan; Long Interspersed Nucleotide Elements; Mice; Mice, Inbred NOD; Mice, SCID	2017
Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells. Drug metabolism and pharmacokinetics, 2017, Volume: 32, Issue:6 Topics: Antimetabolites, Antineoplastic; Azacitidine; Camptothecin; Colonic Neoplasms; Cytarabine; Decitabine; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Etoposide; Gemcitabine; HCT116 Cells; Humans; Irinotecan; Phosphorylation	2017
A novel epigenetic modulating agent sensitizes pancreatic cells to a chemotherapy agent. PloS one, 2018, Volume: 13, Issue:6 Topics: Antineoplastic Agents; Azacitidine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; Epigenesis, Genetic; Humans; Irinotecan; Pancreas; Pancreatic Neoplasms; Topoisomerase I Inhibitors	2018
Molecular Docking Studies and Inhibition Properties of Some Antineoplastic Agents against Paraoxonase-I. Anti-cancer agents in medicinal chemistry, 2020, Volume: 20, Issue:7 Topics: Antineoplastic Agents; Aryldialkylphosphatase; Azacitidine; Dacarbazine; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Irinotecan; Molecular Docking Simulation; Molecular Structure	2020
Efficacy of sodium hypochlorite in the degradation antineoplastic drugs by NMR spectroscopy. Giornale italiano di medicina del lavoro ed ergonomia, 2020, Volume: 42, Issue:2 Topics: Antineoplastic Agents; Azacitidine; Carcinogens; Cytarabine; Decontamination; Drug Interactions; Ethanol; Fluorouracil; Humans; Hypochlorous Acid; Irinotecan; Magnetic Resonance Spectroscopy; Occupational Exposure; Preliminary Data; Sodium Chloride; Sodium Hypochlorite; Time Factors	2020