azacitidine and carboplatin

azacitidine has been researched along with carboplatin in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.76)18.2507
2000's6 (28.57)29.6817
2010's10 (47.62)24.3611
2020's4 (19.05)2.80

Authors

AuthorsStudies
Jakubowski, A; Kritz, AD; Maslak, P; Menendez-Botet, C; Raptis, G1
Brown, R; Kaye, SB; Plumb, JA; Sludden, J; Strathdee, G1
Aird, RE; Chen, H; Cummings, J; Jodrell, DI; Morris, RE; Muir, M; Ritchie, AA; Sadler, PJ1
Gottesman, MM; Liang, XJ; Pai-Panandiker, A; Shen, DW; Su, A1
Appleton, K; Barrett, S; Bellenger, K; Brown, R; Jadayel, D; Judson, I; Kaye, SB; Lee, C; Mackay, HJ; Mackay, L; McCormick, C; Plumb, JA; Reade, S; Schätzlein, A; Setanoians, A; Strathdee, G; Tang, A; Twelves, C1
Fu, S; Hu, W; Kavanagh, JJ; Li, Y; Shen, DY1
Karp, J1
Balch, C; Breen, T; Fang, F; Kulesavage, C; Li, L; Matei, DE; Nephew, KP; Schilder, J; Shen, C; Snyder, AJ; Zhang, S1
Bast, RC; Coleman, RL; Fu, S; Gershenson, DM; Hennessy, BT; Hu, W; Iyer, R; Kavanagh, JJ; Kurzrock, R; Levenback, CF; Markman, M; Sood, AK; Wolf, JK1
Arnold, A; Berry, WA; Fang, F; Huang, T; Matei, D; Nephew, KP; Schilder, J; Shen, C; Zeng, Y1
Bustinza-Linares, E; Falchook, GS; Fu, S; Hong, DS; Hu, W; Kurzrock, R; Moulder, S; Naing, A; Parkhurst, KL; Sood, AK; Wheler, JJ1
Appleton, K; Brown, R; Gabra, H; Glasspool, RM; Gore, ME; Halford, SE; Hall, GD; Kaye, S; Mackean, M; McNeish, IA; Paul, J; Pledge, S; Rustin, GJ; Ullah, R; Walker, J; Wilson, RH1
Fang, F; Li, M; Matei, D; Nephew, KP; Pilrose, J; Shen, C; Wang, Y; Wulfridge, P; Zuo, Q1
Cardenas, H; Condello, S; Fang, F; Liu, Y; Matei, D; Nephew, KP; Segar, M; Taverna, P; Wang, Y1
Benson, EA; Liu, Y; Matei, D; Nephew, KP; Skaar, TC1
Ando, T; Kimura, S; Kizuka, H; Kojima, K; Kubota, Y; Kusaba, K; Nishioka, A; Sano, H; Shindo, T; Ureshino, H1
Bowden, NA; Budden, T; van der Westhuizen, A1
Alvarez Secord, A; Armstrong, DK; Azab, M; Banerjee, S; Basu, B; Birrer, MJ; Blagden, SP; Braly, P; Fleming, GF; Ghamande, S; Hall, GD; Hao, Y; Hirte, HW; Jueliger, S; Keer, H; Kristeleit, R; Markham, MJ; Matei, D; Matulonis, UA; McGuire, WP; Naim, S; Nemunaitis, J; Nephew, KP; Oganesian, A; Oza, AM; Provencher, DM; Roman, LD; Schwartz, B1
Beller, M; Hein, JI; Junghanß, C; Murua Escobar, H; Nolte, I; Schille, JT; Weiner, F; Wu, XF1
Bowden, NA; van der Westhuizen, A; Wong-Brown, MW1
Althouse, S; Gentzler, R; Jalal, SI; Kalra, M; Mamdani, H; Perkins, S; Wei, CX1

Reviews

1 review(s) available for azacitidine and carboplatin

ArticleYear
5q- syndrome-like features as the first manifestation of myelodysplastic syndrome in a patient with an unbalanced whole-arm translocation der(5;19)(p10;q10).
    International journal of hematology, 2017, Volume: 105, Issue:5

    Topics: Anemia, Macrocytic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 19; Chromosomes, Human, Pair 5; Fatal Outcome; Female; Humans; Lenalidomide; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Thalidomide; Translocation, Genetic

2017

Trials

10 trial(s) available for azacitidine and carboplatin

ArticleYear
Pilot study of 5-azacytidine (5-AZA) and carboplatin (CBDCA) in patients with relapsed/refractory leukemia.
    American journal of hematology, 1996, Volume: 51, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Female; Humans; Leukemia; Male; Middle Aged; Pilot Projects; Recurrence

1996
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Oct-10, Volume: 25, Issue:29

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Azacitidine; Carboplatin; Cohort Studies; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Female; Humans; Male; Middle Aged; Neoplasms

2007
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
    Cancer, 2010, Sep-01, Volume: 116, Issue:17

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Decitabine; DNA Methylation; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Middle Aged; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Platinum Compounds

2010
Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer.
    Cancer, 2011, Apr-15, Volume: 117, Issue:8

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Carcinoma, Ovarian Epithelial; Disease-Free Survival; DNA Methylation; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Middle Aged; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms

2011
Epigenetic resensitization to platinum in ovarian cancer.
    Cancer research, 2012, May-01, Volume: 72, Issue:9

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Decitabine; Disease-Free Survival; DNA Methylation; Female; Humans; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Peritoneal Neoplasms

2012
Methylation and histone deacetylase inhibition in combination with platinum treatment in patients with advanced malignancies.
    Investigational new drugs, 2013, Volume: 31, Issue:5

    Topics: Acetylation; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; DNA Methylation; Female; Histone Deacetylase Inhibitors; Histones; Humans; Male; Middle Aged; Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Valproic Acid

2013
A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.
    British journal of cancer, 2014, Apr-15, Volume: 110, Issue:8

    Topics: Adaptor Proteins, Signal Transducing; Aged; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Female; Humans; Middle Aged; MutL Protein Homolog 1; Neoplasm Recurrence, Local; Nuclear Proteins; Ovarian Neoplasms; Platinum

2014
Carboplatin with Decitabine Therapy, in Recurrent Platinum Resistant Ovarian Cancer, Alters Circulating miRNAs Concentrations: A Pilot Study.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Biomarkers, Tumor; Carboplatin; Decitabine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; MicroRNAs; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Ovarian Neoplasms; Pilot Projects; Prognosis; Survival Rate; Young Adult

2015
A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2020, 03-01, Volume: 26, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Deoxycytidine; Doxorubicin; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gemcitabine; Humans; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Paclitaxel; Patient Safety; Polyethylene Glycols; Survival Rate; Topotecan; Treatment Outcome

2020
A Brief Report of a Phase II trial Evaluating Efficacy and Safety of Hypomethylating Agent Guadecitabine in Combination With Carboplatin in Extensive Stage Small Cell Lung Cancer.
    Clinical lung cancer, 2023, Volume: 24, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Humans; Lung Neoplasms; Small Cell Lung Carcinoma

2023

Other Studies

10 other study(ies) available for azacitidine and carboplatin

ArticleYear
Reversal of drug resistance in human tumor xenografts by 2'-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter.
    Cancer research, 2000, Nov-01, Volume: 60, Issue:21

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Base Pair Mismatch; Carboplatin; Carrier Proteins; Cisplatin; Colonic Neoplasms; Dacarbazine; Decitabine; DNA Methylation; DNA Repair; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Ovarian Neoplasms; Promoter Regions, Genetic; Temozolomide; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2000
In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer.
    British journal of cancer, 2002, May-20, Volume: 86, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Calcium Channel Blockers; Carboplatin; Cisplatin; Decitabine; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Edetic Acid; Female; Humans; Ligands; Mice; Mice, Nude; Neoplasm Proteins; Organometallic Compounds; Ovarian Neoplasms; Ruthenium Compounds; Structure-Activity Relationship; Verapamil; Xenograft Model Antitumor Assays

2002
Reduced expression of small GTPases and hypermethylation of the folate binding protein gene in cisplatin-resistant cells.
    British journal of cancer, 2004, Jul-19, Volume: 91, Issue:2

    Topics: Antineoplastic Agents; Azacitidine; Carboplatin; Carrier Proteins; Cell Survival; Cisplatin; Decitabine; DNA Methylation; Down-Regulation; Drug Resistance, Neoplasm; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Methotrexate; Monomeric GTP-Binding Proteins; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2004
Azacitidine enhances sensitivity of platinum-resistant ovarian cancer cells to carboplatin through induction of apoptosis.
    American journal of obstetrics and gynecology, 2009, Volume: 200, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carboplatin; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms

2009
Future research directions for the treatment of AML.
    Clinical advances in hematology & oncology : H&O, 2008, Volume: 6, Issue:11

    Topics: Antineoplastic Agents; Azacitidine; Biomedical Research; Carbazoles; Carboplatin; Cytarabine; Daunorubicin; Decitabine; Enzyme Inhibitors; Etoposide; Flavonoids; Furans; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Piperidines; Quinolones; Staurosporine; Topotecan; Tretinoin

2008
Decitabine reactivated pathways in platinum resistant ovarian cancer.
    Oncotarget, 2014, Jun-15, Volume: 5, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Cell Line, Tumor; Decitabine; DNA Methylation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression; Gene Expression Profiling; Humans; Ovarian Neoplasms

2014
Epigenetic targeting of ovarian cancer stem cells.
    Cancer research, 2014, Sep-01, Volume: 74, Issue:17

    Topics: Aldehyde Dehydrogenase; Animals; Azacitidine; Carboplatin; Cell Differentiation; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Ovarian Neoplasms

2014
Sequential decitabine and carboplatin treatment increases the DNA repair protein XPC, increases apoptosis and decreases proliferation in melanoma.
    BMC cancer, 2018, 01-26, Volume: 18, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Carboplatin; Cell Line, Tumor; Cell Proliferation; CpG Islands; Decitabine; DNA Damage; DNA Methylation; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Melanoma; Promoter Regions, Genetic

2018
Evaluation of combination protocols of the chemotherapeutic agent FX-9 with azacitidine, dichloroacetic acid, doxorubicin or carboplatin on prostate carcinoma cell lines.
    PloS one, 2021, Volume: 16, Issue:8

    Topics: Androgens; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Carboplatin; Cell Count; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Doxorubicin; Drug Synergism; Humans; Isoquinolines; Male; Prostatic Neoplasms

2021
Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy.
    BMC cancer, 2022, Jan-24, Volume: 22, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Carboplatin; Cell Growth Processes; Cell Line, Tumor; DNA Methylation; Female; Humans; Immune Checkpoint Inhibitors; Immunity; Neoplasm Grading; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Signal Transduction; Up-Regulation

2022