azacitidine and bortezomib

azacitidine has been researched along with bortezomib in 22 studies

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (13.64)29.6817
2010's15 (68.18)24.3611
2020's4 (18.18)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Giles, FJ1
Anderson, KC; Catley, L; Chauhan, D; Hideshima, T; Ikeda, H; Ishitsuka, K; Kiziltepe, T; Ocio, EM; Okawa, Y; Pozzi, S; Raje, N; Shiraishi, N; Vallet, S; Yasui, H1
Bechelli, J; Ifthikharuddin, JJ; Jordan, CT; Liesveld, JL; Lu, C; Messina, P; Mulford, D; Phillips Ii, GL; Rosell, KE1
Khong, T; Spencer, A1
de Lima, M; Koreth, J; Reddy, P1
Bloomfield, CD; Blum, W; Byrd, JC; Caligiuri, MA; Chan, KK; Curfman, JP; Devine, SM; Eisfeld, AK; Garr, C; Garzon, R; Geyer, S; Grever, MR; Jacob, S; Kefauver, C; Klisovic, R; Marcucci, G; Perrotti, D; Santhanam, R; Schwind, S; Tarighat, SS; Walker, A; Wang, H; Whitman, S1
Chung, HM; Clark, WB; Hazlett, AF; Kmieciak, M; Manjili, MH; McCarty, JM; Payne, KK; Roberts, CH; Sabo, RT; Sanford, K; Toor, AA; Williams, DC1
Brown, CO; Fitzgerald, MP; Goel, A; Salem, K; Schibler, J; Singh, N; Zhan, F1
Blum, W; Byrd, JC; Devine, SM; Garzon, R; Grever, MR; Humphries, K; Klisovic, RB; Marcucci, G; Schaaf, LJ; Walker, AR1
Du, H; Hu, X; Huang, J; Jiang, H; Xuan, H1
Jia, ZQ; Rong, HQ; Su, W; Tao, J; Wei, YL; Wei, YT; Yu, CX1
Dunleavy, K; Jiang, Z; Kuo, PY; Leshchenko, VV; Overbey, J; Parekh, S; Weniger, MA; Wiestner, A; Wilson, WH1
Adomako, A; Aguirre-Ghiso, JA; Biran, N; Calvo, V; Chari, A; Moore, K; Osman, K; Paton, AW; Paton, JC; Schewe, DM1
Cao, Y; Gu, WY; Lin, Y; Qiu, GQ; Wang, ZL; Wu, HQ; Wu, W; Xie, XB1
Bobin, A; Frouin, E; Hainaut, E; Masson Regnault, M; Plume, MA; Sibaud, V1
Chandran, NS; Koh, XQ; Ooi, XT; Sun, Y; Tan, CL1
Albayrak, M; Falay, M; Han, U; Maral, S; Ozturk, HBA; Sahin, O1

Reviews

3 review(s) available for azacitidine and bortezomib

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
New drugs in acute myeloid leukemia.
    Current oncology reports, 2002, Volume: 4, Issue:5

    Topics: Acute Disease; Adenine Nucleotides; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinonucleosides; Azacitidine; Bevacizumab; Boronic Acids; Bortezomib; Clofarabine; Cytosine; Decitabine; Dioxolanes; Humans; Indoles; Leukemia, Myeloid; Phthalazines; Pyrazines; Pyridines; Pyrroles; Thionucleotides

2002
Emerging therapies in hematopoietic stem cell transplantation.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012, Volume: 18, Issue:1 Suppl

    Topics: Antineoplastic Agents; Azacitidine; Boronic Acids; Bortezomib; Graft vs Host Disease; Graft vs Tumor Effect; Hematopoietic Stem Cell Transplantation; Humans; Hydroxamic Acids; Proteasome Inhibitors; Pyrazines; Vorinostat

2012

Trials

4 trial(s) available for azacitidine and bortezomib

ArticleYear
Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines.
    Cancer investigation, 2011, Volume: 29, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Azacitidine; Benzenesulfonates; Boronic Acids; Bortezomib; Cell Line, Tumor; Cell Proliferation; Cytarabine; Cytokines; Farnesyltranstransferase; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Niacinamide; Oxides; Phenylurea Compounds; Protease Inhibitors; Proteasome Inhibitors; Pyrazines; Pyridines; Sorafenib

2011
Clinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.
    Blood, 2012, Jun-21, Volume: 119, Issue:25

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Boronic Acids; Bortezomib; Cell Line, Tumor; Decitabine; Drug Evaluation, Preclinical; Female; Gene Expression Regulation, Leukemic; HEK293 Cells; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Pyrazines; Treatment Outcome; Validation Studies as Topic

2012
Epigenetic induction of adaptive immune response in multiple myeloma: sequential azacitidine and lenalidomide generate cancer testis antigen-specific cellular immunity.
    British journal of haematology, 2012, Volume: 158, Issue:6

    Topics: Adult; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Boronic Acids; Bortezomib; Dexamethasone; DNA Methylation; Doxorubicin; Drug Administration Schedule; Epigenesis, Genetic; Female; Humans; Immunity, Cellular; Lenalidomide; Lymphocyte Transfusion; Male; Middle Aged; Multiple Myeloma; Peripheral Blood Stem Cell Transplantation; Plasma Cells; Prospective Studies; Pyrazines; T-Cell Antigen Receptor Specificity; Thalidomide; Transplantation, Autologous

2012
Phase I study of azacitidine and bortezomib in adults with relapsed or refractory acute myeloid leukemia.
    Leukemia & lymphoma, 2014, Volume: 55, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Bone Marrow; Boronic Acids; Bortezomib; Female; Humans; Karyotype; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Recurrence, Local; Pyrazines; Treatment Outcome

2014

Other Studies

15 other study(ies) available for azacitidine and bortezomib

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Boronic Acids; Bortezomib; Cell Division; Cell Line, Tumor; Cell Survival; DNA Damage; DNA, Neoplasm; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Humans; Multiple Myeloma; Pyrazines

2007
Targeting HSP 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma.
    Molecular cancer therapeutics, 2011, Volume: 10, Issue:10

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azacitidine; Boronic Acids; Bortezomib; Cell Cycle; Cell Cycle Checkpoints; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; G1 Phase; HSP90 Heat-Shock Proteins; Humans; MAP Kinase Kinase Kinases; Multiple Myeloma; Pyrazines; Pyridones; Pyrimidines; Signal Transduction; STAT3 Transcription Factor

2011
Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma.
    Leukemia research, 2013, Volume: 37, Issue:8

    Topics: Antineoplastic Agents; Azacitidine; Boronic Acids; Bortezomib; Cell Line; Cell Line, Tumor; Decitabine; Dexamethasone; Disease Progression; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Heat-Shock Proteins; Humans; Hydrogen Peroxide; Hydroxamic Acids; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxidants; Prognosis; Pyrazines; Radiation, Ionizing; Reverse Transcriptase Polymerase Chain Reaction; Scavenger Receptors, Class A

2013
Down-regulation of CD9 by methylation decreased bortezomib sensitivity in multiple myeloma.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Azacitidine; Base Sequence; Boronic Acids; Bortezomib; Cell Line, Tumor; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Drug Resistance, Neoplasm; Humans; Multiple Myeloma; Pyrazines; Tetraspanin 29

2014
[Effects of bortezomib combined with 5-azacytidine on the apoptosis of K562 cells and expression of SHIP mRNA].
    Zhongguo shi yan xue ye xue za zhi, 2014, Volume: 22, Issue:5

    Topics: Apoptosis; Azacitidine; Boronic Acids; Bortezomib; Cell Proliferation; Humans; Inositol Polyphosphate 5-Phosphatases; K562 Cells; Phosphoric Monoester Hydrolases; Pyrazines; RNA, Messenger

2014
Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma.
    Oncotarget, 2015, Sep-29, Volume: 6, Issue:29

    Topics: Animals; Antineoplastic Agents; Azacitidine; Bortezomib; Cell Line, Tumor; Cell Survival; Decitabine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Humans; Lymphoma, Mantle-Cell; Mice; Mice, Nude; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Recurrence

2015
Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment.
    BMC cancer, 2015, May-30, Volume: 15

    Topics: Adult; Aged; Animals; Apoptosis; Azacitidine; Bortezomib; Cell Survival; Cyclin-Dependent Kinase 6; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins; Humans; Male; Mice; Middle Aged; Multiple Myeloma; Neoplasm Recurrence, Local; p21-Activated Kinases; Xenograft Model Antitumor Assays

2015
Decitabine enhances bortezomib treatment in RPMI 8226 multiple myeloma cells.
    Molecular medicine reports, 2016, Volume: 14, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Azacitidine; Bortezomib; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Proliferation; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Poly(ADP-ribose) Polymerases

2016
Spider-like injection site reaction after subcutaneous administration of haematological treatments.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:3

    Topics: Antineoplastic Agents; Azacitidine; Bortezomib; Humans; Injections, Subcutaneous; Male; Multiple Myeloma; Skin

2020
A retrospective analysis of dermatological problems in haematology and oncology patients at a tertiary Singapore hospital.
    The Australasian journal of dermatology, 2020, Volume: 61, Issue:4

    Topics: Antibodies, Bispecific; Antineoplastic Agents; Azacitidine; Bortezomib; ErbB Receptors; Hematologic Diseases; Humans; Immunotherapy; Neoplasms; Pemetrexed; Pyrimidines; Retrospective Studies; Singapore; Skin Diseases; Tertiary Care Centers

2020
Synchronous detection of multiple myeloma and acute myeloid leukemia: A diagnostic and therapeutic challenge.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2021, Volume: 27, Issue:2

    Topics: Aged; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Arm; Azacitidine; Biopsy; Bone Marrow; Bortezomib; Dexamethasone; Fatal Outcome; Granulocyte Precursor Cells; Humans; Leukemia, Myeloid, Acute; Male; Multiple Myeloma; Myeloma Proteins; Necrosis

2021