Compounds > azacitidine

azacitidine and ascorbic acid

azacitidine has been researched along with ascorbic acid in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's14 (70.00)24.3611
2020's4 (20.00)2.80

Authors

AuthorsStudies
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Ekins, S; Williams, AJ; Xu, JJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Flake, AW; Kitano, Y; Radu, A; Shaaban, A1
Bai, H; Chen, G; Mao, G; Song, T; Wang, Y1
Abboud, CN; Cashen, AF; DiPersio, JF; Gao, F; Hassan, A; Klco, JM; Procknow, E; Stockerl-Goldstein, KE; Uy, GL; Vij, R; Welch, JS; Westervelt, P1
Chen, J; Peng, S; Wang, H; Wei, Y1
Brown, KA; Cagnone, GL; Donoghue, J; Gough, DJ; Johns, TG; Johnson, J; Lee, W; St John, JC; Vaghjiani, V1
DeSimone, J; Ibanez, V; Lavelle, D; Mahmud, N; Rivers, A; Ruiz, MA; Vaitkus, K1
Baharvand, H; Dooley, S; Nussler, AK; Ruoss, M; Sajadian, SO; Samani, FS; Tripura, C1
Baylin, SB; Charlet, J; Grønbæk, K; Jones, PA; Liang, G; Liu, M; Ohtani, H; Shen, H; Zhang, YW; Zhou, W; Ørskov, AD1
Chandramohan, Y; Dhanaraj, P; Dhanasekaran, A; Khatri, N; Koka, P; Mundre, RS; Vig, S1
Damm, G; Ehret, L; Grom-Baumgarten, C; Ladurner, R; Naddalin, S; Nussler, A; Petkov, M; Ruoß, M; Sajadian, S; Seehofer, D; Vosough, M1
Dufva, IH; Gillberg, L; Grønbæk, K; Hajkova, P; Hansen, JW; Jones, PA; Liu, M; Lykkesfeldt, J; Madaj, Z; Mogensen, JB; Nasif, A; Ohtani, H; Rapin, N; Ørskov, AD1
Albulescu, A; Anton, G; Badiu, CV; Bostan, M; Botezatu, A; Dobrescu, R; Fudulu, A; Grancea, C; Huica, I; Iancu, IV; Manda, DA; Mihaila, M; Plesa, A; Vladoiu, SV1
Bensberg, M; Benson, M; Gustafsson, M; Lagerwall, C; Lentini, A; Nestor, CE; Rundquist, O; Selimović, A; Vogt, H1
Cao, H; Li, F; Lu, Y; Shi, K; Wang, H; Yu, D; Yu, M; Zhou, J1
Akbar, N; Anum, H; Haneef, K; Razzaq, SS; Salim, A; Usman, S1

Reviews

1 review(s) available for azacitidine and ascorbic acid

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for azacitidine and ascorbic acid

ArticleYear
Combination decitabine, arsenic trioxide, and ascorbic acid for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a phase I study.
    American journal of hematology, 2011, Volume: 86, Issue:9

    Topics: Adult; Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Azacitidine; Bone Marrow; Bone Marrow Cells; Cohort Studies; Decitabine; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Neovascularization, Pathologic; Oxides; Young Adult

2011
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
    Clinical epigenetics, 2019, 10-17, Volume: 11, Issue:1

    Topics: Administration, Oral; Aged; Aged, 80 and over; Ascorbic Acid; Azacitidine; CpG Islands; Denmark; DNA Methylation; Double-Blind Method; Epigenesis, Genetic; Female; Humans; Leukemia, Myeloid; Male; Middle Aged; Myelodysplastic Syndromes; Pilot Projects

2019

Other Studies

17 other study(ies) available for azacitidine and ascorbic acid

ArticleYear
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Selection, enrichment, and culture expansion of murine mesenchymal progenitor cells by retroviral transduction of cycling adherent bone marrow cells.
    Experimental hematology, 2000, Volume: 28, Issue:12

    Topics: Adipocytes; Alkaline Phosphatase; Animals; Ascorbic Acid; Azacitidine; beta-Galactosidase; Bone and Bones; Bone Marrow Cells; Cell Adhesion; Cell Differentiation; Cell Division; Cell Separation; Cells, Cultured; Dexamethasone; Drug Resistance; Glucocorticoids; Glycerophosphates; Mesoderm; Mice; Mice, Inbred BALB C; Neomycin; Osteogenesis; Retroviridae; Stem Cell Transplantation; Stem Cells; Transfection; Vascular Cell Adhesion Molecule-1

2000
Enhancement of cardiomyocyte differentiation from human embryonic stem cells.
    Science China. Life sciences, 2010, Volume: 53, Issue:5

    Topics: Adult; Ascorbic Acid; Azacitidine; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cell Line; Culture Media; Dimethyl Sulfoxide; Embryonic Stem Cells; Humans; Myocytes, Cardiac

2010
[Differentiation of porcine amniotic fluid stem cells into the beating cardiomyocytes].
    Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2011, Volume: 27, Issue:8

    Topics: Amniotic Fluid; Animals; Ascorbic Acid; Azacitidine; Cell Differentiation; Cells, Cultured; Embryoid Bodies; Embryonic Stem Cells; Female; Myocytes, Cardiac; Swine

2011
Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny.
    Cell death & disease, 2015, Feb-26, Volume: 6

    Topics: Ascorbic Acid; Azacitidine; Blotting, Western; Cell Differentiation; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA Copy Number Variations; DNA Methylation; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochondrial; Humans; Immunoprecipitation; Real-Time Polymerase Chain Reaction

2015
Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation.
    Epigenetics, 2015, Volume: 10, Issue:5

    Topics: 5-Methylcytosine; Animals; Animals, Newborn; Antineoplastic Agents; Ascorbic Acid; Azacitidine; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytosine; Decitabine; Dioxygenases; DNA Methylation; Erythroid Cells; gamma-Globins; Histone Demethylases; Humans; Hydroxyurea; Liver; Papio anubis; Promoter Regions, Genetic; Tranylcypromine

2015
Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
    Clinical epigenetics, 2016, Volume: 8

    Topics: Ascorbic Acid; Azacitidine; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Methylation; Drug Synergism; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms

2016
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
    Proceedings of the National Academy of Sciences of the United States of America, 2016, 09-13, Volume: 113, Issue:37

    Topics: Apoptosis; Ascorbic Acid; Ascorbic Acid Deficiency; Azacitidine; Cell Proliferation; Decitabine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Drug Synergism; Endogenous Retroviruses; Enzyme Inhibitors; Female; Hematologic Neoplasms; Humans; Interferons; Male; Methyltransferases; Proto-Oncogene Proteins; RNA, Double-Stranded

2016
Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin.
    PloS one, 2017, Volume: 12, Issue:11

    Topics: Animals; Ascorbic Acid; Azacitidine; beta Catenin; Cell Differentiation; Cell Proliferation; Down-Regulation; Drug Synergism; Heart; In Vitro Techniques; Male; Phosphorylation; Rats; Rats, Wistar; Wnt Signaling Pathway

2017
Epigenetic Modifications of the Liver Tumor Cell Line HepG2 Increase Their Drug Metabolic Capacity.
    International journal of molecular sciences, 2019, Jan-16, Volume: 20, Issue:2

    Topics: Ascorbic Acid; Azacitidine; Biomarkers, Tumor; Chromatin; Cytochrome P-450 Enzyme System; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Hepatocytes; Humans; Hydrocortisone; Insulin; Liver Neoplasms; Pharmaceutical Preparations; Snail Family Transcription Factors; Xenobiotics

2019
Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.
    Cancer biomarkers : section A of Disease markers, 2020, Volume: 28, Issue:2

    Topics: Adenocarcinoma, Follicular; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascorbic Acid; Azacitidine; Biomarkers, Tumor; Carcinogenesis; Cell Line, Tumor; Dioxygenases; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Epigenesis, Genetic; Feasibility Studies; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Mixed Function Oxygenases; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sensitivity and Specificity; Thyroid Cancer, Papillary; Thyroid Gland; Thyroid Neoplasms; Young Adult

2020
TET2 as a tumor suppressor and therapeutic target in T-cell acute lymphoblastic leukemia.
    Proceedings of the National Academy of Sciences of the United States of America, 2021, 08-24, Volume: 118, Issue:34

    Topics: Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Ascorbic Acid; Azacitidine; Biomarkers, Tumor; Cell Proliferation; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Humans; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; RNA-Seq; Tumor Cells, Cultured

2021
Knockdown of
    International journal of molecular sciences, 2022, Nov-09, Volume: 23, Issue:22

    Topics: Animals; Ascorbic Acid; Azacitidine; Chickens; Histones; Lysine; Muscle Development; Myoblasts

2022
Ascorbic acid and salvianolic acid B enhance the valproic acid and 5-azacytidinemediated cardiac differentiation of mesenchymal stem cells.
    Molecular biology reports, 2023, Volume: 50, Issue:9

    Topics: Ascorbic Acid; Azacitidine; Cardiovascular Diseases; Cell Differentiation; Cells, Cultured; Humans; Mesenchymal Stem Cells; Myocytes, Cardiac; Valproic Acid

2023