Compounds > atropine
Page last updated: 2024-09-05

atropine and zaprinast

atropine has been researched along with zaprinast in 4 studies

Compound Research Comparison

Studies
(atropine)		Trials
(atropine)		Recent Studies (post-2010)
(atropine)		Studies
(zaprinast)		Trials
(zaprinast)		Recent Studies (post-2010) (zaprinast)
26,7111,2591,697576287

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)zaprinast (IC50)
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.9442
cGMP-specific 3',5'-cyclic phosphodiesteraseCanis lupus familiaris (dog)0.76
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)2.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.55
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)2.6
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.55
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.55
cGMP-specific 3',5'-cyclic phosphodiesteraseBos taurus (cattle)0.4
G-protein coupled receptor 35Homo sapiens (human)0.8294

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Blaine, EH; McGraw, DE; McMahon, EG; Smits, GJ; Trapani, AJ1
Conanan, ND; Ellis, JL1
Ellis, JL; Fernandes, LB; Undem, BJ1
Alfonzo, MJ; González de Alfonzo, R; Guerra de González, L; Lippo de Bécemberg, I1

Other Studies

4 other study(ies) available for atropine and zaprinast

ArticleYear
Hemodynamic basis for the depressor activity of zaprinast, a selective cyclic GMP phosphodiesterase inhibitor.
    The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Atropine; Drug Interactions; Hemodynamics; Male; Propranolol; Purinones; Rats; Rats, Inbred Strains

1991
Modulation of relaxant responses evoked by a nitric oxide donor and by nonadrenergic, noncholinergic stimulation by isozyme-selective phosphodiesterase inhibitors in guinea pig trachea.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 272, Issue:3

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Atropine; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Electric Stimulation; Guanidines; Guinea Pigs; Indomethacin; Isoenzymes; Muscle Relaxation; Nitric Oxide; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Propranolol; Purinones; Pyridazines; Pyrrolidinones; Receptors, Adrenergic; Receptors, Cholinergic; Rolipram; Trachea; Vasoactive Intestinal Peptide; Xanthines

1995
Potentiation of nonadrenergic noncholinergic relaxation of human isolated bronchus by selective inhibitors of phosphodiesterase isozymes.
    American journal of respiratory and critical care medicine, 1994, Volume: 150, Issue:5 Pt 1

    Topics: Atropine; Bronchi; Colforsin; Electric Stimulation; Histamine; Humans; In Vitro Techniques; Indomethacin; Isoenzymes; Molsidomine; Muscle Relaxation; Nitroprusside; Phosphodiesterase Inhibitors; Propranolol; Purinones; Pyrrolidinones; Rolipram

1994
Cyclic nucleotide-dependent phosphodiesterases (PDEI) inhibition by muscarinic antagonists in bovine tracheal smooth muscle.
    Biochemical pharmacology, 2004, Aug-15, Volume: 68, Issue:4

    Topics: Animals; Atropine; Cattle; Cell-Free System; Cyclic AMP; Cyclic GMP; Muscarinic Antagonists; Muscle, Smooth; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Rolipram; Trachea; Vinca Alkaloids

2004